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Aliases for FPR3 Gene

Aliases for FPR3 Gene

  • Formyl Peptide Receptor 3 2 3
  • Formyl Peptide Receptor-Like 2 2 3 4
  • FPRL2 3 4 6
  • FMLP-Related Receptor II 3 4
  • FMLP-R-II 3 4
  • FPRH2 3 6
  • FPRH1 3 4
  • N-Formyl Peptide Receptor 3 3
  • FML2_HUMAN 3
  • RMLP-R-I 3
  • FMLPY 3

External Ids for FPR3 Gene

Previous HGNC Symbols for FPR3 Gene

  • FPRL2

Previous GeneCards Identifiers for FPR3 Gene

  • GC19P056992
  • GC19P052298
  • GC19P048629

Summaries for FPR3 Gene

GeneCards Summary for FPR3 Gene

FPR3 (Formyl Peptide Receptor 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include N-formyl peptide receptor activity. An important paralog of this gene is FPR2.

UniProtKB/Swiss-Prot for FPR3 Gene

  • Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system

Tocris Summary for FPR3 Gene

  • The formyl peptide receptor family, FPR1, FPR2 and FPR3 (formerly FPR, FPRL1 and FPRL2 respectively) are Gi protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes and found at lower expression levels on endothelial cells, neurons, astrocytes and hepatocytes. Formyl peptide receptors are involved in antibacterial host defence and inflammation. Activation of FPRs mediates induction of neutrophil chemotaxis, production of reactive oxygen species (ROS) to clear damaged cells and stimulation of degranulation of neutrophils. In addition, FPRs have a role in neutrophil transcriptional regulation and cytokine production, and induce neutrophil apoptosis in a ROS-dependent manner. Recently, FPRs have been implicated in the pathogenesis of amyloidosis, Alzheimer's disease, prion diseases and HIV. Ligand diversity is a prominent and unusual feature of FPR family receptors, suggesting that these receptors may have more complex functions than are currently appreciated. The human genes encoding FPR1, FPR2 and FPR3 are clustered on chromosome 19q13.3-13.4.

Gene Wiki entry for FPR3 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FPR3 Gene

Genomics for FPR3 Gene

Regulatory Elements for FPR3 Gene

Transcription factor binding sites by QIAGEN in the FPR3 gene promoter:

Genomic Location for FPR3 Gene

Start:
51,795,158 bp from pter
End:
51,826,189 bp from pter
Size:
31,032 bases
Orientation:
Plus strand

Genomic View for FPR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FPR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FPR3 Gene

Proteins for FPR3 Gene

  • Protein details for FPR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25089-FPR3_HUMAN
    Recommended name:
    N-formyl peptide receptor 3
    Protein Accession:
    P25089
    Secondary Accessions:

    Protein attributes for FPR3 Gene

    Size:
    353 amino acids
    Molecular mass:
    39965 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FPR3 Gene

Proteomics data for FPR3 Gene at MOPED

Post-translational modifications for FPR3 Gene

  • Glycosylation at Asn4 and Asn10
  • Modification sites at PhosphoSitePlus

Other Protein References for FPR3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FPR3 Gene

Domains for FPR3 Gene

Gene Families for FPR3 Gene

HGNC:
  • FPR :GPCR / Class A : Formyl peptide receptors
IUPHAR :

Suggested Antigen Peptide Sequences for FPR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25089

UniProtKB/Swiss-Prot:

FPR3_HUMAN :
  • P25089
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with FPR3: view

Function for FPR3 Gene

Molecular function for FPR3 Gene

UniProtKB/Swiss-Prot Function: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system

Gene Ontology (GO) - Molecular Function for FPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004982 N-formyl peptide receptor activity IEA --
genes like me logo Genes that share ontologies with FPR3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FPR3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FPR3 Gene

Localization for FPR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FPR3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FPR3 Gene COMPARTMENTS Subcellular localization image for FPR3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for FPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FPR3: view

Pathways for FPR3 Gene

genes like me logo Genes that share pathways with FPR3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat

Interacting Proteins for FPR3 Gene

Gene Ontology (GO) - Biological Process for FPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 8198572
GO:0006935 chemotaxis IEA --
GO:0007165 signal transduction TAS 8198572
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with FPR3: view

Compounds for FPR3 Gene

(5) Tocris Compounds for FPR3 Gene

Compound Action Cas Number
Ac9-25 Annexin I N-terminal peptide; acts as a FPR1 ligand [284040-76-2]
Boc-MLF FPR1 antagonist [67247-12-5]
WKYMVm FPR1, FPR2 and FPR3 receptor agonist [187986-17-0]
WKYMVM Selective FPR2 and FPR3 receptor agonist [187986-11-4]
WRW4 Selective FPR2 antagonist [878557-55-2]

(1) HMDB Compounds for FPR3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(8) IUPHAR Ligand for FPR3 Gene

Ligand Type Action Affinity Pubmed IDs
humanin Agonist Full agonist 8.95
F2L Agonist Full agonist 8.2
F2L-[125I]Tyr Agonist Full agonist 8
annexin I-(2-26) Agonist Full agonist 7
fMet-Met-Tyr-Ala-Leu-Phe Agonist Full agonist 6
WRWWWW Antagonist Antagonist 6
WKYMVm Agonist Full agonist 5.52
Hp(2-20) Agonist Full agonist 5

(2) Novoseek inferred chemical compound relationships for FPR3 Gene

Compound -log(P) Hits PubMed IDs
fmlp 73.1 4
calcium 24.6 3
genes like me logo Genes that share compounds with FPR3: view

Transcripts for FPR3 Gene

mRNA/cDNA for FPR3 Gene

Unigene Clusters for FPR3 Gene

Formyl peptide receptor 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FPR3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FPR3 Gene

No ASD Table

Relevant External Links for FPR3 Gene

GeneLoc Exon Structure for
FPR3
ECgene alternative splicing isoforms for
FPR3

Expression for FPR3 Gene

mRNA expression in normal human tissues for FPR3 Gene

mRNA differential expression in normal tissues according to GTEx for FPR3 Gene

This gene is overexpressed in Lung (4.7).

SOURCE GeneReport for Unigene cluster for FPR3 Gene Hs.445466

genes like me logo Genes that share expressions with FPR3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for FPR3 Gene

Orthologs for FPR3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FPR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FPR3 35
  • 99.62 (n)
  • 99.43 (a)
FPR3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fpr-rs3 36
  • 57 (a)
OneToMany
Fpr-rs4 36
  • 59 (a)
OneToMany
Fpr-rs6 36
  • 54 (a)
OneToMany
Fpr-rs7 36
  • 54 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 44 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii BX649278.1 36
  • 17 (a)
ManyToMany
Species with no ortholog for FPR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FPR3 Gene

ENSEMBL:
Gene Tree for FPR3 (if available)
TreeFam:
Gene Tree for FPR3 (if available)

Paralogs for FPR3 Gene

Selected SIMAP similar genes for FPR3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FPR3: view

Variants for FPR3 Gene

Sequence variations from dbSNP and Humsavar for FPR3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs763782 -- 51,821,841(-) GCCAT(C/G)ATTAC intron-variant
rs961551 -- 51,798,528(+) TTATA(C/T)GAGGG intron-variant
rs961552 -- 51,798,607(+) GGCTC(G/T)GTTCG intron-variant
rs961553 -- 51,798,654(+) CTAGG(C/T)ATGAT intron-variant
rs1057274 -- 51,824,760(+) ACACA(C/G)ACACC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for FPR3 Gene

Variant ID Type Subtype PubMed ID
esv638 CNV CNV 17122850
nsv524403 CNV Gain 19592680
nsv470151 CNV Gain 18288195
nsv458733 CNV Gain 19166990
dgv143e55 CNV Gain 17911159
dgv1112e1 CNV Complex 17122850
dgv425n27 CNV Gain 19166990

Relevant External Links for FPR3 Gene

HapMap Linkage Disequilibrium report
FPR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FPR3 Gene

Disorders for FPR3 Gene

(1) Novoseek inferred disease relationships for FPR3 Gene

Disease -log(P) Hits PubMed IDs
inflammation 15.2 1

Relevant External Links for FPR3

Genetic Association Database (GAD)
FPR3
Human Genome Epidemiology (HuGE) Navigator
FPR3
genes like me logo Genes that share disorders with FPR3: view

No data available for UniProtKB/Swiss-Prot for FPR3 Gene

Publications for FPR3 Gene

  1. Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. (PMID: 1612600) Bao L. … Gerard C. (Genomics 1992) 2 3 4
  2. Differential expression of members of the N-formylpeptide receptor gene cluster in human phagocytes. (PMID: 8198572) Durstin M. … Murphy P.M. (Biochem. Biophys. Res. Commun. 1994) 2 3 4
  3. Formyl peptide receptor-like 2 is expressed and functional in plasmacytoid dendritic cells, tissue-specific macrophage subpopulations, and eosinophils. (PMID: 19342677) Devosse T. … Parmentier M. (J. Immunol. 2009) 3 23
  4. The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. (PMID: 11285256) Christophe T. … Dahlgren C. (J. Biol. Chem. 2001) 3 23
  5. Human dendritic cells express functional formyl peptide receptor-like-2 (FPRL2) throughout maturation. (PMID: 12223529) Yang D. … Oppenheim J.J. (J. Leukoc. Biol. 2002) 3 23

Products for FPR3 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate FPR3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for FPR3
    • Block miRNA regulation of FPR3 using miScript Target Protectors

    Sources for FPR3 Gene

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