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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FPR3 Gene

protein-coding   GIFtS: 59
GCID: GC19P052298

Formyl Peptide Receptor 3

(Previous name: formyl peptide receptor-like 2)
(Previous symbol: FPRL2)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Formyl Peptide Receptor 31 2     FPRH22 5
FPRL21 2 3 5     FML2_HUMAN2
Formyl Peptide Receptor-Like 21 2 3     FMLPY2
FMLP-R-II2 3     RMLP-R-I2
FPRH12 3     N-Formyl Peptide Receptor 32
FMLP-Related Receptor II2 3     

External Ids:    HGNC: 38281   Entrez Gene: 23592   Ensembl: ENSG000001874747   OMIM: 1365395   UniProtKB: P250893   

Export aliases for FPR3 gene to outside databases

Previous GC identifers: GC19P056992 GC19P048629


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FPR3 Gene: 
FPR3 (formyl peptide receptor 3) is a protein-coding gene. Diseases associated with FPR3 include prion disease, and amyloidosis, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Peptide GPCRs. GO annotations related to this gene include N-formyl peptide receptor activity. An important paralog of this gene is LTB4R.

UniProtKB/Swiss-Prot: FPR3_HUMAN, P25089
Function: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic
factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a
G-protein that activates a phosphatidylinositol-calcium second messenger system

summary for FPR3 Gene:
The formyl peptide receptor family, FPR1, FPR2 and FPR3 (formerly FPR, FPRL1 and FPRL2 respectively) are Gi
protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes and found at lower
expression levels on endothelial cells, neurons, astrocytes and hepatocytes. Formyl peptide receptors are
involved in antibacterial host defence and inflammation. Activation of FPRs mediates induction of neutrophil
chemotaxis, production of reactive oxygen species (ROS) to clear damaged cells and stimulation of
degranulation of neutrophils. In addition, FPRs have a role in neutrophil transcriptional regulation and
cytokine production, and induce neutrophil apoptosis in a ROS-dependent manner. Recently, FPRs have been
implicated in the pathogenesis of amyloidosis, Alzheimer's disease, prion diseases and HIV. Ligand diversity
is a prominent and unusual feature of FPR family receptors, suggesting that these receptors may have more
complex functions than are currently appreciated. The human genes encoding FPR1, FPR2 and FPR3 are clustered
on chromosome 19q13.3-13.4.

Gene Wiki entry for FPR3 (Formyl peptide receptor 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FPR3 gene promoter:
         ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFPR3 promoter sequence
   Search SABiosciences Chromatin IP Primers for FPR3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FPR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3-q13.4   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.3-q13.4

FPR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FPR3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P052298:  view genomic region     (about GC identifiers)

Start:
52,298,411 bp from pter      End:
52,329,442 bp from pter
Size:
31,032 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FPR3_HUMAN, P25089 (See protein sequence)
Recommended Name: N-formyl peptide receptor 3  
Size: 353 amino acids; 39965 Da
Subcellular location: Cell membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for FPR3: NX_P25089

Explore proteomics data for FPR3 at MOPED 

FPR3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

FPR3 Protein Expression

REFSEQ proteins: NP_002021.3  
ENSEMBL proteins: 
 ENSP00000341821   ENSP00000470471  
Reactome Protein details: P25089
Human Recombinant Protein Products for FPR3: 
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Cloud-Clone Corp. Proteins for FPR3 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral to membrane IEA--

FPR3 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
FPR: GPCR / Class A : Formyl peptide receptors

IUPHAR Guide to PHARMACOLOGY protein family classification: FPR3 
Formylpeptide receptors

4 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000826 Formyl_pep_rcpt
 IPR027347 Formyl_pep_3_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P25089

ProtoNet protein and cluster: P25089

1 Blocks protein domain: IPB000826 Formyl-methionyl peptide receptor signature

UniProtKB/Swiss-Prot: FPR3_HUMAN, P25089
Similarity: Belongs to the G-protein coupled receptor 1 family


FPR3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: FPR3_HUMAN, P25089
Function: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic
factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a
G-protein that activates a phosphatidylinositol-calcium second messenger system

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity ----
GO:0004982N-formyl peptide receptor activity IEA--
     
FPR3 for ontologies           About GeneDecksing


Animal Models:
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FPR3 
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miRNA
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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for FPR3 About                                                                                                See pathways by source

SuperPathContained pathways About
1Class A/1 (Rhodopsin-like receptors)
Class A/1 (Rhodopsin-like receptors)0.71
G alpha (i) signalling events0.46
GPCR ligand binding0.71
GPCRs, Class A Rhodopsin-like0.41
Peptide ligand-binding receptors0.60
Neuroactive ligand-receptor interaction0.37
2Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46
Peptide GPCRs0.46
3Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
4Staphylococcus aureus infection
Staphylococcus aureus infection
5Formyl peptide receptors bind formyl peptides and many other ligands
Formyl peptide receptors bind formyl peptides and many other ligands

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for FPR3
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q


2 BioSystems Pathways for FPR3
    GPCRs, Class A Rhodopsin-like
Peptide GPCRs


5/8        Reactome Pathways for FPR3 (see all 8)
    GPCR downstream signaling
Peptide ligand-binding receptors
Formyl peptide receptors bind formyl peptides and many other ligands
Signal Transduction
Signaling by GPCR


2         Kegg Pathways  (Kegg details for FPR3):
    Neuroactive ligand-receptor interaction
Staphylococcus aureus infection


FPR3 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FPR3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/144 Interacting proteins for FPR3 (ENSP000003418214) via UniProtKB, MINT, STRING, and/or I2D (see all 144)
InteractantInteraction Details
GeneCardExternal ID(s)
ACKR3ENSP000002729284STRING: ENSP00000272928
ADCY4ENSP000003121264STRING: ENSP00000312126
ADCY9ENSP000002940164STRING: ENSP00000294016
ADORA3ENSP000003587304STRING: ENSP00000358730
ADRA2AENSP000002801554STRING: ENSP00000280155
About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006928cellular component movement TAS8198572
GO:0006935chemotaxis IEA--
GO:0007165signal transduction TAS8198572
GO:0007186G-protein coupled receptor signaling pathway ----
GO:0016477cell migration ----

FPR3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FPR3 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Compounds for FPR3 available from Tocris Bioscience    About this table
CompoundAction CAS #
Boc-MLFFPR1 antagonist[67247-12-5]
WRW4Selective FPR2 antagonist[878557-55-2]
MMK 1Potent and selective FPR2 agonist[271246-66-3]
WKYMVm FPR1, FPR2 and FPR3 receptor agonist [187986-17-0]
WKYMVMSelective FPR2 and FPR3 receptor agonist[187986-11-4]

1 HMDB Compound for FPR3    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--

8 IUPHAR Ligands for FPR3 (FPR3)    About this table 
LigandTypeActionAffinityPubmed IDs
humanin
AgonistFull agonist8.9515465011
F2L
AgonistFull agonist8 - 8.215623572
F2L-[125I]Tyr
AgonistFull agonist815623572
annexin I-(2-26)
AgonistFull agonist5 - 715187149
fMet-Met-Tyr-Ala-Leu-Phe
AgonistFull agonist616025565
WRWWWW
AntagonistAntagonist616476585
WKYMVm
AgonistFull agonist5.5211285256
Hp(2-20)
AgonistFull agonist511602630

2 Novoseek inferred chemical compound relationships for FPR3 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
fmlp 73.1 4 15187157 (2), 15494526 (1), 16002663 (1)
calcium 24.6 4 16476585 (2), 11285256 (1)

Search CenterWatch for drugs/clinical trials and news about FPR3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FPR3 gene: 
NM_002030.3  

Unigene Cluster for FPR3:

Formyl peptide receptor 3
Hs.445466  [show with all ESTs]
Unigene Representative Sequence: BC059388
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000339223(uc002pxt.1) ENST00000595991

miRNA
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Inhib. RNA
Products:
     
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FPR3
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                     Customized lentivirus expression plasmids for stable overexpression of FPR3 
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FPR3
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FPR3

Additional mRNA sequence: 

AK123030.1 AK292541.1 BC059388.1 BC069070.1 BC069593.1 BC069812.1 M76673.1 

4 DOTS entries:

DT.75163332  DT.443456  DT.121504034  DT.100746088 

24/47 AceView cDNA sequences (see all 47):

BC069593 BF939676 AW192406 N90486 CR618932 NM_002030 BF438514 BC069812 
BC069070 AW450974 CB996360 AA909857 BF939956 BX391732 BX327845 BP344044 
BX482983 AI423536 AW468743 BC059388 BF432699 BP346341 AI569257 AW026543 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FPR3 expression in normal human tissues (normalized intensities)      FPR3 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AATGAATGTT
FPR3 Expression
About this image


FPR3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/3 selected tissues (see all 3) fully expand
 
 Endothelium (Cardiovascular System)
         Peripheral blood-derived early endothelial progenitor cells
 
 Blood (Hematopoietic System)
         Peripheral Blood Immature Myeloid Dendritic Cells   
 
 Uncategorized (Uncategorized)
         PureStem progenitor RP1-MV2-8

See FPR3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FPR3

SOURCE GeneReport for Unigene cluster: Hs.445466
    SABiosciences Expression via Pathway-Focused PCR Array including FPR3: 
          G Protein Coupled Receptors 384HT in human mouse rat

Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FPR3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FPR3 gene from 2/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
31(a)
possible ortholog
LGf(1022326-1023366)
zebrafish
(Danio rerio)
Actinopterygii CABZ01029333.16
CABZ01029334.16
(see all 5)
Uncharacterized protein
(see all 5)
32(a)
30(a)
(see all 5)
possible ortholog
possible ortholog
(see all 5)
19(11141054-11142081)
19(11148973-11150089)
        Species with no ortholog for FPR3

ENSEMBL Gene Tree for FPR3 (if available)
TreeFam Gene Tree for FPR3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for FPR3 gene
LTB4R2  LTB4R22  GPR332  FPR12  C5AR12  GPR322  GPR1522  FPR22  
C5AR22  C3AR12  PTGDR22  GPR12  CMKLR12  
17 SIMAP similar genes for FPR3 using alignment to 1 protein entry:     FPR3_HUMAN:
FPRL2    FPR2    FPR1    GPR32    gpcr    CMKLR1
CXCR7    GPR33    GPR1    PTGDR2    CXCR1    C5AR1
CXCR2    IL8RB    CXCR4    AGTR1    CCR4

FPR3 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/683 SNPs in FPR3 are shown (see all 683)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1474194831,2
Cuntested152327020(+) TCTCCA/C/GTTCCT 2 I L mis11NA 4550
rs178347991,2
C,F,H--52296537(+) CCAAAA/CCTTTT 1 -- us2k110Minor allele frequency- C:0.19NA NS WA EA 612
rs1919024781,2
--52296651(+) CTTGTC/TTTGTG 1 -- us2k10--------
rs1428843601,2
--52296658(+) TGTGGC/TTCTCC 1 -- us2k10--------
rs787732071,2
C,F--52296778(+) TAGGGG/TCAGAA 1 -- us2k12Minor allele frequency- T:0.08NA EA 240
rs1164158251,2
F--52296802(+) ATCTCG/AGCAAT 1 -- us2k11Minor allele frequency- A:0.02WA 118
rs129787481,2
C,F--52296815(+) TGTGGA/TGTGTA 1 -- us2k14Minor allele frequency- T:0.04NA 126
rs19782421,2
C,F,O,H--52296853(+) TCTCTC/ACATGC 1 -- us2k129Minor allele frequency- A:0.26NS EA NA WA CSA 2571
rs1465755361,2
--52296880(+) TCTTTA/GTAACT 1 -- us2k10--------
rs1840690741,2
--52296926(+) TGTCAC/TAGATT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for FPR3 (52298411 - 52329442 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for FPR3:    About this table     
Variant IDTypeSubtypePubMed ID
nsv458733CNV Gain19166990
nsv524403CNV Gain19592680
dgv143e55CNV Gain17911159
dgv425n27CNV Gain19166990
nsv470151CNV Gain18288195
esv638CNV CNV17122850
dgv1112e1CNV Complex17122850

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing FPR3
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 136539    OMIM disorders: --

7 diseases for FPR3:    About MalaCards
prion disease    amyloidosis    alzheimer's disease    endotheliitis
hepatitis b    neuronitis    hepatitis


FPR3 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

1 Novoseek inferred disease relationship for FPR3 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation 15.2 1 19707939 (1)

Genetic Association Database (GAD): FPR3
Human Genome Epidemiology (HuGE) Navigator: FPR3 (1 document)

Export disorders for FPR3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FPR3 gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with FPR3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Differential expression of members of the N-formylpeptide receptor gene cluster in human phagocytes. (PubMed id 8198572)1, 2, 3 Durstin M....Murphy P.M. (1994)
  2. Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. (PubMed id 1612600)1, 2, 3 Bao L.... Gerard C. (1992)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Human dendritic cells express functional formyl peptide receptor-like-2 (FPRL2) throughout maturation. (PubMed id 12223529)1, 9 Yang D....Oppenheim J.J. (2002)
  5. Formyl peptide receptor-like 2 is expressed and functional in plasmacytoid dendritic cells, tissue-specific macrophage subpopulations, and eosinophils. (PubMed id 19342677)1, 9 Devosse T....Parmentier M. (2009)
  6. The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. (PubMed id 11285256)1, 9 Christophe T....Dahlgren C. (2001)
  7. The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met inhibits human monocyte-derived dendritic cell maturation via formyl peptide receptor and formyl peptide receptor-like 2. (PubMed id 16002663)1, 9 Kang H.K....Bae Y.S. (2005)
  8. Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4. (PubMed id 12410796)1, 9 Christophe T....Dahlgren C. (2002)
  9. Processing of HEBP1 by cathepsin D gives rise to F2L, the agonist of formyl peptide receptor 3. (PubMed id 21709160)1 Devosse T....Parmentier M. (2011)
  10. The cross-talk between the urokinase receptor and fML P receptors regulates the activity of the CXCR4 chemokine receptor. (PubMed id 20972812)1 Montuori N....Ragno P. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2359 HGNC: 3828 AceView: FPRL2 Ensembl:ENSG00000187474 euGenes: HUgn2359
ECgene: FPR3 Kegg: 2359 H-InvDB: FPR3

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FPR3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for FPR3 gene:
Search GeneIP for patents involving FPR3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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