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FPR3 Gene

protein-coding   GIFtS: 59
GCID: GC19P052298

Formyl Peptide Receptor 3

(Previous name: formyl peptide receptor-like 2)
(Previous symbol: FPRL2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Formyl Peptide Receptor 31 2     FPRH22 5
FPRL21 2 3 5     FML2_HUMAN2
Formyl Peptide Receptor-Like 21 2 3     FMLPY2
FMLP-R-II2 3     RMLP-R-I2
FPRH12 3     N-Formyl Peptide Receptor 32
FMLP-Related Receptor II2 3     

External Ids:    HGNC: 38281   Entrez Gene: 23592   Ensembl: ENSG000001874747   OMIM: 1365395   UniProtKB: P250893   

Export aliases for FPR3 gene to outside databases

Previous GC identifers: GC19P056992 GC19P048629


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FPR3 Gene:
FPR3 (formyl peptide receptor 3) is a protein-coding gene. GO annotations related to this gene include N-formyl peptide receptor activity. An important paralog of this gene is LTB4R.

UniProtKB/Swiss-Prot: FPR3_HUMAN, P25089
Function: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic
factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a
G-protein that activates a phosphatidylinositol-calcium second messenger system

summary for FPR3 Gene:
The formyl peptide receptor family, FPR1, FPR2 and FPR3 (formerly FPR, FPRL1 and FPRL2 respectively) are Gi
protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes and found at lower
expression levels on endothelial cells, neurons, astrocytes and hepatocytes. Formyl peptide receptors are
involved in antibacterial host defence and inflammation. Activation of FPRs mediates induction of neutrophil
chemotaxis, production of reactive oxygen species (ROS) to clear damaged cells and stimulation of
degranulation of neutrophils. In addition, FPRs have a role in neutrophil transcriptional regulation and
cytokine production, and induce neutrophil apoptosis in a ROS-dependent manner. Recently, FPRs have been
implicated in the pathogenesis of amyloidosis, Alzheimer's disease, prion diseases and HIV. Ligand diversity
is a prominent and unusual feature of FPR family receptors, suggesting that these receptors may have more
complex functions than are currently appreciated. The human genes encoding FPR1, FPR2 and FPR3 are clustered
on chromosome 19q13.3-13.4.

Gene Wiki entry for FPR3 (Formyl peptide receptor 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the FPR3 gene promoter:
         ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFPR3 promoter sequence
   Search Chromatin IP Primers for FPR3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FPR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3-q13.4   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.3-q13.4

FPR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FPR3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P052298:  view genomic region     (about GC identifiers)

Start:
52,298,411 bp from pter      End:
52,329,442 bp from pter
Size:
31,032 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FPR3_HUMAN, P25089 (See protein sequence)
Recommended Name: N-formyl peptide receptor 3  
Size: 353 amino acids; 39965 Da

Explore the universe of human proteins at neXtProt for FPR3: NX_P25089

Explore proteomics data for FPR3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn4, Asn10

  • See FPR3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002021.3  
    ENSEMBL proteins: 
     ENSP00000341821   ENSP00000470471  
    Reactome Protein details: P25089

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FPR: GPCR / Class A : Formyl peptide receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: FPR3
    Formylpeptide receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000826 Formyl_pep_rcpt
     IPR027347 Formyl_pep_3_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P25089

    ProtoNet protein and cluster: P25089

    1 Blocks protein domain: IPB000826 Formyl-methionyl peptide receptor signature

    UniProtKB/Swiss-Prot: FPR3_HUMAN, P25089
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with FPR3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FPR3_HUMAN, P25089
    Function: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic
    factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a
    G-protein that activates a phosphatidylinositol-calcium second messenger system

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004982N-formyl peptide receptor activity IEA--
         
    Find genes that share ontologies with FPR3           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FPR3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FPR3_HUMAN, P25089: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with FPR3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FPR3 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    Peptide ligand-binding receptors0.60
    Formyl peptide receptors bind formyl peptides and many other ligands0.00
    G alpha (i) signalling events0.44
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Staphylococcus aureus infection
    Staphylococcus aureus infection


    Find genes that share SuperPaths with FPR3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FPR3
        Transendothelial Migration of Leukocytes
    fMLP Pathway

    2 BioSystems Pathways for FPR3
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs


    2 Reactome Pathways for FPR3
        Formyl peptide receptors bind formyl peptides and many other ligands
    G alpha (i) signalling events


    2 Kegg Pathways  (Kegg details for FPR3):
        Neuroactive ligand-receptor interaction
    Staphylococcus aureus infection

        Pathway & Disease-focused RT2 Profiler PCR Array including FPR3: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FPR3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FPR3 (ENSP000003418214) via UniProtKB, MINT, STRING, and/or I2D (see all 144)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACKR3ENSP000002729284STRING: ENSP00000272928
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADCY9ENSP000002940164STRING: ENSP00000294016
    ADORA3ENSP000003587304STRING: ENSP00000358730
    ADRA2AENSP000002801554STRING: ENSP00000280155
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS8198572
    GO:0006935chemotaxis IEA--
    GO:0007165signal transduction TAS8198572
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with FPR3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for FPR3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Boc-MLFFPR1 antagonist[67247-12-5]
    WRW4Selective FPR2 antagonist[878557-55-2]
    MMK 1Potent and selective FPR2 agonist[271246-66-3]
    WKYMVm FPR1, FPR2 and FPR3 receptor agonist [187986-17-0]
    WKYMVMSelective FPR2 and FPR3 receptor agonist[187986-11-4]

    1 HMDB Compound for FPR3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    8 IUPHAR Ligands for FPR3 (FPR3)    About this table
    LigandTypeActionAffinityPubmed IDs
    humanin
    AgonistFull agonist8.9515465011
    F2L
    AgonistFull agonist8 - 8.215623572
    F2L-[125I]Tyr
    AgonistFull agonist815623572
    annexin I-(2-26)
    AgonistFull agonist5 - 715187149
    fMet-Met-Tyr-Ala-Leu-Phe
    AgonistFull agonist616025565
    WRWWWW
    AntagonistAntagonist616476585
    WKYMVm
    AgonistFull agonist5.5211285256
    Hp(2-20)
    AgonistFull agonist511602630

    2 Novoseek inferred chemical compound relationships for FPR3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fmlp 73.1 4 15187157 (2), 15494526 (1), 16002663 (1)
    calcium 24.6 4 16476585 (2), 11285256 (1)



    Find genes that share compounds with FPR3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FPR3 gene: 
    NM_002030.3  

    Unigene Cluster for FPR3:

    Formyl peptide receptor 3
    Hs.445466  [show with all ESTs]
    Unigene Representative Sequence: BC059388
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000339223(uc002pxt.1) ENST00000595991
    miRNA
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    Additional mRNA sequence: 

    AK123030.1 AK292541.1 BC059388.1 BC069070.1 BC069593.1 BC069812.1 M76673.1 

    4 DOTS entries:

    DT.75163332  DT.443456  DT.121504034  DT.100746088 

    Selected AceView cDNA sequences (see all 47):

    BC069812 BF438514 NM_002030 AW192406 N90486 AW450974 BF939676 CR618932 
    BC069070 BC069593 AW027912 AW026543 BX482983 BF432699 AI423536 BF939956 
    W44888 AA909857 AI569257 BP346341 BX391732 CB996360 M76673 CB991000 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FPR3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGAATGTT
    FPR3 Expression
    About this image

    FPR3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FPR3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445466
        Pathway & Disease-focused RT2 Profiler PCR Array including FPR3: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FPR3 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    32(a)
    1 → many
    GL343604.1(277-1212)
    zebrafish
    (Danio rerio)
    Actinopterygii BX649278.16
    Uncharacterized protein
    17(a)
    many ↔ many
    7(5955792-5966587) ENSDARG00000091626
            Species with no ortholog for FPR3

    ENSEMBL Gene Tree for FPR3 (if available)
    TreeFam Gene Tree for FPR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FPR3 gene
    LTB4R2  GPR332  LTB4R22  FPR12  C5AR12  GPR322  GPR1522  FPR22  
    C5AR22  C3AR12  PTGDR22  GPR12  ENSG000002726582  CMKLR12  
    17 SIMAP similar genes for FPR3 using alignment to 1 protein entry:     FPR3_HUMAN:
    FPRL2    FPR2    FPR1    GPR32    gpcr    CMKLR1
    ACKR3    GPR33    GPR1    PTGDR2    CXCR1    C5AR1
    CXCR2    IL8RB    CXCR4    AGTR1    CCR4

    Find genes that share paralogs with FPR3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FPR3 (see all 683)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1474194831,2
    Cuntested152327020(+) TCTCCA/C/GTTCCT 2 I L mis11NA 4550
    rs178347991,2
    C,F,H--52296537(+) CCAAAA/CCTTTT 1 -- us2k110Minor allele frequency- C:0.19NA NS WA EA 612
    rs1919024781,2
    --52296651(+) CTTGTC/TTTGTG 1 -- us2k10--------
    rs1428843601,2
    --52296658(+) TGTGGC/TTCTCC 1 -- us2k10--------
    rs787732071,2
    C,F--52296778(+) TAGGGG/TCAGAA 1 -- us2k12Minor allele frequency- T:0.08NA EA 240
    rs1164158251,2
    F--52296802(+) ATCTCG/AGCAAT 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs129787481,2
    C,F--52296815(+) TGTGGA/TGTGTA 1 -- us2k14Minor allele frequency- T:0.04NA 126
    rs19782421,2
    C,F,O,H--52296853(+) TCTCTC/ACATGC 1 -- us2k129Minor allele frequency- A:0.26NS EA NA WA CSA 2571
    rs1465755361,2
    --52296880(+) TCTTTA/GTAACT 1 -- us2k10--------
    rs1840690741,2
    --52296926(+) TGTCAC/TAGATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FPR3 (52298411 - 52329442 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for FPR3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv458733CNV Gain19166990
    nsv524403CNV Gain19592680
    dgv143e55CNV Gain17911159
    dgv425n27CNV Gain19166990
    nsv470151CNV Gain18288195
    esv638CNV CNV17122850
    dgv1112e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 136539    OMIM disorders: --


    Find genes that share disorders with FPR3           About GenesLikeMe

    1 Novoseek inferred disease relationship for FPR3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 15.2 1 19707939 (1)

    Genetic Association Database (GAD): FPR3
    Human Genome Epidemiology (HuGE) Navigator: FPR3 (1 document)

    Export disorders for FPR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FPR3 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with FPR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential expression of members of the N-formylpeptide receptor gene cluster in human phagocytes. (PubMed id 8198572)1, 2, 3 Durstin M.... Murphy P.M. (Biochem. Biophys. Res. Commun. 1994)
    2. Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. (PubMed id 1612600)1, 2, 3 Bao L.... Gerard C. (Genomics 1992)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Human dendritic cells express functional formyl peptide receptor-like-2 (FPRL2) throughout maturation. (PubMed id 12223529)1, 9 Yang D....Oppenheim J.J. (J. Leukoc. Biol. 2002)
    5. Formyl peptide receptor-like 2 is expressed and functional in plasmacytoid dendritic cells, tissue-specific macrophage subpopulations, and eosinophils. (PubMed id 19342677)1, 9 Devosse T....Parmentier M. (J. Immunol. 2009)
    6. The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. (PubMed id 11285256)1, 9 Christophe T....Dahlgren C. (J. Biol. Chem. 2001)
    7. The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met inhibits human monocyte-derived dendritic cell maturation via formyl peptide receptor and formyl peptide receptor-like 2. (PubMed id 16002663)1, 9 Kang H.K....Bae Y.S. (J. Immunol. 2005)
    8. Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4. (PubMed id 12410796)1, 9 Christophe T....Dahlgren C. (Scand. J. Immunol. 2002)
    9. Helicobacter pylori HP(2-20) induces eosinophil activation and accumulation in superficial gastric mucosa and stimulates VEGF-alpha and TGF-beta release by interacting with formyl-peptide receptors. (PubMed id 24067461)1 Prevete N....De Paulis A. (Int J Immunopathol Pharmacol 2013)
    10. Processing of HEBP1 by cathepsin D gives rise to F2L, the agonist of formyl peptide receptor 3. (PubMed id 21709160)1 Devosse T....Parmentier M. (J. Immunol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2359 HGNC: 3828 AceView: FPRL2 Ensembl:ENSG00000187474 euGenes: HUgn2359
    ECgene: FPR3 Kegg: 2359 H-InvDB: FPR3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FPR3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FPR3 gene:
    Search GeneIP for patents involving FPR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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