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FPR2 Gene

protein-coding   GIFtS: 63
GCID: GC19P052264

Formyl Peptide Receptor 2

(Previous name: formyl peptide receptor-like 1)
(Previous symbol: FPRL1)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Formyl Peptide Receptor 21 2     LXA4 Receptor2 3
FPRL11 2 3 5     ALXR2
Formyl Peptide Receptor-Like 11 2 3     FMLP-R-II2
FPRH12 3 5     FMLPX2
HM632 3 5     FPR2A2
LXA4R2 3 5     FPRH22
FMLP-R-I2 3     Lipoxin A4 Receptor (Formyl Peptide Receptor Related)2
RFP2 3     N-Formyl Peptide Receptor 22
FMLP-Related Receptor I2 3     Lipoxin A4 Receptor3

External Ids:    HGNC: 38271   Entrez Gene: 23582   Ensembl: ENSG000001710497   OMIM: 1365385   UniProtKB: P250903   

Export aliases for FPR2 gene to outside databases

Previous GC identifers: GC19P056955 GC19P048595


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FPR2 Gene:
FPR2 (formyl peptide receptor 2) is a protein-coding gene. Diseases associated with FPR2 include prion disease, and bacterial meningitis. GO annotations related to this gene include N-formyl peptide receptor activity and G-protein coupled receptor activity. An important paralog of this gene is LTB4R.

UniProtKB/Swiss-Prot: FPR2_HUMAN, P25090
Function: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic
factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a
G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could
result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4
(leukotriene B4)

summary for FPR2 Gene:
The formyl peptide receptor family, FPR1, FPR2 and FPR3 (formerly FPR, FPRL1 and FPRL2 respectively) are Gi
protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes and found at lower
expression levels on endothelial cells, neurons, astrocytes and hepatocytes. Formyl peptide receptors are
involved in antibacterial host defence and inflammation. Activation of FPRs mediates induction of neutrophil
chemotaxis, production of reactive oxygen species (ROS) to clear damaged cells and stimulation of
degranulation of neutrophils. In addition, FPRs have a role in neutrophil transcriptional regulation and
cytokine production, and induce neutrophil apoptosis in a ROS-dependent manner. Recently, FPRs have been
implicated in the pathogenesis of amyloidosis, Alzheimer's disease, prion diseases and HIV. Ligand diversity
is a prominent and unusual feature of FPR family receptors, suggesting that these receptors may have more
complex functions than are currently appreciated. The human genes encoding FPR1, FPR2 and FPR3 are clustered
on chromosome 19q13.3-13.4.

Gene Wiki entry for FPR2 (Formyl peptide receptor 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FPR2 gene promoter:
         AP-1   ATF-2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FPR2 promoter sequence
   Search Chromatin IP Primers for FPR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FPR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3-q13.4   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.3-q13.4

FPR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FPR2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P052264:  view genomic region     (about GC identifiers)

Start:
52,255,279 bp from pter      End:
52,273,779 bp from pter
Size:
18,501 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FPR2_HUMAN, P25090 (See protein sequence)
Recommended Name: N-formyl peptide receptor 2  
Size: 351 amino acids; 38964 Da
Secondary accessions: A8K3E2

Explore the universe of human proteins at neXtProt for FPR2: NX_P25090

Explore proteomics data for FPR2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn4
  • Modification sites at PhosphoSitePlus

  • See FPR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001005738.1  NP_001453.1  

    ENSEMBL proteins: 
     ENSP00000470373   ENSP00000340191   ENSP00000469085   ENSP00000468876   ENSP00000468897  
     ENSP00000472259  
    Reactome Protein details: P25090

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    LTNR: GPCR / Class A : Leukotriene receptors
    FPR: GPCR / Class A : Formyl peptide receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: FPR2/ALX
    Leukotriene receptors
    Formylpeptide receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000826 Formyl_pep_rcpt
     IPR027346 Formyl_pep_1/2_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P25090

    ProtoNet protein and cluster: P25090

    1 Blocks protein domain: IPB000826 Formyl-methionyl peptide receptor signature

    UniProtKB/Swiss-Prot: FPR2_HUMAN, P25090
    Similarity: Belongs to the G-protein coupled receptor 1 family


    FPR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FPR2_HUMAN, P25090
    Function: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic
    factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a
    G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could
    result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4
    (leukotriene B4)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS9054386
    GO:0004982N-formyl peptide receptor activity IEA--
         
    FPR2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FPR2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FPR2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FPR2_HUMAN, P25090: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton1
    extracellular1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    FPR2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FPR2 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    Peptide ligand-binding receptors0.60
    Formyl peptide receptors bind formyl peptides and many other ligands0.00
    G alpha (i) signalling events0.44
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    5Inhibitory action of Lipoxins on Superoxide production in neutrophils
    Inhibitory action of Lipoxins on Superoxide production in neutrophils0.48
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions0.48

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for FPR2
        A-beta Uptake & Degradation

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FPR2 (see all 9)
        Chemokine Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling

    4 GeneGo (Thomson Reuters) Pathways for FPR2
        Inhibitory action of Lipoxins on Superoxide production in neutrophils
    Inhibitory action of Lipoxins on neutrophil migration
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions

    2 BioSystems Pathways for FPR2
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    3 Reactome Pathways for FPR2
        Formyl peptide receptors bind formyl peptides and many other ligands
    G alpha (q) signalling events
    G alpha (i) signalling events


    2 Kegg Pathways  (Kegg details for FPR2):
        Neuroactive ligand-receptor interaction
    Staphylococcus aureus infection


    FPR2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including FPR2: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FPR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FPR2 (P250903 ENSP000003401914) via UniProtKB, MINT, STRING, and/or I2D (see all 249)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MT-RNR2Q8IVG93I2D: score=1 
    ACKR3ENSP000002729284STRING: ENSP00000272928
    ADCY9ENSP000002940164STRING: ENSP00000294016
    ADRBK1ENSP000003122624STRING: ENSP00000312262
    ANXA1ENSP000002574974STRING: ENSP00000257497
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS1374236
    GO:0006935chemotaxis IEA--
    GO:0006954inflammatory response TAS9054386
    GO:0007155cell adhesion TAS9054386
    GO:0007186G-protein coupled receptor signaling pathway TAS9054386

    FPR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for FPR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Boc-MLFFPR1 antagonist[67247-12-5]
    WRW4Selective FPR2 antagonist[878557-55-2]
    MMK 1Potent and selective FPR2 agonist[271246-66-3]
    WKYMVm FPR1, FPR2 and FPR3 receptor agonist [187986-17-0]
    WKYMVMSelective FPR2 and FPR3 receptor agonist[187986-11-4]

    1 HMDB Compound for FPR2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected IUPHAR Ligands for FPR2 (FPR2/ALX) (see all 41)    About this table
    LigandTypeActionAffinityPubmed IDs
    resolvin D1
    AgonistFull agonist11.920080636
    aspirin-triggered resolvin D1
    AgonistFull agonist11.122449948
    WKYMVm
    AgonistFull agonist10.1310586077 11285256 23160941 11035102
    MHC binding peptide
    AgonistFull agonist1010748237
    [3H]LXA4
    AgonistFull agonist9.15 - 9.38006586 1322894
    LXA4
    AgonistPartial agonist8.77 - 9.38006586 1322894
    sCKbeta8-1
    AgonistFull agonist8.85 - 9.1314662730
    MMK-1
    AgonistFull agonist8.79853614 11435499
    PSMalpha3
    AgonistFull agonist8.6720542250
    humanin
    AgonistFull agonist8.4615465011

    Selected Novoseek inferred chemical compound relationships for FPR2 gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lxa4 94.4 58 12806051 (4), 12410796 (4), 8527441 (4), 9151906 (3) (see all 21)
    cyclosporin h 82.4 1 16549058 (1)
    fmlp 78.7 28 1612600 (2), 15187157 (2), 17460114 (2), 9892621 (1) (see all 14)
    n-formylmethionyl-leucylphenylalanine 67.6 5 9299516 (1), 17160341 (1), 17517377 (1), 17460114 (1)
    leukotriene b4 62.4 7 16859643 (2), 10224233 (1), 10818443 (1), 10748237 (1)
    calcium 50.2 49 17651798 (4), 19903830 (3), 17703360 (3), 11316806 (3) (see all 24)
    superoxide 48.1 20 17692291 (3), 18166194 (2), 12920210 (2), 10224233 (1) (see all 10)
    nadph 26.6 5 14744631 (1), 18996352 (1), 12010979 (1), 12950678 (1)
    dexamethasone 19.2 1 17254556 (1)
    lipid 17.7 12 17727628 (2), 10229829 (1), 10748237 (1), 17918787 (1) (see all 9)



    FPR2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FPR2 gene (2 alternative transcripts): 
    NM_001005738.1  NM_001462.3  

    Unigene Cluster for FPR2:

    Formyl peptide receptor 2
    Hs.99855  [show with all ESTs]
    Unigene Representative Sequence: M84562
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000600258 ENST00000340023(uc002pxr.3 uc002pxs.4 uc010epf.3)
    ENST00000599326 ENST00000598953 ENST00000598776 ENST00000600722
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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      QuantiTect SYBR Green Assays in human, mouse, rat FPR2
      QuantiFast Probe-based Assays in human, mouse, rat FPR2

    Additional mRNA sequence: 

    AF054013.1 AK290557.1 BC029125.2 BC071722.1 D10922.1 M76672.1 M84562.1 M88107.1 
    U81501.1 X63819.1 

    3 DOTS entries:

    DT.209652  DT.121504035  DT.121504056 

    20 AceView cDNA sequences:

    BC071722 BI912536 AF054013 U81501 M76672 BC029125 BI907379 BQ025111 
    D10922 BI906624 BX107793 BG541691 M84562 X63819 NM_001462 M88107 
    BM922150 R80041 R79948 BI823232 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FPR2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c
    SP1:              -                           
    SP2:              -     -                     
    SP3:                                          


    ECgene alternative splicing isoforms for FPR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    FPR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTAAGATG
    FPR2 Expression
    About this image

    FPR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FPR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.99855

    UniProtKB/Swiss-Prot: FPR2_HUMAN, P25090
    Tissue specificity: Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis

        Pathway & Disease-focused RT2 Profiler PCR Array including FPR2: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FPR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FPR2 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fpr35
    Fpr21
    formyl peptide receptor 35
    formyl peptide receptor 21
    76.67(n)1
    76.29(a)1
      17 (10.66 cM)5
    142891  NM_008039.21  NP_032065.11 
     178878525 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    34(a)
    1 → many
    GL343604.1(277-1212)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1942026
    zgc:194202
    23(a)
    many ↔ many
    25(3663541-3664584) ENSDARG00000070380


    ENSEMBL Gene Tree for FPR2 (if available)
    TreeFam Gene Tree for FPR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FPR2 gene
    LTB4R2  GPR332  LTB4R22  FPR32  FPR12  C5AR12  GPR322  GPR1522  
    C5AR22  C3AR12  PTGDR22  GPR12  ENSG000002726582  CMKLR12  
    Selected SIMAP similar genes for FPR2 using alignment to 4 protein entries:     FPR2_HUMAN (see all proteins) (see all similar genes):
    FPR3    FPRL2    FPR1    C3AR1    CMKLR1    CXCR2
    GPR32    GPR1    GPR33    PTGDR2    gpcr    C5AR1
    P2RY6    CCR2    P2RY14    CCR7    CCR5    CXCR4

    FPR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FPR2 (see all 301)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs129838701,2
    C,F--52262613(+) GTAAAC/TTATCA 1 -- us2k13Minor allele frequency- T:0.40NA CSA 5
    rs1902324551,2
    --52262652(+) TCTCAC/TTCATA 1 -- us2k10--------
    rs1814339151,2
    --52262833(+) ACTAAC/GCTGCA 1 -- us2k10--------
    rs1863437121,2
    --52262920(+) GAAATA/TCTAAG 1 -- us2k10--------
    rs755048441,2
    C--52262952(+) CCAACC/GAAGAA 1 -- us2k10--------
    rs1505837021,2
    C--52263021(+) GCTCTG/TGTAAA 1 -- us2k10--------
    rs1159370901,2
    C,F--52263135(+) CCTACA/TTGTTC 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1399451381,2
    --52263149(+) CCTCCA/GGATAT 1 -- us2k10--------
    rs116662541,2
    C,F,H--52263162(+) ACTCTA/GGATCC 1 -- us2k128Minor allele frequency- G:0.34NA NS EA CSA WA 3266
    rs801481561,2
    C--52263182(+) AGTTAC/GTGGTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FPR2 (52255279 - 52273779 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for FPR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv458733CNV Gain19166990
    nsv524403CNV Gain19592680
    dgv143e55CNV Gain17911159
    nsv470151CNV Gain18288195
    esv638CNV CNV17122850
    dgv1109e1CNV Complex17122850
    dgv1110e1CNV Complex17122850
    dgv1112e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): FPR2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FPR2
    DNA2.0 Custom Variant and Variant Library Synthesis for FPR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 136538    OMIM disorders: --

    Selected diseases for FPR2 (see all 23):    About MalaCards
    prion disease    bacterial meningitis    amyloidosis    urticaria
    meningitis    alzheimer's disease    synovitis    pertussis
    endotheliitis    endometriosis    dermatitis    astrocytoma
    rheumatoid arthritis    coronary artery disease    arthritis    asthma
    hepatitis b    hiv-1    ovarian cancer    neuronitis

    1 disease from the University of Copenhagen DISEASES database for FPR2:
    Alzheimer's disease

    FPR2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for FPR2 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 53.6 18 17460114 (3), 12806051 (1), 12456400 (1), 14500740 (1) (see all 11)
    alzheimers disease 37.4 18 16219804 (1), 18785269 (1), 16339765 (1), 17237425 (1) (see all 11)
    prion diseases 28.7 4 17114475 (1), 11160182 (1), 18785269 (1)
    neurodegenerative diseases 27 3 15210823 (1), 15670157 (1), 20141570 (1)
    rheumatoid arthritis 19.9 2 19007292 (1), 17918787 (1)
    bacterial infections 17.9 3 15623572 (1), 16493063 (1), 16339765 (1)
    cancer 3.87 2 19491199 (1), 17938258 (1)
    necrosis 1.08 7 15147563 (1), 18458054 (1), 17418999 (1), 17938258 (1) (see all 6)
    dermatitis 0 1 17460114 (1)
    tumors 0 9 17938258 (2), 15829413 (1), 18458054 (1), 9547339 (1) (see all 6)

    Genetic Association Database (GAD): FPR2
    Human Genome Epidemiology (HuGE) Navigator: FPR2 (3 documents)

    Export disorders for FPR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FPR2 gene, integrated from 10 sources (see all 213):
    (articles sorted by number of sources associating them with FPR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. (PubMed id 1612600)1, 2, 9 Bao L.... Gerard C. (Genomics 1992)
    2. Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti- inflammatory receptors. (PubMed id 9151906)1, 2, 9 Takano T....Serhan C.N. (J. Exp. Med. 1997)
    3. A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family. (PubMed id 1373134)1, 2, 9 Murphy P.M....Francke U. (J. Biol. Chem. 1992)
    4. Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor. (PubMed id 9054386)1, 3, 9 Maddox J.F....Serhan C.N. (J. Biol. Chem. 1997)
    5. Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors. (PubMed id 7505609)1, 2, 9 Nomura H.... Matsushima K. (Int. Immunol. 1993)
    6. Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release. (PubMed id 9547339)1, 2, 9 Gronert K.... Serhan C.N. (J. Exp. Med. 1998)
    7. Cloning of a cDNA encoding a receptor related to the formyl peptide receptor of human neutrophils. (PubMed id 1511907)1, 2, 9 Perez H.D.... Andrews W.H. (Gene 1992)
    8. The genetic association of the FPRL1 promoter polymorphism with chronic urticaria in a Korean population. (PubMed id 20642210)1, 4 Yang E.M....Park H.S. (amp 2010)
    9. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2358 HGNC: 3827 AceView: FPRL1 Ensembl:ENSG00000171049 euGenes: HUgn2358
    ECgene: FPR2 Kegg: 2358 H-InvDB: FPR2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FPR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FPR2 gene:
    Search GeneIP for patents involving FPR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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