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Aliases for FPR2 Gene

Aliases for FPR2 Gene

  • Formyl Peptide Receptor 2 2 3 5
  • Formyl Peptide Receptor-Like 1 2 3 4
  • FMLP-Related Receptor I 3 4
  • LXA4 Receptor 3 4
  • FMLP-R-I 3 4
  • FPRL1 3 4
  • FPRH1 3 4
  • LXA4R 3 4
  • HM63 3 4
  • RFP 3 4
  • Lipoxin A4 Receptor (Formyl Peptide Receptor Related) 3
  • N-Formyl Peptide Receptor 2 3
  • Lipoxin A4 Receptor 4
  • FMLP-R-II 3
  • FMLPX 3
  • FPR2A 3
  • FPRH2 3
  • ALXR 3

External Ids for FPR2 Gene

Previous HGNC Symbols for FPR2 Gene

  • FPRL1

Previous GeneCards Identifiers for FPR2 Gene

  • GC19P056955
  • GC19P052264
  • GC19P048595

Summaries for FPR2 Gene

GeneCards Summary for FPR2 Gene

FPR2 (Formyl Peptide Receptor 2) is a Protein Coding gene. Diseases associated with FPR2 include Prion Disease. Among its related pathways are Akt Signaling and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and N-formyl peptide receptor activity. An important paralog of this gene is FPR3.

UniProtKB/Swiss-Prot for FPR2 Gene

  • Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).

Tocris Summary for FPR2 Gene

  • The formyl peptide receptor family, FPR1, FPR2 and FPR3 (formerly FPR, FPRL1 and FPRL2 respectively) are Gi-protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes. FPRs are involved in antibacterial host defence and inflammation.

Gene Wiki entry for FPR2 Gene

Additional gene information for FPR2 Gene

No data available for Entrez Gene Summary , CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FPR2 Gene

Genomics for FPR2 Gene

Regulatory Elements for FPR2 Gene

Enhancers for FPR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H051760 1.3 FANTOM5 Ensembl ENCODE 39.1 +11.4 11418 5.7 CTCF L3MBTL2 CEBPB ZMYM3 CEBPG REST GABPA IRF9 POLR2A CEBPA FPR2 FPR1 SIGLEC10 ZNF350 FPR3 LOC105372448
GH19H051771 1.4 FANTOM5 Ensembl ENCODE dbSUPER 32.5 +19.8 19807 1.1 CTCF POLR2A GABPA FPR2 FPR1 SIGLEC10 ZNF350 SIGLEC14 LOC105372448
GH19H051621 1.3 FANTOM5 ENCODE dbSUPER 34.7 -130.7 -130674 0.3 CTCF MAX BATF POLR2A EED ATF7 ETV6 RUNX3 IKZF2 CREM FPR2 FPR1 SIGLEC10 ZNF350 RPL9P33 ENSG00000273837
GH19H051735 1.4 FANTOM5 Ensembl ENCODE 27.6 -15.8 -15826 1.2 CTCF KLF1 ATF1 TAL1 ZNF175 ZMYM3 CEBPG FOSL1 TCF12 GATA2 FPR1 FPR2 SIGLEC10 ZNF350 SIGLEC14 HAS1
GH19H051748 1 FANTOM5 Ensembl ENCODE 30.7 -1.5 -1526 5 CEBPB FPR1 FPR2 SIGLEC10 FPR3 MIR125A MIR99B MIRLET7E SPACA6 ZNF350 HAS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FPR2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for FPR2 Gene

Genomic Locations for FPR2 Gene
chr19:51,752,026-51,770,670
(GRCh38/hg38)
Size:
18,645 bases
Orientation:
Plus strand
chr19:52,255,279-52,273,779
(GRCh37/hg19)

Genomic View for FPR2 Gene

Genes around FPR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FPR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FPR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FPR2 Gene

Proteins for FPR2 Gene

  • Protein details for FPR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25090-FPR2_HUMAN
    Recommended name:
    N-formyl peptide receptor 2
    Protein Accession:
    P25090
    Secondary Accessions:
    • A8K3E2

    Protein attributes for FPR2 Gene

    Size:
    351 amino acids
    Molecular mass:
    38964 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FPR2 Gene

Post-translational modifications for FPR2 Gene

  • Glycosylation at posLast=44
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FPR2 Gene

Domains & Families for FPR2 Gene

Gene Families for FPR2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for FPR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25090

UniProtKB/Swiss-Prot:

FPR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with FPR2: view

Function for FPR2 Gene

Molecular function for FPR2 Gene

UniProtKB/Swiss-Prot Function:
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).

Phenotypes From GWAS Catalog for FPR2 Gene

Gene Ontology (GO) - Molecular Function for FPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004875 complement receptor activity IBA --
GO:0004930 G-protein coupled receptor activity NAS,IEA 11316806
GO:0004982 N-formyl peptide receptor activity IEA,IBA --
GO:0005124 scavenger receptor binding IPI 20141570
genes like me logo Genes that share ontologies with FPR2: view
genes like me logo Genes that share phenotypes with FPR2: view

Animal Models for FPR2 Gene

MGI Knock Outs for FPR2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FPR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FPR2 Gene

Localization for FPR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FPR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FPR2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for FPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular ISS --
GO:0005737 colocalizes_with cytoplasm IDA 11689470
GO:0005886 plasma membrane ISS,TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with FPR2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FPR2 Gene

Pathways & Interactions for FPR2 Gene

genes like me logo Genes that share pathways with FPR2: view

SIGNOR curated interactions for FPR2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for FPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IGI 20141570
GO:0002430 complement receptor mediated signaling pathway IBA --
GO:0006928 movement of cell or subcellular component TAS 1374236
GO:0006935 chemotaxis TAS 9054386
GO:0006954 inflammatory response TAS 9054386
genes like me logo Genes that share ontologies with FPR2: view

Drugs & Compounds for FPR2 Gene

(58) Drugs for FPR2 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
WKYMVm Pharma Full agonist, Agonist 0
[<sup>125</sup>I-Tyr]Ac2-26 Pharma Agonist 0
[<sup>3</sup>H]LXA<sub>4</sub> Pharma Full agonist, Agonist 0
AG-26 Pharma Full agonist, Agonist 0
annexin I Pharma Full agonist, Agonist 0

(14) Additional Compounds for FPR2 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
amyloid beta<sub>42</sub>
Full agonist, Agonist
PSMalpha3
Full agonist, Agonist
sCKbeta8-1
Full agonist, Agonist

(4) Tocris Compounds for FPR2 Gene

Compound Action Cas Number
FPR A14 FPR agonist 329691-12-5
MMK 1 Potent and selective FPR2 agonist 271246-66-3
N-Formyl-Met-Leu-Phe Endogenous FPR1 agonist 59880-97-6
WKYMVM Selective FPR2 and FPR3 receptor agonist 187986-11-4

(9) ApexBio Compounds for FPR2 Gene

Compound Action Cas Number
Ac9-25 284040-76-2
Boc-MLF 67247-12-5
Cyclosporin H Selective and competitive formyl peptide receptor antagonist 83602-39-5
FPR A14 329691-12-5
MMK 1 271246-66-3
N-Formyl-Met-Leu-Phe 59880-97-6
PBP 10 794466-43-6
WKYMVM 187986-11-4
WRW4 878557-55-2
genes like me logo Genes that share compounds with FPR2: view

Drug Products

Transcripts for FPR2 Gene

Unigene Clusters for FPR2 Gene

Formyl peptide receptor 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FPR2

Alternative Splicing Database (ASD) splice patterns (SP) for FPR2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c
SP1: -
SP2: - -
SP3:

Relevant External Links for FPR2 Gene

GeneLoc Exon Structure for
FPR2
ECgene alternative splicing isoforms for
FPR2

Expression for FPR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FPR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FPR2 Gene

This gene is overexpressed in Whole Blood (x46.2).

Protein differential expression in normal tissues from HIPED for FPR2 Gene

This gene is overexpressed in Monocytes (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FPR2 Gene



Protein tissue co-expression partners for FPR2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FPR2 Gene:

FPR2

SOURCE GeneReport for Unigene cluster for FPR2 Gene:

Hs.99855

mRNA Expression by UniProt/SwissProt for FPR2 Gene:

P25090-FPR2_HUMAN
Tissue specificity: Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.

Evidence on tissue expression from TISSUES for FPR2 Gene

  • Blood(4.9)
  • Heart(4.4)
  • Bone marrow(4.3)
  • Lung(2.8)
  • Spleen(2.7)
  • Intestine(2)
genes like me logo Genes that share expression patterns with FPR2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FPR2 Gene

Orthologs for FPR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FPR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FPR2 33 34
  • 99.43 (n)
dog
(Canis familiaris)
Mammalia FPR2 33
  • 86.23 (n)
mouse
(Mus musculus)
Mammalia Fpr2 33 16 34
  • 76.67 (n)
Fpr3 34
  • 74 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fpr2 33
  • 76.54 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 48 (a)
ManyToMany
-- 34
  • 45 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 34 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:194202 34
  • 23 (a)
ManyToMany
Species where no ortholog for FPR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FPR2 Gene

ENSEMBL:
Gene Tree for FPR2 (if available)
TreeFam:
Gene Tree for FPR2 (if available)

Paralogs for FPR2 Gene

Variants for FPR2 Gene

Sequence variations from dbSNP and Humsavar for FPR2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000288991 -- 51,767,826(+) AAACC(A/G)GATCC intron-variant
rs1000301661 -- 51,761,236(+) GTAAG(C/T)TGGGG intron-variant
rs1000400153 -- 51,752,390(+) AGCTC(A/T)TTTGT intron-variant, upstream-variant-2KB
rs1000806940 -- 51,768,099(+) GTGAC(G/T)CCTCA intron-variant
rs1000822672 -- 51,764,003(+) ATCCA(C/T)TTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FPR2 Gene

Variant ID Type Subtype PubMed ID
dgv1067e212 CNV gain 25503493
dgv143e55 CNV gain 17911159
dgv3625n100 CNV gain 25217958
dgv3626n100 CNV gain 25217958
dgv6523n54 CNV gain 21841781
esv2758767 CNV gain+loss 17122850
nsv1140251 OTHER inversion 24896259
nsv458733 CNV gain 19166990
nsv470151 CNV gain 18288195
nsv524403 CNV gain 19592680
nsv579997 CNV gain 21841781

Variation tolerance for FPR2 Gene

Residual Variation Intolerance Score: 35.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FPR2 Gene

Human Gene Mutation Database (HGMD)
FPR2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FPR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FPR2 Gene

Disorders for FPR2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FPR2 Gene - From: HGMD, DISEASES, and Novoseek

Disorder Aliases PubMed IDs
prion disease
  • prion disease pathway
- elite association - COSMIC cancer census association via MalaCards
Search FPR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FPR2

Genetic Association Database (GAD)
FPR2
Human Genome Epidemiology (HuGE) Navigator
FPR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FPR2
genes like me logo Genes that share disorders with FPR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FPR2 Gene

Publications for FPR2 Gene

  1. Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release. (PMID: 9547339) Gronert K … Serhan CN (The Journal of experimental medicine 1998) 3 4 22 60
  2. Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor. (PMID: 9054386) Maddox JF … Serhan CN (The Journal of biological chemistry 1997) 2 3 22 60
  3. Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. (PMID: 9151906) Takano T … Serhan CN (The Journal of experimental medicine 1997) 3 4 22 60
  4. A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family. (PMID: 1373134) Murphy PM … Francke U (The Journal of biological chemistry 1992) 3 4 22 60
  5. Cloning of a cDNA encoding a receptor related to the formyl peptide receptor of human neutrophils. (PMID: 1511907) Perez HD … Andrews WH (Gene 1992) 3 4 22 60

Products for FPR2 Gene

Sources for FPR2 Gene

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