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Aliases for FPR2 Gene

Aliases for FPR2 Gene

  • Formyl Peptide Receptor 2 2 3
  • Formyl Peptide Receptor-Like 1 2 3 4
  • FPRH1 3 4 6
  • FPRL1 3 4 6
  • LXA4R 3 4 6
  • HM63 3 4 6
  • FMLP-Related Receptor I 3 4
  • LXA4 Receptor 3 4
  • FMLP-R-I 3 4
  • RFP 3 4
  • Lipoxin A4 Receptor (Formyl Peptide Receptor Related) 3
  • N-Formyl Peptide Receptor 2 3
  • Lipoxin A4 Receptor 4
  • FMLP-R-II 3
  • FPRH2 3
  • FMLPX 3
  • FPR2A 3
  • ALXR 3

External Ids for FPR2 Gene

Previous Symbols for FPR2 Gene

  • FPRL1

Summaries for FPR2 Gene

GeneCards Summary for FPR2 Gene

FPR2 (Formyl Peptide Receptor 2) is a Protein Coding gene. Diseases associated with FPR2 include amyloidosis and bacterial meningitis. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include G-protein coupled receptor activity and N-formyl peptide receptor activity. An important paralog of this gene is CMKLR1.

UniProtKB/Swiss-Prot for FPR2 Gene

  • Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4)

Tocris Summary for FPR2 Gene

  • The formyl peptide receptor family, FPR1, FPR2 and FPR3 (formerly FPR, FPRL1 and FPRL2 respectively) are Gi protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes and found at lower expression levels on endothelial cells, neurons, astrocytes and hepatocytes. Formyl peptide receptors are involved in antibacterial host defence and inflammation. Activation of FPRs mediates induction of neutrophil chemotaxis, production of reactive oxygen species (ROS) to clear damaged cells and stimulation of degranulation of neutrophils. In addition, FPRs have a role in neutrophil transcriptional regulation and cytokine production, and induce neutrophil apoptosis in a ROS-dependent manner. Recently, FPRs have been implicated in the pathogenesis of amyloidosis, Alzheimers disease, prion diseases and HIV. Ligand diversity is a prominent and unusual feature of FPR family receptors, suggesting that these receptors may have more complex functions than are currently appreciated. The human genes encoding FPR1, FPR2 and FPR3 are clustered on chromosome 19q13.3-13.4.

Gene Wiki entry for FPR2 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FPR2 Gene

Genomics for FPR2 Gene

Genomic Location for FPR2 Gene

Start:
51,752,026 bp from pter
End:
51,770,526 bp from pter
Size:
18,501 bases
Orientation:
Plus strand

Genomic View for FPR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FPR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FPR2 Gene

Regulatory Elements for FPR2 Gene

Proteins for FPR2 Gene

  • Protein details for FPR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25090-FPR2_HUMAN
    Recommended name:
    N-formyl peptide receptor 2
    Protein Accession:
    P25090
    Secondary Accessions:
    • A8K3E2

    Protein attributes for FPR2 Gene

    Size:
    351 amino acids
    Molecular mass:
    38964 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FPR2 Gene

Proteomics data for FPR2 Gene at MOPED

Post-translational modifications for FPR2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn4

Other Protein References for FPR2 Gene

No data available for DME Specific Peptides for FPR2 Gene

Domains for FPR2 Gene

Gene Families for FPR2 Gene

HGNC:
  • LTNR :GPCR / Class A : Leukotriene receptors
  • FPR :GPCR / Class A : Formyl peptide receptors
IUPHAR :

UniProtKB/Swiss-Prot:

FPR2_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P25090
genes like me logo Genes that share domains with FPR2: view

Function for FPR2 Gene

Molecular function for FPR2 Gene

UniProtKB/Swiss-Prot Function: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4)

Gene Ontology (GO) - Molecular Function for FPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 9054386
GO:0004982 N-formyl peptide receptor activity IEA --
genes like me logo Genes that share ontologies with FPR2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FPR2 Gene

Localization for FPR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FPR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FPR2 Gene COMPARTMENTS Subcellular localization image for FPR2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FPR2: view

Pathways for FPR2 Gene

genes like me logo Genes that share pathways with FPR2: view

Interacting Proteins for FPR2 Gene

Gene Ontology (GO) - Biological Process for FPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 1374236
GO:0006935 chemotaxis IEA --
GO:0006954 inflammatory response TAS 9054386
GO:0007155 cell adhesion TAS 9054386
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with FPR2: view

Compounds for FPR2 Gene

(5) Tocris Compounds for FPR2 Gene

Compound Action Cas Number
Boc-MLF FPR1 antagonist [67247-12-5]
MMK 1 Potent and selective FPR2 agonist [271246-66-3]
WKYMVm FPR1, FPR2 and FPR3 receptor agonist [187986-17-0]
WKYMVm FPR1, FPR2 and FPR3 receptor agonist [187986-17-0]
WRW4 Selective FPR2 antagonist [878557-55-2]

(1) HMDB Compounds for FPR2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(41) IUPHAR Ligand for FPR2 Gene

Ligand Type Action Affinity Pubmed IDs
resolvin D1 Agonist Full agonist 11.9
aspirin-triggered resolvin D1 Agonist Full agonist 11.1
fMet-Leu-Phe Agonist Full agonist 10.2
MHC binding peptide Agonist Full agonist 10
[3H]LXA4 Agonist Full agonist 9.3
LXA4 Agonist Partial agonist 9.3
sCKbeta8-1 Agonist Full agonist 9.13
humanin Agonist Full agonist 8.95
MMK-1 Agonist Full agonist 8.7
PSMalpha3 Agonist Full agonist 8.67
fMet-Ile-Val-Thr-Leu-Phe Agonist Full agonist 8.6
SHAAGtide Agonist Full agonist 7.72
pyrazolone, 1 Agonist Full agonist 7.4
T21/DP107 Agonist Full agonist 7.3
compound 1754-31 Antagonist Antagonist 7.09
uPar fragment Agonist Full agonist 7.08
amyloid beta42 Agonist Full agonist 7
PBP10 Allosteric regulator Positive 7
annexin I-(2-26) Agonist Full agonist 7
CGEN-855A Agonist Full agonist 6.72
serum amyloid A Agonist Full agonist 6.6
t-Boc-FLFLF Antagonist Antagonist 6.6
annexin I Agonist Full agonist 6.5
AG-26 Agonist Full agonist 6.3
compound R-(-)-5f [PMID: 22607879] Agonist Full agonist 6.27
fMet-Met-Tyr-Ala-Leu-Phe Agonist Full agonist 6
WRWWWW Antagonist Antagonist 6
isopropylureido-FLFLF Antagonist Antagonist 6
LL-37 Agonist Full agonist 6
[125I-Tyr]Ac2-26 Agonist Agonist 5.89
quin-C1 Agonist Full agonist 5.72
WKYMVm Agonist Full agonist 5.52
quin-C7 Antagonist Antagonist 5.18
Hp(2-20) Agonist Full agonist 5
PrP106-126 Agonist Agonist 4.6
FPRL1-inhibitor protein Antagonist Antagonist
F peptide Agonist Full agonist
ATLa2 Agonist Full agonist
N36 Agonist Full agonist
V3 peptide Agonist Full agonist
aspirin triggered lipoxin A4 Agonist Full agonist

(20) Novoseek inferred chemical compound relationships for FPR2 Gene

Compound -log(P) Hits PubMed IDs
lxa4 94.4 37
cyclosporin h 82.4 1
fmlp 78.7 17
n-formylmethionyl-leucylphenylalanine 67.6 4
leukotriene b4 62.4 5
genes like me logo Genes that share compounds with FPR2: view

Transcripts for FPR2 Gene

mRNA/cDNA for FPR2 Gene

Unigene Clusters for FPR2 Gene

Formyl peptide receptor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FPR2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c
SP1: -
SP2: - -
SP3:

Relevant External Links for FPR2 Gene

GeneLoc Exon Structure for
FPR2
ECgene alternative splicing isoforms for
FPR2

Expression for FPR2 Gene

mRNA expression in normal human tissues for FPR2 Gene

mRNA differential expression in normal tissues according to GTEx for FPR2 Gene

This gene is overexpressed in Whole Blood (46.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FPR2 Gene

SOURCE GeneReport for Unigene cluster for FPR2 Gene Hs.99855

mRNA Expression by UniProt/SwissProt for FPR2 Gene

P25090-FPR2_HUMAN
Tissue specificity: Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.
genes like me logo Genes that share expressions with FPR2: view

Orthologs for FPR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FPR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FPR2 36
  • 99.43 (n)
  • 99.43 (a)
FPR2 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FPR2 36
  • 86.23 (n)
  • 86.04 (a)
mouse
(Mus musculus)
Mammalia Fpr2 36
  • 76.67 (n)
  • 76.29 (a)
Fpr2 37
  • 76 (a)
OneToMany
Fpr3 16
Fpr3 37
  • 74 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 48 (a)
ManyToMany
-- 37
  • 45 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Fpr2 36
  • 76.54 (n)
  • 75.78 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 34 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:194202 37
  • 23 (a)
ManyToMany
Species with no ortholog for FPR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FPR2 Gene

ENSEMBL:
Gene Tree for FPR2 (if available)
TreeFam:
Gene Tree for FPR2 (if available)

Paralogs for FPR2 Gene

genes like me logo Genes that share paralogs with FPR2: view

Variants for FPR2 Gene

Sequence variations from dbSNP and Humsavar for FPR2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2198168 -- 51,770,615(+) ttttg(G/T)ttttt downstream-variant-500B
rs3764541 -- 51,768,503(-) ACGGT(A/G)CTATA intron-variant
rs4801893 -- 51,762,819(+) CCATG(G/T)ACACA intron-variant, upstream-variant-2KB
rs4801894 -- 51,765,591(+) CTTGG(C/T)GTGTG intron-variant
rs4802863 -- 51,765,719(+) TCCCA(C/T)TTGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FPR2 Gene

Variant ID Type Subtype PubMed ID
dgv1109e1 CNV Complex 17122850
esv638 CNV CNV 17122850
dgv1110e1 CNV Complex 17122850
nsv524403 CNV Gain 19592680
nsv470151 CNV Gain 18288195
nsv458733 CNV Gain 19166990
dgv143e55 CNV Gain 17911159
dgv1112e1 CNV Complex 17122850

Relevant External Links for FPR2 Gene

HapMap Linkage Disequilibrium report
FPR2
Human Gene Mutation Database (HGMD)
FPR2

Disorders for FPR2 Gene

(1) University of Copenhagen DISEASES for FPR2 Gene

(11) Novoseek inferred disease relationships for FPR2 Gene

Disease -log(P) Hits PubMed IDs
inflammation 53.6 13
alzheimers disease 37.4 11
prion diseases 28.7 3
neurodegenerative diseases 27 3
rheumatoid arthritis 19.9 2

Relevant External Links for FPR2

Genetic Association Database (GAD)
FPR2
Human Genome Epidemiology (HuGE) Navigator
FPR2
genes like me logo Genes that share disorders with FPR2: view

No data available for UniProtKB/Swiss-Prot for FPR2 Gene

Publications for FPR2 Gene

  1. A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family. (PMID: 1373134) Murphy P.M. … Francke U. (J. Biol. Chem. 1992) 3 4 23
  2. Cloning of a cDNA encoding a receptor related to the formyl peptide receptor of human neutrophils. (PMID: 1511907) Perez H.D. … Andrews W.H. (Gene 1992) 3 4 23
  3. Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. (PMID: 1612600) Bao L. … Gerard C. (Genomics 1992) 3 4 23
  4. Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor. (PMID: 9054386) Maddox J.F. … Serhan C.N. (J. Biol. Chem. 1997) 2 3 23
  5. Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti- inflammatory receptors. (PMID: 9151906) Takano T. … Serhan C.N. (J. Exp. Med. 1997) 3 4 23

Products for FPR2 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate FPR2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for FPR2
    • Block miRNA regulation of FPR2 using miScript Target Protectors

    Sources for FPR2 Gene

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