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Aliases for FPR2 Gene

Aliases for FPR2 Gene

  • Formyl Peptide Receptor 2 2 3 5
  • Formyl Peptide Receptor-Like 1 2 3 4
  • FMLP-Related Receptor I 3 4
  • LXA4 Receptor 3 4
  • FMLP-R-I 3 4
  • FPRL1 3 4
  • FPRH1 3 4
  • LXA4R 3 4
  • HM63 3 4
  • RFP 3 4
  • Lipoxin A4 Receptor (Formyl Peptide Receptor Related) 3
  • Lipoxin A4 Receptor 4
  • FMLP-R-II 3
  • FMLPX 3
  • FPR2A 3
  • FPRH2 3
  • ALXR 3

External Ids for FPR2 Gene

Previous HGNC Symbols for FPR2 Gene

  • FPRL1

Previous GeneCards Identifiers for FPR2 Gene

  • GC19P056955
  • GC19P052264
  • GC19P048595

Summaries for FPR2 Gene

GeneCards Summary for FPR2 Gene

FPR2 (Formyl Peptide Receptor 2) is a Protein Coding gene. Diseases associated with FPR2 include prion disease. Among its related pathways are Signaling by GPCR and A-beta Pathways: Uptake and Degradation. GO annotations related to this gene include G-protein coupled receptor activity and N-formyl peptide receptor activity. An important paralog of this gene is CMKLR1.

UniProtKB/Swiss-Prot for FPR2 Gene

  • Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).

Tocris Summary for FPR2 Gene

  • The formyl peptide receptor family, FPR1, FPR2 and FPR3 (formerly FPR, FPRL1 and FPRL2 respectively) are Gi-protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes. FPRs are involved in antibacterial host defence and inflammation.

Gene Wiki entry for FPR2 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FPR2 Gene

Genomics for FPR2 Gene

Regulatory Elements for FPR2 Gene

Promoters for FPR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FPR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FPR2 Gene

Chromosome:
19
Start:
51,752,026 bp from pter
End:
51,770,670 bp from pter
Size:
18,645 bases
Orientation:
Plus strand

Genomic View for FPR2 Gene

Genes around FPR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FPR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FPR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FPR2 Gene

Proteins for FPR2 Gene

  • Protein details for FPR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25090-FPR2_HUMAN
    Recommended name:
    N-formyl peptide receptor 2
    Protein Accession:
    P25090
    Secondary Accessions:
    • A8K3E2

    Protein attributes for FPR2 Gene

    Size:
    351 amino acids
    Molecular mass:
    38964 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FPR2 Gene

Proteomics data for FPR2 Gene at MOPED

Post-translational modifications for FPR2 Gene

  • Glycosylation at Asn 4
  • Modification sites at PhosphoSitePlus

Other Protein References for FPR2 Gene

Antibody Products

No data available for DME Specific Peptides for FPR2 Gene

Domains & Families for FPR2 Gene

Suggested Antigen Peptide Sequences for FPR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25090

UniProtKB/Swiss-Prot:

FPR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with FPR2: view

Function for FPR2 Gene

Molecular function for FPR2 Gene

UniProtKB/Swiss-Prot Function:
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).
genes like me logo Genes that share phenotypes with FPR2: view

Animal Models for FPR2 Gene

MGI Knock Outs for FPR2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FPR2 Gene

Localization for FPR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FPR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FPR2 Gene COMPARTMENTS Subcellular localization image for FPR2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for FPR2 Gene

Pathways & Interactions for FPR2 Gene

genes like me logo Genes that share pathways with FPR2: view

Interacting Proteins for FPR2 Gene

SIGNOR curated interactions for FPR2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for FPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 1374236
GO:0007155 cell adhesion TAS 9054386
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with FPR2: view

Drugs & Compounds for FPR2 Gene

(49) Drugs for FPR2 Gene - From: IUPHAR, DGIdb, Tocris, Novoseek, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
WKYMVM Pharma Full agonist, Agonist Selective FPR2 and FPR3 receptor agonist 0
[<sup>125</sup>I-Tyr]Ac2-26 Pharma Agonist 0
[<sup>3</sup>H]LXA<sub>4</sub> Pharma Full agonist, Agonist 0
AG-26 Pharma Full agonist, Agonist 0
annexin I Pharma Full agonist, Agonist 0

(19) Additional Compounds for FPR2 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
amyloid beta<sub>42</sub>
Full agonist, Agonist
PSMalpha3
Full agonist, Agonist
sCKbeta8-1
Full agonist, Agonist
FPR A14
329691-12-5
MMK 1
271246-66-3

(4) Tocris Compounds for FPR2 Gene

Compound Action Cas Number
FPR A14 FPR agonist 329691-12-5
MMK 1 Potent and selective FPR2 agonist 271246-66-3
N-Formyl-Met-Leu-Phe Endogenous FPR1 agonist 59880-97-6
WKYMVM Selective FPR2 and FPR3 receptor agonist 187986-11-4
genes like me logo Genes that share compounds with FPR2: view

Transcripts for FPR2 Gene

Unigene Clusters for FPR2 Gene

Formyl peptide receptor 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FPR2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c
SP1: -
SP2: - -
SP3:

Relevant External Links for FPR2 Gene

GeneLoc Exon Structure for
FPR2
ECgene alternative splicing isoforms for
FPR2

Expression for FPR2 Gene

mRNA expression in normal human tissues for FPR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FPR2 Gene

This gene is overexpressed in Whole Blood (x46.2).

Protein differential expression in normal tissues from HIPED for FPR2 Gene

This gene is overexpressed in Monocytes (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FPR2 Gene



SOURCE GeneReport for Unigene cluster for FPR2 Gene Hs.99855

mRNA Expression by UniProt/SwissProt for FPR2 Gene

P25090-FPR2_HUMAN
Tissue specificity: Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.
genes like me logo Genes that share expression patterns with FPR2: view

Protein tissue co-expression partners for FPR2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for FPR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FPR2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia FPR2 35
  • 86.23 (n)
  • 86.04 (a)
mouse
(Mus musculus)
Mammalia Fpr2 35
  • 76.67 (n)
  • 76.29 (a)
Fpr2 16
Fpr2 36
  • 76 (a)
OneToMany
Fpr3 36
  • 74 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia FPR2 35
  • 99.43 (n)
  • 99.43 (a)
FPR2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fpr2 35
  • 76.54 (n)
  • 75.78 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 48 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 34 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:194202 36
  • 23 (a)
ManyToMany
Species with no ortholog for FPR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FPR2 Gene

ENSEMBL:
Gene Tree for FPR2 (if available)
TreeFam:
Gene Tree for FPR2 (if available)

Paralogs for FPR2 Gene

Paralogs for FPR2 Gene

genes like me logo Genes that share paralogs with FPR2: view

Variants for FPR2 Gene

Sequence variations from dbSNP and Humsavar for FPR2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2198168 -- 51,770,615(+) ttttg(G/T)ttttt downstream-variant-500B, utr-variant-3-prime
rs4801893 -- 51,762,819(+) CCATG(G/T)ACACA intron-variant, upstream-variant-2KB
rs4801894 -- 51,765,591(+) CTTGG(C/T)GTGTG intron-variant
rs3764541 -- 51,768,503(-) ACGGT(A/G)CTATA intron-variant
rs4802863 -- 51,765,719(+) TCCCA(C/T)TTGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FPR2 Gene

Variant ID Type Subtype PubMed ID
dgv1109e1 CNV Complex 17122850
esv638 CNV CNV 17122850
dgv1110e1 CNV Complex 17122850
nsv524403 CNV Gain 19592680
nsv470151 CNV Gain 18288195
nsv458733 CNV Gain 19166990
dgv143e55 CNV Gain 17911159
dgv1112e1 CNV Complex 17122850

Variation tolerance for FPR2 Gene

Residual Variation Intolerance Score: 35.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FPR2 Gene

HapMap Linkage Disequilibrium report
FPR2
Human Gene Mutation Database (HGMD)
FPR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FPR2 Gene

Disorders for FPR2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FPR2 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
prion disease
  • prion disease pathway
- elite association - COSMIC cancer census association via MalaCards
Search FPR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FPR2

Genetic Association Database (GAD)
FPR2
Human Genome Epidemiology (HuGE) Navigator
FPR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FPR2
genes like me logo Genes that share disorders with FPR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FPR2 Gene

Publications for FPR2 Gene

  1. Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. (PMID: 1612600) Bao L. … Gerard C. (Genomics 1992) 3 4 23 67
  2. Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor. (PMID: 9054386) Maddox J.F. … Serhan C.N. (J. Biol. Chem. 1997) 2 3 23
  3. The FPR2-specific ligand MMK-1 activates the neutrophil NADPH-oxidase, but triggers no unique pathway for opening of plasma membrane calcium channels. (PMID: 19282028) Karlsson J. … Dahlgren C. (Cell Calcium 2009) 3 23
  4. Lysophosphatidylglycerol inhibits formyl peptide receptorlike-1-stimulated chemotactic migration and IL-1beta production from human phagocytes. (PMID: 19381066) Shim J.W. … Bae Y.S. (Exp. Mol. Med. 2009) 3 23
  5. Lipoxin A4 receptor dependent leishmania infection. (PMID: 19811292) Wenzel A. … Van Zandbergen G. (Autoimmunity 2009) 3 23

Products for FPR2 Gene

Sources for FPR2 Gene

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