Aliases for FPR2 Gene
External Ids for FPR2 Gene
Previous HGNC Symbols for FPR2 Gene
Previous GeneCards Identifiers for FPR2 Gene
GeneCards Summary for FPR2 Gene
FPR2 (Formyl Peptide Receptor 2) is a Protein Coding gene. Diseases associated with FPR2 include bacterial meningitis and amyloidosis. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include G-protein coupled receptor activity and N-formyl peptide receptor activity. An important paralog of this gene is CMKLR1.
UniProtKB/Swiss-Prot for FPR2 Gene
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4)
The formyl peptide receptor family, FPR1, FPR2 and FPR3 (formerly FPR, FPRL1 and FPRL2 respectively) are Gi protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes and found at lower expression levels on endothelial cells, neurons, astrocytes and hepatocytes. Formyl peptide receptors are involved in antibacterial host defence and inflammation. Activation of FPRs mediates induction of neutrophil chemotaxis, production of reactive oxygen species (ROS) to clear damaged cells and stimulation of degranulation of neutrophils. In addition, FPRs have a role in neutrophil transcriptional regulation and cytokine production, and induce neutrophil apoptosis in a ROS-dependent manner. Recently, FPRs have been implicated in the pathogenesis of amyloidosis, Alzheimer's disease, prion diseases and HIV. Ligand diversity is a prominent and unusual feature of FPR family receptors, suggesting that these receptors may have more complex functions than are currently appreciated. The human genes encoding FPR1, FPR2 and FPR3 are clustered on chromosome 19q13.3-13.4.