FPR2 Gene
protein-coding GIFtS: 63
GCID: GC19P052264
|
|
formyl peptide receptor 2(Previous name: formyl peptide receptor-like 1 )
(Previous symbol: FPRL1)
| |
Aliases
for FPR2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Formyl Peptide Receptor 21 2 | | FPR2A1 2 | | FPRL11 2 3 5 | | FPRH21 2 | | HM631 2 3 5 | | FMLP-R-I2 3 | | LXA4R1 2 3 5 | | RFP2 3 | | Formyl Peptide Receptor-Like 11 2 3 | | FMLP-Related Receptor I2 3 | | FPRH12 3 5 | | LXA4 Receptor2 3 | | ALXR1 2 | | Lipoxin A4 Receptor (Formyl Peptide Receptor Related)2 | | FMLP-R-II1 2 | | N-Formyl Peptide Receptor 22 | | FMLPX1 2 | | Lipoxin A4 Receptor3 |
Export aliases for FPR2 gene to outside databasesPrevious GC identifers: GC19P056955 GC19P048595 |
Summaries
for FPR2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FPR2_HUMAN, P25090Function: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors.Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein thatactivates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in ananti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4)
 summary
for FPR2: The formyl peptide receptor family, FPR1, FPR2 and FPR3 (formerly FPR, FPRL1 and FPRL2 respectively) are Gi
protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes and found at lower
expression levels on endothelial cells, neurons, astrocytes and hepatocytes. Formyl peptide receptors are
involved in antibacterial host defence and inflammation. Activation of FPRs mediates induction of neutrophil
chemotaxis, production of reactive oxygen species (ROS) to clear damaged cells and stimulation of
degranulation of neutrophils. In addition, FPRs have a role in neutrophil transcriptional regulation and
cytokine production, and induce neutrophil apoptosis in a ROS-dependent manner. Recently, FPRs have been
implicated in the pathogenesis of amyloidosis, Alzheimer's disease, prion diseases and HIV. Ligand diversity
is a prominent and unusual feature of FPR family receptors, suggesting that these receptors may have more
complex functions than are currently appreciated. The human genes encoding FPR1, FPR2 and FPR3 are clustered
on chromosome 19q13.3-13.4.
Gene Wiki entry for FPR2 (Formyl peptide receptor 2)
|
Genomic Views
for FPR2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FPR2 gene promoter:
AP-1 ATF-2 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for FPR2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FPR2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.3-q13.4 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13.3-q13.4FPR2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P052264: view genomic region
(about GC identifiers)
Start:
|
52,264,183 bp from pter |
End:
|
52,273,779 bp from pter |
Size:
|
9,597 bases |
Orientation:
|
plus strand |
|
Proteins
for FPR2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FPR2_HUMAN, P25090 (See
protein sequence)Recommended Name: N-formyl peptide receptor 2 Size: 351 amino acids; 38964 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: A8K3E2Explore the universe of human proteins at neXtProt for FPR2: NX_P25090
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P25090
FPR2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001005738.1 NP_001453.1
ENSEMBL proteins: ENSP00000340191 Reactome Protein details: P25090
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
FPR2 for ontologies About GeneDecksing
FPR2 Antibody Products:
Assay Products for FPR2: |
Protein
Domains /
Families
for FPR2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FPR2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P25090ProtoNet protein and cluster: P25090 1 Blocks protein family: IPB000826 Formyl-methionyl peptide receptor signature
UniProtKB/Swiss-Prot: FPR2_HUMAN, P25090Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for FPR2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FPR2_HUMAN, P25090Function: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors.Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein thatactivates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in ananti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4)
Clone
Products: |  | EMD Millipore Clones for the Expression of FPR2 | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FPR2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FPR2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): FPR2 (NM_001462) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FPR2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FPR2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FPR2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
TAS | 9054386 | | GO:0004982 | N-formyl peptide receptor activity |
IEA | -- |
FPR2 for ontologies About GeneDecksing
|
Pathways & Interactions
for FPR2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | Inhibitory action of Lipoxins on Superoxide production in neutrophils | | | 4 | G alpha (q) signalling events | | | 5 | Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for FPR2
1  R&D Systems Pathway for FPR2
4  GeneGo (Thomson Reuters) Pathways for FPR2
2  BioSystems Pathways for FPR2
5/10 
Reactome Pathways for FPR2 (see all 10)
2 
Kegg Pathways (Kegg details for FPR2):
FPR2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FPR2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/249 Interacting proteins for FPR2 (P250903 ENSP000003401914) via UniProtKB, MINT, STRING, and/or I2D (see all 249)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
FPR2 for ontologies About GeneDecksing
|
Drugs & Compounds
for FPR2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
FPR2 for compounds About GeneDecksing
Compounds for FPR2 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| MMK 1 | Potent and selective FPR2 agonist | [271246-66-3] | | WKYMVm | FPR1, FPR2 and FPR3 receptor agonist | [187986-17-0] | | N-Formyl-Met-Leu-Phe | Endogenous FPR1 agonist | [59880-97-6] |
1 HMDB Compound for FPR2 About this table
10/20 Novoseek chemical compound relationships for FPR2 gene (see all 20) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| lxa4 |
94.4 |
58 |
12806051 (4), 12410796 (4), 8527441 (4), 9151906 (3) (see all 21) |
| cyclosporin h |
82.4 |
1 |
16549058 (1) |
| fmlp |
78.7 |
28 |
1612600 (2), 15187157 (2), 17460114 (2), 9892621 (1) (see all 14) |
| n-formylmethionyl-leucylphenylalanine |
67.6 |
5 |
9299516 (1), 17160341 (1), 17517377 (1), 17460114 (1) |
| leukotriene b4 |
62.4 |
7 |
16859643 (2), 10224233 (1), 10818443 (1), 10748237 (1) |
| calcium |
50.2 |
49 |
17651798 (4), 19903830 (3), 17703360 (3), 11316806 (3) (see all 24) |
| superoxide |
48.1 |
20 |
17692291 (3), 18166194 (2), 12920210 (2), 10224233 (1) (see all 10) |
| nadph |
26.6 |
5 |
14744631 (1), 18996352 (1), 12010979 (1), 12950678 (1) |
| dexamethasone |
19.2 |
1 |
17254556 (1) |
| lipid |
17.7 |
12 |
17727628 (2), 10229829 (1), 10748237 (1), 17918787 (1) (see all 9) |
Search CenterWatch for drugs/clinical trials and news about FPR2
|
Transcripts
for FPR2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FPR2 gene (2 alternative transcripts): NM_001005738.1 NM_001462.3 Unigene Cluster for FPR2: Formyl peptide receptor 2 Hs.99855 [show with all ESTs]Unigene Representative Sequence: M845621 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000340023(uc002pxr.3 uc002pxs.4 uc010epf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FPR2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FPR2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FPR2 (NM_001462) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FPR2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FPR2 |
Additional cDNA sequence: AF054013.1 AK290557.1 BC029125.2 BC071722.1 D10922.1 M76672.1 M84562.1 M88107.1 U81501.1 X63819.1 3 DOTS entries: DT.209652 DT.121504035 DT.121504056 20 AceView cDNA sequences: BI912536 M76672 BC029125 AF054013 U81501 BC071722 BG541691 BM922150 BX107793 M84562 M88107 X63819 NM_001462 BQ025111 D10922 BI907379 BI906624 R80041 R79948 BI823232
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for FPR2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c |
|---|
|
| SP1: | | | | | - | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FPR2
|
Expression
for FPR2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FPR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTAAGATG
About this image
See FPR2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FPR2
SOURCE GeneReport for Unigene cluster: Hs.99855
UniProtKB/Swiss-Prot: FPR2_HUMAN, P25090Tissue specificity: Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis
SABiosciences Expression via Pathway-Focused PCR Array including FPR2: | G Protein Coupled Receptors 384HT in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FPR2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FPR2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FPR2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FPR2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FPR2 |
Orthologs
for FPR2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FPR2 gene from 2/7 species (see all 7) About this table
ENSEMBL Gene Tree for FPR2 (if available)
TreeFam Gene Tree for FPR2 (if available) |
Paralogs
for FPR2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FPR2 gene
- LTB4R2 LTB4R22 FPR32 FPR12 C5AR12 GPR322 GPR1522 C5AR22
- C3AR12 PTGDR22 GPR12 CMKLR12
18/26 SIMAP similar genes for FPR2 using alignment to 4 protein entries: FPR2_HUMAN (see all proteins)
(see all similar genes):FPR3 FPRL2 FPR1 GPR32 GPR33 PTGDR2
gpcr C5AR1 GPR1 CMKLR1 CXCR4 CXCR2
IL8RB AGTR1 CCR9 CXCR1 OPRM1 CCR4
FPR2 for paralogs About GeneDecksing
|
Genomic Variants
for FPR2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FPR2 (52264183 - 52273779 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for FPR2
4 CNVs: 8875 3195 34482 4085
Human Gene Mutation Database (HGMD): FPR2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FPR2 |
|
Disorders
/ Diseases
for FPR2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FPR2 for disorders About GeneDecksing
OMIM gene information: 136538
OMIM disorders: --
20  diseases for FPR2: About MalaCardsprion disease alzheimer's disease amyloidosis bacterial meningitis
rheumatoid arthritis neurodegenerative disease neuronitis meningitis
urticaria synovitis dermatitis hepatitis b
arthritis pertussis endometriosis ovarian cancer
immunodeficiency astrocytoma asthma hepatitis
1 disease from the University of Copenhagen DISEASES database for FPR2:Alzheimer's disease 10/11 Novoseek disease relationships for FPR2 gene (see all 11) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| inflammation |
53.6 |
18 |
17460114 (3), 12806051 (1), 12456400 (1), 14500740 (1) (see all 11) |
| alzheimers disease |
37.4 |
18 |
16219804 (1), 18785269 (1), 16339765 (1), 17237425 (1) (see all 11) |
| prion diseases |
28.7 |
4 |
17114475 (1), 11160182 (1), 18785269 (1) |
| neurodegenerative diseases |
27 |
3 |
15210823 (1), 15670157 (1), 20141570 (1) |
| rheumatoid arthritis |
19.9 |
2 |
19007292 (1), 17918787 (1) |
| bacterial infections |
17.9 |
3 |
15623572 (1), 16493063 (1), 16339765 (1) |
| cancer |
3.87 |
2 |
19491199 (1), 17938258 (1) |
| necrosis |
1.08 |
7 |
15147563 (1), 18458054 (1), 17418999 (1), 17938258 (1) (see all 6) |
| dermatitis |
0 |
1 |
17460114 (1) |
| tumors |
0 |
9 |
17938258 (2), 15829413 (1), 18458054 (1), 9547339 (1) (see all 6) |
Human Genome Epidemiology (HuGE) Navigator: FPR2 (3 documents)
Export disorders for FPR2 gene to outside databases
|
Publications
for FPR2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FPR2 gene, integrated from 9 sources (see all 201):
(articles sorted by number of sources associating them with FPR2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. (PubMed id 1612600)1, 2, 9 Bao L.... Gerard C. (1992)
- Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti- inflammatory receptors. (PubMed id 9151906)1, 2, 9 Takano T....Serhan C.N. (1997)
- A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family. (PubMed id 1373134)1, 2, 9 Murphy P.M....Francke U. (1992)
- Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor. (PubMed id 9054386)1, 3, 9 Maddox J.F....Serhan C.N. (1997)
- Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors. (PubMed id 7505609)1, 2, 9 Nomura H.... Matsushima K. (1993)
- Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release. (PubMed id 9547339)1, 2, 9 Gronert K.... Serhan C.N. (1998)
- Cloning of a cDNA encoding a receptor related to the formyl peptide receptor of human neutrophils. (PubMed id 1511907)1, 2, 9 Perez H.D.... Andrews W.H. (1992)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor. (PubMed id 1374236)1, 2 Ye R.D....Cochrane C.G. (1992)
|
External Searches for FPR2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FPR2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FPR2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FPR2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FPR2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FPR2 gene:
Search GeneIP for patents involving FPR2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for FPR2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FPR2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FPR2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FPR2 | | | OriGene Protein Over-expression Lysate for FPR2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FPR2 | | OriGene 3'-UTR Clone for FPR2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FPR2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FPR2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FPR2 | | OriGene Custom Protein Services for FPR2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FPR2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FPR2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FPR2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FPR2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FPR2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FPR2 |
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 | | | FPR2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FPR2 |
|  |  |  | | | | ThermoFisher Antibodies for FPR2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FPR2 |
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