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FPR1 Gene

protein-coding   GIFtS: 70
GCID: GC19M052249

Formyl Peptide Receptor 1

Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Formyl Peptide Receptor 11 2     FMLP2
FPR2 3     FMet-Leu-Phe Receptor2
FMLP Receptor2 3     N-Formyl Peptide Receptor3
N-Formylpeptide Chemoattractant Receptor2 3     

External Ids:    HGNC: 38261   Entrez Gene: 23572   Ensembl: ENSG000001710517   OMIM: 1365375   UniProtKB: P214623   

Export aliases for FPR1 gene to outside databases

Previous GC identifers: GC19M052879 GC19M052610 GC19M056924 GC19M056940 GC19M048579


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FPR1 Gene:
This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein
coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by
microorganisms and is important in host defense and inflammation.(provided by RefSeq, Jul 2010)

GeneCards Summary for FPR1 Gene:
FPR1 (formyl peptide receptor 1) is a protein-coding gene. Diseases associated with FPR1 include aggressive periodontitis, and prion disease. GO annotations related to this gene include N-formyl peptide receptor activity and receptor activity. An important paralog of this gene is LTB4R.

UniProtKB/Swiss-Prot: FPR1_HUMAN, P21462
Function: High affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic
factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a
G-protein that activates a phosphatidylinositol-calcium second messenger system

summary for FPR1 Gene:
The formyl peptide receptor family, FPR1, FPR2 and FPR3 (formerly FPR, FPRL1 and FPRL2 respectively) are Gi
protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes and found at lower
expression levels on endothelial cells, neurons, astrocytes and hepatocytes. Formyl peptide receptors are
involved in antibacterial host defence and inflammation. Activation of FPRs mediates induction of neutrophil
chemotaxis, production of reactive oxygen species (ROS) to clear damaged cells and stimulation of
degranulation of neutrophils. In addition, FPRs have a role in neutrophil transcriptional regulation and
cytokine production, and induce neutrophil apoptosis in a ROS-dependent manner. Recently, FPRs have been
implicated in the pathogenesis of amyloidosis, Alzheimer's disease, prion diseases and HIV. Ligand diversity
is a prominent and unusual feature of FPR family receptors, suggesting that these receptors may have more
complex functions than are currently appreciated. The human genes encoding FPR1, FPR2 and FPR3 are clustered
on chromosome 19q13.3-13.4.

Gene Wiki entry for FPR1 (Formyl peptide receptor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the FPR1 gene promoter:
         AP-1   ATF-2   FOXO4   FOXO1a   STAT3   c-Jun   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFPR1 promoter sequence
   Search Chromatin IP Primers for FPR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FPR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.41

FPR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FPR1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M052249:  view genomic region     (about GC identifiers)

Start:
52,248,425 bp from pter      End:
52,307,363 bp from pter
Size:
58,939 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FPR1_HUMAN, P21462 (See protein sequence)
Recommended Name: fMet-Leu-Phe receptor  
Size: 350 amino acids; 38446 Da
Secondary accessions: Q14939 Q7Z6A4 Q86U52 Q9NS48

Explore the universe of human proteins at neXtProt for FPR1: NX_P21462

Explore proteomics data for FPR1 at MOPED

Post-translational modifications: 

  • Phosphorylated; which is necessary for desensitization1
  • Glycosylation2 at Asn4, Asn10
  • Modification sites at PhosphoSitePlus

  • See FPR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001180235.1  NP_002020.1  

    ENSEMBL proteins: 
     ENSP00000471493   ENSP00000302707   ENSP00000472936   ENSP00000470750  
    Reactome Protein details: P21462

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FPR: GPCR / Class A : Formyl peptide receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: FPR1
    Formylpeptide receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000826 Formyl_pep_rcpt
     IPR027345 Formyl_pep_1_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P21462

    ProtoNet protein and cluster: P21462

    1 Blocks protein domain: IPB000826 Formyl-methionyl peptide receptor signature

    UniProtKB/Swiss-Prot: FPR1_HUMAN, P21462
    Similarity: Belongs to the G-protein coupled receptor 1 family


    FPR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FPR1_HUMAN, P21462
    Function: High affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic
    factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a
    G-protein that activates a phosphatidylinositol-calcium second messenger system

         Genatlas biochemistry entry for FPR1:
    formyl peptide (bacterial) receptor 1,mediating chemotaxis and inducing leukocyte
    activation,(formyl-Met-Leu-Phe),G protein coupled,secretin receptor superfamily

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS10857861
    GO:0004930G-protein coupled receptor activity ----
    GO:0004982N-formyl peptide receptor activity IDA12218158
    GO:0005515protein binding IPI--
    GO:0050786RAGE receptor binding IEA--
         
    FPR1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FPR1:
     Increased S DNA content  Increased cell number in G1, s 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fpr1):
     cellular  digestive/alimentary  endocrine/exocrine gland  hematopoietic system  immune system 
     mortality/aging 

    FPR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FPR1: Fpr1tm1Gao Fpr1/Fpr2Fpr1/tm1.1Jimw

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FPR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FPR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FPR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FPR1

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    hsa-mir-335-5p (MIRT018871)

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    SwitchGear 3'UTR luciferase reporter plasmidFPR1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FPR1_HUMAN, P21462: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endosome4
    cytoskeleton2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome TAS10823817
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    FPR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FPR1 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    Peptide ligand-binding receptors0.60
    Formyl peptide receptors bind formyl peptides and many other ligands0.00
    G alpha (i) signalling events0.44
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Ras signaling pathway
    Rap1 signaling pathway0.36
    5Staphylococcus aureus infection
    Staphylococcus aureus infection

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for FPR1
        Cytoskeleton remodeling RalA regulation pathway

    2 BioSystems Pathways for FPR1
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    2 Reactome Pathways for FPR1
        Formyl peptide receptors bind formyl peptides and many other ligands
    G alpha (i) signalling events


    3 Kegg Pathways  (Kegg details for FPR1):
        Rap1 signaling pathway
    Neuroactive ligand-receptor interaction
    Staphylococcus aureus infection


    FPR1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FPR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FPR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FPR1 (P214621, 3 ENSP000003027074) via UniProtKB, MINT, STRING, and/or I2D (see all 150)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADRBK1P250981, 3, ENSP000003122624EBI-2869495,EBI-3904795 I2D: score=1 STRING: ENSP00000312262
    ACTG1P632613, ENSP000003315144I2D: score=1 STRING: ENSP00000331514
    ANXA1P040833, ENSP000002574974I2D: score=1 STRING: ENSP00000257497
    GNAI2P048993, ENSP000003129994I2D: score=1 STRING: ENSP00000312999
    MAPK13O152641, ENSP000002112874EBI-2869495,EBI-2116951 STRING: ENSP00000211287
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity TAS10857861
    GO:0006928cellular component movement TAS10882119
    GO:0006935chemotaxis IEA--
    GO:0007165signal transduction TAS10820279
    GO:0007186G-protein coupled receptor signaling pathway TAS10823817

    FPR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for FPR1
      Browse compounds at ApexBio 

    Compounds for FPR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Boc-MLFFPR1 antagonist[67247-12-5]
    WRW4Selective FPR2 antagonist[878557-55-2]
    MMK 1Potent and selective FPR2 agonist[271246-66-3]
    WKYMVm FPR1, FPR2 and FPR3 receptor agonist [187986-17-0]
    WKYMVMSelective FPR2 and FPR3 receptor agonist[187986-11-4]

    1 HMDB Compound for FPR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for FPR1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Nedocromil-- 69049-73-6targetantagonist8384226 1326878 1329582

    Selected IUPHAR Ligands for FPR1 (FPR1) (see all 32)    About this table
    LigandTypeActionAffinityPubmed IDs
    fMet-Ile-Phe-Leu
    AgonistFull agonist10.52825171
    fMet-Leu-Phe
    AgonistFull agonist10.1 - 10.21262785 7387981
    [3H]fMet-Leu-Phe
    AgonistFull agonist7.6 - 9.36285921
    fMet-Met-Trp-Leu-Leu
    AgonistFull agonist97559498
    Met-Met-Trp-Leu-Leu
    AgonistFull agonist97559498
    WKYMVm
    AgonistFull agonist910586077
    fMet-Ile-Val-Ile-Leu
    AgonistFull agonist8.716025565
    fMet-Ile-Val-Thr-Leu-Phe
    AgonistFull agonist8.616025565
    T20(DP178)
    AgonistFull agonist8.310339497 10860818
    fMet-Met-Tyr-Ala-Leu-Phe
    AgonistFull agonist816025565

    Selected Novoseek inferred chemical compound relationships for FPR1 gene (see all 71)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fmlp 96.2 661 7619076 (8), 9850337 (8), 9178189 (7), 8756080 (7) (see all 99)
    n-formylmethionyl-leucylphenylalanine 91.2 62 8392932 (4), 1935939 (3), 2163872 (2), 7525325 (2) (see all 41)
    cyclosporin h 89.2 12 9727041 (3), 15494526 (1), 16549058 (1), 12370393 (1) (see all 8)
    fr 901459 81.7 3 10908115 (1), 12361388 (1)
    fnlpntl 73.1 2 8756080 (1), 11369647 (1)
    leukotriene b4 69 24 8241512 (2), 8756080 (2), 9845549 (1), 11135292 (1) (see all 13)
    superoxide 65.8 44 9178189 (3), 8136611 (3), 17692291 (3), 8225024 (2) (see all 29)
    lxa4 62.8 7 1910866 (3), 12410796 (2), 8376607 (1), 8527441 (1)
    calcium 62.4 117 1744114 (4), 9207244 (4), 9353293 (4), 1910866 (3) (see all 56)
    cytochalasin 60.6 1 8509449 (1)



    FPR1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FPR1 gene (2 alternative transcripts): 
    NM_001193306.1  NM_002029.3  

    Unigene Cluster for FPR1:

    Formyl peptide receptor 1
    Hs.753  [show with all ESTs]
    Unigene Representative Sequence: BM924794
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000595042 ENST00000304748(uc021uyn.1 uc002pxq.3) ENST00000600815
    ENST00000594900
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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      QuantiFast Probe-based Assays in human, mouse, rat FPR1

    Additional mRNA sequence: 

    AK314935.1 BC005315.1 BT007429.1 M37128.1 M60627.1 

    2 DOTS entries:

    DT.114544  DT.121504046 

    Selected AceView cDNA sequences (see all 86):

    CR617277 M60627 NM_002029 CB528963 BC005315 CB529350 AA035022 CD364449 
    CK904915 BI835348 BM719587 M60626 AA425767 M78084 BU741226 BX283670 
    BI760812 BU741238 AI744388 CD369350 AW051494 BI909107 M37128 BM682890 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FPR1 expression in normal human tissues (normalized intensities)      FPR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCAGGACT
    FPR1 Expression
    About this image


    FPR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical Veins
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    FPR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FPR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.753

    UniProtKB/Swiss-Prot: FPR1_HUMAN, P21462
    Tissue specificity: Neutrophils

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FPR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FPR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FPR1 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fpr11 , 5 formyl peptide receptor 11, 5 78.64(n)1
    78.34(a)1
      17 (10.63 cM)5
    142931  NM_013521.21  NP_038549.11 
     178764715 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    31(a)
    1 → many
    GL343604.1(277-1212)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-113g13.26
    si:ch73-113g13.2
    19(a)
    many ↔ many
    18(22493355-22494311) ENSDARG00000056506


    ENSEMBL Gene Tree for FPR1 (if available)
    TreeFam Gene Tree for FPR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FPR1 gene
    LTB4R2  GPR332  LTB4R22  FPR32  C5AR12  GPR322  GPR1522  FPR22  
    C5AR22  C3AR12  PTGDR22  GPR12  ENSG000002726582  CMKLR12  
    Selected SIMAP similar genes for FPR1 using alignment to 3 protein entries:     FPR1_HUMAN (see all proteins) (see all similar genes):
    C3AR1    FPR2    FPR3    FPRL2    GPR1    GPR32
    CMKLR1    CX3CR1    PTGDR2    CCR7    CXCR2    LTB4R2
    GPR18    GPR33    gpcr    CCR5    C5AR1    F2RL1

    FPR1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FPR1
    PGOHUM00000235418


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FPR1 (see all 246)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58284931,2
    C,F--52249072(+) AAGGCT/-TTTTT 2 -- ut31 trp33Minor allele frequency- -:0.50NA CSA 6
    rs2005501261,2
    C--52251038(+) AAAAA-/ACAATG 2 -- int10--------
    rs1115537131,2
    C,F--52254792(+) CACCAC/TGCCTG 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs356287531,2
    C--52256092(+) AAAAA-/A/AAA 
            
    TCCCC
    2 -- us2k11NA 2
    rs1464652391,2
    --52414156(+) TGCCTC/TGGTCT 1 -- ds50010--------
    rs18064431,2
    C,A--52414197(+) ACTACA/GCCCAG 2 -- int1 ds5001 ese30--------
    rs1855323861,2
    --52414216(+) TGTATA/TTTTAG 2 -- int1 ds50010--------
    rs18064441,2
    C,A--52414270(+) CCTGAC/TCCCTG 2 -- int1 ds5001 ese31Minor allele frequency- T:0.50NA 2
    rs18689421,2
    C,F,A--52414272(+) TGACCT/CCTGGT 2 -- int1 ds5001 ese35Minor allele frequency- C:0.30NA WA CSA 10
    rs46226241,2
    C,A--52414292(+) GCCTCG/AGCCTC 2 -- int1 ds5001 ese31Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for FPR1 (52248425 - 52307363 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for FPR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv458733CNV Gain19166990
    nsv524403CNV Gain19592680
    dgv143e55CNV Gain17911159
    nsv470151CNV Gain18288195
    esv638CNV CNV17122850
    dgv1109e1CNV Complex17122850
    dgv1110e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): FPR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FPR1
    DNA2.0 Custom Variant and Variant Library Synthesis for FPR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 136537    OMIM disorders: --

    Selected diseases for FPR1 (see all 30):    About MalaCards
    aggressive periodontitis    prion disease    shwachman-diamond syndrome    malignant glioma
    severe congenital neutropenia    amyloidosis    neutropenia    stomach cancer
    fainting    bronchitis    pertussis    periodontitis
    chronic myeloid leukemia    sepsis    alzheimer's disease    ulcerative colitis
    tuberculosis    endotheliitis    myelodysplastic syndromes    myeloid leukemia

    1 disease from the University of Copenhagen DISEASES database for FPR1:
    Aggressive periodontitis

    FPR1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for FPR1 gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    periodontitis juvenile 67.3 3 11559706 (1), 10534074 (1), 11607790 (1)
    leukemia basophilic 56.9 6 19706734 (1), 17082621 (1), 20195765 (1), 11238659 (1) (see all 5)
    malignant glioma 45.7 11 17611713 (2), 15258259 (1), 19233142 (1), 19037090 (1) (see all 5)
    glioblastoma 44.3 43 19037090 (5), 17575160 (4), 18433988 (4), 15928303 (4) (see all 12)
    inflammation 39.7 13 8573582 (1), 9845549 (1), 14500740 (1), 16118363 (1) (see all 11)
    bacterial infections 35.1 7 15187149 (1), 15623572 (1), 11238229 (1), 18060741 (1) (see all 5)
    glioma 20.9 28 15928303 (4), 16516855 (4), 17520823 (3), 19233142 (2) (see all 8)
    necrosis 6.39 6 15147563 (1), 11238229 (1), 12747235 (1), 7518434 (1) (see all 6)
    tuberculosis 4.97 1 12869034 (1)
    cancer 0.493 1 2007248 (1)

    Genetic Association Database (GAD): FPR1
    Human Genome Epidemiology (HuGE) Navigator: FPR1 (15 documents)

    Export disorders for FPR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for FPR1 gene, integrated from 10 sources (see all 386):
    (articles sorted by number of sources associating them with FPR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evaluation of human leukocyte N-formylpeptide receptor (FPR1) SNPs in aggressive periodontitis patients. (PubMed id 12595898)1, 3, 4, 9 Zhang Y....Hart T.C. (Genes Immun. 2003)
    2. Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA. (PubMed id 2161213)1, 2, 3 Boulay F.... Vignais P. (Biochem. Biophys. Res. Commun. 1990)
    3. Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. (PubMed id 1612600)1, 2, 9 Bao L.... Gerard C. (Genomics 1992)
    4. Cloning of the gene coding for a human receptor for formyl peptides. Characterization of a promoter region and evidence for polymorphic expression. (PubMed id 1445895)1, 2, 9 Perez H.D.... Andrews W.H. (Biochemistry 1992)
    5. The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors. (PubMed id 2176894)1, 2, 9 Boulay F.... Vignais P. (Biochemistry 1990)
    6. Formylpeptide receptor single nucleotide polymorphism 348T&gt;C and its relationship to polymorphonuclear leukocyte chemotaxis in aggressive periodontitis. (PubMed id 19722801)1, 4, 9 Maney P. and Walters J.D. (J. Periodontol. 2009)
    7. Differential phosphorylation paradigms dictate desensitization and internalization of the N-formyl peptide receptor. (PubMed id 10514456)1, 2, 9 Maestes D.C.... Prossnitz E.R. (J. Biol. Chem. 1999)
    8. Analysis of a missense variant of the human N-formyl peptide receptor that is associated with agonist-independent beta-arrestin association and indices of inflammation. (PubMed id 16953235)1, 4, 9 Bhattacharya M....Ferguson S.S. (Pharmacogenomics J. 2007)
    9. Functional polymorphisms of the FPR1 gene and aggressive periodontitis in Japanese. (PubMed id 17927965)1, 4, 9 Gunji T....Ishikawa I. (Biochem. Biophys. Res. Commun. 2007)
    10. Sequence and organization of the human N-formyl peptide receptor- encoding gene. (PubMed id 8224916)1, 2, 9 Murphy P.M.... Ahuja S.K. (Gene 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2357 HGNC: 3826 AceView: FPR1 Ensembl:ENSG00000171051 euGenes: HUgn2357
    ECgene: FPR1 Kegg: 2357 H-InvDB: FPR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FPR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FPR1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FPR1 gene:
    Search GeneIP for patents involving FPR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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