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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FPR1 Gene

protein-coding GIFtS: 68
GCID: GC19M052249

formyl peptide receptor 1

Explore 29 diseases affiliated with
FPR1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Formyl Peptide Receptor 1¹ ²		N-Formylpeptide Chemoattractant Receptor² ³
FPR¹ ² ³		FMet-Leu-Phe Receptor²
FMLP¹ ²		N-Formyl Peptide Receptor³
FMLP Receptor² ³

External Ids:	HGNC: 3826¹	Entrez Gene: 2357²	Ensembl: ENSG00000171051⁷	OMIM: 136537⁵	UniProtKB: P21462³

Export aliases for FPR1 gene to outside databases

Previous GC identifers: GC19M052879 GC19M052610 GC19M056924 GC19M056940 GC19M048579

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FPR1:

This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled

receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and

is important in host defense and inflammation.(provided by RefSeq, Jul 2010)

UniProtKB/Swiss-Prot: FPR1_HUMAN, P21462

Function: High affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors.

Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that

activates a phosphatidylinositol-calcium second messenger system

summary for FPR1:

The formyl peptide receptor family, FPR1, FPR2 and FPR3 (formerly FPR, FPRL1 and FPRL2 respectively) are Gi

protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes and found at lower

expression levels on endothelial cells, neurons, astrocytes and hepatocytes. Formyl peptide receptors are

involved in antibacterial host defence and inflammation. Activation of FPRs mediates induction of neutrophil

chemotaxis, production of reactive oxygen species (ROS) to clear damaged cells and stimulation of

degranulation of neutrophils. In addition, FPRs have a role in neutrophil transcriptional regulation and

cytokine production, and induce neutrophil apoptosis in a ROS-dependent manner. Recently, FPRs have been

implicated in the pathogenesis of amyloidosis, Alzheimer's disease, prion diseases and HIV. Ligand diversity

is a prominent and unusual feature of FPR family receptors, suggesting that these receptors may have more

complex functions than are currently appreciated. The human genes encoding FPR1, FPR2 and FPR3 are clustered

on chromosome 19q13.3-13.4.

Gene Wiki entry for FPR1 (Formyl peptide receptor 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FPR1 gene promoter:
AP-1 ATF-2 FOXO4 FOXO1a STAT3 c-Jun FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FPR1 promoter sequence

Search SABiosciences Chromatin IP Primers for FPR1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FPR1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13.41

FPR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FPR1 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M052249: view genomic region (about GC identifiers)

Start:	52,249,023 bp from pter	End:	52,255,150 bp from pter
Size:	6,128 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FPR1_HUMAN, P21462 (See protein sequence)

Recommended Name: fMet-Leu-Phe receptor

Size: 350 amino acids; 38446 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q14939 Q7Z6A4 Q86U52 Q9NS48

Explore the universe of human proteins at neXtProt for FPR1: NX_P21462

Post-translational modifications:

Phosphorylated; which is necessary for desensitization¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P21462

FPR1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001180235.1 NP_002020.1

ENSEMBL proteins:

ENSP00000302707

Reactome Protein details: P21462
Human Recombinant Protein Products:

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	Uscn Proteins for FPR1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005768	endosome	TAS	10823817
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

FPR1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for FPR1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FPR1 for domains About GeneDecksing

3 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR000826 Frt_met_rcpt

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P21462

ProtoNet protein and cluster: P21462

1 Blocks protein family: IPB000826 Formyl-methionyl peptide receptor signature

UniProtKB/Swiss-Prot: FPR1_HUMAN, P21462

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FPR1_HUMAN, P21462

Function: High affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors.

Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that

activates a phosphatidylinositol-calcium second messenger system

Genatlas biochemistry entry for FPR1:

formyl peptide (bacterial) receptor 1,mediating chemotaxis and inducing leukocyte activation,(formyl-Met-Leu-Phe),G

protein coupled,secretin receptor superfamily

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FPR1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	TAS	10857861
GO:0004982	N-formyl peptide receptor activity	IDA	12218158
GO:0005515	protein binding	IPI	--

FPR1 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for FPR1:

Increased S DNA content

Increased cell number in G1, s

Animal Models:
Mouse knock-out Fpr1^tm1Gao for FPR1
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Fpr1):

cellular

immune system

mortality/aging

FPR1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

Class A/1 (Rhodopsin-like receptors)	1.00	G alpha (i) signalling events	0.44
GPCR ligand binding	0.75	GPCRs, Class A Rhodopsin-like	0.41
Peptide ligand-binding receptors	0.61	Neuroactive ligand-receptor interaction	0.38

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

1.00

Peptide GPCRs

0.46

Cytoskeleton remodeling_RalB regulation pathway

Cytoskeleton remodeling RalA regulation pathway

0.23

Cytoskeleton remodeling_RalA regulation pathway

0.23

Formyl peptide receptors bind formyl peptides and many other ligands

Formyl peptide receptors bind formyl peptides and many other ligands

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for FPR1

	Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
	Cytoskeleton remodeling RalA regulation pathway

1 GeneGo (Thomson Reuters) Pathway for FPR1

Cytoskeleton remodeling RalA regulation pathway

2 BioSystems Pathways for FPR1

	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs

5/8 Reactome Pathways for FPR1 (see all 8)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Formyl peptide receptors bind formyl peptides and many other ligands
	Signal Transduction
	Signaling by GPCR

2 Kegg Pathways (Kegg details for FPR1):

	Neuroactive ligand-receptor interaction
	Staphylococcus aureus infection

FPR1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FPR1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/150 Interacting proteins for FPR1 (P21462^{1, 3} ENSP00000302707⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 150)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADRBK1	P25098¹^,³, ENSP00000312262⁴	EBI-2869495,EBI-3904795 I2D: score=1 STRING: ENSP00000312262
ACTG1	P63261³, ENSP00000331514⁴	I2D: score=1 STRING: ENSP00000331514
ANXA1	P04083³, ENSP00000257497⁴	I2D: score=1 STRING: ENSP00000257497
GNAI2	P04899³, ENSP00000312999⁴	I2D: score=1 STRING: ENSP00000312999
MAPK13	O15264¹, ENSP00000211287⁴	EBI-2869495,EBI-2116951 STRING: ENSP00000211287

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	TAS	10857861
GO:0006928	cellular component movement	TAS	10882119
GO:0006935	chemotaxis	IEA	--
GO:0007165	signal transduction	TAS	10820279
GO:0007186	G-protein coupled receptor signaling pathway	TAS	10823817

FPR1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FPR1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for FPR1

Compounds for FPR1 available from Tocris Bioscience About this table

Compound	Action	CAS #
WKYMVm	FPR1, FPR2 and FPR3 receptor agonist	[187986-17-0]
N-Formyl-Met-Leu-Phe	Endogenous FPR1 agonist	[59880-97-6]

1 HMDB Compound for FPR1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

1 DrugBank Compound for FPR1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Nedocromil	--	69049-73-6	target	antagonist	8384226 1326878 1329582

10/71 Novoseek chemical compound relationships for FPR1 gene (see all 71) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fmlp	96.2	661	7619076 (8), 9850337 (8), 9178189 (7), 8756080 (7) (see all 99)
n-formylmethionyl-leucylphenylalanine	91.2	62	8392932 (4), 1935939 (3), 2163872 (2), 7525325 (2) (see all 41)
cyclosporin h	89.2	12	9727041 (3), 15494526 (1), 16549058 (1), 12370393 (1) (see all 8)
fr 901459	81.7	3	10908115 (1), 12361388 (1)
fnlpntl	73.1	2	8756080 (1), 11369647 (1)
leukotriene b4	69	24	8241512 (2), 8756080 (2), 9845549 (1), 11135292 (1) (see all 13)
superoxide	65.8	44	9178189 (3), 8136611 (3), 17692291 (3), 8225024 (2) (see all 29)
lxa4	62.8	7	1910866 (3), 12410796 (2), 8376607 (1), 8527441 (1)
calcium	62.4	117	1744114 (4), 9207244 (4), 9353293 (4), 1910866 (3) (see all 56)
cytochalasin	60.6	1	8509449 (1)

Search CenterWatch for drugs/clinical trials and news about FPR1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FPR1 gene (2 alternative transcripts):

NM_001193306.1 NM_002029.3

Unigene Cluster for FPR1:

Formyl peptide receptor 1

Hs.753 [show with all ESTs]

Unigene Representative Sequence: BM924794

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000304748(uc021uyn.1 uc002pxq.3)

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Additional cDNA sequence:

AK314935.1 BC005315.1 BT007429.1 M37128.1 M60627.1

2 DOTS entries:

DT.114544 DT.121504046

24/86 AceView cDNA sequences (see all 86):

CR617277 NM_002029 M60627 BX283670 BG540422 CK904915 M60626 CB528963

BI760812 BT007429 BC005315 BM719587 BM726960 BU741226 CB529350 BG483022

BQ016000 AA203362 BM682890 AI744388 AW237155 CB993626 M37128 CD369210

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FPR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCCAGGACT

About this image

FPR1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Umbilical Cord

Umbilical Veins

Umbilical Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FPR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FPR1

SOURCE GeneReport for Unigene cluster: Hs.753

UniProtKB/Swiss-Prot: FPR1_HUMAN, P21462

Tissue specificity: Neutrophils

SABiosciences Expression via Pathway-Focused PCR Arrays including FPR1:

G Protein Coupled Receptors 384HT in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Chemokines & Receptors in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FPR1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FPR1 gene from 2/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	30(a) 30(a) (see all 3)	possible ortholog 1 ↔ many (see all 3)	GL343604.1(277-1212) LGf(1022326-1023342)
zebrafish (Danio rerio)	Actinopterygii	CABZ01029333.1⁶ CABZ01029334.1⁶ (see all 5)	--	34(a) 33(a) (see all 5)	many ↔ many many ↔ many (see all 5)	19(11141054-11142081) 19(11148973-11150089)

ENSEMBL Gene Tree for FPR1 (if available)
TreeFam Gene Tree for FPR1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FPR1 gene

LTB4R² LTB4R2² FPR3² C5AR1² GPR32² GPR152² FPR2² C5AR2²

C3AR1² PTGDR2² GPR1² CMKLR1²

18/24 SIMAP similar genes for FPR1 using alignment to 3 protein entries: FPR1_HUMAN (see all proteins) (see all similar genes):

FPR2 FPR3 FPRL2 GPR32 PTGDR2 CMKLR1

GPR1 GPR33 gpcr C5AR1 AGTR1 CXCR1

CXCR2 IL8RB SSTR1 CCR9 SSTR4 GPR77

FPR1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for FPR1
PGOHUM00000235418

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs867341^1,2	C,F,H,	--	48579920(-)	`CAGGCA/GTTTCC`	2	--	ut3¹ ese³		15		MN NS EA NA CSA	1983
rs113978889^1,2	C,	--	48581689(+)	`CAAAG-/ATTCA TGAATACATGTA`	2	--	int¹		1		CSA	2
rs75625307^1,2	C	--	48582049(-)	`ATTTTG/TAAAGT`	2	--	int¹		3		NA	8
rs10469301^1,2	H,	--	48582875(+)	`ATAAGA/GTATCA`	2	--	int¹		4		NS EA	392
rs112591851^1,2	C,	--	48583184(+)	`AATCAC/TTTGAA`	2	--	int¹		1		NA	2
rs7255118^1,2	H	--	48583330(+)	`TAAGGT/ACATGA`	2	--	int¹		4		NS EA	396
rs34447090^1,2	C,F,	--	48583511(+)	`TCTCTG/ACGGTT`	2	--	int¹		4		NA	126
rs74708043^1,2		--	48584534(+)	`AATGAA/GCTTTG`	2	--	int¹		0	--	--	--	--
rs7247639^1,2	C,F,A,H,	--	48585351(+)	`CTTCTC/GTCTCC`	2	--	int¹ trp³		5		NS EA WA	520
rs111553713^1,2		--	48585591(+)	`CACCAC/TGCCTG`	2	--	int¹		1		CSA	2

HapMap Linkage Disequilibrium report for FPR1 (52249023 - 52255150 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for FPR1
3 CNVs: 8875 34482 4085
Human Gene Mutation Database (HGMD): FPR1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FPR1 for disorders           About GeneDecksing

OMIM gene information: 136537    OMIM disorders: --

20/29 diseases for FPR1 (see all 29):    About MalaCards

prion disease amyloidosis shwachman-diamond syndrome alzheimer's disease

severe congenital neutropenia malignant glioma neutropenia myeloid leukemia

aggressive periodontitis chronic myeloid leukemia neuronitis ulcerative colitis

periodontitis cystic fibrosis fainting stomach cancer

diabetes mellitus bronchitis myelodysplastic syndrome down syndrome

2 diseases from the University of Copenhagen DISEASES database for FPR1:

Aggressive periodontitis Down syndrome

10/17 Novoseek disease relationships for FPR1 gene (see all 17) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
periodontitis juvenile	67.3	3	11559706 (1), 10534074 (1), 11607790 (1)
leukemia basophilic	56.9	6	19706734 (1), 17082621 (1), 20195765 (1), 11238659 (1) (see all 5)
malignant glioma	45.7	11	17611713 (2), 15258259 (1), 19233142 (1), 19037090 (1) (see all 5)
glioblastoma	44.3	43	19037090 (5), 17575160 (4), 18433988 (4), 15928303 (4) (see all 12)
inflammation	39.7	13	8573582 (1), 9845549 (1), 14500740 (1), 16118363 (1) (see all 11)
bacterial infections	35.1	7	15187149 (1), 15623572 (1), 11238229 (1), 18060741 (1) (see all 5)
glioma	20.9	28	15928303 (4), 16516855 (4), 17520823 (3), 19233142 (2) (see all 8)
necrosis	6.39	6	15147563 (1), 11238229 (1), 12747235 (1), 7518434 (1) (see all 6)
tuberculosis	4.97	1	12869034 (1)
cancer	0.493	1	2007248 (1)

Genetic Association Database (GAD): FPR1
Human Genome Epidemiology (HuGE) Navigator: FPR1 (15 documents)

Export disorders for FPR1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FPR1 gene, integrated from 9 sources (see all 379):
(articles sorted by number of sources associating them with FPR1)

Utopia: connect your pdf to the dynamic
world of online information

Evaluation of human leukocyte N-formylpeptide recepto r (FPR1) SNPs in aggressive periodontitis patients. (PubMed id 12595898)^{1, 3, 4, 9} Zhang Y....Hart T.C. (2003)
Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA. (PubMed id 2161213)^{1, 2, 3} Boulay F.... Vignais P. (1990)
Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. (PubMed id 1612600)^{1, 2, 9} Bao L.... Gerard C. (1992)
Cloning of the gene coding for a human receptor for formyl peptides. Characterization of a promoter region and evidence for polymorphic expression. (PubMed id 1445895)^{1, 2, 9} Perez H.D.... Andrews W.H. (1992)
The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors. (PubMed id 2176894)^{1, 2, 9} Boulay F.... Vignais P. (1990)
Differential phosphorylation paradigms dictate desensitization and internalization of the N-formyl peptide receptor. (PubMed id 10514456)^{1, 2, 9} Maestes D.C.... Prossnitz E.R. (1999)
Sequence and organization of the human N-formyl peptide receptor- encoding gene. (PubMed id 8224916)^{1, 2, 9} Murphy P.M.... Ahuja S.K. (1993)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{1, 2} Grimwood J.... Lucas S.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Functional expression of the human formyl peptide receptor in Xenopus oocytes requires a complementary human factor. (PubMed id 1712023)^{1, 2} Murphy P.M. and McDermott D. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2357	HGNC: 3826	AceView: FPR1	Ensembl:ENSG00000171051	euGenes: HUgn2357
ECgene: FPR1	Kegg: 2357	H-InvDB: FPR1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FPR1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FPR1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for FPR1 gene:
Search GeneIP for patents involving FPR1

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formyl peptide receptor 1

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