Aliases for FPR1 Gene
External Ids for FPR1 Gene
This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]
GeneCards Summary for FPR1 Gene
FPR1 (Formyl Peptide Receptor 1) is a Protein Coding gene. Diseases associated with FPR1 include aggressive periodontitis and malignant glioma. Among its related pathways are Ras signaling pathway and Signaling by GPCR. GO annotations related to this gene include receptor activity and N-formyl peptide receptor activity. An important paralog of this gene is FPR2.
UniProtKB/Swiss-Prot for FPR1 Gene
High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456).
The formyl peptide receptor family, FPR1, FPR2 and FPR3 (formerly FPR, FPRL1 and FPRL2 respectively) are Gi protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes and found at lower expression levels on endothelial cells, neurons, astrocytes and hepatocytes. Formyl peptide receptors are involved in antibacterial host defence and inflammation. Activation of FPRs mediates induction of neutrophil chemotaxis, production of reactive oxygen species (ROS) to clear damaged cells and stimulation of degranulation of neutrophils. In addition, FPRs have a role in neutrophil transcriptional regulation and cytokine production, and induce neutrophil apoptosis in a ROS-dependent manner. Recently, FPRs have been implicated in the pathogenesis of amyloidosis, Alzheimers disease, prion diseases and HIV. Ligand diversity is a prominent and unusual feature of FPR family receptors, suggesting that these receptors may have more complex functions than are currently appreciated. The human genes encoding FPR1, FPR2 and FPR3 are clustered on chromosome 19q13.3-13.4.