FPGT-TNNI3K Gene
protein-coding GIFtS: 30
GCID: GC01P074671
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FPGT-TNNI3K readthrough
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Aliases
for FPGT-TNNI3K gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| FPGT-TNNI3K Readthrough1 2 | | Cardiac Ankyrin Repeat Kinase3 | | FPGT-TNNI3K Fusion Protein2 | | Cardiac Troponin I-Interacting Kinase3 | | CARK3 | | TNNI3-Interacting Kinase3 | | EC 2.7.11.13 | | |
Export aliases for FPGT-TNNI3K gene to outside databasesPrevious GC identifers: GC01U903137 GC01P074665 GC01P074667 |
Summaries
for FPGT-TNNI3K gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FPGT-TNNI3K:
This locus represents naturally occurring read-through transcription from the neighboring fucose-1-phosphateguanylyltransferase (FPGT) and TNNI3 interacting kinase (TNNI3K) genes. Alternative splicing results in multipletranscript variants that are composed of in-frame exons from each individual gene. (provided by RefSeq, Dec 2010)
UniProtKB/Swiss-Prot: TNI3K_HUMAN, Q59H18Function: May play a role in cardiac physiology
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Genomic Views
for FPGT-TNNI3K gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for FPGT-TNNI3K
Other transcription factors
Search SABiosciences Chromatin IP Primers for FPGT-TNNI3K
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FPGT-TNNI3K |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p31.1 Ensembl cytogenetic band: 1p31.1 HGNC cytogenetic band: 1p31.3FPGT-TNNI3K Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P074671: view genomic region
(about GC identifiers)
Start:
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74,663,937 bp from pter |
End:
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75,010,112 bp from pter |
Size:
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346,176 bases |
Orientation:
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plus strand |
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Proteins
for FPGT-TNNI3K gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TNI3K_HUMAN, Q59H18 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase TNNI3K Size: 835 amino acids; 92851 Da
Cofactor: Magnesium
Subunit: Interacts with TNNI3, ACTC, ACTA1, MYBPC3, AIP, BABP3 and HADHB
Subcellular location: Nucleus. Cytoplasm. Note=Expressed at lower levels in the cytoplasm
Sequence caution: Sequence=BAD92178.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=CAE45949.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q17RN0 Q49AR1 Q6MZS9 Q9Y2V6Alternative splicing: 4 isoforms: Q59H18-2 Q59H18-1 Q59H18-3 Q59H18-4 (Based on a naturally occurring readthrough transcript which produces a FPGT-TNNI3K fusion protein)Explore the universe of human proteins at neXtProt for FPGT-TNNI3K: NX_Q59H18
Post-translational modifications:
Autophosphorylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q59H18
FPGT-TNNI3K Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001106279.1 NP_001186256.1
ENSEMBL proteins: ENSP00000359930 ENSP00000322251 ENSP00000431465 ENSP00000434975 ENSP00000433550 ENSP00000359928
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
FPGT-TNNI3K for ontologies About GeneDecksing
FPGT-TNNI3K Antibody Products:
Assay Products for FPGT-TNNI3K: |
Protein
Domains /
Families
for FPGT-TNNI3K gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FPGT-TNNI3K for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q59H18ProtoNet protein and cluster: Q59H18 UniProtKB/Swiss-Prot: TNI3K_HUMAN, Q59H18Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinasesubfamilySimilarity: Contains 10 ANK repeatsSimilarity: Contains 1 protein kinase domain |
Function
for FPGT-TNNI3K gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TNI3K_HUMAN, Q59H18Function: May play a role in cardiac physiologyCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Number (IUBMB): EC 2.7.11.11
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FPGT-TNNI3K |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
FPGT-TNNI3K for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for FPGT-TNNI3K:
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Pathways & Interactions
for FPGT-TNNI3K gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FPGT-TNNI3K
STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)
5/16 Interacting proteins for FPGT-TNNI3K (Q59H181, 3 ENSP000003599284) via UniProtKB, MINT, STRING, and/or I2D (see all 16)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0006468 | protein phosphorylation |
-- | -- |
FPGT-TNNI3K for ontologies About GeneDecksing
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Drugs & Compounds
for FPGT-TNNI3K gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FPGT-TNNI3K
Search CenterWatch for drugs/clinical trials and news about FPGT-TNNI3K / TNI3K 
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Transcripts
for FPGT-TNNI3K gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FPGT-TNNI3K gene (2 alternative transcripts): NM_001112808.2 NM_001199327.1 11 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000533006 ENST00000370893 ENST00000326637(uc001dgf.2) ENST00000530184
ENST00000497284 ENST00000526236 ENST00000534020 ENST00000525480 ENST00000370889
ENST00000465473 ENST00000370891(uc001dge.2)
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for FPGT-TNNI3K (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | ^ | 6a | · | 6b | · | 6c |
|---|
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| SP1: | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | - | | | | | | - | | - | | - | | - | | - | | | | | | |
| SP3: | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FPGT-TNNI3K
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Expression
for FPGT-TNNI3K gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See FPGT-TNNI3K Protein Expression from SPIRE MOPED and PaxDBUniProtKB/Swiss-Prot: TNI3K_HUMAN, Q59H18Tissue specificity: Highly expressed in both adult and fetal heart
SABiosciences Custom PCR Arrays for FPGT-TNNI3K
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FPGT-TNNI3K | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FPGT-TNNI3K | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FPGT-TNNI3K | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FPGT-TNNI3K |
Orthologs
for FPGT-TNNI3K gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for FPGT-TNNI3K gene from 6/16 species (see all 16) About this table
ENSEMBL Gene Tree for FPGT-TNNI3K (if available)
TreeFam Gene Tree for FPGT-TNNI3K (if available) |
Paralogs
for FPGT-TNNI3K gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FPGT-TNNI3K gene
- MAP3K112 MAP3K122 KIAA18042 RAF12 KSR22 KSR12 BRAF2 MOS2
- MAP3K102 MAP3K92 ARAF2 MAP3K72 MAP3K7CL2 ZAK2 MAP3K132 ILK2
2 SIMAP similar genes for FPGT-TNNI3K using alignment to 1 protein entry: E9PKE1_HUMAN:TNNI3K FPGT
FPGT-TNNI3K for paralogs About GeneDecksing
|
Genomic Variants
for FPGT-TNNI3K gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FPGT-TNNI3K (74663937 - 74913937 bp, first 250kb of FPGT-TNNI3K)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FPGT-TNNI3K: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FPGT-TNNI3K |
|
Disorders
/ Diseases
for FPGT-TNNI3K gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FPGT-TNNI3K gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FPGT-TNNI3K gene integrated from 9 sources:
(articles sorted by number of sources associating them with FPGT-TNNI3K) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1 Speliotes E.K....Loos R.J. (2010)
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (2010)
- Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I. (PubMed id 12721663)2 Zhao Y.... Ding J.-F. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for FPGT-TNNI3K gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing FPGT-TNNI3K gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FPGT-TNNI3K gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FPGT-TNNI3K gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| SeattleSNPs | http://pga.gs.washington.edu/data/tnni3k/ |
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About This Section
| Patent Information for FPGT-TNNI3K gene:
Search GeneIP for patents involving FPGT-TNNI3K
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FPGT-TNNI3K gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FPGT-TNNI3K | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FPGT-TNNI3K | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FPGT-TNNI3K | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FPGT-TNNI3K | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FPGT-TNNI3K | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FPGT-TNNI3K |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FPGT-TNNI3K |
|  |  |  | | | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FPGT-TNNI3K |
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