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FPGT-TNNI3K Gene

protein-coding   GIFtS: 24
GCID: GC01P074674

FPGT-TNNI3K Readthrough

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FPGT-TNNI3K Readthrough1 2
FPGT-TNNI3K Fusion Protein2

External Ids:    HGNC: 429521   Entrez Gene: 1005268352   Ensembl: ENSG000002590307   UniProtKB: A6NHC74   UniProtKB: E9PKE14   
UniProtKB: V9GXZ44   

Export aliases for FPGT-TNNI3K gene to outside databases

Previous GC identifers: GC01U903137 GC01P074665 GC01P074667 GC01P074671


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FPGT-TNNI3K Gene:
This locus represents naturally occurring read-through transcription from the neighboring fucose-1-phosphate
guanylyltransferase (FPGT) and TNNI3 interacting kinase (TNNI3K) genes. Alternative splicing results in multiple
transcript variants that are composed of in-frame exons from each individual gene. (provided by RefSeq, Dec 2010)

GeneCards Summary for FPGT-TNNI3K Gene:
FPGT-TNNI3K (FPGT-TNNI3K readthrough) is a protein-coding gene. An important paralog of this gene is MAP3K12.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for FPGT-TNNI3K
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FPGT-TNNI3K


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.3

FPGT-TNNI3K Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FPGT-TNNI3K gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P074674:  view genomic region     (about GC identifiers)

Start:
74,663,896 bp from pter      End:
75,010,116 bp from pter
Size:
346,221 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/TrEMBL: A6NHC7 (See protein sequence)
Recommended Name: Protein FPGT-TNNI3K  
Size: 151 amino acids; 17293 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: E9PKE1 (See protein sequence)

Recommended Name: Protein FPGT-TNNI3K  
Size: 162 amino acids; 18040 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: V9GXZ4 (See protein sequence)

Recommended Name: Protein FPGT-TNNI3K  
Size: 949 amino acids; 105589 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

REFSEQ proteins (2 alternative transcripts): 
NP_001106279.2  NP_001186256.2  

ENSEMBL proteins: 
 ENSP00000450895   ENSP00000359936   ENSP00000359932   ENSP00000433587   ENSP00000359930  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Selected InterPro protein domains (see all 6):
 IPR017441 Protein_kinase_ATP_BS
 IPR011009 Kinase-like_dom
 IPR000719 Prot_kinase_dom
 IPR002110 Ankyrin_rpt
 IPR001245 Ser-Thr/Tyr_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry A6NHC7
Graphical View of Domain Structure for InterPro Entry E9PKE1
Graphical View of Domain Structure for InterPro Entry V9GXZ4

ProtoNet protein and cluster: A6NHC7

UniProtKB/TrEMBL: V9GXZ4
Similarity: Contains 10 ANK repeats


Find genes that share domains with FPGT-TNNI3K           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004672protein kinase activity ----
GO:0004713protein tyrosine kinase activity ----
GO:0005515protein binding ----
GO:0005524ATP binding ----
GO:0016772transferase activity, transferring phosphorus-containing groups ----
     
Find genes that share ontologies with FPGT-TNNI3K           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for FPGT-TNNI3K:
 Decreased viability of wild-ty  Increased S DNA content, incre 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for FPGT-TNNI3K

miRNA
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hsa-mir-335-5p (MIRT016954)

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hsa-miR-223 hsa-miR-626
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

    Search GeneGlobe Interaction Network for FPGT-TNNI3K

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006468protein phosphorylation ----

Find genes that share ontologies with FPGT-TNNI3K           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for FPGT-TNNI3K



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for FPGT-TNNI3K gene (2 alternative transcripts): 
NM_001112808.2  NM_001199327.1  

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000557284 ENST00000370899(uc001dgd.3) ENST00000370895(uc001dgc.2)
ENST00000534632 ENST00000533006 ENST00000370893
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hsa-miR-223 hsa-miR-626
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FPGT-TNNI3K expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
FPGT-TNNI3K Expression
About this image

FPGT-TNNI3K Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for FPGT-TNNI3K gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves TNNI3K6
Gallus gallus TNNI3 interacting kinase (TNNI3K), m...
90(a)
1 → many
8(28465964-28515307)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
91(a)
1 → many
GL343194.1(2418276-2645629)
zebrafish
(Danio rerio)
Actinopterygii tnni3k6
TNNI3 interacting kinase
84(a)
1 → many
8(18477819-18499717) ENSDARG00000086933
worm
(Caenorhabditis elegans)
Secernentea C24A1.36
Protein C24A1.3, isoform a
42(a)
1 → many
III(692509-696456) WBGene00016030
        Species with no ortholog for FPGT-TNNI3K

ENSEMBL Gene Tree for FPGT-TNNI3K (if available)
TreeFam Gene Tree for FPGT-TNNI3K (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for FPGT-TNNI3K gene
MAP3K122  MAP3K112  KIAA18042  RAF12  KSR22  KSR12  MOS2  BRAF2  
MAP3K92  MAP3K102  ARAF2  MAP3K72  TNNI3K2  ZAK2  MAP3K132  ILK2  
Selected SIMAP similar genes for FPGT-TNNI3K using alignment to 3 protein entries:     A6NHC7_HUMAN (see all proteins) (see all similar genes):
TNNI3K    FPGT    OSBPL1A    BRAF    MAP3K10    PPP1R12A
RPS6KA1    RPS6KA2    ANKRD54    FGFR1    GABPB1    ANK3
ANK2    ANKRD44    ANKS3    ZAK    ANKRD6    ANKRD65

Find genes that share paralogs with FPGT-TNNI3K           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FPGT-TNNI3K (see all 432)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1126722891,2
C,F--74674666(+) AGAGTT/CACAAT 2 -- int12Minor allele frequency- C:0.03NA 122
rs1881595561,2
--74674669(+) GTTACA/GATGGA 2 -- int10--------
rs175920801,2
C,F,H--74674694(+) CATTAG/ATAGCT 2 -- int119Minor allele frequency- A:0.08NA NS EA WA 2202
rs1387783781,2
--74674723(+) TTCAGA/GTGCTC 2 -- int10--------
rs1493860351,2
--74674821(+) TAATAA/GCAACC 2 -- int10--------
rs1810034591,2
--74674958(+) TTGTCA/GTATTT 2 -- int10--------
rs112104331,2
C,F,A,H--74675035(+) TGTATA/GTACAG 2 -- int18Minor allele frequency- G:0.28NA CSA WA EA 369
rs170949451,2
C,F,H--74675208(+) TGACAA/GCTTTG 2 -- int18Minor allele frequency- G:0.02NA NS EA WA 680
rs127544651,2
C,F,H--74675210(+) ACAACT/CTTGGG 2 -- int111Minor allele frequency- C:0.02NA NS EA 688
rs124108791,2
C,F,A,H--74675245(+) AATAAT/CAAAAG 2 -- int111Minor allele frequency- C:0.26NA CSA WA EA 512

HapMap Linkage Disequilibrium report for FPGT-TNNI3K (74663896 - 74913896 bp, first 250kb of FPGT-TNNI3K)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for FPGT-TNNI3K (see all 29):    About this table    
Variant IDTypeSubtypePubMed ID
esv2749963CNV Deletion23290073
esv2549117CNV Deletion19546169
esv4202CNV Deletion18987735
esv1000471CNV Deletion20482838
esv2749941CNV Deletion23290073
esv1932816CNV Deletion18987734
esv1327381CNV Deletion17803354
esv2350476CNV Deletion18987734
esv2660597CNV Deletion23128226
esv2749952CNV Deletion23290073

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FPGT-TNNI3K gene integrated from 10 sources:
(articles sorted by number of sources associating them with FPGT-TNNI3K)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PubMed id 23563607)1 Berndt S.I....Ingelsson E. (Nat. Genet. 2013)
  2. Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. (PubMed id 23449627)1 Cousminer D.L....WidAcn E. (Hum. Mol. Genet. 2013)
  3. Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course. (PubMed id 23669352)1 Graff M....Berndt S.I. (Hum. Mol. Genet. 2013)
  4. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1 Speliotes E.K....Loos R.J. (Nat. Genet. 2010)
  5. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (PLoS ONE 2010)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 100526835 HGNC: 42952 Ensembl:ENSG00000259030 euGenes: HUgn100526835 ECgene: FPGT-TNNI3K
H-InvDB: FPGT-TNNI3K

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for FPGT-TNNI3K gene:
Search GeneIP for patents involving FPGT-TNNI3K

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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