Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FPGT-TNNI3K Gene

Aliases for FPGT-TNNI3K Gene

  • FPGT-TNNI3K Readthrough 2 3 5

External Ids for FPGT-TNNI3K Gene

Previous GeneCards Identifiers for FPGT-TNNI3K Gene

  • GC01U903137
  • GC01P074665
  • GC01P074667
  • GC01P074671
  • GC01P074674

Summaries for FPGT-TNNI3K Gene

Entrez Gene Summary for FPGT-TNNI3K Gene

  • This locus represents naturally occurring read-through transcription from the neighboring fucose-1-phosphate guanylyltransferase (FPGT) and TNNI3 interacting kinase (TNNI3K) genes. Alternative splicing results in multiple transcript variants that are composed of in-frame exons from each individual gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for FPGT-TNNI3K Gene

FPGT-TNNI3K (FPGT-TNNI3K Readthrough) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TNNI3K.

Additional gene information for FPGT-TNNI3K Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FPGT-TNNI3K Gene

Genomics for FPGT-TNNI3K Gene

Regulatory Elements for FPGT-TNNI3K Gene

Enhancers for FPGT-TNNI3K Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H074197 1 ENCODE 0.7 +0.1 126 2 HDGF ATF1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 GLIS2 ELK1 LRRIQ3 FPGT FPGT-TNNI3K TNNI3K
GH01H074199 0.6 ENCODE 0.7 +1.5 1500 0 HDAC1 BHLHE40 IKZF1 MAX CEBPG MNT FOXJ2 SPI1 FPGT FPGT-TNNI3K TNNI3K
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FPGT-TNNI3K on UCSC Golden Path with GeneCards custom track

Promoters for FPGT-TNNI3K Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000008557 288 1801 HDGF ATF1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ELK1 ZNF143

Genomic Location for FPGT-TNNI3K Gene

Chromosome:
1
Start:
74,198,212 bp from pter
End:
74,544,432 bp from pter
Size:
346,221 bases
Orientation:
Plus strand

Genomic View for FPGT-TNNI3K Gene

Genes around FPGT-TNNI3K on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FPGT-TNNI3K Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FPGT-TNNI3K Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FPGT-TNNI3K Gene

Proteins for FPGT-TNNI3K Gene

  • Protein details for FPGT-TNNI3K Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A6NHC7
    Recommended name:
    FPGT-TNNI3K readthrough
    Protein Accession:
    A6NHC7

    Protein attributes for FPGT-TNNI3K Gene

    Size:
    151 amino acids
    Molecular mass:
    17293 Da
    Quaternary structure:
    No Data Available
  • Protein details for FPGT-TNNI3K Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    E9PKE1
    Recommended name:
    FPGT-TNNI3K readthrough
    Protein Accession:
    E9PKE1

    Protein attributes for FPGT-TNNI3K Gene

    Size:
    162 amino acids
    Molecular mass:
    18040 Da
    Quaternary structure:
    No Data Available
  • Protein details for FPGT-TNNI3K Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    V9GXZ4
    Recommended name:
    FPGT-TNNI3K readthrough
    Protein Accession:
    V9GXZ4

    Protein attributes for FPGT-TNNI3K Gene

    Size:
    949 amino acids
    Molecular mass:
    105589 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FPGT-TNNI3K Gene

Post-translational modifications for FPGT-TNNI3K Gene

No Post-translational modifications

Other Protein References for FPGT-TNNI3K Gene

No data available for DME Specific Peptides for FPGT-TNNI3K Gene

Domains & Families for FPGT-TNNI3K Gene

Gene Families for FPGT-TNNI3K Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FPGT-TNNI3K: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for FPGT-TNNI3K Gene

Function for FPGT-TNNI3K Gene

Phenotypes From GWAS Catalog for FPGT-TNNI3K Gene

Gene Ontology (GO) - Molecular Function for FPGT-TNNI3K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IBA --
GO:0004871 signal transducer activity IBA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with FPGT-TNNI3K: view

Phenotypes for FPGT-TNNI3K Gene

genes like me logo Genes that share phenotypes with FPGT-TNNI3K: view

Animal Model Products

CRISPR Products

miRNA for FPGT-TNNI3K Gene

miRTarBase miRNAs that target FPGT-TNNI3K

Clone Products

  • Applied Biological Materials Clones for FPGT-TNNI3K
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FPGT-TNNI3K Gene

Localization for FPGT-TNNI3K Gene

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FPGT-TNNI3K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with FPGT-TNNI3K: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for FPGT-TNNI3K Gene

Pathways & Interactions for FPGT-TNNI3K Gene

SuperPathways for FPGT-TNNI3K Gene

No Data Available

Interacting Proteins for FPGT-TNNI3K Gene

Gene Ontology (GO) - Biological Process for FPGT-TNNI3K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IBA --
GO:0035556 intracellular signal transduction IBA --
GO:1903779 regulation of cardiac conduction IBA --
genes like me logo Genes that share ontologies with FPGT-TNNI3K: view

No data available for Pathways by source and SIGNOR curated interactions for FPGT-TNNI3K Gene

Drugs & Compounds for FPGT-TNNI3K Gene

No Compound Related Data Available

Transcripts for FPGT-TNNI3K Gene

mRNA/cDNA for FPGT-TNNI3K Gene

(2) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for FPGT-TNNI3K
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FPGT-TNNI3K Gene

No ASD Table

Relevant External Links for FPGT-TNNI3K Gene

GeneLoc Exon Structure for
FPGT-TNNI3K
ECgene alternative splicing isoforms for
FPGT-TNNI3K

Expression for FPGT-TNNI3K Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FPGT-TNNI3K Gene

mRNA differential expression in normal tissues according to GTEx for FPGT-TNNI3K Gene

This gene is overexpressed in Heart - Left Ventricle (x7.7), Brain - Cerebellar Hemisphere (x6.0), and Brain - Cerebellum (x5.6).
genes like me logo Genes that share expression patterns with FPGT-TNNI3K: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FPGT-TNNI3K Gene

Orthologs for FPGT-TNNI3K Gene

This gene was present in the common ancestor of animals.

Orthologs for FPGT-TNNI3K Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNNI3K 34
  • 98 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TNNI3K 34
  • 95 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 93 (a)
ManyToMany
-- 34
  • 86 (a)
ManyToMany
-- 34
  • 14 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia TNNI3K 34
  • 93 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tnni3k 34
  • 90 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia TNNI3K 34
  • 88 (a)
OneToMany
chicken
(Gallus gallus)
Aves TNNI3K 34
  • 90 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 91 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tnni3k 34
  • 84 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C24A1.3 34
  • 42 (a)
OneToMany
Species where no ortholog for FPGT-TNNI3K was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FPGT-TNNI3K Gene

ENSEMBL:
Gene Tree for FPGT-TNNI3K (if available)
TreeFam:
Gene Tree for FPGT-TNNI3K (if available)

Paralogs for FPGT-TNNI3K Gene

Variants for FPGT-TNNI3K Gene

Sequence variations from dbSNP and Humsavar for FPGT-TNNI3K Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs606231469 Pathogenic 74,369,495(+) TGTGG(A/G)TGCTT reference, missense
rs1000001265 -- 74,334,881(+) ATTTA(C/G/T)GTAAA intron-variant
rs1000003344 -- 74,231,295(+) GGAAA(C/T)ATATT intron-variant
rs1000007289 -- 74,359,113(+) TACCA(A/C)CACAC intron-variant
rs1000007403 -- 74,272,523(+) AAGGA(C/T)CCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FPGT-TNNI3K Gene

Variant ID Type Subtype PubMed ID
dgv110n106 CNV deletion 24896259
dgv28e214 CNV gain 21293372
esv1000471 CNV deletion 20482838
esv1327381 CNV deletion 17803354
esv1932816 CNV deletion 18987734
esv2350476 CNV deletion 18987734
esv2549117 CNV deletion 19546169
esv2660597 CNV deletion 23128226
esv2749941 CNV deletion 23290073
esv2749952 CNV deletion 23290073
esv2749963 CNV deletion 23290073
esv2994845 CNV deletion 24192839
esv3310253 CNV mobile element insertion 20981092
esv3379315 CNV insertion 20981092
esv3564159 CNV deletion 23714750
esv3564181 CNV deletion 23714750
esv3586456 CNV loss 21293372
esv3586457 CNV loss 21293372
esv3586458 CNV loss 21293372
esv3893723 CNV gain 25118596
esv4202 CNV loss 18987735
esv6294 CNV gain 19470904
nsv1002115 CNV gain 25217958
nsv1003356 CNV loss 25217958
nsv1010042 CNV gain 25217958
nsv1078517 CNV deletion 25765185
nsv1142061 CNV tandem duplication 24896259
nsv1153966 CNV deletion 26484159
nsv461984 CNV loss 19166990
nsv522147 CNV loss 19592680
nsv523474 CNV loss 19592680
nsv525557 CNV loss 19592680
nsv546575 CNV loss 21841781
nsv546576 CNV loss 21841781
nsv546577 CNV loss 21841781
nsv820047 CNV loss 19587683
nsv830248 CNV loss 17160897
nsv954539 CNV deletion 24416366

Variation tolerance for FPGT-TNNI3K Gene

Gene Damage Index Score: 4.27; 62.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FPGT-TNNI3K Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FPGT-TNNI3K

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FPGT-TNNI3K Gene

Disorders for FPGT-TNNI3K Gene

Relevant External Links for FPGT-TNNI3K

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FPGT-TNNI3K

No disorders were found for FPGT-TNNI3K Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FPGT-TNNI3K Gene

Publications for FPGT-TNNI3K Gene

  1. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. (PMID: 25231870) Perry JR … Ong KK (Nature 2014) 3 60
  2. Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. (PMID: 23449627) Cousminer DL … Early Growth Genetics (EGG) Consortium (Human molecular genetics 2013) 3 60
  3. Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course. (PMID: 23669352) Graff M … Berndt SI (Human molecular genetics 2013) 3 60
  4. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PMID: 23563607) Berndt SI … Ingelsson E (Nature genetics 2013) 3 60
  5. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PMID: 20935630) Speliotes EK … Loos RJ (Nature genetics 2010) 3 60

Products for FPGT-TNNI3K Gene

Sources for FPGT-TNNI3K Gene

Content
Loading form....