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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FPGT Gene

protein-coding   GIFtS: 45
GCID: GC01P074663

Fucose-1-Phosphate Guanylyltransferase

  Search for FPGT
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fucose-1-Phosphate Guanylyltransferase1 2     GDP-Beta-L-Fucose Pyrophosphorylase2
GFPP2 3     EC 2.7.7.303
GDP-L-Fucose Diphosphorylase2 3     GDP-L-Fucose Pyrophosphorylase3
Fucose-1-Phosphate Guanyltransferase2     

External Ids:    HGNC: 38251   Entrez Gene: 87902   Ensembl: ENSG000002546857   OMIM: 6036095   UniProtKB: O147723   

Export aliases for FPGT gene to outside databases

Previous GC identifers: GC01P074785 GC01P073586 GC01P074048 GC01P074033 GC01P074375


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FPGT Gene:
L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the
functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these
fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of
GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene
participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and
appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and
glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then
condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form
GDP-beta-L-fucose. Alternative splicing results in multiple transcript variants. Read-through transcription also
exists between this gene and the neighboring downstream TNNI3 interacting kinase (TNNI3K) gene. (provided by
RefSeq, Dec 2010)

GeneCards Summary for FPGT Gene: 
FPGT (fucose-1-phosphate guanylyltransferase) is a protein-coding gene. Among its related super-pathways are Metabolism. GO annotations related to this gene include fucose-1-phosphate guanylyltransferase activity and GTP binding.

UniProtKB/Swiss-Prot: FPGT_HUMAN, O14772
Function: Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage
pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids

Gene Wiki entry for FPGT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FPGT gene promoter:
         AREB6   p53   GCNF   GCNF-1   c-Myb   STAT5A   GCNF-2   RSRFC4   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFPGT promoter sequence
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FPGT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.1

FPGT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FPGT gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P074663:  view genomic region     (about GC identifiers)

Start:
74,663,896 bp from pter      End:
74,699,770 bp from pter
Size:
35,875 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FPGT_HUMAN, O14772 (See protein sequence)
Recommended Name: Fucose-1-phosphate guanylyltransferase  
Size: 594 amino acids; 66599 Da
Subcellular location: Cytoplasm
Sequence caution: Sequence=BAG65299.1; Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: A6NMH3 B4DRX2 B4E2Y7 E9PNQ2 Q8N5J7
Alternative splicing: 6 isoforms:  O14772-1   Q59H18-1   Q59H18-3   Q59H18-4   O14772-2   O14772-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FPGT: NX_O14772

Explore proteomics data for FPGT at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14772

  • FPGT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FPGT Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001186257.2  NP_001186258.2  NP_003829.3  

    ENSEMBL proteins: 
     ENSP00000434934   ENSP00000434802   ENSP00000433044   ENSP00000359935   ENSP00000431733  
     ENSP00000359931   ENSP00000432819   ENSP00000433499  

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    Cloud-Clone Corp. Proteins for FPGT 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    FPGT for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR012120 Fucose-1-phosphate_GuaTrfase
     IPR012887 Fucokinase

    Graphical View of Domain Structure for InterPro Entry O14772

    ProtoNet protein and cluster: O14772

    1 Blocks protein domain: IPB012887 L-fucokinase


    FPGT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FPGT_HUMAN, O14772
    Function: Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage
    pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids
    Catalytic activity: GTP + beta-L-fucose 1-phosphate = diphosphate + GDP-L-fucose

         Enzyme Number (IUBMB): EC 2.7.7.301

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity TAS9804772
    GO:0005525GTP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
    GO:0016779nucleotidyltransferase activity ----
    GO:0047341fucose-1-phosphate guanylyltransferase activity IEA--
         
    FPGT for ontologies           About GeneDecksing


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    SwitchGear 3'UTR luciferase reporter plasmidFPGT 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FPGT About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.40
    2GDP-L-fucose biosynthesis II (from L-fucose)
    GDP-L-fucose biosynthesis II (from L-fucose)
    3Fructose and mannose metabolism
    Fructose and mannose metabolism
    4Amino sugar and nucleotide sugar metabolism
    Amino sugar and nucleotide sugar metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for FPGT
        GDP-L-fucose biosynthesis II (from L-fucose)


    3         Kegg Pathways  (Kegg details for FPGT):
        Fructose and mannose metabolism
    Amino sugar and nucleotide sugar metabolism
    Metabolic pathways


    FPGT for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FPGT

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006004fucose metabolic process TAS9804772

    FPGT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for FPGT

    6 HMDB Compounds for FPGT    About this table
    CompoundSynonyms CAS #PubMed Ids
    Fucose 1-phosphate(3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl)oxyphosphonate (see all 11)16562-58-6--
    GDP-L-fucoseGDP-beta-L-fucose (see all 5)15839-70-0--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about FPGT

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FPGT gene (3 alternative transcripts): 
    NM_001199328.2  NM_001199329.2  NM_003838.4  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000467578 ENST00000524915 ENST00000482102 ENST00000370898(uc010oqu.2 uc001dgb.2 uc010oqt.2)
    ENST00000529485 ENST00000370894 ENST00000534056 ENST00000472069
    miRNA
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate FPGT (see all 14):
    hsa-miR-187* hsa-miR-3146 hsa-miR-548v hsa-miR-222 hsa-miR-1279 hsa-miR-4282 hsa-miR-3647-3p hsa-miR-221
    SwitchGear 3'UTR luciferase reporter plasmidFPGT 3' UTR sequence
    Inhib. RNA
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    24/199 AceView cDNA sequences (see all 199):

    BU622977 AA707390 BX099674 BG940401 AY303691 AU127975 AA280262 AU130402 
    Z39211 NM_015978 BX501623 AI741185 BX112488 BQ722029 CK819259 BQ774566 
    AI298368 AF116826 BP342463 AI338977 AI375137 F12805 AA490306 AA758546 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FPGT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FPGT Expression
    About this image


    See FPGT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FPGT

    UniProtKB/Swiss-Prot: FPGT_HUMAN, O14772
    Tissue specificity: Expressed in many tissues

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FPGT gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fpgt1 , 5 fucose-1-phosphate guanylyltransferase1, 5 79.78(n)1
    75.39(a)1
      3 (79.53 cM)5
    755401  NM_029330.21  NP_083606.21 
     1550849215 
    chicken
    (Gallus gallus)
    Aves FPGT1 fucose-1-phosphate guanylyltransferase 66.67(n)
    62.89(a)
      100533998  NM_001204815.1  NP_001191744.1 
    lizard
    (Anolis carolinensis)
    Reptilia FPGT6
    fucose-1-phosphate guanylyltransferase
    64(a)
    1 ↔ 1
    GL343194.1(2367546-2380259)
    zebrafish
    (Danio rerio)
    Actinopterygii fpgt1 fucose-1-phosphate guanylyltransferase 58.07(n)
    55.87(a)
      553792  NM_001020754.2  NP_001018590.2 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_K03H1.131 Protein K03H1.13 45.49(n)
    32.04(a)
      4926919  NM_001083174.1  NP_001076643.1 


    ENSEMBL Gene Tree for FPGT (if available)
    TreeFam Gene Tree for FPGT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FPGT gene
    2 SIMAP similar genes for FPGT using alignment to 7 protein entries:     FPGT_HUMAN (see all proteins):
    FPGT-TNNI3K    TNNI3K

    FPGT for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    1 SNPs in FPGT are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0616504
    ----see VAR_0616502 P L mis40--------

    HapMap Linkage Disequilibrium report for FPGT (74663896 - 74699770 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FPGT:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv522147CNV Loss19592680
    dgv247n71CNV Loss21882294
    dgv246n71CNV Gain21882294
    dgv245n71CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FPGT for disorders           About MalaCards
    OMIM gene information: 603609    OMIM disorders: --


    FPGT for disorders           About GeneDecksing


    Export disorders for FPGT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FPGT gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with FPGT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GDP-L-fucose pyrophosphorylase: purification, cDNA cloning, and properties of the enzyme. (PubMed id 9804772)1, 2, 3, 9 Pastuszak I....Elbein A.D. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Substrate discrimination by the human GTP fucose pyrophosphorylase. (PubMed id 16086588)1, 9 Quirk S. and Seley K.L. (2005)
    4. Purification, crystallization and preliminary X-ray characterization of the human GTP fucose pyrophosphorylase. (PubMed id 16582493)1, 9 Quirk S. and Seley-Radtke K.L. (2006)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    8. Identification of catalytic amino acids in the human GTP fucose pyrophosphorylase active site. (PubMed id 16185085)1 Quirk S. and Seley K.L. (2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8790 HGNC: 3825 AceView: FPGTandTNNI3K Ensembl:ENSG00000254685 euGenes: HUgn8790
    ECgene: FPGT Kegg: 8790 H-InvDB: FPGT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FPGT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FPGT gene:
    Search GeneIP for patents involving FPGT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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     Proteins for FPGT
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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