Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FPGT Gene

Aliases for FPGT Gene

  • Fucose-1-Phosphate Guanylyltransferase 2 3
  • GFPP 3 4 6
  • GDP-L-Fucose Diphosphorylase 3 4
  • Fucose-1-Phosphate Guanyltransferase 3
  • GDP-Beta-L-Fucose Pyrophosphorylase 3
  • GDP-L-Fucose Pyrophosphorylase 4
  • EC 2.7.7.30 4

External Ids for FPGT Gene

Summaries for FPGT Gene

Entrez Gene Summary for FPGT Gene

  • L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream TNNI3 interacting kinase (TNNI3K) gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for FPGT Gene

FPGT (Fucose-1-Phosphate Guanylyltransferase) is a Protein Coding gene. Among its related pathways are Metabolism and Amino sugar and nucleotide sugar metabolism. GO annotations related to this gene include GTP binding and fucose-1-phosphate guanylyltransferase activity.

UniProtKB/Swiss-Prot for FPGT Gene

  • Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids

Gene Wiki entry for FPGT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FPGT Gene

Genomics for FPGT Gene

Genomic Location for FPGT Gene

Start:
74,198,212 bp from pter
End:
74,234,086 bp from pter
Size:
35,875 bases
Orientation:
Plus strand

Genomic View for FPGT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FPGT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FPGT Gene

Regulatory Elements for FPGT Gene

Proteins for FPGT Gene

  • Protein details for FPGT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14772-FPGT_HUMAN
    Recommended name:
    Fucose-1-phosphate guanylyltransferase
    Protein Accession:
    O14772
    Secondary Accessions:
    • A6NMH3
    • B4DRX2
    • B4E2Y7
    • E9PNQ2
    • Q8N5J7

    Protein attributes for FPGT Gene

    Size:
    594 amino acids
    Molecular mass:
    66599 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAG65299.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for FPGT Gene

neXtProt entry for FPGT Gene

Proteomics data for FPGT Gene at MOPED

Post-translational modifications for FPGT Gene

No Post-translational modifications

No data available for DME Specific Peptides for FPGT Gene

Domains for FPGT Gene

genes like me logo Genes that share domains with FPGT: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FPGT Gene

Function for FPGT Gene

Molecular function for FPGT Gene

UniProtKB/Swiss-Prot CatalyticActivity: GTP + beta-L-fucose 1-phosphate = diphosphate + GDP-L-fucose
UniProtKB/Swiss-Prot Function: Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids

Enzyme Numbers (IUBMB) for FPGT Gene

Gene Ontology (GO) - Molecular Function for FPGT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity TAS 9804772
GO:0005525 GTP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
GO:0047341 fucose-1-phosphate guanylyltransferase activity IEA --
genes like me logo Genes that share ontologies with FPGT: view

miRNA for FPGT Gene

miRTarBase miRNAs that target FPGT

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FPGT Gene

Localization for FPGT Gene

Subcellular locations from UniProtKB/Swiss-Prot for FPGT Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FPGT Gene COMPARTMENTS Subcellular localization image for FPGT gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for FPGT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with FPGT: view

Pathways for FPGT Gene

genes like me logo Genes that share pathways with FPGT: view

Pathways by source for FPGT Gene

Interacting Proteins for FPGT Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359935%0d%0a9606.ENSP00000288078%0d%0a9606.ENSP00000398803%0d%0a9606.ENSP00000370372%0d%0a
Selected Interacting proteins: ENSP00000359935 for FPGT Gene via STRING

Gene Ontology (GO) - Biological Process for FPGT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006004 fucose metabolic process TAS 9804772
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with FPGT: view

Compounds for FPGT Gene

(6) HMDB Compounds for FPGT Gene

Compound Synonyms Cas Number PubMed IDs
Fucose 1-phosphate
  • (3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl)oxyphosphonate
16562-58-6
GDP-L-fucose
  • GDP-beta-L-fucose
15839-70-0
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine triphosphate
  • 5'-GTP
86-01-1
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
genes like me logo Genes that share compounds with FPGT: view

Transcripts for FPGT Gene

Alternative Splicing Database (ASD) splice patterns (SP) for FPGT Gene

No ASD Table

Relevant External Links for FPGT Gene

GeneLoc Exon Structure for
FPGT
ECgene alternative splicing isoforms for
FPGT

Expression for FPGT Gene

mRNA expression in normal human tissues for FPGT Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FPGT Gene

mRNA Expression by UniProt/SwissProt for FPGT Gene

O14772-FPGT_HUMAN
Tissue specificity: Expressed in many tissues
genes like me logo Genes that share expressions with FPGT: view

Orthologs for FPGT Gene

This gene was present in the common ancestor of animals.

Orthologs for FPGT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FPGT 36
  • 98.37 (n)
  • 97.99 (a)
FPGT 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FPGT 36
  • 89.7 (n)
  • 85.91 (a)
FPGT 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FPGT 36
  • 89.91 (n)
  • 87.89 (a)
FPGT 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fpgt 36
  • 79.7 (n)
  • 75.26 (a)
Fpgt 16
Fpgt 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FPGT 37
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fpgt 36
  • 77.62 (n)
  • 73.74 (a)
chicken
(Gallus gallus)
Aves FPGT 36
  • 66.9 (n)
  • 63.75 (a)
FPGT 37
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FPGT 37
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fpgt 36
  • 59.06 (n)
  • 59.29 (a)
zebrafish
(Danio rerio)
Actinopterygii fpgt 36
  • 58.3 (n)
  • 56.23 (a)
fpgt 37
  • 54 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_K03H1.13 36
  • 45.99 (n)
  • 31.01 (a)
K03H1.13 37
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 39 (a)
OneToOne
Species with no ortholog for FPGT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FPGT Gene

ENSEMBL:
Gene Tree for FPGT (if available)
TreeFam:
Gene Tree for FPGT (if available)

Paralogs for FPGT Gene

Selected SIMAP similar genes for FPGT Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FPGT: view

No data available for Paralogs for FPGT Gene

Variants for FPGT Gene

Sequence variations from dbSNP and Humsavar for FPGT Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
VAR_061650 -

Structural Variations from Database of Genomic Variants (DGV) for FPGT Gene

Variant ID Type Subtype PubMed ID
nsv522147 CNV Loss 19592680
dgv245n71 CNV Gain 21882294
dgv246n71 CNV Gain 21882294
dgv247n71 CNV Loss 21882294

Relevant External Links for FPGT Gene

HapMap Linkage Disequilibrium report
FPGT

Disorders for FPGT Gene

No disorders were found for FPGT Gene.

No data available for UniProtKB/Swiss-Prot for FPGT Gene

Publications for FPGT Gene

  1. GDP-L-fucose pyrophosphorylase: purification, cDNA cloning, and properties of the enzyme. (PMID: 9804772) Pastuszak I. … Elbein A.D. (J. Biol. Chem. 1998) 2 3 4 23
  2. Substrate discrimination by the human GTP fucose pyrophosphorylase. (PMID: 16086588) Quirk S. … Seley K.L. (Biochemistry 2005) 3 23
  3. Purification, crystallization and preliminary X-ray characterization of the human GTP fucose pyrophosphorylase. (PMID: 16582493) Quirk S. … Seley-Radtke K.L. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2006) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Identification of catalytic amino acids in the human GTP fucose pyrophosphorylase active site. (PMID: 16185085) Quirk S. … Seley K.L. (Biochemistry 2005) 3

Products for FPGT Gene

Sources for FPGT Gene

Back to Top

Content