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Aliases for FPGT Gene

Aliases for FPGT Gene

  • Fucose-1-Phosphate Guanylyltransferase 2 3 5
  • GDP-L-Fucose Diphosphorylase 3 4
  • GFPP 3 4
  • Fucose-1-Phosphate Guanyltransferase 3
  • GDP-Beta-L-Fucose Pyrophosphorylase 3
  • GDP-L-Fucose Pyrophosphorylase 4
  • EC 4

External Ids for FPGT Gene

Previous GeneCards Identifiers for FPGT Gene

  • GC01P074785
  • GC01P073586
  • GC01P074048
  • GC01P074033
  • GC01P074375
  • GC01P074663

Summaries for FPGT Gene

Entrez Gene Summary for FPGT Gene

  • L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream TNNI3 interacting kinase (TNNI3K) gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for FPGT Gene

FPGT (Fucose-1-Phosphate Guanylyltransferase) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and fucose-1-phosphate guanylyltransferase activity.

UniProtKB/Swiss-Prot for FPGT Gene

  • Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids.

Gene Wiki entry for FPGT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FPGT Gene

Genomics for FPGT Gene

Regulatory Elements for FPGT Gene

Enhancers for FPGT Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FPGT on UCSC Golden Path with GeneCards custom track

Promoters for FPGT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FPGT on UCSC Golden Path with GeneCards custom track

Genomic Location for FPGT Gene

74,198,212 bp from pter
74,234,086 bp from pter
35,875 bases
Plus strand

Genomic View for FPGT Gene

Genes around FPGT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FPGT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FPGT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FPGT Gene

Proteins for FPGT Gene

  • Protein details for FPGT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fucose-1-phosphate guanylyltransferase
    Protein Accession:
    Secondary Accessions:
    • A6NMH3
    • B4DRX2
    • B4E2Y7
    • E9PNQ2
    • Q8N5J7

    Protein attributes for FPGT Gene

    594 amino acids
    Molecular mass:
    66599 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAG65299.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for FPGT Gene

neXtProt entry for FPGT Gene

Proteomics data for FPGT Gene at MOPED

Post-translational modifications for FPGT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FPGT Gene

Domains & Families for FPGT Gene

Suggested Antigen Peptide Sequences for FPGT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FPGT: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FPGT Gene

Function for FPGT Gene

Molecular function for FPGT Gene

UniProtKB/Swiss-Prot CatalyticActivity:
GTP + beta-L-fucose 1-phosphate = diphosphate + GDP-L-fucose.
UniProtKB/Swiss-Prot Function:
Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids.

Enzyme Numbers (IUBMB) for FPGT Gene

Gene Ontology (GO) - Molecular Function for FPGT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with FPGT: view
genes like me logo Genes that share phenotypes with FPGT: view

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FPGT Gene

Localization for FPGT Gene

Subcellular locations from UniProtKB/Swiss-Prot for FPGT Gene


Subcellular locations from

Jensen Localization Image for FPGT Gene COMPARTMENTS Subcellular localization image for FPGT gene
Compartment Confidence
cytosol 4

No data available for Gene Ontology (GO) - Cellular Components for FPGT Gene

Pathways & Interactions for FPGT Gene

genes like me logo Genes that share pathways with FPGT: view

Interacting Proteins for FPGT Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000359935 for FPGT Gene via STRING

Gene Ontology (GO) - Biological Process for FPGT Gene


No data available for SIGNOR curated interactions for FPGT Gene

Drugs & Compounds for FPGT Gene

(3) Drugs for FPGT Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Diphosphate Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(3) Additional Compounds for FPGT Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fucose 1-phosphate
  • (3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl)oxyphosphonate
  • (3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl)oxyphosphonic acid
  • 6-Deoxy-L-Galactopyranose 1-(dihydrogen phosphate)
  • 6-Deoxy-L-galactose 1-phosphate
  • b-L-Fucose 1-phosphate
  • (6-deoxy-beta-L-galactopyranosyl) ester
  • GDP Fucose
  • GDP-beta-L-Fucose
  • Guanosine diphosphate fucose
  • Guanosine diphosphofucose
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
genes like me logo Genes that share compounds with FPGT: view

Transcripts for FPGT Gene

Alternative Splicing Database (ASD) splice patterns (SP) for FPGT Gene

No ASD Table

Relevant External Links for FPGT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FPGT Gene

mRNA expression in normal human tissues for FPGT Gene

Protein differential expression in normal tissues from HIPED for FPGT Gene

This gene is overexpressed in Testis (8.4), Islet of Langerhans (7.4), Stomach (6.2), and Pancreas (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for FPGT Gene

mRNA Expression by UniProt/SwissProt for FPGT Gene

Tissue specificity: Expressed in many tissues.
genes like me logo Genes that share expression patterns with FPGT: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for FPGT Gene

Orthologs for FPGT Gene

This gene was present in the common ancestor of animals.

Orthologs for FPGT Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FPGT 35
  • 89.7 (n)
  • 85.91 (a)
  • 84 (a)
(Canis familiaris)
Mammalia FPGT 35
  • 89.91 (n)
  • 87.89 (a)
  • 85 (a)
(Mus musculus)
Mammalia Fpgt 35
  • 79.7 (n)
  • 75.26 (a)
Fpgt 16
Fpgt 36
  • 74 (a)
(Pan troglodytes)
Mammalia FPGT 35
  • 98.37 (n)
  • 97.99 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Fpgt 35
  • 77.62 (n)
  • 73.74 (a)
(Ornithorhynchus anatinus)
Mammalia FPGT 36
  • 66 (a)
(Gallus gallus)
Aves FPGT 35
  • 66.9 (n)
  • 63.75 (a)
  • 62 (a)
(Anolis carolinensis)
Reptilia FPGT 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fpgt 35
  • 59.06 (n)
  • 59.29 (a)
(Danio rerio)
Actinopterygii fpgt 35
  • 58.3 (n)
  • 56.23 (a)
fpgt 36
  • 54 (a)
(Caenorhabditis elegans)
Secernentea CELE_K03H1.13 35
  • 45.99 (n)
  • 31.01 (a)
K03H1.13 36
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for FPGT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FPGT Gene

Gene Tree for FPGT (if available)
Gene Tree for FPGT (if available)

Paralogs for FPGT Gene

(1) SIMAP similar genes for FPGT Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FPGT: view

No data available for Paralogs for FPGT Gene

Variants for FPGT Gene

Sequence variations from dbSNP and Humsavar for FPGT Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_061650 -

Structural Variations from Database of Genomic Variants (DGV) for FPGT Gene

Variant ID Type Subtype PubMed ID
nsv522147 CNV Loss 19592680
dgv245n71 CNV Gain 21882294
dgv246n71 CNV Gain 21882294
dgv247n71 CNV Loss 21882294

Variation tolerance for FPGT Gene

Gene Damage Index Score: 1.92; 35.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FPGT Gene

Disorders for FPGT Gene

Relevant External Links for FPGT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FPGT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FPGT Gene

Publications for FPGT Gene

  1. GDP-L-fucose pyrophosphorylase: purification, cDNA cloning, and properties of the enzyme. (PMID: 9804772) Pastuszak I. … Elbein A.D. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. Purification, crystallization and preliminary X-ray characterization of the human GTP fucose pyrophosphorylase. (PMID: 16582493) Quirk S. … Seley-Radtke K.L. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2006) 3 23
  3. Substrate discrimination by the human GTP fucose pyrophosphorylase. (PMID: 16086588) Quirk S. … Seley K.L. (Biochemistry 2005) 3 23
  4. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for FPGT Gene

Sources for FPGT Gene