FPGT Gene
protein-coding GIFtS: 44
GCID: GC01P074663
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fucose-1-phosphate guanylyltransferase
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Aliases
for FPGT gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fucose-1-Phosphate Guanylyltransferase1 2 | | GDP-Beta-L-Fucose Pyrophosphorylase2 | | GFPP1 2 3 | | EC 2.7.7.303 | | GDP-L-Fucose Diphosphorylase2 3 | | GDP-L-Fucose Pyrophosphorylase3 | | Fucose-1-Phosphate Guanyltransferase2 | | |
Export aliases for FPGT gene to outside databasesPrevious GC identifers: GC01P074785 GC01P073586 GC01P074048 GC01P074033 GC01P074375 |
Summaries
for FPGT gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FPGT:
L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of thefunctional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylatedoligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose; the majorpathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in analternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as asalvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathwayinvolves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of thebeta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose. Alternativesplicing results in multiple transcript variants. Read-through transcription also exists between this gene and theneighboring downstream TNNI3 interacting kinase (TNNI3K) gene. (provided by RefSeq, Dec 2010)
UniProtKB/Swiss-Prot: FPGT_HUMAN, O14772Function: Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway toreutilize L-fucose arising from the turnover of glycoproteins and glycolipids
Gene Wiki entry for FPGT
|
Genomic Views
for FPGT gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FPGT gene promoter:
AREB6 p53 GCNF GCNF-1 c-Myb STAT5A GCNF-2 RSRFC4 GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FPGT
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FPGT |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p31.1 Ensembl cytogenetic band: 1p31.1 HGNC cytogenetic band: 1p31.1FPGT Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P074663: view genomic region
(about GC identifiers)
Start:
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74,663,922 bp from pter |
End:
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74,699,770 bp from pter |
Size:
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35,849 bases |
Orientation:
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plus strand |
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Proteins
for FPGT gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FPGT_HUMAN, O14772 (See
protein sequence)Recommended Name: Fucose-1-phosphate guanylyltransferase Size: 594 amino acids; 66599 Da
Subcellular location: Cytoplasm
Secondary accessions: B4DRX2 E9PNQ2 Q8N5J7Alternative splicing: 5 isoforms: O14772-1 Q59H18-1 Q59H18-3 Q59H18-4 O14772-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FPGT: NX_O14772
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O14772
FPGT Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001186257.1 NP_001186258.1 NP_003829.2
ENSEMBL proteins: ENSP00000434934 ENSP00000434802 ENSP00000433044 ENSP00000359935 ENSP00000431733 ENSP00000359931 ENSP00000432819 ENSP00000433499
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
FPGT for ontologies About GeneDecksing
FPGT Antibody Products:
Assay Products for FPGT: |
Protein
Domains /
Families
for FPGT gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FPGT for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O14772ProtoNet protein and cluster: O14772 1 Blocks protein family: IPB012887 L-fucokinase
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Function
for FPGT gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FPGT_HUMAN, O14772Function: Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway toreutilize L-fucose arising from the turnover of glycoproteins and glycolipidsCatalytic activity: GTP + beta-L-fucose 1-phosphate = diphosphate + GDP-L-fucoseEnzyme Number (IUBMB): EC 2.7.7.301
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FPGT
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for FPGT | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FPGT |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FPGT |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003824 | catalytic activity |
TAS | 9804772 | | GO:0005525 | GTP binding |
IEA | -- | | GO:0016772 | transferase activity, transferring phosphorus-containing groups |
-- | -- | | GO:0016779 | nucleotidyltransferase activity |
-- | -- | | GO:0047341 | fucose-1-phosphate guanylyltransferase activity |
IEA | -- |
FPGT for ontologies About GeneDecksing
|
Pathways & Interactions
for FPGT gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | GDP-L-fucose biosynthesis II (from L-fucose) | | | 2 | Amino sugar and nucleotide sugar metabolism | | | 3 | Fructose and mannose metabolism | | | 4 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for FPGT
3 
Kegg Pathways (Kegg details for FPGT):
FPGT for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FPGT
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006004 | fucose metabolic process |
TAS | 9804772 |
FPGT for ontologies About GeneDecksing
|
Drugs & Compounds
for FPGT gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FPGT
6 HMDB Compounds for FPGT About this table
Search CenterWatch for drugs/clinical trials and news about FPGT
|
Transcripts
for FPGT gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FPGT gene (3 alternative transcripts): NM_001199328.1 NM_001199329.1 NM_003838.3 8 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000467578 ENST00000524915 ENST00000482102 ENST00000370898(uc010oqu.2 uc001dgb.2 uc010oqt.2)
ENST00000529485 ENST00000370894 ENST00000534056 ENST00000472069
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FPGT (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FPGT
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): FPGT (NM_001199329) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FPGT | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FPGT |
24/199 AceView cDNA sequences (see all 199): AA490306 AW475012 BP342463 AF116826 AA938871 AI298368 AI383084 CK819259 Z39211 AI338977 BQ722029 AY303691 AU130402 BQ774566 Z43126 AA758546 AI375137 AA707390 BX112488 AI377988 F12805 AU127975 BG940401 AA280262
GeneLoc Exon Structure
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Expression
for FPGT gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FPGT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See FPGT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FPGT
UniProtKB/Swiss-Prot: FPGT_HUMAN, O14772Tissue specificity: Expressed in many tissues
SABiosciences Custom PCR Arrays for FPGT
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FPGT
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FPGT | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FPGT | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FPGT | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FPGT |
Orthologs
for FPGT gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FPGT gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for FPGT (if available)
TreeFam Gene Tree for FPGT (if available) |
Paralogs
for FPGT gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FPGT gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FPGT (74663922 - 74699770 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FPGT: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for FPGT gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 FPGT for disorders About MalaCards
FPGT for disorders About GeneDecksing
OMIM gene information: 603609
OMIM disorders: --
Export disorders for FPGT gene to outside databases
|
Publications
for FPGT gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FPGT gene integrated from 9 sources:
(articles sorted by number of sources associating them with FPGT) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- GDP-L-fucose pyrophosphorylase: purification, cDNA cloning, and properties of the enzyme. (PubMed id 9804772)1, 2, 3, 9 Pastuszak I....Elbein A.D. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Substrate discrimination by the human GTP fucose pyrophosphorylase. (PubMed id 16086588)1, 9 Quirk S. and Seley K.L. (2005)
- Purification, crystallization and preliminary X-ray characterization of the human GTP fucose pyrophosphorylase. (PubMed id 16582493)1, 9 Quirk S. and Seley-Radtke K.L. (2006)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Identification of catalytic amino acids in the human GTP fucose pyrophosphorylase active site. (PubMed id 16185085)1 Quirk S. and Seley K.L. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
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External Searches for FPGT gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FPGT gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FPGT gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FPGT gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FPGT | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FPGT gene:
Search GeneIP for patents involving FPGT
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FPGT gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FPGT | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FPGT | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FPGT | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FPGT | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FPGT | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FPGT |
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 | | | FPGT Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FPGT |
|  |  |  | | | | ThermoFisher Antibodies for FPGT |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FPGT |
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