FPGS Gene
protein-coding GIFtS: 60
GCID: GC09P130556
|
|
folylpolyglutamate synthase
| |
Aliases
for FPGS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Folylpolyglutamate Synthase1 2 | | Folylpoly-Gamma-Glutamate Synthetase2 3 | | Tetrahydrofolate Synthase2 3 | | Tetrahydrofolylpolyglutamate Synthase2 3 | | EC 6.3.2.173 8 | | Folylpolyglutamate Synthase, Mitochondrial2 |
Export aliases for FPGS gene to outside databasesPrevious GC identifers: GC09P121679 GC09P122211 GC09P124018 GC09P125941 GC09P127644 GC09P129604 GC09P100181 |
Summaries
for FPGS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FPGS:
This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing andmaintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folatehomeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamatemoieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-lengthnatures of only two have been biologically validated to date. These two variants encode distinct isoforms. (providedby RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: FOLC_HUMAN, Q05932Function: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds inthe cell and the intracellular retention of these cofactors, which are important substrates for most of thefolate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and aminoacid synthesis. Unsubstitued reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) topolyglutamates
Gene Wiki entry for FPGS
|
Genomic Views
for FPGS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FPGS gene promoter:
p53 p300 ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for FPGS
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FPGS |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.1 Ensembl cytogenetic band: 9q34.11 HGNC cytogenetic band: 9cen-q34FPGS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P130556: view genomic region
(about GC identifiers)
Start:
|
130,556,876 bp from pter |
End:
|
130,576,606 bp from pter |
Size:
|
19,731 bases |
Orientation:
|
plus strand |
|
Proteins
for FPGS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FOLC_HUMAN, Q05932 (See
protein sequence)Recommended Name: Folylpolyglutamate synthase, mitochondrial precursor Size: 587 amino acids; 64609 Da
Cofactor: A monovalent cation. K(+) is most effective, followed by NH4(+) and Rb(+). Na(+), Li(+) and Cs(+) areineffective
Subunit: Monomer
Subcellular location: Isoform 1: Mitochondrion inner membrane. Mitochondrion matrix
Subcellular location: Isoform 2: Cytoplasm
Sequence caution: Sequence=AAA35852.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B3KPW4 B7Z2Z3 F5H0K6 Q5JU19 Q5JU22 Q6P2P6Alternative splicing, Alternative initiation: 4 isoforms: Q05932-1 Q05932-2 Q05932-3 Q05932-4 (Produced by alternative splicing of isoform 1)Explore the universe of human proteins at neXtProt for FPGS: NX_Q05932
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q05932
4/5 DME Specific Peptides for FPGS (Q05932) (see all 5)
FPGS Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001018088.1 NP_004948.4
ENSEMBL proteins: ENSP00000362344 ENSP00000362325 ENSP00000362322 ENSP00000400007 ENSP00000406328 ENSP00000377309 ENSP00000362342 Reactome Protein details: Q05932
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
FPGS for ontologies About GeneDecksing
FPGS Antibody Products:
Assay Products for FPGS: |
Protein
Domains /
Families
for FPGS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FPGS for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q05932ProtoNet protein and cluster: Q05932 1 Blocks protein family: IPB001645 Folylpolyglutamate synthetase
UniProtKB/Swiss-Prot: FOLC_HUMAN, Q05932Similarity: Belongs to the folylpolyglutamate synthase family |
Function
for FPGS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FOLC_HUMAN, Q05932Function: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds inthe cell and the intracellular retention of these cofactors, which are important substrates for most of thefolate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and aminoacid synthesis. Unsubstitued reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) topolyglutamatesCatalytic activity: ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate +tetrahydropteroyl-(gamma-Glu)(n+1)Enzyme regulation: Activated by 10 mM sodium bicarbonateBiophysicochemical properties: Kinetic parameters: KM=201 uM for L-glutamate (isoform 2 at 37 degrees Celsius in thepresence of 1 mM ATP and 2 mM L-glutamate); KM=200 uM for MgATP (isoform 2 at 37 degrees Celsius in the presence of 1mM ATP and 2 mM L-glutamate); KM=59 uM for pteroylglutamic acid (PteGlu) (isoform 2 at 37 degrees Celsius in thepresence of 1 mM ATP and 2 mM L- glutamate); KM=16 uM for PteGlu(2) (isoform 2 at 37 degrees Celsius in the presenceof 1 mM ATP and 2 mM L-glutamate); KM=20 uM for PteGlu(3) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATPand 2 mM L-glutamate); KM=12 uM for PteGlu(4) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mML-glutamate); KM=64 uM for PteGlu(5) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mML-glutamate); KM=0.81 uM for H(2)PteGlu (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mML-glutamate); KM=47 uM for H(2)PteGlu(2) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mML-glutamate); KM=1.6 uM for (6ambo)-tetrahydropteroylpoly-gamma-glutamate (H(4)PteGlu) (isoform 2 at 37 degreesCelsius in the presence of 1 mM ATP and 2 mM L-glutamate); KM=4.4 uM for (6S)-H(4)PteGlu (isoform 2 at 37 degreesCelsius in the presence of 1 mM ATP and 2 mM L-glutamate); KM=3.3 uM for (6S)-H(4)PteGlu(2) (isoform 2 at 37 degreesCelsius in the presence of 1 mM ATP and 2 mM L-glutamate); KM=1.4 uM for (6S)-H(4)PteGlu(3) (isoform 2 at 37 degreesCelsius in the presence of 1 mM ATP and 2 mM L-glutamate); KM=1.6 uM for (6S)-H(4)PteGlu(4) (isoform 2 at 37 degreesCelsius in the presence of 1 mM ATP and 2 mM L-glutamate); KM=1.4 uM for (6S)-H(4)PteGlu(5) (isoform 2 at 37 degreesCelsius in the presence of 1 mM ATP and 2 mM L-glutamate); KM=3.7 uM for (6R)-10-formyl-H(4)PteGlu (isoform 2 at 37degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate); KM=2.7 uM for (6R)-10-formyl-H(4)PteGlu(2) (isoform2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate); KM=105 uM for (6S)-5-formyl-H(4)PteGlu(isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate); KM=13 uM for(6S)-5-formyl-H(4)PteGlu(2) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate); KM=48uM for (6S)-5-methyl-H(4)PteGlu (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate);KM=4.4 uM for aminopterin (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate); KM=55.5uM for methotrexate (isoform 2, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5);KM=52.6 uM for methotrexate (isoform 1, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH8.5); KM=71 uM for methotrexate (Glu-1) (isoform 2, PubMed:8662720, at 37 degrees Celsius in the presence of 1 mM ATPand 2 mM L- glutamate); KM=50 uM for methotrexate (Glu-2) (isoform 2, PubMed:8662720, at 37 degrees Celsius in thepresence of 1 mM ATP and 2 mM L- glutamate); KM=148 uM for methotrexate (Glu-3) (isoform 2, PubMed:8662720, at 37degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate); KM=5.3 uM for 5-deazaacyclotetrahydrofolate(isoform 2, at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate); KM=2.8 uM for2-methyl-5,8-dideazaisofolate (isoform 2, at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate);KM=1702 uM for glutamic acid (isoform 2, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH8.5); KM=2068 uM for glutamic acid (isoform 1, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP andpH 8.5); Vmax=0.34 umol/h/mg enzyme with methotrexate as substrate (isoform 2, PubMed:17875718, at 37 degrees Celsiusin the presence of 10 mM ATP and pH 8.5); Vmax=0.05 umol/h/mg enzyme with methotrexate as substrate (isoform 1,PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5); Vmax=1.26 umol/h/mg enzyme withglutamic acid as substrate (isoform 2, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH8.5); Vmax=0.25 umol/h/mg enzyme with glutamic acid as substrate (isoform 1, PubMed:17875718, at 37 degrees Celsius inthe presence of 10 mM ATP and pH 8.5); pH dependence: Optimum pH is 9.6 (isoform 2); Genatlas biochemistry entry for FPGS:folylpoly-gamma-glutamate synthase
Enzyme Number (IUBMB): EC 6.3.2.171 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FPGS (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FPGS (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): FPGS (NM_004957) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FPGS | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FPGS |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FPGS |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004326 | tetrahydrofolylpolyglutamate synthase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- |
FPGS for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for FPGS:
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Fpgs):
FPGS for phenotypes About GeneDecksing
|
Pathways & Interactions
for FPGS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Metabolism | | | 2 | Fluoropyrimidine Activity | | | 3 | glycine biosynthesis I | | | 4 | Vitamin B5 (pantothenate) metabolism | | | 5 | Folate biosynthesis | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for FPGS
4 
Reactome Pathways for FPGS
2  PharmGKB Pathways for FPGS
2 
Kegg Pathways (Kegg details for FPGS):
UniProtKB/Swiss-Prot: FOLC_HUMAN, Q05932Pathway: Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis
FPGS for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FPGS
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/55 Interacting proteins for FPGS (Q059323 ENSP000003623444) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table
FPGS for ontologies About GeneDecksing
|
Drugs & Compounds
for FPGS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
FPGS for compounds About GeneDecksing
 Browse Tocris compounds for FPGS
10 HMDB Compounds for FPGS About this table
3 DrugBank Compounds for FPGS About this table
10/47 Novoseek chemical compound relationships for FPGS gene (see all 47) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| lometrexol |
93.5 |
12 |
8869756 (2), 8937460 (1), 7565626 (1), 10598554 (1) (see all 8) |
| glycinamide ribonucleotide |
93.2 |
8 |
7565626 (1), 8027993 (1), 10598551 (1), 11469716 (1) (see all 7) |
| tomudex |
93.2 |
30 |
10477170 (5), 7646540 (3), 7513935 (2), 8255099 (1) (see all 14) |
| 1843u89 |
93.1 |
6 |
8764125 (4), 9816025 (1), 9242558 (1) |
| thymidylate |
92.2 |
52 |
10598551 (2), 9825730 (1), 10699949 (1), 16078850 (1) (see all 32) |
| zd9331 |
91.7 |
5 |
9654109 (1), 8624289 (1), 12721264 (1), 9815766 (1) |
| 5-deazafolate |
90.2 |
9 |
1578484 (2), 7565626 (1), 12408727 (1), 10479284 (1) |
| dihydrofolate |
89 |
32 |
1835598 (1), 8568827 (1), 9778690 (1), 10699949 (1) (see all 22) |
| folate |
89 |
283 |
8937460 (6), 8408018 (6), 8408019 (6), 18025275 (4) (see all 95) |
| aminopterin |
86.4 |
10 |
2007575 (1), 7506026 (1), 7565626 (1), 9744777 (1) (see all 6) |
1 PharmGKB related drug/compound annotation for FPGS geneAbout this table
Search CenterWatch for drugs/clinical trials and news about FPGS / FOLC
|
Transcripts
for FPGS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FPGS gene (2 alternative transcripts): NM_001018078.1 NM_004957.4 Unigene Cluster for FPGS: Folylpolyglutamate synthase Hs.335084 [show with all ESTs]Unigene Representative Sequence: NM_00495718/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22): ENST00000479147(uc004bsf.1) ENST00000479375 ENST00000373247 ENST00000488307
ENST00000373228 ENST00000481552 ENST00000460181 ENST00000475765 ENST00000496586
ENST00000373225(uc004bsi.1) ENST00000431857 ENST00000469468 ENST00000423577
ENST00000469310 ENST00000497386 ENST00000488506 ENST00000489522 ENST00000467826
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FPGS (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FPGS (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FPGS (NM_004957) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FPGS | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FPGS |
Additional cDNA sequence: AK056920.1 AK295309.1 AK315523.1 AY007210.1 AY007211.1 AY007212.1 BC007121.1 BC009901.2 BC064393.1 BT006639.1 M98045.1 18 DOTS entries: DT.100852186 DT.100030070 DT.92449883 DT.100640867 DT.100871571 DT.121190252 DT.95361622 DT.95361621 DT.40105946 DT.95361628 DT.95361629 DT.100659299 DT.121617824 DT.92449874 DT.92449886 DT.97764328 DT.97796004 DT.97854091 24/407 AceView cDNA sequences (see all 407): AL526394 BQ686518 AI082295 BE207410 AI687246 AA298722 AI351075 BE531124 BG014233 BM818657 CD619492 AY007210 AV726005 BF514175 M98045 BQ643944 AW301211 BX436442 BQ955185 CR589995 CR620207 BM984246 BU521573 BU854910
GeneLoc Exon Structure
5/15 Alternative Splicing Database (ASD) splice patterns (SP) for FPGS (see all 15) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14 | ^ |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | | | - | | - | | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | - | | - | | - | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | - | | - | | | | - | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | - | | - | | | | - | | - | | - | | | | | | | | | |
| ExUns: | 15 | ^ | 16a | · | 16b | ^ | 17 |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | | | | | |
| SP3: | | | | | | | | | |
| SP4: | | | | | | | | | |
| SP5: | | | | | | | | |
ECgene alternative splicing isoforms for FPGS
|
Expression
for FPGS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FPGS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See FPGS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FPGS
SOURCE GeneReport for Unigene cluster: Hs.335084
SABiosciences Custom PCR Arrays for FPGS
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FPGS
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FPGS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FPGS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FPGS | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FPGS |
Orthologs
for FPGS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for FPGS gene from 10/34 species (see all 34) About this table
ENSEMBL Gene Tree for FPGS (if available)
TreeFam Gene Tree for FPGS (if available) |
Paralogs
for FPGS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FPGS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FPGS (130556876 - 130576606 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FPGS: --
Human Gene Mutation Database (HGMD): FPGS
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FPGS |
|
Disorders
/ Diseases
for FPGS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FPGS for disorders About GeneDecksing
OMIM gene information: 136510
OMIM disorders: --
20/35  diseases for FPGS (see all 35): About MalaCardsdiffuse large b-cell lymphoma b-cell lymphomas malignant pleural mesothelioma non-hodgkin lymphoma
soft tissue sarcoma spina bifida lymphoblastic leukemia cleft lip
hodgkin's lymphoma acute lymphoblastic leukemia rheumatoid arthritis leukemia
follicular lymphoma childhood leukemia acute leukemia colon cancer
sarcoma colorectal cancer arthritis breast cancer
10/26 Novoseek disease relationships for FPGS gene (see all 26) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leukemia |
58.3 |
32 |
19131550 (3), 8255099 (2), 11309345 (2), 2007575 (1) (see all 21) |
| folate deficiency |
50.9 |
4 |
15047700 (1), 18499665 (1), 8869756 (1), 18804693 (1) |
| lymphoblastic leukemia acute |
48.4 |
8 |
1435744 (2), 9654109 (1), 19131550 (1), 9242558 (1) (see all 6) |
| t-all |
47.6 |
9 |
16707018 (4), 10029597 (3), 11187907 (1) |
| colorectal cancer |
46.9 |
7 |
20037791 (2), 18418463 (1), 14676127 (1) |
| tumors |
43.1 |
78 |
8937460 (4), 14676127 (4), 1450491 (3), 18039426 (3) (see all 39) |
| leukemia l1210 |
42.7 |
1 |
8605241 (1) |
| leukemia nonlymphocytic acute |
36.8 |
1 |
10777604 (1) |
| colon cancer |
34.4 |
10 |
15542523 (4), 20037791 (1), 12907242 (1), 14676127 (1) |
| lymphoblastic leukemia acute childhood |
31 |
1 |
20072153 (1) |
Human Genome Epidemiology (HuGE) Navigator: FPGS (17 documents)
Export disorders for FPGS gene to outside databases
|
Publications
for FPGS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FPGS gene, integrated from 9 sources (see all 234):
(articles sorted by number of sources associating them with FPGS) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of genetic variation in the folylpolyglutamate synthase gene. (PubMed id 17875718)1, 2, 9 Leil T.A....Adjei A.A. (2007)
- Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene. (PubMed id 8662720)1, 2, 9 Chen L....Shane B. (1996)
- Upstream organization of and multiple transcripts from the human folylpoly-gamma-glutamate synthetase gene. (PubMed id 7721888)1, 2, 9 Freemantle S.J.... Moran R.G. (1995)
- Concentration-dependent processivity of multiple glutamate ligations catalyzed by folylpoly-gamma-glutamate synthetase. (PubMed id 18672898)1, 2, 9 Tomsho J.W....Coward J.K. (2008)
- Submitochondrial localization of the mitochondrial isoform of folylpolyglutamate synthetase in CCRF-CEM human T-lymphoblastic leukemia cells. (PubMed id 16169100)1, 2, 9 Nair J.R. and McGuire J.J. (2005)
- Expression cloning of a human cDNA encoding folylpoly(gamma- glutamate) synthetase and determination of its primary structure. (PubMed id 1409616)1, 2, 9 Garrow T.A.... Shane B. (1992)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Structural organization of the human folypoly-gamma-glutamate synthetase gene: evidence for a single genomic locus. (PubMed id 8521387)1, 2 Taylor S.M.... Moran R.G. (1995)
- Analysis of folylpoly-gamma-glutamate synthetase gene expression in human B-precursor ALL and T-lineage ALL cells. (PubMed id 16707018)1, 9 Leclerc G.J....Barredo J.C. (2006)
- Regulation of folate and one-carbon metabolism in mammalian cells. I. Folate metabolism in Chinese hamster ovary cells expressing Escherichia coli or human folylpoly-gamma-glutamate synthetase activity. (PubMed id 8408018)2, 9 Osborne C.B....Shane B. (1993)
|
External Searches for FPGS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FPGS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FPGS gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FPGS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FPGS | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FPGS gene:
Search GeneIP for patents involving FPGS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FPGS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FPGS | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FPGS | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FPGS | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FPGS | | OriGene 3'-UTR Clone for FPGS | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FPGS | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FPGS | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FPGS | | OriGene Custom Protein Services for FPGS | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FPGS | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FPGS | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FPGS | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FPGS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FPGS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FPGS |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FPGS |
|  |  |  | | | | Search ThermoFisher Antibodies for FPGS |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FPGS |
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