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Aliases for FPGS Gene

Aliases for FPGS Gene

  • Folylpolyglutamate Synthase 2 3
  • EC 6.3.2.17 4 63
  • Tetrahydrofolylpolyglutamate Synthase 4
  • Folylpoly-Gamma-Glutamate Synthetase 4
  • Tetrahydrofolate Synthase 4

External Ids for FPGS Gene

Previous GeneCards Identifiers for FPGS Gene

  • GC09P121679
  • GC09P122211
  • GC09P124018
  • GC09P125941
  • GC09P127644
  • GC09P129604
  • GC09P130556
  • GC09P100181

Summaries for FPGS Gene

Entrez Gene Summary for FPGS Gene

  • This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]

GeneCards Summary for FPGS Gene

FPGS (Folylpolyglutamate Synthase) is a Protein Coding gene. Diseases associated with FPGS include soft tissue sarcoma and colorectal cancer. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include tetrahydrofolylpolyglutamate synthase activity.

UniProtKB/Swiss-Prot for FPGS Gene

  • Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstitued reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates.

Gene Wiki entry for FPGS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FPGS Gene

Genomics for FPGS Gene

Regulatory Elements for FPGS Gene

Transcription factor binding sites by QIAGEN in the FPGS gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FPGS Gene

Start:
127,794,597 bp from pter
End:
127,814,520 bp from pter
Size:
19,924 bases
Orientation:
Plus strand

Genomic View for FPGS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FPGS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FPGS Gene

Proteins for FPGS Gene

  • Protein details for FPGS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05932-FOLC_HUMAN
    Recommended name:
    Folylpolyglutamate synthase, mitochondrial
    Protein Accession:
    Q05932
    Secondary Accessions:
    • B3KPW4
    • B7Z2Z3
    • F5H0K6
    • Q5JU19
    • Q5JU22
    • Q6P2P6

    Protein attributes for FPGS Gene

    Size:
    587 amino acids
    Molecular mass:
    64609 Da
    Cofactor:
    Name=K(+); Xref=ChEBI:CHEBI:29103; Name=NH4(+); Xref=ChEBI:CHEBI:28938; Note=A monovalent cation. K(+) is most effective, followed by NH4(+) and Rb(+). Na(+), Li(+) and Cs(+) are ineffective.;
    Quaternary structure:
    • Monomer
    SequenceCaution:
    • Sequence=AAA35852.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FPGS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FPGS Gene

Proteomics data for FPGS Gene at MOPED

Selected DME Specific Peptides for FPGS Gene

Post-translational modifications for FPGS Gene

  • Ubiquitination at Lys66, Lys107, Lys124, Lys154, and Lys248
  • Modification sites at PhosphoSitePlus

Other Protein References for FPGS Gene

Domains for FPGS Gene

Graphical View of Domain Structure for InterPro Entry

Q05932

UniProtKB/Swiss-Prot:

FOLC_HUMAN :
  • Q05932
Family:
  • Belongs to the folylpolyglutamate synthase family.
genes like me logo Genes that share domains with FPGS: view

No data available for Gene Families for FPGS Gene

Function for FPGS Gene

Molecular function for FPGS Gene

GENATLAS Biochemistry: folylpoly-gamma-glutamate synthase
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=201 uM for L-glutamate (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=200 uM for MgATP (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=59 uM for pteroylglutamic acid (PteGlu) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=16 uM for PteGlu(2) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=20 uM for PteGlu(3) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=12 uM for PteGlu(4) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=64 uM for PteGlu(5) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=0.81 uM for H(2)PteGlu (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=47 uM for H(2)PteGlu(2) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=1.6 uM for (6ambo)-tetrahydropteroylpoly-gamma-glutamate (H(4)PteGlu) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=4.4 uM for (6S)-H(4)PteGlu (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=3.3 uM for (6S)-H(4)PteGlu(2) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=1.4 uM for (6S)-H(4)PteGlu(3) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=1.6 uM for (6S)-H(4)PteGlu(4) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=1.4 uM for (6S)-H(4)PteGlu(5) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=3.7 uM for (6R)-10-formyl-H(4)PteGlu (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=2.7 uM for (6R)-10-formyl-H(4)PteGlu(2) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=105 uM for (6S)-5-formyl-H(4)PteGlu (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=13 uM for (6S)-5-formyl-H(4)PteGlu(2) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=48 uM for (6S)-5-methyl-H(4)PteGlu (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=4.4 uM for aminopterin (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=55.5 uM for methotrexate (isoform 2, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=52.6 uM for methotrexate (isoform 1, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=71 uM for methotrexate (Glu-1) (isoform 2, PubMed:8662720, at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=50 uM for methotrexate (Glu-2) (isoform 2, PubMed:8662720, at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=148 uM for methotrexate (Glu-3) (isoform 2, PubMed:8662720, at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=5.3 uM for 5-deazaacyclotetrahydrofolate (isoform 2, at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=2.8 uM for 2-methyl-5,8-dideazaisofolate (isoform 2, at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=1702 uM for glutamic acid (isoform 2, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=2068 uM for glutamic acid (isoform 1, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; Vmax=0.34 umol/h/mg enzyme with methotrexate as substrate (isoform 2, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; Vmax=0.05 umol/h/mg enzyme with methotrexate as substrate (isoform 1, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; Vmax=1.26 umol/h/mg enzyme with glutamic acid as substrate (isoform 2, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; Vmax=0.25 umol/h/mg enzyme with glutamic acid as substrate (isoform 1, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; pH dependence: Optimum pH is 9.6 (isoform 2). {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720};
UniProtKB/Swiss-Prot CatalyticActivity: ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1).
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by 10 mM sodium bicarbonate.
UniProtKB/Swiss-Prot Function: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstitued reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates.

Enzyme Numbers (IUBMB) for FPGS Gene

Gene Ontology (GO) - Molecular Function for FPGS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004326 tetrahydrofolylpolyglutamate synthase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity --
genes like me logo Genes that share ontologies with FPGS: view

Phenotypes for FPGS Gene

genes like me logo Genes that share phenotypes with FPGS: view

Animal Model Products

CRISPR Products

miRNA for FPGS Gene

miRTarBase miRNAs that target FPGS

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for FPGS Gene

Localization for FPGS Gene

Subcellular locations from UniProtKB/Swiss-Prot for FPGS Gene

Isoform 1: Mitochondrion inner membrane. Mitochondrion matrix.
Isoform 2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FPGS Gene COMPARTMENTS Subcellular localization image for FPGS gene
Compartment Confidence
mitochondrion 5
cytosol 4
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FPGS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 1409616
GO:0005739 mitochondrion TAS 7721888
GO:0005743 mitochondrial inner membrane IEA --
GO:0005759 mitochondrial matrix TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FPGS: view

Pathways for FPGS Gene

SuperPathways for FPGS Gene

Superpath Contained pathways
1 Defective BTD causes biotidinase deficiency
2 Metabolism
3 Pyrimidine metabolism
4 Disease
5 Folate biosynthesis
genes like me logo Genes that share pathways with FPGS: view

UniProtKB/Swiss-Prot Q05932-FOLC_HUMAN

  • Pathway: Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis

Gene Ontology (GO) - Biological Process for FPGS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0006139 nucleobase-containing compound metabolic process TAS 7721888
GO:0006730 one-carbon metabolic process IEA --
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
genes like me logo Genes that share ontologies with FPGS: view

Compounds for FPGS Gene

(10) HMDB Compounds for FPGS Gene

Compound Synonyms Cas Number PubMed IDs
7,8-Dihydropteroic acid
  • 4-[[(2-amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]-Benzoic acid
2134-76-1
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Dihydrofolic acid
  • 7,8-Dihydro-L-folic acid
4033-27-6
Famotidine
  • Amfamox
76824-35-6

(4) Drugbank Compounds for FPGS Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Glutamic Acid
  • (2S)-2-Aminopentanedioic acid
56-86-0 target
Methotrexate
  • Amethopterin
59-05-2 enzyme substrate
Pralatrexate
146464-95-1 enzyme substrate
Raltitrexed
  • ZD-1694
112887-68-0 target antagonist

(47) Novoseek inferred chemical compound relationships for FPGS Gene

Compound -log(P) Hits PubMed IDs
lometrexol 93.5 9
glycinamide ribonucleotide 93.2 7
tomudex 93.2 21
1843u89 93.1 6
thymidylate 92.2 33

(2) PharmGKB related drug/compound annotations for FPGS Gene

Drug/compound Annotation
methotrexate CA
warfarin CA
genes like me logo Genes that share compounds with FPGS: view

Transcripts for FPGS Gene

Unigene Clusters for FPGS Gene

Folylpolyglutamate synthase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FPGS

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FPGS
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FPGS Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14 ^
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - -
SP6: -
SP7: - -
SP8: - - - - -
SP9: - -
SP10: - -
SP11: -
SP12: - -
SP13: - - - - -
SP14: - -
SP15:

ExUns: 15 ^ 16a · 16b ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for FPGS Gene

GeneLoc Exon Structure for
FPGS
ECgene alternative splicing isoforms for
FPGS

Expression for FPGS Gene

mRNA expression in normal human tissues for FPGS Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FPGS Gene

SOURCE GeneReport for Unigene cluster for FPGS Gene Hs.335084

genes like me logo Genes that share expressions with FPGS: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FPGS Gene

Orthologs for FPGS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FPGS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FPGS 35
  • 96.49 (n)
  • 96.42 (a)
FPGS 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FPGS 35
  • 86.93 (n)
  • 85.27 (a)
FPGS 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FPGS 35
  • 86.66 (n)
  • 86.88 (a)
FPGS 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fpgs 35
  • 82.51 (n)
  • 82.11 (a)
Fpgs 16
Fpgs 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FPGS 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fpgs 35
  • 80.75 (n)
  • 80.92 (a)
chicken
(Gallus gallus)
Aves FPGS 35
  • 71 (n)
  • 69.48 (a)
FPGS 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FPGS 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fpgs 35
  • 66.42 (n)
  • 68.69 (a)
zebrafish
(Danio rerio)
Actinopterygii fpgs 35
  • 63.43 (n)
  • 64.11 (a)
fpgs 36
  • 60 (a)
OneToOne
wufk51d09 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004679 35
  • 47.55 (n)
  • 41.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2543 35
  • 54.03 (n)
  • 46.23 (a)
CG2543 36
  • 33 (a)
OneToMany
CG31773 36
  • 20 (a)
OneToMany
CG2543 37
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea F25B5.6 35
  • 47.07 (n)
  • 43.38 (a)
F25B5.6 36
  • 38 (a)
OneToOne
F25B5.6b 37
  • 36 (a)
F25B5.6a 37
  • 36 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR134W 35
  • 54.97 (n)
  • 46.93 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MET7 35
  • 47.75 (n)
  • 45.89 (a)
MET7 36
  • 36 (a)
OneToOne
MET7 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F11297g 35
  • 47.31 (n)
  • 46.94 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons DFB 35
  • 49.82 (n)
  • 45.82 (a)
rice
(Oryza sativa)
Liliopsida Os03g0111100 35
  • 50 (n)
  • 44.54 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00892 35
  • 50.99 (n)
  • 44.19 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1709.17 35
  • 45.97 (n)
  • 43.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
CSA.8819 36
  • 50 (a)
OneToMany
Species with no ortholog for FPGS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FPGS Gene

ENSEMBL:
Gene Tree for FPGS (if available)
TreeFam:
Gene Tree for FPGS (if available)

Paralogs for FPGS Gene

No data available for Paralogs for FPGS Gene

Variants for FPGS Gene

Sequence variations from dbSNP and Humsavar for FPGS Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs10106 -- 127,813,796(-) AGCCA(A/G)GAGGA utr-variant-3-prime, nc-transcript-variant, intron-variant
rs955171 -- 127,803,528(+) AATCA(G/T)GGGTA intron-variant
rs1042304 -- 127,813,808(+) AGATA(A/G)CAGAG utr-variant-3-prime, nc-transcript-variant, intron-variant
rs1042320 -- 127,813,979(+) GCCTT(C/T)TGGGA utr-variant-3-prime, nc-transcript-variant, intron-variant
rs1966227 -- 127,805,108(-) agttc(A/G)agaac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FPGS Gene

Variant ID Type Subtype PubMed ID
nsv893859 CNV Loss 21882294
nsv893860 CNV Gain 21882294
nsv893865 CNV Loss 21882294
nsv893868 CNV Loss 21882294
dgv8287n71 CNV Loss 21882294
nsv471323 CNV Loss 18288195
dgv8288n71 CNV Loss 21882294
nsv466575 CNV Loss 19166990
nsv893874 CNV Loss 21882294
nsv466576 CNV Loss 19166990

Relevant External Links for FPGS Gene

HapMap Linkage Disequilibrium report
FPGS
Human Gene Mutation Database (HGMD)
FPGS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FPGS Gene

Disorders for FPGS Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for FPGS Gene including...

Search for FPGS Gene in MalaCards »

(26) Novoseek inferred disease relationships for FPGS Gene

Disease -log(P) Hits PubMed IDs
leukemia 58.3 25
folate deficiency 50.9 4
lymphoblastic leukemia acute 48.4 7
t-all 47.6 8
colorectal cancer 46.9 4

Relevant External Links for FPGS

Genetic Association Database (GAD)
FPGS
Human Genome Epidemiology (HuGE) Navigator
FPGS
genes like me logo Genes that share disorders with FPGS: view

No data available for UniProtKB/Swiss-Prot for FPGS Gene

Publications for FPGS Gene

  1. Expression cloning of a human cDNA encoding folylpoly(gamma- glutamate) synthetase and determination of its primary structure. (PMID: 1409616) Garrow T.A. … Shane B. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 4 23
  2. Upstream organization of and multiple transcripts from the human folylpoly-gamma-glutamate synthetase gene. (PMID: 7721888) Freemantle S.J. … Moran R.G. (J. Biol. Chem. 1995) 3 4 23
  3. Purification and properties of human cytosolic folylpoly-gamma- glutamate synthetase and organization, localization, and differential splicing of its gene. (PMID: 8662720) Chen L. … Shane B. (J. Biol. Chem. 1996) 3 4 23
  4. Submitochondrial localization of the mitochondrial isoform of folylpolyglutamate synthetase in CCRF-CEM human T-lymphoblastic leukemia cells. (PMID: 16169100) Nair J.R. … McGuire J.J. (Biochim. Biophys. Acta 2005) 3 4 23
  5. Exploratory analysis of four polymorphisms in human GGH and FPGS genes and their effect in methotrexate-treated rheumatoid arthritis patients. (PMID: 17286537) van der Straaten R.J. … Guchelaar H.J. (Pharmacogenomics 2007) 3 23 48

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