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Aliases for FPGS Gene

Aliases for FPGS Gene

  • Folylpolyglutamate Synthase 2 3 5
  • EC 6.3.2.17 4 61
  • Tetrahydrofolylpolyglutamate Synthase 4
  • Folylpoly-Gamma-Glutamate Synthetase 4
  • Tetrahydrofolate Synthase 4

External Ids for FPGS Gene

Previous GeneCards Identifiers for FPGS Gene

  • GC09P121679
  • GC09P122211
  • GC09P124018
  • GC09P125941
  • GC09P127644
  • GC09P129604
  • GC09P130556
  • GC09P100181

Summaries for FPGS Gene

Entrez Gene Summary for FPGS Gene

  • This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]

GeneCards Summary for FPGS Gene

FPGS (Folylpolyglutamate Synthase) is a Protein Coding gene. Diseases associated with FPGS include Retroperitoneal Liposarcoma and Borna Disease. Among its related pathways are One carbon pool by folate and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include ligase activity and tetrahydrofolylpolyglutamate synthase activity.

UniProtKB/Swiss-Prot for FPGS Gene

  • Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates.

Gene Wiki entry for FPGS Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FPGS Gene

Genomics for FPGS Gene

Regulatory Elements for FPGS Gene

Enhancers for FPGS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G127761 1.9 FANTOM5 Ensembl ENCODE dbSUPER 23.2 -27.8 -27764 11.3 HDGF PKNOX1 MLX ARNT SIN3A ARID4B DMAP1 ZBTB7B YY1 ZNF143 FPGS ENG SH2D3C LOC102723566 AK1 ST6GALNAC6 ST6GALNAC4 PIP5KL1 FAM129B SWI5
GH09G127826 2 FANTOM5 Ensembl ENCODE dbSUPER 21.8 +33.6 33611 3.7 HDGF CREB3L1 AGO1 ARID4B YY1 SLC30A9 REST ZNF592 KAT8 MEF2D FPGS ENG FAM129B AK1 ST6GALNAC6 ST6GALNAC4 PIP5KL1 CDK9 ENSG00000227218 TOR2A
GH09G127860 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.4 +67.3 67322 3.7 HDGF PKNOX1 MLX CREB3L1 ARNT ZNF766 ZNF263 MEF2D SREBF1 SMARCA4 ST6GALNAC6 LOC102723566 FPGS PTRH1 TTC16 CDK9 TOR2A FAM129B CERCAM ODF2
GH09G127800 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +8.1 8092 4.5 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ENG CDK9 SLC2A8 PTRH1 FPGS LOC101929270 LOC102723566 ENSG00000227218 URM1 FAM129B
GH09G127775 1.7 FANTOM5 ENCODE dbSUPER 11.3 -11.7 -11698 13.9 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ZFP64 ARID4B SIN3A DMAP1 CDK9 ZBTB34 FPGS PTRH1 LOC101929270 SH2D3C LOC102723566 TOR2A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FPGS on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the FPGS gene promoter:

Genomic Location for FPGS Gene

Chromosome:
9
Start:
127,794,597 bp from pter
End:
127,814,520 bp from pter
Size:
19,924 bases
Orientation:
Plus strand

Genomic View for FPGS Gene

Genes around FPGS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FPGS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FPGS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FPGS Gene

Proteins for FPGS Gene

  • Protein details for FPGS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05932-FOLC_HUMAN
    Recommended name:
    Folylpolyglutamate synthase, mitochondrial
    Protein Accession:
    Q05932
    Secondary Accessions:
    • B3KPW4
    • B7Z2Z3
    • F5H0K6
    • Q5JU19
    • Q5JU22
    • Q6P2P6

    Protein attributes for FPGS Gene

    Size:
    587 amino acids
    Molecular mass:
    64609 Da
    Cofactor:
    Name=K(+); Xref=ChEBI:CHEBI:29103; Name=NH4(+); Xref=ChEBI:CHEBI:28938;
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAA35852.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FPGS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FPGS Gene

Selected DME Specific Peptides for FPGS Gene

Q05932:
  • EKIAWQKGGIFK
  • NADQQNFTVTLDQVLLRCL
  • YFRFLTLMA
  • VLVTGSLHLVGGVL
  • DHTSLLG

Post-translational modifications for FPGS Gene

  • Ubiquitination at isoforms=2, 3, 466, Lys107, isoforms=2, 3, 4124, isoforms=2, 3, 4154, and isoforms=2, 3, 4248
  • Modification sites at PhosphoSitePlus

Domains & Families for FPGS Gene

Graphical View of Domain Structure for InterPro Entry

Q05932

UniProtKB/Swiss-Prot:

FOLC_HUMAN :
  • Belongs to the folylpolyglutamate synthase family.
Family:
  • Belongs to the folylpolyglutamate synthase family.
genes like me logo Genes that share domains with FPGS: view

No data available for Gene Families for FPGS Gene

Function for FPGS Gene

Molecular function for FPGS Gene

GENATLAS Biochemistry:
folylpoly-gamma-glutamate synthase
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=201 uM for L-glutamate (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=200 uM for MgATP (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=59 uM for pteroylglutamic acid (PteGlu) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=16 uM for PteGlu(2) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=20 uM for PteGlu(3) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=12 uM for PteGlu(4) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=64 uM for PteGlu(5) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=0.81 uM for H(2)PteGlu (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=47 uM for H(2)PteGlu(2) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=1.6 uM for (6ambo)-tetrahydropteroylpoly-gamma-glutamate (H(4)PteGlu) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=4.4 uM for (6S)-H(4)PteGlu (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=3.3 uM for (6S)-H(4)PteGlu(2) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=1.4 uM for (6S)-H(4)PteGlu(3) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=1.6 uM for (6S)-H(4)PteGlu(4) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=1.4 uM for (6S)-H(4)PteGlu(5) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=3.7 uM for (6R)-10-formyl-H(4)PteGlu (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=2.7 uM for (6R)-10-formyl-H(4)PteGlu(2) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=105 uM for (6S)-5-formyl-H(4)PteGlu (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=13 uM for (6S)-5-formyl-H(4)PteGlu(2) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=48 uM for (6S)-5-methyl-H(4)PteGlu (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=4.4 uM for aminopterin (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=55.5 uM for methotrexate (isoform 2, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=52.6 uM for methotrexate (isoform 1, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=71 uM for methotrexate (Glu-1) (isoform 2, PubMed:8662720, at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=50 uM for methotrexate (Glu-2) (isoform 2, PubMed:8662720, at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=148 uM for methotrexate (Glu-3) (isoform 2, PubMed:8662720, at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=5.3 uM for 5-deazaacyclotetrahydrofolate (isoform 2, at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=2.8 uM for 2-methyl-5,8-dideazaisofolate (isoform 2, at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=1702 uM for glutamic acid (isoform 2, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=2068 uM for glutamic acid (isoform 1, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; Vmax=0.34 umol/h/mg enzyme with methotrexate as substrate (isoform 2, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; Vmax=0.05 umol/h/mg enzyme with methotrexate as substrate (isoform 1, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; Vmax=1.26 umol/h/mg enzyme with glutamic acid as substrate (isoform 2, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; Vmax=0.25 umol/h/mg enzyme with glutamic acid as substrate (isoform 1, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; pH dependence: Optimum pH is 9.6 (isoform 2). {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1).
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by 10 mM sodium bicarbonate.
UniProtKB/Swiss-Prot Function:
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates.

Enzyme Numbers (IUBMB) for FPGS Gene

Gene Ontology (GO) - Molecular Function for FPGS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004326 tetrahydrofolylpolyglutamate synthase activity TAS,IEA --
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FPGS: view
genes like me logo Genes that share phenotypes with FPGS: view

Animal Models for FPGS Gene

MGI Knock Outs for FPGS:
  • Fpgs tm1a(EUCOMM)Hmgu

Animal Model Products

  • Taconic Biosciences Mouse Models for FPGS

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FPGS Gene

Localization for FPGS Gene

Subcellular locations from UniProtKB/Swiss-Prot for FPGS Gene

Isoform 1: Mitochondrion inner membrane. Mitochondrion matrix.
Isoform 2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FPGS gene
Compartment Confidence
mitochondrion 5
cytosol 5
lysosome 1

Gene Ontology (GO) - Cellular Components for FPGS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 1409616
GO:0005739 mitochondrion TAS 7721888
GO:0005743 mitochondrial inner membrane IEA --
GO:0005759 mitochondrial matrix TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FPGS: view

Pathways & Interactions for FPGS Gene

genes like me logo Genes that share pathways with FPGS: view

UniProtKB/Swiss-Prot Q05932-FOLC_HUMAN

  • Pathway: Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.

Gene Ontology (GO) - Biological Process for FPGS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0006139 nucleobase-containing compound metabolic process TAS 7721888
GO:0006536 glutamate metabolic process IDA 3619447
GO:0006730 one-carbon metabolic process IEA --
GO:0006760 folic acid-containing compound metabolic process IDA 3619447
genes like me logo Genes that share ontologies with FPGS: view

No data available for SIGNOR curated interactions for FPGS Gene

Drugs & Compounds for FPGS Gene

(29) Drugs for FPGS Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methotrexate Approved Pharma Enzyme, substrate Folate antagonist,inhibits DFHR 1551
Raltitrexed Approved, Investigational Pharma Target, antagonist 33
Pralatrexate Approved Pharma Enzyme, substrate Antifolate,a folate analog, RFC-1 targeted DHFR inhibitor 0
Warfarin Approved Pharma 470
Folotyn Approved September 2009 Pharma 0

(33) Additional Compounds for FPGS Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
7,8-Dihydropteroic acid
  • 4-[[(2-Amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]-Benzoate
  • 4-[[(2-Amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]-Benzoic acid
  • 4-[[(2-Amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]-Benzoate
  • 4-[[(2-Amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]-Benzoic acid
  • 7,8-Dihydropteroate
2134-76-1
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
Tetrahydrofolyl-[Glu](2)
  • Tetrahydrofolyl-[Glu](2)
  • Tetrahydrofolyl-[Glu](N+1)
  • Tetrahydropteroyl-[gamma-Glu]N
  • Tetrahydropteroyl-[gamma-Glu]N+1
  • THF-L-glutamate
Tetrahydrofolyl-[Glu](n)
  • Tetrahydrofolyl-[Glu](N+1)
  • Tetrahydropteroyl-[gamma-Glu]N
  • Tetrahydropteroyl-[gamma-Glu]N+1
  • THF-L-Glutamic acid
  • THF-polyglutamate
genes like me logo Genes that share compounds with FPGS: view

Transcripts for FPGS Gene

Unigene Clusters for FPGS Gene

Folylpolyglutamate synthase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FPGS Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14 ^
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - -
SP6: -
SP7: - -
SP8: - - - - -
SP9: - -
SP10: - -
SP11: -
SP12: - -
SP13: - - - - -
SP14: - -
SP15:

ExUns: 15 ^ 16a · 16b ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for FPGS Gene

GeneLoc Exon Structure for
FPGS
ECgene alternative splicing isoforms for
FPGS

Expression for FPGS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FPGS Gene

Protein differential expression in normal tissues from HIPED for FPGS Gene

This gene is overexpressed in Adrenal (12.2), Lymph node (12.2), Platelet (12.1), Liver (9.9), Ovary (8.9), and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FPGS Gene



NURSA nuclear receptor signaling pathways regulating expression of FPGS Gene:

FPGS

SOURCE GeneReport for Unigene cluster for FPGS Gene:

Hs.335084

Evidence on tissue expression from TISSUES for FPGS Gene

  • Lung(4.4)
  • Blood(4.2)
  • Nervous system(2.8)
  • Intestine(2.2)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with FPGS: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FPGS Gene

Orthologs for FPGS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FPGS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FPGS 34 35
  • 96.49 (n)
cow
(Bos Taurus)
Mammalia FPGS 34 35
  • 86.93 (n)
dog
(Canis familiaris)
Mammalia FPGS 34 35
  • 86.66 (n)
mouse
(Mus musculus)
Mammalia Fpgs 34 16 35
  • 82.51 (n)
rat
(Rattus norvegicus)
Mammalia Fpgs 34
  • 80.75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 70 (a)
OneToMany
-- 35
  • 68 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia FPGS 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves FPGS 34 35
  • 71 (n)
lizard
(Anolis carolinensis)
Reptilia FPGS 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fpgs 34
  • 66.42 (n)
zebrafish
(Danio rerio)
Actinopterygii fpgs 34 35
  • 63.43 (n)
wufk51d09 34
fruit fly
(Drosophila melanogaster)
Insecta CG2543 36 34 35
  • 54.03 (n)
CG31773 35
  • 20 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004679 34
  • 47.55 (n)
worm
(Caenorhabditis elegans)
Secernentea F25B5.6 34 35
  • 47.07 (n)
F25B5.6a 36
  • 36 (a)
F25B5.6b 36
  • 36 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR134W 34
  • 54.97 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MET7 34 35 37
  • 47.75 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F11297g 34
  • 47.31 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons DFB 34
  • 49.82 (n)
rice
(Oryza sativa)
Liliopsida Os03g0111100 34
  • 50 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00892 34
  • 50.99 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8819 35
  • 50 (a)
OneToMany
-- 35
  • 43 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1709.17 34
  • 45.97 (n)
Species where no ortholog for FPGS was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FPGS Gene

ENSEMBL:
Gene Tree for FPGS (if available)
TreeFam:
Gene Tree for FPGS (if available)

Paralogs for FPGS Gene

No data available for Paralogs for FPGS Gene

Variants for FPGS Gene

Sequence variations from dbSNP and Humsavar for FPGS Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000259164 -- 127,803,896(+) AATTC(C/G)AATAC intron-variant, upstream-variant-2KB
rs1000280267 -- 127,812,725(+) TTTCA(C/G)CATGT intron-variant
rs1000900482 -- 127,813,821(+) GCTCC(C/T)CGGGT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1001014419 -- 127,802,630(+) AGGTT(C/G)GTGAC upstream-variant-2KB
rs1001045385 -- 127,802,903(+) TAGAG(C/G)GCTGC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FPGS Gene

Variant ID Type Subtype PubMed ID
dgv12879n54 CNV loss 21841781
dgv12880n54 CNV loss 21841781
esv3891727 CNV gain 25118596
nsv466575 CNV loss 19166990
nsv466576 CNV loss 19166990
nsv471323 CNV loss 18288195
nsv615373 CNV loss 21841781
nsv615374 CNV loss 21841781

Variation tolerance for FPGS Gene

Residual Variation Intolerance Score: 64.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.23; 40.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FPGS Gene

Human Gene Mutation Database (HGMD)
FPGS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FPGS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FPGS Gene

Disorders for FPGS Gene

MalaCards: The human disease database

(5) MalaCards diseases for FPGS Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
retroperitoneal liposarcoma
  • giant pelvic retroperitoneal liposarcoma
borna disease
  • enzootic encephalomyelitis
pleural cancer
  • neoplasm of pleura
leukemia, acute lymphoblastic
  • leukemia, t-cell acute lymphocytic, somatic
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search FPGS in MalaCards View complete list of genes associated with diseases

Relevant External Links for FPGS

Genetic Association Database (GAD)
FPGS
Human Genome Epidemiology (HuGE) Navigator
FPGS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FPGS
genes like me logo Genes that share disorders with FPGS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FPGS Gene

Publications for FPGS Gene

  1. Phase II trial of pemetrexed plus bevacizumab for second-line therapy of patients with advanced non-small-cell lung cancer: NCCTG and SWOG study N0426. (PMID: 19841321) Adjei A.A. … Zinner R.G. (J. Clin. Oncol. 2010) 3 22 46 64
  2. Genes involved with folate uptake and distribution and their association with colorectal cancer risk. (PMID: 20037791) Figueiredo J.C. … Haile R.W. (Cancer Causes Control 2010) 3 22 46 64
  3. Outcomes of methotrexate therapy for psoriasis and relationship to genetic polymorphisms. (PMID: 19016697) Warren R.B. … Griffiths C.E. (Br. J. Dermatol. 2009) 3 22 46 64
  4. Concentration-dependent processivity of multiple glutamate ligations catalyzed by folylpoly-gamma-glutamate synthetase. (PMID: 18672898) Tomsho J.W. … Coward J.K. (Biochemistry 2008) 3 4 22 64
  5. Methotrexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis. (PMID: 18381794) Ranganathan P. … McLeod H.L. (J. Rheumatol. 2008) 3 22 46 64

Products for FPGS Gene

Sources for FPGS Gene

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