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Aliases for FPGS Gene

Aliases for FPGS Gene

  • Folylpolyglutamate Synthase 2 3 5
  • EC 6.3.2.17 4 63
  • Tetrahydrofolylpolyglutamate Synthase 4
  • Folylpoly-Gamma-Glutamate Synthetase 4
  • Tetrahydrofolate Synthase 4

External Ids for FPGS Gene

Previous GeneCards Identifiers for FPGS Gene

  • GC09P121679
  • GC09P122211
  • GC09P124018
  • GC09P125941
  • GC09P127644
  • GC09P129604
  • GC09P130556
  • GC09P100181

Summaries for FPGS Gene

Entrez Gene Summary for FPGS Gene

  • This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]

GeneCards Summary for FPGS Gene

FPGS (Folylpolyglutamate Synthase) is a Protein Coding gene. Diseases associated with FPGS include retroperitoneal liposarcoma and borna disease. Among its related pathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include ligase activity and tetrahydrofolylpolyglutamate synthase activity.

UniProtKB/Swiss-Prot for FPGS Gene

  • Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates.

Gene Wiki entry for FPGS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FPGS Gene

Genomics for FPGS Gene

Regulatory Elements for FPGS Gene

Transcription factor binding sites by QIAGEN in the FPGS gene promoter:

Genomic Location for FPGS Gene

Chromosome:
9
Start:
127,794,597 bp from pter
End:
127,814,520 bp from pter
Size:
19,924 bases
Orientation:
Plus strand

Genomic View for FPGS Gene

Genes around FPGS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FPGS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FPGS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FPGS Gene

Proteins for FPGS Gene

  • Protein details for FPGS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05932-FOLC_HUMAN
    Recommended name:
    Folylpolyglutamate synthase, mitochondrial
    Protein Accession:
    Q05932
    Secondary Accessions:
    • B3KPW4
    • B7Z2Z3
    • F5H0K6
    • Q5JU19
    • Q5JU22
    • Q6P2P6

    Protein attributes for FPGS Gene

    Size:
    587 amino acids
    Molecular mass:
    64609 Da
    Cofactor:
    Name=K(+); Xref=ChEBI:CHEBI:29103; Name=NH4(+); Xref=ChEBI:CHEBI:28938;
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAA35852.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FPGS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FPGS Gene

Proteomics data for FPGS Gene at MOPED

Selected DME Specific Peptides for FPGS Gene

Post-translational modifications for FPGS Gene

  • Ubiquitination at Lys 66, Lys 107, Lys 124, Lys 154, and Lys 248
  • Modification sites at PhosphoSitePlus

Domains & Families for FPGS Gene

Graphical View of Domain Structure for InterPro Entry

Q05932

UniProtKB/Swiss-Prot:

FOLC_HUMAN :
  • Belongs to the folylpolyglutamate synthase family.
Family:
  • Belongs to the folylpolyglutamate synthase family.
genes like me logo Genes that share domains with FPGS: view

No data available for Gene Families for FPGS Gene

Function for FPGS Gene

Molecular function for FPGS Gene

GENATLAS Biochemistry:
folylpoly-gamma-glutamate synthase
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=201 uM for L-glutamate (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=200 uM for MgATP (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=59 uM for pteroylglutamic acid (PteGlu) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=16 uM for PteGlu(2) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=20 uM for PteGlu(3) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=12 uM for PteGlu(4) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=64 uM for PteGlu(5) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=0.81 uM for H(2)PteGlu (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=47 uM for H(2)PteGlu(2) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=1.6 uM for (6ambo)-tetrahydropteroylpoly-gamma-glutamate (H(4)PteGlu) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=4.4 uM for (6S)-H(4)PteGlu (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=3.3 uM for (6S)-H(4)PteGlu(2) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=1.4 uM for (6S)-H(4)PteGlu(3) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=1.6 uM for (6S)-H(4)PteGlu(4) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=1.4 uM for (6S)-H(4)PteGlu(5) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=3.7 uM for (6R)-10-formyl-H(4)PteGlu (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=2.7 uM for (6R)-10-formyl-H(4)PteGlu(2) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=105 uM for (6S)-5-formyl-H(4)PteGlu (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=13 uM for (6S)-5-formyl-H(4)PteGlu(2) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=48 uM for (6S)-5-methyl-H(4)PteGlu (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=4.4 uM for aminopterin (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=55.5 uM for methotrexate (isoform 2, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=52.6 uM for methotrexate (isoform 1, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=71 uM for methotrexate (Glu-1) (isoform 2, PubMed:8662720, at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=50 uM for methotrexate (Glu-2) (isoform 2, PubMed:8662720, at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=148 uM for methotrexate (Glu-3) (isoform 2, PubMed:8662720, at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=5.3 uM for 5-deazaacyclotetrahydrofolate (isoform 2, at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=2.8 uM for 2-methyl-5,8-dideazaisofolate (isoform 2, at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L- glutamate) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=1702 uM for glutamic acid (isoform 2, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; KM=2068 uM for glutamic acid (isoform 1, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; Vmax=0.34 umol/h/mg enzyme with methotrexate as substrate (isoform 2, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; Vmax=0.05 umol/h/mg enzyme with methotrexate as substrate (isoform 1, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; Vmax=1.26 umol/h/mg enzyme with glutamic acid as substrate (isoform 2, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; Vmax=0.25 umol/h/mg enzyme with glutamic acid as substrate (isoform 1, PubMed:17875718, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720}; pH dependence: Optimum pH is 9.6 (isoform 2). {ECO:0000269 PubMed:17875718, ECO:0000269 PubMed:8662720};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1).
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by 10 mM sodium bicarbonate.
UniProtKB/Swiss-Prot Function:
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates.

Enzyme Numbers (IUBMB) for FPGS Gene

genes like me logo Genes that share phenotypes with FPGS: view

Animal Models for FPGS Gene

MGI Knock Outs for FPGS:
  • Fpgs tm1a(EUCOMM)Hmgu

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FPGS Gene

Localization for FPGS Gene

Subcellular locations from UniProtKB/Swiss-Prot for FPGS Gene

Isoform 1: Mitochondrion inner membrane. Mitochondrion matrix.
Isoform 2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FPGS Gene COMPARTMENTS Subcellular localization image for FPGS gene
Compartment Confidence
cytosol 5
mitochondrion 5
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FPGS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 1409616
genes like me logo Genes that share ontologies with FPGS: view

Pathways & Interactions for FPGS Gene

genes like me logo Genes that share pathways with FPGS: view

UniProtKB/Swiss-Prot Q05932-FOLC_HUMAN

  • Pathway: Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.

Gene Ontology (GO) - Biological Process for FPGS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0006139 nucleobase-containing compound metabolic process TAS 7721888
GO:0006730 one-carbon metabolic process IEA --
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
genes like me logo Genes that share ontologies with FPGS: view

No data available for SIGNOR curated interactions for FPGS Gene

Drugs & Compounds for FPGS Gene

(27) Drugs for FPGS Gene - From: Novoseek, HMDB, DrugBank, FDA Approved Drugs, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methotrexate Approved Pharma Enzyme, substrate Folate antagonist,inhibits DFHR, Cytotoxic agent 1444
Raltitrexed Approved, Investigational Pharma Target, antagonist 27
Pralatrexate Approved Pharma Enzyme, substrate Antifolate,a folate analog, RFC-1 targeted DHFR inhibitor 0
Folotyn Approved September 2009 Pharma 0
Famotidine Approved Pharma Histamine H2-receptor antagonist 57

(34) Additional Compounds for FPGS Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
7,8-Dihydropteroic acid
  • 4-[[(2-Amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]-Benzoate
  • 4-[[(2-Amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]-Benzoic acid
  • 4-[[(2-Amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]-Benzoate
  • 4-[[(2-Amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]-Benzoic acid
  • 7,8-Dihydropteroate
2134-76-1
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Tetrahydrofolyl-[Glu](2)
  • Tetrahydrofolyl-[Glu](2)
  • Tetrahydrofolyl-[Glu](N+1)
  • Tetrahydropteroyl-[gamma-Glu]N
  • Tetrahydropteroyl-[gamma-Glu]N+1
  • THF-L-glutamate
genes like me logo Genes that share compounds with FPGS: view

Transcripts for FPGS Gene

Unigene Clusters for FPGS Gene

Folylpolyglutamate synthase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FPGS Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14 ^
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - -
SP6: -
SP7: - -
SP8: - - - - -
SP9: - -
SP10: - -
SP11: -
SP12: - -
SP13: - - - - -
SP14: - -
SP15:

ExUns: 15 ^ 16a · 16b ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for FPGS Gene

GeneLoc Exon Structure for
FPGS
ECgene alternative splicing isoforms for
FPGS

Expression for FPGS Gene

mRNA expression in normal human tissues for FPGS Gene

Protein differential expression in normal tissues from HIPED for FPGS Gene

This gene is overexpressed in Adrenal (12.2), Lymph node (12.2), Platelet (12.1), Liver (9.9), Ovary (8.9), and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FPGS Gene



SOURCE GeneReport for Unigene cluster for FPGS Gene Hs.335084

genes like me logo Genes that share expression patterns with FPGS: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FPGS Gene

Orthologs for FPGS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FPGS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FPGS 35
  • 86.93 (n)
  • 85.27 (a)
FPGS 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FPGS 35
  • 86.66 (n)
  • 86.88 (a)
FPGS 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FPGS 35
  • 96.49 (n)
  • 96.42 (a)
FPGS 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fpgs 35
  • 80.75 (n)
  • 80.92 (a)
mouse
(Mus musculus)
Mammalia Fpgs 16
Fpgs 36
  • 82 (a)
OneToOne
Fpgs 35
  • 82.51 (n)
  • 82.11 (a)
oppossum
(Monodelphis domestica)
Mammalia FPGS 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
chicken
(Gallus gallus)
Aves FPGS 35
  • 71 (n)
  • 69.48 (a)
FPGS 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FPGS 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fpgs 35
  • 66.42 (n)
  • 68.69 (a)
zebrafish
(Danio rerio)
Actinopterygii fpgs 35
  • 63.43 (n)
  • 64.11 (a)
wufk51d09 35
fpgs 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2543 37
  • 40 (a)
CG2543 35
  • 54.03 (n)
  • 46.23 (a)
CG2543 36
  • 33 (a)
OneToMany
CG31773 36
  • 20 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004679 35
  • 47.55 (n)
  • 41.42 (a)
worm
(Caenorhabditis elegans)
Secernentea F25B5.6a 37
  • 36 (a)
F25B5.6b 37
  • 36 (a)
F25B5.6 35
  • 47.07 (n)
  • 43.38 (a)
F25B5.6 36
  • 38 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR134W 35
  • 54.97 (n)
  • 46.93 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F11297g 35
  • 47.31 (n)
  • 46.94 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MET7 35
  • 47.75 (n)
  • 45.89 (a)
MET7 36
  • 36 (a)
OneToOne
MET7 38
thale cress
(Arabidopsis thaliana)
eudicotyledons DFB 35
  • 49.82 (n)
  • 45.82 (a)
rice
(Oryza sativa)
Liliopsida Os03g0111100 35
  • 50 (n)
  • 44.54 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00892 35
  • 50.99 (n)
  • 44.19 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1709.17 35
  • 45.97 (n)
  • 43.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
CSA.8819 36
  • 50 (a)
OneToMany
Species with no ortholog for FPGS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FPGS Gene

ENSEMBL:
Gene Tree for FPGS (if available)
TreeFam:
Gene Tree for FPGS (if available)

Paralogs for FPGS Gene

No data available for Paralogs for FPGS Gene

Variants for FPGS Gene

Sequence variations from dbSNP and Humsavar for FPGS Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs12686275 - 127,810,967(+) TGCCG(A/T)CTTCT nc-transcript-variant, reference, missense
rs17855900 - 127,813,306(+) GAGTG(C/T)CCCCA nc-transcript-variant, reference, missense
rs34354111 - 127,813,423(+) GATCA(C/G)CCAAG intron-variant, nc-transcript-variant, reference, missense
rs10760502 - 127,802,988(+) GCGGC(A/G)TAACG nc-transcript-variant, upstream-variant-2KB, reference, missense
VAR_066016 -

Structural Variations from Database of Genomic Variants (DGV) for FPGS Gene

Variant ID Type Subtype PubMed ID
nsv893859 CNV Loss 21882294
nsv893860 CNV Gain 21882294
nsv893865 CNV Loss 21882294
nsv893868 CNV Loss 21882294
dgv8287n71 CNV Loss 21882294
nsv471323 CNV Loss 18288195
dgv8288n71 CNV Loss 21882294
nsv466575 CNV Loss 19166990
nsv893874 CNV Loss 21882294
nsv466576 CNV Loss 19166990

Variation tolerance for FPGS Gene

Residual Variation Intolerance Score: 64.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.23; 40.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FPGS Gene

HapMap Linkage Disequilibrium report
FPGS
Human Gene Mutation Database (HGMD)
FPGS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FPGS Gene

Disorders for FPGS Gene

MalaCards: The human disease database

(4) MalaCards diseases for FPGS Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
retroperitoneal liposarcoma
  • giant pelvic retroperitoneal liposarcoma
borna disease
  • enzootic encephalomyelitis
colorectal cancer
  • colorectal cancer, somatic
leukemia, acute lymphoblastic
  • leukemia, t-cell acute lymphocytic, somatic
- elite association - COSMIC cancer census association via MalaCards
Search FPGS in MalaCards View complete list of genes associated with diseases

Relevant External Links for FPGS

Genetic Association Database (GAD)
FPGS
Human Genome Epidemiology (HuGE) Navigator
FPGS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FPGS
genes like me logo Genes that share disorders with FPGS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FPGS Gene

Publications for FPGS Gene

  1. Identification and characterization of genetic variation in the folylpolyglutamate synthase gene. (PMID: 17875718) Leil T.A. … Adjei A.A. (Cancer Res. 2007) 3 4 23 67
  2. Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase. (PMID: 16686541) DeMartino J.K. … Boger D.L. (J. Med. Chem. 2006) 23 25 26
  3. Synthesis and evaluation of a classical 2,4-diamino-5-substituted-furo[2,3-d]pyrimidine and a 2-amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidine as antifolates. (PMID: 16990006) Gangjee A. … Kisliuk R.L. (Bioorg. Med. Chem. 2006) 23 25 26
  4. Molecular determinants of folate levels after leucovorin administration in colorectal cancer. (PMID: 19636555) Sadahiro S. … Oka T. (Cancer Chemother. Pharmacol. 2010) 3 23
  5. Phase II trial of pemetrexed plus bevacizumab for second-line therapy of patients with advanced non-small-cell lung cancer: NCCTG and SWOG study N0426. (PMID: 19841321) Adjei A.A. … Zinner R.G. (J. Clin. Oncol. 2010) 3 23

Products for FPGS Gene

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