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Aliases for FOXS1 Gene

Aliases for FOXS1 Gene

  • Forkhead Box S1 2 3 5
  • Forkhead-Related Transcription Factor 10 3 4
  • Forkhead-Like 18 Protein 3 4
  • FREAC-10 3 4
  • FREAC10 3 4
  • FKHL18 3 4
  • Forkhead-Related Transcription Factor FREAC-10 3
  • Forkhead (Drosophila)-Like 18 2
  • Forkhead-Like 18 (Drosophila) 2
  • Forkhead-Related Activator 10 3

External Ids for FOXS1 Gene

Previous HGNC Symbols for FOXS1 Gene

  • FKHL18

Previous GeneCards Identifiers for FOXS1 Gene

  • GC20M029896
  • GC20M030432
  • GC20M027221

Summaries for FOXS1 Gene

Entrez Gene Summary for FOXS1 Gene

  • The forkhead family of transcription factors belongs to the winged helix class of DNA-binding proteins. The protein encoded by this intronless gene contains a forkhead domain and is found predominantly in aorta and kidney. The function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXS1 Gene

FOXS1 (Forkhead Box S1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXE3.

UniProtKB/Swiss-Prot for FOXS1 Gene

  • Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXS1 Gene

Genomics for FOXS1 Gene

Regulatory Elements for FOXS1 Gene

Genomic Location for FOXS1 Gene

Chromosome:
20
Start:
31,844,300 bp from pter
End:
31,845,619 bp from pter
Size:
1,320 bases
Orientation:
Minus strand

Genomic View for FOXS1 Gene

Genes around FOXS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXS1 Gene

Proteins for FOXS1 Gene

  • Protein details for FOXS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43638-FOXS1_HUMAN
    Recommended name:
    Forkhead box protein S1
    Protein Accession:
    O43638
    Secondary Accessions:
    • Q96D28

    Protein attributes for FOXS1 Gene

    Size:
    330 amino acids
    Molecular mass:
    35434 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXS1 Gene

Proteomics data for FOXS1 Gene at MOPED

Post-translational modifications for FOXS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXS1 Gene

Domains & Families for FOXS1 Gene

Gene Families for FOXS1 Gene

Protein Domains for FOXS1 Gene

Suggested Antigen Peptide Sequences for FOXS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43638

UniProtKB/Swiss-Prot:

FOXS1_HUMAN :
  • Contains 1 fork-head DNA-binding domain.
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXS1: view

Function for FOXS1 Gene

Molecular function for FOXS1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature (By similarity).

Gene Ontology (GO) - Molecular Function for FOXS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with FOXS1: view
genes like me logo Genes that share phenotypes with FOXS1: view

Animal Models for FOXS1 Gene

MGI Knock Outs for FOXS1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FOXS1 Gene

Localization for FOXS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXS1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXS1 Gene COMPARTMENTS Subcellular localization image for FOXS1 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for FOXS1 Gene

Pathways & Interactions for FOXS1 Gene

SuperPathways for FOXS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0009653 anatomical structure morphogenesis IBA --
GO:0030154 cell differentiation IBA --
GO:0040018 positive regulation of multicellular organism growth IEA --
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity IEA,ISS --
genes like me logo Genes that share ontologies with FOXS1: view

No data available for Pathways by source and SIGNOR curated interactions for FOXS1 Gene

Drugs & Compounds for FOXS1 Gene

No Compound Related Data Available

Transcripts for FOXS1 Gene

mRNA/cDNA for FOXS1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(31) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXS1 Gene

Forkhead box S1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXS1 Gene

No ASD Table

Relevant External Links for FOXS1 Gene

GeneLoc Exon Structure for
FOXS1
ECgene alternative splicing isoforms for
FOXS1

Expression for FOXS1 Gene

mRNA expression in normal human tissues for FOXS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXS1 Gene

This gene is overexpressed in Artery - Coronary (x10.6), Artery - Aorta (x8.3), and Artery - Tibial (x7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FOXS1 Gene



SOURCE GeneReport for Unigene cluster for FOXS1 Gene Hs.516971

genes like me logo Genes that share expression patterns with FOXS1: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FOXS1 Gene

Orthologs for FOXS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOXS1 35
  • 87.27 (n)
  • 84.85 (a)
FOXS1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXS1 35
  • 90.3 (n)
  • 89.7 (a)
mouse
(Mus musculus)
Mammalia Foxs1 35
  • 79.53 (n)
  • 75.68 (a)
Foxs1 16
Foxs1 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FOXS1 35
  • 99.39 (n)
  • 99.39 (a)
FOXS1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxs1 35
  • 79.82 (n)
  • 77.68 (a)
oppossum
(Monodelphis domestica)
Mammalia FOXS1 36
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOXS1 35
  • 64.25 (n)
  • 58.99 (a)
lizard
(Anolis carolinensis)
Reptilia FOXS1 36
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii foxc1b 36
  • 26 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta croc 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
ManyToMany
Species with no ortholog for FOXS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXS1 Gene

ENSEMBL:
Gene Tree for FOXS1 (if available)
TreeFam:
Gene Tree for FOXS1 (if available)

Paralogs for FOXS1 Gene

(11) SIMAP similar genes for FOXS1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXS1: view

Variants for FOXS1 Gene

Sequence variations from dbSNP and Humsavar for FOXS1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs2296917 - 31,844,669(+) AGTTG(C/G/T)CAGGG reference, missense
rs746388 -- 31,846,177(+) ACACA(C/G)ATATA upstream-variant-2KB
rs729186 -- 31,845,839(+) GGTGG(G/T)GGCTG upstream-variant-2KB
rs3939124 -- 31,846,475(+) gagag(A/G)ggaga upstream-variant-2KB
rs6089094 -- 31,843,968(+) GATCA(A/G)TGTCA downstream-variant-500B

Variation tolerance for FOXS1 Gene

Residual Variation Intolerance Score: 95.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.83; 47.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXS1 Gene

HapMap Linkage Disequilibrium report
FOXS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FOXS1 Gene

Disorders for FOXS1 Gene

Relevant External Links for FOXS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXS1

No disorders were found for FOXS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXS1 Gene

Publications for FOXS1 Gene

  1. Chromosome localization, sequence analysis, and expression pattern identify FKHL 18 as a novel human forkhead gene. (PMID: 9325056) Cederberg A. … Enerbaeck S. (Genomics 1997) 2 3 4 67
  2. Comparative genomics of vertebrate Fox cluster loci. (PMID: 17062144) Wotton K.R. … Shimeld S.M. (BMC Genomics 2006) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3

Products for FOXS1 Gene

Sources for FOXS1 Gene

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