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Aliases for FOXS1 Gene

Aliases for FOXS1 Gene

  • Forkhead Box S1 2 3 5
  • Forkhead-Related Transcription Factor 10 3 4
  • Forkhead-Like 18 Protein 3 4
  • FREAC-10 3 4
  • FREAC10 3 4
  • FKHL18 3 4
  • Forkhead-Related Transcription Factor FREAC-10 3
  • Forkhead (Drosophila)-Like 18 2
  • Forkhead-Like 18 (Drosophila) 2
  • Forkhead-Related Activator 10 3
  • Forkhead Box Protein S1 3

External Ids for FOXS1 Gene

Previous HGNC Symbols for FOXS1 Gene

  • FKHL18

Previous GeneCards Identifiers for FOXS1 Gene

  • GC20M029896
  • GC20M030432
  • GC20M027221

Summaries for FOXS1 Gene

Entrez Gene Summary for FOXS1 Gene

  • The forkhead family of transcription factors belongs to the winged helix class of DNA-binding proteins. The protein encoded by this intronless gene contains a forkhead domain and is found predominantly in aorta and kidney. The function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXS1 Gene

FOXS1 (Forkhead Box S1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXC1.

UniProtKB/Swiss-Prot for FOXS1 Gene

  • Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXS1 Gene

Genomics for FOXS1 Gene

Regulatory Elements for FOXS1 Gene

Enhancers for FOXS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G031860 1.2 Ensembl ENCODE 23.5 -15.9 -15932 2.6 HDGF PKNOX1 RB1 FUS ZNF76 KLF17 SIN3A GLIS2 ZNF366 ZNF207 FOXS1 DUSP15 MYLK2 TTLL9
GH20G031968 1.4 ENCODE dbSUPER 10.1 -122.9 -122934 0.2 MLX CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF766 ZNF143 C20orf203 TSPY26P RSL24D1P6 KIF3B FOXS1 XKR7 PDRG1
GH20G031879 1.1 ENCODE 8.9 -34.3 -34259 1.4 PKNOX1 FOXA2 ARNT CREB3L1 ARID4B SIN3A DMAP1 YBX1 YY1 SLC30A9 DUSP15 FOXS1 MYLK2 RNU1-94P
GH20G031808 0.2 dbSUPER 12 +36.8 36810 0.9 FOXS1 DUSP15 TTLL9 TPX2 RNA5SP481 CCM2L TM9SF4 HM13 ENSG00000230801 MYLK2
GH20G031852 1.1 Ensembl ENCODE 0.4 -7.3 -7344 0.7 ELF3 RB1 ARID4B KLF17 ZSCAN9 RAD21 RARA RFX5 ZNF143 ZNF207 MYLK2 FOXS1 TTLL9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FOXS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FOXS1 Gene

Chromosome:
20
Start:
31,844,300 bp from pter
End:
31,845,619 bp from pter
Size:
1,320 bases
Orientation:
Minus strand

Genomic View for FOXS1 Gene

Genes around FOXS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXS1 Gene

Proteins for FOXS1 Gene

  • Protein details for FOXS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43638-FOXS1_HUMAN
    Recommended name:
    Forkhead box protein S1
    Protein Accession:
    O43638
    Secondary Accessions:
    • Q96D28

    Protein attributes for FOXS1 Gene

    Size:
    330 amino acids
    Molecular mass:
    35434 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXS1 Gene

Post-translational modifications for FOXS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXS1 Gene

Domains & Families for FOXS1 Gene

Gene Families for FOXS1 Gene

Protein Domains for FOXS1 Gene

Suggested Antigen Peptide Sequences for FOXS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FOXS1: view

No data available for UniProtKB/Swiss-Prot for FOXS1 Gene

Function for FOXS1 Gene

Molecular function for FOXS1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature (By similarity).

Gene Ontology (GO) - Molecular Function for FOXS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003677 DNA binding ISS --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 9325056
genes like me logo Genes that share ontologies with FOXS1: view
genes like me logo Genes that share phenotypes with FOXS1: view

Animal Models for FOXS1 Gene

MGI Knock Outs for FOXS1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Cell Line Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FOXS1 Gene

Localization for FOXS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXS1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXS1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for FOXS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,IBA --
genes like me logo Genes that share ontologies with FOXS1: view

Pathways & Interactions for FOXS1 Gene

SuperPathways for FOXS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001568 blood vessel development ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with FOXS1: view

No data available for Pathways by source and SIGNOR curated interactions for FOXS1 Gene

Transcripts for FOXS1 Gene

mRNA/cDNA for FOXS1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(31) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXS1 Gene

Forkhead box S1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXS1 Gene

No ASD Table

Relevant External Links for FOXS1 Gene

GeneLoc Exon Structure for
FOXS1
ECgene alternative splicing isoforms for
FOXS1

Expression for FOXS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOXS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXS1 Gene

This gene is overexpressed in Artery - Coronary (x10.6), Artery - Aorta (x8.3), and Artery - Tibial (x7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FOXS1 Gene



NURSA nuclear receptor signaling pathways regulating expression of FOXS1 Gene:

FOXS1

SOURCE GeneReport for Unigene cluster for FOXS1 Gene:

Hs.516971

Evidence on tissue expression from TISSUES for FOXS1 Gene

  • Muscle(4.2)
genes like me logo Genes that share expression patterns with FOXS1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXS1 Gene

Orthologs for FOXS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXS1 34 35
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia FOXS1 34
  • 90.3 (n)
cow
(Bos Taurus)
Mammalia FOXS1 34 35
  • 87.27 (n)
rat
(Rattus norvegicus)
Mammalia Foxs1 34
  • 79.82 (n)
mouse
(Mus musculus)
Mammalia Foxs1 34 16 35
  • 79.53 (n)
oppossum
(Monodelphis domestica)
Mammalia FOXS1 35
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOXS1 34
  • 64.25 (n)
lizard
(Anolis carolinensis)
Reptilia FOXS1 35
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii foxc1b 35
  • 26 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta croc 35
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 20 (a)
ManyToMany
Species where no ortholog for FOXS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXS1 Gene

ENSEMBL:
Gene Tree for FOXS1 (if available)
TreeFam:
Gene Tree for FOXS1 (if available)

Paralogs for FOXS1 Gene

(11) SIMAP similar genes for FOXS1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXS1: view

Variants for FOXS1 Gene

Sequence variations from dbSNP and Humsavar for FOXS1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1002921569 -- 31,847,495(+) GATTT(C/T)TGTCC intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1003232111 -- 31,846,041(+) TCTCA(A/G)ACACT intron-variant, upstream-variant-2KB
rs1003255487 -- 31,846,278(+) AACAC(A/C)GAGAC intron-variant, upstream-variant-2KB
rs1003307837 -- 31,846,072(+) TACAC(A/G)TACAG intron-variant, upstream-variant-2KB
rs1003308306 -- 31,845,069(+) TCTGG(C/T)AGCTC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for FOXS1 Gene

Variant ID Type Subtype PubMed ID
dgv4300n100 CNV gain 25217958

Variation tolerance for FOXS1 Gene

Residual Variation Intolerance Score: 95.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.83; 47.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXS1 Gene

Disorders for FOXS1 Gene

Relevant External Links for FOXS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXS1

No disorders were found for FOXS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXS1 Gene

Publications for FOXS1 Gene

  1. Chromosome localization, sequence analysis, and expression pattern identify FKHL 18 as a novel human forkhead gene. (PMID: 9325056) Cederberg A. … Enerbaeck S. (Genomics 1997) 2 3 4 64
  2. Comparative genomics of vertebrate Fox cluster loci. (PMID: 17062144) Wotton K.R. … Shimeld S.M. (BMC Genomics 2006) 2 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64

Products for FOXS1 Gene

Sources for FOXS1 Gene

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