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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FOXRED2 Gene

protein-coding   GIFtS: 46
GCID: GC22M036883

FAD-Dependent Oxidoreductase Domain Containing 2

  Search for FOXRED2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
FAD-Dependent Oxidoreductase Domain Containing 21 2
Endoplasmic Reticulum Flavoprotein Associated With Degradation2 3
ERFAD2 3
FAD-Dependent Oxidoreductase Domain-Containing Protein 22

External Ids:    HGNC: 262641   Entrez Gene: 800202   Ensembl: ENSG000001003507   OMIM: 6137775   UniProtKB: Q8IWF23   

Export aliases for FOXRED2 gene to outside databases

Previous GC identifers: GC22M035214 GC22M019851


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FOXRED2 Gene: 
FOXRED2 (FAD-dependent oxidoreductase domain containing 2) is a protein-coding gene. GO annotations related to this gene include oxidoreductase activity and flavin adenine dinucleotide binding.

UniProtKB/Swiss-Prot: FXRD2_HUMAN, Q8IWF2
Function: Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May
bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for
subsequent degradation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FOXRED2 gene promoter:
         MZF-1   USF-1   Pax-2   STAT3   Pax-2a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOXRED2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FOXRED2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXRED2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.3   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q12.3

FOXRED2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXRED2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M036883:  view genomic region     (about GC identifiers)

Start:
36,883,233 bp from pter      End:
36,903,148 bp from pter
Size:
19,916 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FXRD2_HUMAN, Q8IWF2 (See protein sequence)
Recommended Name: FAD-dependent oxidoreductase domain-containing protein 2 precursor  
Size: 684 amino acids; 77791 Da
Cofactor: FAD
Subunit: Interacts with SEL1L. May interact with OS9 and DNAJC10
Subcellular location: Endoplasmic reticulum lumen
Secondary accessions: B2RDI4 Q8N378 Q96BD1 Q9H5L5 Q9H6M8
Alternative splicing: 2 isoforms:  Q8IWF2-1   Q8IWF2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FOXRED2: NX_Q8IWF2

Explore proteomics data for FOXRED2 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IWF2

  • FOXRED2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FOXRED2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001095841.1  NP_079231.4  

    ENSEMBL proteins: 
     ENSP00000380401   ENSP00000216187   ENSP00000382543   ENSP00000380400   ENSP00000409692  

    Human Recombinant Protein Products for FOXRED2: 
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    Cloud-Clone Corp. Proteins for FOXRED2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005788endoplasmic reticulum lumen IDA19706418

    FOXRED2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8IWF2

    UniProtKB/Swiss-Prot: FXRD2_HUMAN, Q8IWF2
    Similarity: Belongs to the FOXRED2 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FXRD2_HUMAN, Q8IWF2
    Function: Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May
    bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for
    subsequent degradation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19706418
    GO:0016491oxidoreductase activity IEA--
    GO:0050660flavin adenine dinucleotide binding IDA19706418
         
    FOXRED2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FOXRED2:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FOXRED2 
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    SwitchGear 3'UTR luciferase reporter plasmidFOXRED2 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOXRED2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/7 Interacting proteins for FOXRED2 (Q8IWF23 ENSP000002161874) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OS9Q134383, ENSP000003181654I2D: score=1 STRING: ENSP00000318165
    RPN1P048433, ENSP000002962554I2D: score=1 STRING: ENSP00000296255
    SEL1LQ9UBV23, ENSP000003370534I2D: score=1 STRING: ENSP00000337053
    DNAJC10Q8IXB13, ENSP000002640654I2D: score=1 STRING: ENSP00000264065
    KRTAP4-12Q9BQ663I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030433ER-associated protein catabolic process IMP19706418
    GO:0055114oxidation-reduction process ----

    FOXRED2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FOXRED2 (FXRD2)

    1 HMDB Compound for FOXRED2    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--

    Search CenterWatch for drugs/clinical trials and news about FOXRED2 / FXRD2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FOXRED2 gene (2 alternative transcripts): 
    NM_001102371.1  NM_024955.5  

    Unigene Cluster for FOXRED2:

    FAD-dependent oxidoreductase domain containing 2
    Hs.387601  [show with all ESTs]
    Unigene Representative Sequence: NM_024955
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397224(uc003apm.4 uc003apn.4 uc003apo.4 uc003app.4)
    ENST00000216187 ENST00000366463 ENST00000397223 ENST00000423980
    miRNA
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    hsa-miR-3200-5p hsa-miR-9 hsa-miR-182 hsa-miR-1271 hsa-miR-3175 hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidFOXRED2 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK025714.1 AK091053.1 AK225347.1 AK315555.1 BC015726.1 BC027716.2 BC040351.1 CR456444.1 

    17 DOTS entries:

    DT.100752508  DT.100808989  DT.97821073  DT.100038404  DT.100808991  DT.97843145  DT.100649803  DT.100754773 
    DT.100754777  DT.100802337  DT.430890  DT.100808981  DT.408568  DT.95212278  DT.99983135  DT.91860126 
    DT.92435426 

    24/536 AceView cDNA sequences (see all 536):

    BQ689796 BU174351 BQ691523 BM764705 NM_012473 BQ685876 BQ688422 AW515413 
    BX457676 F10516 AI694779 AA256427 BQ685154 BU166545 BM673497 BM917171 
    AI300901 BQ775191 BM477290 BQ880539 BQ687570 AI357994 CD672350 BU196797 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for FOXRED2 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d ^ 12
    SP1:                                                                                -                                             
    SP2:                                                        -     -                 -                                             
    SP3:                                                                                                  -                           
    SP4:        -     -                                                                                                               
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for FOXRED2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FOXRED2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGACGCACTC
    FOXRED2 Expression
    About this image


    See FOXRED2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FOXRED2

    SOURCE GeneReport for Unigene cluster: Hs.387601
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FOXRED2 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Foxred21 , 5 FAD-dependent oxidoreductase domain containing 21, 5 84.44(n)1
    84.94(a)1
      15 (36.92 cM)5
    2395541  NM_001017983.21  NP_001017983.21 
     779405225 
    chicken
    (Gallus gallus)
    Aves FOXRED21 FAD-dependent oxidoreductase domain containing 2 71.99(n)
    73.89(a)
      418054  XM_001234651.2  XP_001234652.1 
    lizard
    (Anolis carolinensis)
    Reptilia FOXRED26
    Uncharacterized protein
    69(a)
    1 ↔ 1
    5(22201461-22221690)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.144042 Transcribed sequences 73.38(n)    137731863 
    zebrafish
    (Danio rerio)
    Actinopterygii foxred21 FAD-dependent oxidoreductase domain containing 2 59.77(n)
    59.11(a)
      767722  NM_001076660.1  NP_001070128.1 


    ENSEMBL Gene Tree for FOXRED2 (if available)
    TreeFam Gene Tree for FOXRED2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/646 SNPs in FOXRED2 are shown (see all 646)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1163953851,2
    C,F--36882779(+) ACCTTA/GCTTGG 2 -- ds5001 int11Minor allele frequency- G:0.01WA 118
    rs1842464321,2
    --36882780(+) CCTTAC/GTTGGG 2 -- ds5001 int10--------
    rs734097661,2
    C,F--36882799(+) CATCTT/CGGGTC 2 -- ds5001 int12Minor allele frequency- C:0.21WA 120
    rs1119913311,2
    F--36882813(+) GTTAAG/ACTCAA 2 -- ds5001 int12Minor allele frequency- A:0.50CSA 4
    rs1504765881,2
    --36882870(+) GGAGGC/TTCCTT 2 -- ds5001 int10--------
    rs1454316511,2
    --36882901(+) CCCCCA/GGAATA 2 -- ds5001 int10--------
    rs1125890581,2
    F--36882958(+) GCTTGG/CTCTCT 2 -- ds5001 int11Minor allele frequency- C:0.50CSA 2
    rs1167770521,2
    F--36882979(+) TTGGTC/TGCTGT 2 -- ds5001 int11Minor allele frequency- T:0.01WA 118
    rs1816916111,2
    --36883020(+) CAGCCC/TGTTTC 2 -- ds5001 int10--------
    rs1433202811,2
    --36883030(+) CTTTCC/TGCCTT 2 -- ds5001 int10--------

    HapMap Linkage Disequilibrium report for FOXRED2 (36883233 - 36903148 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FOXRED2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv834186CNV Loss17160897
    nsv520497CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FOXRED2 for disorders           About MalaCards
    OMIM gene information: 613777    OMIM disorders: --


    FOXRED2 for disorders           About GeneDecksing


    Export disorders for FOXRED2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FOXRED2 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with FOXRED2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A luminal flavoprotein in endoplasmic reticulum-associated degradation. (PubMed id 19706418)1, 2 Riemer J.... Ellgaard L. (2009)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    6. Unassembled CD147 is an endogenous endoplasmic reticul um-associated degradation substrate. (PubMed id 23097496)1 Tyler R.E....Kopito R.R. (2012)
    7. Proteomic identification of common SCF ubiquitin ligas e FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (2012)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    10. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80020 HGNC: 26264 AceView: TXN2andFLJ23322 Ensembl:ENSG00000100350 euGenes: HUgn80020
    ECgene: FOXRED2 H-InvDB: FOXRED2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FOXRED2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FOXRED2 gene:
    Search GeneIP for patents involving FOXRED2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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