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Aliases for FOXRED2 Gene

Aliases for FOXRED2 Gene

  • FAD-Dependent Oxidoreductase Domain Containing 2 2 3
  • Endoplasmic Reticulum Flavoprotein Associated With Degradation 3 4
  • ERFAD 3 4

External Ids for FOXRED2 Gene

Previous GeneCards Identifiers for FOXRED2 Gene

  • GC22M035214
  • GC22M036883
  • GC22M019851

Summaries for FOXRED2 Gene

GeneCards Summary for FOXRED2 Gene

FOXRED2 (FAD-Dependent Oxidoreductase Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and glycoprotein binding.

UniProtKB/Swiss-Prot for FOXRED2 Gene

  • Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXRED2 Gene

Genomics for FOXRED2 Gene

Regulatory Elements for FOXRED2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FOXRED2 Gene

Chromosome:
22
Start:
36,487,186 bp from pter
End:
36,507,101 bp from pter
Size:
19,916 bases
Orientation:
Minus strand

Genomic View for FOXRED2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXRED2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXRED2 Gene

Proteins for FOXRED2 Gene

  • Protein details for FOXRED2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWF2-FXRD2_HUMAN
    Recommended name:
    FAD-dependent oxidoreductase domain-containing protein 2
    Protein Accession:
    Q8IWF2
    Secondary Accessions:
    • B2RDI4
    • Q8N378
    • Q96BD1
    • Q9H5L5
    • Q9H6M8

    Protein attributes for FOXRED2 Gene

    Size:
    684 amino acids
    Molecular mass:
    77791 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Interacts with SEL1L. May interact with OS9 and DNAJC10.

    Alternative splice isoforms for FOXRED2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXRED2 Gene

Proteomics data for FOXRED2 Gene at MOPED

Post-translational modifications for FOXRED2 Gene

Other Protein References for FOXRED2 Gene

Antibody Products

No data available for DME Specific Peptides for FOXRED2 Gene

Domains & Families for FOXRED2 Gene

Protein Domains for FOXRED2 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for FOXRED2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IWF2

UniProtKB/Swiss-Prot:

FXRD2_HUMAN :
  • Belongs to the FOXRED2 family.
Family:
  • Belongs to the FOXRED2 family.
genes like me logo Genes that share domains with FOXRED2: view

No data available for Gene Families for FOXRED2 Gene

Function for FOXRED2 Gene

Molecular function for FOXRED2 Gene

UniProtKB/Swiss-Prot Function:
Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation.

Gene Ontology (GO) - Molecular Function for FOXRED2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IPI 21359175
GO:0004497 monooxygenase activity IBA --
GO:0005515 protein binding IPI 19706418
GO:0050660 flavin adenine dinucleotide binding IDA 19706418
genes like me logo Genes that share ontologies with FOXRED2: view
genes like me logo Genes that share phenotypes with FOXRED2: view

Animal Model Products

CRISPR Products

miRNA for FOXRED2 Gene

miRTarBase miRNAs that target FOXRED2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOXRED2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FOXRED2 Gene

Localization for FOXRED2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXRED2 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXRED2 Gene COMPARTMENTS Subcellular localization image for FOXRED2 gene
Compartment Confidence
endoplasmic reticulum 5

Gene Ontology (GO) - Cellular Components for FOXRED2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen IDA 19706418
genes like me logo Genes that share ontologies with FOXRED2: view

Pathways & Interactions for FOXRED2 Gene

SuperPathways for FOXRED2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXRED2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IMP 19706418
GO:0055114 oxidation-reduction process IBA --
genes like me logo Genes that share ontologies with FOXRED2: view

No data available for Pathways by source and SIGNOR curated interactions for FOXRED2 Gene

Drugs & Compounds for FOXRED2 Gene

(1) Drugs for FOXRED2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
genes like me logo Genes that share compounds with FOXRED2: view

Transcripts for FOXRED2 Gene

Unigene Clusters for FOXRED2 Gene

FAD-dependent oxidoreductase domain containing 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOXRED2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXRED2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d ^ 12
SP1: -
SP2: - - -
SP3: -
SP4: - -
SP5:
SP6: - -
SP7:
SP8: -
SP9:
SP10: - - - -

Relevant External Links for FOXRED2 Gene

GeneLoc Exon Structure for
FOXRED2
ECgene alternative splicing isoforms for
FOXRED2

Expression for FOXRED2 Gene

mRNA expression in normal human tissues for FOXRED2 Gene

Protein differential expression in normal tissues from HIPED for FOXRED2 Gene

This gene is overexpressed in Liver, secretome (61.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FOXRED2 Gene



SOURCE GeneReport for Unigene cluster for FOXRED2 Gene Hs.387601

genes like me logo Genes that share expression patterns with FOXRED2: view

Protein tissue co-expression partners for FOXRED2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FOXRED2 Gene

Orthologs for FOXRED2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FOXRED2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOXRED2 35
  • 84.29 (n)
  • 83.46 (a)
FOXRED2 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXRED2 35
  • 87.35 (n)
  • 87.44 (a)
FOXRED2 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxred2 35
  • 84.59 (n)
  • 84.94 (a)
Foxred2 16
Foxred2 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FOXRED2 35
  • 99.22 (n)
  • 98.98 (a)
FOXRED2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxred2 35
  • 84.04 (n)
  • 84.79 (a)
oppossum
(Monodelphis domestica)
Mammalia FOXRED2 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOXRED2 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOXRED2 35
  • 71.99 (n)
  • 73.89 (a)
FOXRED2 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXRED2 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia foxred2 35
  • 63.3 (n)
  • 65.14 (a)
Str.14404 35
zebrafish
(Danio rerio)
Actinopterygii foxred2 35
  • 59.77 (n)
  • 59.11 (a)
foxred2 36
  • 52 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10616 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToMany
-- 36
  • 32 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
CSA.6197 36
  • 51 (a)
OneToMany
Species with no ortholog for FOXRED2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXRED2 Gene

ENSEMBL:
Gene Tree for FOXRED2 (if available)
TreeFam:
Gene Tree for FOXRED2 (if available)

Paralogs for FOXRED2 Gene

No data available for Paralogs for FOXRED2 Gene

Variants for FOXRED2 Gene

Sequence variations from dbSNP and Humsavar for FOXRED2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs2564 -- 36,489,112(+) GTGCC(A/C)GCCCG utr-variant-3-prime
rs760718 - 36,504,759(+) TACAA(A/G)GAGGA missense, reference
rs1000427 -- 36,494,058(+) ACAAC(A/G)TGAGG intron-variant
rs1076641 -- 36,499,469(-) ttgtt(A/G)ttttt intron-variant
rs1076642 -- 36,499,574(-) ATCTC(A/G)GCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOXRED2 Gene

Variant ID Type Subtype PubMed ID
nsv520497 CNV Gain 19592680
nsv834186 CNV Loss 17160897

Variation tolerance for FOXRED2 Gene

Residual Variation Intolerance Score: 73.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.80; 73.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXRED2 Gene

HapMap Linkage Disequilibrium report
FOXRED2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXRED2 Gene

Disorders for FOXRED2 Gene

Relevant External Links for FOXRED2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXRED2
genes like me logo Genes that share disorders with FOXRED2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXRED2 Gene

Publications for FOXRED2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. The flavoprotein FOXRED2 reductively activates nitro-chloromethylbenzindolines and other hypoxia-targeting prodrugs. (PMID: 24632291) Hunter F.W. … Pruijn F.B. (Biochem. Pharmacol. 2014) 67
  3. Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate. (PMID: 23097496) Tyler R.E. … Kopito R.R. (Mol. Biol. Cell 2012) 67
  4. Defining human ERAD networks through an integrative mapping strategy. (PMID: 22119785) Christianson J.C. … Kopito R.R. (Nat. Cell Biol. 2012) 67
  5. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B. … Wang L.S. (J. Proteome Res. 2012) 67

Products for FOXRED2 Gene

Sources for FOXRED2 Gene

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