FOXRED2 Gene
protein-coding GIFtS: 44
GCID: GC22M036883
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|
FAD-dependent oxidoreductase domain containing 2
| |
Aliases
for FOXRED2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| FAD-Dependent Oxidoreductase Domain Containing 21 2 | | Endoplasmic Reticulum Flavoprotein Associated With Degradation2 3 | | ERFAD2 3 | | FLJ233221 | | FAD-Dependent Oxidoreductase Domain-Containing Protein 22 |
Export aliases for FOXRED2 gene to outside databasesPrevious GC identifers: GC22M035214 GC22M019851 |
Summaries
for FOXRED2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FXRD2_HUMAN, Q8IWF2Function: Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bindnon-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequentdegradation
|
Genomic Views
for FOXRED2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FOXRED2 gene promoter:
MZF-1 USF-1 Pax-2 STAT3 Pax-2a
Other transcription factors
Search SABiosciences Chromatin IP Primers for FOXRED2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXRED2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q12.3 Ensembl cytogenetic band: 22q12.3 HGNC cytogenetic band: 22q12.3FOXRED2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M036883: view genomic region
(about GC identifiers)
Start:
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36,883,233 bp from pter |
End:
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36,903,148 bp from pter |
Size:
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19,916 bases |
Orientation:
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minus strand |
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Proteins
for FOXRED2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FXRD2_HUMAN, Q8IWF2 (See
protein sequence)Recommended Name: FAD-dependent oxidoreductase domain-containing protein 2 precursor Size: 684 amino acids; 77791 Da
Cofactor: FAD
Subunit: Interacts with SEL1L. May interact with OS9 and DNAJC10
Subcellular location: Endoplasmic reticulum lumen
Secondary accessions: B2RDI4 Q8N378 Q96BD1 Q9H5L5 Q9H6M8Alternative splicing: 2 isoforms: Q8IWF2-1 Q8IWF2-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FOXRED2: NX_Q8IWF2
Post-translational modifications:
N-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IWF2
FOXRED2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001095841.1 NP_079231.4
ENSEMBL proteins: ENSP00000380401 ENSP00000216187 ENSP00000382543 ENSP00000380400 ENSP00000409692
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
FOXRED2 for ontologies About GeneDecksing
FOXRED2 Antibody Products:
Assay Products for FOXRED2: |
Protein
Domains /
Families
for FOXRED2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8IWF2 UniProtKB/Swiss-Prot: FXRD2_HUMAN, Q8IWF2Similarity: Belongs to the FOXRED2 family |
Function
for FOXRED2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FXRD2_HUMAN, Q8IWF2Function: Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bindnon-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequentdegradation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXRED2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXRED2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): FOXRED2 (NM_024955) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOXRED2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXRED2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXRED2 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
FOXRED2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for FOXRED2:
|
Pathways & Interactions
for FOXRED2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOXRED2
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/7 Interacting proteins for FOXRED2 (Q8IWF23 ENSP000002161874) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030433 | ER-associated protein catabolic process |
IMP | 19706418 |
FOXRED2 for ontologies About GeneDecksing
|
Drugs & Compounds
for FOXRED2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FOXRED2
1 HMDB Compound for FOXRED2 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| FAD | 1H-Purin-6-amine flavin dinucleotide (see all 21) | 146-14-5 | -- |
Search CenterWatch for drugs/clinical trials and news about FOXRED2 / FXRD2
|
Transcripts
for FOXRED2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FOXRED2 gene (2 alternative transcripts): NM_001102371.1 NM_024955.5 Unigene Cluster for FOXRED2: FAD-dependent oxidoreductase domain containing 2 Hs.387601 [show with all ESTs]Unigene Representative Sequence: NM_0249555 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000397224(uc003apm.4 uc003apn.4 uc003apo.4 uc003app.4)
ENST00000216187 ENST00000366463 ENST00000397223 ENST00000423980
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXRED2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXRED2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FOXRED2 (NM_024955) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOXRED2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXRED2 |
Additional cDNA sequence: AK025714.1 AK091053.1 AK225347.1 AK315555.1 BC015726.1 BC027716.2 BC040351.1 CR456444.1 17 DOTS entries: DT.100752508 DT.100808989 DT.97821073 DT.100038404 DT.100808991 DT.97843145 DT.100649803 DT.100802337 DT.100754773 DT.100754777 DT.430890 DT.100808981 DT.408568 DT.95212278 DT.99983135 DT.91860126 DT.92435426 24/536 AceView cDNA sequences (see all 536): CN484300 BX341512 AA363694 BQ691701 BQ892409 BM835596 T55617 F10516 BU615316 AI346017 BM457059 BX401367 BQ271599 AI129013 BQ880310 BQ685876 BQ436458 BU166545 AJ573072 CR456444 BU197096 BQ690115 AL118925 N41898
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for FOXRED2 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12 |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FOXRED2
|
Expression
for FOXRED2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FOXRED2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGACGCACTC
About this image
See FOXRED2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FOXRED2
SOURCE GeneReport for Unigene cluster: Hs.387601
SABiosciences Custom PCR Arrays for FOXRED2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOXRED2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FOXRED2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXRED2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXRED2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXRED2 |
Orthologs
for FOXRED2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FOXRED2 gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for FOXRED2 (if available)
TreeFam Gene Tree for FOXRED2 (if available) |
Paralogs
for FOXRED2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FOXRED2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FOXRED2 (36883233 - 36903148 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FOXRED2
1 CNV: 5183 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOXRED2 |
|
Disorders
/ Diseases
for FOXRED2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 FOXRED2 for disorders About MalaCards
FOXRED2 for disorders About GeneDecksing
OMIM gene information: 613777
OMIM disorders: --
Export disorders for FOXRED2 gene to outside databases
|
Publications
for FOXRED2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FOXRED2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with FOXRED2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A luminal flavoprotein in endoplasmic reticulum-associated degradation. (PubMed id 19706418)1, 2 Riemer J.... Ellgaard L. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Proteomic identification of common SCF ubiquitin ligas e FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for FOXRED2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FOXRED2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FOXRED2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FOXRED2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FOXRED2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FOXRED2 gene:
Search GeneIP for patents involving FOXRED2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FOXRED2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for FOXRED2 | | OriGene Custom Protein Services for FOXRED2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FOXRED2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOXRED2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXRED2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXRED2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXRED2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXRED2 |
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 | | | FOXRED2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXRED2 |
|  |  |  | | | | Search ThermoFisher Antibodies for FOXRED2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXRED2 |
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