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Aliases for FOXRED2 Gene

Aliases for FOXRED2 Gene

  • FAD Dependent Oxidoreductase Domain Containing 2 2 3 5
  • Endoplasmic Reticulum Flavoprotein Associated With Degradation 3 4
  • ER Flavoprotein Associated With Degradation 2 3
  • ERFAD 3 4
  • FAD-Dependent Oxidoreductase Domain-Containing Protein 2 3
  • FAD-Dependent Oxidoreductase Domain Containing 2 2

External Ids for FOXRED2 Gene

Previous GeneCards Identifiers for FOXRED2 Gene

  • GC22M035214
  • GC22M036883
  • GC22M019851

Summaries for FOXRED2 Gene

GeneCards Summary for FOXRED2 Gene

FOXRED2 (FAD Dependent Oxidoreductase Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and glycoprotein binding.

UniProtKB/Swiss-Prot for FOXRED2 Gene

  • Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXRED2 Gene

Genomics for FOXRED2 Gene

Regulatory Elements for FOXRED2 Gene

Enhancers for FOXRED2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F036457 1.7 FANTOM5 Ensembl ENCODE 13.4 +41.8 41813 15.8 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 ZNF548 FOS FOXRED2 ENSG00000252225 RPS15AP38 TXN2 ENSG00000228719 EIF3D MYH9 LOC105373018
GH22F036348 1.8 FANTOM5 Ensembl ENCODE 12 +138.3 138281 40.9 MLX CREB3L1 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TXN2 ENSG00000252225 FOXRED2 CSF2RB MYH9 LOC105377199 APOL3 EIF3D ENSG00000228719 APOL2
GH22F036418 1.7 FANTOM5 Ensembl ENCODE 12.6 +87.2 87190 3.0 MLX ARID4B FEZF1 DMAP1 YY1 SLC30A9 ZNF263 SP5 NFYC MXD4 FOXRED2 RPS15AP38 GC22M036384
GH22F036394 1.7 FANTOM5 Ensembl ENCODE 11.4 +104.0 103952 18.3 PKNOX1 ARID4B FEZF1 DMAP1 YY1 SLC30A9 FOS SP3 SP5 NFYC ENSG00000252225 FOXRED2 CSF2RB TXN2 ENSG00000228719 EIF3D MYH9 GC22M036384 RPS15AP38
GH22F036431 1.6 FANTOM5 Ensembl ENCODE 11.7 +72.1 72104 6.0 PKNOX1 MLX ARID4B FEZF1 DMAP1 ZNF48 SLC30A9 ZNF766 GLIS2 CBX5 FOXRED2 TXN2 ENSG00000252225 RPS15AP38
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FOXRED2 on UCSC Golden Path with GeneCards custom track

Promoters for FOXRED2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000617794 201 1001 ARNT MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF207 ZNF143 FOS

Genomic Location for FOXRED2 Gene

Chromosome:
22
Start:
36,487,186 bp from pter
End:
36,507,101 bp from pter
Size:
19,916 bases
Orientation:
Minus strand

Genomic View for FOXRED2 Gene

Genes around FOXRED2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXRED2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXRED2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXRED2 Gene

Proteins for FOXRED2 Gene

  • Protein details for FOXRED2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWF2-FXRD2_HUMAN
    Recommended name:
    FAD-dependent oxidoreductase domain-containing protein 2
    Protein Accession:
    Q8IWF2
    Secondary Accessions:
    • B2RDI4
    • Q8N378
    • Q96BD1
    • Q9H5L5
    • Q9H6M8

    Protein attributes for FOXRED2 Gene

    Size:
    684 amino acids
    Molecular mass:
    77791 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Interacts with SEL1L. May interact with OS9 and DNAJC10. Interacts with TXNDC16 (PubMed:21359175).

    Alternative splice isoforms for FOXRED2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXRED2 Gene

Post-translational modifications for FOXRED2 Gene

Other Protein References for FOXRED2 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for FOXRED2

No data available for DME Specific Peptides for FOXRED2 Gene

Domains & Families for FOXRED2 Gene

Protein Domains for FOXRED2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FOXRED2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IWF2

UniProtKB/Swiss-Prot:

FXRD2_HUMAN :
  • Belongs to the FOXRED2 family.
Family:
  • Belongs to the FOXRED2 family.
genes like me logo Genes that share domains with FOXRED2: view

No data available for Gene Families for FOXRED2 Gene

Function for FOXRED2 Gene

Molecular function for FOXRED2 Gene

UniProtKB/Swiss-Prot Function:
Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation.

Gene Ontology (GO) - Molecular Function for FOXRED2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IPI 21359175
GO:0004497 monooxygenase activity IBA --
GO:0005515 protein binding IPI 19706418
GO:0016491 oxidoreductase activity IEA --
GO:0050660 flavin adenine dinucleotide binding IDA 19706418
genes like me logo Genes that share ontologies with FOXRED2: view
genes like me logo Genes that share phenotypes with FOXRED2: view

Animal Model Products

miRNA for FOXRED2 Gene

miRTarBase miRNAs that target FOXRED2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FOXRED2 Gene

Localization for FOXRED2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXRED2 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXRED2 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
golgi apparatus 2
mitochondrion 1
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FOXRED2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005788 endoplasmic reticulum lumen IEA,IDA 19706418
genes like me logo Genes that share ontologies with FOXRED2: view

Pathways & Interactions for FOXRED2 Gene

SuperPathways for FOXRED2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXRED2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IMP 19706418
GO:0055114 oxidation-reduction process IEA,IBA --
genes like me logo Genes that share ontologies with FOXRED2: view

No data available for Pathways by source and SIGNOR curated interactions for FOXRED2 Gene

Drugs & Compounds for FOXRED2 Gene

(1) Drugs for FOXRED2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
genes like me logo Genes that share compounds with FOXRED2: view

Transcripts for FOXRED2 Gene

Unigene Clusters for FOXRED2 Gene

FAD-dependent oxidoreductase domain containing 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXRED2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d ^ 12
SP1: -
SP2: - - -
SP3: -
SP4: - -
SP5:
SP6: - -
SP7:
SP8: -
SP9:
SP10: - - - -

Relevant External Links for FOXRED2 Gene

GeneLoc Exon Structure for
FOXRED2
ECgene alternative splicing isoforms for
FOXRED2

Expression for FOXRED2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FOXRED2 Gene

Protein differential expression in normal tissues from HIPED for FOXRED2 Gene

This gene is overexpressed in Liver, secretome (61.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FOXRED2 Gene



Protein tissue co-expression partners for FOXRED2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FOXRED2 Gene:

FOXRED2

SOURCE GeneReport for Unigene cluster for FOXRED2 Gene:

Hs.387601
genes like me logo Genes that share expression patterns with FOXRED2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FOXRED2 Gene

Orthologs for FOXRED2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FOXRED2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXRED2 34 35
  • 99.22 (n)
dog
(Canis familiaris)
Mammalia FOXRED2 34 35
  • 87.35 (n)
mouse
(Mus musculus)
Mammalia Foxred2 34 16 35
  • 84.59 (n)
cow
(Bos Taurus)
Mammalia FOXRED2 34 35
  • 84.29 (n)
rat
(Rattus norvegicus)
Mammalia Foxred2 34
  • 84.04 (n)
oppossum
(Monodelphis domestica)
Mammalia FOXRED2 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOXRED2 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOXRED2 34 35
  • 71.99 (n)
lizard
(Anolis carolinensis)
Reptilia FOXRED2 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia foxred2 34
  • 63.3 (n)
Str.14404 34
zebrafish
(Danio rerio)
Actinopterygii foxred2 34 35
  • 59.77 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 51 (a)
OneToMany
CSA.6197 35
  • 51 (a)
OneToMany
-- 35
  • 46 (a)
OneToMany
-- 35
  • 32 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10616 34
Species where no ortholog for FOXRED2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXRED2 Gene

ENSEMBL:
Gene Tree for FOXRED2 (if available)
TreeFam:
Gene Tree for FOXRED2 (if available)

Paralogs for FOXRED2 Gene

No data available for Paralogs for FOXRED2 Gene

Variants for FOXRED2 Gene

Sequence variations from dbSNP and Humsavar for FOXRED2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000427 -- 36,494,058(+) ACAAC(A/G)TGAGG intron-variant
rs1076641 -- 36,499,469(-) ttgtt(A/G)ttttt intron-variant
rs1076642 -- 36,499,574(-) ATCTC(A/G)GCTCA intron-variant
rs11089794 -- 36,498,236(+) CCTCA(C/T)TGACC intron-variant, nc-transcript-variant, downstream-variant-500B
rs111233587 -- 36,489,245(+) GAGTC(-/A)GGGGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FOXRED2 Gene

Variant ID Type Subtype PubMed ID
nsv834186 CNV loss 17160897
nsv520497 CNV gain 19592680
nsv1060004 CNV gain 25217958
esv2760722 CNV gain 21179565

Variation tolerance for FOXRED2 Gene

Residual Variation Intolerance Score: 73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.80; 73.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXRED2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXRED2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXRED2 Gene

Disorders for FOXRED2 Gene

Relevant External Links for FOXRED2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXRED2

No disorders were found for FOXRED2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXRED2 Gene

Publications for FOXRED2 Gene

  1. Identification of the PDI-family member ERp90 as an interaction partner of ERFAD. (PMID: 21359175) Riemer J. … Ellgaard L. (PLoS ONE 2011) 3 4 64
  2. A luminal flavoprotein in endoplasmic reticulum-associated degradation. (PMID: 19706418) Riemer J. … Ellgaard L. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64

Products for FOXRED2 Gene

Sources for FOXRED2 Gene

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