Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FOXRED1 Gene

Aliases for FOXRED1 Gene

  • FAD-Dependent Oxidoreductase Domain Containing 1 2 3
  • FAD-Dependent Oxidoreductase Domain-Containing Protein 1 3
  • EC 1.-.-.- 4
  • FP634 3
  • H17 3

External Ids for FOXRED1 Gene

Previous GeneCards Identifiers for FOXRED1 Gene

  • GC11P125645
  • GC11P126139
  • GC11P122081

Summaries for FOXRED1 Gene

Entrez Gene Summary for FOXRED1 Gene

  • This gene encodes a protein that contains a FAD-dependent oxidoreductase domain. The encoded protein is localized to the mitochondria and may function as a chaperone protein required for the function of mitochondrial complex I. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for FOXRED1 Gene

FOXRED1 (FAD-Dependent Oxidoreductase Domain Containing 1) is a Protein Coding gene. Diseases associated with FOXRED1 include mitochondrial complex i deficiency and peanut allergic reaction. GO annotations related to this gene include oxidoreductase activity.

UniProtKB/Swiss-Prot for FOXRED1 Gene

  • Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed:20858599, PubMed:25678554). Involved in mid-late stages of complex I assembly (PubMed:25678554).

Gene Wiki entry for FOXRED1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXRED1 Gene

Genomics for FOXRED1 Gene

Regulatory Elements for FOXRED1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FOXRED1 Gene

Start:
126,269,040 bp from pter
End:
126,278,132 bp from pter
Size:
9,093 bases
Orientation:
Plus strand

Genomic View for FOXRED1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXRED1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXRED1 Gene

Proteins for FOXRED1 Gene

  • Protein details for FOXRED1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CU9-FXRD1_HUMAN
    Recommended name:
    FAD-dependent oxidoreductase domain-containing protein 1
    Protein Accession:
    Q96CU9
    Secondary Accessions:
    • B3KN84
    • B4DHU2
    • Q71MG0
    • Q9BU39
    • Q9UKY9

    Protein attributes for FOXRED1 Gene

    Size:
    486 amino acids
    Molecular mass:
    53812 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Associates with components of the mitochondrial respiratory chain complex I.

    Alternative splice isoforms for FOXRED1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXRED1 Gene

Proteomics data for FOXRED1 Gene at MOPED

Post-translational modifications for FOXRED1 Gene

  • Ubiquitination at Lys33, Lys42, and Lys259
  • Modification sites at PhosphoSitePlus

Other Protein References for FOXRED1 Gene

No data available for DME Specific Peptides for FOXRED1 Gene

Domains for FOXRED1 Gene

Protein Domains for FOXRED1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FOXRED1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FOXRED1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FOXRED1 Gene

Function for FOXRED1 Gene

Molecular function for FOXRED1 Gene

UniProtKB/Swiss-Prot Function: Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed:20858599, PubMed:25678554). Involved in mid-late stages of complex I assembly (PubMed:25678554).

Enzyme Numbers (IUBMB) for FOXRED1 Gene

Gene Ontology (GO) - Molecular Function for FOXRED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with FOXRED1: view

Animal Model Products

CRISPR Products

miRNA for FOXRED1 Gene

miRTarBase miRNAs that target FOXRED1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOXRED1

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FOXRED1 Gene

Localization for FOXRED1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXRED1 Gene

Mitochondrion inner membrane; Single-pass membrane protein. Note=According to a report, it is associated with the matrix face of the mitochondrial inner membrane and does not contain any transmembrane region. However, one transmembrane domain is clearly predicted by different methods (Probable). {ECO:0000305 PubMed:25678554}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXRED1 Gene COMPARTMENTS Subcellular localization image for FOXRED1 gene
Compartment Confidence
mitochondrion 4
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for FOXRED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane IDA 25678554
GO:0005747 mitochondrial respiratory chain complex I IMP 20858599
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FOXRED1: view

Pathways for FOXRED1 Gene

SuperPathways for FOXRED1 Gene

No Data Available

Interacting Proteins for FOXRED1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000263578%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000312618%0d%0a9606.ENSP00000366135%0d%0a
Selected Interacting proteins: ENSP00000263578 Q96CU9-FXRD1_HUMAN for FOXRED1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for FOXRED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0032981 mitochondrial respiratory chain complex I assembly IMP 25678554
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with FOXRED1: view

No data available for Pathways by source for FOXRED1 Gene

Compounds for FOXRED1 Gene

(1) HMDB Compounds for FOXRED1 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
genes like me logo Genes that share compounds with FOXRED1: view

Transcripts for FOXRED1 Gene

Unigene Clusters for FOXRED1 Gene

FAD-dependent oxidoreductase domain containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOXRED1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXRED1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - -
SP12: - - - - -
SP13: - - -
SP14:
SP15: - - - - -
SP16: - - - - - -
SP17: -
SP18: - - -
SP19:
SP20: - - -

ExUns: 11b · 11c ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14a · 14b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for FOXRED1 Gene

GeneLoc Exon Structure for
FOXRED1
ECgene alternative splicing isoforms for
FOXRED1

Expression for FOXRED1 Gene

mRNA expression in normal human tissues for FOXRED1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FOXRED1 Gene

SOURCE GeneReport for Unigene cluster for FOXRED1 Gene Hs.317190

genes like me logo Genes that share expressions with FOXRED1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FOXRED1 Gene

Orthologs for FOXRED1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXRED1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXRED1 35
  • 97.81 (n)
  • 97.18 (a)
FOXRED1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FOXRED1 35
  • 84.36 (n)
  • 82.38 (a)
FOXRED1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXRED1 35
  • 85.22 (n)
  • 83.82 (a)
FOXRED1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxred1 35
  • 82.65 (n)
  • 79.42 (a)
Foxred1 16
Foxred1 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FOXRED1 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
chicken
(Gallus gallus)
Aves FOXRED1 35
  • 65.5 (n)
  • 62 (a)
FOXRED1 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXRED1 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia foxred1 35
  • 62.04 (n)
  • 61.47 (a)
Str.16899 35
zebrafish
(Danio rerio)
Actinopterygii Dr.11804 35
foxred1 35
  • 61.63 (n)
  • 61.33 (a)
foxred1 36
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009080 35
  • 56.87 (n)
  • 53.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3270 36
  • 47 (a)
OneToMany
l(2)37Bb 35
  • 52.21 (n)
  • 43.63 (a)
l(2)37Bb 36
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_M04B2.4 35
  • 46.68 (n)
  • 40.3 (a)
M04B2.4 36
  • 34 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for FOXRED1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FOXRED1 Gene

ENSEMBL:
Gene Tree for FOXRED1 (if available)
TreeFam:
Gene Tree for FOXRED1 (if available)

Paralogs for FOXRED1 Gene

No data available for Paralogs for FOXRED1 Gene

Variants for FOXRED1 Gene

Sequence variations from dbSNP and Humsavar for FOXRED1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs585209 -- 126,276,108(+) CATTG(G/T)GATCA missense, reference, nc-transcript-variant
rs591163 -- 126,278,537(-) TGTAC(A/G)TGGGG downstream-variant-500B
rs594318 -- 126,277,818(-) GGCCT(C/G)CCTGA utr-variant-3-prime, nc-transcript-variant
rs651864 -- 126,273,804(+) CAGAT(A/G)GTATA intron-variant
rs663312 -- 126,274,053(+) TCTCA(C/G)AGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOXRED1 Gene

Variant ID Type Subtype PubMed ID
nsv898440 CNV Loss 21882294
nsv513341 CNV Insertion 21212237

Relevant External Links for FOXRED1 Gene

HapMap Linkage Disequilibrium report
FOXRED1
Human Gene Mutation Database (HGMD)
FOXRED1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXRED1 Gene

Disorders for FOXRED1 Gene

(2) OMIM Diseases for FOXRED1 Gene (613622)

UniProtKB/Swiss-Prot

FXRD1_HUMAN
  • Mitochondrial complex I deficiency (MT-C1D) [MIM:252010]: A disorder of the mitochondrial respiratory chain that causes a wide range of clinical manifestations from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. {ECO:0000269 PubMed:20818383, ECO:0000269 PubMed:20858599}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for FOXRED1 Gene

Relevant External Links for FOXRED1

Genetic Association Database (GAD)
FOXRED1
Human Genome Epidemiology (HuGE) Navigator
FOXRED1
genes like me logo Genes that share disorders with FOXRED1: view

Publications for FOXRED1 Gene

  1. Identification of differentially expressed genes associated with HER- 2/neu overexpression in human breast cancer cells. (PMID: 10497265) Oh J.J. … Slamon D.J. (Nucleic Acids Res. 1999) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Characterization of mitochondrial FOXRED1 in the assembly of respiratory chain complex I. (PMID: 25678554) Formosa L.E. … Ryan M.T. (Hum. Mol. Genet. 2015) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for FOXRED1 Gene

Sources for FOXRED1 Gene

Back to Top

Content