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Aliases for FOXR2 Gene

Aliases for FOXR2 Gene

  • Forkhead Box R2 2 3
  • Forkhead Box Protein N6 3 4
  • FOXN6 3 4
  • Forkhead Box Protein R2 3

External Ids for FOXR2 Gene

Previous GeneCards Identifiers for FOXR2 Gene

  • GC0XP054590
  • GC0XP055532
  • GC0XP052703

Summaries for FOXR2 Gene

GeneCards Summary for FOXR2 Gene

FOXR2 (Forkhead Box R2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding and double-stranded DNA binding. An important paralog of this gene is FOXK2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXR2 Gene

Genomics for FOXR2 Gene

Regulatory Elements for FOXR2 Gene

Genomic Location for FOXR2 Gene

Start:
55,623,400 bp from pter
End:
55,626,188 bp from pter
Size:
2,789 bases
Orientation:
Plus strand

Genomic View for FOXR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXR2 Gene

Proteins for FOXR2 Gene

  • Protein details for FOXR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PJQ5-FOXR2_HUMAN
    Recommended name:
    Forkhead box protein R2
    Protein Accession:
    Q6PJQ5
    Secondary Accessions:

    Protein attributes for FOXR2 Gene

    Size:
    311 amino acids
    Molecular mass:
    35924 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXR2 Gene

Proteomics data for FOXR2 Gene at MOPED

Post-translational modifications for FOXR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXR2 Gene

Domains for FOXR2 Gene

Gene Families for FOXR2 Gene

HGNC:
  • FOX :Forkhead boxes

Protein Domains for FOXR2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FOXR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PJQ5

UniProtKB/Swiss-Prot:

FOXR2_HUMAN :
  • Q6PJQ5
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXR2: view

Function for FOXR2 Gene

Gene Ontology (GO) - Molecular Function for FOXR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXR2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FOXR2 Gene

Localization for FOXR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXR2 Gene

Gene Ontology (GO) - Cellular Components for FOXR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with FOXR2: view

No data available for Subcellular locations from COMPARTMENTS for FOXR2 Gene

Pathways for FOXR2 Gene

SuperPathways for FOXR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0009653 anatomical structure morphogenesis IBA --
genes like me logo Genes that share ontologies with FOXR2: view

No data available for Pathways by source for FOXR2 Gene

Transcripts for FOXR2 Gene

mRNA/cDNA for FOXR2 Gene

(6) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXR2 Gene

Forkhead box R2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOXR2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXR2 Gene

No ASD Table

Relevant External Links for FOXR2 Gene

GeneLoc Exon Structure for
FOXR2
ECgene alternative splicing isoforms for
FOXR2

Expression for FOXR2 Gene

mRNA expression in normal human tissues for FOXR2 Gene

mRNA differential expression in normal tissues according to GTEx for FOXR2 Gene

This gene is overexpressed in Testis (51.3).

SOURCE GeneReport for Unigene cluster for FOXR2 Gene Hs.364260

mRNA Expression by UniProt/SwissProt for FOXR2 Gene

Q6PJQ5-FOXR2_HUMAN
Tissue specificity: Expressed in breast cancer cell lines and primary cancer.
genes like me logo Genes that share expressions with FOXR2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for FOXR2 Gene

Orthologs for FOXR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXR2 35
  • 98.5 (n)
  • 96.14 (a)
FOXR2 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FOXR2 35
  • 80.06 (n)
  • 70.1 (a)
FOXR2 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXR2 35
  • 79.57 (n)
  • 69.03 (a)
FOXR2 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxr2 35
  • 69.6 (n)
  • 56.27 (a)
Foxr2 16
Foxr2 36
  • 54 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 43 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Foxr2 35
  • 67.8 (n)
  • 54.92 (a)
zebrafish
(Danio rerio)
Actinopterygii FOXR1 36
  • 30 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CHES-1-like 36
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5413 36
  • 6 (a)
OneToMany
Species with no ortholog for FOXR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXR2 Gene

ENSEMBL:
Gene Tree for FOXR2 (if available)
TreeFam:
Gene Tree for FOXR2 (if available)

Paralogs for FOXR2 Gene

Selected SIMAP similar genes for FOXR2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXR2: view

Variants for FOXR2 Gene

Sequence variations from dbSNP and Humsavar for FOXR2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2375465 - 55,624,568(+) TCGTG(C/T)CTTAG missense, reference
rs6611417 -- 55,622,397(+) AAAGG(A/T)AGAAT upstream-variant-2KB
rs6612346 -- 55,623,168(+) ttgca(A/G)ggctg upstream-variant-2KB
rs7884414 -- 55,624,734(+) CCAGC(A/C)TGGTT utr-variant-3-prime
rs12835097 -- 55,626,634(+) GAAAA(C/T)AAGAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FOXR2 Gene

Variant ID Type Subtype PubMed ID
nsv435891 CNV Deletion 17901297
esv2740175 CNV Deletion 23290073
nsv524155 CNV Gain 19592680
nsv508776 CNV Insertion 20534489

Relevant External Links for FOXR2 Gene

HapMap Linkage Disequilibrium report
FOXR2
Locus Specific Mutation Databases (LSDB)
FOXR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXR2 Gene

Disorders for FOXR2 Gene

No disorders were found for FOXR2 Gene.

No data available for UniProtKB/Swiss-Prot for FOXR2 Gene

Publications for FOXR2 Gene

  1. Identification and characterization of human FOXN6, mouse Foxn6, and rat Foxn6 genes in silico. (PMID: 15202009) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 2 3 4 23
  2. Identification and characterization of human FOXK1 gene in silico. (PMID: 15202027) Katoh M. … Katoh M. (Int. J. Mol. Med. 2004) 2 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for FOXR2 Gene

Sources for FOXR2 Gene

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