Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FOXR2 Gene

Aliases for FOXR2 Gene

  • Forkhead Box R2 2 3 5
  • Forkhead Box Protein N6 3 4
  • FOXN6 3 4

External Ids for FOXR2 Gene

Previous GeneCards Identifiers for FOXR2 Gene

  • GC0XP054590
  • GC0XP055532
  • GC0XP052703

Summaries for FOXR2 Gene

GeneCards Summary for FOXR2 Gene

FOXR2 (Forkhead Box R2) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXN2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXR2 Gene

Genomics for FOXR2 Gene

Regulatory Elements for FOXR2 Gene

Genomic Location for FOXR2 Gene

Chromosome:
X
Start:
55,623,400 bp from pter
End:
55,626,188 bp from pter
Size:
2,789 bases
Orientation:
Plus strand

Genomic View for FOXR2 Gene

Genes around FOXR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXR2 Gene

Proteins for FOXR2 Gene

  • Protein details for FOXR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PJQ5-FOXR2_HUMAN
    Recommended name:
    Forkhead box protein R2
    Protein Accession:
    Q6PJQ5

    Protein attributes for FOXR2 Gene

    Size:
    311 amino acids
    Molecular mass:
    35924 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXR2 Gene

Proteomics data for FOXR2 Gene at MOPED

Post-translational modifications for FOXR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FOXR2 Gene

Domains & Families for FOXR2 Gene

Gene Families for FOXR2 Gene

Protein Domains for FOXR2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FOXR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PJQ5

UniProtKB/Swiss-Prot:

FOXR2_HUMAN :
  • Contains 1 fork-head DNA-binding domain.
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXR2: view

Function for FOXR2 Gene

Gene Ontology (GO) - Molecular Function for FOXR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FOXR2: view

Phenotypes for FOXR2 Gene

genes like me logo Genes that share phenotypes with FOXR2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FOXR2 Gene

Localization for FOXR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXR2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXR2 Gene COMPARTMENTS Subcellular localization image for FOXR2 gene
Compartment Confidence
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for FOXR2 Gene

Pathways & Interactions for FOXR2 Gene

SuperPathways for FOXR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with FOXR2: view

No data available for Pathways by source and SIGNOR curated interactions for FOXR2 Gene

Drugs & Compounds for FOXR2 Gene

No Compound Related Data Available

Transcripts for FOXR2 Gene

mRNA/cDNA for FOXR2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXR2 Gene

Forkhead box R2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXR2 Gene

No ASD Table

Relevant External Links for FOXR2 Gene

GeneLoc Exon Structure for
FOXR2
ECgene alternative splicing isoforms for
FOXR2

Expression for FOXR2 Gene

mRNA expression in normal human tissues for FOXR2 Gene

mRNA differential expression in normal tissues according to GTEx for FOXR2 Gene

This gene is overexpressed in Testis (x51.3).

SOURCE GeneReport for Unigene cluster for FOXR2 Gene Hs.364260

mRNA Expression by UniProt/SwissProt for FOXR2 Gene

Q6PJQ5-FOXR2_HUMAN
Tissue specificity: Expressed in breast cancer cell lines and primary cancer.
genes like me logo Genes that share expression patterns with FOXR2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for FOXR2 Gene

Orthologs for FOXR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOXR2 35
  • 80.06 (n)
  • 70.1 (a)
FOXR2 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXR2 35
  • 79.57 (n)
  • 69.03 (a)
FOXR2 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxr2 35
  • 69.6 (n)
  • 56.27 (a)
Foxr2 16
Foxr2 36
  • 54 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FOXR2 35
  • 98.5 (n)
  • 96.14 (a)
FOXR2 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxr2 35
  • 67.8 (n)
  • 54.92 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 43 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii FOXR1 36
  • 30 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CHES-1-like 36
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5413 36
  • 6 (a)
OneToMany
Species with no ortholog for FOXR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXR2 Gene

ENSEMBL:
Gene Tree for FOXR2 (if available)
TreeFam:
Gene Tree for FOXR2 (if available)

Paralogs for FOXR2 Gene

Paralogs for FOXR2 Gene

(1) SIMAP similar genes for FOXR2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXR2: view

Variants for FOXR2 Gene

Sequence variations from dbSNP and Humsavar for FOXR2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs2375465 - 55,624,568(+) TCGTG(C/T)CTTAG reference, missense
rs6611417 -- 55,622,397(+) AAAGG(A/T)AGAAT upstream-variant-2KB
rs6612346 -- 55,623,168(+) ttgca(A/G)ggctg upstream-variant-2KB
rs7884414 -- 55,624,734(+) CCAGC(A/C)TGGTT utr-variant-3-prime
rs12835097 -- 55,626,634(+) GAAAA(C/T)AAGAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FOXR2 Gene

Variant ID Type Subtype PubMed ID
nsv435891 CNV Deletion 17901297
esv2740175 CNV Deletion 23290073
nsv524155 CNV Gain 19592680
nsv508776 CNV Insertion 20534489

Variation tolerance for FOXR2 Gene

Residual Variation Intolerance Score: 76.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXR2 Gene

HapMap Linkage Disequilibrium report
FOXR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXR2 Gene

Disorders for FOXR2 Gene

Relevant External Links for FOXR2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXR2

No disorders were found for FOXR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXR2 Gene

Publications for FOXR2 Gene

  1. Identification and characterization of human FOXN6, mouse Foxn6, and rat Foxn6 genes in silico. (PMID: 15202009) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 2 3 4 23 67
  2. Identification and characterization of human FOXK1 gene in silico. (PMID: 15202027) Katoh M. … Katoh M. (Int. J. Mol. Med. 2004) 2 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3

Products for FOXR2 Gene

Sources for FOXR2 Gene

Back to Top

Content