FOXR2 Gene
protein-coding GIFtS: 40
GCID: GC0XP055666
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|
forkhead box R2
| |
Aliases
for FOXR2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Forkhead Box R21 2 | | FOXN61 2 3 | | Forkhead Box Protein N62 3 | | MGC216581 | | Forkhead Box Protein R22 |
Export aliases for FOXR2 gene to outside databasesPrevious GC identifers: GC0XP054590 GC0XP055532 GC0XP052703 |
Summaries
for FOXR2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FOXR2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011630.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FOXR2 gene promoter:
GR AML1a GR-beta STAT1beta STAT1alpha STAT2 FOXO4 FOXO1a GR-alpha FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FOXR2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXR2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.21 Ensembl cytogenetic band: Xp11.21 HGNC cytogenetic band: Xp11FOXR2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP055666: view genomic region
(about GC identifiers)
Start:
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55,649,833 bp from pter |
End:
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55,652,621 bp from pter |
Size:
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2,789 bases |
Orientation:
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plus strand |
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Proteins
for FOXR2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FOXR2_HUMAN, Q6PJQ5 (See
protein sequence)Recommended Name: Forkhead box protein R2 Size: 311 amino acids; 35924 Da
Subcellular location: Nucleus (Potential)Explore the universe of human proteins at neXtProt for FOXR2: NX_Q6PJQ5
FOXR2 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_940853.1
ENSEMBL proteins: ENSP00000427329
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005667 | transcription factor complex |
IBA | -- |
FOXR2 for ontologies About GeneDecksing
FOXR2 Antibody Products:
Assay Products for FOXR2: |
Protein
Domains /
Families
for FOXR2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FOXR2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6PJQ5ProtoNet protein and cluster: Q6PJQ5 UniProtKB/Swiss-Prot: FOXR2_HUMAN, Q6PJQ5Similarity: Contains 1 fork-head DNA-binding domain |
Function
for FOXR2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXR2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXR2
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXR2 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003690 | double-stranded DNA binding |
IBA | -- | | GO:0003705 | RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity |
IBA | -- | | GO:0008134 | transcription factor binding |
IBA | -- | | GO:0008301 | DNA binding, bending |
IBA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
FOXR2 for ontologies About GeneDecksing
|
Pathways & Interactions
for FOXR2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOXR2
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007389 | pattern specification process |
IBA | -- | | GO:0009790 | embryo development |
IBA | -- | | GO:0009888 | tissue development |
IBA | -- | | GO:0048513 | organ development |
IBA | -- | | GO:0051090 | regulation of sequence-specific DNA binding transcription factor activity |
IBA | -- |
FOXR2 for ontologies About GeneDecksing
|
Drugs & Compounds
for FOXR2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FOXR2
Search CenterWatch for drugs/clinical trials and news about FOXR2
|
Transcripts
for FOXR2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FOXR2 gene: NM_198451.3 Unigene Cluster for FOXR2: Forkhead box R2 Hs.364260 [show with all ESTs]Unigene Representative Sequence: NM_1984511 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000339140(uc004duo.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXR2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXR2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FOXR2 (NM_198451) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOXR2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXR2 |
Additional cDNA sequence: BC012934.2 1 DOTS entry: DT.91650349 6 AceView cDNA sequences: BC012934 BM550294 BG575689 NM_198451 BQ000525 BE093825
GeneLoc Exon Structure
|
Expression
for FOXR2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FOXR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
Genevestigator expression for FOXR2
SOURCE GeneReport for Unigene cluster: Hs.364260
UniProtKB/Swiss-Prot: FOXR2_HUMAN, Q6PJQ5Tissue specificity: Expressed in breast cancer cell lines and primary cancer
SABiosciences Custom PCR Arrays for FOXR2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOXR2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FOXR2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXR2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXR2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXR2 |
Orthologs
for FOXR2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FOXR2 gene from 2/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:1717346 |
zgc:171734 |
26(a) |
1 → many |
5(60147744-60153128) |
fruit fly
(Drosophila melanogaster) |
Insecta |
fd3F6Crg-16 |
Circadianly Regulated Gene |
6(a)14(a) |
possible orthologpossible ortholog |
X(3698218-3704546) X(3688900-3691372) |
ENSEMBL Gene Tree for FOXR2 (if available)
TreeFam Gene Tree for FOXR2 (if available) |
Paralogs
for FOXR2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FOXR2 gene
- FOXR12
1 SIMAP similar gene for FOXR2 using alignment to 1 protein entry: FOXR2_HUMAN:FOXR1
FOXR2 for paralogs About GeneDecksing
|
Genomic Variants
for FOXR2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FOXR2 (55649833 - 55652621 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FOXR2
1 CNV: 23256
Locus Specific Mutation Databases (LSDB): FOXR2
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for FOXR2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FOXR2 for disorders About GeneDecksing
2  diseases for FOXR2: About MalaCardshermaphroditism breast cancer
Export disorders for FOXR2 gene to outside databases
|
Publications
for FOXR2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FOXR2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FOXR2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of human FOXN6, mouse Foxn6, and rat Foxn6 genes in silico. (PubMed id 15202009)1, 2, 3, 9 Katoh M. and Katoh M. (2004)
- Identification and characterization of human FOXK1 gene in silico. (PubMed id 15202027)1, 3, 9 Katoh M. and Katoh M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Germ-line mutation of Foxn5 gene in mouse lineage. (PubMed id 15289901)9 Katoh M. and Katoh M. (2004)
- Characterization of human FOXN4 gene in silico. (PubMed id 15492871)9 Katoh M. and Katoh M. (2004)
- Human FOX gene family (Review). (PubMed id 15492844)9 Katoh M. and Katoh M. (2004)
|
External Searches for FOXR2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FOXR2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FOXR2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FOXR2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FOXR2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FOXR2 gene:
Search GeneIP for patents involving FOXR2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FOXR2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FOXR2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOXR2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOXR2 | | | OriGene Protein Over-expression Lysate for FOXR2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FOXR2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXR2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXR2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | FOXR2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXR2 |
|  |  |  | | | | Search ThermoFisher Antibodies for FOXR2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXR2 |
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