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Aliases for FOXR1 Gene

Aliases for FOXR1 Gene

  • Forkhead Box R1 2 3
  • Forkhead Box Protein N5 3 4
  • FOXN5 3 4
  • Forkhead Box R1 Variant 1 3
  • Forkhead Box Protein R1 3
  • DLNB13 3

External Ids for FOXR1 Gene

Summaries for FOXR1 Gene

Entrez Gene Summary for FOXR1 Gene

  • This gene encodes a member of the forkhead box (FOX) family of transcription factors. FOX family members are monomeric, helix-turn-helix proteins with a core DNA-binding domain of approximately 110 aa. Many FOX transcription factors play roles in determining cell fates during early development. This forkhead box protein lacks the C-terminal basic region found in many other FOX family members. It is located within the 11q23.3 region which is commonly deleted in neuroblastomas. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXR1 Gene

FOXR1 (Forkhead Box R1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding and double-stranded DNA binding. An important paralog of this gene is FOXK2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXR1 Gene

Genomics for FOXR1 Gene

Genomic Location for FOXR1 Gene

Start:
118,971,707 bp from pter
End:
118,981,291 bp from pter
Size:
9,585 bases
Orientation:
Plus strand

Genomic View for FOXR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXR1 Gene

Regulatory Elements for FOXR1 Gene

Proteins for FOXR1 Gene

  • Protein details for FOXR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PIV2-FOXR1_HUMAN
    Recommended name:
    Forkhead box protein R1
    Protein Accession:
    Q6PIV2
    Secondary Accessions:
    • B0YJ15
    • Q08AS8
    • Q86UT9
    • Q8IXX2

    Protein attributes for FOXR1 Gene

    Size:
    292 amino acids
    Molecular mass:
    33310 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FOXR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXR1 Gene

Proteomics data for FOXR1 Gene at MOPED

Post-translational modifications for FOXR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXR1 Gene

Domains for FOXR1 Gene

Gene Families for FOXR1 Gene

HGNC:
  • FOX :Forkhead boxes

Protein Domains for FOXR1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FOXR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6PIV2

UniProtKB/Swiss-Prot:

FOXR1_HUMAN
Domain:
  • Contains 1 fork-head DNA-binding domain.:
    • Q6PIV2
genes like me logo Genes that share domains with FOXR1: view

Function for FOXR1 Gene

Gene Ontology (GO) - Molecular Function for FOXR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXR1: view

Phenotypes for FOXR1 Gene

GenomeRNAi human phenotypes for FOXR1:
genes like me logo Genes that share phenotypes with FOXR1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FOXR1 Gene

Localization for FOXR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXR1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXR1 Gene COMPARTMENTS Subcellular localization image for FOXR1 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FOXR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with FOXR1: view

Pathways for FOXR1 Gene

SuperPathways for FOXR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0009653 anatomical structure morphogenesis IBA --
genes like me logo Genes that share ontologies with FOXR1: view

No data available for Pathways by source for FOXR1 Gene

Transcripts for FOXR1 Gene

mRNA/cDNA for FOXR1 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXR1 Gene

Forkhead box R1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXR1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2: -

Relevant External Links for FOXR1 Gene

GeneLoc Exon Structure for
FOXR1
ECgene alternative splicing isoforms for
FOXR1

Expression for FOXR1 Gene

mRNA expression in normal human tissues for FOXR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXR1 Gene

This gene is overexpressed in Testis (42.2) and Ovary (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FOXR1 Gene

SOURCE GeneReport for Unigene cluster for FOXR1 Gene Hs.116679

genes like me logo Genes that share expressions with FOXR1: view

No data available for mRNA Expression by UniProt/SwissProt for FOXR1 Gene

Orthologs for FOXR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXR1 35
  • 99.43 (n)
  • 99.32 (a)
FOXR1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FOXR1 36
  • 75 (a)
OneToOne
LOC788135 35
  • 86.14 (n)
  • 81.44 (a)
dog
(Canis familiaris)
Mammalia FOXR1 35
  • 85.91 (n)
  • 83.85 (a)
FOXR1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxr1 35
  • 73.48 (n)
  • 65.75 (a)
Foxr1 16
Foxr1 36
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 42 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 52 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Foxr1 35
  • 80.05 (n)
  • 78.17 (a)
zebrafish
(Danio rerio)
Actinopterygii FOXR1 36
  • 30 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CHES-1-like 36
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5413 36
  • 7 (a)
OneToMany
Species with no ortholog for FOXR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXR1 Gene

ENSEMBL:
Gene Tree for FOXR1 (if available)
TreeFam:
Gene Tree for FOXR1 (if available)

Paralogs for FOXR1 Gene

Selected SIMAP similar genes for FOXR1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FOXR1: view

Variants for FOXR1 Gene

Sequence variations from dbSNP and Humsavar for FOXR1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs543583 -- 118,976,486(+) CATGA(A/G)CCGCT intron-variant
rs583886 -- 118,975,595(+) caagc(A/T)tgagc intron-variant
rs614245 -- 118,979,372(+) CCCCC(A/C/G/T)CTTCC intron-variant
rs626154 -- 118,978,124(+) gaggc(A/C)ggaga intron-variant
rs636958 -- 118,978,167(+) gagcc(A/C)agatc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOXR1 Gene

Variant ID Type Subtype PubMed ID
nsv819166 CNV Loss 19587683

Relevant External Links for FOXR1 Gene

HapMap Linkage Disequilibrium report
FOXR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXR1 Gene

Disorders for FOXR1 Gene

(2) Novoseek inferred disease relationships for FOXR1 Gene

Disease -log(P) Hits PubMed IDs
hematologic malignancies 49.9 1
tumors 0 1
genes like me logo Genes that share disorders with FOXR1: view

No data available for UniProtKB/Swiss-Prot for FOXR1 Gene

Publications for FOXR1 Gene

  1. Identification and characterization of human FOXN5 and rat Foxn5 genes in silico. (PMID: 15067358) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 2 3 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Human FOX gene family (Review). (PMID: 15492844) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 3 23
  4. Characterization of human FOXN4 gene in silico. (PMID: 15492871) Katoh M. … Katoh M. (Int. J. Mol. Med. 2004) 23
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FOXR1 Gene

Sources for FOXR1 Gene

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