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Aliases for FOXR1 Gene

Aliases for FOXR1 Gene

  • Forkhead Box R1 2 3 5
  • Forkhead Box Protein N5 3 4
  • FOXN5 3 4
  • Forkhead Box R1 Variant 1 3
  • Forkhead Box R1 Variant 2 3
  • Forkhead Box Protein R1 3
  • DLNB13 3

External Ids for FOXR1 Gene

Previous GeneCards Identifiers for FOXR1 Gene

  • GC11P118379
  • GC11P118347
  • GC11P118843
  • GC11P114782

Summaries for FOXR1 Gene

Entrez Gene Summary for FOXR1 Gene

  • This gene encodes a member of the forkhead box (FOX) family of transcription factors. FOX family members are monomeric, helix-turn-helix proteins with a core DNA-binding domain of approximately 110 aa. Many FOX transcription factors play roles in determining cell fates during early development. This forkhead box protein lacks the C-terminal basic region found in many other FOX family members. It is located within the 11q23.3 region which is commonly deleted in neuroblastomas. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXR1 Gene

FOXR1 (Forkhead Box R1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXR2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXR1 Gene

Genomics for FOXR1 Gene

Regulatory Elements for FOXR1 Gene

Enhancers for FOXR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F118906 1.9 FANTOM5 Ensembl ENCODE 12.2 -52.8 -52751 24.6 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC LOC101929133 RPS25 HINFP CCDC84 CXCR5 DPAGT1 UBE4A HMBS IFT46 ENSG00000222529
GH11F118868 1.6 FANTOM5 Ensembl ENCODE 11.2 -100.7 -100722 5.6 HDAC1 ATF1 PKNOX1 WRNIP1 SIN3A RAD21 ZBTB40 ETV6 CREM JUNB DDX6 CCDC84 TREHP1 UPK2 ENSG00000222529 FOXR1 BCL9L RN7SL688P ENSG00000255176 MIR6716
GH11F118819 1.3 Ensembl ENCODE 10.9 -150.3 -150282 3.8 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF143 LOC101929133 CXCR5 HINFP UPK2 ENSG00000222529 FOXR1 BCL9L RN7SL688P MIR6716 PHLDB1
GH11F119015 1.1 ENCODE 11.2 +46.5 46518 4.6 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 TRAPPC4 BCL9L ARCN1 ENSG00000254909 UBE4A RPS25 RPL23AP64 ENSG00000254428 ENSG00000222529 FOXR1
GH11F118787 1.1 ENCODE 10.9 -180.9 -180902 6.4 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 LOC105369519 CXCR5 LOC101929133 UPK2 ENSG00000222529 FOXR1 RPS25 BCL9L RN7SL688P C1QTNF5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FOXR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FOXR1 Gene

Chromosome:
11
Start:
118,971,543 bp from pter
End:
118,981,291 bp from pter
Size:
9,749 bases
Orientation:
Plus strand

Genomic View for FOXR1 Gene

Genes around FOXR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXR1 Gene

Proteins for FOXR1 Gene

  • Protein details for FOXR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PIV2-FOXR1_HUMAN
    Recommended name:
    Forkhead box protein R1
    Protein Accession:
    Q6PIV2
    Secondary Accessions:
    • B0YJ15
    • Q08AS8
    • Q86UT9
    • Q8IXX2

    Protein attributes for FOXR1 Gene

    Size:
    292 amino acids
    Molecular mass:
    33310 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FOXR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXR1 Gene

Post-translational modifications for FOXR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXR1 Gene

No data available for DME Specific Peptides for FOXR1 Gene

Domains & Families for FOXR1 Gene

Gene Families for FOXR1 Gene

Protein Domains for FOXR1 Gene

Suggested Antigen Peptide Sequences for FOXR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6PIV2

UniProtKB/Swiss-Prot:

FOXR1_HUMAN :
  • Contains 1 fork-head DNA-binding domain.
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXR1: view

Function for FOXR1 Gene

Gene Ontology (GO) - Molecular Function for FOXR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXR1: view
genes like me logo Genes that share phenotypes with FOXR1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FOXR1 Gene

Localization for FOXR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXR1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXR1 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1

Gene Ontology (GO) - Cellular Components for FOXR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with FOXR1: view

Pathways & Interactions for FOXR1 Gene

SuperPathways for FOXR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with FOXR1: view

No data available for Pathways by source and SIGNOR curated interactions for FOXR1 Gene

Transcripts for FOXR1 Gene

mRNA/cDNA for FOXR1 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXR1 Gene

Forkhead box R1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXR1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2: -

Relevant External Links for FOXR1 Gene

GeneLoc Exon Structure for
FOXR1
ECgene alternative splicing isoforms for
FOXR1

Expression for FOXR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FOXR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXR1 Gene

This gene is overexpressed in Testis (x42.2) and Ovary (x4.1).

Protein differential expression in normal tissues from HIPED for FOXR1 Gene

This gene is overexpressed in Fetal Liver (41.2) and Fetal gut (27.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FOXR1 Gene



Protein tissue co-expression partners for FOXR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FOXR1 Gene:

FOXR1

SOURCE GeneReport for Unigene cluster for FOXR1 Gene:

Hs.116679
genes like me logo Genes that share expression patterns with FOXR1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for FOXR1 Gene

Orthologs for FOXR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXR1 34 35
  • 99.43 (n)
cow
(Bos Taurus)
Mammalia LOC788135 34
  • 86.14 (n)
FOXR1 35
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXR1 34 35
  • 85.91 (n)
rat
(Rattus norvegicus)
Mammalia Foxr1 34
  • 80.05 (n)
mouse
(Mus musculus)
Mammalia Foxr1 34 16 35
  • 73.48 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 52 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 42 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii FOXR1 35
  • 30 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CHES-1-like 35
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5413 35
  • 7 (a)
OneToMany
Species where no ortholog for FOXR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXR1 Gene

ENSEMBL:
Gene Tree for FOXR1 (if available)
TreeFam:
Gene Tree for FOXR1 (if available)

Paralogs for FOXR1 Gene

Paralogs for FOXR1 Gene

(1) SIMAP similar genes for FOXR1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FOXR1: view

Variants for FOXR1 Gene

Sequence variations from dbSNP and Humsavar for FOXR1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10892318 -- 118,978,015(+) AGTTC(A/G)ACACC intron-variant
rs111286969 -- 118,972,142(+) CCCCC(G/T)ACGGC intron-variant
rs11217108 -- 118,971,051(+) AAAAA(C/T)AAAAT upstream-variant-2KB
rs112326280 -- 118,979,246(+) GTAGG(C/T)GAGGG intron-variant
rs113513127 -- 118,975,500(+) GCAGT(-/CTTGAGCAGC)CTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOXR1 Gene

Variant ID Type Subtype PubMed ID
nsv819166 CNV loss 19587683

Variation tolerance for FOXR1 Gene

Residual Variation Intolerance Score: 75.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXR1 Gene

Disorders for FOXR1 Gene

Relevant External Links for FOXR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXR1

No disorders were found for FOXR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXR1 Gene

Publications for FOXR1 Gene

  1. Identification and characterization of human FOXN5 and rat Foxn5 genes in silico. (PMID: 15067358) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 2 3 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Human FOX gene family (Review). (PMID: 15492844) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 3 22 64
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for FOXR1 Gene

Sources for FOXR1 Gene

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