FOXR1 Gene
protein-coding GIFtS : 46
GCID: GC11 P118843
forkhead box R1
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Aliasesfor FOXR1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Forkhead Box R1 1 2 FOXN51 2 3 Forkhead Box Protein N52 3 DLNB131 Forkhead Box Protein R12 Forkhead Box R1 Variant 12
Export aliases for FOXR1 gene to outside databases Previous GC identifers: GC11P118379 GC11P118347 GC11P114782
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Summariesfor FOXR1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for FOXR1 : This gene encodes a member of the forkhead box (FOX) family of transcription factors. FOX family members are monomeric, helix-turn-helix proteins with a core DNA-binding domain of approximately 110 aa. Many FOX transcription factors play roles in determining cell fates during early development. This forkhead box protein lacks the C-terminal basic region found in many other FOX family members. It is located within the 11q23.3 region which is commonly deleted in neuroblastomas. (provided by RefSeq, Jul 2008)
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Genomic Viewsfor FOXR1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_033899.8 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FOXR1 gene promoter: Spz1 RP58 AML1a MAZR p53 Roaz S8 deltaCREB SEF-1 (1) Pax-4a Other transcription factors Search SABiosciences Chromatin IP Primers for FOXR1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FOXR1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11q23.3 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23.3 FOXR1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11P118843: view genomic region
(about GC identifiers )
Start:
118,842,417 bp from pter
End:
118,852,001 bp from pter
Size:
9,585 bases
Orientation:
plus strand
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Proteinsfor FOXR1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: FOXR1_HUMAN, Q6PIV2 (See
protein sequence )Recommended Name: Forkhead box protein R1 Size : 292 amino acids; 33310 Da
Subcellular location : Nucleus (Probable)
Secondary accessions : B0YJ15 Q86UT9 Q8IXX2Explore the universe of human proteins at neXtProt for FOXR1: NX_Q6PIV2 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q6PIV2 FOXR1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_859072.1 ENSEMBL proteins: ENSP00000314806 ENSP00000433394 ENSP00000432358 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005667 transcription factor complex
IBA --
FOXR1 for ontologies About GeneDecksing FOXR1 Antibody Products: Assay Products for FOXR1:
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Protein
Domains / Familiesfor FOXR1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
FOXR1 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q6PIV2 ProtoNet protein and cluster: Q6PIV2
UniProtKB/Swiss-Prot: FOXR1_HUMAN, Q6PIV2 Similarity : Contains 1 fork-head DNA-binding domain
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Functionfor FOXR1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FOXR1 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FOXR1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FOXR1 (NM_181721 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOXR1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FOXR1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXR1
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003690 double-stranded DNA binding
IBA -- GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
IBA -- GO:0008134 transcription factor binding
IBA -- GO:0008301 DNA binding, bending
IBA -- GO:0043565 sequence-specific DNA binding
IEA --
FOXR1 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for FOXR1 :
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Pathways & Interactionsfor FOXR1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOXR1 Gene Ontology (GO): 5 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0007389 pattern specification process
IBA -- GO:0009790 embryo development
IBA -- GO:0009888 tissue development
IBA -- GO:0048513 organ development
IBA -- GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
IBA --
FOXR1 for ontologies About GeneDecksing
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Drugs & Compoundsfor FOXR1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for FOXR1 Search CenterWatch for drugs/clinical trials and news about FOXR1
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Transcriptsfor FOXR1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for FOXR1 gene: NM_181721.2 Unigene Cluster for FOXR1:
Forkhead box R1 Hs.116679 [show with all ESTs ] Unigene Representative Sequence: BC028191 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000317011 (uc001pui.3 uc001puk.3 ) ENST00000531539 (uc001puj.3 )ENST00000533282 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FOXR1 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FOXR1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FOXR1 (NM_181721 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOXR1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FOXR1
Additional cDNA sequence: AB094092.1 BC028191.1 BC038969.1 BC125040.1
1 DOTS entry : DT.100697249
13 AceView cDNA sequences :
NM_181721 AB094092 BI825543 BC028191 BC038969 AI638832 AI992357 BI830675 AI968909 AW589848 BX089058 AA669512 BC064340 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for FOXR1 About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 SP1 :             SP2 :       -      
ECgene alternative splicing isoforms for FOXR1
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Expression for FOXR1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section FOXR1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AGCCAGCCAG
About this image FOXR1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Ovary Antral Follicle Secondary Oocyte Female Gametocytes, Germ Cells Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See FOXR1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FOXR1 SOURCE GeneReport for Unigene cluster: Hs.116679 SABiosciences Custom PCR Arrays for FOXR1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FOXR1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat FOXR1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FOXR1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FOXR1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXR1
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Orthologsfor FOXR1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for FOXR1 gene from 3/14 species (see all 14 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
tropical clawed frog (Xenopus tropicalis)
Amphibia
AL853396.12
--
77.56(n)
 
AL853396.1
zebrafish (Danio rerio)
Actinopterygii
zgc:1717341
zgc:171734
51.1(n) 40.07(a)
 
570997 NM_001103124.1 NP_001096594.1
fruit fly (Drosophila melanogaster)
Insecta
fd3F6 Crg-16
Circadianly Regulated Gene
8(a) 16(a)
possible orthologpossible ortholog
X(3698218-3704546) X(3688900-3691372)
ENSEMBL Gene Tree for FOXR1 (if available)TreeFam Gene Tree for FOXR1 (if available)
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Paralogsfor FOXR1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for FOXR1 gene FOXR2 2 1 SIMAP similar gene for FOXR1 using alignment to 4 protein entries: FOXR1_HUMAN (see all proteins ):FOXR2
FOXR1 for paralogs About GeneDecksing
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Genomic Variantsfor FOXR1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 11 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for FOXR1 (118842417 - 118852001 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for FOXR1 1 CNV : 58497
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FOXR1
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Disorders
/ Diseasesfor FOXR1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
FOXR1 for disorders About GeneDecksing 2 diseases for FOXR1 : About MalaCards neuroblastoma hermaphroditism 2 Novoseek disease relationships for FOXR1 gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
hematologic malignancies
49.9
2
15289880 (1)
tumors
0
1
15067358 (1)
Export disorders for FOXR1 gene to outside databases
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Publicationsfor FOXR1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for FOXR1 gene, integrated from 9 sources (see all 11 ): (articles sorted by number of sources associating them with FOXR1) Utopia : connect your pdf to the dynamic world of online information
Identification and characterization of human FOXN5 and rat Foxn5 genes in silico. (PubMed id 15067358) 1 , 3, 9 Katoh M. and Katoh M. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Human FOX gene family (Review). (PubMed id 15492844) 1 , 9 Katoh M. and Katoh M. (2004) Oncogenic activation of FOXR1 by 11q23 intrachromosoma l deletion-fusions in neuroblastoma. (PubMed id 21860421) 1 Santo E.E....Molenaar J.J. (2012) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 2 Aoki H.... Hino O. (2000) Germ-line mutation of Foxn5 gene in mouse lineage. (PubMed id 15289901) 9 Katoh M. and Katoh M. (2004) Identification and characterization of human FOXK1 gene in silico. (PubMed id 15202027) 9 Katoh M. and Katoh M. (2004) Characterization of human FOXN4 gene in silico. (PubMed id 15492871) 9 Katoh M. and Katoh M. (2004) Identification and characterization of TMEM24 family genes in silico. (PubMed id 15289880) 9 Katoh M. and Katoh M. (2004)
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External Searches for FOXR1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing FOXR1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing FOXR1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing FOXR1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for FOXR1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for FOXR1 gene: Search GeneIP for patents involving FOXR1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor FOXR1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies Browse OriGene shRNA RFPs OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for FOXR1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FOXR1 OriGene Protein Over-expression Lysate for FOXR1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for FOXR1 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FOXR1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FOXR1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for FOXR1 OriGene Custom Protein Services for FOXR1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FOXR1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FOXR1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FOXR1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat FOXR1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FOXR1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FOXR1
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FOXR1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXR1
ThermoFisher Antibodies for FOXR1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FOXR1
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Aliases for FOXR1
Databases for FOXR1
Disorders / Diseases for FOXR1
Domains / Families for FOXR1
Drugs / Compounds for FOXR1
Expression for FOXR1
Function for FOXR1
Genomic Views for FOXR1
Intellectual Property for FOXR1
Orthologs for FOXR1
Paralogs for FOXR1
Pathways / Interactions for FOXR1
Products for FOXR1
Proteins for FOXR1
Publications for FOXR1
Search Box for FOXR1
Summaries for FOXR1
Transcripts for FOXR1
Variants for FOXR1
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