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Aliases for FOXQ1 Gene

Aliases for FOXQ1 Gene

  • Forkhead Box Q1 2 3 5
  • Hepatocyte Nuclear Factor 3 Forkhead Homolog 1 3 4
  • HNF-3/Forkhead-Like Protein 1 3 4
  • HFH-1 3 4
  • HFH1 3 4
  • Winged Helix/Forkhead Transcription Factor 3

External Ids for FOXQ1 Gene

Previous GeneCards Identifiers for FOXQ1 Gene

  • GC06P001302
  • GC06P001257

Summaries for FOXQ1 Gene

Entrez Gene Summary for FOXQ1 Gene

  • FOXQ1 is a member of the FOX gene family, which is characterized by a conserved 110-amino acid DNA-binding motif called the forkhead or winged helix domain. FOX genes are involved in embryonic development, cell cycle regulation, tissue-specific gene expression, cell signaling, and tumorigenesis (Bieller et al., 2001 [PubMed 11747606]).[supplied by OMIM, May 2009]

GeneCards Summary for FOXQ1 Gene

FOXQ1 (Forkhead Box Q1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXP3.

UniProtKB/Swiss-Prot for FOXQ1 Gene

  • Plays a role in hair follicle differentiation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXQ1 Gene

Genomics for FOXQ1 Gene

Regulatory Elements for FOXQ1 Gene

Enhancers for FOXQ1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FOXQ1 on UCSC Golden Path with GeneCards custom track

Promoters for FOXQ1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FOXQ1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FOXQ1 Gene

1,312,440 bp from pter
1,314,758 bp from pter
2,319 bases
Plus strand

Genomic View for FOXQ1 Gene

Genes around FOXQ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXQ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXQ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXQ1 Gene

Proteins for FOXQ1 Gene

  • Protein details for FOXQ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Forkhead box protein Q1
    Protein Accession:
    Secondary Accessions:
    • Q9NS06

    Protein attributes for FOXQ1 Gene

    403 amino acids
    Molecular mass:
    41526 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXQ1 Gene

Proteomics data for FOXQ1 Gene at MOPED

Post-translational modifications for FOXQ1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXQ1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXQ1 Gene

Domains & Families for FOXQ1 Gene

Gene Families for FOXQ1 Gene

Protein Domains for FOXQ1 Gene

Suggested Antigen Peptide Sequences for FOXQ1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 fork-head DNA-binding domain.
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXQ1: view

Function for FOXQ1 Gene

Molecular function for FOXQ1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in hair follicle differentiation.

Gene Ontology (GO) - Molecular Function for FOXQ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with FOXQ1: view
genes like me logo Genes that share phenotypes with FOXQ1: view

Animal Models for FOXQ1 Gene

MGI Knock Outs for FOXQ1:

Animal Model Products

Transcription Factor Targets for FOXQ1 Gene

Selected GeneGlobe predicted Target genes for FOXQ1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for FOXQ1 Gene

Localization for FOXQ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXQ1 Gene

Subcellular locations from

Jensen Localization Image for FOXQ1 Gene COMPARTMENTS Subcellular localization image for FOXQ1 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for FOXQ1 Gene

Pathways & Interactions for FOXQ1 Gene

SuperPathways for FOXQ1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXQ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030154 cell differentiation IBA --
GO:0031069 hair follicle morphogenesis IEA --
genes like me logo Genes that share ontologies with FOXQ1: view

No data available for Pathways by source and SIGNOR curated interactions for FOXQ1 Gene

Drugs & Compounds for FOXQ1 Gene

No Compound Related Data Available

Transcripts for FOXQ1 Gene

mRNA/cDNA for FOXQ1 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(47) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXQ1 Gene

Forkhead box Q1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXQ1 Gene

No ASD Table

Relevant External Links for FOXQ1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FOXQ1 Gene

mRNA expression in normal human tissues for FOXQ1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXQ1 Gene

This gene is overexpressed in Bladder (x7.7), Stomach (x6.9), Minor Salivary Gland (x5.6), Skin - Sun Exposed (Lower leg) (x4.7), and Skin - Not Sun Exposed (Suprapubic) (x4.5).

Protein differential expression in normal tissues from HIPED for FOXQ1 Gene

This gene is overexpressed in NK cells (60.4) and CD8 Tcells (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FOXQ1 Gene

SOURCE GeneReport for Unigene cluster for FOXQ1 Gene Hs.591352

mRNA Expression by UniProt/SwissProt for FOXQ1 Gene

Tissue specificity: Expressed predominantly in the stomach, trachea, bladder and salivary gland.
genes like me logo Genes that share expression patterns with FOXQ1: view

Protein tissue co-expression partners for FOXQ1 Gene

Primer Products

Orthologs for FOXQ1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXQ1 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Foxq1 35
  • 81.7 (n)
  • 78.84 (a)
Foxq1 16
Foxq1 36
  • 80 (a)
(Pan troglodytes)
Mammalia FOXQ1 35
  • 95.22 (n)
  • 93.08 (a)
FOXQ1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Foxq1 35
  • 82.37 (n)
  • 78.09 (a)
(Monodelphis domestica)
Mammalia FOXQ1 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 27 (a)
(Gallus gallus)
Aves -- 36
  • 37 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia foxq1 35
  • 58.44 (n)
  • 54.81 (a)
(Danio rerio)
Actinopterygii foxq1b 35
  • 64.55 (n)
  • 73.17 (a)
foxq1a 36
  • 51 (a)
foxq1b 36
  • 57 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2314 35
fruit fly
(Drosophila melanogaster)
Insecta bin 36
  • 14 (a)
(Caenorhabditis elegans)
Secernentea let-381 36
  • 20 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14119 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
Species with no ortholog for FOXQ1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FOXQ1 Gene

Gene Tree for FOXQ1 (if available)
Gene Tree for FOXQ1 (if available)

Paralogs for FOXQ1 Gene

genes like me logo Genes that share paralogs with FOXQ1: view

Variants for FOXQ1 Gene

Sequence variations from dbSNP and Humsavar for FOXQ1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs9502889 - 1,312,882(+) GAGAT(A/C)CGCAG reference, missense
rs9502890 - 1,312,886(+) TACGC(A/C)GGGCG reference, missense
rs1057567 -- 1,314,642(+) AGTGt(G/T)atttt utr-variant-3-prime
rs1057568 -- 1,314,643(+) GTGTG(A/T)ttttt utr-variant-3-prime
rs1064329 -- 1,314,649(+) ttttt(A/T)ttttt utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FOXQ1 Gene

Variant ID Type Subtype PubMed ID
nsv883369 CNV Gain 21882294
nsv823393 CNV Gain 20364138

Variation tolerance for FOXQ1 Gene

Gene Damage Index Score: 7.59; 82.57% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FOXQ1 Gene

Disorders for FOXQ1 Gene

Relevant External Links for FOXQ1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FOXQ1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXQ1 Gene

Publications for FOXQ1 Gene

  1. Isolation and characterization of the human forkhead gene FOXQ1. (PMID: 11747606) Bieller A. … Zoll B. (DNA Cell Biol. 2001) 2 3 4 23 67
  2. Transforming growth factor-beta 2 is a transcriptional target for Akt/protein kinase B via forkhead transcription factor. (PMID: 12011061) Samatar A.A. … Kumar C.C. (J. Biol. Chem. 2002) 2 3
  3. Double-negative feedback loop between microRNA-422a and forkhead box (FOX)G1/Q1/E1 regulates hepatocellular carcinoma tumor growth and metastasis. (PMID: 25251503) Zhang J. … Zhou W. (Hepatology 2015) 3
  4. PDGFRI+ and I^ play critical roles in mediating Foxq1-driven breast cancer stemness and chemoresistance. (PMID: 25502837) Meng F. … Wu G. (Cancer Res. 2015) 3
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3

Products for FOXQ1 Gene

Sources for FOXQ1 Gene