Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FOXP4 Gene

protein-coding GIFtS: 50
GCID: GC06P041514

forkhead box P4

Explore 5 diseases affiliated with
FOXP4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Forkhead Box P4¹ ²		Forkhead Box Protein P4²
Fork Head-Related Protein-Like A² ³		HFKHLA¹
FLJ40908¹		Winged-Helix Repressor FOXP4²
Fork Head-Related Protein Like A²		FKHLA³

External Ids:	HGNC: 20842¹	Entrez Gene: 116113²	Ensembl: ENSG00000137166⁷	OMIM: 608924⁵	UniProtKB: Q8IVH2³

Export aliases for FOXP4 gene to outside databases

Previous GC identifers: GC06P041515 GC06P041561 GC06P041622 GC06P041232

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FOXP4:

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription

factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both

development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles

in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx. Alternative

splicing of this gene produces multiple transcript variants, some encoding different isoforms. (provided by RefSeq,

Jul 2008)

UniProtKB/Swiss-Prot: FOXP4_HUMAN, Q8IVH2

Function: Transcriptional repressor that represses lung-specific expression (By similarity)

Gene Wiki entry for FOXP4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FOXP4 gene promoter:
Pbx1a Pax-5 NRSF form 1 FOXD1 FOXO3 CUTL1 FOXO3b Pax-3 Sox9 FOXO3a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FOXP4 promoter sequence

Search SABiosciences Chromatin IP Primers for FOXP4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXP4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p21.1

FOXP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXP4 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P041514: view genomic region (about GC identifiers)

Start:	41,514,164 bp from pter	End:	41,570,122 bp from pter
Size:	55,959 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FOXP4_HUMAN, Q8IVH2 (See protein sequence)

Recommended Name: Forkhead box protein P4

Size: 680 amino acids; 73488 Da

Subunit: Forms homodimers and heterodimers with FOXP1 and FOXP2. Dimerization is required for DNA-binding (By

similarity)

Subcellular location: Nucleus (Potential)

Secondary accessions: Q5W098 Q7Z7F8 Q8IW55 Q96E19

Alternative splicing: 3 isoforms: Q8IVH2-1 Q8IVH2-2 Q8IVH2-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FOXP4: NX_Q8IVH2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IVH2

FOXP4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001012426.1 NP_001012427.1 NP_612466.1

ENSEMBL proteins:

ENSP00000362154 ENSP00000386958 ENSP00000362148 ENSP00000309823 ENSP00000393704

ENSP00000362151

Human Recombinant Protein Products for FOXP4:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): FOXP4 OriGene Protein Over-expression Lysate: FOXP4 OriGene Custom Protein Services for FOXP4
	GenScript Custom Purified and Recombinant Proteins Services for FOXP4
	Novus Biologicals FOXP4 Proteins Novus Biologicals FOXP4 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for FOXP4

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005667	transcription factor complex	IBA	--
GO:0005737	cytoplasm	IBA	--

FOXP4 for ontologies About GeneDecksing

FOXP4 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for FOXP4
	Browse OriGene Antibodies OriGene Custom Antibody Services for FOXP4
	GenScript Custom Superior Antibodies Services for FOXP4
	Novus Biologicals FOXP4 Antibodies
	Abcam antibodies for FOXP4
	Uscn Antibodies for FOXP4
	ThermoFisher Antibodies for FOXP4

Assay Products for FOXP4:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FOXP4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FOXP4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FOXP4 for domains About GeneDecksing

4 InterPro domains/families:

IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

IPR015880 Znf_C2H2-like

IPR018122 TF_fork_head_CS

IPR001766 TF_fork_head

Graphical View of Domain Structure for InterPro Entry Q8IVH2

ProtoNet protein and cluster: Q8IVH2

UniProtKB/Swiss-Prot: FOXP4_HUMAN, Q8IVH2

Domain: The leucine-zipper is required for dimerization and transcriptional repression (By similarity)

Similarity: Contains 1 C2H2-type zinc finger

Similarity: Contains 1 fork-head DNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: FOXP4_HUMAN, Q8IVH2

Function: Transcriptional repressor that represses lung-specific expression (By similarity)

Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003682	chromatin binding	IBA	--
GO:0003690	double-stranded DNA binding	IBA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	--	--
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	IBA	--

FOXP4 for ontologies About GeneDecksing

Phenotypes:
7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Foxp4):

cardiovascular system	digestive/alimentary	embryogenesis	homeostasis/metabolism	mortality/aging
nervous system	respiratory system

FOXP4 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Foxp4^tm1Eem for FOXP4

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FOXP4

miRNA Products:		OriGene 3'-UTR Clone (see all 3): FOXP4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOXP4
		8/84 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXP4 (see all 84):
		hsa-miR-3607-3p hsa-miR-1321 hsa-miR-4254 hsa-miR-1914* hsa-miR-128 hsa-miR-30d hsa-miR-3916 hsa-miR-4267

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOXP4 (see all 6) OriGene siRNA: FOXP4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXP4
		Sirion Biotech Custom design and validation of potent shRNA sequences against FOXP4

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for FOXP4
			Sirion Biotech Customized adenovirus for overexpression of FOXP4 Sirion Biotech Customized adenovirus for potent knockdown of FOXP4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXP4 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXP4 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): FOXP4 (NM_138457)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXP4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXP4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FOXP4
		Search LifeMap BioReagents cell lines for FOXP4
		Sirion Biotech Customized stable knockdown cell line services for FOXP4 Sirion Biotech Customized inducible knockdown cell line services for FOXP4 Sirion Biotech Customized stable overexpressing cell line services for FOXP4 Sirion Biotech Customized inducible overexpressing cell line services for FOXP4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXP4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FOXP4

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5 Interacting proteins for FOXP4 (Q8IVH2³ ENSP00000309823⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FOXP1	Q9H334³, ENSP00000318902⁴	I2D: score=2 STRING: ENSP00000318902
FOXP2	O15409³, ENSP00000386200⁴	I2D: score=2 STRING: ENSP00000386200
POU5F1	Q01860³	I2D: score=1
SUMO2	ENSP00000405965⁴	STRING: ENSP00000405965
DEGS1	ENSP00000316476⁴	STRING: ENSP00000316476

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	--	--
GO:0007389	pattern specification process	IBA	--
GO:0007507	heart development	IBA	--
GO:0009888	tissue development	IBA	--
GO:0048617	embryonic foregut morphogenesis	IBA	--

FOXP4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FOXP4
Search CenterWatch for drugs/clinical trials and news about FOXP4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FOXP4 gene (3 alternative transcripts):

NM_001012426.1 NM_001012427.1 NM_138457.2

Unigene Cluster for FOXP4:

Forkhead box P4

Hs.131436 [show with all ESTs]

Unigene Representative Sequence: NM_001012426

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000373063(uc003oqn.3) ENST00000409208 ENST00000373057 ENST00000307972

ENST00000451305 ENST00000373060(uc003oql.3 uc003oqm.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 3): FOXP4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOXP4
		8/84 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXP4 (see all 84):
		hsa-miR-3607-3p hsa-miR-1321 hsa-miR-4254 hsa-miR-1914* hsa-miR-128 hsa-miR-30d hsa-miR-3916 hsa-miR-4267

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOXP4 (see all 6) OriGene siRNA: FOXP4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXP4
		Sirion Biotech Custom design and validation of potent shRNA sequences against FOXP4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXP4 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXP4 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): FOXP4 (NM_138457)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXP4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXP4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOXP4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FOXP4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXP4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXP4

Additional cDNA sequence:

AB080747.1 AK094912.1 AK098227.1 AL832437.1 BC009628.1 BC013030.2 BC016874.1 BC034931.1

BC040962.1 BC052803.1 DQ656018.2

4 DOTS entries:

DT.423434 DT.40127073 DT.86842297 DT.92061858

24/131 AceView cDNA sequences (see all 131):

AW027840 NM_138457 CD367512 AK098227 BM725203 BQ083048 BU526523 BC009628

BC052803 BC013030 BC040962 AW504781 AL832437 BQ680336 BC016874 AI499223

BM678216 BE464888 BC034931 BM470031 BM479242 BQ955173 AW779127 AA961116

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for FOXP4 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b
SP1:																					-
SP2:
SP3:

ECgene alternative splicing isoforms for FOXP4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FOXP4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTCCCCAC

About this image

FOXP4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Limb Bud

Limb Bud Mesenchyme Cells

Mesoderm

Limb

Autopod

Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FOXP4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FOXP4

SOURCE GeneReport for Unigene cluster: Hs.131436

SABiosciences Custom PCR Arrays for FOXP4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOXP4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FOXP4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXP4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXP4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXP4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FOXP4 gene from 4/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC100858652¹	forkhead box protein P4-like	79.1(n) 82.93(a)		100858652 XM_003642748.1 XP_003642796.1
lizard (Anolis carolinensis)	Reptilia	FOXP4⁶	--	75(a)	1 ↔ 1	4(119882293-119945945)
zebrafish (Danio rerio)	Actinopterygii	foxp4¹	forkhead box P4	71.64(n) 75.34(a)		557245 NM_001199491.1 NP_001186420.1
worm (Caenorhabditis elegans)	Secernentea	fkh-9⁶	ForKHead transcription factor family member (fkh-9...	12(a)	possible ortholog	X(3817407-3826944)

ENSEMBL Gene Tree for FOXP4 (if available)
TreeFam Gene Tree for FOXP4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FOXP4 gene

FOXJ1² FOXN3² FOXK1² FOXN4² FOXN1² FOXK2² FOXG1² FOXJ3²

FOXJ2² FOXP2² FOXN2² FOXP3² FOXP1²

6 SIMAP similar genes for FOXP4 using alignment to 5 protein entries: FOXP4_HUMAN (see all proteins):

DKFZp762O213 hFKHLB DKFZp686H1726 FOXP1 FOXP2 FOXP3

FOXP4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188180996^1,2		--	41512278(+)	`ACTACA/CAAGGG`	3	--	us2k¹		0	--	--	--	--
rs1326322^1,2	C,F,A	--	41512462(+)	`CCTCAG/TTTTCC`	3	--	us2k¹		8		NA WA CSA EA	367
rs1326323^1,2	C,F,A	--	41512497(+)	`AAATAT/GCTCCC`	3	--	us2k¹ trp³		6		NA WA CSA EA	364
rs115670379^1,2	F	--	41512669(+)	`ACCTAG/CAAATC`	3	--	us2k¹		1		NA	120
rs72858927^1,2	C	--	41512681(+)	`AAAACG/CCTCCA`	3	--	us2k¹		3		CSA WA NA	239
rs180800028^1,2		--	41512818(+)	`TCCTCC/TCTGAG`	3	--	us2k¹		0	--	--	--	--
rs146958188^1,2		--	41513078(+)	`CACTGA/CGCTGG`	3	--	us2k¹		0	--	--	--	--
rs73733272^1,2	C	--	41513133(+)	`CCCACC/TCCCAA`	3	--	us2k¹		2		WA	120
rs115875188^1,2	F	--	41513370(+)	`CGCGGG/TGTTTT`	3	--	us2k¹		1		WA	118
rs186442603^1,2		--	41513504(+)	`CAGAGC/GGAGGC`	3	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FOXP4 (41514164 - 41570122 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FOXP4
1 CNV: 59341
1 Indel: 69496

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOXP4

DNA2.0 Custom Variant and Variant Library Synthesis for FOXP4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FOXP4 for disorders           About GeneDecksing

OMIM gene information: 608924    OMIM disorders: --

5 diseases for FOXP4:    About MalaCards

hepatitis b hermaphroditism prostate cancer hepatitis

prostatitis

Human Genome Epidemiology (HuGE) Navigator: FOXP4 (5 documents)

Export disorders for FOXP4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FOXP4 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with FOXP4)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Replication and fine mapping for association of the C2 orf43, FOXP4, GPRC6A and RFX6 genes with prostate cancer in the Chinese populati on. (PubMed id 22662242)¹ Long Q.Z....Liu X.G. (2012)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)¹ Tatham M.H....Hay R.T. (2011)
New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)¹ Davila S....Seielstad M. (2010)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
Genome-wide association study identifies five new sus ceptibility loci for prostate cancer in the Japanese population. (PubMed id 20676098)¹ Takata R....Nakagawa H. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)¹ Golebiowski F....Hay R.T. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 116113	HGNC: 20842	AceView: FOXP4	Ensembl:ENSG00000137166	euGenes: HUgn116113
ECgene: FOXP4	H-InvDB: FOXP4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FOXP4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FOXP4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FOXP4 gene:
Search GeneIP for patents involving FOXP4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for FOXP4 (FoxP4)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		Browse OriGene shRNA RFPs
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOXP4		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOXP4
	OriGene Protein Over-expression Lysate for FOXP4		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for FOXP4		OriGene 3'-UTR Clone for FOXP4
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXP4		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXP4
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for FOXP4		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for FOXP4		OriGene Custom Protein Services for FOXP4
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FOXP4
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOXP4
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXP4
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXP4
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXP4
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXP4

	GenScript Custom Purified and Recombinant Proteins Services for FOXP4		GenScript cDNA clones with any tag delivered in your preferred vector for FOXP4
	GenScript Custom Assay Services for FOXP4		GenScript Custom Superior Antibodies Services for FOXP4
	GenScript Custom overexpressing Cell Line Services for FOXP4		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in FOXP4 promoter
	Search Chromatin IP Primers for FOXP4
	RT² qPCR Primer Assay in human, mouse, rat FOXP4
	Search GNC Networks for FOXP4
	SABiosciences Custom PCR Arrays for FOXP4

Search Tocris compounds for FOXP4

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	FOXP4 antibodies
	FOXP4 proteins
	FOXP4 lysates

	Antibodies for FOXP4
	See all of Abcam's Antibodies, Kits and Proteins for FOXP4
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

FOXP4 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for FOXP4

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXP4

	Browse SwitchGear 3'UTR luciferase reporter plasmids for FOXP4
	SwitchGear Promoter luciferase reporter plasmids for FOXP4

ThermoFisher Antibodies for FOXP4

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXP4

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FOXP4

Sirion Biotech Customized:

	stable knockdown cell line services for FOXP4
	inducible knockdown cell line services for FOXP4
	design and validation of potent shRNA sequences against FOXP4
	adenovirus for potent knockdown of FOXP4
	adenovirus for overexpression of FOXP4
	stable overexpressing cell line services for FOXP4
	inducible overexpressing cell line services for FOXP4

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes FOXP4 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

FOXP4 Gene

forkhead box P4

Aliases
for FOXP4 gene

Summaries
for FOXP4 gene

Genomic Views
for FOXP4 gene

Proteins
for FOXP4 gene

Protein Domains /
Families
for FOXP4 gene

Function
for FOXP4 gene

Pathways & Interactions
for FOXP4 gene

Drugs & Compounds
for FOXP4 gene

Transcripts
for FOXP4 gene

Expression
for FOXP4 gene

Orthologs
for FOXP4 gene

Paralogs
for FOXP4 gene

Genomic Variants
for FOXP4 gene

Disorders / Diseases
for FOXP4 gene

Publications
for FOXP4 gene

External Searches for FOXP4 gene

Genome Databases showing FOXP4 gene

Other Databases showing FOXP4 gene

Specialized Databases showing FOXP4 gene

Intellectual Property
for FOXP4 gene

Products
for FOXP4 gene

View Random Gene

Advanced Search

Export list of displayed genes

FOXP4 Gene

forkhead box P4

Aliasesfor FOXP4 gene

Summariesfor FOXP4 gene

Genomic Viewsfor FOXP4 gene

Proteinsfor FOXP4 gene

Protein Domains /Familiesfor FOXP4 gene

Functionfor FOXP4 gene

Pathways & Interactionsfor FOXP4 gene

Drugs & Compoundsfor FOXP4 gene

Transcriptsfor FOXP4 gene

Expression for FOXP4 gene

Orthologsfor FOXP4 gene

Paralogsfor FOXP4 gene

Genomic Variantsfor FOXP4 gene

Disorders / Diseasesfor FOXP4 gene

Publicationsfor FOXP4 gene

External Searches for FOXP4 gene

Genome Databases showing FOXP4 gene

Other Databases showing FOXP4 gene

Specialized Databases showing FOXP4 gene

Intellectual Propertyfor FOXP4 gene

Productsfor FOXP4 gene

View Random Gene

Aliases
for FOXP4 gene

Summaries
for FOXP4 gene

Genomic Views
for FOXP4 gene

Proteins
for FOXP4 gene

Protein Domains /
Families
for FOXP4 gene

Function
for FOXP4 gene

Pathways & Interactions
for FOXP4 gene

Drugs & Compounds
for FOXP4 gene

Transcripts
for FOXP4 gene

Expression
for FOXP4 gene

Orthologs
for FOXP4 gene

Paralogs
for FOXP4 gene

Genomic Variants
for FOXP4 gene

Disorders / Diseases
for FOXP4 gene

Publications
for FOXP4 gene

Intellectual Property
for FOXP4 gene

Products
for FOXP4 gene