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FOXP4 Gene

protein-coding   GIFtS: 53
GCID: GC06P041514

Forkhead Box P4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Forkhead Box P41 2     hFKHLA2
Fork Head-Related Protein-Like A2 3     Winged-Helix Repressor FOXP42
Fork Head-Related Protein Like A2     FKHLA3
Forkhead Box Protein P42     

External Ids:    HGNC: 208421   Entrez Gene: 1161132   Ensembl: ENSG000001371667   OMIM: 6089245   UniProtKB: Q8IVH23   

Export aliases for FOXP4 gene to outside databases

Previous GC identifers: GC06P041515 GC06P041561 GC06P041622 GC06P041232


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FOXP4 Gene:
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription
factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both
development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have
roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx.
Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.
(provided by RefSeq, Jul 2008)

GeneCards Summary for FOXP4 Gene:
FOXP4 (forkhead box P4) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOXP2.

UniProtKB/Swiss-Prot: FOXP4_HUMAN, Q8IVH2
Function: Transcriptional repressor that represses lung-specific expression (By similarity)

Gene Wiki entry for FOXP4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FOXP4 gene promoter:
         Pbx1a   Pax-5   NRSF form 1   FOXD1   FOXO3   CUTL1   FOXO3b   Pax-3   Sox9   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOXP4 promoter sequence
   Search Chromatin IP Primers for FOXP4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FOXP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

FOXP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXP4 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P041514:  view genomic region     (about GC identifiers)

Start:
41,514,164 bp from pter      End:
41,570,122 bp from pter
Size:
55,959 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FOXP4_HUMAN, Q8IVH2 (See protein sequence)
Recommended Name: Forkhead box protein P4  
Size: 680 amino acids; 73488 Da
Subunit: Forms homodimers and heterodimers with FOXP1 and FOXP2. Dimerization is required for DNA-binding (By
similarity)
Secondary accessions: Q5W098 Q7Z7F8 Q8IW55 Q96E19
Alternative splicing: 3 isoforms:  Q8IVH2-1   Q8IVH2-2   Q8IVH2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FOXP4: NX_Q8IVH2

Explore proteomics data for FOXP4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys175, Lys532
  • Modification sites at PhosphoSitePlus

  • See FOXP4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001012426.1  NP_001012427.1  NP_612466.1  

    ENSEMBL proteins: 
     ENSP00000362154   ENSP00000386958   ENSP00000362148   ENSP00000309823   ENSP00000393704  
     ENSP00000362151  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FOX: Forkhead boxes

    4 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR015880 Znf_C2H2-like
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry Q8IVH2

    ProtoNet protein and cluster: Q8IVH2

    UniProtKB/Swiss-Prot: FOXP4_HUMAN, Q8IVH2
    Domain: The leucine-zipper is required for dimerization and transcriptional repression (By similarity)
    Similarity: Contains 1 C2H2-type zinc finger
    Similarity: Contains 1 fork-head DNA-binding domain


    Find genes that share domains with FOXP4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOXP4_HUMAN, Q8IVH2
    Function: Transcriptional repressor that represses lung-specific expression (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0042803protein homodimerization activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with FOXP4           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Foxp4):
     cardiovascular system  digestive/alimentary  embryogenesis  homeostasis/metabolism  mortality/aging 
     nervous system  respiratory system 

    Find genes that share phenotypes with FOXP4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Foxp4tm1Eem for FOXP4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FOXP4
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    miRNA
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    miRTarBase miRNAs that target FOXP4:
    hsa-mir-128-3p (MIRT022091), hsa-mir-101-3p (MIRT027329), hsa-mir-186-5p (MIRT021115), hsa-mir-27a-3p (MIRT028722)

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    Selected qRT-PCR Assays for microRNAs that regulate FOXP4 (see all 84):
    hsa-miR-3607-3p hsa-miR-1321 hsa-miR-4254 hsa-miR-1914* hsa-miR-128 hsa-miR-30d hsa-miR-3916 hsa-miR-4267
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXP4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FOXP4_HUMAN, Q8IVH2: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with FOXP4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FOXP4
    Interactions:

        Search GeneGlobe Interaction Network for FOXP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for FOXP4 (Q8IVH23 ENSP000003098234) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206454Q018603I2D: score=1 
    ENSG00000229094Q018603I2D: score=1 
    ENSG00000230336Q018603I2D: score=1 
    ENSG00000233911Q018603I2D: score=1 
    ENSG00000235068Q018603I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007507heart development IEA--
    GO:0048617embryonic foregut morphogenesis IEA--
    GO:0061140lung secretory cell differentiation IEA--

    Find genes that share ontologies with FOXP4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FOXP4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FOXP4 gene (3 alternative transcripts): 
    NM_001012426.1  NM_001012427.1  NM_138457.2  

    Unigene Cluster for FOXP4:

    Forkhead box P4
    Hs.131436  [show with all ESTs]
    Unigene Representative Sequence: NM_001012426
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373063(uc003oqn.3) ENST00000409208 ENST00000373057 ENST00000307972
    ENST00000451305 ENST00000373060(uc003oql.3 uc003oqm.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FOXP4 (see all 84):
    hsa-miR-3607-3p hsa-miR-1321 hsa-miR-4254 hsa-miR-1914* hsa-miR-128 hsa-miR-30d hsa-miR-3916 hsa-miR-4267
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    Additional mRNA sequence: 

    AB080747.1 AK094912.1 AK098227.1 AL832437.1 BC009628.1 BC013030.2 BC016874.1 BC034931.1 
    BC040962.1 BC052803.1 DQ656018.2 

    4 DOTS entries:

    DT.423434  DT.40127073  DT.86842297  DT.92061858 

    Selected AceView cDNA sequences (see all 131):

    AW504781 CB106530 BM470031 AW779127 BM479242 AW027840 AK098227 BM725203 
    NM_138457 BC034931 BC009628 BG925113 BM678216 BE464888 BU526523 AL832437 
    BC052803 BC016874 BC013030 BQ083048 BQ955173 CD367512 AI499223 CR612831 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FOXP4    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
    SP1:                                                              -                                                   
    SP2:                                                                                                                  
    SP3:                                                                                                                  


    ECgene alternative splicing isoforms for FOXP4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FOXP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTCCCCAC
    FOXP4 Expression
    About this image


    FOXP4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Thalamus
             Substantia Nigra   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Limb Bud Mesenchyme Cells Limb Bud
             Autopod
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
     
     Neural Tube (Nervous System)
             Metencephalon
    FOXP4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FOXP4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.131436
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FOXP4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Foxp41 , 5 forkhead box P41, 5 88.24(n)1
    93.59(a)1
      17 (23.99 cM)5
    741231  NM_001110824.11  NP_001104294.11 
     478671335 
    chicken
    (Gallus gallus)
    Aves LOC1008586521 forkhead box protein P4-like 79.04(n)
    82.84(a)
      100858652  XM_004948416.1  XP_004948473.1 
    lizard
    (Anolis carolinensis)
    Reptilia FOXP46
    forkhead box P4
    77(a)
    1 ↔ 1
    4(119882293-119988571)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia foxp41 forkhead box P4 68.65(n)
    77.21(a)
      768088  NM_001077187.2  NP_001070655.1 
    zebrafish
    (Danio rerio)
    Actinopterygii foxp41 forkhead box P4 71.88(n)
    75.43(a)
      557245  NM_001199491.1  NP_001186420.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta FoxP6
    Forkhead box P
    33(a)
    1 → many
    3R(5551742-5555165)
    worm
    (Caenorhabditis elegans)
    Secernentea fkh-76
    fkh-86
    Protein FKH-7, isoform a (fkh-7) mRNA, complete cd...
    Protein FKH-8, isoform a (fkh-8) mRNA, complete cd...
    24(a)
    23(a)
    many ↔ many
    many ↔ many
    IV(5584661-5610364) WBGene00001439
    II(6189580-6191402) WBGene00001440


    ENSEMBL Gene Tree for FOXP4 (if available)
    TreeFam Gene Tree for FOXP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FOXP4 gene
    FOXP22  FOXP32  FOXP12  
    7 SIMAP similar genes for FOXP4 using alignment to 5 protein entries:     FOXP4_HUMAN (see all proteins):
    DKFZp762O213    hFKHLB    DKFZp686H1726    FOXP1    FOXP2    FOXN4
    FOXP3

    Find genes that share paralogs with FOXP4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FOXP4 (see all 1067)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362194
    A breast cancer sample4--see VAR_0362192 A T mis40--------
    rs69354461,2
    C,F--41514372(+) AAGGAA/GGAGCG 3 -- ut51 trp31Minor allele frequency- G:0.23NA 120
    rs69357371,2
    C,F--41514411(+) AGTGCC/GATGCC 3 -- ut511Minor allele frequency- G:0.14NA 120
    rs1995636531,2
    C--41515180(+) AGAGA-/CGGGGG 3 -- int10--------
    rs1502731641,2
    C--41515515(+) CAGGA-/CCCCCC 3 -- int10--------
    rs2019130181,2
    --41515522(+) CCCCC-/CACCGCC 3 -- int10--------
    rs1436987401,2
    C--41516286(+) GTATG-/GC    
       CTGTA
    GCTGC
    3 -- int10--------
    rs743978151,2
    C,F--41517448(+) GGGTAG/AGAGAG 3 -- int11Minor allele frequency- A:0.22EA 120
    rs122068141,2
    C,A--41517457(+) AGACAC/GATATC 3 -- int16Minor allele frequency- G:0.43NA EA 248
    rs1883796501,2
    C--41517468(+) ACATGG/TTGGGG 3 -- int10--------

    HapMap Linkage Disequilibrium report for FOXP4 (41514164 - 41570122 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FOXP4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678648CNV Deletion23128226
    esv28388CNV Loss19812545
    nsv885830CNV Loss21882294
    nsv819316CNV Gain19587683

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608924    OMIM disorders: --


    Find genes that share disorders with FOXP4           About GenesLikeMe

    Genetic Association Database (GAD): FOXP4
    Human Genome Epidemiology (HuGE) Navigator: FOXP4 (5 documents)

    Export disorders for FOXP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FOXP4 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with FOXP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. (PubMed id 20676098)1, 4 Takata R....Nakagawa H. (Nat. Genet. 2010)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Foxp4 is dispensable for T cell development, but required for robust recall responses. (PubMed id 22912696)1 Wiehagen K.R....Maltzman J.S. (PLoS ONE 2012)
    7. Replication and fine mapping for association of the C2orf43, FOXP4, GPRC6A and RFX6 genes with prostate cancer in the Chinese population. (PubMed id 22662242)1 Long Q.Z....Liu X.G. (PLoS ONE 2012)
    8. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Comparative proteomic analysis identifies a role for SUMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (Sci Signal 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 116113 HGNC: 20842 AceView: FOXP4 Ensembl:ENSG00000137166 euGenes: HUgn116113
    ECgene: FOXP4 H-InvDB: FOXP4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FOXP4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FOXP4 gene:
    Search GeneIP for patents involving FOXP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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