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FOXP3 Gene

protein-coding GIFtS: 57

GC0XM048993

forkhead box P3
(Previous names: immune dysregulation, polyendocrinopathy, enteropathy, X-linked )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: IPEX)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AIID ^¹, ², ⁵
DIETER ^¹, ²
IPEX ^², ³, ⁵
JM2 ^¹, ²
MGC141961 ^²
MGC141963 ^²
OTTHUMP00000025832 ^²
PIDX ^¹, ², ⁵
SCURFIN ^¹
Scurfin ^³
XPID ^¹, ², ⁵
scurfin ^²

Descriptions
forkhead box P3 ^²
immune dysregulation, polyendocrinopathy, enteropathy, X-linked ^¹, ²
immunodeficiency, polyendocrinopathy, enteropathy, X-linked ^²

External Ids
HGNC: 6106¹
Entrez Gene: 50943²
UniProtKB: Q9BZS1³
Ensembl: ENSG00000049768⁷

Search outside databases for aliases for FOXP3 gene

Previous GC identifers: GC0XM047890 GC0XM047348 GC0XM047913 GC0XM048133 GC0XM048863

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FOXP3:

The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional

regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy,

enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency

syndrome. Alternatively spliced transcript variants encoding different isoforms have been

identified. [provided by RefSeq]

UniProtKB/Swiss-Prot: FOXP3_HUMAN, Q9BZS1

Function: Probable transcription factor. Plays a critical role in the control of immune response

Gene Wiki entry for FOXP3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FOXP3 gene

Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23

FOXP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM048993: (about GC identifiers)

Start:	48,994,354 bp from pter
End:	49,008,232 bp from pter
Size:	13,879 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000023.9 NT_079573.3

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: FOXP3_HUMAN, Q9BZS1 (See protein sequence)

Recommended Name: Forkhead box protein P3

Size: 431 amino acids; 47244 Da

Subcellular location: Nucleus (Potential)

Secondary accessions: A5HJT1 O60827 Q14DD8 Q4ZH51

Alternative splicing: 3 isoforms: Q9BZS1-1 Q9BZS1-2 Q9BZS1-3

REFSEQ proteins (2 alternative transcripts):

NP_001107849.1 NP_054728.2

ENSEMBL proteins:

ENSP00000365380 ENSP00000365372 ENSP00000365369

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (FOXP3, FOXP3 (exon 2 deleted))
	Human Recombinant Proteins from Abnova (FOXP3)

OriGene Purified Recombinant Human Protein: FOXP3

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IDA	11483607 16873067 16920951
GO:0043234	protein complex	NAS	16903909

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Antibodies for FOXP3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for FOXP3
	R&D Systems Antibodies for FOXP3
	Antibodies from Abcam (FOXP3, FOXP3 (exon 2 deleted)), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FOXP3)
	Novus Biologicals Antibodies for FOXP3

Assays for FOXP3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9BZS1

ProtoNet protein and cluster: Q9BZS1

UniProtKB/Swiss-Prot: FOXP3_HUMAN, Q9BZS1

Similarity: Contains 1 C2H2-type zinc finger

Similarity: Contains 1 fork-head DNA-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FOXP3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FOXP3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_014009

Applied Biosystems Silencer® siRNAs for FOXP3

Sigma-Aldrich siRNA for FOXP3

Sigma-Aldrich shRNA Panels and shRNA for FOXP3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FOXP3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001114377
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001114377
untagged cDNA clones in CMV expression vector (see all 3): NM_001114377

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_014009

UniProtKB/Swiss-Prot: FOXP3_HUMAN, Q9BZS1

Function: Probable transcription factor. Plays a critical role in the control of immune response

15/21 MGI mutant phenotypes (inferred from 15 alleles) (MGI details for Foxp3) (see all 21 ):

	behavior/neurological	craniofacial	digestive/alimentary	endocrine/exocrine gland
growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system
lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	liver/biliary system	no phenotypic analysis

5/9 Gene Ontology (GO) molecular function terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	NAS	11138001
GO:0005515	protein binding	IPI	16652169
GO:0008270	zinc ion binding	IEA	--
GO:0016565	general transcriptional repressor activity	IDA	16920951
GO:0042803	protein homodimerization activity	IPI	16920951

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for FOXP3

5/84 Interacting proteins for FOXP3 (ENSP00000365369³) via UniProtKB, MINT, and/or STRING (see all 84 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL2	ENSP00000226730³	STRING (score=.999)
IL2RA	ENSP00000369293³	STRING (score=.997)
CD4	ENSP00000011653³	STRING (score=.994)
CTLA4	ENSP00000303939³	STRING (score=.994)
IL17A	ENSP00000344192³	STRING (score=.992)

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5/17 Gene Ontology (GO) biological process terms (links to tree view) (see all 17 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002725	negative regulation of T cell cytokine production	IDA	15466453
GO:0006338	chromatin remodeling	NAS	16903909
GO:0008285	negative regulation of cell proliferation	IDA	15652505
GO:0032088	negative regulation of NF-kappaB transcription factor activity	IDA	16652169
GO:0032689	negative regulation of interferon-gamma production	IDA	15466453

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FOXP3
2 Novoseek chemical compound relationships for FOXP3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tgf beta1	21.46	1	15249539 (1)
p003	0.00	1	16003241 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FOXP3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FOXP3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_014009

Sigma-Aldrich siRNA for FOXP3

Sigma-Aldrich shRNA Panels and shRNA for FOXP3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001114377 NM_014009

REFSEQ mRNAs for FOXP3 gene (2 alternative transcripts):

NM_001114377.1 NM_014009.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001114377 NM_014009

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001114377
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001114377
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001114377

Additional cDNA sequence:

AF277993.1 AK292052.1 AK299988.1 BC113401.1 BC113403.1 BC143785.1 BC143786.1 DQ010327.1

EF534714.1 EU855812.1

3 DOTS entries:

DT.95248575 DT.121322321 DT.100736036

6 AceView cDNA sequences:

BM832990 AJ005891 NM_014009 AF277993 BP338852 BM918693

highest scoring ESTs for FOXP3:

AF277993 BM832990 AJ005891 BM918693 BP338852 NM_014009 DA957960 DA959086 DB104925 DQ010327

Unigene Cluster for FOXP3:

Forkhead box P3

Hs.247700 [show with all ESTs]

Unigene Representative Sequence: NM_014009

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for FOXP3

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b
SP1:
SP2:											-
SP3:											-
SP4:											-
SP5:											-		-

About this scheme

ECgene alternative splicing isoforms for FOXP3

3 Ensembl transcripts including schematic representations:

ENST00000376207 ENST00000376199 ENST00000376197

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FOXP3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FOXP3

¹ / ² / ³

6 probe-sets matching FOXP3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
224211_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF277993	0.80	1.00	0.91	1
221333_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_014009	0.60	1.00	0.82	1
221334_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_014009	0.60	1.00	0.82	1
224211_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
221333_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
221334_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.247700

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FOXP3 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FOXP3¹	--	forkhead box P3	89.61(n) 90.93(a)	491876 XM_548996.2 XP_548996.2
chimpanzee (Pan troglodytes)	FOXP3¹	--	forkhead box P3	99.2(n) 98.8(a)	740909 XM_001143169.1 XP_001143169.1
cow (Bos taurus)	FOXP3¹	--	forkhead box P3	89.25(n) 90.02(a)	506053 NM_001045933.1 NP_001039398.1
rat (Rattus norvegicus)	Foxp3¹	--	forkhead box P3	84.3(n) 86.48(a)	317382 XM_228771.4 XP_228771.4
mouse (Mus musculus)	Foxp3^{1, 5}	X (2.10 cM)⁵	forkhead box P3^{1, 5}	85.05(n)¹ 86.92(a)¹	20371¹ NM_054039.1¹ NP_473380.1¹ AF277991⁵ AF277992⁵ (see all 15)

About this table Species with no ortholog for FOXP3

ENSEMBL Gene Tree for FOXP3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FOXP3 gene

FOXJ3² FOXJ2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/85 NCBI SNPs in FOXP3 are shown (see all 85 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 26)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs11091253^1,2	C,F	49008970(-)	`CCTTCC/TCAGTG`	1	--	ng3¹		4		NA EU	184
--	rs2232369^1,2	H	48999196(-)	`CCAGGC/TGGACC`	2	A/V	mis¹ ese³		4		EU EA WA	390
--	rs6608853^1,2	A	49009858(+)	`CCCTTC/TTGGAA`	1	--	ng3¹ tfbs³		0	--	--	--	--
--	rs6608851^1,2	A	49009807(+)	`ACCTTC/TTAAGC`	1	--	ng3¹		0	--	--	--	--
--	rs2232367^1,2	C,F	49000256(-)	`CCCAGC/TACCCT`	2	S/S	syn¹ ese³		3		NA EU	90
	rs3761547^1,2	A,C,F,H	49005405(-)	`GGGCAA/GTTGTC`	1	--	int¹		15		NA EU EA WA	1082
	rs3761549^1,2	A,C,F,H	49004289(-)	`GCAGCC/TAGTTC`	1	--	int¹		7		EU EA WA NA	510
	rs6609859^1,2	A,C,F,H	49006610(+)	`CCAATG/AAATAG`	1	--	int¹		11		EU EA WA NA	737
	rs3761548^1,2	C,F,H	49005185(-)	`AACTGC/AAGGCC`	1	--	int¹		11		EU EA WA NA	822
	rs2280883^1,2	C,F,H	48996072(+)	`GGGAAT/CGGTGC`	1	--	int¹		11		NA EU EA WA	722

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HapMap Linkage Disequilibrium images for FOXP3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300292 disorders: 304790 222100

UniProtKB/Swiss-Prot: FOXP3_HUMAN, Q9BZS1

Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy,

X-linked syndrome (IPEX) [MIM:304790]; also known as X-linked autoimmunity-immunodeficiency

syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections,

secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy

10/27 Novoseek disease relationships for FOXP3 gene (see all 27 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
polyendocrinopathies autoimmune	73.35	5	19122524 (2), 16682278 (1), 15703687 (1)
autoimmune diseases	68.39	13	16920951 (1), 16216670 (1), 16741580 (1), 15912097 (1) (see all 10)
autoimmunity	63.06	12	16682278 (1), 16741580 (1), 18317533 (1), 18626575 (1) (see all 9)
paraparesis tropical spastic	38.03	3	16652169 (1), 18639344 (1)
hypersensitivity contact	36.38	1	19358983 (1)
inflammation	34.23	11	16275384 (4), 18451325 (1), 15912097 (1), 18324481 (1) (see all 6)
biliary cirrhosis primary	27.40	1	16126962 (1)
colitis	27.34	2	19117830 (1)
leukemia t-cell	22.16	3	18510697 (2), 15466453 (1)
lymphopenia	21.66	1	17484867 (1)

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GeneTests: FOXP3

IPEX Syndrome

Human Gene Mutation Database: FOXP3
Genetic Association Database: FOXP3
Human Genome Epidemiology Navigator: FOXP3 (19 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/347 PubMed articles for FOXP3 gene (see all 347 ):

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. (PubMed id 11138001)^{2, 3, 4} Brunkow M.E....Ramsdell F. (2001)
No association between variation of the FOXP3 gene and common type 1 diabetes in the Sardinian population. (PubMed id 15220219)^{1, 3, 6} Zavattari P....Cucca F. (2004)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{3, 4} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
A functional polymorphism in the promoter/enhancer region of the FOXP3/Scurfin gene associated with type 1 diabetes. (PubMed id 12750858)^{3, 6} Bassuny W.M....Hara T. (2003)
X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. (PubMed id 11137992)^{3, 4} Wildin R.S....Brunkow M.E. (2001)
Novel mutations of FOXP3 in two Japanese patients with immune dysregulation, polyendocrinopathy, enteropathy, X linked syndrome (IPEX). (PubMed id 11768393)^{3, 4} Kobayashi I....Kobayashi K. (2001)
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. (PubMed id 11137993)^{3, 4} Bennett C.L.... Ochs H.D. (2001)
X-Linked syndrome of polyendocrinopathy, immune dysfunction, and diarrhea maps to Xp11.23-Xq13.3. (PubMed id 10677306)^{2, 3} Bennett C.L....Chance P.F. (2000)
JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. (PubMed id 11120765)^{3, 4} Chatila T.A.... Bowcock A.M. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 50943	HGNC: 6106	AceView: FOXP3	Ensembl:ENSG00000049768	euGenes: HUgn50943
ECgene: FOXP3	H-InvDB: FOXP3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for FOXP3	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=FOXP3

Licensable Technologies for FOXP3
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FOXP3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FOXP3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FOXP3		Antibodies for FOXP3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for FOXP3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (FOXP3)
	Antibodies (FOXP3)
	Chimera RNAi (FOXP3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (FOXP3, FOXP3 (exon 2 deleted))
	Antibodies (FOXP3, FOXP3 (exon 2 deleted))

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for FOXP3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

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FOXP3 Gene at Home site.
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FOXP3 Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for FOXP3

Summaries
for FOXP3

Genomic Location
for FOXP3

Proteins
for FOXP3

Protein Domains/
Families
for FOXP3

Gene Function
for FOXP3

Pathways & Interactions
for FOXP3

Drugs & Compounds
for FOXP3

Transcripts
for FOXP3

Expression
for FOXP3

Orthologs
for FOXP3

Paralogs
for FOXP3

SNPs/Variants
for FOXP3

Disorders & Mutations
for FOXP3

Medical News
for FOXP3

Publications
for FOXP3

Search for FOXP3

Genome Databases showing FOXP3

Other Databases showing FOXP3

Specialized Databases showing FOXP3

Licensable Technologies
for FOXP3

Services
for FOXP3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FOXP3 Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor FOXP3

Summariesfor FOXP3

Genomic Locationfor FOXP3

Proteinsfor FOXP3

Protein Domains/Familiesfor FOXP3

Gene Functionfor FOXP3

Pathways & Interactionsfor FOXP3

Drugs & Compoundsfor FOXP3

Transcriptsfor FOXP3

Expression for FOXP3

Orthologsfor FOXP3

Paralogsfor FOXP3

SNPs/Variantsfor FOXP3

Disorders & Mutationsfor FOXP3

Medical Newsfor FOXP3

Publicationsfor FOXP3

Search for FOXP3

Genome Databases showing FOXP3

Other Databases showing FOXP3

Specialized Databases showing FOXP3

Licensable Technologiesfor FOXP3

Servicesfor FOXP3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FOXP3

Summaries
for FOXP3

Genomic Location
for FOXP3

Proteins
for FOXP3

Protein Domains/
Families
for FOXP3

Gene Function
for FOXP3

Pathways & Interactions
for FOXP3

Drugs & Compounds
for FOXP3

Transcripts
for FOXP3

Expression
for FOXP3

Orthologs
for FOXP3

Paralogs
for FOXP3

SNPs/Variants
for FOXP3

Disorders & Mutations
for FOXP3

Medical News
for FOXP3

Publications
for FOXP3

Licensable Technologies
for FOXP3

Services
for FOXP3