FOXP3 Gene
protein-coding GIFtS: 64
GCID: GC0XM049106
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|
forkhead box P3(Previous names: immune dysregulation, polyendocrinopathy, enteropathy,...)
(Previous symbol: IPEX)
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Aliases
for FOXP3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Forkhead Box P31 2 | | JM21 | | IPEX1 2 3 5 | | SCURFIN1 | | AIID1 2 5 | | FOXP3delta72 | | PIDX1 2 5 | | Forkhead Box Protein P32 | | XPID1 2 5 | | Immunodeficiency, Polyendocrinopathy, Enteropathy, X-Linked2 | | DIETER1 2 | | Scurfin3 | | Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked1 2 | | Scurfin3 |
Export aliases for FOXP3 gene to outside databasesPrevious GC identifers: GC0XM047890 GC0XM047348 GC0XM047913 GC0XM048133 GC0XM048863 GC0XM048993 GC0XM046763 |
Summaries
for FOXP3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FOXP3:
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defectsin this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also knownas X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding differentisoforms have been identified. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: FOXP3_HUMAN, Q9BZS1Function: Probable transcription factor. Plays a critical role in the control of immune response
Gene Wiki entry for FOXP3
|
Genomic Views
for FOXP3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_079573.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FOXP3 gene promoter:
CREB AML1a deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for FOXP3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXP3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23FOXP3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM049106: view genomic region
(about GC identifiers)
Start:
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49,106,897 bp from pter |
End:
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49,121,288 bp from pter |
Size:
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14,392 bases |
Orientation:
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minus strand |
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Proteins
for FOXP3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FOXP3_HUMAN, Q9BZS1 (See
protein sequence)Recommended Name: Forkhead box protein P3 Size: 431 amino acids; 47244 Da
Subunit: Interacts with IKZF3
Subcellular location: Nucleus (Potential)
1 PDB 3D structure from  and Proteopedia  for FOXP3:3QRF (3D)
Secondary accessions: A5HJT1 B7ZLG0 O60827 Q14DD8 Q4ZH51Alternative splicing: 3 isoforms: Q9BZS1-1 Q9BZS1-2 Q9BZS1-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FOXP3: NX_Q9BZS1
Post-translational modifications:
Acetylation on lysine residues stabilizes FOXP3 and promotes differentiation of T-cells into induced regulatory T-cells(iTregs) associated with suppressive functions. Deacetylated by SIRT11
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BZS1
FOXP3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001107849.1 NP_054728.2
ENSEMBL proteins: ENSP00000365380 ENSP00000451208 ENSP00000428952 ENSP00000365369 ENSP00000365372 ENSP00000396415
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
FOXP3 for ontologies About GeneDecksing
FOXP3 Antibody Products:
Assay Products for FOXP3: |
Protein
Domains /
Families
for FOXP3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FOXP3 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9BZS1ProtoNet protein and cluster: Q9BZS1 UniProtKB/Swiss-Prot: FOXP3_HUMAN, Q9BZS1Similarity: Contains 1 C2H2-type zinc fingerSimilarity: Contains 1 fork-head DNA-binding domain |
Function
for FOXP3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FOXP3_HUMAN, Q9BZS1Function: Probable transcription factor. Plays a critical role in the control of immune response
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXP3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXP3 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): FOXP3 (NM_014009) | |  | Sino Biological Human cDNA Clone for FOXP3 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOXP3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXP3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXP3 |
Gene Ontology (GO): 5/15 molecular function terms (GO ID links to tree view) (see all 15): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003682 | chromatin binding |
IBA | -- | | GO:0003690 | double-stranded DNA binding |
IBA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
NAS | 11138001 | | GO:0003705 | RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity |
IBA | -- | | GO:0003714 | transcription corepressor activity |
IBA | -- |
FOXP3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for FOXP3:
Animal Models:
Mouse knock-outs for FOXP3: Foxp3tm1Tch Foxp3tm1.1Ayr
15/21 MGI mutant phenotypes (inferred from 26 alleles ) (MGI details for Foxp3) (see all 21):
FOXP3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for FOXP3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Wnt / Hedgehog / Notch | | | 2 | Lymphocyte Signaling | | | 3 | Calcium signaling in the CD4+ TCR pathway | | | 4 | Mucin expression in CF via IL-6, IL-17 signaling pathways | | | 5 | IL2 signaling events mediated by PI3K | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  R&D Systems Pathway for FOXP3
2 
Cell Signaling Technology (CST) Pathways for FOXP3
1  GeneGo (Thomson Reuters) Pathway for FOXP3
2  BioSystems Pathways for FOXP3
FOXP3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FOXP3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 23)
5/29 Interacting proteins for FOXP3 (Q9BZS11, 3 ENSP000003653804) via UniProtKB, MINT, STRING, and/or I2D (see all 29)About this table
Gene Ontology (GO): 5/72 biological process terms (GO ID links to tree view) (see all 72): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
-- | -- | | GO:0001782 | B cell homeostasis |
IBA | -- | | GO:0001816 | cytokine production |
IEA | -- | | GO:0002053 | NOT positive regulation of mesenchymal cell proliferation |
IRD | -- | | GO:0002262 | myeloid cell homeostasis |
IBA | -- |
FOXP3 for ontologies About GeneDecksing
|
Drugs & Compounds
for FOXP3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
FOXP3 for compounds About GeneDecksing
 Browse Tocris compounds for FOXP3
6 Novoseek chemical compound relationships for FOXP3 gene About this table
Search CenterWatch for drugs/clinical trials and news about FOXP3
|
Transcripts
for FOXP3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FOXP3 gene (2 alternative transcripts): NM_001114377.1 NM_014009.3 Unigene Cluster for FOXP3: Forkhead box P3 Hs.247700 [show with all ESTs]Unigene Representative Sequence: NM_0140096 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000376207(uc011mnb.2 uc011mnc.2 uc004dnf.4 uc004dne.4)
ENST00000557224 ENST00000518685 ENST00000376197(uc022bwa.1) ENST00000376199
ENST00000455775
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXP3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXP3 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FOXP3 (NM_014009) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOXP3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXP3 |
Additional cDNA sequence: AF277993.1 AK292052.1 AK299988.1 BC113401.1 BC113403.1 BC143785.1 BC143786.1 DQ010327.1 EF534714.1 EU855812.1 3 DOTS entries: DT.95248575 DT.121322321 DT.100736036 6 AceView cDNA sequences: AJ005891 NM_014009 BM832990 AF277993 BM918693 BP338852
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for FOXP3 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FOXP3
|
Expression
for FOXP3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FOXP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTGCCTTCT
About this image
See FOXP3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FOXP3
SOURCE GeneReport for Unigene cluster: Hs.247700
SABiosciences Expression via Pathway-Focused PCR Arrays including FOXP3 (see all 9):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOXP3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FOXP3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXP3 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXP3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXP3 |
Orthologs
for FOXP3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FOXP3 gene from 5/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FOXP36FOXP46 |
Uncharacterized protein |
2(a)14(a) |
possible ortholog1 ↔ 1 |
1(78726042-78727833) 26(4670411-4694004) |
lizard
(Anolis carolinensis) |
Reptilia |
FOXP36 |
-- |
64(a) |
1 ↔ 1 |
2(89108082-89110227) |
zebrafish
(Danio rerio) |
Actinopterygii |
foxp3b6foxp3a6 |
forkhead box P3a |
28(a)20(a) |
possible ortholog1 ↔ 1 |
8(24289354-24306939) 8(26569253-26582486) |
fruit fly
(Drosophila melanogaster) |
Insecta |
FoxP6 |
Forkhead box P |
19(a) |
1 ↔ 1 |
3R(5551742-5555165) |
worm
(Caenorhabditis elegans) |
Secernentea |
fkh-96 |
ForKHead transcription factor family member (fkh-9... |
12(a) |
possible ortholog |
X(3817407-3826944) |
ENSEMBL Gene Tree for FOXP3 (if available)
TreeFam Gene Tree for FOXP3 (if available) |
Paralogs
for FOXP3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FOXP3 gene
- FOXJ12 FOXN32 FOXK12 FOXN42 FOXN12 FOXK22 FOXP42 FOXG12
- FOXJ32 FOXJ22 FOXP22 FOXN22 FOXP12
5 SIMAP similar genes for FOXP3 using alignment to 3 protein entries: FOXP3_HUMAN (see all proteins):DKFZp762O213 hFKHLB FOXP4 FOXP2 FOXP1
FOXP3 for paralogs About GeneDecksing
|
Genomic Variants
for FOXP3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FOXP3 (49106897 - 49121288 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for FOXP3
4 CNVs: 0824 73973 2278 7789
Human Gene Mutation Database (HGMD): FOXP3
Locus Specific Mutation Databases (LSDB): FOXP3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOXP3 |
|
Disorders
/ Diseases
for FOXP3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FOXP3 for disorders About GeneDecksing
OMIM gene information: 300292
OMIM disorders: 304790 222100
UniProtKB/Swiss-Prot: FOXP3_HUMAN, Q9BZS1
Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX)[MIM:304790]; also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onsetinsulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usuallylethal in infancy
20/127  diseases for FOXP3 (see all 127): About MalaCardsimmunodysregulation, polyendocrinopathy and enteropathy x-linked immune dysregulation, polyendocrinopathy, enteropathy, x-linked syndrome immunodeficiency relapsing-remitting multiple sclerosis
diffuse large b-cell lymphoma human t-cell leukemia virus type 1 hypersensitivity reaction type ii disease immunodysregulation
graft versus host disease b-cell lymphomas diabetes mellitus secretory diarrhea
gastroesophageal reflux disease systemic lupus erythematosus inverted papilloma non-hodgkin lymphoma
food allergy type 1 diabetes mellitus major depressive disorder autoimmune enteropathy
13 diseases from the University of Copenhagen DISEASES database for FOXP3:Hypersensitivity reaction type II disease Hypersensitivity reaction type I disease Multiple sclerosis Asthma
Diabetes mellitus Arthritis Inflammatory bowel disease Melanoma
Connective tissue disease Dermatitis Lymphoma Allergic rhinitis
Lymphopenia 10/28 Novoseek disease relationships for FOXP3 gene (see all 28) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| autoimmune diseases |
70.1 |
18 |
16920951 (1), 19568423 (1), 16216670 (1), 16741580 (1) (see all 15) |
| polyendocrinopathies autoimmune |
69.6 |
5 |
19122524 (2), 16682278 (1), 15703687 (1) |
| autoimmunity |
67 |
14 |
16682278 (1), 16741580 (1), 18317533 (1), 20309000 (1) (see all 11) |
| colitis |
39.4 |
4 |
19471859 (1), 19117830 (1) |
| inflammation |
38.3 |
13 |
16275384 (4), 18451325 (1), 15912097 (1), 19953886 (1) (see all 8) |
| paraparesis tropical spastic |
33.1 |
3 |
16652169 (1), 18639344 (1) |
| hypersensitivity contact |
30.8 |
1 |
19358983 (1) |
| eczema |
28 |
3 |
19471859 (1), 17217101 (1), 18951619 (1) |
| leukemia t-cell |
25.6 |
3 |
18510697 (2), 15466453 (1) |
| lymphopenia |
24.5 |
1 |
17484867 (1) |
GeneTests: FOXP3
IPEX Syndrome
Genetic Association Database (GAD): FOXP3
Human Genome Epidemiology (HuGE) Navigator: FOXP3 (36 documents)
Export disorders for FOXP3 gene to outside databases
|
Publications
for FOXP3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FOXP3 gene, integrated from 9 sources (see all 660):
(articles sorted by number of sources associating them with FOXP3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. (PubMed id 11138001)1, 2, 3 Brunkow M.E.... Ramsdell F. (2001)
- No association between variation of the FOXP3 gene and common type 1 diabetes in the Sardinian population. (PubMed id 15220219)1, 4, 9 Zavattari P....Cucca F. (2004)
- Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells. (PubMed id 22312127)1, 2 Kwon H.S.... Ott M. (2012)
- Activation of the aryl hydrocarbon receptor induces h uman type 1 regulatory T cell-like and Foxp3(+) regulatory T cells. (PubMed id 20676092)1, 2 Gandhi R....Quintana F.J. (2010)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A functional polymorphism in the promoter/enhancer region of the FOXP3/Scurfin gene associated with type 1 diabetes. (PubMed id 12750858)1, 4 Bassuny W.M....Hara T. (2003)
- X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. (PubMed id 11137992)1, 2 Wildin R.S....Brunkow M.E. (2001)
- Novel mutations of FOXP3 in two Japanese patients with immune dysregulation, polyendocrinopathy, enteropathy, X linked syndrome (IPEX). (PubMed id 11768393)1, 2 Kobayashi I....Kobayashi K. (2001)
- The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. (PubMed id 11137993)1, 2 Bennett C.L.... Ochs H.D. (2001)
|
External Searches for FOXP3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FOXP3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FOXP3 gene
(According to HUGE)
About This Section
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Specialized Databases showing FOXP3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for FOXP3 | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for FOXP3 | Genetics and Cytogenetics in Oncology and Haematology | | FOXP3base | http://bioinf.uta.fi/FOXP3base/ | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/FOXP3 | | Wikipedia | http://en.wikipedia.org/wiki/FOXP3 |
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| Patent Information for FOXP3 gene:
Search GeneIP for patents involving FOXP3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for FOXP3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for FOXP3 | | OriGene shRNA RFP for FOXP3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOXP3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOXP3 | | | OriGene Protein Over-expression Lysate for FOXP3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FOXP3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXP3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXP3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FOXP3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FOXP3 | | OriGene Custom Protein Services for FOXP3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FOXP3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOXP3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXP3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXP3 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXP3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXP3 |
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| | Antibodies & Assays for FOXP3 |
| | | | Search Tocris compounds for FOXP3 |
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 | | | FOXP3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXP3 |
|  |  |  | | | | ThermoFisher Antibody for FOXP3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXP3 |
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