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FOXP1 Gene

protein-coding   GIFtS: 65
GCID: GC03M071088

Forkhead Box P1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Forkhead Box P11 2     PAX5/FOXP1 Fusion Protein1
Fork Head-Related Protein Like B1 2     12CC42
Glutamine-Rich Factor 11 2     Forkhead Box Protein P12
QRF12 5     hFKH1B2

External Ids:    HGNC: 38231   Entrez Gene: 270862   Ensembl: ENSG000001148617   OMIM: 6055155   UniProtKB: Q9H3343   

Export aliases for FOXP1 gene to outside databases

Previous GC identifers: GC03P069520 GC03M070584 GC03M070811 GC03M070926


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FOXP1 Gene:
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription
factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both
development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein
binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a
chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in
multiple transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for FOXP1 Gene:
FOXP1 (forkhead box P1) is a protein-coding gene. Diseases associated with FOXP1 include mental retardation with language impairment and autistic features, and speech disorder. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOXP4.

UniProtKB/Swiss-Prot: FOXP1_HUMAN, Q9H334
Function: Transcriptional repressor. It plays an important role in the specification and differentiation of lung
epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential
transcriptional regulator of B-cell development (By similarity)

Gene Wiki entry for FOXP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FOXP1 gene promoter:
         Nkx3-1   Nkx3-1 v1   RelA   NF-kappaB   MEF-2A   COMP1   aMEF-2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOXP1 promoter sequence
   Search Chromatin IP Primers for FOXP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FOXP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.1   Ensembl cytogenetic band:  3p13   HGNC cytogenetic band: 3p14.1

FOXP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXP1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M071088:  view genomic region     (about GC identifiers)

Start:
71,003,844 bp from pter      End:
71,633,140 bp from pter
Size:
629,297 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FOXP1_HUMAN, Q9H334 (See protein sequence)
Recommended Name: Forkhead box protein P1  
Size: 677 amino acids; 75317 Da
Subunit: Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding.
Interacts with CTBP1 (By similarity)
Sequence caution: Sequence=AAF36135.1; Type=Frameshift; Positions=531, 545; Sequence=ABI33105.1; Type=Erroneous
initiation; Sequence=BAB55005.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for FOXP1:
2KIU (3D)    
Secondary accessions: A3QVP8 B3KV70 G5E9V8 Q8NAN6 Q9BSG9 Q9H332 Q9H333 Q9P0R1
Alternative splicing: 7 isoforms:  Q9H334-1   Q9H334-2   Q9H334-3   Q9H334-4   Q9H334-5   Q9H334-6   Q9H334-7   (No experimental confirmation available. May be due to competing acceptor splice site)

Explore the universe of human proteins at neXtProt for FOXP1: NX_Q9H334

Explore proteomics data for FOXP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FOXP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (9 alternative transcripts): 
    NP_001012523.1  NP_001231737.1  NP_001231739.1  NP_001231741.1  NP_001231742.1  NP_001231743.1  NP_001231744.1  NP_001231745.1  
    NP_116071.2  

    ENSEMBL proteins: 
     ENSP00000318902   ENSP00000419393   ENSP00000418225   ENSP00000420736   ENSP00000333560  
     ENSP00000418102   ENSP00000418524   ENSP00000417857   ENSP00000418883   ENSP00000417941  
     ENSP00000418784   ENSP00000318721  

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    Novus Biologicals FOXP1 Protein
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for FOXP1

    FOXP1 Antibody Products:

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    Abcam antibodies for FOXP1
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    ThermoFisher Antibody for FOXP1
    LSBio Antibodies in human, mouse, rat for FOXP1

    FOXP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FOXP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FOXP1
    Cloud-Clone Corp. CLIAs for FOXP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FOX: Forkhead boxes

    4 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR015880 Znf_C2H2-like
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry Q9H334

    ProtoNet protein and cluster: Q9H334

    UniProtKB/Swiss-Prot: FOXP1_HUMAN, Q9H334
    Domain: The leucine-zipper is required for dimerization and transcriptional repression (By similarity)
    Similarity: Contains 1 C2H2-type zinc finger
    Similarity: Contains 1 fork-head DNA-binding domain


    FOXP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOXP1_HUMAN, Q9H334
    Function: Transcriptional repressor. It plays an important role in the specification and differentiation of lung
    epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential
    transcriptional regulator of B-cell development (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity ----
    GO:0005515protein binding ----
         
    FOXP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FOXP1:
     Small cells 

         11 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Foxp1):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  muscle 
     respiratory system 

    FOXP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FOXP1: Foxp1tm1Rao Foxp1tm1Eem

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FOXP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FOXP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FOXP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FOXP1

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  NYYTGTTTACHN 

    miRNA
    Products:
        
    miRTarBase miRNAs that target FOXP1:
    hsa-mir-1229-3p (MIRT036350), hsa-mir-34a-5p (MIRT005546), hsa-mir-335-5p (MIRT018196), hsa-mir-22-3p (MIRT030641), hsa-mir-33a-5p (MIRT028242), hsa-mir-320a (MIRT044777), hsa-mir-1 (MIRT001054), hsa-mir-122-5p (MIRT003088), hsa-mir-100-5p (MIRT048404)

    Block miRNA regulation of human, mouse, rat FOXP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FOXP1 (see all 175):
    hsa-miR-3938 hsa-miR-199a-3p hsa-miR-605 hsa-miR-519a hsa-miR-3916 hsa-miR-3116 hsa-miR-3649 hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmidFOXP1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FOXP1
    Predesigned siRNA for gene silencing in human, mouse, rat FOXP1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for FOXP1 (see all 12)
    OriGene ORF clones in mouse, rat for FOXP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FOXP1 (NM_032682)
    Sino Biological Human cDNA Clone for FOXP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXP1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for FOXP1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FOXP1_HUMAN, Q9H334: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IBA--

    FOXP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FOXP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    2MicroRNAs in cancer
    MicroRNAs in cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for FOXP1
        Wnt / Hedgehog / Notch



    1 Kegg Pathway  (Kegg details for FOXP1):
        MicroRNAs in cancer


    FOXP1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FOXP1: 
              Stem Cell Transcription Factors in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FOXP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for FOXP1 (Q9H3343 ENSP000003189024) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MTA1Q133303, ENSP000003336334I2D: score=1 STRING: ENSP00000333633
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    FOXP2O154093, ENSP000003862004I2D: score=2 STRING: ENSP00000386200
    GATAD2BQ8WXI93, ENSP000003576444I2D: score=1 STRING: ENSP00000357644
    NCOR2Q9Y6183, ENSP000003485514I2D: score=1 STRING: ENSP00000348551
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development ----
    GO:0002053positive regulation of mesenchymal cell proliferation IBA--
    GO:0002329pre-B cell differentiation IBA--
    GO:0002639positive regulation of immunoglobulin production IBA--
    GO:0006351transcription, DNA-templated IEA--

    FOXP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FOXP1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FOXP1 gene (9 alternative transcripts): 
    NM_001012505.1  NM_001244808.1  NM_001244810.1  NM_001244812.1  NM_001244813.1  NM_001244814.1  NM_001244815.1  NM_001244816.1  
    NM_032682.5  

    Unigene Cluster for FOXP1:

    Forkhead box P1
    Hs.59368  [show with all ESTs]
    Unigene Representative Sequence: BX538242
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000318789(uc003doi.3 uc003dok.3 uc003doj.3 uc003dol.3 uc003dom.3 uc003don.3 uc021xan.1 uc003doo.3 uc003dop.3 uc021xao.1)
    ENST00000475937(uc003doq.1) ENST00000460805 ENST00000497355 ENST00000491238
    ENST00000327590(uc003dor.1) ENST00000498215 ENST00000493089 ENST00000484350
    ENST00000468577 ENST00000485326 ENST00000472382 ENST00000497553 ENST00000318779(uc003dos.3)
    ENST00000470112 ENST00000493010 ENST00000498154 ENST00000471386
    miRNA
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    Block miRNA regulation of human, mouse, rat FOXP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FOXP1 (see all 175):
    hsa-miR-3938 hsa-miR-199a-3p hsa-miR-605 hsa-miR-519a hsa-miR-3916 hsa-miR-3116 hsa-miR-3649 hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmidFOXP1 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 2): FOXP1 (NM_032682)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXP1
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat FOXP1
      QuantiFast Probe-based Assays in human, mouse, rat FOXP1

    Additional mRNA sequence: 

    AB052767.1 AF146696.1 AF151049.1 AF250920.1 AF275309.1 AK026898.1 AK027264.1 AK074321.1 
    AK074569.1 AK092383.1 AK122710.1 AK297649.1 BC005055.1 BC054505.1 BC054815.1 BC068481.1 
    BC071893.1 BC080521.1 BC131720.1 BT006643.1 BX538242.1 CR457164.1 

    Selected DOTS entries (see all 34):

    DT.95260469  DT.120872721  DT.100643840  DT.91853002  DT.95089295  DT.100791122  DT.401136  DT.100020680 
    DT.120872688  DT.101964356  DT.120872787  DT.100791119  DT.95184070  DT.100838141  DT.406492  DT.97789112 
    DT.95170058  DT.97769034  DT.120872775  DT.91717036  DT.91883257  DT.91963644  DT.120872515  DT.120872624 

    Selected AceView cDNA sequences (see all 326):

    AA490197 AA290613 AA878217 CD557168 AW072758 BC054815 BG431328 BF196128 
    AL598282 AW027369 Z40334 AA620867 AI471479 AA286954 BM718511 AW504170 
    CA429491 AW193243 BM824115 BC071893 AA743131 BQ017021 AI144309 AI475788 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FOXP1 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                  -     -                                                   
    SP3:                                                                                                                                                            
    SP4:        -     -                                                                                                                                             
    SP5:                                                                                                                                                            

    ExUns: 25a · 25b ^ 26a · 26b ^ 27
    SP1:        -     -               
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for FOXP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FOXP1 expression in normal human tissues (normalized intensities)      FOXP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTGACTAT
    FOXP1 Expression
    About this image


    FOXP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Neurons
             Lateral Motor Neurons Lumbar Lateral Motor Column
             Lateral motor column neuron-like cells
     
     Spinal Cord (Nervous System)    fully expand to see all 7 entries
             Lateral Motor Neurons Lumbar Lateral Motor Column
             Lateral motor column neuron-like cells
     
     Motor Neurons (Nervous System)
             Lateral motor column neuron-like cells
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone Marrow
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
    FOXP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FOXP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.59368
        Pathway & Disease-focused RT2 Profiler PCR Arrays including FOXP1: 
              Stem Cell Transcription Factors in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FOXP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FOXP1
    QuantiTect SYBR Green Assays in human, mouse, rat FOXP1
    QuantiFast Probe-based Assays in human, mouse, rat FOXP1
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FOXP1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Foxp15 forkhead box P1   --   6 (45.74 cM) 98925338 
    chicken
    (Gallus gallus)
    Aves FOXP16
    Gallus gallus forkhead box P1 (FOXP1), mRNA.
    87(a)
    1 ↔ 1
    12(15895826-16091944)
    lizard
    (Anolis carolinensis)
    Reptilia FOXP16
    forkhead box P1
    85(a)
    1 ↔ 1
    2(180451398-180916984)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.330692 Xenopus laevis transcribed sequence with moderate similarity more 83.01(n)    BX843186.1 
    zebrafish
    (Danio rerio)
    Actinopterygii foxp1b6
    forkhead box P1b
    75(a)
    1 ↔ 1
    6(43529979-43821762) ENSDARG00000014181
    fruit fly
    (Drosophila melanogaster)
    Insecta CG168993 transcription factor 78(a)   85E5   --
    worm
    (Caenorhabditis elegans)
    Secernentea fkh-86
    fkh-76
    Protein FKH-8, isoform a (fkh-8) mRNA, complete cd...
    Protein FKH-7, isoform a (fkh-7) mRNA, complete cd...
    25(a)
    24(a)
    many ↔ many
    many ↔ many
    II(6189580-6191402) WBGene00001440
    IV(5584661-5610364) WBGene00001439


    ENSEMBL Gene Tree for FOXP1 (if available)
    TreeFam Gene Tree for FOXP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FOXP1 gene
    FOXP42  FOXP22  FOXP32  
    8 SIMAP similar genes for FOXP1 using alignment to 10 protein entries:     FOXP1_HUMAN (see all proteins):
    hFKHLB    FOXP4    DKFZp762O213    FOXP2    DKFZp686H1726    FOXN4
    FOXJ3    FOXP3

    FOXP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FOXP1 (see all 12340)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1127953011,2
    Cpathogenic170974284(+) TACTCG/ACACAA 15 /R /* stg1 int11Minor allele frequency- A:0.50NA 2
    rs1422252121,2
    --70955905(+) TCTAAG/TCATTT 8 -- ds50010--------
    rs1911953151,2
    --70955971(+) TGACAG/TTAGCA 8 -- ds50010--------
    rs1445292901,2
    --70956170(+) TTTTAC/TTTCCC 8 -- ds50010--------
    rs1477695031,2
    --70956246(+) TGAAAG/TCTTTA 8 -- ds50010--------
    rs1401437671,2
    --70956255(+) TAAGAC/TTGATT 8 -- ds50010--------
    rs1840436471,2
    --70956353(+) AGGCTA/GTGGCA 8 -- ds50010--------
    rs1503185351,2
    --70956359(+) TGGCAA/GCTTTT 8 -- ds50010--------
    rs1891121331,2
    --70956385(+) AACCAA/GCATTT 8 -- ut310--------
    rs1930428251,2
    --70956489(+) AATTAC/TAGTTG 8 -- ut310--------

    HapMap Linkage Disequilibrium report for FOXP1 (71003844 - 71253844 bp, first 250kb of FOXP1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FOXP1 (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2669957CNV Deletion23128226
    esv2677522CNV Deletion23128226
    esv2534232CNV Deletion19546169
    esv2725400CNV Deletion23290073
    esv267511CNV Insertion20981092
    esv269572CNV Insertion20981092
    esv995297CNV Insertion20482838
    nsv508932CNV Insertion20534489
    esv272787CNV Insertion20981092
    esv1199783CNV Insertion17803354

    Human Gene Mutation Database (HGMD): FOXP1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FOXP1
    DNA2.0 Custom Variant and Variant Library Synthesis for FOXP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605515   
    OMIM disorders: 613670  
    UniProtKB/Swiss-Prot: FOXP1_HUMAN, Q9H334
  • Note=A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. Translocation
    t(9;3)(p13;p14.1) with PAX5
  • Mental retardation with language impairment and autistic features (MRLIAF) [MIM:613670]: A developmental
    disorder characterized by mild to moderate mental retardation, language impairment, and autistic features.
    Patients show global delay, delayed walking, severely delayed speech development, and behavioral abnormalities,
    including irritability, hyperactivity, aggression, and stereotypical rigid behaviors. Note=The disease is caused
    by mutations affecting the gene represented in this entry

  • Selected diseases for FOXP1 (see all 42):    About MalaCards
    mental retardation with language impairment and autistic features    speech disorder    malt lymphoma    hypertonia
    precursor b-cell acute lymphoblastic leukemia    thyroid lymphoma    blepharophimosis    splenic marginal zone lymphoma
    central nervous system lymphoma    diffuse large b-cell lymphoma    peripheral t-cell lymphoma    familial breast cancer
    follicular lymphoma    attention deficit hyperactivity disorder    b-cell lymphomas    vitiligo
    clear cell renal cell carcinoma    intellectual disability    mental retardation    endometriosis

    2 diseases from the University of Copenhagen DISEASES database for FOXP1:
    Lymphoma     Speech disorder

    FOXP1 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for FOXP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma b-cell 72.1 9 15944719 (2), 18077790 (2), 16252263 (2), 15709173 (1) (see all 5)
    speech disorders 69.2 2 15056695 (1)
    tumors 0 10 11751404 (7), 15944719 (1)
    cancer 0 4 11751404 (2), 15709173 (1)

    Genetic Association Database (GAD): FOXP1
    Human Genome Epidemiology (HuGE) Navigator: FOXP1 (8 documents)

    Export disorders for FOXP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FOXP1 gene, integrated from 10 sources (see all 107):
    (articles sorted by number of sources associating them with FOXP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p. (PubMed id 11751404)1, 2, 3, 9 Banham A.H....Cordell J.L. (Cancer Res. 2001)
    2. Assessing the impact of FOXP1 mutations on developmental verbal dyspraxia. (PubMed id 19352412)1, 2, 4 Vernes S.C.... Fisher S.E. (Eur. J. Hum. Genet. 2009)
    3. Identification of FOXP1 deletions in three unrelated patients with mental retardation and significant speech and language deficits. (PubMed id 20848658)1, 2 Horn D.... Strom T.M. (Hum. Mutat. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. De novo mutations in FOXP1 in cases with intellectual disability, autism, and language impairment. (PubMed id 20950788)1, 2 Hamdan F.F....Michaud J.L. (Am. J. Hum. Genet. 2010)
    6. Common variants in FOXP1 are associated with generalized vitiligo. (PubMed id 20526340)1, 4 Jin Y....Spritz R.A. (Nat. Genet. 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. (PubMed id 18821565)1, 4 Lasky-Su J....Faraone S.V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    9. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. (PubMed id 17344859)1, 2 Mullighan C.G.... Downing J.R. (Nature 2007)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27086 HGNC: 3823 AceView: FOXP1 Ensembl:ENSG00000114861 euGenes: HUgn27086
    ECgene: FOXP1 Kegg: 27086 H-InvDB: FOXP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FOXP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FOXP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FOXP1 gene:
    Search GeneIP for patents involving FOXP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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