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Aliases for FOXP1 Gene

Aliases for FOXP1 Gene

  • Forkhead Box P1 2 3 5
  • Fork Head-Related Protein Like B 2 3
  • Mac-1-Regulated Forkhead 3 4
  • Glutamine-Rich Factor 1 2 3
  • MFH 3 4
  • PAX5/FOXP1 Fusion Protein 2
  • Forkhead Box Protein P1 3
  • HSPC215 3
  • HFKH1B 3
  • 12CC4 3
  • QRF1 3

External Ids for FOXP1 Gene

Previous GeneCards Identifiers for FOXP1 Gene

  • GC03P069520
  • GC03M070584
  • GC03M070811
  • GC03M071088

Summaries for FOXP1 Gene

Entrez Gene Summary for FOXP1 Gene

  • This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXP1 Gene

FOXP1 (Forkhead Box P1) is a Protein Coding gene. Diseases associated with FOXP1 include Mental Retardation With Language Impairment And With Or Without Autistic Features and Lymphoma, Malt, Somatic. Among its related pathways are Wnt / Hedgehog / Notch and MicroRNAs in cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is FOXP2.

UniProtKB/Swiss-Prot for FOXP1 Gene

  • Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintainance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18799727, PubMed:18347093). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093).

  • Isoform 8: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5-CGATACAA-3 (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity).

Gene Wiki entry for FOXP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXP1 Gene

Genomics for FOXP1 Gene

Regulatory Elements for FOXP1 Gene

Enhancers for FOXP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F071540 1.4 VISTA Ensembl ENCODE 12.6 +41.6 41640 3.1 PKNOX1 CBX3 ATF1 SIN3A RAD21 ZNF121 GATA2 ZNF366 SCRT2 CREM FOXP1 FOXP1-IT1 MIR1284 LOC105377154
GH03F071545 1.2 Ensembl ENCODE 12.6 +36.2 36219 3.9 ELF3 ARID4B RAD21 RARA YY1 GATA4 FOS CREM THAP11 HMG20B FOXP1 FOXP1-IT1 MIR1284 LOC105377154
GH03F071778 1.3 FANTOM5 Ensembl ENCODE 4 -195.8 -195812 2.0 CTCF ZNF639 RNF2 ETV1 TEAD4 MAX CEBPB DPF2 GABPA ARID1B PROK2 GPR27 EIF4E3 FOXP1
GH03F072076 1.6 FANTOM5 Ensembl ENCODE 2.6 -496.4 -496382 7.3 HDGF PKNOX1 ATF1 YBX1 FEZF1 GATA2 FOS JUNB TBX21 PPARG RYBP PROK2 GPR27 EIF4E3 LINC00877 FOXP1 ENSG00000276471 ENSG00000273461
GH03F071784 0.7 FANTOM5 3.9 -200.4 -200399 0.2 RNF2 ZBTB48 CBX2 KDM1A EZH2 PROK2 GPR27 EIF4E3 FOXP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FOXP1 on UCSC Golden Path with GeneCards custom track

Promoters for FOXP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001367151 1889 6601 ARID4B SIN3A FEZF1 DMAP1 FOS ZNF263 SP3 SP5 MXD4 KAT8

Genomic Location for FOXP1 Gene

Chromosome:
3
Start:
70,954,693 bp from pter
End:
71,583,989 bp from pter
Size:
629,297 bases
Orientation:
Minus strand

Genomic View for FOXP1 Gene

Genes around FOXP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXP1 Gene

Proteins for FOXP1 Gene

  • Protein details for FOXP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H334-FOXP1_HUMAN
    Recommended name:
    Forkhead box protein P1
    Protein Accession:
    Q9H334
    Secondary Accessions:
    • A3QVP8
    • B3KV70
    • G5E9V8
    • Q8NAN6
    • Q9BSG9
    • Q9H332
    • Q9H333
    • Q9P0R1

    Protein attributes for FOXP1 Gene

    Size:
    677 amino acids
    Molecular mass:
    75317 Da
    Quaternary structure:
    • Forms homodimers and heterodimers with FOXP2 and FOXP4 (PubMed:25027557). Dimerization is required for DNA-binding. Self-associates (PubMed:26647308). Interacts with CTBP1 (By similarity). Interacts with NCOR2 and AR (PubMed:18347093, PubMed:18640093). Interacts with FOXP2 (PubMed:26647308).
    SequenceCaution:
    • Sequence=AAF36135.1; Type=Frameshift; Positions=531, 545; Evidence={ECO:0000305}; Sequence=ABI33105.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55005.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FOXP1 Gene

    Alternative splice isoforms for FOXP1 Gene

neXtProt entry for FOXP1 Gene

Post-translational modifications for FOXP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FOXP1 Gene

Domains & Families for FOXP1 Gene

Gene Families for FOXP1 Gene

Protein Domains for FOXP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H334

UniProtKB/Swiss-Prot:

FOXP1_HUMAN :
  • The leucine-zipper is required for dimerization and transcriptional repression.
  • Contains 1 C2H2-type zinc finger.
Domain:
  • The leucine-zipper is required for dimerization and transcriptional repression.
  • Contains 1 fork-head DNA-binding domain.
Similarity:
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with FOXP1: view

Function for FOXP1 Gene

Molecular function for FOXP1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintainance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18799727, PubMed:18347093). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093).
UniProtKB/Swiss-Prot Function:
Isoform 8: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5-CGATACAA-3 (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity).
UniProtKB/Swiss-Prot Induction:
By androgen in an isoform-specific manner; expression of isoform 4 is greatly induced.

Gene Ontology (GO) - Molecular Function for FOXP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXP1: view

Phenotypes for FOXP1 Gene

GenomeRNAi human phenotypes for FOXP1:
genes like me logo Genes that share phenotypes with FOXP1: view

Human Phenotype Ontology for FOXP1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for FOXP1 Gene

miRTarBase miRNAs that target FOXP1
Targeted motifs for FOXP1 Gene
HOMER Transcription Factor Regulatory Elements motif FOXP1
  • Consensus sequence: NYYTGTTTACHN Submotif: canonical Cell Type: H9 GEO ID: GSE31006

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models and Transcription Factor Targets for FOXP1 Gene

Localization for FOXP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXP1 Gene

Nucleus. Note=Not found in the nucleolus. {ECO:0000269 PubMed:26647308}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXP1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for FOXP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 25027557
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with FOXP1: view

Pathways & Interactions for FOXP1 Gene

genes like me logo Genes that share pathways with FOXP1: view

Pathways by source for FOXP1 Gene

1 Cell Signaling Technology pathway for FOXP1 Gene
1 KEGG pathway for FOXP1 Gene

SIGNOR curated interactions for FOXP1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for FOXP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0002053 positive regulation of mesenchymal cell proliferation IEA --
GO:0002329 pre-B cell differentiation IEA --
GO:0002639 positive regulation of immunoglobulin production IEA --
GO:0002903 negative regulation of B cell apoptotic process IDA 25267198
genes like me logo Genes that share ontologies with FOXP1: view

Transcripts for FOXP1 Gene

Unigene Clusters for FOXP1 Gene

Forkhead box P1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1:
SP2: - -
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8:

ExUns: 25a · 25b ^ 26a · 26b ^ 27
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for FOXP1 Gene

GeneLoc Exon Structure for
FOXP1
ECgene alternative splicing isoforms for
FOXP1

Expression for FOXP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FOXP1 Gene

Protein differential expression in normal tissues from HIPED for FOXP1 Gene

This gene is overexpressed in Fetal testis (19.8), Lymph node (11.1), CD4 Tcells (9.7), Peripheral blood mononuclear cells (8.3), and CD8 Tcells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FOXP1 Gene



Protein tissue co-expression partners for FOXP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FOXP1 Gene:

FOXP1

SOURCE GeneReport for Unigene cluster for FOXP1 Gene:

Hs.59368

mRNA Expression by UniProt/SwissProt for FOXP1 Gene:

Q9H334-FOXP1_HUMAN
Tissue specificity: Isoform 8 is specifically expressed in embryonic stem cells.
genes like me logo Genes that share expression patterns with FOXP1: view

Primer Products

No data available for mRNA differential expression in normal tissues for FOXP1 Gene

Orthologs for FOXP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXP1 34 35
  • 99.81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FOXP1 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FOXP1 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXP1 35
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FOXP1 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxp1 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOXP1 35
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXP1 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6946 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.33069 34
zebrafish
(Danio rerio)
Actinopterygii foxp1b 35
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG16899 36
  • 78 (a)
FoxP 35
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea fkh-8 35
  • 25 (a)
ManyToMany
fkh-7 35
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
Species where no ortholog for FOXP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FOXP1 Gene

ENSEMBL:
Gene Tree for FOXP1 (if available)
TreeFam:
Gene Tree for FOXP1 (if available)

Paralogs for FOXP1 Gene

genes like me logo Genes that share paralogs with FOXP1: view

Variants for FOXP1 Gene

Sequence variations from dbSNP and Humsavar for FOXP1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs587777855 Mental retardation with language impairment and autistic features (MRLIAF) [MIM:613670], Uncertain significance 70,972,607(+) TGTCC(A/G)TACTG intron-variant, nc-transcript-variant, reference, missense
rs869025202 Mental retardation with language impairment and autistic features (MRLIAF) [MIM:613670], Pathogenic 70,977,678(-) AAGTT(A/G)GACCA nc-transcript-variant, reference, missense
rs869025203 Mental retardation with language impairment and autistic features (MRLIAF) [MIM:613670], Pathogenic 70,972,667(-) CAGTG(C/T)GTCAT intron-variant, nc-transcript-variant, reference, missense
rs112795301 Pathogenic 70,972,634(+) TACTC(A/G)CACAA intron-variant, nc-transcript-variant, reference, stop-gained
rs398124429 Pathogenic 70,970,772(-) AGCAG(-/AAAACATGCAGAGCAG)CCACG nc-transcript-variant, reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for FOXP1 Gene

Variant ID Type Subtype PubMed ID
nsv999942 CNV gain 25217958
nsv954882 CNV deletion 24416366
nsv954881 CNV deletion 24416366
nsv954880 CNV duplication 24416366
nsv834728 CNV loss 17160897
nsv834727 CNV loss 17160897
nsv590599 CNV gain 21841781
nsv590598 CNV gain 21841781
nsv525748 CNV loss 19592680
nsv525539 CNV gain 19592680
nsv524874 CNV loss 19592680
nsv523960 CNV loss 19592680
nsv508932 CNV insertion 20534489
nsv474624 CNV novel sequence insertion 20440878
nsv3872 CNV insertion 18451855
nsv3871 CNV deletion 18451855
nsv237399 CNV insertion 16902084
nsv1145779 CNV deletion 26484159
nsv1144993 CNV deletion 24896259
nsv1127968 CNV deletion 24896259
nsv1121610 CNV deletion 24896259
nsv1118976 CNV deletion 24896259
nsv1074601 CNV deletion 25765185
nsv1073653 CNV deletion 25765185
nsv1010076 CNV gain 25217958
esv995297 CNV insertion 20482838
esv3596525 CNV loss 21293372
esv3596524 CNV loss 21293372
esv3596520 CNV loss 21293372
esv3596519 CNV loss 21293372
esv3568846 CNV loss 25503493
esv3568845 CNV loss 25503493
esv3562051 CNV deletion 23714750
esv3442839 CNV insertion 20981092
esv3427994 CNV insertion 20981092
esv3408215 CNV insertion 20981092
esv3376617 CNV insertion 20981092
esv3361624 CNV insertion 20981092
esv3326574 CNV insertion 20981092
esv3308514 CNV mobile element insertion 20981092
esv3305619 CNV mobile element insertion 20981092
esv3305294 CNV mobile element insertion 20981092
esv3303231 CNV mobile element insertion 20981092
esv2725400 CNV deletion 23290073
esv2677522 CNV deletion 23128226
esv2669957 CNV deletion 23128226
esv2577699 CNV insertion 19546169
esv2534232 CNV deletion 19546169
esv24809 CNV loss 19812545
esv1199783 CNV insertion 17803354
esv1025789 CNV insertion 17803354

Variation tolerance for FOXP1 Gene

Residual Variation Intolerance Score: 5.98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXP1 Gene

Human Gene Mutation Database (HGMD)
FOXP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXP1 Gene

Disorders for FOXP1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for FOXP1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mental retardation with language impairment and with or without autistic features
  • intellectual disability-severe speech delay-mild dysmorphism syndrome
lymphoma, malt, somatic
  • lymphoma, mucosa-associated lymphoid type
mental retardation with language impairment and autistic features
leukemia, acute lymphoblastic 3
  • burkitt lymphoma
b-cell lymphomas
  • b-cell lymphoma
- elite association - COSMIC cancer census association via MalaCards
Search FOXP1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FOXP1_HUMAN
  • Mental retardation with language impairment and autistic features (MRLIAF) [MIM:613670]: A developmental disorder characterized by mild to moderate mental retardation, language impairment, and autistic features. Patients show global delay, delayed walking, severely delayed speech development, and behavioral abnormalities, including irritability, hyperactivity, aggression, and stereotypical rigid behaviors. {ECO:0000269 PubMed:20950788, ECO:0000269 PubMed:26647308}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. Translocation t(9;3)(p13;p14.1) with PAX5.

Relevant External Links for FOXP1

Genetic Association Database (GAD)
FOXP1
Human Genome Epidemiology (HuGE) Navigator
FOXP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXP1
genes like me logo Genes that share disorders with FOXP1: view

No data available for Genatlas for FOXP1 Gene

Publications for FOXP1 Gene

  1. The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p. (PMID: 11751404) Banham A.H. … Cordell J.L. (Cancer Res. 2001) 2 3 4 22 64
  2. Assessing the impact of FOXP1 mutations on developmental verbal dyspraxia. (PMID: 19352412) Vernes S.C. … Fisher S.E. (Eur. J. Hum. Genet. 2009) 3 4 46 64
  3. Transcriptional Regulation by FOXP1, FOXP2, and FOXP4 Dimerization. (PMID: 25027557) Sin C. … Crawford D.A. (J. Mol. Neurosci. 2015) 3 4 64
  4. Identification and functional characterization of de novo FOXP1 variants provides novel insights into the etiology of neurodevelopmental disorder. (PMID: 26647308) Sollis E. … Fisher S.E. (Hum. Mol. Genet. 2015) 3 4 64
  5. FOXP1 directly represses transcription of pro-apoptotic genes and cooperates with NF-kappaB to promote survival of human B-cells. (PMID: 25267198) van Keimpema M. … Spaargaren M. (Blood 2014) 3 4 64

Products for FOXP1 Gene

Sources for FOXP1 Gene

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