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FOXO6 Gene

protein-coding   GIFtS: 39
GCID: GC01P041827

Forkhead Box O6

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Forkhead Box O61 2
Forkhead Box Protein O62

External Ids:    HGNC: 248141   Entrez Gene: 1001320742   Ensembl: ENSG000002040607   OMIM: 6114575   UniProtKB: A8MYZ63   

Export aliases for FOXO6 gene to outside databases

Previous GC identifers: GC01U900892 GC01P041599


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FOXO6 Gene:
FOXO6 (forkhead box O6) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOXM1.

UniProtKB/Swiss-Prot: FOXO6_HUMAN, A8MYZ6
Function: Transcriptional activator (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the FOXO6 gene promoter:
         HOXA9B   HOXA9   Spz1   RP58   Tal-1   Nkx2-5   E47   HOXA5   STAT3   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FOXO6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FOXO6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.2   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p34.2

FOXO6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXO6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P041827:  view genomic region     (about GC identifiers)

Start:
41,827,227 bp from pter      End:
41,856,020 bp from pter
Size:
28,794 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FOXO6_HUMAN, A8MYZ6 (See protein sequence)
Recommended Name: Forkhead box protein O6  
Size: 492 amino acids; 50595 Da

Explore the universe of human proteins at neXtProt for FOXO6: NX_A8MYZ6

Explore proteomics data for FOXO6 at MOPED

Post-translational modifications: 

  • Phosphorylation of Ser-184 is be important in regulating the transacriptional activity (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FOXO6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001278210.1  
    ENSEMBL proteins: 
     ENSP00000361672  

    FOXO6 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for FOXO6

     
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    antibodies-online proteins for FOXO6 

     
    antibodies-online peptides for FOXO6

    FOXO6 Antibody Products:

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    antibodies-online antibodies for FOXO6 (8 products) 

    FOXO6 Assay Products:

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    Cloud-Clone Corp. ELISAs for FOXO6
    Cloud-Clone Corp. CLIAs for FOXO6
    Search eBioscience for ELISAs for FOXO6 
    antibodies-online kits for FOXO6 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FOX: Forkhead boxes

    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry A8MYZ6

    ProtoNet protein and cluster: A8MYZ6

    UniProtKB/Swiss-Prot: FOXO6_HUMAN, A8MYZ6
    Similarity: Contains 1 fork-head DNA-binding domain


    Find genes that share domains with FOXO6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOXO6_HUMAN, A8MYZ6
    Function: Transcriptional activator (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI--
    GO:0008301DNA binding, bending ----
    GO:0019901protein kinase binding ----
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with FOXO6           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Foxo6):
     behavior/neurological  nervous system 

    Find genes that share phenotypes with FOXO6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Foxo6tm1Abru for FOXO6

       genOway: Develop your customized and physiologically relevant rodent model for FOXO6

    miRNA
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    Block miRNA regulation of human, mouse, rat FOXO6 using miScript Target Protectors
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    Predesigned siRNA for gene silencing in human, mouse, rat FOXO6

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for FOXO6
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    GenScript: all cDNA clones in your preferred vector: FOXO6 (XM_002342102)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXO6
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FOXO6
    Addgene plasmids for FOXO6 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for FOXO6 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXO6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FOXO6_HUMAN, A8MYZ6: Cytoplasm (By similarity). Nucleus (By similarity). Note=When phosphorylated, translocated
    from nucleus to cytoplasm. High nuclear localization after stimulation with growth factors (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005829cytosol ----

    Find genes that share ontologies with FOXO6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FOXO6 About    
    See pathways by source

    SuperPathContained pathways About
    1FoxO signaling pathway
    FoxO signaling pathway


    Find genes that share SuperPaths with FOXO6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for FOXO6):
        FoxO signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FOXO6
    Interactions:

        Search GeneGlobe Interaction Network for FOXO6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for FOXO6 (A8MYZ61, 2 ENSP000003616724) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HNF4AP412351, 2EBI-8531039,EBI-1049011 MINT-8430144 MINT-8429213
    EIF4EBP2ENSP000003623144STRING: ENSP00000362314
    CDKN1AENSP000002447414STRING: ENSP00000244741
    CEBPDENSP000003861654STRING: ENSP00000386165
    RC3H1ENSP000002583494STRING: ENSP00000258349
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006974cellular response to DNA damage stimulus ----
    GO:0007389pattern specification process ----
    GO:0008286insulin receptor signaling pathway ----

    Find genes that share ontologies with FOXO6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FOXO6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FOXO6 gene: 
    NM_001291281.1  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000372591
    miRNA
    Products:
         
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    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat FOXO6
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    OriGene ORF clones in mouse, rat for FOXO6
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    GenScript: all cDNA clones in your preferred vector: FOXO6 (XM_002342102)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXO6
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FOXO6
    Addgene plasmids for FOXO6 
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FOXO6
      Search QuantiTect SYBR Green Assays in human, mouse, rat FOXO6
      QuantiFast Probe-based Assays in human, mouse, rat FOXO6

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FOXO6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FOXO6 Expression
    About this image


    FOXO6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Smooth Muscle (Muscoskeletal System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Endothelium (Cardiovascular System)
             Mature Endothelial Cells Blood Brain Barrier
     
     Kidney (Urinary System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus
    FOXO6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FOXO6 Protein Expression
        Custom PCR Arrays for FOXO6
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXO6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FOXO6 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Foxo61 , 5 forkhead box O61, 5 91.65(n)1
    95.96(a)1
      4 (56.10 cM)5
    3299341  NM_194060.11  NP_918949.11 
     1202670795 
    chicken
    (Gallus gallus)
    Aves LOC1008577671 forkhead box protein O3-like 73.85(n)
    69.52(a)
      100857767  XM_004947712.1  XP_004947769.1 
    lizard
    (Anolis carolinensis)
    Reptilia FOXO66
    forkhead box O6
    30(a)
    1 ↔ 1
    GL343563.1(341026-342582)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia foxo61 forkhead box O6 65.4(n)
    73.65(a)
      100490156  XM_002939355.2  XP_002939401.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-206a7.21 si:ch211-206a7.2 62.94(n)
    61.8(a)
      566899  NM_001135132.1  NP_001128604.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta foxo6
    forkhead box, sub-group O
    23(a)
    1 → many
    3R(9882690-9913700)
    worm
    (Caenorhabditis elegans)
    Secernentea daf-166
    Protein DAF-16, isoform h
    21(a)
    1 → many
    I(10750343-10776700) WBGene00000912
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HCM16
    Forkhead transcription factor that drives S-phase ...
    12(a)
    1 → many
    III(229310-231004) YCR065W


    ENSEMBL Gene Tree for FOXO6 (if available)
    TreeFam Gene Tree for FOXO6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FOXO6 gene
    FOXM12  FOXO42  FOXO32  FOXO12  
    2 SIMAP similar genes for FOXO6 using alignment to 2 protein entries:     FOXO6_HUMAN (see all proteins):
    FOXO4    FKHRL1P2

    Find genes that share paralogs with FOXO6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FOXO6 (see all 503)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1868346251,2
    --39944075(+) GGTGGC/GGGTGG 2 R G mis10--------
    rs1807899131,2
    --39948946(+) CCCTCA/GCTCCC 1 -- int10--------
    rs717156351,2
    C--41828124(+) GGCAC-/CCCCCC 1 -- int10--------
    rs355104741,2
    C--41833312(+) TTTTT-/TCTGAG 1 -- int12Minor allele frequency- T:0.25NA 4
    rs559245161,2
    C--41841149(+) AAAGA-/AAGAAAG
    AAAGAAAGA
    GGAAA
    1 -- int11Minor allele frequency- AAGAAAGAAAGAAAGA:0.00NA 2
    rs562025161,2
    C--41846597(+) GGGGAC/-CCCCA 1 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs120928251,2
    C--41848060(+) caccgC/Tcgggc 2 P S mis1 ese30--------
    rs1141780431,2
    C,F--41895907(+) ACAAGC/ATGACT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1830438501,2
    C--41895921(+) AAAGGC/TGTTGG 1 -- us2k10--------
    rs798810191,2
    C,F--41896256(+) GGGGAC/TGGAGG 1 -- us2k11Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for FOXO6 (41827227 - 41856020 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FOXO6: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing FOXO6
    DNA2.0 Custom Variant and Variant Library Synthesis for FOXO6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611457    OMIM disorders: --


    Find genes that share disorders with FOXO6           About GenesLikeMe

    Genetic Association Database (GAD): FOXO6
    Human Genome Epidemiology (HuGE) Navigator: FOXO6 (1 document)

    Export disorders for FOXO6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FOXO6 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FOXO6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1, 4 (Nat. Genet. 2011)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics. (PubMed id 12857750)1, 3 Jacobs F.M....Smidt M.P. (J. Biol. Chem. 2003)
    4. FoxO6 in glucose metabolism (FoxO6). (PubMed id 23324123)1 Kim D.H....Dong H.H. (J Diabetes 2013)
    5. FOXO6 promotes gastric cancer cell tumorigenicity via upregulation of C-myc. (PubMed id 23714368)1 Qinyu L....Cheng-hong P. (FEBS Lett. 2013)
    6. Candidate gene study of FOXO1, FOXO4, and FOXO6 reveals no association with human longevity in Germans. (PubMed id 21388494)1 Kleindorp R....Nebel A. (Aging Cell 2011)
    7. FoxO6 integrates insulin signaling with gluconeogenesis in the liver. (PubMed id 21940782)1 Kim D.H....Dong H.H. (Diabetes 2011)
    8. FoxO transcription factors; Regulation by AKT and 14-3-3 proteins. (PubMed id 21708191)1 Tzivion G....Ramakrishnan G. (Biochim. Biophys. Acta 2011)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 100132074 HGNC: 24814 Ensembl:ENSG00000204060 euGenes: HUgn100132074 ECgene: FOXO6 Kegg: 100132074
    H-InvDB: FOXO6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FOXO6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FOXO6 gene:
    Search GeneIP for patents involving FOXO6

    GeneCards and IP:
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