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Aliases for FOXO6 Gene

Aliases for FOXO6 Gene

  • Forkhead Box O6 2 3 5

External Ids for FOXO6 Gene

Previous GeneCards Identifiers for FOXO6 Gene

  • GC01U900892
  • GC01P041599
  • GC01P041827

Summaries for FOXO6 Gene

GeneCards Summary for FOXO6 Gene

FOXO6 (Forkhead Box O6) is a Protein Coding gene. Among its related pathways are FoxO signaling pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is FOXO3.

UniProtKB/Swiss-Prot for FOXO6 Gene

  • Transcriptional activator.

Additional gene information for FOXO6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXO6 Gene

Genomics for FOXO6 Gene

Regulatory Elements for FOXO6 Gene

Enhancers for FOXO6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H041380 1.5 Ensembl ENCODE dbSUPER 29.7 +20.3 20313 4 PKNOX1 ZFP64 ZNF133 SIN3A FEZF1 BRCA1 GLIS2 SP3 TSHZ1 SMARCB1 FOXO6 NFYC-AS1 LOC105378672 EXO5 LOC101929901 LOC105378678
GH01H041364 1.7 FANTOM5 Ensembl ENCODE dbSUPER 22.1 +5.4 5432 5.2 PKNOX1 KLF1 BACH1 ZNF223 KLF17 EBF1 ZIC2 HIC1 ZFHX2 PATZ1 FOXO6 ENSG00000235358 SCMH1 PIR34819 GC01P041369
GH01H041386 1.1 ENCODE dbSUPER 22.8 +25.5 25472 2.5 NFIB KLF17 GLIS2 ZNF366 EGR2 ZNF680 USF2 ZNF398 ZFP69B IKZF1 FOXO6 ZFP69 EDN2 LOC101929901 LOC105378678
GH01H041370 1.1 ENCODE dbSUPER 22.1 +9.8 9844 3 NFIB KLF17 THRB ETS1 GLIS2 ZNF366 EGR2 ZNF398 ZNF623 ZFP69B FOXO6 EXO5 LOC101929901 PIR34819 GC01P041369
GH01H041238 1.4 Ensembl ENCODE 16.8 -120.8 -120799 5.6 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 YBX1 YY1 SLC30A9 EXO5 ENSG00000235358 FOXO6 NFYC SCMH1 CTPS1 PIR51229
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FOXO6 on UCSC Golden Path with GeneCards custom track

Promoters for FOXO6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000005329 -422 1401 FOXA2 PKNOX1 ATF1 ZBTB7B GLIS2 ZNF143 FOS ATF7 SP3 SP5

Genomic Locations for FOXO6 Gene

Genomic Locations for FOXO6 Gene
21,670 bases
Plus strand

Genomic View for FOXO6 Gene

Genes around FOXO6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXO6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXO6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXO6 Gene

Proteins for FOXO6 Gene

  • Protein details for FOXO6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Forkhead box protein O6
    Protein Accession:

    Protein attributes for FOXO6 Gene

    492 amino acids
    Molecular mass:
    50595 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXO6 Gene

Post-translational modifications for FOXO6 Gene

  • Phosphorylation of Ser-184 is be important in regulating the transacriptional activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXO6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXO6 Gene

Domains & Families for FOXO6 Gene

Gene Families for FOXO6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FOXO6 Gene

Suggested Antigen Peptide Sequences for FOXO6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FOXO6: view

No data available for UniProtKB/Swiss-Prot for FOXO6 Gene

Function for FOXO6 Gene

Molecular function for FOXO6 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator.

Phenotypes From GWAS Catalog for FOXO6 Gene

Gene Ontology (GO) - Molecular Function for FOXO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISS --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 23714368
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXO6: view
genes like me logo Genes that share phenotypes with FOXO6: view

Animal Models for FOXO6 Gene

MGI Knock Outs for FOXO6:

miRNA for FOXO6 Gene

miRTarBase miRNAs that target FOXO6

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOXO6 Gene

Localization for FOXO6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXO6 Gene

Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. High nuclear localization after stimulation with growth factors (By similarity). {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXO6 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for FOXO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with FOXO6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FOXO6 Gene

Pathways & Interactions for FOXO6 Gene

SuperPathways for FOXO6 Gene

SuperPathway Contained pathways
1 FoxO signaling pathway
genes like me logo Genes that share pathways with FOXO6: view

Pathways by source for FOXO6 Gene

1 KEGG pathway for FOXO6 Gene

SIGNOR curated interactions for FOXO6 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for FOXO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA,ISS --
GO:0007613 memory IEA --
GO:0009653 anatomical structure morphogenesis IBA --
genes like me logo Genes that share ontologies with FOXO6: view

Drugs & Compounds for FOXO6 Gene

No Compound Related Data Available

Transcripts for FOXO6 Gene

mRNA/cDNA for FOXO6 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXO6 Gene

No ASD Table

Relevant External Links for FOXO6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FOXO6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOXO6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXO6 Gene

This gene is overexpressed in Pituitary (x6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FOXO6 Gene

NURSA nuclear receptor signaling pathways regulating expression of FOXO6 Gene:

genes like me logo Genes that share expression patterns with FOXO6: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXO6 Gene

Orthologs for FOXO6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FOXO6 Gene

Organism Taxonomy Gene Similarity Type Details
(Rattus norvegicus)
Mammalia Foxo6 33
  • 91.99 (n)
(Mus musculus)
Mammalia Foxo6 33 16 34
  • 91.65 (n)
(Ornithorhynchus anatinus)
Mammalia FOXO6 34
  • 74 (a)
(Canis familiaris)
Mammalia FOXO6 34
  • 62 (a)
(Bos Taurus)
Mammalia FOXO6 34
  • 45 (a)
(Monodelphis domestica)
Mammalia FOXO6 34
  • 39 (a)
(Gallus gallus)
Aves LOC100857767 33
  • 73.85 (n)
FOXO6 34
  • 31 (a)
(Anolis carolinensis)
Reptilia FOXO6 34
  • 30 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia foxo6 33
  • 65.4 (n)
(Danio rerio)
Actinopterygii si:ch211-206a7.2 33
  • 62.94 (n)
FOXO6 (2 of 2) 34
  • 28 (a)
FOXO6 (1 of 2) 34
  • 27 (a)
fruit fly
(Drosophila melanogaster)
Insecta foxo 34
  • 23 (a)
(Caenorhabditis elegans)
Secernentea daf-16 34
  • 21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HCM1 34
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3143 34
  • 18 (a)
Species where no ortholog for FOXO6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FOXO6 Gene

Gene Tree for FOXO6 (if available)
Gene Tree for FOXO6 (if available)

Paralogs for FOXO6 Gene

Paralogs for FOXO6 Gene

(2) SIMAP similar genes for FOXO6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FOXO6: view

Variants for FOXO6 Gene

Sequence variations from dbSNP and Humsavar for FOXO6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000024681 -- 41,383,494(+) GTGGC(C/G)GTGCC utr-variant-3-prime
rs1000042416 -- 41,383,764(+) CGCCT(A/G)CTGAG downstream-variant-500B
rs1000070231 -- 41,370,773(+) GAGAG(C/T)ACCCT intron-variant
rs1000176731 -- 41,366,056(+) TGGGG(C/T)TGGAA intron-variant
rs1000228298 -- 41,376,524(+) CCCTA(C/G)TCCTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FOXO6 Gene

Variant ID Type Subtype PubMed ID
nsv546104 CNV loss 21841781
nsv508171 CNV deletion 20534489
nsv1126196 CNV deletion 24896259
nsv1078372 CNV deletion 25765185
nsv1078367 CNV deletion 25765185
esv3410216 CNV insertion 20981092

Variation tolerance for FOXO6 Gene

Gene Damage Index Score: 8.36; 85.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXO6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXO6 Gene

Disorders for FOXO6 Gene

Relevant External Links for FOXO6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FOXO6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXO6 Gene

Publications for FOXO6 Gene

  1. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) Psychiatric GWAS Consortium Bipolar Disorder Working Group (Nature genetics 2011) 3 45 60
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  3. FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics. (PMID: 12857750) Jacobs FM … Smidt MP (The Journal of biological chemistry 2003) 2 3 60
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X … Chen J (Molecular systems biology 2015) 3 60
  5. FoxO6 inhibits cell proliferation in lung carcinoma through up-regulation of USP7. (PMID: 25695151) Hu HJ … Guo XX (Molecular medicine reports 2015) 3 60

Products for FOXO6 Gene

Sources for FOXO6 Gene

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