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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FOXO6 Gene

protein-coding   GIFtS: 34
GCID: GC01P041827          (predicted)

Forkhead Box O6

  Search for FOXO6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Forkhead Box O61 2
Forkhead Box Protein O62

External Ids:    HGNC: 248141   Entrez Gene: 1001320742   Ensembl: ENSG000002040607   OMIM: 6114575   UniProtKB: A8MYZ63   

Export aliases for FOXO6 gene to outside databases

Previous GC identifers: GC01U900892 GC01P041599


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FOXO6 Gene: 
FOXO6 (forkhead box O6) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is FOXM1.

UniProtKB/Swiss-Prot: FOXO6_HUMAN, A8MYZ6
Function: Transcriptional activator (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FOXO6 gene promoter:
         HOXA9B   HOXA9   Spz1   RP58   Tal-1   Nkx2-5   E47   HOXA5   STAT3   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FOXO6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXO6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.2   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p34.2

FOXO6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXO6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P041827:  view genomic region     (about GC identifiers)

Start:
41,827,227 bp from pter      End:
41,856,020 bp from pter
Size:
28,794 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FOXO6_HUMAN, A8MYZ6 (See protein sequence)
Recommended Name: Forkhead box protein O6  
Size: 492 amino acids; 50595 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=When phosphorylated, translocated
from nucleus to cytoplasm. High nuclear localization after stimulation with growth factors (By similarity)

Explore the universe of human proteins at neXtProt for FOXO6: NX_A8MYZ6

Explore proteomics data for FOXO6 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation of Ser-184 is be important in regulating the transacriptional activity (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A8MYZ6

  • FOXO6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FOXO6 Protein Expression

    ENSEMBL proteins: 
     ENSP00000361672  

    Human Recombinant Protein Products for FOXO6: 
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    Cloud-Clone Corp. Proteins for FOXO6 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    FOXO6 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FOX: Forkhead boxes

    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry A8MYZ6

    ProtoNet protein and cluster: A8MYZ6

    UniProtKB/Swiss-Prot: FOXO6_HUMAN, A8MYZ6
    Similarity: Contains 1 fork-head DNA-binding domain


    FOXO6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOXO6_HUMAN, A8MYZ6
    Function: Transcriptional activator (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI--
    GO:0043565sequence-specific DNA binding IEA--
         
    FOXO6 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Foxo6):
     behavior/neurological  nervous system 

    FOXO6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Foxo6tm1Abru for FOXO6

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FOXO6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FOXO6

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOXO6

    1 Interacting protein for FOXO6 (A8MYZ62) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HNF4AP412352MINT-8430144 MINT-8429213
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----

    FOXO6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FOXO6

    Search CenterWatch for drugs/clinical trials and news about FOXO6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000372591
    miRNA
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    Inhib. RNA
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    Browse OriGene RNAi
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXO6
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FOXO6 expression in normal human tissues (normalized intensities)      FOXO6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FOXO6 Expression
    About this image


    FOXO6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Smooth Muscle (Muscoskeletal System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Blood Brain Barrier (Nervous System)
             Postnatal Endothelial Cells Blood Brain Barrier
     
     Testis (Reproductive System)
             sperm   
     
     Endothelium (Cardiovascular System)
             Postnatal Endothelial Cells Blood Brain Barrier

    See FOXO6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FOXO6
        SABiosciences Custom PCR Arrays for FOXO6
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXO6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FOXO6 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Foxo61 , 5 forkhead box O61, 5 85.57(n)1
    88.21(a)1
      4 (56.10 cM)5
    3299341  NM_194060.11  NP_918949.11 
     1202670795 
    chicken
    (Gallus gallus)
    Aves LOC1008577671 forkhead box protein O3-like 69.82(n)
    64.79(a)
      100857767  XM_003642563.1  XP_003642611.1 
    lizard
    (Anolis carolinensis)
    Reptilia FOXO66
    Uncharacterized protein
    28(a)
    1 ↔ 1
    GL343563.1(341026-342582)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5615411 forkhead box protein O6-like 61(n)
    56.3(a)
      561541  XM_684949.1  XP_690041.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fd102C6
    foxo6
    forkhead box, sub-group O
    9(a)
    21(a)
    possible ortholog
    1 ↔ many
    4(857610-865132)
    3R(9882690-9913700)
    worm
    (Caenorhabditis elegans)
    Secernentea fkh-106
    daf-166
    Forkhead box protein O
    22(a)
    19(a)
    possible ortholog
    1 ↔ many
    I(10163475-10165135)
    I(10750343-10776700)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HCM16
    Forkhead transcription factor that drives S-phase ...
    10(a)
    1 → many
    III(229310-231004)


    ENSEMBL Gene Tree for FOXO6 (if available)
    TreeFam Gene Tree for FOXO6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FOXO6 gene
    FOXM12  FOXO42  FOXO32  FOXO12  
    2 SIMAP similar genes for FOXO6 using alignment to 2 protein entries:     FOXO6_HUMAN (see all proteins):
    FOXO4    FKHRL1P2

    FOXO6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/503 SNPs in FOXO6 are shown (see all 503)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1868346251,2
    --39944075(+) GGTGGC/GGGTGG 2 R G mis10--------
    rs1807899131,2
    --39948946(+) CCCTCA/GCTCCC 1 -- int10--------
    rs717156351,2
    C--41828124(+) GGCAC-/CCCCCC 1 -- int10--------
    rs355104741,2
    C--41833312(+) TTTTT-/TCTGAG 1 -- int12Minor allele frequency- T:0.25NA 4
    rs559245161,2
    C--41841149(+) AAAGA-/AAGAAAG
    AAAGAAAGA
    GGAAA
    1 -- int11Minor allele frequency- AAGAAAGAAAGAAAGA:0.00NA 2
    rs562025161,2
    C--41846597(+) GGGGAC/-CCCCA 1 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs120928251,2
    C--41848060(+) caccgC/Tcgggc 2 P S mis1 ese30--------
    rs1141780431,2
    C,F--41895907(+) ACAAGC/ATGACT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1830438501,2
    C--41895921(+) AAAGGC/TGTTGG 1 -- us2k10--------
    rs798810191,2
    C,F--41896256(+) GGGGAC/TGGAGG 1 -- us2k11Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for FOXO6 (41827227 - 41856020 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FOXO6: --
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing FOXO6
    DNA2.0 Custom Variant and Variant Library Synthesis for FOXO6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FOXO6 for disorders           About MalaCards
    OMIM gene information: 611457    OMIM disorders: --


    FOXO6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FOXO6
    Human Genome Epidemiology (HuGE) Navigator: FOXO6 (1 document)

    Export disorders for FOXO6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FOXO6 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FOXO6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Large-scale genome-wide association analysis of bipol ar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1, 4 Sklar P....Purcell S.M. (2011)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics. (PubMed id 12857750)1, 3 Jacobs F.M....Smidt M.P. (2003)
    4. FOXO6 promotes gastric cancer cell tumorigenicity via upregulation of C-myc. (PubMed id 23714368)1 Qinyu L....Cheng-hong P. (2013)
    5. FoxO transcription factors; Regulation by AKT and 14- 3-3 proteins. (PubMed id 21708191)1 Tzivion G....Ramakrishnan G. (2011)
    6. Candidate gene study of FOXO1, FOXO4, and FOXO6 revea ls no association with human longevity in Germans. (PubMed id 21388494)1 Kleindorp R....Nebel A. (2011)
    7. FoxO6 integrates insulin signaling with gluconeogenes is in the liver. (PubMed id 21940782)1 Kim D.H....Dong H.H. (2011)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 100132074 HGNC: 24814 Ensembl:ENSG00000204060 euGenes: HUgn100132074 ECgene: FOXO6
    H-InvDB: FOXO6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FOXO6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FOXO6 gene:
    Search GeneIP for patents involving FOXO6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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