FOXO6 Gene
protein-coding GIFtS: 33
GCID: GC01P041827 (predicted)
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forkhead box O6
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Aliases
for FOXO6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Forkhead Box O61 2 | | Forkhead Box Protein O62 |
Export aliases for FOXO6 gene to outside databasesPrevious GC identifers: GC01U900892 GC01P041599 |
Summaries
for FOXO6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FOXO6_HUMAN, A8MYZ6Function: Transcriptional activator (By similarity)
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Genomic Views
for FOXO6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FOXO6 gene promoter:
HOXA9B HOXA9 Spz1 RP58 Tal-1 Nkx2-5 E47 HOXA5 STAT3 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FOXO6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXO6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p34.2 Ensembl cytogenetic band: 1p34.2 HGNC cytogenetic band: 1p34.2FOXO6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P041827: view genomic region
(about GC identifiers)
Start:
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41,827,227 bp from pter |
End:
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41,849,262 bp from pter |
Size:
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22,036 bases |
Orientation:
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plus strand |
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Proteins
for FOXO6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FOXO6_HUMAN, A8MYZ6 (See
protein sequence)Recommended Name: Forkhead box protein O6 Size: 492 amino acids; 50595 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=When phosphorylated, translocated fromnucleus to cytoplasm. High nuclear localization after stimulation with growth factors (By similarity)Explore the universe of human proteins at neXtProt for FOXO6: NX_A8MYZ6
Post-translational modifications:
Phosphorylation of Ser-184 is be important in regulating the transacriptional activity (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A8MYZ6
FOXO6 Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000361672
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
FOXO6 for ontologies About GeneDecksing
FOXO6 Antibody Products:
Assay Products for FOXO6: |
Protein
Domains /
Families
for FOXO6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FOXO6 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A8MYZ6ProtoNet protein and cluster: A8MYZ6 UniProtKB/Swiss-Prot: FOXO6_HUMAN, A8MYZ6Similarity: Contains 1 fork-head DNA-binding domain |
Function
for FOXO6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FOXO6_HUMAN, A8MYZ6Function: Transcriptional activator (By similarity)
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXO6 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003690 | double-stranded DNA binding |
IBA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
-- | -- | | GO:0003705 | RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity |
IBA | -- | | GO:0008134 | transcription factor binding |
IBA | -- | | GO:0008301 | DNA binding, bending |
IBA | -- |
FOXO6 for ontologies About GeneDecksing
|
Pathways & Interactions
for FOXO6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOXO6
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
-- | -- | | GO:0006974 | response to DNA damage stimulus |
IBA | -- | | GO:0007389 | pattern specification process |
IBA | -- | | GO:0008285 | negative regulation of cell proliferation |
IBA | -- | | GO:0008286 | insulin receptor signaling pathway |
IBA | -- |
FOXO6 for ontologies About GeneDecksing
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Drugs & Compounds
for FOXO6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FOXO6
Search CenterWatch for drugs/clinical trials and news about FOXO6 
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Transcripts
for FOXO6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000372591
GeneLoc Exon Structure
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Expression
for FOXO6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FOXO6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See FOXO6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FOXO6
SABiosciences Custom PCR Arrays for FOXO6
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FOXO6 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXO6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXO6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXO6 |
Orthologs
for FOXO6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for FOXO6 gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for FOXO6 (if available)
TreeFam Gene Tree for FOXO6 (if available) |
Paralogs
for FOXO6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FOXO6 gene
- FOXO42 FOXO32 FOXO12
3 SIMAP similar genes for FOXO6 using alignment to 2 protein entries: FOXO6_HUMAN (see all proteins):FOXO4 FKHRL1P2 FOXO3
FOXO6 for paralogs About GeneDecksing
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Genomic Variants
for FOXO6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FOXO6 (41827227 - 41849262 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FOXO6: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for FOXO6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 FOXO6 for disorders About MalaCards
FOXO6 for disorders About GeneDecksing
OMIM gene information: 611457
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: FOXO6 (1 document)
Export disorders for FOXO6 gene to outside databases
|
Publications
for FOXO6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FOXO6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FOXO6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics. (PubMed id 12857750)1, 3 Jacobs F.M....Smidt M.P. (2003)
- Large-scale genome-wide association analysis of bipol ar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1 Sklar P....Purcell S.M. (2011)
- FoxO transcription factors; Regulation by AKT and 14- 3-3 proteins. (PubMed id 21708191)1 Tzivion G....Ramakrishnan G. (2011)
- Candidate gene study of FOXO1, FOXO4, and FOXO6 revea ls no association with human longevity in Germans. (PubMed id 21388494)1 Kleindorp R....Nebel A. (2011)
- FoxO6 integrates insulin signaling with gluconeogenes is in the liver. (PubMed id 21940782)1 Kim D.H....Dong H.H. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
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External Searches for FOXO6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing FOXO6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing FOXO6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FOXO6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FOXO6 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for FOXO6 gene:
Search GeneIP for patents involving FOXO6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FOXO6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FOXO6 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOXO6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXO6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXO6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXO6 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXO6 |
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| | | | Search Tocris compounds for FOXO6 |
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 | | | FOXO6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXO6 |
|  |  |  | | | | Search ThermoFisher Antibodies for FOXO6 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FOXO6 |
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