Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FOXO6 Gene

Aliases for FOXO6 Gene

  • Forkhead Box O6 2 3

External Ids for FOXO6 Gene

Summaries for FOXO6 Gene

GeneCards Summary for FOXO6 Gene

FOXO6 (Forkhead Box O6) is a Protein Coding gene. Among its related pathways are FoxO signaling pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is FOXO4.

UniProtKB/Swiss-Prot for FOXO6 Gene

  • Transcriptional activator.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXO6 Gene

Genomics for FOXO6 Gene

Genomic Location for FOXO6 Gene

Start:
41,361,656 bp from pter
End:
41,383,591 bp from pter
Size:
21,936 bases
Orientation:
Plus strand

Genomic View for FOXO6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXO6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXO6 Gene

Regulatory Elements for FOXO6 Gene

Proteins for FOXO6 Gene

  • Protein details for FOXO6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MYZ6-FOXO6_HUMAN
    Recommended name:
    Forkhead box protein O6
    Protein Accession:
    A8MYZ6
    Secondary Accessions:

    Protein attributes for FOXO6 Gene

    Size:
    492 amino acids
    Molecular mass:
    50595 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXO6 Gene

Proteomics data for FOXO6 Gene at MOPED

Post-translational modifications for FOXO6 Gene

  • Phosphorylation of Ser-184 is be important in regulating the transacriptional activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXO6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXO6 Gene

Domains for FOXO6 Gene

Gene Families for FOXO6 Gene

HGNC:
  • FOX :Forkhead boxes

Protein Domains for FOXO6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FOXO6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MYZ6

UniProtKB/Swiss-Prot:

FOXO6_HUMAN
Domain:
  • Contains 1 fork-head DNA-binding domain.:
    • A8MYZ6
genes like me logo Genes that share domains with FOXO6: view

Function for FOXO6 Gene

Molecular function for FOXO6 Gene

UniProtKB/Swiss-Prot Function: Transcriptional activator.

Gene Ontology (GO) - Molecular Function for FOXO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 23714368
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXO6: view

Phenotypes for FOXO6 Gene

genes like me logo Genes that share phenotypes with FOXO6: view

Animal Models for FOXO6 Gene

MGI Knock Outs for FOXO6:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for FOXO6 Gene

Localization for FOXO6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXO6 Gene

Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. High nuclear localization after stimulation with growth factors (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXO6 Gene COMPARTMENTS Subcellular localization image for FOXO6 gene
Compartment Confidence
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for FOXO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with FOXO6: view

Pathways for FOXO6 Gene

SuperPathways for FOXO6 Gene

Superpath Contained pathways
1 FoxO signaling pathway
genes like me logo Genes that share pathways with FOXO6: view

Pathways by source for FOXO6 Gene

1 KEGG pathway for FOXO6 Gene

Gene Ontology (GO) - Biological Process for FOXO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with FOXO6: view

Transcripts for FOXO6 Gene

mRNA/cDNA for FOXO6 Gene

(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for FOXO6 Gene

No ASD Table

Relevant External Links for FOXO6 Gene

GeneLoc Exon Structure for
FOXO6
ECgene alternative splicing isoforms for
FOXO6

Expression for FOXO6 Gene

mRNA expression in normal human tissues for FOXO6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXO6 Gene

This gene is overexpressed in Pituitary (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FOXO6 Gene

genes like me logo Genes that share expressions with FOXO6: view

No data available for mRNA Expression by UniProt/SwissProt for FOXO6 Gene

Orthologs for FOXO6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FOXO6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOXO6 36
  • 45 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXO6 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxo6 35
  • 91.65 (n)
  • 95.96 (a)
Foxo6 16
Foxo6 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FOXO6 36
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOXO6 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxo6 35
  • 91.99 (n)
  • 96.16 (a)
chicken
(Gallus gallus)
Aves FOXO6 36
  • 31 (a)
OneToOne
LOC100857767 35
  • 73.85 (n)
  • 69.52 (a)
lizard
(Anolis carolinensis)
Reptilia FOXO6 36
  • 30 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia foxo6 35
  • 65.4 (n)
  • 73.65 (a)
zebrafish
(Danio rerio)
Actinopterygii FOXO6 (1 of 2) 36
  • 27 (a)
OneToMany
FOXO6 (2 of 2) 36
  • 28 (a)
OneToMany
si:ch211-206a7.2 35
  • 62.94 (n)
  • 61.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta foxo 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea daf-16 36
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HCM1 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3143 36
  • 18 (a)
OneToMany
Species with no ortholog for FOXO6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FOXO6 Gene

ENSEMBL:
Gene Tree for FOXO6 (if available)
TreeFam:
Gene Tree for FOXO6 (if available)

Paralogs for FOXO6 Gene

Paralogs for FOXO6 Gene

Selected SIMAP similar genes for FOXO6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FOXO6: view

Variants for FOXO6 Gene

Sequence variations from dbSNP and Humsavar for FOXO6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1317557 -- 41,373,670(-) CCAAA(A/G)GAAGG intron-variant
rs1317558 -- 41,373,411(-) ACACT(A/G)TTCCC intron-variant
rs1892423 -- 41,383,668(-) GCACA(G/T)GAACC downstream-variant-500B
rs2364543 -- 41,367,417(+) AGAGT(G/T)GGGGG intron-variant
rs2364544 -- 41,367,490(+) GTTCA(A/G)ATCAG intron-variant

Relevant External Links for FOXO6 Gene

HapMap Linkage Disequilibrium report
FOXO6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FOXO6 Gene

Disorders for FOXO6 Gene

Relevant External Links for FOXO6

Genetic Association Database (GAD)
FOXO6
Human Genome Epidemiology (HuGE) Navigator
FOXO6
genes like me logo Genes that share disorders with FOXO6: view

No data available for UniProtKB/Swiss-Prot for FOXO6 Gene

Publications for FOXO6 Gene

  1. FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics. (PMID: 12857750) Jacobs F.M. … Smidt M.P. (J. Biol. Chem. 2003) 2 3
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) (Nat. Genet. 2011) 3 48
  4. FoxO6 integrates insulin signaling with gluconeogenesis in the liver. (PMID: 21940782) Kim D.H. … Dong H.H. (Diabetes 2011) 3
  5. FoxO6 in glucose metabolism (FoxO6). (PMID: 23324123) Kim D.H. … Dong H.H. (J Diabetes 2013) 3

Products for FOXO6 Gene

Sources for FOXO6 Gene

Back to Top

Content