Aliases for FOXO4 Gene
External Ids for FOXO4 Gene
Previous HGNC Symbols for FOXO4 Gene
Previous GeneCards Identifiers for FOXO4 Gene
This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
GeneCards Summary for FOXO4 Gene
FOXO4 (Forkhead Box O4) is a Protein Coding gene. Diseases associated with FOXO4 include sarcomatoid squamous cell skin carcinoma and myeloid/lymphoid or mixed lineage leukemia. Among its related pathways are PI3K/AKT Signaling in Cancer and Immune System. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and enzyme binding. An important paralog of this gene is FOXO6.
UniProtKB/Swiss-Prot for FOXO4 Gene
Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.