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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FOXO4 Gene

protein-coding   GIFtS: 61
GCID: GC0XP070316

forkhead box O4

(Previous names: myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila)...)
(Previous symbol: MLLT7)
 Explore 26 diseases affiliated with
FOXO4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FOXO4    

Aliases
for FOXO4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Forkhead Box O41 2     Fork Head Domain Transcription Factor AFX12 3
AFX11 2 3 5     AFX2 3
MLLT71 2 3 5     Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax (Drosophila) Homolog);
Translocated To, 71
Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila);
Translocated To, 71 2
     Forkhead Box Protein O42

External Ids:    HGNC: 71391   Entrez Gene: 43032   Ensembl: ENSG000001844817   OMIM: 3000335   UniProtKB: P981773   

Export aliases for FOXO4 gene to outside databases

Previous GC identifers: GC0XP070233 GC0XP064135


Summaries
for FOXO4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FOXO4:
This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by
this class are regulated by factors involved in growth and differentiation indicating they play a role in these
processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene,
encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Jan 2010)

UniProtKB/Swiss-Prot: FOXO4_HUMAN, P98177
Function: Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response
elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses
hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell
cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in
ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity

Gene Wiki entry for FOXO4


Genomic Views
for FOXO4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011669.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FOXO4 gene promoter:
         GR   Tal-1   GR-beta   E47   Evi-1   IRF-2   HFH-1   c-Myb   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FOXO4 promoter sequence
   Search SABiosciences Chromatin IP Primers for FOXO4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXO4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.1   Ensembl cytogenetic band:  Xq13.1   HGNC cytogenetic band: Xq13.1

FOXO4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXO4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP070316:  view genomic region     (about GC identifiers)

Start:
 70,315,999 bp from pter      End:
 70,323,385 bp from pter
Size:
 7,387 bases      Orientation:
 plus strand

Proteins
for FOXO4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FOXO4_HUMAN, P98177 (See protein sequence)
Recommended Name: Forkhead box protein O4  
Size: 505 amino acids; 53684 Da
Subunit: Interacts with CREBBP/CBP, CTNNB1, MYOCD, SIRT1, SRF and YWHAZ. Acetylated by CREBBP/CBP and deacetylated by
SIRT1. Binding of YWHAZ inhibits DNA-binding. Interacts with USP7; the interaction is enhanced in presence of hydrogen
peroxide and occurs independently of TP53. Interacts with NLK, and this inhibits monoubiquitination and
transcriptional activity
Subcellular location: Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm.
Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When
deubiquitinated, translocated from nucleus to cytoplasm
2 PDB 3D structures from and Proteopedia for FOXO4:
1E17 (3D)        3L2C (3D)    
Secondary accessions: B7WPJ7 O43821 Q13720 Q3KPF1 Q8TDK9
Alternative splicing: 2 isoforms:  P98177-1   P98177-2   

Explore the universe of human proteins at neXtProt for FOXO4: NX_P98177

Post-translational modifications:

  • Acetylation by CREBBP/CBP, which is induced by peroxidase stress, inhibits transcriptional activity. Deacetylation by
    • SIRT1 is NAD-dependent and stimulates transcriptional activity1
  • Phosphorylation by PKB/AKT1 inhibits transcriptional activity and is responsible for cytoplasmic localization. May be
    • phosphorylated at multiple sites by NLK1
  • Monoubiquitinated; monoubiquitination is induced by oxidative stress and reduced by deacetylase inhibitors; results in
    • its relocalization to the nucleus and its increased transcriptional activity. Deubiquitinated by USP7;
    deubiquitination is induced by oxidative stress; enhances its interaction with USP7 and consequently,
    deubiquitination; increases its translocation to the cytoplasm and inhibits its transcriptional activity.
    Hydrogene-peroxide-induced ubiquitination and USP7-mediated deubiquitination have no major effect on its protein
    stability1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P98177

    • FOXO4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001164402.1  NP_005929.2  

    ENSEMBL proteins: 
     ENSP00000363377   ENSP00000342209  
    Reactome Protein details: P98177
    Human Recombinant Protein Products: 
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    Novus Biologicals FOXO4 Proteins
    Novus Biologicals FOXO4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FOXO4

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS--
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IBA--
    GO:0005737cytoplasm IDA16964248
    GO:0005829cytosol TAS--


    FOXO4 for ontologies           About GeneDecksing



    FOXO4 Antibody Products: 
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    Uscn ELISAs and CLIAs for FOXO4

    Protein Domains /
    Families
    for FOXO4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FOXO4 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry P98177

    ProtoNet protein and cluster: P98177

    UniProtKB/Swiss-Prot: FOXO4_HUMAN, P98177
    Similarity: Contains 1 fork-head DNA-binding domain


    Function
    for FOXO4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FOXO4_HUMAN, P98177
    Function: Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response
    elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses
    hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell
    cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in
    ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity

    10/913 SABiosciences Target genes for FOXO4 (see all 913):
    AADAC AADACL2 ABCB11 ACO1 ACP6 ACSF2 ACSL1 ADAMDEC1 ADCY3 ADCY8

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOXO4
    8/76 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXO4 (see all 76):
    hsa-miR-640 hsa-miR-1321 hsa-miR-193a-3p hsa-miR-605 hsa-miR-128 hsa-miR-637 hsa-miR-149 hsa-miR-508-5p
    SwitchGear 3'UTR luciferase reporter plasmid: FOXO4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOXO4 (see all 7)
    OriGene shRNA RFP: FOXO4
    OriGene siRNA: FOXO4
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for FOXO4

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXO4 (see all 4)
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXO4 

    Cell Line
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    Search LifeMap BioReagents cell lines for FOXO4

    In Situ Assay
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    Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001071nucleic acid binding transcription factor activity IMP--
    GO:0003677DNA binding IDA10783894
    GO:0003690double-stranded DNA binding IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity IDA10783894
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IBA--


    FOXO4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for FOXO4:
     Reduced beta-catenin activity  

    Animal Models:
         Mouse knock-outs for FOXO4: Foxo4tm1Kca Foxo4tm1.1Rdp
         3 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Foxo4):
     mortality/aging  normal  tumorigenesis 

    FOXO4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FOXO4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    2PIP3 activates AKT signaling
    8/10 pathways (see all 10)
    		PIP3 activates AKT signaling1.00
    		PI3K/AKT activation0.97
    		PI3K/AKT Signaling in Cancer1.00
    		GAB1 signalosome0.96
    		PI3K events in ERBB2 signaling1.00
    		Constitutive PI3K/AKT Signaling in Cancer0.88
    		PI3K events in ERBB4 signaling1.00
    		Signaling by SCF-KIT0.72
    3IL-9 Signaling Pathways
    		IL-9 Signaling Pathways1.00
    		IL-2 Signaling Pathways0.88
    		IL-21 Signaling Pathways0.90
    		IL-15 Signaling Pathways0.86
    		IL-7 Signaling Pathways0.90
    		IL-4 Signaling Pathways0.80
    		Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    4Immune System
    		Immune System1.00
    		Innate Immune System0.46
    		Adaptive Immune System0.59
    5Signaling by the B Cell Receptor (BCR)
    		Signaling by the B Cell Receptor (BCR)1.00
    		Downstream Signaling Events Of B Cell Receptor (BCR)0.81

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/7 R&D Systems Pathways for FOXO4 (see all 7)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-9 Signaling Pathways
    IL-4 Signaling Pathways
    IL-15 Signaling Pathways


    1 Cell Signaling Technology (CST) Pathway for FOXO4
        PI3K / Akt Signaling

    5/8 BioSystems Pathways for FOXO4 (see all 8) 
        AGE/RAGE pathway
    Signaling Pathways in Glioblastoma
    IL-6 Signaling Pathway
    TGF-beta Receptor Signaling Pathway
    Regulation of nuclear SMAD2/3 signaling

    5/30        Reactome Pathways for FOXO4 (see all 30)
        AKT phosphorylates targets in the nucleus
    Signaling by EGFR in Cancer
    Disease
    Signaling by ERBB2
    GAB1 signalosome



    FOXO4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FOXO4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/43 Interacting proteins for FOXO4 (P981771, 2, 3 ENSP000003633774) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIRT1Q96EB61, 3, ENSP000002120154EBI-4481939,EBI-1802965 I2D: score=1 STRING: ENSP00000212015
    YWHAZP631042, 3, ENSP000003095034MINT-8006602 MINT-8006595 I2D: score=4 STRING: ENSP00000309503
    OGTO152942, 3, ENSP000003628244MINT-7299691 I2D: score=1 STRING: ENSP00000362824
    SMAD3P840223, ENSP000003329734I2D: score=4 STRING: ENSP00000332973
    MDM2Q009873, ENSP000004172814I2D: score=1 STRING: ENSP00000417281
    About this table

    Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000080G1 phase of mitotic cell cycle IDA10783894
    GO:0006355regulation of transcription, DNA-dependent IDA15126506
    GO:0006366transcription from RNA polymerase II promoter TAS10783894
    GO:0007050cell cycle arrest IDA10783894
    GO:0007095mitotic cell cycle G2/M transition DNA damage checkpoint IBA--


    FOXO4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FOXO4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FOXO4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FOXO4
    UniProtKB/Swiss-Prot: FOXO4_HUMAN, P98177
    Pharmaceutical: A constitutively active FOXO4 mutant where phosphorylation sites Thr-32, Ser-197 and Ser-262 have been
    mutated to alanine may have therapeutic potential in ERBB2/HER2-overexpressing cancers as it inhibits ERBB2-mediated
    cell survival, transformation and tumorigenicity


    1 HMDB Compound for FOXO4    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    3 Novoseek chemical compound relationships for FOXO4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wortmannin 51.9 2 10518537 (2)
    phosphatidylinositol 50.8 1 10518537 (1)
    glycogen 24 1 16973122 (1)

    Search CenterWatch for drugs/clinical trials and news about FOXO4 

    Transcripts
    for FOXO4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FOXO4 gene (2 alternative transcripts): 
    NM_001170931.1  NM_005938.3  

    Unigene Cluster for FOXO4:

    Forkhead box O4
    Hs.584654  [show with all ESTs]
    Unigene Representative Sequence: NM_005938
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374259(uc004dyt.2 uc004dys.2) ENST00000466874 ENST00000341558
    ENST00000464598 ENST00000469736

    miRNA
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    hsa-miR-640 hsa-miR-1321 hsa-miR-193a-3p hsa-miR-605 hsa-miR-128 hsa-miR-637 hsa-miR-149 hsa-miR-508-5p
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF384029.1 AK300142.1 BC026735.1 BC106761.2 U10072.1 X93996.1 

    2 DOTS entries:

    DT.109928  DT.95141199 

    24/57 AceView cDNA sequences (see all 57):

    AL552503 BQ021921 BM672472 AL532357 CR620527 CK430063 BQ278065 BE732899 
    BP349083 CR596165 T54418 BM724728 AL541001 AW027741 BC026735 AW075830 
    CR595958 AW292413 AL575789 BE350669 AL544994 NM_005938 BX402597 X93996 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FOXO4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5
    SP1:                    -                     
    SP2:                    -                     
    SP3:                                          


    ECgene alternative splicing isoforms for FOXO4

    Expression
    for FOXO4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FOXO4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCTAGATTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See FOXO4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FOXO4

    SOURCE GeneReport for Unigene cluster: Hs.584654

    UniProtKB/Swiss-Prot: FOXO4_HUMAN, P98177
    Tissue specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform zeta is most
    abundant in the liver, kidney, and pancreas

        SABiosciences Expression via Pathway-Focused PCR Array including FOXO4: 
              Angiogenic Growth Factors in human mouse rat

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    In Situ
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    Orthologs
    for FOXO4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FOXO4 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Foxo41 , 5 forkhead box O41, 5 88.36(n)1
    88.69(a)1    		   X (43.89 cM)5
    546011  NM_018789.21  NP_061259.11 
     1012545285 
    chicken
    (Gallus gallus)    		 Aves FOXO41 forkhead box O4 61.77(n)
    61.3(a)    		   428703  XM_426261.3  XP_426261.3 
    lizard
    (Anolis carolinensis)    		 Reptilia FOXO46
    		 --
    		 53(a)
    		 1 ↔ 1
    		 GL343758.1(160087-175345)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5637191 forkhead box protein O1-like 59.09(n)
    56.9(a)    		   563719  XM_687076.5  XP_692168.4 
    fruit fly
    (Drosophila melanogaster)    		 Insecta foxo6
    		 forkhead box, sub-group O
    		 23(a)
    		 1 → many
    		 3R(9882690-9913700)
    worm
    (Caenorhabditis elegans)    		 Secernentea daf-166
    		 Forkhead box protein O
    		 23(a)
    		 1 → many
    		 I(10750332-10776689)


    ENSEMBL Gene Tree for FOXO4 (if available)
    TreeFam Gene Tree for FOXO4 (if available) 

    Paralogs
    for FOXO4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FOXO4 gene
    FOXO62  FOXO32  FOXO12  
    4 SIMAP similar genes for FOXO4 using alignment to 1 protein entry:     FOXO4_HUMAN:
    FOXO6    DKFZp781A0677    FOXO1    FOXO3

    FOXO4 for paralogs           About GeneDecksing



    Genomic Variants
    for FOXO4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/94 NCBI SNPs in FOXO4 are shown (see all 94)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1820333421,2
    		--70314050(+) AGGAAA/GGAAGG 2 -- us2k10--------
    rs2001582191,2
    		--70314093(+) AAGGA-/AGGAAGG 2 -- us2k10--------
    rs59810701,2
    		C,A,H--70314170(+) aagaaA/Ggaagg 2 -- us2k1 tfbs3 trp30--------
    rs2005806101,2
    		--70314171(+) GAAAG-/AAAGGA 2 -- us2k10--------
    rs2016907081,2
    		--70314189(+) AGAAA-/GAAG  
                GAAGG     		2 -- us2k10--------
    rs59807401,2
    		C,--70314204(+) AGGAAA/GGAAAG 2 -- us2k1 trp30--------
    rs1490578881,2
    		--70314314(+) GTTAGC/TGTCTT 2 -- us2k10--------
    rs59807411,2
    		C,F,H,--70314419(+) AATTTG/TCACAG 2 -- us2k112Minor allele frequency- T:0.17NS EA WA NA 1648
    rs1876410661,2
    		--70314632(+) ATGATA/CTTGGC 2 -- us2k10--------
    rs726288941,2
    		C,--70314657(+) ACCTCC/TTGGGT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for FOXO4 (70315999 - 70323385 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for FOXO4
         1 CNV: 7797
    Locus Specific Mutation Databases (LSDB): FOXO4

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for FOXO4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FOXO4 for disorders           About GeneDecksing

    OMIM gene information: 300033    OMIM disorders: --

    UniProtKB/Swiss-Prot: FOXO4_HUMAN, P98177
  • Note=A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X;11)(q13;q23) with
    • MLL/HRX. The result is a rogue activator protein

    20/26 diseases for FOXO4 (see all 26):    About MalaCards
    leukemia    x-linked dystonia-parkinsonism    human t-cell leukemia virus type 1    fibrous histiocytoma
    cutaneous fibrous histiocytoma    spinocerebellar ataxia type 3    malignant spindle cell melanoma    spinocerebellar ataxia
    histiocytoma    acute lymphoblastic leukemia    lymphoblastic leukemia    dermatofibrosarcoma
    acute leukemia    t-cell leukemia    leiomyosarcoma    ataxia
    hepatitis b    skin cancer    colon cancer    colorectal cancer

    6 diseases from the University of Copenhagen DISEASES database for FOXO4:
    Malignant fibroxanthoma     Dermatofibrosarcoma     Cutaneous fibrous histiocytoma     Squamous cell carcinoma
    Melanoma     Fibrous histiocytoma

    3 Novoseek disease relationships for FOXO4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acute leukemia 33.6 3 9010221 (3)
    tumors 0 4 18648506 (2), 17599731 (1)
    cancer 0 7 15688030 (2), 11353388 (1), 9010221 (1)

    Human Genome Epidemiology (HuGE) Navigator: FOXO4 (2 documents)

    Export disorders for FOXO4 gene to outside databases

    Publications
    for FOXO4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FOXO4 gene, integrated from 9 sources (see all 78):
    (articles sorted by number of sources associating them with FOXO4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the t(X;11) breakpoint from a leukemic cell line identify a new member of the forkhead gene family. (PubMed id 7529552)1, 2, 3 Parry P.... Evans G. (1994)
    2. Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23). (PubMed id 9010221)1, 2, 9 Borkhardt A.... Lampert F. (1997)
    3. Constitutively active FOXO4 inhibits Akt activity, regulates p27 Kip1 stability, and suppresses HER2-mediated tumorigenicity. (PubMed id 15688030)1, 2, 9 Yang H.... Lee M.-H. (2005)
    4. Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin. (PubMed id 16054032)1, 2, 9 Liu Z.-P.... Olson E.N. (2005)
    5. Solution structure of the DNA binding domain of the human forkhead transcription factor AFX (FOXO4). (PubMed id 11352721)1, 2, 9 Weigelt J.... Wikstrom M. (2001)
    6. Regulation of intracellular localization and transcriptional activity of FOXO4 by protein kinase B through phosphorylation at the motif sites conserved among the FOXO family. (PubMed id 16272144)1, 2, 9 Matsuzaki H.... Kikkawa U. (2005)
    7. Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B. (PubMed id 10518537)1, 2, 9 Takaishi H.... Nishizuka Y. (1999)
    8. Oxidative stress-dependent regulation of Forkhead box O4 activity by nemo-like kinase. (PubMed id 20874444)1, 2 Szypowska A.A....Burgering B.M.T. (2011)
    9. FOXO4 transcriptional activity is regulated by monoub iquitination and USP7/HAUSP. (PubMed id 16964248)1, 2 van der Horst A....Burgering B.M. (2006)
    10. 14-3-3 protein interacts with nuclear localization sequence of forkhead transcription factor FoxO4. (PubMed id 16114898)1, 2 Obsilova V.... Obsil T. (2005)

    External Searches for FOXO4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FOXO4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4303 HGNC: 7139 AceView: MLLT7 Ensembl:ENSG00000184481 euGenes: HUgn4303
    ECgene: FOXO4 H-InvDB: FOXO4

    Other Databases showing FOXO4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FOXO4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FOXO4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FOXO4 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for FOXO4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FOXO4 gene:
    Search GeneIP for patents involving FOXO4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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