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Aliases for FOXO4 Gene

Aliases for FOXO4 Gene

  • Forkhead Box O4 2 3
  • MLLT7 3 4 6
  • AFX1 3 4 6
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated To, 7 2 3
  • Fork Head Domain Transcription Factor AFX1 3 4
  • AFX 3 4
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax (Drosophila) Homolog); Translocated To, 7 2
  • Forkhead Box Protein O4 3

External Ids for FOXO4 Gene

Previous HGNC Symbols for FOXO4 Gene

  • MLLT7

Previous GeneCards Identifiers for FOXO4 Gene

  • GC0XP070233
  • GC0XP070316
  • GC0XP064135

Summaries for FOXO4 Gene

Entrez Gene Summary for FOXO4 Gene

  • This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

GeneCards Summary for FOXO4 Gene

FOXO4 (Forkhead Box O4) is a Protein Coding gene. Diseases associated with FOXO4 include cutaneous fibrous histiocytoma and malignant fibroxanthoma. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is FOXO6.

UniProtKB/Swiss-Prot for FOXO4 Gene

  • Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.

Gene Wiki entry for FOXO4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXO4 Gene

Genomics for FOXO4 Gene

Regulatory Elements for FOXO4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FOXO4 Gene

Start:
71,096,149 bp from pter
End:
71,103,535 bp from pter
Size:
7,387 bases
Orientation:
Plus strand

Genomic View for FOXO4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXO4 Gene

Proteins for FOXO4 Gene

  • Protein details for FOXO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P98177-FOXO4_HUMAN
    Recommended name:
    Forkhead box protein O4
    Protein Accession:
    P98177
    Secondary Accessions:
    • B7WPJ7
    • O43821
    • Q13720
    • Q3KPF1
    • Q8TDK9

    Protein attributes for FOXO4 Gene

    Size:
    505 amino acids
    Molecular mass:
    53684 Da
    Quaternary structure:
    • Interacts with CREBBP/CBP, CTNNB1, MYOCD, SIRT1, SRF and YWHAZ. Acetylated by CREBBP/CBP and deacetylated by SIRT1. Binding of YWHAZ inhibits DNA-binding. Interacts with USP7; the interaction is enhanced in presence of hydrogen peroxide and occurs independently of TP53. Interacts with NLK, and this inhibits monoubiquitination and transcriptional activity.

    Three dimensional structures from OCA and Proteopedia for FOXO4 Gene

    Alternative splice isoforms for FOXO4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXO4 Gene

Proteomics data for FOXO4 Gene at MOPED

Post-translational modifications for FOXO4 Gene

  • Acetylation by CREBBP/CBP, which is induced by peroxidase stress, inhibits transcriptional activity. Deacetylation by SIRT1 is NAD-dependent and stimulates transcriptional activity.
  • Monoubiquitinated; monoubiquitination is induced by oxidative stress and reduced by deacetylase inhibitors; results in its relocalization to the nucleus and its increased transcriptional activity. Deubiquitinated by USP7; deubiquitination is induced by oxidative stress; enhances its interaction with USP7 and consequently, deubiquitination; increases its translocation to the cytoplasm and inhibits its transcriptional activity. Hydrogene-peroxide-induced ubiquitination and USP7-mediated deubiquitination have no major effect on its protein stability.
  • Phosphorylation by PKB/AKT1 inhibits transcriptional activity and is responsible for cytoplasmic localization. May be phosphorylated at multiple sites by NLK.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXO4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FOXO4 (FOXO4)

No data available for DME Specific Peptides for FOXO4 Gene

Domains for FOXO4 Gene

Gene Families for FOXO4 Gene

HGNC:
  • FOX :Forkhead boxes

Protein Domains for FOXO4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FOXO4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P98177

UniProtKB/Swiss-Prot:

FOXO4_HUMAN :
  • P98177
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXO4: view

Function for FOXO4 Gene

Molecular function for FOXO4 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.

Gene Ontology (GO) - Molecular Function for FOXO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003677 DNA binding IDA 10783894
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 10783894
GO:0005515 protein binding IPI 15126506
GO:0008134 transcription factor binding IPI 16054032
genes like me logo Genes that share ontologies with FOXO4: view

Phenotypes for FOXO4 Gene

genes like me logo Genes that share phenotypes with FOXO4: view

Animal Models for FOXO4 Gene

MGI Knock Outs for FOXO4:

Animal Model Products

CRISPR Products

miRNA for FOXO4 Gene

miRTarBase miRNAs that target FOXO4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOXO4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FOXO4 Gene

Localization for FOXO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXO4 Gene

Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXO4 Gene COMPARTMENTS Subcellular localization image for FOXO4 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 2
extracellular 1

Gene Ontology (GO) - Cellular Components for FOXO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 22972301
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS 22972301
genes like me logo Genes that share ontologies with FOXO4: view

Pathways for FOXO4 Gene

genes like me logo Genes that share pathways with FOXO4: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for FOXO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IDA 15126506
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter TAS 10783894
GO:0007050 cell cycle arrest IDA 10783894
GO:0007095 mitotic G2 DNA damage checkpoint IEA --
genes like me logo Genes that share ontologies with FOXO4: view

Compounds for FOXO4 Gene

UniProtKB/Swiss-Prot:

P98177-FOXO4_HUMAN
Pharmaceutical: A constitutively active FOXO4 mutant where phosphorylation sites Thr-32, Ser-197 and Ser-262 have been mutated to alanine may have therapeutic potential in ERBB2/HER2-overexpressing cancers as it inhibits ERBB2-mediated cell survival, transformation and tumorigenicity

(1) HMDB Compounds for FOXO4 Gene

Compound Synonyms Cas Number PubMed IDs
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9

(3) Novoseek inferred chemical compound relationships for FOXO4 Gene

Compound -log(P) Hits PubMed IDs
wortmannin 51.9 2
phosphatidylinositol 50.8 1
glycogen 24 1
genes like me logo Genes that share compounds with FOXO4: view

Transcripts for FOXO4 Gene

Unigene Clusters for FOXO4 Gene

Forkhead box O4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOXO4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXO4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1: -
SP2: -
SP3:

Relevant External Links for FOXO4 Gene

GeneLoc Exon Structure for
FOXO4
ECgene alternative splicing isoforms for
FOXO4

Expression for FOXO4 Gene

mRNA expression in normal human tissues for FOXO4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for FOXO4 Gene

This gene is overexpressed in Fetal ovary (51.3), Placenta (8.9), and Fetal testis (8.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FOXO4 Gene

SOURCE GeneReport for Unigene cluster for FOXO4 Gene Hs.584654

mRNA Expression by UniProt/SwissProt for FOXO4 Gene

P98177-FOXO4_HUMAN
Tissue specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform zeta is most abundant in the liver, kidney, and pancreas
genes like me logo Genes that share expressions with FOXO4: view

Expression partners for FOXO4 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FOXO4 Gene

Orthologs for FOXO4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FOXO4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOXO4 35
  • 90.5 (n)
  • 89.11 (a)
FOXO4 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXO4 35
  • 91.02 (n)
  • 92.08 (a)
FOXO4 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxo4 35
  • 88.36 (n)
  • 88.69 (a)
Foxo4 16
Foxo4 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FOXO4 35
  • 97.77 (n)
  • 97.16 (a)
FOXO4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxo4 35
  • 88.36 (n)
  • 88.49 (a)
oppossum
(Monodelphis domestica)
Mammalia FOXO4 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOXO4 35
  • 60.19 (n)
  • 59.72 (a)
FOXO4 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXO4 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492831 35
  • 58.43 (n)
  • 59.82 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC563719 35
  • 58.46 (n)
  • 57.11 (a)
FOXO4 36
  • 37 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta foxo 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea daf-16 36
  • 24 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HCM1 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3143 36
  • 21 (a)
OneToMany
Species with no ortholog for FOXO4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FOXO4 Gene

ENSEMBL:
Gene Tree for FOXO4 (if available)
TreeFam:
Gene Tree for FOXO4 (if available)

Paralogs for FOXO4 Gene

Paralogs for FOXO4 Gene

Selected SIMAP similar genes for FOXO4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXO4: view

Variants for FOXO4 Gene

Sequence variations from dbSNP and Humsavar for FOXO4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1142823 -- 71,101,495(+) GGCTC(C/G)AGGCC reference, missense
rs4259556 -- 71,100,249(+) GGGCA(C/T)CCCCC intron-variant
rs4489469 -- 71,100,139(+) AGGAG(A/C)ACGTC intron-variant
rs4503258 -- 71,103,387(+) CTTTG(C/T)ATCGT utr-variant-3-prime
rs5936624 -- 71,094,283(+) AGAAA(A/G)AGAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FOXO4 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
esv33082 CNV Loss 17666407

Relevant External Links for FOXO4 Gene

HapMap Linkage Disequilibrium report
FOXO4
Locus Specific Mutation Databases (LSDB)
FOXO4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXO4 Gene

Disorders for FOXO4 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for FOXO4 Gene in MalaCards »

(3) Diseases for FOXO4 Gene including...

UniProtKB/Swiss-Prot

FOXO4_HUMAN
  • Note=A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X;11)(q13;q23) with KMT2A/MLL1. The result is a rogue activator protein.

(3) Novoseek inferred disease relationships for FOXO4 Gene

Disease -log(P) Hits PubMed IDs
acute leukemia 33.6 3
tumors 0 3
cancer 0 4

Relevant External Links for FOXO4

Genetic Association Database (GAD)
FOXO4
Human Genome Epidemiology (HuGE) Navigator
FOXO4
genes like me logo Genes that share disorders with FOXO4: view

No data available for OMIM and Genatlas for FOXO4 Gene

Publications for FOXO4 Gene

  1. Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23). (PMID: 9010221) Borkhardt A. … Lampert F. (Oncogene 1997) 3 4 23
  2. Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B. (PMID: 10518537) Takaishi H. … Nishizuka Y. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4 23
  3. Solution structure of the DNA binding domain of the human forkhead transcription factor AFX (FOXO4). (PMID: 11352721) Weigelt J. … Wikstrom M. (Biochemistry 2001) 3 4 23
  4. Constitutively active FOXO4 inhibits Akt activity, regulates p27 Kip1 stability, and suppresses HER2-mediated tumorigenicity. (PMID: 15688030) Yang H. … Lee M.-H. (Oncogene 2005) 3 4 23
  5. Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin. (PMID: 16054032) Liu Z.-P. … Olson E.N. (Dev. Cell 2005) 3 4 23

Products for FOXO4 Gene

  • Addgene plasmids for FOXO4

Sources for FOXO4 Gene

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