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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FOXO3 Gene

protein-coding   GIFtS: 61
GCID: GC06P108881

Forkhead Box O3


(Previous symbols: FKHRL1, FOXO3A)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Forkhead Box O31 2     FOXO22
FKHRL11 2 3 5     Forkhead Box O3A2
FOXO3A1 2 3 5     Forkhead Box Protein O32
Forkhead In Rhabdomyosarcoma-Like 12 3     Forkhead Homolog (Rhabdomyosarcoma) Like 12
AF6q212     Forkhead, Drosophila, Homolog Of, In Rhabdomyosarcoma-Like 12
FKHRL1P22     AF6q21 Protein3

External Ids:    HGNC: 38211   Entrez Gene: 23092   Ensembl: ENSG000001186897   OMIM: 6026815   UniProtKB: O435243   

Export aliases for FOXO3 gene to outside databases

Previous GC identifers: GC06P108988 GC06P106448


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FOXO3 Gene:
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead
domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell
death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively
spliced transcript variants encoding the same protein have been observed. (provided by RefSeq, Jul 2008)

GeneCards Summary for FOXO3 Gene: 
FOXO3 (forkhead box O3) is a protein-coding gene. Diseases associated with FOXO3 include rhabdomyosarcoma, and acute leukemia, and among its related super-pathways are Signal transduction AKT signaling and IL-9 Signaling Pathways. GO annotations related to this gene include protein kinase binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOXM1.

UniProtKB/Swiss-Prot: FOXO3_HUMAN, O43524
Function: Transcriptional activator which triggers apoptosis in the absence of survival factors, including
neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'.
Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction
of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC
transcript and prevent its translation

Gene Wiki entry for FOXO3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FOXO3 gene promoter:
         AP-1   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): FOXO3 promoter sequence
   Search SABiosciences Chromatin IP Primers for FOXO3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXO3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

FOXO3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXO3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P108881:  view genomic region     (about GC identifiers)

Start:
108,881,026 bp from pter      End:
109,005,977 bp from pter
Size:
124,952 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FOXO3_HUMAN, O43524 (See protein sequence)
Recommended Name: Forkhead box protein O3  
Size: 673 amino acids; 71277 Da
Subunit: Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta, which are required for cytosolic sequestration.
Upon oxidative stress, interacts with STK4/MST1, which disrupts interaction with YWHAB/14-3-3-beta and leads to
nuclear translocation. Interacts with PIM1. Interacts with DDIT3/CHOP
Subcellular location: Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus upon oxidative stress and in
the absence of survival factors
4 PDB 3D structures from and Proteopedia for FOXO3:
2K86 (3D)        2LQH (3D)        2LQI (3D)        2UZK (3D)    
Secondary accessions: E1P5E6 O15171 Q5T2I7 Q9BZ04

Explore the universe of human proteins at neXtProt for FOXO3: NX_O43524

Explore proteomics data for FOXO3 at MOPED 

Post-translational modifications:

  • UniProtKB: In the presence of survival factors such as IGF-1, phosphorylated on Thr-32 and Ser-253 by AKT1/PKB. This
    phosphorylated form then interacts with 14-3-3 proteins and is retained in the cytoplasm. Survival factor
    withdrawal induces dephosphorylation and promotes translocation to the nucleus where the dephosphorylated protein
    induces transcription of target genes and triggers apoptosis. Although AKT1/PKB doesn't appear to phosphorylate
    Ser-315 directly, it may activate other kinases that trigger phosphorylation at this residue. Phosphorylated by
    STK4/MST1 on Ser-209 upon oxidative stress, which leads to dissociation from YWHAB/14-3-3-beta and nuclear
    translocation. Phosphorylated by PIM1. Phosphorylation by AMPK leads to the activation of transcriptional
    activity without affecting subcellular localization. Phosphorylation by MAPKAPK5 promotes nuclear localization
    and DNA-binding, leading to induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC
    that bind to the 3'UTR of MYC transcript and prevent its translation
  • UniProtKB: Heavyly methylated by SET9 which decreases stability, while moderately increasing transcriptional activity. The
    main methylation site is Lys-271. Methylation doesn't affect subcellular location
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43524

  • FOXO3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FOXO3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001446.1  NP_963853.1  

    ENSEMBL proteins: 
     ENSP00000339527   ENSP00000385824   ENSP00000446316  
    Reactome Protein details: O43524
    Human Recombinant Protein Products for FOXO3: 
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for FOXO3
    OriGene Protein Over-expression Lysate for FOXO3
    OriGene MassSpec for FOXO3 
    OriGene Custom Protein Services for FOXO3
    GenScript Custom Purified and Recombinant Proteins Services for FOXO3
    Novus Biologicals FOXO3 Proteins
    Novus Biologicals FOXO3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FOXO3 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10102273
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex ----
    GO:0005737cytoplasm IDA10102273
    GO:0005829cytosol IBA--

    FOXO3 for ontologies           About GeneDecksing



    FOXO3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of FOXO3
    R&D Systems Antibodies for FOXO3
    Cell Signaling Technology (CST) Antibodies for FOXO3  (FOXO3A)
    OriGene Antibodies for FOXO3
    OriGene Custom Antibody Services for FOXO3
    GenScript Custom Superior Antibodies Services for FOXO3
    Novus Biologicals FOXO3 Antibodies
    Abcam antibodies for FOXO3
    Cloud-Clone Corp. Antibodies for FOXO3 
    ThermoFisher Antibody for FOXO3
    LSBio Antibodies in human, mouse, rat for FOXO3 

    Assay Products for FOXO3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FOXO3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FOXO3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FOXO3 
    Cloud-Clone Corp. CLIAs for FOXO3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FOX: Forkhead boxes

    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry O43524

    ProtoNet protein and cluster: O43524

    UniProtKB/Swiss-Prot: FOXO3_HUMAN, O43524
    Similarity: Contains 1 fork-head DNA-binding domain


    FOXO3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOXO3_HUMAN, O43524
    Function: Transcriptional activator which triggers apoptosis in the absence of survival factors, including
    neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'.
    Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction
    of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC
    transcript and prevent its translation

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA--
    GO:0003690double-stranded DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IDA14734530
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity ----
    GO:0005515protein binding IPI14976264
         
    FOXO3 for ontologies           About GeneDecksing


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Foxo3):
     cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  renal/urinary system 
     reproductive system  respiratory system  tumorigenesis 

    FOXO3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FOXO3: Foxo3tm1Nmt Foxo3tm1.1Rdp

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FOXO3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FOXO3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FOXO3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FOXO3 

    10/357 SABiosciences Target genes for FOXO3 (see all 357):
    ABCD4 ABRA ACAD10 ACOXL ACTG2 ADAMTS15 AFAP1L1 AFM AGBL4 AKAP14

    miRNA
    Products:
        
    miRTarBase miRNAs that target FOXO3:
    hsa-mir-221 (MIRT000434), hsa-mir-182 (MIRT000671), hsa-mir-197 (MIRT004198), hsa-mir-222 (MIRT000433), hsa-mir-155 (MIRT004495), hsa-mir-96 (MIRT005450)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOXO3
    8/134 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXO3 (see all 134):
    hsa-miR-579 hsa-miR-520f hsa-miR-1245 hsa-miR-3074-3p hsa-miR-138-2* hsa-miR-3916 hsa-miR-520b hsa-miR-186*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FOXO3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXO3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FOXO3
    Sirion Biotech Customized adenovirus for overexpression of FOXO3

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for FOXO3 (see all 14)
    OriGene ORF clones in mouse, rat for FOXO3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FOXO3 (NM_001455)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXO3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXO3
    Sirion Biotech Customized lentivirus for stable overexpression of FOXO3 
                         Customized lentivirus expression plasmids for stable overexpression of FOXO3 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for FOXO3
    Search LifeMap BioReagents cell lines for FOXO3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXO3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FOXO3 About   (see all 50)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development IGF-RI signaling
    Development IGF-RI signaling0.49
    Development IGF-1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    2Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
    IL-9 Signaling Pathways0.90
    IL-15 Signaling Pathways0.88
    IL-7 Signaling Pathways0.90
    IL-2 Signaling Pathways0.88
    IL-21 Signaling Pathways0.90
    IL-4 Signaling Pathways0.84
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    IL-7 Signaling Pathway0.40
    3Glioma
    Non-small cell lung cancer0.51
    Signaling Pathways in Glioblastoma0.36
    4Endometrial cancer
    Endometrial cancer0.45
    Signal transduction PTEN pathway0.45
    5Signaling by FGFR
    Downstream signaling of activated FGFR0.92
    Downstream signal transduction0.90
    Signaling by FGFR0.92
    Signaling by PDGF0.85
    Signaling by FGFR in disease0.91
    Signaling by EGFR0.84
    DAP12 signaling0.91
    Signaling by EGFR in Cancer0.83

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for FOXO3
        Signal transduction PTEN pathway
    Signal transduction AKT signaling
    Translation Non-genomic (rapid) action of Androgen Receptor
    Development IGF-RI signaling

    5/9 R&D Systems Pathways for FOXO3 (see all 9)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Akt Signaling Pathway
    IL-7 Signaling Pathways

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FOXO3 (see all 9)
        ErbB2-ErbB3 Heterodimers
    14-3-3 Induced Apoptosis
    IGF1R Signaling
    PI3K Signaling in B-Lymphocyte
    ERK5 Signaling

    2 Cell Signaling Technology (CST) Pathways for FOXO3
        MAP Kinase Signaling
    PI3K / Akt Signaling

    4 GeneGo (Thomson Reuters) Pathways for FOXO3
        Signal transduction AKT signaling
    Signal transduction PTEN pathway
    Development IGF-1 receptor signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    5/21 BioSystems Pathways for FOXO3 (see all 21)
        DNA damage response (only ATM dependent)
    Insulin Signaling
    Spinal Cord Injury
    Signaling Pathways in Glioblastoma
    BDNF signaling pathway

    5/34        Reactome Pathways for FOXO3 (see all 34)
        Signaling by EGFR in Cancer
    Downstream signal transduction
    Signal Transduction
    Signaling by PDGF
    Downstream Signaling Events Of B Cell Receptor (BCR)


    5/6         Kegg Pathways  (Kegg details for FOXO3) (see all 6):
        Chemokine signaling pathway
    PI3K-Akt signaling pathway
    Neurotrophin signaling pathway
    Prolactin signaling pathway
    Endometrial cancer


    FOXO3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FOXO3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/352 Interacting proteins for FOXO3 (O435241, 2, 3 ENSP000003395274) via UniProtKB, MINT, STRING, and/or I2D (see all 352)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 5/29 biological process terms (GO ID links to tree view) (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP18787191
    GO:0001542ovulation from ovarian follicle IEA--
    GO:0001544initiation of primordial ovarian follicle growth IEA--
    GO:0001547antral ovarian follicle growth IEA--
    GO:0001556oocyte maturation IEA--

    FOXO3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FOXO3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FOXO3

    10/20 Novoseek inferred chemical compound relationships for FOXO3 gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol 70.8 11 19911116 (1), 14701673 (1), 15207915 (1), 16687394 (1) (see all 9)
    ly294002 67.6 10 11694570 (1), 19911116 (1), 10944433 (1), 14656735 (1) (see all 9)
    phosphoinositide 52.3 8 19302476 (1), 12150827 (1), 12504093 (1), 20484037 (1) (see all 6)
    imatinib 48.7 17 17900262 (5), 15509806 (3), 17132628 (2), 15277706 (1) (see all 6)
    wortmannin 43.3 1 18385518 (1)
    glycogen 36.4 6 18476967 (1), 11237865 (1), 17522055 (1), 12139625 (1) (see all 5)
    tyrosine 29.7 6 17900262 (2), 19285077 (1), 12456669 (1), 12506011 (1)
    rapamycin 24.5 2 18476967 (1), 12782577 (1)
    threonine 15.2 1 12359217 (1)
    l-nmma 8.07 5 17044646 (3)

    Search CenterWatch for drugs/clinical trials and news about FOXO3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FOXO3 gene (2 alternative transcripts): 
    NM_001455.3  NM_201559.2  

    Unigene Cluster for FOXO3:

    Forkhead box O3
    Hs.220950  [show with all ESTs]
    Unigene Representative Sequence: NM_001455
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343882(uc003psk.2 uc011ean.1 uc010kdj.1) ENST00000406360(uc003psm.2)
    ENST00000540898

    miRNA
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    8/134 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXO3 (see all 134):
    hsa-miR-579 hsa-miR-520f hsa-miR-1245 hsa-miR-3074-3p hsa-miR-138-2* hsa-miR-3916 hsa-miR-520b hsa-miR-186*
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXO3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXO3
    Sirion Biotech Customized lentivirus for stable overexpression of FOXO3 
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXO3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXO3

    Additional mRNA sequence: 

    AB072905.1 AF032886.1 AJ001589.1 AK024103.1 AK092357.1 AK122861.1 AK301304.1 AK303933.1 
    AK311587.1 BC020227.1 BC021224.2 BC045800.1 BC068552.1 CR749261.1 

    19 DOTS entries:

    DT.100649722  DT.95294944  DT.100755530  DT.216108  DT.121004366  DT.100649556  DT.101981892  DT.97771444 
    DT.100823907  DT.100755532  DT.100726911  DT.95200828  DT.95354316  DT.121313784  DT.91901643  DT.95162771 
    DT.100702119  DT.91746714  DT.99940058 

    24/142 AceView cDNA sequences (see all 142):

    AF032886 AA603521 NM_201559 BX503867 CF541001 N21159 BX390986 BC068552 
    AA602472 CR623727 BM683563 BQ214507 NM_001455 AI919238 AA197198 AA453067 
    AV704145 BX106027 BF222626 AW001951 AA465236 AI031844 BQ636125 AI630797 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FOXO3 expression in normal human tissues (normalized intensities)      FOXO3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATAAAGC
    FOXO3 Expression
    About this image


    FOXO3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Uterus (Reproductive System)    fully expand to see all 5 entries
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Ovary (Reproductive System)    fully expand to see all 4 entries
             Primary Oocyte Primordial Follicle
             ovary ; follicle cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             urinary bladder ; urothelial cells   
             visceral organ   

    See FOXO3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FOXO3

    SOURCE GeneReport for Unigene cluster: Hs.220950

    UniProtKB/Swiss-Prot: FOXO3_HUMAN, O43524
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Arrays including FOXO3 (see all 6): 
              Leukemia in human mouse rat
              p53 Signaling Pathway in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FOXO3 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Foxo31 , 5 forkhead box O31, 5 90.38(n)1
    94.79(a)1
      10 (22.79 cM)5
    564841  NM_019740.21  NP_062714.11 
     421818415 
    chicken
    (Gallus gallus)
    Aves FOXO31 forkhead box O3 80.11(n)
    88.74(a)
      421769  XM_001234495.2  XP_001234496.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.20742 Xenopus laevis transcribed sequences 84.27(n)    BJ070632.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF114262.12   -- 77.12(n)   30296  AF114262.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta foxo1 forkhead box, sub-group O 51.3(n)
    46.79(a)
      41709  NM_206483.2  NP_996205.1 
    worm
    (Caenorhabditis elegans)
    Secernentea daf-166
    fkh-106
    Protein FKH-10
    27(a)
    24(a)
    1 ↔ many
    possible ortholog
    I(10750343-10776700)
    I(10163475-10165135)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HCM16
    Forkhead transcription factor that drives S-phase ...
    14(a)
    1 → many
    III(229310-231004)


    ENSEMBL Gene Tree for FOXO3 (if available)
    TreeFam Gene Tree for FOXO3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FOXO3 gene
    FOXM12  FOXO62  FOXO42  FOXO12  
    4 SIMAP similar genes for FOXO3 using alignment to 2 protein entries:     FOXO3_HUMAN (see all proteins):
    DKFZp781A0677    FKHRL1P2    FOXO1    FOXO4

    FOXO3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FOXO3
    PGOHUM00000236954


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2172 SNPs in FOXO3 are shown (see all 2172)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs119690271,2
    C,A,H--108879051(+) GCCTAA/GCTGTC 1 -- us2k10--------
    rs117523881,2
    C,H--108879588(+) CTCGAT/ATGTTT 1 -- us2k1 tfbs35Minor allele frequency- A:0.00NS EA NA 414
    rs1455623621,2
    C--108879829(+) GGGCGA/CTGCGC 1 -- us2k10--------
    rs1472922991,2
    --108879905(+) TGTATC/GGGGTC 1 -- us2k10--------
    rs802312431,2
    --108880013(+) GCATGC/TCGCGT 1 -- us2k10--------
    rs283969611,2
    C--108880104(+) ACCTAA/GAGGAT 2 -- us2k11Minor allele frequency- G:0.00NA 2
    rs744476711,2
    C,F--108880154(+) TTTGTC/TGTCAT 2 -- us2k13Minor allele frequency- T:0.05NA 124
    rs1827335671,2
    --108880262(+) TACACC/TTCTCC 2 -- us2k10--------
    rs1497948531,2
    --108880444(+) CTGCCC/TATCTT 2 -- us2k10--------
    rs729406661,2
    C,F--108880487(+) TGTCGC/TGTTCT 2 -- us2k12Minor allele frequency- T:0.05WA EA 238

    HapMap Linkage Disequilibrium report for FOXO3 (108881026 - 109005977 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FOXO3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2651848CNV Deletion19546169
    nsv5433CNV Insertion18451855
    esv22566CNV Loss19812545
    nsv823817CNV Gain20364138
    nsv830767CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602681    OMIM disorders: --

    UniProtKB/Swiss-Prot: FOXO3_HUMAN, O43524
  • Note=A chromosomal aberration involving FOXO3 is found in secondary acute leukemias. Translocation
    t(6;11)(q21;q23) with KMT2A/MLL1

  • 20/56 diseases for FOXO3 (see all 56):    About MalaCards
    rhabdomyosarcoma    acute leukemia    balanitis    amenorrhea
    differentiating neuroblastoma    lymphedema    premature ovarian failure    lipodystrophy
    anaplastic large cell lymphoma    leukemia    neuroblastoma    microphthalmia
    cleft lip    myeloid leukemia    prostate cancer, progression of    scleroderma
    muscular atrophy    prostate cancer    narcolepsy    lupus erythematosus


    FOXO3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/12 Novoseek inferred disease relationships for FOXO3 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rhabdomyosarcoma 36.1 1 12196101 (1)
    breast cancer 33.2 30 20371610 (4), 18312651 (4), 17575143 (4), 14527951 (3) (see all 12)
    prostate cancer 32.2 11 12351634 (3), 17522055 (2), 15798096 (2), 17563745 (1) (see all 5)
    tumors 31.3 28 15551757 (3), 15084260 (2), 19564415 (2), 18312651 (2) (see all 14)
    cancer 29 10 19564415 (2), 20484037 (2), 19911116 (1), 18239069 (1) (see all 8)
    leukemia 24.7 2 11278373 (1), 18055337 (1)
    myeloid leukemia chronic 17 4 17900262 (1), 12456669 (1), 18644865 (1)
    necrosis 6.84 4 17900262 (1), 18166693 (1), 19473970 (1), 15322085 (1)
    lupus erythematosus systemic 0 2 17873969 (1), 18045156 (1)
    neovascularization 0 1 16100571 (1)

    Genetic Association Database (GAD): FOXO3
    Human Genome Epidemiology (HuGE) Navigator: FOXO3 (3 documents)

    Export disorders for FOXO3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FOXO3 gene, integrated from 9 sources (see all 395):
    (articles sorted by number of sources associating them with FOXO3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. (PubMed id 9479491)1, 2, 3, 9 Anderson M.J.... Arden K.C. (1998)
    2. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). (PubMed id 11154281)1, 2, 9 Brunet A.... Greenberg M.E. (2001)
    3. Association of FOXO3A variation with human longevity confirmed in German centenarians. (PubMed id 19196970)1, 4, 9 Flachsbart F....Nebel A. (2009)
    4. Polymorphisms in FOXO gene family and association analysis with BMI. (PubMed id 16571842)1, 4, 9 Kim J.R....Shin H.D. (2006)
    5. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. (PubMed id 10102273)1, 2, 9 Brunet A.... Greenberg M.E. (1999)
    6. Methylation by Set9 modulates FoxO3 stability and transcriptional activity. (PubMed id 22820736)1, 2 Calnan D.R.... Brunet A. (2012)
    7. A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3. (PubMed id 21216879)1, 4 Kaplan R.C....Wallaschofski H. (2011)
    8. Association of the FOXO3A locus with extreme longevity in a southern italian centenarian study. (PubMed id 19415983)1, 4 Anselmi C.V....Puca A.A. (2009)
    9. Genetic association of FOXO1A and FOXO3A with longevi ty trait in Han Chinese populations. (PubMed id 19793722)1, 4 Li Y....Tian X.L. (2009)
    10. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2309 HGNC: 3821 AceView: FOXO3A Ensembl:ENSG00000118689 euGenes: HUgn2309
    ECgene: FOXO3 Kegg: 2309 H-InvDB: FOXO3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FOXO3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FOXO3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FOXO3 gene:
    Search GeneIP for patents involving FOXO3

    Licensable Technologies for FOXO3 gene:
     Salk Institute: Increasing Life Span by Modulation of the Smek Gene
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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