Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FOXO3 Gene

protein-coding   GIFtS: 60
GCID: GC06P108881

Forkhead Box O3


(Previous symbols: FKHRL1, FOXO3A)
  See FOXO3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Forkhead Box O31 2     FOXO22
FKHRL11 2 3 5     Forkhead Box O3A2
FOXO3A1 2 3 5     Forkhead Box Protein O32
Forkhead In Rhabdomyosarcoma-Like 12 3     Forkhead Homolog (Rhabdomyosarcoma) Like 12
AF6q212     Forkhead, Drosophila, Homolog Of, In Rhabdomyosarcoma-Like 12
FKHRL1P22     AF6q21 Protein3

External Ids:    HGNC: 38211   Entrez Gene: 23092   Ensembl: ENSG000001186897   OMIM: 6026815   UniProtKB: O435243   

Export aliases for FOXO3 gene to outside databases

Previous GC identifers: GC06P108988 GC06P106448


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FOXO3 Gene:
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead
domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell
death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively
spliced transcript variants encoding the same protein have been observed. (provided by RefSeq, Jul 2008)

GeneCards Summary for FOXO3 Gene:
FOXO3 (forkhead box O3) is a protein-coding gene. Diseases associated with FOXO3 include rhabdomyosarcoma, and acute leukemia. GO annotations related to this gene include protein kinase binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOXM1.

UniProtKB/Swiss-Prot: FOXO3_HUMAN, O43524
Function: Transcriptional activator which triggers apoptosis in the absence of survival factors, including
neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'.
Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction
of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC
transcript and prevent its translation

Gene Wiki entry for FOXO3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FOXO3 gene promoter:
         AP-1   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): FOXO3 promoter sequence
   Search Chromatin IP Primers for FOXO3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FOXO3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

FOXO3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXO3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P108881:  view genomic region     (about GC identifiers)

Start:
108,881,026 bp from pter      End:
109,005,977 bp from pter
Size:
124,952 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FOXO3_HUMAN, O43524 (See protein sequence)
Recommended Name: Forkhead box protein O3  
Size: 673 amino acids; 71277 Da
Subunit: Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta, which are required for cytosolic sequestration.
Upon oxidative stress, interacts with STK4/MST1, which disrupts interaction with YWHAB/14-3-3-beta and leads to
nuclear translocation. Interacts with PIM1. Interacts with DDIT3/CHOP
4 PDB 3D structures from and Proteopedia for FOXO3:
2K86 (3D)        2LQH (3D)        2LQI (3D)        2UZK (3D)    
Secondary accessions: E1P5E6 O15171 Q5T2I7 Q9BZ04

Explore the universe of human proteins at neXtProt for FOXO3: NX_O43524

Explore proteomics data for FOXO3 at MOPED

Post-translational modifications: 

  • In the presence of survival factors such as IGF-1, phosphorylated on Thr-32 and Ser-253 by AKT1/PKB. This
    phosphorylated form then interacts with 14-3-3 proteins and is retained in the cytoplasm. Survival factor
    withdrawal induces dephosphorylation and promotes translocation to the nucleus where the dephosphorylated protein
    induces transcription of target genes and triggers apoptosis. Although AKT1/PKB doesn't appear to phosphorylate
    Ser-315 directly, it may activate other kinases that trigger phosphorylation at this residue. Phosphorylated by
    STK4/MST1 on Ser-209 upon oxidative stress, which leads to dissociation from YWHAB/14-3-3-beta and nuclear
    translocation. Phosphorylated by PIM1. Phosphorylation by AMPK leads to the activation of transcriptional
    activity without affecting subcellular localization. Phosphorylation by MAPKAPK5 promotes nuclear localization
    and DNA-binding, leading to induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC
    that bind to the 3'UTR of MYC transcript and prevent its translation1
  • Heavyly methylated by SET9 which decreases stability, while moderately increasing transcriptional activity. The
    main methylation site is Lys-271. Methylation doesn't affect subcellular location1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FOXO3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001446.1  NP_963853.1  

    ENSEMBL proteins: 
     ENSP00000339527   ENSP00000385824   ENSP00000446316  
    Reactome Protein details: O43524

    FOXO3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for FOXO3
    OriGene Protein Over-expression Lysate for FOXO3
    OriGene MassSpec for FOXO3
    OriGene Custom Protein Services for FOXO3
    GenScript Custom Purified and Recombinant Proteins Services for FOXO3
    Novus Biologicals FOXO3 Proteins
    Novus Biologicals FOXO3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FOXO3

     
    Search eBioscience for Proteins for FOXO3 

     
    antibodies-online proteins for FOXO3 (6 products) 

     
    antibodies-online peptides for FOXO3

    FOXO3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FOXO3
    R&D Systems Antibodies for FOXO3
    Cell Signaling Technology (CST) Antibodies for FOXO3  (FOXO3A)
    OriGene Antibodies for FOXO3
    OriGene Custom Antibody Services for FOXO3
    Novus Biologicals FOXO3 Antibodies
    Abcam antibodies for FOXO3
    Cloud-Clone Corp. Antibodies for FOXO3
    ThermoFisher Antibody for FOXO3
    antibodies-online antibodies for FOXO3 (214 products) 

    FOXO3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FOXO3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FOXO3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FOXO3
    Cloud-Clone Corp. CLIAs for FOXO3
    Search eBioscience for ELISAs for FOXO3 
    antibodies-online kits for FOXO3 (22 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    FOX: Forkhead boxes

    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry O43524

    ProtoNet protein and cluster: O43524

    UniProtKB/Swiss-Prot: FOXO3_HUMAN, O43524
    Similarity: Contains 1 fork-head DNA-binding domain


    Find genes that share domains with FOXO3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOXO3_HUMAN, O43524
    Function: Transcriptional activator which triggers apoptosis in the absence of survival factors, including
    neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'.
    Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction
    of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC
    transcript and prevent its translation

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA--
    GO:0003700sequence-specific DNA binding transcription factor activity IDA14734530
    GO:0005515protein binding IPI14976264
    GO:0008301DNA binding, bending IBA--
    GO:0019901protein kinase binding IPI16751106
         
    Find genes that share ontologies with FOXO3           About GenesLikeMe


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Foxo3):
     cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  renal/urinary system 
     reproductive system  respiratory system  tumorigenesis 

    Find genes that share phenotypes with FOXO3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FOXO3: Foxo3tm1Nmt Foxo3tm1.1Rdp

       genOway: Develop your customized and physiologically relevant rodent model for FOXO3

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for FOXO3 (see all 337):
    ABCD4,  ABRA,  ACAD10,  ACOXL,  ACTG2,  ADAMTS15,  AFAP1L1,  AFM,  AKAP14,  ALKBH6

    miRNA
    Products:
        
    miRTarBase miRNAs that target FOXO3:
    hsa-mir-744-5p (MIRT037525), hsa-mir-23a-3p (MIRT006284), hsa-mir-197-3p (MIRT004198), hsa-mir-155-5p (MIRT004495), hsa-mir-26a-5p (MIRT050180), hsa-mir-221-3p (MIRT000434), hsa-mir-335-5p (MIRT017201), hsa-mir-182-5p (MIRT000671), hsa-let-7c-5p (MIRT051735), hsa-mir-222-3p (MIRT000433), hsa-mir-615-3p (MIRT039975), hsa-mir-96-5p (MIRT005450), hsa-mir-9-5p (MIRT007326)

    Block miRNA regulation of human, mouse, rat FOXO3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FOXO3 (see all 134):
    hsa-miR-579 hsa-miR-520f hsa-miR-1245 hsa-miR-3074-3p hsa-miR-138-2* hsa-miR-3916 hsa-miR-520b hsa-miR-186*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FOXO3
    Predesigned siRNA for gene silencing in human, mouse, rat FOXO3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FOXO3

    Clone
    Products:
         
    OriGene clones in human, mouse for FOXO3 (see all 12)
    OriGene ORF clones in mouse, rat for FOXO3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FOXO3 (NM_001455)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXO3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXO3
    Addgene plasmids for FOXO3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FOXO3
    Browse ESI BIO Cell Lines and PureStem Progenitors for FOXO3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXO3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FOXO3_HUMAN, O43524: Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus upon oxidative stress and in
    the absence of survival factors
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    lysosome1
    mitochondrion1
    vacuole1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10102273
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA10102273
    GO:0005829cytosol IBA--
    GO:0016020membrane IEA--

    Find genes that share ontologies with FOXO3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FOXO3 About   (see all 49)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    2IL-9 Signaling Pathways
    IL-9 Signaling Pathways0.90
    IL-2 Signaling Pathways0.88
    IL-7 Signaling Pathways0.90
    IL-15 Signaling Pathways0.88
    IL-21 Signaling Pathways0.90
    IL-4 Signaling Pathways0.84
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    IL-7 Signaling Pathway0.40
    3Glioma
    Non-small cell lung cancer0.51
    Signaling Pathways in Glioblastoma0.36
    4Endometrial cancer
    Endometrial cancer0.45
    Signal transduction PTEN pathway0.45
    5PI-3K cascade
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    GAB1 signalosome0.93
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Signaling by SCF-KIT0.72
    PIP3 activates AKT signaling0.88
    Signaling by ERBB40.66


    Find genes that share SuperPaths with FOXO3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for FOXO3 (see all 9)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Akt Signaling Pathway
    IL-7 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FOXO3 (see all 9)
        ErbB2-ErbB3 Heterodimers
    14-3-3 Induced Apoptosis
    IGF1R Signaling
    PI3K Signaling in B-Lymphocyte
    ERK5 Signaling

    2 Cell Signaling Technology (CST) Pathways for FOXO3
        MAP Kinase Signaling
    PI3K / Akt Signaling

    4 GeneGo (Thomson Reuters) Pathways for FOXO3
        Signal transduction AKT signaling
    Signal transduction PTEN pathway
    Development IGF-1 receptor signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    Selected BioSystems Pathways for FOXO3 (see all 21)
        Insulin Signaling
    DNA damage response (only ATM dependent)
    BDNF signaling pathway
    Spinal Cord Injury
    Signaling Pathways in Glioblastoma

    3 Reactome Pathways for FOXO3
        AKT phosphorylates targets in the nucleus
    Constitutive PI3K/AKT Signaling in Cancer
    Signaling by NODAL


    Selected Kegg Pathways  (Kegg details for FOXO3) (see all 7):
        Chemokine signaling pathway
    FoxO signaling pathway
    PI3K-Akt signaling pathway
    Neurotrophin signaling pathway
    Prolactin signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FOXO3 (see all 6): 
              Leukemia in human mouse rat
              p53 Signaling Pathway in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FOXO3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FOXO3 (O435241, 2, 3 ENSP000003395274) via UniProtKB, MINT, STRING, and/or I2D (see all 372)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP18787191
    GO:0001542ovulation from ovarian follicle IEA--
    GO:0001544initiation of primordial ovarian follicle growth IEA--
    GO:0001547antral ovarian follicle growth IEA--
    GO:0001556oocyte maturation IEA--

    Find genes that share ontologies with FOXO3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FOXO3

    Selected Novoseek inferred chemical compound relationships for FOXO3 gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol 70.8 11 19911116 (1), 14701673 (1), 15207915 (1), 16687394 (1) (see all 9)
    ly294002 67.6 10 11694570 (1), 19911116 (1), 10944433 (1), 14656735 (1) (see all 9)
    phosphoinositide 52.3 8 19302476 (1), 12150827 (1), 12504093 (1), 20484037 (1) (see all 6)
    imatinib 48.7 17 17900262 (5), 15509806 (3), 17132628 (2), 15277706 (1) (see all 6)
    wortmannin 43.3 1 18385518 (1)
    glycogen 36.4 6 18476967 (1), 11237865 (1), 17522055 (1), 12139625 (1) (see all 5)
    tyrosine 29.7 6 17900262 (2), 19285077 (1), 12456669 (1), 12506011 (1)
    rapamycin 24.5 2 18476967 (1), 12782577 (1)
    threonine 15.2 1 12359217 (1)
    l-nmma 8.07 5 17044646 (3)



    Find genes that share compounds with FOXO3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FOXO3 gene (2 alternative transcripts): 
    NM_001455.3  NM_201559.2  

    Unigene Cluster for FOXO3:

    Forkhead box O3
    Hs.220950  [show with all ESTs]
    Unigene Representative Sequence: NM_001455
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343882(uc003psk.2 uc011ean.1 uc010kdj.1) ENST00000406360(uc003psm.2)
    ENST00000540898
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FOXO3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FOXO3 (see all 134):
    hsa-miR-579 hsa-miR-520f hsa-miR-1245 hsa-miR-3074-3p hsa-miR-138-2* hsa-miR-3916 hsa-miR-520b hsa-miR-186*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FOXO3
    Predesigned siRNA for gene silencing in human, mouse, rat FOXO3
    Clone
    Products:
         
    OriGene clones in human, mouse for FOXO3 (see all 12)
    OriGene ORF clones in mouse, rat for FOXO3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FOXO3 (NM_001455)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXO3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXO3
    Addgene plasmids for FOXO3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FOXO3
    OriGene qSTAR qPCR primer pairs in human, mouse for FOXO3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FOXO3
      QuantiTect SYBR Green Assays in human, mouse, rat FOXO3
      QuantiFast Probe-based Assays in human, mouse, rat FOXO3

    Additional mRNA sequence: 

    AB072905.1 AF032886.1 AJ001589.1 AK024103.1 AK092357.1 AK122861.1 AK301304.1 AK303933.1 
    AK311587.1 BC020227.1 BC021224.2 BC045800.1 BC068552.1 CR749261.1 

    19 DOTS entries:

    DT.100649722  DT.95294944  DT.100755530  DT.216108  DT.121004366  DT.100649556  DT.101981892  DT.97771444 
    DT.100823907  DT.100755532  DT.100726911  DT.95200828  DT.95354316  DT.121313784  DT.91901643  DT.95162771 
    DT.100702119  DT.91746714  DT.99940058 

    Selected AceView cDNA sequences (see all 142):

    AA465236 CR623727 AV704145 AA603521 AA602472 BC020227 AI031844 AK122861 
    CA389775 AI919238 BX106027 NM_201559 AA453067 BG057950 N29118 BM718517 
    BE502772 AI358905 AI554317 BC021224 AI075785 AI521727 BX503867 BQ214507 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FOXO3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATAAAGC
    FOXO3 Expression
    About this image


    FOXO3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Proerythroblasts Hematopoietic Bone Marrow
             Umbilical cord blood-derived hematopoietic stem cells
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord blood-derived hematopoietic stem cells
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Thymus (Hematopoietic System)
             Thymus
    FOXO3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FOXO3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.220950

    UniProtKB/Swiss-Prot: FOXO3_HUMAN, O43524
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FOXO3 (see all 6): 
              Leukemia in human mouse rat
              p53 Signaling Pathway in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FOXO3
    OriGene qSTAR qPCR primer pairs in human, mouse for FOXO3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FOXO3
    QuantiTect SYBR Green Assays in human, mouse, rat FOXO3
    QuantiFast Probe-based Assays in human, mouse, rat FOXO3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXO3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FOXO3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Foxo31 , 5 forkhead box O31, 5 89.68(n)1
    93.9(a)1
      10 (22.79 cM)5
    564841  NM_019740.21  NP_062714.11 
     421818415 
    chicken
    (Gallus gallus)
    Aves FOXO31 forkhead box O3 79.24(n)
    87.62(a)
      421769  XM_001234495.3  XP_001234496.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.20742 Xenopus laevis transcribed sequences 84.27(n)    BJ070632.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF114262.12   -- 77.12(n)   30296  AF114262.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta foxo6
    forkhead box, sub-group O
    32(a)
    1 → many
    3R(9882690-9913700)
    worm
    (Caenorhabditis elegans)
    Secernentea daf-166
    Protein DAF-16, isoform h
    28(a)
    1 → many
    I(10750343-10776700) WBGene00000912
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HCM16
    Forkhead transcription factor that drives S-phase ...
    15(a)
    1 → many
    III(229310-231004) YCR065W


    ENSEMBL Gene Tree for FOXO3 (if available)
    TreeFam Gene Tree for FOXO3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FOXO3 gene
    FOXM12  FOXO62  FOXO42  FOXO12  
    4 SIMAP similar genes for FOXO3 using alignment to 2 protein entries:     FOXO3_HUMAN (see all proteins):
    DKFZp781A0677    FKHRL1P2    FOXO1    FOXO4

    Find genes that share paralogs with FOXO3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for FOXO3
    PGOHUM00000236954


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FOXO3 (see all 2172)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs119690271,2
    C,A,H--108879051(+) GCCTAA/GCTGTC 1 -- us2k10--------
    rs117523881,2
    C,H--108879588(+) CTCGAT/ATGTTT 1 -- us2k1 tfbs35Minor allele frequency- A:0.00NS EA NA 414
    rs1455623621,2
    C--108879829(+) GGGCGA/CTGCGC 1 -- us2k10--------
    rs1472922991,2
    --108879905(+) TGTATC/GGGGTC 1 -- us2k10--------
    rs802312431,2
    --108880013(+) GCATGC/TCGCGT 1 -- us2k10--------
    rs283969611,2
    C--108880104(+) ACCTAA/GAGGAT 2 -- us2k11Minor allele frequency- G:0.00NA 2
    rs744476711,2
    C,F--108880154(+) TTTGTC/TGTCAT 2 -- us2k13Minor allele frequency- T:0.05NA 124
    rs1827335671,2
    --108880262(+) TACACC/TTCTCC 2 -- us2k10--------
    rs1497948531,2
    --108880444(+) CTGCCC/TATCTT 2 -- us2k10--------
    rs729406661,2
    C,F--108880487(+) TGTCGC/TGTTCT 2 -- us2k12Minor allele frequency- T:0.05WA EA 238

    HapMap Linkage Disequilibrium report for FOXO3 (108881026 - 109005977 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FOXO3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2651848CNV Deletion19546169
    nsv5433CNV Insertion18451855
    esv22566CNV Loss19812545
    nsv823817CNV Gain20364138
    nsv830767CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FOXO3
    DNA2.0 Custom Variant and Variant Library Synthesis for FOXO3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602681    OMIM disorders: --

    UniProtKB/Swiss-Prot: FOXO3_HUMAN, O43524
  • Note=A chromosomal aberration involving FOXO3 is found in secondary acute leukemias. Translocation
    t(6;11)(q21;q23) with KMT2A/MLL1

  • 3 diseases for FOXO3:    
    About MalaCards
    rhabdomyosarcoma    acute leukemia    neuroblastoma


    Find genes that share disorders with FOXO3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for FOXO3 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rhabdomyosarcoma 36.1 1 12196101 (1)
    breast cancer 33.2 30 20371610 (4), 18312651 (4), 17575143 (4), 14527951 (3) (see all 12)
    prostate cancer 32.2 11 12351634 (3), 17522055 (2), 15798096 (2), 17563745 (1) (see all 5)
    tumors 31.3 28 15551757 (3), 15084260 (2), 19564415 (2), 18312651 (2) (see all 14)
    cancer 29 10 19564415 (2), 20484037 (2), 19911116 (1), 18239069 (1) (see all 8)
    leukemia 24.7 2 11278373 (1), 18055337 (1)
    myeloid leukemia chronic 17 4 17900262 (1), 12456669 (1), 18644865 (1)
    necrosis 6.84 4 17900262 (1), 18166693 (1), 19473970 (1), 15322085 (1)
    lupus erythematosus systemic 0 2 17873969 (1), 18045156 (1)
    neovascularization 0 1 16100571 (1)

    Genetic Association Database (GAD): FOXO3
    Human Genome Epidemiology (HuGE) Navigator: FOXO3 (3 documents)

    Export disorders for FOXO3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FOXO3 gene, integrated from 10 sources (see all 411):
    (articles sorted by number of sources associating them with FOXO3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. (PubMed id 9479491)1, 2, 3, 9 Anderson M.J.... Arden K.C. (Genomics 1998)
    2. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). (PubMed id 11154281)1, 2, 9 Brunet A.... Greenberg M.E. (Mol. Cell. Biol. 2001)
    3. Association of FOXO3A variation with human longevity confirmed in German centenarians. (PubMed id 19196970)1, 4, 9 Flachsbart F....Nebel A. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    4. Polymorphisms in FOXO gene family and association analysis with BMI. (PubMed id 16571842)1, 4, 9 Kim J.R....Shin H.D. (Obesity (Silver Spring) 2006)
    5. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. (PubMed id 10102273)1, 2, 9 Brunet A.... Greenberg M.E. (Cell 1999)
    6. Methylation by Set9 modulates FoxO3 stability and transcriptional activity. (PubMed id 22820736)1, 2 Calnan D.R.... Brunet A. (Aging (Albany NY) 2012)
    7. A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3. (PubMed id 21216879)1, 4 Kaplan R.C....Wallaschofski H. (Hum. Mol. Genet. 2011)
    8. Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study. (PubMed id 19415983)1, 4 Anselmi C.V....Puca A.A. (Rejuvenation Res 2009)
    9. Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. (PubMed id 19793722)1, 4 Li Y....Tian X.L. (Hum. Mol. Genet. 2009)
    10. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PubMed id 19010793)1, 4 Baranzini S.E....Oksenberg J.R. (Hum. Mol. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2309 HGNC: 3821 AceView: FOXO3A Ensembl:ENSG00000118689 euGenes: HUgn2309
    ECgene: FOXO3 Kegg: 2309 H-InvDB: FOXO3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FOXO3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FOXO3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FOXO3 gene:
    Search GeneIP for patents involving FOXO3

    Licensable Technologies for FOXO3 gene:
     Salk Institute: Increasing Life Span by Modulation of the Smek Gene
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of FOXO3
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for FOXO3 (FoxO3)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for FOXO3   OriGene RNAi products in human, mouse, rat for FOXO3  
     OriGene qPCR primer pairs and template standards for FOXO3   OriGene Protein Over-expression Lysate for FOXO3  
     OriGene MassSpec for FOXO3   OriGene clones in human, mouse for FOXO3  
     OriGene qSTAR qPCR primer pairs in human, mouse for FOXO3   OriGene Purified Protein for FOXO3  
     OriGene ORF clones in mouse, rat for FOXO3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FOXO3   OriGene Custom Protein Services for FOXO3  

     
     
     Block miRNA regulation of human, mouse, rat FOXO3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FOXO3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FOXO3 Predesigned siRNA for gene silencing in human, mouse, rat FOXO3
     QuantiFast Probe-based Assays in human, mouse, rat FOXO3 QuantiTect SYBR Green Assays in human, mouse, rat FOXO3
     PCR Arrays including human, mouse, rat FOXO3 Search Chromatin IP Primers for FOXO3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FOXO3  GeneGlobe Interaction Network for FOXO3
     Regulatory tfbs in FOXO3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for FOXO3 GenScript cDNA clones with any tag delivered in your preferred vector for FOXO3
     GenScript Custom Assay Services for FOXO3 GenScript Custom overexpressing Cell Line Services for FOXO3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for FOXO3  (FOXO3A)

     Search Tocris compounds for FOXO3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FOXO3 antibodies
     FOXO3 proteins
     FOXO3 lysates
     Antibodies for FOXO3
     See all of Abcam's Antibodies, Kits and Proteins for FOXO3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for FOXO3
     Antibodies for FOXO3
     ELISAs for FOXO3
     CLIAs for FOXO3



     Browse ESI BIO Cell Lines and PureStem Progenitors for FOXO3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXO3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for FOXO3
     SwitchGear Promoter luciferase reporter plasmids for FOXO3
     ThermoFisher Antibody for FOXO3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXO3
     Browse compounds at ApexBio
     Addgene plasmids for FOXO3
      Search eBioscience for proteins for FOXO3
      Search eBioscience for elisas for FOXO3
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for FOXO3
     antibodies-online antibodies for FOXO3 (214 products)
     antibodies-online kits for FOXO3 (22 products)
     antibodies-online peptides for FOXO3
     antibodies-online proteins for FOXO3 (6 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FOXO3 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4