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Aliases for FOXO1 Gene

Aliases for FOXO1 Gene

  • Forkhead Box O1 2 3 5
  • Forkhead Box Protein O1A 3 4
  • FOXO1A 3 4
  • FKHR 3 4
  • Forkhead, Drosophila, Homolog Of, In Rhabdomyosarcoma 3
  • Forkhead Homolog In Rhabdomyosarcoma 2
  • Forkhead In Rhabdomyosarcoma 4
  • FKH1 3

External Ids for FOXO1 Gene

Previous HGNC Symbols for FOXO1 Gene

  • FKHR
  • FOXO1A

Previous GeneCards Identifiers for FOXO1 Gene

  • GC13M040028
  • GC13M041129
  • GC13M021931

Summaries for FOXO1 Gene

Entrez Gene Summary for FOXO1 Gene

  • This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXO1 Gene

FOXO1 (Forkhead Box O1) is a Protein Coding gene. Diseases associated with FOXO1 include Rhabdomyosarcoma 2, Alveolar and Rhabdomyosarcoma. Among its related pathways are Constitutive Signaling by AKT1 E17K in Cancer and IL-7 Signaling Pathways. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is FOXO4.

UniProtKB/Swiss-Prot for FOXO1 Gene

  • Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5-TT[G/A]TTTTG-3 and the related Daf-16 family binding element (DBE) with consensus sequence 5-TT[G/A]TTTAC-3. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.

Gene Wiki entry for FOXO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXO1 Gene

Genomics for FOXO1 Gene

Regulatory Elements for FOXO1 Gene

Enhancers for FOXO1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FOXO1 on UCSC Golden Path with GeneCards custom track

Promoters for FOXO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FOXO1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FOXO1 Gene

Chromosome:
13
Start:
40,555,664 bp from pter
End:
40,666,660 bp from pter
Size:
110,997 bases
Orientation:
Minus strand

Genomic View for FOXO1 Gene

Genes around FOXO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXO1 Gene

Proteins for FOXO1 Gene

  • Protein details for FOXO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12778-FOXO1_HUMAN
    Recommended name:
    Forkhead box protein O1
    Protein Accession:
    Q12778
    Secondary Accessions:
    • O43523
    • Q5VYC7
    • Q6NSK6

    Protein attributes for FOXO1 Gene

    Size:
    655 amino acids
    Molecular mass:
    69662 Da
    Quaternary structure:
    • Interacts with LRPPRC. Interacts with RUNX2; the interaction inhibits RUNX2 transcriptional activity and mediates the IGF1/insulin-dependent BGLAP expression in osteoblasts Interacts with PPP2R1A; the interaction regulates the dephosphorylation of FOXO1 at Thr-24 and Ser-256 leading to its nuclear import. Interacts (acetylated form) with PPARG. Interacts with XBP1 isoform 2; this interaction is direct and leads to FOXO1 ubiquitination and degradation via the proteasome pathway (By similarity). Interacts with NLK. Interacts with SIRT1; the interaction results in the deacetylation of FOXO1 leading to activation of FOXO1-mediated transcription of genes involved in DNA repair and stress resistance. Binds to CDK1. Interacts with the 14-3-3 proteins, YWHAG and YWHAZ; the interactions require insulin-stimulated phosphorylation on Thr-24, promote nuclear exit and loss of transcriptional activity. Interacts with SKP2; the interaction ubiquitinates FOXO1 leading to its proteosomal degradation. The interaction requires the presence of KRIT1. Interacts (via the C-terminal half) with ATF4 (via its DNA-binding domain); the interaction occurs in osteoblasts, regulates glucose homeostasis via suppression of beta-cell proliferation and subsequent decrease in insulin production. Interacts with PRMT1; the interaction methylates FOXO1, prevents PKB/AKT1 phosphorylation and retains FOXO1 in the nucleus. Interacts with EP300 and CREBBP; the interactions acetylate FOXO1. Interacts with SIRT2; the interaction is disrupted in response to oxidative stress or serum deprivation, leading to increased level of acetylated FOXO1, which promotes stress-induced autophagy by stimulating E1-like activating enzyme ATG7. Interacts (acetylated form) with ATG7; the interaction is increased in response to oxidative stress or serum deprivation and promotes the autophagic process leading to cell death. Interacts (via the Fork-head domain) with CEBPA; the interaction increases when FOXO1 is deacetylated. Interacts with WDFY2. Forms a complex with WDFY2 and AKT1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for FOXO1 Gene

neXtProt entry for FOXO1 Gene

Proteomics data for FOXO1 Gene at MOPED

Post-translational modifications for FOXO1 Gene

  • Acetylated. Acetylation at Lys-262, Lys-265 and Lys-274 are necessary for autophagic cell death induction. Deacetylated by SIRT2 in response to oxidative stress or serum deprivation, thereby negatively regulating FOXO1-mediated autophagic cell death.
  • Methylation inhibits AKT1-mediated phosphorylation at Ser-256 and is increased by oxidative stress.
  • Once in the nucleus, acetylated by CREBBP/EP300. Acetylation diminishes the interaction with target DNA and attenuates the transcriptional activity. It increases the phosphorylation at Ser-256. Deacetylation by SIRT1 results in reactivation of the transcriptional activity. Oxidative stress by hydrogen peroxide treatment appears to promote deacetylation and uncoupling of insulin-induced phosphorylation. By contrast, resveratrol acts independently of acetylation.
  • Phosphorylation by NLK promotes nuclear export and inhibits the transcriptional activity. In response to growth factors, phosphorylation on Thr-24, Ser-256 and Ser-322 by PKB/AKT1 promotes nuclear export and inactivation of transactivational activity. Phosphorylation on Thr-24 is required for binding 14-3-3 proteins. Phosphorylation of Ser-256 decreases DNA-binding activity and promotes the phosphorylation of Thr-24 and Ser-319, permitting phosphorylation of Ser-322 and Ser-325, probably by CDK1, leading to nuclear exclusion and loss of function. Stress signals, such as response to oxygen or nitric oxide, attenuate the PKB/AKT1-mediated phosphorylation leading to nuclear retention. Phosphorylation of Ser-329 is independent of IGF1 and leads to reduced function. Dephosphorylated on Thr-24 and Ser-256 by PP2A in beta-cells under oxidative stress leading to nuclear retention (By similarity). Phosphorylation of Ser-249 by CDK1 disrupts binding of 14-3-3 proteins leading to nuclear accumulation and has no effect on DNA-binding nor transcriptional activity. Phosphorylation by STK4/MST1 on Ser-212, upon oxidative stress, inhibits binding to 14-3-3 proteins and nuclear export.
  • Ubiquitinated by SRT2. Ubiquitination leads to proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXO1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXO1 Gene

Domains & Families for FOXO1 Gene

Gene Families for FOXO1 Gene

Protein Domains for FOXO1 Gene

Suggested Antigen Peptide Sequences for FOXO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12778

UniProtKB/Swiss-Prot:

FOXO1_HUMAN :
  • Contains 1 fork-head DNA-binding domain.
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXO1: view

Function for FOXO1 Gene

Molecular function for FOXO1 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5-TT[G/A]TTTTG-3 and the related Daf-16 family binding element (DBE) with consensus sequence 5-TT[G/A]TTTAC-3. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.
UniProtKB/Swiss-Prot Induction:
Expression is regulated by KRIT1. Levels of expression also regulated by FOXC1 which binds to a conserved element in the FOXO1 promoter.

Gene Ontology (GO) - Molecular Function for FOXO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001223 transcription coactivator binding IEA --
GO:0005515 protein binding IEA,IPI 11237865
GO:0008013 beta-catenin binding IDA 15905404
GO:0008134 transcription factor binding IEA --
genes like me logo Genes that share ontologies with FOXO1: view
genes like me logo Genes that share phenotypes with FOXO1: view

Human Phenotype Ontology for FOXO1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FOXO1 Gene

MGI Knock Outs for FOXO1:

Animal Model Products

CRISPR Products

miRNA for FOXO1 Gene

miRTarBase miRNAs that target FOXO1

Transcription Factor Targets for FOXO1 Gene

Selected GeneGlobe predicted Target genes for FOXO1
Targeted motifs for FOXO1 Gene
HOMER Transcription Factor Regulatory Elements motif FOXO1
  • Consensus sequence: CTGTTTAC Submotif: canonical Cell Type: RAW

No data available for Enzyme Numbers (IUBMB) for FOXO1 Gene

Localization for FOXO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXO1 Gene

Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and nucleus. Largely nuclear in unstimulated cells. In osteoblasts, colocalizes with ATF4 and RUNX2 in the nucleus (By similarity). Insulin-induced phosphorylation at Ser-256 by PKB/AKT1 leads, via stimulation of Thr-24 phosphorylation, to binding of 14-3-3 proteins and nuclear export to the cytoplasm where it is degraded by the ubiquitin-proteosomal pathway. Phosphorylation at Ser-249 by CDK1 disrupts binding of 14-3-3 proteins and promotes nuclear accumulation. Phosphorylation by NLK results in nuclear export. Translocates to the nucleus upon oxidative stress-induced phosphorylation at Ser-212 by STK4/MST1. SGK1-mediated phosphorylation also results in nuclear translocation. Retained in the nucleus under stress stimuli including oxidative stress, nutrient deprivation or nitric oxide. Retained in the nucleus on methylation. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXO1 Gene COMPARTMENTS Subcellular localization image for FOXO1 gene
Compartment Confidence
cytosol 5
mitochondrion 5
nucleus 5
cytoskeleton 2
extracellular 2
peroxisome 2
plasma membrane 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for FOXO1 Gene

Pathways & Interactions for FOXO1 Gene

SuperPathways for FOXO1 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 IL-7 Signaling Pathways
3 PI3K events in ERBB4 signaling
4 Constitutive Signaling by AKT1 E17K in Cancer
5 Immune response IL-23 signaling pathway
genes like me logo Genes that share pathways with FOXO1: view

SIGNOR curated interactions for FOXO1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FOXO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001568 blood vessel development IEA --
GO:0001678 cellular glucose homeostasis ISS 22510882
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with FOXO1: view

Drugs & Compounds for FOXO1 Gene

(12) Drugs for FOXO1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(9) Additional Compounds for FOXO1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FOXO1: view

Transcripts for FOXO1 Gene

Unigene Clusters for FOXO1 Gene

Forkhead box O1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXO1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6
SP1: - - -
SP2: -
SP3: - -
SP4: -

Relevant External Links for FOXO1 Gene

GeneLoc Exon Structure for
FOXO1
ECgene alternative splicing isoforms for
FOXO1

Expression for FOXO1 Gene

mRNA expression in normal human tissues for FOXO1 Gene

mRNA differential expression in normal tissues according to GTEx for FOXO1 Gene

This gene is overexpressed in Muscle - Skeletal (x7.4).

Protein differential expression in normal tissues from HIPED for FOXO1 Gene

This gene is overexpressed in Blymphocyte (20.0), CD4 Tcells (19.0), CD8 Tcells (12.0), and Peripheral blood mononuclear cells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FOXO1 Gene



SOURCE GeneReport for Unigene cluster for FOXO1 Gene Hs.370666

mRNA Expression by UniProt/SwissProt for FOXO1 Gene

Q12778-FOXO1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with FOXO1: view

Protein tissue co-expression partners for FOXO1 Gene

- Elite partner

Primer Products

Orthologs for FOXO1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FOXO1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOXO1 35
  • 90.22 (n)
  • 95.46 (a)
FOXO1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXO1 35
  • 92.62 (n)
  • 95.11 (a)
FOXO1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxo1 35
  • 89.21 (n)
  • 92.91 (a)
Foxo1 16
Foxo1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FOXO1 35
  • 99.75 (n)
  • 100 (a)
FOXO1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxo1 35
  • 88.85 (n)
  • 92.76 (a)
oppossum
(Monodelphis domestica)
Mammalia FOXO1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOXO1 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOXO1 35
  • 77.85 (n)
  • 77.48 (a)
FKHR 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXO1 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia foxo1 35
  • 72.43 (n)
  • 72.32 (a)
Str.14625 35
zebrafish
(Danio rerio)
Actinopterygii foxo1a 35
  • 64.67 (n)
  • 63.95 (a)
FOXO1 (3 of 3) 36
  • 73 (a)
OneToMany
foxo1a 36
  • 55 (a)
OneToMany
foxo1b 36
  • 54 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta foxo 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea daf-16 36
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HCM1 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3143 36
  • 25 (a)
OneToMany
Species with no ortholog for FOXO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FOXO1 Gene

ENSEMBL:
Gene Tree for FOXO1 (if available)
TreeFam:
Gene Tree for FOXO1 (if available)

Paralogs for FOXO1 Gene

Paralogs for FOXO1 Gene

(3) SIMAP similar genes for FOXO1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for FOXO1 Gene

genes like me logo Genes that share paralogs with FOXO1: view

Variants for FOXO1 Gene

Sequence variations from dbSNP and Humsavar for FOXO1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1078892 -- 40,563,883(-) GCTGC(A/G)TTCCA intron-variant, upstream-variant-2KB
rs1413482 -- 40,644,314(-) GAGGA(A/G)GAGTC intron-variant
rs1334241 -- 40,648,973(-) TTCCC(A/G)CAGAC intron-variant
rs1360719 -- 40,651,737(-) ATAAT(C/G)TTATA intron-variant
rs1801100 -- 40,617,006(+) ACCCG(A/C/G/T)CCTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOXO1 Gene

Variant ID Type Subtype PubMed ID
nsv525547 CNV Loss 19592680
esv2747290 CNV Deletion 23290073

Variation tolerance for FOXO1 Gene

Residual Variation Intolerance Score: 16.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.86; 58.87% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FOXO1 Gene

Disorders for FOXO1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for FOXO1 Gene - From: OMIM, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
rhabdomyosarcoma 2, alveolar
  • rhabdomyosarcoma, alveolar
rhabdomyosarcoma
muscle cancer
  • malignant neoplasm of muscle, nos
skeletal muscle cancer
  • malignant tumor of skeletal muscle
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search FOXO1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FOXO1_HUMAN
  • Rhabdomyosarcoma 2 (RMS2) [MIM:268220]: A form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchymal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. Note=The gene represented in this entry may be involved in disease pathogenesis. Chromosomal aberrations involving FOXO1 are found in rhabdomyosarcoma. Translocation (2;13)(q35;q14) with PAX3 and translocation t(1;13)(p36;q14) with PAX7. The resulting protein is a transcriptional activator.

Relevant External Links for FOXO1

Genetic Association Database (GAD)
FOXO1
Human Genome Epidemiology (HuGE) Navigator
FOXO1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXO1
genes like me logo Genes that share disorders with FOXO1: view

No data available for Genatlas for FOXO1 Gene

Publications for FOXO1 Gene

  1. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 2 3 4 67
  2. Green tea polyphenol epigallocatechin gallate reduces endothelin-1 expression and secretion in vascular endothelial cells: roles for AMP-activated protein kinase, Akt, and FOXO1. (PMID: 19887561) Reiter C.E. … Quon M.J. (Endocrinology 2010) 3 23
  3. Regulation of FOXO1 by TAK1-Nemo-like kinase pathway. (PMID: 20061393) Kim S. … Chung J. (J. Biol. Chem. 2010) 3 23
  4. Advanced glycation end-products affect transcription factors regulating insulin gene expression. (PMID: 20353756) Puddu A. … Viviani G.L. (Biochem. Biophys. Res. Commun. 2010) 3 23
  5. Association of common genetic variation in the FOXO1 gene with beta-cell dysfunction, impaired glucose tolerance, and type 2 diabetes. (PMID: 19141580) MA1ssig K. … HAoring H.U. (J. Clin. Endocrinol. Metab. 2009) 3 23

Products for FOXO1 Gene

Sources for FOXO1 Gene

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