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Aliases for FOXO1 Gene

Aliases for FOXO1 Gene

  • Forkhead Box O1 2 3 5
  • Forkhead Box Protein O1A 3 4
  • FOXO1A 3 4
  • FKHR 3 4
  • Forkhead, Drosophila, Homolog Of, In Rhabdomyosarcoma 3
  • Forkhead Homolog In Rhabdomyosarcoma 2
  • Forkhead In Rhabdomyosarcoma 4
  • Forkhead Box Protein O1 3
  • FKH1 3

External Ids for FOXO1 Gene

Previous HGNC Symbols for FOXO1 Gene

  • FKHR
  • FOXO1A

Previous GeneCards Identifiers for FOXO1 Gene

  • GC13M040028
  • GC13M041129
  • GC13M021931

Summaries for FOXO1 Gene

Entrez Gene Summary for FOXO1 Gene

  • This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXO1 Gene

FOXO1 (Forkhead Box O1) is a Protein Coding gene. Diseases associated with FOXO1 include Rhabdomyosarcoma 2, Alveolar and Rhabdomyosarcoma. Among its related pathways are Regulation of nuclear SMAD2/3 signaling and CXCR4-mediated signaling events. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is FOXO3.

UniProtKB/Swiss-Prot for FOXO1 Gene

  • Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5-TT[G/A]TTTTG-3 and the related Daf-16 family binding element (DBE) with consensus sequence 5-TT[G/A]TTTAC-3. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.

Gene Wiki entry for FOXO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXO1 Gene

Genomics for FOXO1 Gene

Regulatory Elements for FOXO1 Gene

Enhancers for FOXO1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F040475 1.6 FANTOM5 Ensembl ENCODE 10.9 +187.8 187827 5.9 HDGF PKNOX1 MLX ARID4B DMAP1 ZNF48 YY1 SP5 MXD4 MIER2 FOXO1 GC13P040478 GC13P040487
GH13F040561 1.3 Ensembl ENCODE 11.7 +99.8 99846 10.0 PKNOX1 ATF1 MLX ARID4B DMAP1 ZNF48 ZNF121 ZNF766 FOS PPARG FOXO1 SLC25A15 WBP4 CYCSP34 GC13P040543 RLIMP1
GH13F040444 1.3 Ensembl ENCODE 11.2 +220.8 220838 2.4 HDGF PKNOX1 ATF1 ARNT CREB3L1 SIN3A YBX1 ZNF2 YY1 CBX5 FOXO1 GC13P040478 RN7SKP2
GH13F040770 1.2 ENCODE 11 -104.4 -104437 1.9 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 SSRP1 LINC00548 MORF4L1P4 ELF1 FOXO1 KBTBD6 SLC25A15 MRPS31 ENSG00000277794
GH13F040584 1.1 Ensembl ENCODE 11.8 +78.3 78289 7.3 PKNOX1 TBL1XR1 ARID4B BMI1 RAD21 CBX5 ETV6 JUNB TBX21 SMARCA4 TPTE2P5 FOXO1 SLC25A15 WBP4 RLIMP1 GC13P040543
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FOXO1 on UCSC Golden Path with GeneCards custom track

Promoters for FOXO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000514866 1360 5401 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF48 ZNF2 ZNF121 GLIS2 CBX5

Genomic Location for FOXO1 Gene

Chromosome:
13
Start:
40,469,953 bp from pter
End:
40,666,660 bp from pter
Size:
196,708 bases
Orientation:
Minus strand

Genomic View for FOXO1 Gene

Genes around FOXO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXO1 Gene

Proteins for FOXO1 Gene

  • Protein details for FOXO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12778-FOXO1_HUMAN
    Recommended name:
    Forkhead box protein O1
    Protein Accession:
    Q12778
    Secondary Accessions:
    • O43523
    • Q5VYC7
    • Q6NSK6

    Protein attributes for FOXO1 Gene

    Size:
    655 amino acids
    Molecular mass:
    69662 Da
    Quaternary structure:
    • Interacts with LRPPRC. Interacts with RUNX2; the interaction inhibits RUNX2 transcriptional activity and mediates the IGF1/insulin-dependent BGLAP expression in osteoblasts Interacts with PPP2R1A; the interaction regulates the dephosphorylation of FOXO1 at Thr-24 and Ser-256 leading to its nuclear import. Interacts (acetylated form) with PPARG. Interacts with XBP1 isoform 2; this interaction is direct and leads to FOXO1 ubiquitination and degradation via the proteasome pathway (By similarity). Interacts with NLK. Interacts with SIRT1; the interaction results in the deacetylation of FOXO1 leading to activation of FOXO1-mediated transcription of genes involved in DNA repair and stress resistance. Binds to CDK1. Interacts with the 14-3-3 proteins, YWHAG and YWHAZ; the interactions require insulin-stimulated phosphorylation on Thr-24, promote nuclear exit and loss of transcriptional activity. Interacts with SKP2; the interaction ubiquitinates FOXO1 leading to its proteosomal degradation. The interaction requires the presence of KRIT1. Interacts (via the C-terminal half) with ATF4 (via its DNA-binding domain); the interaction occurs in osteoblasts, regulates glucose homeostasis via suppression of beta-cell proliferation and subsequent decrease in insulin production. Interacts with PRMT1; the interaction methylates FOXO1, prevents PKB/AKT1 phosphorylation and retains FOXO1 in the nucleus. Interacts with EP300 and CREBBP; the interactions acetylate FOXO1. Interacts with SIRT2; the interaction is disrupted in response to oxidative stress or serum deprivation, leading to increased level of acetylated FOXO1, which promotes stress-induced autophagy by stimulating E1-like activating enzyme ATG7. Interacts (acetylated form) with ATG7; the interaction is increased in response to oxidative stress or serum deprivation and promotes the autophagic process leading to cell death. Interacts (via the Fork-head domain) with CEBPA; the interaction increases when FOXO1 is deacetylated. Interacts with WDFY2. Forms a complex with WDFY2 and AKT1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for FOXO1 Gene

neXtProt entry for FOXO1 Gene

Post-translational modifications for FOXO1 Gene

  • Acetylated. Acetylation at Lys-262, Lys-265 and Lys-274 are necessary for autophagic cell death induction. Deacetylated by SIRT2 in response to oxidative stress or serum deprivation, thereby negatively regulating FOXO1-mediated autophagic cell death.
  • Methylation inhibits AKT1-mediated phosphorylation at Ser-256 and is increased by oxidative stress.
  • Once in the nucleus, acetylated by CREBBP/EP300. Acetylation diminishes the interaction with target DNA and attenuates the transcriptional activity. It increases the phosphorylation at Ser-256. Deacetylation by SIRT1 results in reactivation of the transcriptional activity. Oxidative stress by hydrogen peroxide treatment appears to promote deacetylation and uncoupling of insulin-induced phosphorylation. By contrast, resveratrol acts independently of acetylation.
  • Phosphorylation by NLK promotes nuclear export and inhibits the transcriptional activity. In response to growth factors, phosphorylation on Thr-24, Ser-256 and Ser-322 by PKB/AKT1 promotes nuclear export and inactivation of transactivational activity. Phosphorylation on Thr-24 is required for binding 14-3-3 proteins. Phosphorylation of Ser-256 decreases DNA-binding activity and promotes the phosphorylation of Thr-24 and Ser-319, permitting phosphorylation of Ser-322 and Ser-325, probably by CDK1, leading to nuclear exclusion and loss of function. Stress signals, such as response to oxygen or nitric oxide, attenuate the PKB/AKT1-mediated phosphorylation leading to nuclear retention. Phosphorylation of Ser-329 is independent of IGF1 and leads to reduced function. Dephosphorylated on Thr-24 and Ser-256 by PP2A in beta-cells under oxidative stress leading to nuclear retention (By similarity). Phosphorylation of Ser-249 by CDK1 disrupts binding of 14-3-3 proteins leading to nuclear accumulation and has no effect on DNA-binding nor transcriptional activity. Phosphorylation by STK4/MST1 on Ser-212, upon oxidative stress, inhibits binding to 14-3-3 proteins and nuclear export.
  • Ubiquitinated by SRT2. Ubiquitination leads to proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXO1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FOXO1 (FOXO1A)
  • Cloud-Clone Corp. Antibodies for FOXO1

No data available for DME Specific Peptides for FOXO1 Gene

Domains & Families for FOXO1 Gene

Gene Families for FOXO1 Gene

Protein Domains for FOXO1 Gene

Suggested Antigen Peptide Sequences for FOXO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12778

UniProtKB/Swiss-Prot:

FOXO1_HUMAN :
  • Contains 1 fork-head DNA-binding domain.
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXO1: view

Function for FOXO1 Gene

Molecular function for FOXO1 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5-TT[G/A]TTTTG-3 and the related Daf-16 family binding element (DBE) with consensus sequence 5-TT[G/A]TTTAC-3. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.
UniProtKB/Swiss-Prot Induction:
Expression is regulated by KRIT1. Levels of expression also regulated by FOXC1 which binds to a conserved element in the FOXO1 promoter.

Gene Ontology (GO) - Molecular Function for FOXO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0000989 transcription factor activity, transcription factor binding IEA --
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0001223 transcription coactivator binding IEA --
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
genes like me logo Genes that share ontologies with FOXO1: view
genes like me logo Genes that share phenotypes with FOXO1: view

Human Phenotype Ontology for FOXO1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FOXO1 Gene

MGI Knock Outs for FOXO1:

Animal Model Products

miRNA for FOXO1 Gene

miRTarBase miRNAs that target FOXO1

Transcription Factor Targets for FOXO1 Gene

Selected GeneGlobe predicted Target genes for FOXO1
Targeted motifs for FOXO1 Gene
HOMER Transcription Factor Regulatory Elements motif FOXO1
  • Consensus sequence: CTGTTTAC Submotif: canonical Cell Type: RAW

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FOXO1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) for FOXO1 Gene

Localization for FOXO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXO1 Gene

Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and nucleus. Largely nuclear in unstimulated cells. In osteoblasts, colocalizes with ATF4 and RUNX2 in the nucleus (By similarity). Insulin-induced phosphorylation at Ser-256 by PKB/AKT1 leads, via stimulation of Thr-24 phosphorylation, to binding of 14-3-3 proteins and nuclear export to the cytoplasm where it is degraded by the ubiquitin-proteosomal pathway. Phosphorylation at Ser-249 by CDK1 disrupts binding of 14-3-3 proteins and promotes nuclear accumulation. Phosphorylation by NLK results in nuclear export. Translocates to the nucleus upon oxidative stress-induced phosphorylation at Ser-212 by STK4/MST1. SGK1-mediated phosphorylation also results in nuclear translocation. Retained in the nucleus under stress stimuli including oxidative stress, nutrient deprivation or nitric oxide. Retained in the nucleus on methylation. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXO1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
cytoskeleton 2
peroxisome 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FOXO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 11311120
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 11237865
GO:0005739 mitochondrion ISS 22510882
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FOXO1: view

Pathways & Interactions for FOXO1 Gene

genes like me logo Genes that share pathways with FOXO1: view

SIGNOR curated interactions for FOXO1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FOXO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001568 blood vessel development IEA --
GO:0001659 temperature homeostasis ISS 22510882
GO:0001678 cellular glucose homeostasis ISS 22510882
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with FOXO1: view

Drugs & Compounds for FOXO1 Gene

(13) Drugs for FOXO1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(8) Additional Compounds for FOXO1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FOXO1: view

Transcripts for FOXO1 Gene

Unigene Clusters for FOXO1 Gene

Forkhead box O1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FOXO1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXO1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6
SP1: - - -
SP2: -
SP3: - -
SP4: -

Relevant External Links for FOXO1 Gene

GeneLoc Exon Structure for
FOXO1
ECgene alternative splicing isoforms for
FOXO1

Expression for FOXO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FOXO1 Gene

mRNA differential expression in normal tissues according to GTEx for FOXO1 Gene

This gene is overexpressed in Muscle - Skeletal (x7.4).

Protein differential expression in normal tissues from HIPED for FOXO1 Gene

This gene is overexpressed in Blymphocyte (20.0), CD4 Tcells (19.0), CD8 Tcells (12.0), and Peripheral blood mononuclear cells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FOXO1 Gene



Protein tissue co-expression partners for FOXO1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FOXO1 Gene:

FOXO1

SOURCE GeneReport for Unigene cluster for FOXO1 Gene:

Hs.370666

mRNA Expression by UniProt/SwissProt for FOXO1 Gene:

Q12778-FOXO1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with FOXO1: view

Primer Products

Orthologs for FOXO1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FOXO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXO1 34 35
  • 99.75 (n)
dog
(Canis familiaris)
Mammalia FOXO1 34 35
  • 92.62 (n)
cow
(Bos Taurus)
Mammalia FOXO1 34 35
  • 90.22 (n)
mouse
(Mus musculus)
Mammalia Foxo1 34 16 35
  • 89.21 (n)
rat
(Rattus norvegicus)
Mammalia Foxo1 34
  • 88.85 (n)
oppossum
(Monodelphis domestica)
Mammalia FOXO1 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOXO1 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves FKHR 35
  • 80 (a)
OneToOne
FOXO1 34
  • 77.85 (n)
lizard
(Anolis carolinensis)
Reptilia FOXO1 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia foxo1 34
  • 72.43 (n)
Str.14625 34
zebrafish
(Danio rerio)
Actinopterygii FOXO1 (3 of 3) 35
  • 73 (a)
OneToMany
foxo1a 34 35
  • 64.67 (n)
foxo1b 35
  • 54 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta foxo 35
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea daf-16 35
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HCM1 35
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3143 35
  • 25 (a)
OneToMany
Species where no ortholog for FOXO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FOXO1 Gene

ENSEMBL:
Gene Tree for FOXO1 (if available)
TreeFam:
Gene Tree for FOXO1 (if available)

Paralogs for FOXO1 Gene

Paralogs for FOXO1 Gene

(3) SIMAP similar genes for FOXO1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for FOXO1 Gene

genes like me logo Genes that share paralogs with FOXO1: view

Variants for FOXO1 Gene

Sequence variations from dbSNP and Humsavar for FOXO1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs10162172 -- 40,625,560(+) AATCC(A/G)TTATT intron-variant
rs10507484 -- 40,643,997(-) AGTAA(A/G)TATTA intron-variant
rs10507485 -- 40,640,403(-) CGATA(C/T)TTAGA intron-variant
rs10507486 -- 40,612,364(-) ATCTT(C/T)GTAGC intron-variant
rs10552634 -- 40,624,339(+) AAAAA(-/A)GATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOXO1 Gene

Variant ID Type Subtype PubMed ID
nsv525547 CNV loss 19592680
esv3892332 CNV gain 25118596
esv3352453 CNV duplication 20981092
esv2747290 CNV deletion 23290073

Variation tolerance for FOXO1 Gene

Residual Variation Intolerance Score: 16.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.86; 58.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXO1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXO1 Gene

Disorders for FOXO1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for FOXO1 Gene - From: OMIM, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
rhabdomyosarcoma 2, alveolar
  • rhabdomyosarcoma, alveolar
rhabdomyosarcoma
muscle cancer
  • malignant neoplasm of muscle, nos
skeletal muscle cancer
  • malignant tumor of skeletal muscle
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search FOXO1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FOXO1_HUMAN
  • Rhabdomyosarcoma 2 (RMS2) [MIM:268220]: A form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchymal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. Note=The gene represented in this entry may be involved in disease pathogenesis. Chromosomal aberrations involving FOXO1 are found in rhabdomyosarcoma. Translocation (2;13)(q35;q14) with PAX3 and translocation t(1;13)(p36;q14) with PAX7. The resulting protein is a transcriptional activator.

Relevant External Links for FOXO1

Genetic Association Database (GAD)
FOXO1
Human Genome Epidemiology (HuGE) Navigator
FOXO1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXO1
genes like me logo Genes that share disorders with FOXO1: view

No data available for Genatlas for FOXO1 Gene

Publications for FOXO1 Gene

  1. Association of common genetic variation in the FOXO1 gene with beta-cell dysfunction, impaired glucose tolerance, and type 2 diabetes. (PMID: 19141580) MA1ssig K. … HAoring H.U. (J. Clin. Endocrinol. Metab. 2009) 3 22 46 64
  2. Structural basis for DNA recognition by FoxO1 and its regulation by posttranslational modification. (PMID: 18786403) Brent M.M. … Marmorstein R. (Structure 2008) 3 4 22 64
  3. Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt. (PMID: 18951090) Yamagata K. … Fukamizu A. (Mol. Cell 2008) 3 4 22 64
  4. Analysis of FOXO1A as a candidate gene for type 2 diabetes. (PMID: 16497530) Karim M.A. … Elbein S.C. (Mol. Genet. Metab. 2006) 3 22 46 64
  5. The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription. (PMID: 15890677) Perrot V. … Rechler M.M. (Mol. Endocrinol. 2005) 3 4 22 64

Products for FOXO1 Gene

Sources for FOXO1 Gene

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