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Aliases for FOXN4 Gene

Aliases for FOXN4 Gene

  • Forkhead Box N4 2 3 5

External Ids for FOXN4 Gene

Previous GeneCards Identifiers for FOXN4 Gene

  • GC12M108775
  • GC12M109554
  • GC12M108180
  • GC12M108178
  • GC12M109715
  • GC12M106733

Summaries for FOXN4 Gene

Entrez Gene Summary for FOXN4 Gene

  • Members of the winged-helix/forkhead family of transcription factors, such as FOXN4, are characterized by a 110-amino acid DNA-binding domain that can fold into a variant of the helix-turn-helix motif consisting of 3 alpha helices flanked by 2 large loops or wings. These transcription factors are involved in a variety of biologic processes as key regulators in development and metabolism (Li et al., 2004 [PubMed 15363391]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FOXN4 Gene

FOXN4 (Forkhead Box N4) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is FOXN2.

UniProtKB/Swiss-Prot for FOXN4 Gene

  • Transcription factor essential for neural and some non-neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5-ACGC-3. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4-NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXN4 Gene

Genomics for FOXN4 Gene

Regulatory Elements for FOXN4 Gene

Enhancers for FOXN4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FOXN4 on UCSC Golden Path with GeneCards custom track

Genomic Location for FOXN4 Gene

Chromosome:
12
Start:
109,277,978 bp from pter
End:
109,310,490 bp from pter
Size:
32,513 bases
Orientation:
Minus strand

Genomic View for FOXN4 Gene

Genes around FOXN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXN4 Gene

Proteins for FOXN4 Gene

  • Protein details for FOXN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NZ1-FOXN4_HUMAN
    Recommended name:
    Forkhead box protein N4
    Protein Accession:
    Q96NZ1
    Secondary Accessions:
    • Q6ZMR4
    • Q96NZ0

    Protein attributes for FOXN4 Gene

    Size:
    517 amino acids
    Molecular mass:
    55215 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FOXN4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXN4 Gene

Proteomics data for FOXN4 Gene at MOPED

Post-translational modifications for FOXN4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXN4 Gene

No data available for DME Specific Peptides for FOXN4 Gene

Domains & Families for FOXN4 Gene

Gene Families for FOXN4 Gene

Protein Domains for FOXN4 Gene

Suggested Antigen Peptide Sequences for FOXN4 Gene

Graphical View of Domain Structure for InterPro Entry

Q96NZ1

UniProtKB/Swiss-Prot:

FOXN4_HUMAN :
  • Contains 1 fork-head DNA-binding domain.
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXN4: view

Function for FOXN4 Gene

Molecular function for FOXN4 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor essential for neural and some non-neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5-ACGC-3. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4-NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development (By similarity).
genes like me logo Genes that share phenotypes with FOXN4: view

Animal Models for FOXN4 Gene

MGI Knock Outs for FOXN4:

Animal Model Products

miRNA for FOXN4 Gene

miRTarBase miRNAs that target FOXN4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOXN4 Gene

Localization for FOXN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXN4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXN4 Gene COMPARTMENTS Subcellular localization image for FOXN4 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for FOXN4 Gene

Pathways & Interactions for FOXN4 Gene

SuperPathways for FOXN4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001947 heart looping ISS --
GO:0010842 retina layer formation IEA,ISS --
GO:0030154 cell differentiation IEA --
GO:0036302 atrioventricular canal development ISS --
GO:0048663 neuron fate commitment IEA --
genes like me logo Genes that share ontologies with FOXN4: view

No data available for Pathways by source and SIGNOR curated interactions for FOXN4 Gene

Drugs & Compounds for FOXN4 Gene

No Compound Related Data Available

Transcripts for FOXN4 Gene

mRNA/cDNA for FOXN4 Gene

Unigene Clusters for FOXN4 Gene

Forkhead box N4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXN4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: -
SP2: - -
SP3:
SP4: - - -

Relevant External Links for FOXN4 Gene

GeneLoc Exon Structure for
FOXN4
ECgene alternative splicing isoforms for
FOXN4

Expression for FOXN4 Gene

mRNA expression in normal human tissues for FOXN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXN4 Gene

This gene is overexpressed in Testis (x29.6) and Cervix - Ectocervix (x4.2).

SOURCE GeneReport for Unigene cluster for FOXN4 Gene Hs.528316

genes like me logo Genes that share expression patterns with FOXN4: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FOXN4 Gene

Orthologs for FOXN4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FOXN4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOXN4 35
  • 88.78 (n)
  • 90.33 (a)
FOXN4 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXN4 35
  • 88.85 (n)
  • 90.47 (a)
FOXN4 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxn4 35
  • 81.3 (n)
  • 80.85 (a)
Foxn4 16
Foxn4 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FOXN4 35
  • 99.55 (n)
  • 99.61 (a)
FOXN4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxn4 35
  • 82.31 (n)
  • 81.53 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 12 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia FOXN4 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOXN4 35
  • 71.36 (n)
  • 70.24 (a)
FOXN4 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXN4 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia foxn4 35
  • 65.14 (n)
  • 62.08 (a)
zebrafish
(Danio rerio)
Actinopterygii foxn4 35
  • 63.51 (n)
  • 61.32 (a)
foxn4 36
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta jumu 36
  • 19 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FHL1 36
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 72 (a)
OneToMany
Species with no ortholog for FOXN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXN4 Gene

ENSEMBL:
Gene Tree for FOXN4 (if available)
TreeFam:
Gene Tree for FOXN4 (if available)

Paralogs for FOXN4 Gene

Paralogs for FOXN4 Gene

(14) SIMAP similar genes for FOXN4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FOXN4: view

Variants for FOXN4 Gene

Sequence variations from dbSNP and Humsavar for FOXN4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs11609341 - 109,287,902(+) GATGC(A/G)GCGGG reference, missense
rs2075436 -- 109,280,514(-) GTCCT(C/G)TTGTT intron-variant
rs2075437 -- 109,279,642(-) AACCC(C/T)GGCAC utr-variant-3-prime
rs2075438 -- 109,279,405(-) TCCCC(C/T)GACCC utr-variant-3-prime
rs2083068 -- 109,301,301(-) GGCAC(A/C)TATGG intron-variant

Variation tolerance for FOXN4 Gene

Residual Variation Intolerance Score: 74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.82% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for FOXN4 Gene

Disorders for FOXN4 Gene

Relevant External Links for FOXN4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXN4

No disorders were found for FOXN4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXN4 Gene

Publications for FOXN4 Gene

  1. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4 67
  2. Forkhead box N4 (Foxn4) activates Dll4-Notch signaling to suppress photoreceptor cell fates of early retinal progenitors. (PMID: 22323600) Luo H. … Xiang M. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors. (PMID: 15363391) Li S. … Xiang M. (Neuron 2004) 3
  5. Expression of the winged helix/forkhead gene, foxn4, during zebrafish development. (PMID: 15464224) Danilova N. … Steiner L.A. (Brain Res. Dev. Brain Res. 2004) 3

Products for FOXN4 Gene

Sources for FOXN4 Gene

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