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FOXN4 Gene

protein-coding   GIFtS: 45
GCID: GC12M109715

Forkhead Box N4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Forkhead Box N41 2
Forkhead Box Protein N42
Forkhead/Winged Helix Transcription Factor FOXN42

External Ids:    HGNC: 213991   Entrez Gene: 1216432   Ensembl: ENSG000001394457   OMIM: 6094295   UniProtKB: Q96NZ13   

Export aliases for FOXN4 gene to outside databases

Previous GC identifers: GC12M108775 GC12M109554 GC12M108180 GC12M108178 GC12M106733


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FOXN4 Gene:
Members of the winged-helix/forkhead family of transcription factors, such as FOXN4, are characterized by a
110-amino acid DNA-binding domain that can fold into a variant of the helix-turn-helix motif consisting of 3
alpha helices flanked by 2 large loops or wings. These transcription factors are involved in a variety of
biologic processes as key regulators in development and metabolism (Li et al., 2004 (PubMed 15363391)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for FOXN4 Gene:
FOXN4 (forkhead box N4) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOXF1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the FOXN4 gene promoter:
         AML1a   FOXO4   FOXO1a   Ik-3   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOXN4 promoter sequence
   Search Chromatin IP Primers for FOXN4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FOXN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.11   Ensembl cytogenetic band:  12q24.11   HGNC cytogenetic band: 12q24.12

FOXN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXN4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M109715:  view genomic region     (about GC identifiers)

Start:
109,715,783 bp from pter      End:
109,747,025 bp from pter
Size:
31,243 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FOXN4_HUMAN, Q96NZ1 (See protein sequence)
Recommended Name: Forkhead box protein N4  
Size: 517 amino acids; 55215 Da
Sequence caution: Sequence=BAD18661.1; Type=Erroneous initiation;
Secondary accessions: Q6ZMR4 Q96NZ0
Alternative splicing: 2 isoforms:  Q96NZ1-1   Q96NZ1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FOXN4: NX_Q96NZ1

Explore proteomics data for FOXN4 at MOPED


See FOXN4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_998761.2  
ENSEMBL proteins: 
 ENSP00000474754   ENSP00000347354   ENSP00000299162   ENSP00000408085  

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LSBio Antibodies in human, mouse, rat for FOXN4

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Cloud-Clone Corp. ELISAs for FOXN4
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Search eBioscience for ELISAs for FOXN4 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
FOX: Forkhead boxes

3 InterPro protein domains:
 IPR011991 WHTH_DNA-bd_dom
 IPR018122 TF_fork_head_CS
 IPR001766 TF_fork_head

Graphical View of Domain Structure for InterPro Entry Q96NZ1

ProtoNet protein and cluster: Q96NZ1

UniProtKB/Swiss-Prot: FOXN4_HUMAN, Q96NZ1
Similarity: Contains 1 fork-head DNA-binding domain


Find genes that share domains with FOXN4           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001158enhancer sequence-specific DNA binding ISS--
GO:0003682chromatin binding ISS--
GO:0003700sequence-specific DNA binding transcription factor activity ISS--
GO:0043565sequence-specific DNA binding ----
     
Find genes that share ontologies with FOXN4           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for FOXN4:
 Decreased viability with pacli 

     4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Foxn4):
 cellular  mortality/aging  nervous system  vision/eye 

Find genes that share phenotypes with FOXN4           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Foxn4tm1Xia for FOXN4

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FOXN4
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FOXN4

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FOXN4
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FOXN4

miRNA
Products:
    
miRTarBase miRNAs that target FOXN4:
hsa-mir-615-3p (MIRT040225), hsa-mir-1 (MIRT024081), hsa-mir-148b-3p (MIRT019471)

Block miRNA regulation of human, mouse, rat FOXN4 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate FOXN4 (see all 10):
hsa-miR-520f hsa-miR-513a-5p hsa-miR-27a hsa-miR-513a-3p hsa-miR-128 hsa-miR-3681* hsa-miR-144 hsa-miR-149
SwitchGear 3'UTR luciferase reporter plasmidFOXN4 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for FOXN4
Predesigned siRNA for gene silencing in human, mouse, rat FOXN4

Gene Editing
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Clone
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Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXN4


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
FOXN4_HUMAN, Q96NZ1: Nucleus (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol2

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus ISS--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FOXN4
Interactions:

    Search GeneGlobe Interaction Network for FOXN4

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for FOXN4 (ENSP000002991624) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
UBE2IENSP000003248974STRING: ENSP00000324897
BMPR2ENSP000003637084STRING: ENSP00000363708
ASCL1ENSP000002667444STRING: ENSP00000266744
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Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001947heart looping ISS--
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated ISS--
GO:0008016regulation of heart contraction ISS--
GO:0010842retina layer formation ISS--

Find genes that share ontologies with FOXN4           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for FOXN4



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for FOXN4 gene: 
NM_213596.2  

Unigene Cluster for FOXN4:

Forkhead box N4
Hs.528316  [show with all ESTs]
Unigene Representative Sequence: BC146825
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000468516 ENST00000355216(uc001tof.4) ENST00000299162(uc009zvg.3 uc001toe.4)
ENST00000423960
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat FOXN4 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate FOXN4 (see all 10):
hsa-miR-520f hsa-miR-513a-5p hsa-miR-27a hsa-miR-513a-3p hsa-miR-128 hsa-miR-3681* hsa-miR-144 hsa-miR-149
SwitchGear 3'UTR luciferase reporter plasmidFOXN4 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for FOXN4
Predesigned siRNA for gene silencing in human, mouse, rat FOXN4
Clone
Products:
     
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OriGene ORF clones in mouse, rat for FOXN4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: FOXN4 (NM_213596)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXN4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXN4
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for FOXN4
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FOXN4
  QuantiTect SYBR Green Assays in human, mouse, rat FOXN4
  QuantiFast Probe-based Assays in human, mouse, rat FOXN4

Additional mRNA sequence: 

AF425596.1 AF425597.1 AK093286.1 AK131519.1 BC113073.1 BC146825.1 

2 DOTS entries:

DT.99974511  DT.95259358 

14 AceView cDNA sequences:

BU156681 AI805494 AK093286 AF425596 AF425597 AI221704 AA421371 AK131519 
NM_213596 AW117425 AI243313 AI187920 AA421288 BX096551 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for FOXN4    About this scheme

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1:                                      -                                                   
SP2:                                      -     -                                             
SP3:                                                                                          
SP4:                                                                    -     -     -         


ECgene alternative splicing isoforms for FOXN4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FOXN4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACCCCTGATA
FOXN4 Expression
About this image


FOXN4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Eye (Sensory Organs)    fully expand to see all 3 entries
         Late Amacrine Horizontal Precursor Cells Retinal Neuroblastic Layer
         Retina
 
 Neurons
         Late Amacrine Horizontal Precursor Cells Retinal Neuroblastic Layer
FOXN4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

FOXN4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.528316
    Custom PCR Arrays for FOXN4
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXN4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for FOXN4 gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Foxn41 , 5 forkhead box N41, 5 81.3(n)1
80.85(a)1
  5 (55.99 cM)5
1168101  NM_148935.21  NP_683737.21 
 1142541645 
chicken
(Gallus gallus)
Aves FOXN41 forkhead box N4 71.36(n)
70.24(a)
  416898  NM_001083359.1  NP_001076828.1 
lizard
(Anolis carolinensis)
Reptilia FOXN46
forkhead box N4
63(a)
1 ↔ 1
AAWZ02041607(425-5471)
tropical clawed frog
(Xenopus tropicalis)
Amphibia foxn41 forkhead box N4 65.14(n)
62.08(a)
  100124918  NM_001102862.1  NP_001096332.1 
zebrafish
(Danio rerio)
Actinopterygii foxn42 forkhead box N4 75.58(n)   30315  AF198446.2 
fruit fly
(Drosophila melanogaster)
Insecta jumu6
jumeau
19(a)
1 → many
3R(6175906-6187343)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FHL16
Regulator of ribosomal protein transcription; has ...
9(a)
1 → many
XVI(733623-736433) YPR104C


ENSEMBL Gene Tree for FOXN4 (if available)
TreeFam Gene Tree for FOXN4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for FOXN4 gene
FOXF12  FOXQ12  FOXN32  FOXJ12  FOXF22  FOXK12  FOXR12  FOXH12  
FOXK22  FOXN12  FOXJ32  FOXG12  FOXJ22  FOXN22  FOXR22  
14 SIMAP similar genes for FOXN4 using alignment to 4 protein entries:     FOXN4_HUMAN (see all proteins):
FOXN3    FOXN2    FOXL1    FOXC2    FOXA1    FOXC1
FOXP4    FOXD1    FOXK2    FOXP2    FOXP1    FOXJ3
FOXI1    FOXI2

Find genes that share paralogs with FOXN4           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FOXN4 (see all 660)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1431480011,2
C--109715321(+) CTGTT-/AATGAG 1 -- int10--------
rs342906291,2
C,F--109715441(+) CCTGAG/TCTGTG 1 -- int13Minor allele frequency- T:0.20NA 10
rs1811159711,2
--109715801(+) TTATTA/GATAGA 1 -- ut310--------
rs1468536311,2
C--109715868(+) TGTGAA/GTAACA 1 -- ut310--------
rs592264971,2
C,F--109715932(+) TCAGAC/AGGGTA 1 -- ut311Minor allele frequency- A:0.50WA 2
rs1503318601,2
--109716104(+) CTCCCA/GGACAC 1 -- ut310--------
rs776631971,2
C--109716292(+) GAGAGA/GAAAAG 1 -- ut313Minor allele frequency- G:0.07CSA WA EA 240
rs110660731,2
C,F,A,H--109716331(+) GAGGTG/AAGGAA 1 -- ut31 ese38Minor allele frequency- A:0.33NA WA EA 370
rs1378930731,2
C--109716390(+) GGTTCA/GAGCTT 1 -- ut310--------
rs606899981,2
C--109716455(+) AAGCA-/CCCCCC 1 -- ut310--------

HapMap Linkage Disequilibrium report for FOXN4 (109715783 - 109747025 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for FOXN4: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing FOXN4
DNA2.0 Custom Variant and Variant Library Synthesis for FOXN4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 609429    OMIM disorders: --


Find genes that share disorders with FOXN4           About GenesLikeMe


Export disorders for FOXN4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FOXN4 gene integrated from 10 sources:
(articles sorted by number of sources associating them with FOXN4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (Nature 2006)
  2. Expression of the winged helix/forkhead gene, foxn4, during zebrafish development. (PubMed id 15464224)1, 2 Danilova N.... Steiner L.A. (Brain Res. Dev. Brain Res. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Characterization of human FOXN4 gene in silico. (PubMed id 15492871)1 Katoh M. and Katoh M. (Int. J. Mol. Med. 2004)
  5. Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors. (PubMed id 15363391)1 Li S....Xiang M. (Neuron 2004)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 121643 HGNC: 21399 AceView: FOXN4 Ensembl:ENSG00000139445 euGenes: HUgn121643
ECgene: FOXN4 H-InvDB: FOXN4

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FOXN4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for FOXN4 gene:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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