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FOXN3 Gene

protein-coding   GIFtS: 51
GCID: GC14M090293

Forkhead Box N3

(Previous names: chromosome 14 open reading frame 116, checkpoint suppressor...)
(Previous symbols: C14orf116, CHES1)
  See FOXN3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Forkhead Box N31 2     Chromosome 14 Open Reading Frame 1161
CHES11 2 3 5     PRO16352
Checkpoint Suppressor 11 2 3     Forkhead Box Protein N32
C14orf1161 2 3     

External Ids:    HGNC: 19281   Entrez Gene: 11122   Ensembl: ENSG000000532547   OMIM: 6026285   UniProtKB: O004093   

Export aliases for FOXN3 gene to outside databases

Previous GC identifers: GC14M088692 GC14M089622 GC14M069797 GC14M089706 GC14M089882


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FOXN3 Gene:
This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA
damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint
mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative
splicing is observed at the locus, resulting in distinct isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for FOXN3 Gene:
FOXN3 (forkhead box N3) is a protein-coding gene. Diseases associated with FOXN3 include auditory neuropathy. GO annotations related to this gene include protein C-terminus binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOXF1.

UniProtKB/Swiss-Prot: FOXN3_HUMAN, O00409
Function: Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests
(checkpoints)

Gene Wiki entry for FOXN3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the FOXN3 gene promoter:
         AP-2alpha isoform 3   Bach2   AP-2alpha isoform 2   C/EBPalpha   AREB6   FOXO4   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): FOXN3 promoter sequence
   Search Chromatin IP Primers for FOXN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FOXN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q31.3   Ensembl cytogenetic band:  14q32.11   HGNC cytogenetic band: 14q32.11

FOXN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXN3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M090293:  view genomic region     (about GC identifiers)

Start:
89,591,215 bp from pter      End:
90,085,494 bp from pter
Size:
494,280 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FOXN3_HUMAN, O00409 (See protein sequence)
Recommended Name: Forkhead box protein N3  
Size: 490 amino acids; 53835 Da
Subunit: Interacts through its C-terminus with the C-terminus of SNW1/SKIP
Secondary accessions: Q96II7 Q9UIE7
Alternative splicing: 2 isoforms:  O00409-1   O00409-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FOXN3: NX_O00409

Explore proteomics data for FOXN3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FOXN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001078940.1  NP_005188.2  

    ENSEMBL proteins: 
     ENSP00000450783   ENSP00000343288   ENSP00000452005   ENSP00000452227   ENSP00000450833  
     ENSP00000451437   ENSP00000452444   ENSP00000450684   ENSP00000451024   ENSP00000451135  
     ENSP00000452290   ENSP00000451902   ENSP00000261302  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FOX: Forkhead boxes

    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry O00409

    ProtoNet protein and cluster: O00409

    UniProtKB/Swiss-Prot: FOXN3_HUMAN, O00409
    Similarity: Contains 1 fork-head DNA-binding domain


    Find genes that share domains with FOXN3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOXN3_HUMAN, O00409
    Function: Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests
    (checkpoints)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI16102918
    GO:0008022protein C-terminus binding IPI16951149
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with FOXN3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FOXN3:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FOXN3
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    miRNA
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    miRTarBase miRNAs that target FOXN3:
    hsa-mir-21-5p (MIRT030800), hsa-mir-92b-3p (MIRT040561), hsa-mir-574-5p (MIRT007196)

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    Selected qRT-PCR Assays for microRNAs that regulate FOXN3 (see all 204):
    hsa-miR-640 hsa-miR-605 hsa-miR-128 hsa-miR-3653 hsa-miR-138-2* hsa-miR-759 hsa-miR-508-5p hsa-miR-3649
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FOXN3_HUMAN, O00409: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IC16102918

    Find genes that share ontologies with FOXN3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FOXN3
    Interactions:

        Search GeneGlobe Interaction Network for FOXN3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for FOXN3 (O004091, 3 ENSP000002613024) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOSC8Q96B263, ENSP000003743544I2D: score=2 STRING: ENSP00000374354
    MEN1O002553, ENSP000003370884I2D: score=1 STRING: ENSP00000337088
    CDC23Q9UJX23I2D: score=1 
    SNW1Q135731EBI-372721,EBI-632715
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000077DNA damage checkpoint TAS9154802
    GO:0000085mitotic G2 phase TAS9154802
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0045892negative regulation of transcription, DNA-templated IDA16102918

    Find genes that share ontologies with FOXN3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FOXN3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FOXN3 gene (2 alternative transcripts): 
    NM_001085471.1  NM_005197.3  

    Unigene Cluster for FOXN3:

    Forkhead box N3
    Hs.434286  [show with all ESTs]
    Unigene Representative Sequence: NM_005197
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000557572 ENST00000345097(uc001xxn.4 uc001xxo.4 uc010atk.3)
    ENST00000557258 ENST00000555353 ENST00000553840 ENST00000556541 ENST00000555010
    ENST00000557496 ENST00000557718 ENST00000553353 ENST00000556916 ENST00000555658
    ENST00000554005 ENST00000557261 ENST00000555855(uc001xxp.2) ENST00000555034
    ENST00000553904 ENST00000261302
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FOXN3 (see all 204):
    hsa-miR-640 hsa-miR-605 hsa-miR-128 hsa-miR-3653 hsa-miR-138-2* hsa-miR-759 hsa-miR-508-5p hsa-miR-3649
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    Addgene plasmids for FOXN3 
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      QuantiTect SYBR Green Assays in human, mouse, rat FOXN3
      QuantiFast Probe-based Assays in human, mouse, rat FOXN3

    Additional mRNA sequence: 

    AF116643.2 AK055175.1 AK123929.1 AK225967.1 AK308053.1 AK314098.1 BC007506.2 BC010227.1 
    BC010460.1 U68723.1 

    23 DOTS entries:

    DT.95364202  DT.100780283  DT.99975505  DT.101960788  DT.120784181  DT.120784076  DT.92430326  DT.40121707 
    DT.121089966  DT.91702420  DT.120784334  DT.91702406  DT.100795350  DT.118147  DT.120784245  DT.92430313 
    DT.120783936  DT.121290117  DT.91702408  DT.95076327  DT.100780286  DT.120783971  DT.120784219 

    Selected AceView cDNA sequences (see all 276):

    BX117076 AL598391 AA282818 AL704050 CB850980 BM836262 AA463714 BX117138 
    AA827174 AA460191 BF439893 AA889054 BQ007503 AI240081 BQ055277 BM728055 
    BX283610 AA568842 AA760976 AA017395 BU172864 AA564019 AI917297 AW241326 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FOXN3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:              -                 -           -     -               
    SP2:              -                 -           -                     
    SP3:                                                                  
    SP4:                                -                                 


    ECgene alternative splicing isoforms for FOXN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FOXN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAACCTAAA
    FOXN3 Expression
    About this image


    FOXN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Peripheral blood-derived hematopoietic stem cells (family)
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Neurons
             Mature Rod Bipolar Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             Mature Rod Bipolar Cells Inner Nuclear Layer
    FOXN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FOXN3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.434286
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FOXN3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Foxn35 forkhead box N3   --   12 (49.93 cM) 99194980 
    chicken
    (Gallus gallus)
    Aves FOXN31 forkhead box N3 83.13(n)
    88.73(a)
      423402  XM_003641309.2  XP_003641357.2 
    lizard
    (Anolis carolinensis)
    Reptilia FOXN36
    forkhead box N3
    87(a)
    1 ↔ 1
    1(13068336-13243881)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia foxn31 forkhead box N3 77.69(n)
    83.16(a)
      549054  NM_001016300.3  NP_001016300.2 
    zebrafish
    (Danio rerio)
    Actinopterygii foxn31 forkhead box N3 77.69(n)
    83.87(a)
      692291  NM_001045263.1  NP_001038728.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CHES-1-like6
    Checkpoint suppressor homologue
    12(a)
    1 → many
    X(7576371-7603418)


    ENSEMBL Gene Tree for FOXN3 (if available)
    TreeFam Gene Tree for FOXN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FOXN3 gene
    FOXF12  FOXQ12  FOXJ12  FOXF22  FOXK12  FOXN42  FOXR12  FOXH12  
    FOXK22  FOXN12  FOXJ32  FOXG12  FOXJ22  FOXN22  FOXR22  
    10 SIMAP similar genes for FOXN3 using alignment to 10 protein entries:     FOXN3_HUMAN (see all proteins):
    FOXN4    FOXL1    FOXC2    FOXJ3    FOXI1    FOXD1
    FOXN2    FOXC1    FOXK2    FOXP2

    Find genes that share paralogs with FOXN3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for FOXN3
    PGOHUM00000241477


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FOXN3 (see all 10027)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs589306771,2
    C--69929009(+) AAAAA-/A/    
       AAAAA
    GTAAC
    2 -- int11NA 2
    rs678823231,2
    C--70055563(-) AACTG-/T/TTT 
    TTTTTTTT
    TTTTT
    2 -- int11NA 2
    rs343750931,2
    C--70786845(+) ACACA-/AG/G  
            
    CATTC
    2 -- int11NA 2
    rs1875188501,2
    --70867649(+) AGCGCA/GGGGAG 1 -- int10--------
    rs585724751,2
    C--70867784(+) GCCCCC/TCGCGC 1 -- int10--------
    rs1428432551,2
    C--70867801(+) GCACTC/GAGCCA 1 -- int10--------
    rs101361701,2
    C,F--70869512(+) TGCATT/CCTCAA 1 -- int12Minor allele frequency- C:0.06WA NA 238
    rs1881022461,2
    --70869520(+) CAAACA/GTATTT 1 -- int10--------
    rs101470131,2
    C--70869605(+) CAGCCC/TTGCCT 1 -- int12Minor allele frequency- T:0.15WA 120
    rs1458888821,2
    C--70869748(+) TGCTTC/GCTGAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for FOXN3 (89591215 - 89841215 bp, first 250kb of FOXN3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FOXN3 (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1482284CNV Deletion17803354
    esv1491660CNV Deletion17803354
    esv1552920CNV Deletion17803354
    esv2668092CNV Deletion23128226
    esv2749001CNV Deletion23290073
    esv1206899CNV Deletion17803354
    esv1600275CNV Deletion17803354
    esv2672523CNV Deletion23128226
    esv1516315CNV Deletion17803354
    esv1407895CNV Deletion17803354

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602628    OMIM disorders: --

    1 disease for FOXN3:    
    About MalaCards
    auditory neuropathy


    Find genes that share disorders with FOXN3           About GenesLikeMe

    2 Novoseek inferred disease relationships for FOXN3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 11 1 16102918 (1)
    cancer 8.17 3 16102918 (2)

    Genetic Association Database (GAD): FOXN3
    Human Genome Epidemiology (HuGE) Navigator: FOXN3 (2 documents)

    Export disorders for FOXN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FOXN3 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with FOXN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA. (PubMed id 9154802)1, 2, 3, 9 Pati D.... Plon S.E. (Mol. Cell. Biol. 1997)
    2. CHES1/FOXN3 interacts with Ski-interacting protein and acts as a transcriptional repressor. (PubMed id 16102918)1, 2, 9 Scott K.L. and Plon S.E. (Gene 2005)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)
    7. Multiple endocrine neoplasia type 1 interacts with forkhead transcription factor CHES1 in DNA damage response. (PubMed id 16951149)1, 9 Busygina V....Bale A.E. (Cancer Res. 2006)
    8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    9. Weight loss after gastric bypass is associated with a variant at 15q26.1. (PubMed id 23643386)1 Hatoum I.J....Kaplan L.M. (Am. J. Hum. Genet. 2013)
    10. MicroRNA-574-5p was pivotal for TLR9 signaling enhanced tumor progression via down-regulating checkpoint suppressor 1 in human lung cancer. (PubMed id 23133627)1 Li Q....Ren T. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1112 HGNC: 1928 AceView: CHES1 Ensembl:ENSG00000053254 euGenes: HUgn1112
    ECgene: FOXN3 H-InvDB: FOXN3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FOXN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FOXN3 gene:
    Search GeneIP for patents involving FOXN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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