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Aliases for FOXN3 Gene

Aliases for FOXN3 Gene

  • Forkhead Box N3 2 3 5
  • Checkpoint Suppressor 1 2 3 4
  • C14orf116 3 4
  • CHES1 3 4
  • Chromosome 14 Open Reading Frame 116 2
  • PRO1635 3

External Ids for FOXN3 Gene

Previous HGNC Symbols for FOXN3 Gene

  • C14orf116
  • CHES1

Previous GeneCards Identifiers for FOXN3 Gene

  • GC14M088692
  • GC14M089622
  • GC14M069797
  • GC14M089706
  • GC14M089882
  • GC14M090293
  • GC14M089149
  • GC14M089255

Summaries for FOXN3 Gene

Entrez Gene Summary for FOXN3 Gene

  • This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXN3 Gene

FOXN3 (Forkhead Box N3) is a Protein Coding gene. Diseases associated with FOXN3 include Auditory Neuropathy. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein C-terminus binding. An important paralog of this gene is FOXN2.

UniProtKB/Swiss-Prot for FOXN3 Gene

  • Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).

Gene Wiki entry for FOXN3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXN3 Gene

Genomics for FOXN3 Gene

Regulatory Elements for FOXN3 Gene

Enhancers for FOXN3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FOXN3 on UCSC Golden Path with GeneCards custom track

Promoters for FOXN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FOXN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for FOXN3 Gene

Chromosome:
14
Start:
89,124,871 bp from pter
End:
89,619,150 bp from pter
Size:
494,280 bases
Orientation:
Minus strand

Genomic View for FOXN3 Gene

Genes around FOXN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXN3 Gene

Proteins for FOXN3 Gene

  • Protein details for FOXN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00409-FOXN3_HUMAN
    Recommended name:
    Forkhead box protein N3
    Protein Accession:
    O00409
    Secondary Accessions:
    • Q96II7
    • Q9UIE7

    Protein attributes for FOXN3 Gene

    Size:
    490 amino acids
    Molecular mass:
    53835 Da
    Quaternary structure:
    • Interacts through its C-terminus with the C-terminus of SNW1/SKIP.

    Alternative splice isoforms for FOXN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXN3 Gene

Proteomics data for FOXN3 Gene at MOPED

Post-translational modifications for FOXN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FOXN3 Gene

Domains & Families for FOXN3 Gene

Gene Families for FOXN3 Gene

Protein Domains for FOXN3 Gene

Suggested Antigen Peptide Sequences for FOXN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00409

UniProtKB/Swiss-Prot:

FOXN3_HUMAN :
  • Contains 1 fork-head DNA-binding domain.
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXN3: view

Function for FOXN3 Gene

Molecular function for FOXN3 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).

Gene Ontology (GO) - Molecular Function for FOXN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 16102918
genes like me logo Genes that share ontologies with FOXN3: view

Phenotypes for FOXN3 Gene

genes like me logo Genes that share phenotypes with FOXN3: view

Animal Model Products

miRNA for FOXN3 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FOXN3 Gene

Localization for FOXN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXN3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXN3 Gene COMPARTMENTS Subcellular localization image for FOXN3 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for FOXN3 Gene

Pathways & Interactions for FOXN3 Gene

SuperPathways for FOXN3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated IDA 16102918
genes like me logo Genes that share ontologies with FOXN3: view

No data available for Pathways by source and SIGNOR curated interactions for FOXN3 Gene

Drugs & Compounds for FOXN3 Gene

No Compound Related Data Available

Transcripts for FOXN3 Gene

Unigene Clusters for FOXN3 Gene

Forkhead box N3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXN3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - - -
SP2: - - -
SP3:
SP4: -

Relevant External Links for FOXN3 Gene

GeneLoc Exon Structure for
FOXN3
ECgene alternative splicing isoforms for
FOXN3

Expression for FOXN3 Gene

mRNA expression in normal human tissues for FOXN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FOXN3 Gene



SOURCE GeneReport for Unigene cluster for FOXN3 Gene Hs.434286

genes like me logo Genes that share expression patterns with FOXN3: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FOXN3 Gene

Orthologs for FOXN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXN3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia FOXN3 35
  • 92.01 (n)
  • 93.65 (a)
-- 36
  • 94 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia FOXN3 35
  • 99.52 (n)
  • 99.8 (a)
FOXN3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FOXN3 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FOXN3 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxn3 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOXN3 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOXN3 35
  • 83.13 (n)
  • 88.73 (a)
FOXN3 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXN3 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia foxn3 35
  • 77.69 (n)
  • 83.16 (a)
zebrafish
(Danio rerio)
Actinopterygii foxn3 35
  • 77.69 (n)
  • 83.87 (a)
foxn3 36
  • 74 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CHES-1-like 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5413 36
  • 23 (a)
OneToMany
Species with no ortholog for FOXN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXN3 Gene

ENSEMBL:
Gene Tree for FOXN3 (if available)
TreeFam:
Gene Tree for FOXN3 (if available)

Paralogs for FOXN3 Gene

Paralogs for FOXN3 Gene

Pseudogenes.org Pseudogenes for FOXN3 Gene

genes like me logo Genes that share paralogs with FOXN3: view

Variants for FOXN3 Gene

Sequence variations from dbSNP and Humsavar for FOXN3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1804717 - 89,162,878(-) ACAAC(C/T)ACAGC reference, missense
rs9589 -- 89,156,341(-) GCATC(C/T)ATACC utr-variant-3-prime
rs20496 -- 89,305,293(+) CAGAA(C/T)CCATC intron-variant
rs44812 -- 89,580,555(-) AGAAA(C/T)GAACT intron-variant
rs53976 -- 89,529,004(+) AGTAT(A/G)TCATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOXN3 Gene

Variant ID Type Subtype PubMed ID
nsv832851 CNV Gain 17160897
esv2749001 CNV Deletion 23290073
nsv526326 CNV Loss 19592680
esv2749002 CNV Deletion 23290073
nsv528176 CNV Loss 19592680
nsv85548 CNV Loss 16902084
nsv512369 CNV Loss 21212237
esv1286606 CNV Insertion 17803354
esv1206899 CNV Deletion 17803354
esv2672523 CNV Deletion 23128226
esv1378771 CNV Deletion 17803354
esv1600275 CNV Deletion 17803354
esv1552920 CNV Deletion 17803354
esv2668092 CNV Deletion 23128226
esv1407895 CNV Deletion 17803354
esv1516315 CNV Deletion 17803354
esv1482284 CNV Deletion 17803354
esv1491660 CNV Deletion 17803354
esv275436 CNV Loss 21479260
nsv832852 CNV Gain 17160897
nsv442354 CNV CNV 18776908
esv27509 CNV Loss 19812545
nsv85015 CNV Loss 16902084
esv2666528 CNV Deletion 23128226
esv1459170 CNV Deletion 17803354

Variation tolerance for FOXN3 Gene

Residual Variation Intolerance Score: 28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.52% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FOXN3 Gene

Disorders for FOXN3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FOXN3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
auditory neuropathy
  • auditory dys-synchrony
- elite association - COSMIC cancer census association via MalaCards
Search FOXN3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FOXN3

Genetic Association Database (GAD)
FOXN3
Human Genome Epidemiology (HuGE) Navigator
FOXN3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXN3
genes like me logo Genes that share disorders with FOXN3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOXN3 Gene

Publications for FOXN3 Gene

  1. Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA. (PMID: 9154802) Pati D. … Plon S.E. (Mol. Cell. Biol. 1997) 2 3 4 23 67
  2. Multiple endocrine neoplasia type 1 interacts with forkhead transcription factor CHES1 in DNA damage response. (PMID: 16951149) Busygina V. … Bale A.E. (Cancer Res. 2006) 3 23
  3. CHES1/FOXN3 interacts with Ski-interacting protein and acts as a transcriptional repressor. (PMID: 16102918) Scott K.L. … Plon S.E. (Gene 2005) 3 23
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  5. A Systematic Approach to Defining the microRNA Landscape in Metastasis. (PMID: 26069251) Mudduluru G. … Allgayer H. (Cancer Res. 2015) 3

Products for FOXN3 Gene

Sources for FOXN3 Gene

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