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Aliases for FOXN2 Gene

Aliases for FOXN2 Gene

  • Forkhead Box N2 2 3 5
  • Human T-Cell Leukemia Virus Enhancer Factor 2 3 4
  • HTLF 3 4
  • Forkhead Box Protein N2 3

External Ids for FOXN2 Gene

Previous HGNC Symbols for FOXN2 Gene

  • HTLF

Previous GeneCards Identifiers for FOXN2 Gene

  • GC02P048395
  • GC02P048541
  • GC02P048277

Summaries for FOXN2 Gene

Entrez Gene Summary for FOXN2 Gene

  • This gene encodes a forkhead domain binding protein and may function in the transcriptional regulation of the human T-cell leukemia virus long terminal repeat. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXN2 Gene

FOXN2 (Forkhead Box N2) is a Protein Coding gene. Diseases associated with FOXN2 include T-Cell Leukemia. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is FOXN3.

UniProtKB/Swiss-Prot for FOXN2 Gene

  • Binds to the purine-rich region in HTLV-I LTR.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXN2 Gene

Genomics for FOXN2 Gene

Regulatory Elements for FOXN2 Gene

Enhancers for FOXN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G048342 1.3 ENCODE dbSUPER 47.4 +30.2 30238 4.4 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 GATA2 FOXN2 PPP1R21 GTF2A1L GC02M048341 RNU4-49P GC02M048365
GH02G048405 0.7 ENCODE 53.8 +92.1 92093 1.5 TAL1 FOSL1 TCF12 ARID1B NFIC EGR1 NCOR1 KLF16 KDM1A TRIM24 FOXN2 PPP1R21 GTF2A1L GC02M048388 ENSG00000272663
GH02G048110 1.4 Ensembl ENCODE 23.1 -201.6 -201602 5.3 HDGF MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 FOXN2 PPP1R21 RNU6-282P GC02P048073 GC02P048218
GH02G048042 0.9 ENCODE 32.4 -270.9 -270865 2.1 ELF3 FOXA2 ATF1 ARID4B ZSCAN9 ZNF48 RAD21 RARA SLC30A9 GATA4 FOXN2 GTF2A1L PPP1R21 GC02M048066 LOC105374591
GH02G048414 1.5 Ensembl ENCODE dbSUPER 18.7 +101.0 100992 3.0 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 MXD4 MIER3 RFX3 PPP1R21 FOXN2 ENSG00000272663 GC02M048388
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FOXN2 on UCSC Golden Path with GeneCards custom track

Promoters for FOXN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000116913 563 3201 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Genomic Location for FOXN2 Gene

48,314,637 bp from pter
48,379,295 bp from pter
64,659 bases
Plus strand

Genomic View for FOXN2 Gene

Genes around FOXN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXN2 Gene

Proteins for FOXN2 Gene

  • Protein details for FOXN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Forkhead box protein N2
    Protein Accession:
    Secondary Accessions:
    • Q15769
    • Q6P4Q2

    Protein attributes for FOXN2 Gene

    431 amino acids
    Molecular mass:
    47161 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FOXN2 Gene


neXtProt entry for FOXN2 Gene

Post-translational modifications for FOXN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FOXN2 Gene

Domains & Families for FOXN2 Gene

Gene Families for FOXN2 Gene

Protein Domains for FOXN2 Gene

Suggested Antigen Peptide Sequences for FOXN2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FOXN2: view

No data available for UniProtKB/Swiss-Prot for FOXN2 Gene

Function for FOXN2 Gene

Molecular function for FOXN2 Gene

UniProtKB/Swiss-Prot Function:
Binds to the purine-rich region in HTLV-I LTR.

Gene Ontology (GO) - Molecular Function for FOXN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA,IEA --
GO:0005515 protein binding IPI 25609649
GO:0043565 sequence-specific DNA binding IBA,IEA --
genes like me logo Genes that share ontologies with FOXN2: view
genes like me logo Genes that share phenotypes with FOXN2: view

Animal Model Products

CRISPR Products

miRNA for FOXN2 Gene

miRTarBase miRNAs that target FOXN2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FOXN2 Gene

Localization for FOXN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXN2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXN2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for FOXN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with FOXN2: view

Pathways & Interactions for FOXN2 Gene

SuperPathways for FOXN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030154 cell differentiation IBA --
GO:0035914 skeletal muscle cell differentiation IEA --
GO:0045893 positive regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with FOXN2: view

No data available for Pathways by source and SIGNOR curated interactions for FOXN2 Gene

Drugs & Compounds for FOXN2 Gene

No Compound Related Data Available

Transcripts for FOXN2 Gene

Unigene Clusters for FOXN2 Gene

Forkhead box N2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXN2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP2: -

Relevant External Links for FOXN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FOXN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOXN2 Gene

Protein differential expression in normal tissues from HIPED for FOXN2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FOXN2 Gene

Protein tissue co-expression partners for FOXN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FOXN2 Gene:


SOURCE GeneReport for Unigene cluster for FOXN2 Gene:

genes like me logo Genes that share expression patterns with FOXN2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXN2 Gene

Orthologs for FOXN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FOXN2 35 34
  • 99.77 (n)
(Canis familiaris)
Mammalia FOXN2 34 35
  • 93.97 (n)
(Bos Taurus)
Mammalia FOXN2 34 35
  • 93.12 (n)
(Monodelphis domestica)
Mammalia FOXN2 35
  • 86 (a)
(Rattus norvegicus)
Mammalia Foxn2 34
  • 84.58 (n)
(Mus musculus)
Mammalia Foxn2 34 16 35
  • 84.46 (n)
(Gallus gallus)
Aves FOXN2 34 35
  • 81.71 (n)
(Anolis carolinensis)
Reptilia FOXN2 35
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia foxn2 34
  • 74.97 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.34746 34
(Danio rerio)
Actinopterygii LOC100330010 34
  • 62.83 (n)
CABZ01056728.1 35
  • 53 (a)
foxn2b 35
  • 51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CHES-1-like 35
  • 11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5413 35
  • 20 (a)
Species where no ortholog for FOXN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXN2 Gene

Gene Tree for FOXN2 (if available)
Gene Tree for FOXN2 (if available)

Paralogs for FOXN2 Gene

Paralogs for FOXN2 Gene

(3) SIMAP similar genes for FOXN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FOXN2: view

Variants for FOXN2 Gene

Sequence variations from dbSNP and Humsavar for FOXN2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000083464 -- 48,359,370(+) CTCAC(C/T)GCAAC intron-variant
rs1000149699 -- 48,345,584(+) TCATA(A/G)TATCA intron-variant
rs1000199145 -- 48,356,264(+) GGTGG(A/G)ACCCT intron-variant
rs1000203022 -- 48,370,251(+) CGGCT(C/G)CAACT intron-variant
rs1000223434 -- 48,365,011(+) AAATT(A/C/G)TGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOXN2 Gene

Variant ID Type Subtype PubMed ID
esv2762252 CNV gain 21179565
nsv519831 CNV gain 19592680
nsv953781 CNV duplication 24416366

Variation tolerance for FOXN2 Gene

Residual Variation Intolerance Score: 12.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXN2 Gene

Disorders for FOXN2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FOXN2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
t-cell leukemia
  • leukemia t-cell
- elite association - COSMIC cancer census association via MalaCards
Search FOXN2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FOXN2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FOXN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOXN2 Gene

Publications for FOXN2 Gene

  1. Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein HTLF. (PMID: 1639393) Li C. … Gaynor R.B. (Genomics 1992) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Helicase-like transcription factor is a RUNX1 target whose downregulation promotes genomic instability and correlates with complex cytogenetic features in acute myeloid leukemia. (PMID: 26802049) Cheng C.K. … Ng M.H. (Haematologica 2016) 3 64
  4. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3 64
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64

Products for FOXN2 Gene

Sources for FOXN2 Gene

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