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FOXN2 Gene

protein-coding   GIFtS: 49
GCID: GC02P048541

Forkhead Box N2

(Previous name: human T-cell leukemia virus enhancer factor)
(Previous symbol: HTLF)
  See FOXN2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Forkhead Box N21 2
HTLF1 2 3 5
Human T-Cell Leukemia Virus Enhancer Factor1 2 3
Forkhead Box Protein N22

External Ids:    HGNC: 52811   Entrez Gene: 33442   Ensembl: ENSG000001708027   OMIM: 1430895   UniProtKB: P323143   

Export aliases for FOXN2 gene to outside databases

Previous GC identifers: GC02P048395 GC02P048277


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FOXN2 Gene:
This gene encodes a forkhead domain binding protein and may function in the transcriptional regulation of the
human T-cell leukemia virus long terminal repeat. (provided by RefSeq, Jul 2008)

GeneCards Summary for FOXN2 Gene:
FOXN2 (forkhead box N2) is a protein-coding gene. Diseases associated with FOXN2 include t-cell leukemia, and leukemia. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOXF1.

UniProtKB/Swiss-Prot: FOXN2_HUMAN, P32314
Function: Binds to the purine-rich region in HTLV-I LTR




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FOXN2 gene promoter:
         FOXO4   FOXO1a   Lmo2   AP-4   FOXO1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOXN2 promoter sequence
   Search Chromatin IP Primers for FOXN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FOXN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22-p16   Ensembl cytogenetic band:  2p16.3   HGNC cytogenetic band: 2p22-p16

FOXN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXN2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P048541:  view genomic region     (about GC identifiers)

Start:
48,541,776 bp from pter      End:
48,606,434 bp from pter
Size:
64,659 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FOXN2_HUMAN, P32314 (See protein sequence)
Recommended Name: Forkhead box protein N2  
Size: 431 amino acids; 47161 Da
Secondary accessions: Q15769 Q6P4Q2
Alternative splicing: 2 isoforms:  P32314-1   P32314-2   

Explore the universe of human proteins at neXtProt for FOXN2: NX_P32314

Explore proteomics data for FOXN2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FOXN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002149.2  
    ENSEMBL proteins: 
     ENSP00000388486   ENSP00000343633  

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    Cloud-Clone Corp. Proteins for FOXN2

     
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    antibodies-online proteins for FOXN2 (2 products) 

     
    antibodies-online peptides for FOXN2

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    antibodies-online antibodies for FOXN2 (54 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FOX: Forkhead boxes

    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry P32314

    ProtoNet protein and cluster: P32314

    UniProtKB/Swiss-Prot: FOXN2_HUMAN, P32314
    Similarity: Contains 1 fork-head DNA-binding domain


    Find genes that share domains with FOXN2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOXN2_HUMAN, P32314
    Function: Binds to the purine-rich region in HTLV-I LTR

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with FOXN2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FOXN2
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    miRNA
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    hsa-mir-183-5p (MIRT047161), hsa-mir-188-5p (MIRT044900), hsa-mir-186-5p (MIRT021206), hsa-mir-100-5p (MIRT048384), hsa-mir-32-5p (MIRT028367), hsa-mir-218-5p (MIRT024223)

    Block miRNA regulation of human, mouse, rat FOXN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FOXN2 (see all 68):
    hsa-miR-140-5p hsa-miR-193a-3p hsa-miR-607 hsa-miR-3146 hsa-miR-300 hsa-miR-188-5p hsa-miR-3613-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidFOXN2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FOXN2_HUMAN, P32314: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with FOXN2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FOXN2
    Interactions:

        Search GeneGlobe Interaction Network for FOXN2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for FOXN2 (P323143 ENSP000003436334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    USP7Q930093, ENSP000003435354I2D: score=1 STRING: ENSP00000343535
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0035914skeletal muscle cell differentiation IEA--

    Find genes that share ontologies with FOXN2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FOXN2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FOXN2 gene: 
    NM_002158.3  

    Unigene Cluster for FOXN2:

    Forkhead box N2
    Hs.468478  [show with all ESTs]
    Unigene Representative Sequence: NM_002158
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000413569 ENST00000340553(uc002rwh.1)
    miRNA
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    hsa-miR-140-5p hsa-miR-193a-3p hsa-miR-607 hsa-miR-3146 hsa-miR-300 hsa-miR-188-5p hsa-miR-3613-3p hsa-miR-200b
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      QuantiTect SYBR Green Assays in human, mouse, rat FOXN2
      QuantiFast Probe-based Assays in human, mouse, rat FOXN2

    Additional mRNA sequence: 

    AK123200.1 BC063305.1 BC069731.1 CR749839.1 U57029.1 

    6 DOTS entries:

    DT.99979329  DT.40272642  DT.100692271  DT.40292197  DT.92420618  DT.92420616 

    Selected AceView cDNA sequences (see all 80):

    NM_002158 AL695313 N46082 BQ025120 BC069731 AA827684 N51765 CR605501 
    AI000803 AA425850 BU683119 AL598357 BC063305 BM926607 BQ025396 BI870278 
    BQ440806 CD643728 CB160709 BQ428805 BX477576 BU675905 BG254670 BX476956 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FOXN2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
    SP1:                                                
    SP2:              -                                 


    ECgene alternative splicing isoforms for FOXN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FOXN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTTCTTTTA
    FOXN2 Expression
    About this image

    FOXN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FOXN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.468478
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FOXN2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Foxn21 , 5 forkhead box N21, 5 84.46(n)1
    84.85(a)1
      17 (57.97 cM)5
    142361  NM_180974.41  NP_851305.21 
     884407115 
    chicken
    (Gallus gallus)
    Aves FOXN21 forkhead box N2 81.71(n)
    88(a)
      421288  NM_001039284.1  NP_001034373.1 
    lizard
    (Anolis carolinensis)
    Reptilia FOXN26
    forkhead box N2
    72(a)
    1 ↔ 1
    1(255368923-255438181)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.347462 Xenopus laevis transcribed sequences 84.54(n)    BJ637907.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003300101 forkhead box protein N2-like 62.83(n)
    64.2(a)
      100330010  XM_002667314.3  XP_002667360.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CHES-1-like6
    Checkpoint suppressor homologue
    11(a)
    1 → many
    X(7576371-7603418)


    ENSEMBL Gene Tree for FOXN2 (if available)
    TreeFam Gene Tree for FOXN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FOXN2 gene
    FOXF12  FOXQ12  FOXN32  FOXJ12  FOXF22  FOXK12  FOXN42  FOXR12  
    FOXH12  FOXK22  FOXN12  FOXJ32  FOXG12  FOXJ22  FOXR22  
    3 SIMAP similar genes for FOXN2 using alignment to 3 protein entries:     FOXN2_HUMAN (see all proteins):
    FOXN4    FOXN3    FOXC1

    Find genes that share paralogs with FOXN2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FOXN2 (see all 1461)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1918391851,2
    --48539839(+) GAAATA/CCTATC 1 -- us2k10--------
    rs1841945071,2
    --48539936(+) GAACCC/TGGGTG 1 -- us2k10--------
    rs1455420131,2
    --48539944(+) GTGGCA/GGAGGT 1 -- us2k10--------
    rs1899928481,2
    --48539971(+) TGCGCC/TACCGC 1 -- us2k10--------
    rs728876491,2
    C--48539974(+) GCCACT/CGCACT 1 -- us2k12Minor allele frequency- C:0.25NA CSA 4
    rs728184941,2
    C--48540314(+) TATGAG/CTGGGC 1 -- us2k13Minor allele frequency- C:0.29NA EA 242
    rs1510100471,2
    --48540485(+) GCAGCA/GTTCCA 1 -- us2k10--------
    rs1822593471,2
    C--48540567(+) ATCAGC/TCCCAC 1 -- us2k10--------
    rs779668621,2
    F--48540649(+) ACACAG/CTGAAC 1 -- us2k11Minor allele frequency- C:0.04NA 120
    rs1855038971,2
    --48540728(+) TATCAC/GTACTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FOXN2 (48541776 - 48606434 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FOXN2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv874002CNV Loss21882294
    nsv874003CNV Loss21882294
    nsv874001CNV Loss21882294
    nsv519831CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 143089    OMIM disorders: --

    2 diseases for FOXN2:    
    About MalaCards
    t-cell leukemia    leukemia


    Find genes that share disorders with FOXN2           About GenesLikeMe

    1 Novoseek inferred disease relationship for FOXN2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 19.6 1 17031231 (1)

    Genetic Association Database (GAD): FOXN2
    Human Genome Epidemiology (HuGE) Navigator: FOXN2 (1 document)

    Export disorders for FOXN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FOXN2 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with FOXN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein HTLF. (PubMed id 1639393)1, 2, 3, 9 Li C.... Gaynor R.B. (Genomics 1992)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. USP7 regulates the stability and function of HLTF through deubiquitination. (PubMed id 21845734)1 Qing P....Ping W.X. (J. Cell. Biochem. 2011)
    4. Aberrant methylation of the CpG island of HLTF gene in gastric cardia adenocarcinoma and dysplasia. (PubMed id 21531217)1 Guo W....Yang Z. (Clin. Biochem. 2011)
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3344 HGNC: 5281 AceView: HTLF Ensembl:ENSG00000170802 euGenes: HUgn3344
    ECgene: FOXN2 H-InvDB: FOXN2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FOXN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FOXN2 gene:
    Search GeneIP for patents involving FOXN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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