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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FOXN2 Gene

protein-coding   GIFtS: 47
GCID: GC02P048541

forkhead box N2

(Previous name: human T-cell leukemia virus enhancer factor )
(Previous symbol: HTLF)
 Explore 11 diseases affiliated with
FOXN2 via our new
 Human Malady Compendium 
Biological research products
for FOXN2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Forkhead Box N21 2
HTLF1 2 3 5
Human T-Cell Leukemia Virus Enhancer Factor1 2 3
Forkhead Box Protein N22

External Ids:    HGNC: 52811   Entrez Gene: 33442   Ensembl: ENSG000001708027   OMIM: 1430895   UniProtKB: P323143   

Export aliases for FOXN2 gene to outside databases

Previous GC identifers: GC02P048395 GC02P048277


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FOXN2:
This gene encodes a forkhead domain binding protein and may function in the transcriptional regulation of the human
T-cell leukemia virus long terminal repeat. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FOXN2_HUMAN, P32314
Function: Binds to the purine-rich region in HTLV-I LTR




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FOXN2 gene promoter:
         FOXO4   FOXO1a   Lmo2   AP-4   FOXO1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOXN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FOXN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22-p16   Ensembl cytogenetic band:  2p16.3   HGNC cytogenetic band: 2p22-p16

FOXN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXN2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P048541:  view genomic region     (about GC identifiers)

Start:
48,541,776 bp from pter      End:
48,606,434 bp from pter
Size:
64,659 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FOXN2_HUMAN, P32314 (See protein sequence)
Recommended Name: Forkhead box protein N2  
Size: 431 amino acids; 47161 Da
Subcellular location: Nucleus
Secondary accessions: Q15769 Q6P4Q2
Alternative splicing: 2 isoforms:  P32314-1   P32314-2   

Explore the universe of human proteins at neXtProt for FOXN2: NX_P32314

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P32314

  • FOXN2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002149.2  
    ENSEMBL proteins: 
     ENSP00000388486   ENSP00000343633  

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    Uscn Proteins for FOXN2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005667transcription factor complex IBA--
    GO:0043231intracellular membrane-bounded organelle IDA--


    FOXN2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    FOXN2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry P32314

    ProtoNet protein and cluster: P32314

    UniProtKB/Swiss-Prot: FOXN2_HUMAN, P32314
    Similarity: Contains 1 fork-head DNA-binding domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: FOXN2_HUMAN, P32314
    Function: Binds to the purine-rich region in HTLV-I LTR

    miRNA
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    hsa-miR-140-5p hsa-miR-193a-3p hsa-miR-607 hsa-miR-3146 hsa-miR-300 hsa-miR-188-5p hsa-miR-3613-3p hsa-miR-200b
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003690double-stranded DNA binding IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS1639393
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IBA--
    GO:0008134transcription factor binding IBA--
    GO:0008301DNA binding, bending IBA--


    FOXN2 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOXN2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for FOXN2 (P323143 ENSP000003436334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    USP7Q930093, ENSP000003435354I2D: score=1 STRING: ENSP00000343535
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent ----
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007389pattern specification process IBA--
    GO:0009790embryo development IBA--
    GO:0009888tissue development IBA--


    FOXN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FOXN2
    Search CenterWatch for drugs/clinical trials and news about FOXN2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FOXN2 gene: 
    NM_002158.3  

    Unigene Cluster for FOXN2:

    Forkhead box N2
    Hs.468478  [show with all ESTs]
    Unigene Representative Sequence: NM_002158
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000413569 ENST00000340553(uc002rwh.1) ENST00000495290

    miRNA
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    8/68 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXN2 (see all 68):
    hsa-miR-140-5p hsa-miR-193a-3p hsa-miR-607 hsa-miR-3146 hsa-miR-300 hsa-miR-188-5p hsa-miR-3613-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidFOXN2 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AK123200.1 BC063305.1 BC069731.1 CR749839.1 U57029.1 

    6 DOTS entries:

    DT.99979329  DT.40272642  DT.100692271  DT.40292197  DT.92420618  DT.92420616 

    24/80 AceView cDNA sequences (see all 80):

    N51765 AI000803 BQ025120 AA425850 AL598357 BC063305 AL695313 CR605501 
    BU683119 AA827684 BC069731 BM926607 NM_002158 N46082 BQ025396 AA366510 
    BU754046 BI870278 BM453913 AL528977 AA913803 BQ440806 BF590117 BU160739 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FOXN2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
    SP1:                                                
    SP2:              -                                 


    ECgene alternative splicing isoforms for FOXN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FOXN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACTTCTTTTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    FOXN2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartRight VentricleHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FOXN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FOXN2

    SOURCE GeneReport for Unigene cluster: Hs.468478
        SABiosciences Custom PCR Arrays for FOXN2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FOXN2 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves FOXN21 forkhead box N2 81.71(n)
    88(a)
      421288  NM_001039284.1  NP_001034373.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    85(a)
    1 ↔ 1
    1(255392511-255393038)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.347462 Xenopus laevis transcribed sequences 84.54(n)    BJ637907.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003300101 forkhead box protein N2-like 62.83(n)
    64.2(a)
      100330010  XM_002667314.2  XP_002667360.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CHES-1-like6
    Checkpoint suppressor homologue
    10(a)
    1 ↔ 1
    X(7576371-7603418)


    ENSEMBL Gene Tree for FOXN2 (if available)
    TreeFam Gene Tree for FOXN2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FOXN2 gene
    FOXJ12  FOXN32  FOXK12  FOXN42  FOXN12  FOXK22  FOXP42  FOXG12  
    FOXJ32  FOXJ22  FOXP22  FOXP32  FOXP12  
    2 SIMAP similar genes for FOXN2 using alignment to 3 protein entries:     FOXN2_HUMAN (see all proteins):
    FOXN3    FOXC1

    FOXN2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1223 NCBI SNPs in FOXN2 are shown (see all 1223    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1918391851,2
    --48539839(+) GAAATA/CCTATC 1 -- us2k10--------
    rs1841945071,2
    --48539936(+) GAACCC/TGGGTG 1 -- us2k10--------
    rs1455420131,2
    --48539944(+) GTGGCA/GGAGGT 1 -- us2k10--------
    rs1899928481,2
    --48539971(+) TGCGCC/TACCGC 1 -- us2k10--------
    rs728876491,2
    C,--48539974(+) GCCACT/CGCACT 1 -- us2k12Minor allele frequency- C:0.25NA CSA 4
    rs728184941,2
    C,--48540314(+) TATGAG/CTGGGC 1 -- us2k13Minor allele frequency- C:0.29NA EA 242
    rs1510100471,2
    --48540485(+) GCAGCA/GTTCCA 1 -- us2k10--------
    rs1822593471,2
    --48540567(+) ATCAGC/TCCCAC 1 -- us2k10--------
    rs779668621,2
    F,--48540649(+) ACACAG/CTGAAC 1 -- us2k11Minor allele frequency- C:0.04NA 120
    rs1855038971,2
    --48540728(+) TATCAC/GTACTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FOXN2 (48541776 - 48606434 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FOXN2: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FOXN2 for disorders           About GeneDecksing

    OMIM gene information: 143089    OMIM disorders: --

    11 diseases for FOXN2:    About MalaCards
    t-cell leukemia    leukemia    gastric cardia adenocarcinoma    adult t-cell leukemia
    sjogren's syndrome    colon cancer    hermaphroditism    hematopoiesis
    colorectal cancer    adenocarcinoma    immunodeficiency

    1 Novoseek disease relationship for FOXN2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 19.6 1 17031231 (1)

    Human Genome Epidemiology (HuGE) Navigator: FOXN2 (1 document)

    Export disorders for FOXN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FOXN2 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with FOXN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein HTLF. (PubMed id 1639393)1, 2, 3, 9 Li C.... Gaynor R.B. (1992)
    2. USP7 regulates the stability and function of HLTF thr ough deubiquitination. (PubMed id 21845734)1 Qing P....Ping W.X. (2011)
    3. Aberrant methylation of the CpG island of HLTF gene i n gastric cardia adenocarcinoma and dysplasia. (PubMed id 21531217)1 Guo W....Yang Z. (2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3344 HGNC: 5281 AceView: HTLF Ensembl:ENSG00000170802 euGenes: HUgn3344
    ECgene: FOXN2 H-InvDB: FOXN2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FOXN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FOXN2 gene:
    Search GeneIP for patents involving FOXN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
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