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Aliases for FOXN2 Gene

Aliases for FOXN2 Gene

  • Forkhead Box N2 2 3 5
  • Human T-Cell Leukemia Virus Enhancer Factor 2 3 4
  • HTLF 3 4

External Ids for FOXN2 Gene

Previous HGNC Symbols for FOXN2 Gene

  • HTLF

Previous GeneCards Identifiers for FOXN2 Gene

  • GC02P048395
  • GC02P048541
  • GC02P048277

Summaries for FOXN2 Gene

Entrez Gene Summary for FOXN2 Gene

  • This gene encodes a forkhead domain binding protein and may function in the transcriptional regulation of the human T-cell leukemia virus long terminal repeat. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXN2 Gene

FOXN2 (Forkhead Box N2) is a Protein Coding gene. Diseases associated with FOXN2 include t-cell leukemia. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is FOXN3.

UniProtKB/Swiss-Prot for FOXN2 Gene

  • Binds to the purine-rich region in HTLV-I LTR.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXN2 Gene

Genomics for FOXN2 Gene

Regulatory Elements for FOXN2 Gene

Enhancers for FOXN2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FOXN2 on UCSC Golden Path with GeneCards custom track

Promoters for FOXN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FOXN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FOXN2 Gene

Chromosome:
2
Start:
48,314,637 bp from pter
End:
48,379,295 bp from pter
Size:
64,659 bases
Orientation:
Plus strand

Genomic View for FOXN2 Gene

Genes around FOXN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXN2 Gene

Proteins for FOXN2 Gene

  • Protein details for FOXN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32314-FOXN2_HUMAN
    Recommended name:
    Forkhead box protein N2
    Protein Accession:
    P32314
    Secondary Accessions:
    • Q15769
    • Q6P4Q2

    Protein attributes for FOXN2 Gene

    Size:
    431 amino acids
    Molecular mass:
    47161 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FOXN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXN2 Gene

Proteomics data for FOXN2 Gene at MOPED

Post-translational modifications for FOXN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXN2 Gene

Domains & Families for FOXN2 Gene

Gene Families for FOXN2 Gene

Protein Domains for FOXN2 Gene

Suggested Antigen Peptide Sequences for FOXN2 Gene

Graphical View of Domain Structure for InterPro Entry

P32314

UniProtKB/Swiss-Prot:

FOXN2_HUMAN :
  • Contains 1 fork-head DNA-binding domain.
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXN2: view

Function for FOXN2 Gene

Molecular function for FOXN2 Gene

UniProtKB/Swiss-Prot Function:
Binds to the purine-rich region in HTLV-I LTR.

Gene Ontology (GO) - Molecular Function for FOXN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25609649
genes like me logo Genes that share ontologies with FOXN2: view

Phenotypes for FOXN2 Gene

genes like me logo Genes that share phenotypes with FOXN2: view

Animal Model Products

miRNA for FOXN2 Gene

miRTarBase miRNAs that target FOXN2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FOXN2 Gene

Localization for FOXN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXN2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXN2 Gene COMPARTMENTS Subcellular localization image for FOXN2 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for FOXN2 Gene

Pathways & Interactions for FOXN2 Gene

SuperPathways for FOXN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035914 skeletal muscle cell differentiation IEA --
genes like me logo Genes that share ontologies with FOXN2: view

No data available for Pathways by source and SIGNOR curated interactions for FOXN2 Gene

Drugs & Compounds for FOXN2 Gene

No Compound Related Data Available

Transcripts for FOXN2 Gene

Unigene Clusters for FOXN2 Gene

Forkhead box N2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXN2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: -

Relevant External Links for FOXN2 Gene

GeneLoc Exon Structure for
FOXN2
ECgene alternative splicing isoforms for
FOXN2

Expression for FOXN2 Gene

mRNA expression in normal human tissues for FOXN2 Gene

Protein differential expression in normal tissues from HIPED for FOXN2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FOXN2 Gene



SOURCE GeneReport for Unigene cluster for FOXN2 Gene Hs.468478

genes like me logo Genes that share expression patterns with FOXN2: view

Protein tissue co-expression partners for FOXN2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FOXN2 Gene

Orthologs for FOXN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXN2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOXN2 35
  • 93.12 (n)
  • 93.04 (a)
FOXN2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXN2 35
  • 93.97 (n)
  • 94.2 (a)
FOXN2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxn2 35
  • 84.46 (n)
  • 84.85 (a)
Foxn2 16
Foxn2 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FOXN2 35
  • 99.77 (n)
  • 100 (a)
FOXN2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxn2 35
  • 84.58 (n)
  • 84.35 (a)
oppossum
(Monodelphis domestica)
Mammalia FOXN2 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOXN2 35
  • 81.71 (n)
  • 88 (a)
FOXN2 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXN2 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia foxn2 35
  • 74.97 (n)
  • 80.26 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.34746 35
zebrafish
(Danio rerio)
Actinopterygii LOC100330010 35
  • 62.83 (n)
  • 64.2 (a)
CABZ01056728.1 36
  • 53 (a)
OneToMany
foxn2b 36
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CHES-1-like 36
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5413 36
  • 20 (a)
OneToMany
Species with no ortholog for FOXN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXN2 Gene

ENSEMBL:
Gene Tree for FOXN2 (if available)
TreeFam:
Gene Tree for FOXN2 (if available)

Paralogs for FOXN2 Gene

Paralogs for FOXN2 Gene

(3) SIMAP similar genes for FOXN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FOXN2: view

Variants for FOXN2 Gene

Sequence variations from dbSNP and Humsavar for FOXN2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs3207914 -- 48,317,888(-) ggttc(A/C)cgcct intron-variant
rs5830991 -- 48,334,483(+) AAACA(-/TC)TGTTT intron-variant
rs1132623 -- 48,378,633(+) ATTTA(C/T)CTAAG utr-variant-3-prime
rs6755999 -- 48,358,588(+) TACCT(G/T)GAAAA intron-variant
rs9309152 -- 48,336,202(+) AGTTC(A/G)AGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOXN2 Gene

Variant ID Type Subtype PubMed ID
nsv519831 CNV Gain 19592680
nsv874001 CNV Loss 21882294
nsv874002 CNV Loss 21882294
nsv874003 CNV Loss 21882294

Variation tolerance for FOXN2 Gene

Residual Variation Intolerance Score: 12.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXN2 Gene

HapMap Linkage Disequilibrium report
FOXN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXN2 Gene

Disorders for FOXN2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FOXN2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
t-cell leukemia
  • leukemia t-cell
- elite association - COSMIC cancer census association via MalaCards
Search FOXN2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FOXN2

Genetic Association Database (GAD)
FOXN2
Human Genome Epidemiology (HuGE) Navigator
FOXN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXN2
genes like me logo Genes that share disorders with FOXN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOXN2 Gene

Publications for FOXN2 Gene

  1. Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein HTLF. (PMID: 1639393) Li C. … Gaynor R.B. (Genomics 1992) 2 3 4 23 67
  2. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  4. Aberrant methylation of the CpG island of HLTF gene in gastric cardia adenocarcinoma and dysplasia. (PMID: 21531217) Guo W. … Yang Z. (Clin. Biochem. 2011) 3
  5. USP7 regulates the stability and function of HLTF through deubiquitination. (PMID: 21845734) Qing P. … Ping W.X. (J. Cell. Biochem. 2011) 3

Products for FOXN2 Gene

Sources for FOXN2 Gene

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