Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FOXN2 Gene

protein-coding   GIFtS: 48
GCID: GC02P048541

Forkhead Box N2

(Previous name: human T-cell leukemia virus enhancer factor)
(Previous symbol: HTLF)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Forkhead Box N21 2
HTLF1 2 3 5
Human T-Cell Leukemia Virus Enhancer Factor1 2 3
Forkhead Box Protein N22

External Ids:    HGNC: 52811   Entrez Gene: 33442   Ensembl: ENSG000001708027   OMIM: 1430895   UniProtKB: P323143   

Export aliases for FOXN2 gene to outside databases

Previous GC identifers: GC02P048395 GC02P048277


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FOXN2 Gene:
This gene encodes a forkhead domain binding protein and may function in the transcriptional regulation of the
human T-cell leukemia virus long terminal repeat. (provided by RefSeq, Jul 2008)

GeneCards Summary for FOXN2 Gene: 
FOXN2 (forkhead box N2) is a protein-coding gene. Diseases associated with FOXN2 include t-cell leukemia, and gastric cardia adenocarcinoma. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOXN3.

UniProtKB/Swiss-Prot: FOXN2_HUMAN, P32314
Function: Binds to the purine-rich region in HTLV-I LTR




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FOXN2 gene promoter:
         FOXO4   FOXO1a   Lmo2   AP-4   FOXO1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOXN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FOXN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22-p16   Ensembl cytogenetic band:  2p16.3   HGNC cytogenetic band: 2p22-p16

FOXN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXN2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P048541:  view genomic region     (about GC identifiers)

Start:
48,541,776 bp from pter      End:
48,606,434 bp from pter
Size:
64,659 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FOXN2_HUMAN, P32314 (See protein sequence)
Recommended Name: Forkhead box protein N2  
Size: 431 amino acids; 47161 Da
Subcellular location: Nucleus
Secondary accessions: Q15769 Q6P4Q2
Alternative splicing: 2 isoforms:  P32314-1   P32314-2   

Explore the universe of human proteins at neXtProt for FOXN2: NX_P32314

Explore proteomics data for FOXN2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P32314

  • FOXN2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FOXN2 Protein Expression
    REFSEQ proteins: NP_002149.2  
    ENSEMBL proteins: 
     ENSP00000388486   ENSP00000343633  

    Human Recombinant Protein Products for FOXN2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for FOXN2
    OriGene Protein Over-expression Lysate for FOXN2
    OriGene MassSpec for FOXN2 
    OriGene Custom Protein Services for FOXN2
    GenScript Custom Purified and Recombinant Proteins Services for FOXN2
    Novus Biologicals FOXN2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FOXN2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005667transcription factor complex ----
    GO:0043231intracellular membrane-bounded organelle IDA--

    FOXN2 for ontologies           About GeneDecksing



    FOXN2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FOXN2
    GenScript Custom Superior Antibodies Services for FOXN2
    Novus Biologicals FOXN2 Antibodies
    Abcam antibodies for FOXN2
    Cloud-Clone Corp. Antibodies for FOXN2 
    Search ThermoFisher Antibodies for FOXN2
    LSBio Antibodies in human, mouse, rat for FOXN2 

    Assay Products for FOXN2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FOXN2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FOXN2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FOXN2 
    Cloud-Clone Corp. CLIAs for FOXN2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FOX: Forkhead boxes

    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry P32314

    ProtoNet protein and cluster: P32314

    UniProtKB/Swiss-Prot: FOXN2_HUMAN, P32314
    Similarity: Contains 1 fork-head DNA-binding domain


    FOXN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOXN2_HUMAN, P32314
    Function: Binds to the purine-rich region in HTLV-I LTR

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003690double-stranded DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity ----
    GO:0008134transcription factor binding ----
    GO:0008301DNA binding, bending ----
         
    FOXN2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FOXN2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FOXN2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FOXN2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FOXN2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOXN2
    8/68 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXN2 (see all 68):
    hsa-miR-140-5p hsa-miR-193a-3p hsa-miR-607 hsa-miR-3146 hsa-miR-300 hsa-miR-188-5p hsa-miR-3613-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidFOXN2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FOXN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXN2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FOXN2
    Sirion Biotech Customized adenovirus for overexpression of FOXN2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for FOXN2 (see all 7)
    OriGene ORF clones in mouse, rat for FOXN2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FOXN2 (NM_002158)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXN2
    Sirion Biotech Customized lentivirus for stable overexpression of FOXN2 
                         Customized lentivirus expression plasmids for stable overexpression of FOXN2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FOXN2
    Search LifeMap BioReagents cell lines for FOXN2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXN2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOXN2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for FOXN2 (P323143 ENSP000003436334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    USP7Q930093, ENSP000003435354I2D: score=1 STRING: ENSP00000343535
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007389pattern specification process ----
    GO:0009790embryo development ----
    GO:0009888tissue development ----

    FOXN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FOXN2

    Search CenterWatch for drugs/clinical trials and news about FOXN2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FOXN2 gene: 
    NM_002158.3  

    Unigene Cluster for FOXN2:

    Forkhead box N2
    Hs.468478  [show with all ESTs]
    Unigene Representative Sequence: NM_002158
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000413569 ENST00000340553(uc002rwh.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOXN2
    8/68 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXN2 (see all 68):
    hsa-miR-140-5p hsa-miR-193a-3p hsa-miR-607 hsa-miR-3146 hsa-miR-300 hsa-miR-188-5p hsa-miR-3613-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidFOXN2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FOXN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXN2
    Clone
    Products:
         
    OriGene clones in human, mouse for FOXN2 (see all 7)
    OriGene ORF clones in mouse, rat for FOXN2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FOXN2 (NM_002158)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXN2
    Sirion Biotech Customized lentivirus for stable overexpression of FOXN2 
                         Customized lentivirus expression plasmids for stable overexpression of FOXN2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FOXN2
    OriGene qSTAR qPCR primer pairs in human, mouse for FOXN2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FOXN2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXN2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXN2

    Additional mRNA sequence: 

    AK123200.1 BC063305.1 BC069731.1 CR749839.1 U57029.1 

    6 DOTS entries:

    DT.99979329  DT.40272642  DT.100692271  DT.40292197  DT.92420618  DT.92420616 

    24/80 AceView cDNA sequences (see all 80):

    BQ025120 BU683119 N46082 BQ025396 N51765 NM_002158 BM926607 AI000803 
    AL598357 BC069731 AL695313 AA827684 CR605501 AA425850 BC063305 R76660 
    BU160739 AA366510 BQ428805 CB990103 BU754046 BM747405 CK003872 BX494321 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FOXN2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
    SP1:                                                
    SP2:              -                                 


    ECgene alternative splicing isoforms for FOXN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FOXN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTTCTTTTA
    FOXN2 Expression
    About this image


    See FOXN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FOXN2

    SOURCE GeneReport for Unigene cluster: Hs.468478
        SABiosciences Custom PCR Arrays for FOXN2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FOXN2
    OriGene qSTAR qPCR primer pairs in human, mouse for FOXN2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FOXN2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXN2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXN2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FOXN2 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Foxn21 , 5 forkhead box N21, 5 84.54(n)1
    84.85(a)1
      17 (57.97 cM)5
    142361  NM_180974.41  NP_851305.21 
     884407115 
    chicken
    (Gallus gallus)
    Aves FOXN21 forkhead box N2 81.71(n)
    88(a)
      421288  NM_001039284.1  NP_001034373.1 
    lizard
    (Anolis carolinensis)
    Reptilia FOXN26
    forkhead box N2
    72(a)
    1 ↔ 1
    1(255368923-255438181)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.347462 Xenopus laevis transcribed sequences 84.54(n)    BJ637907.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003300101 forkhead box protein N2-like 62.83(n)
    64.2(a)
      100330010  XM_002667314.2  XP_002667360.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CHES-1-like6
    Checkpoint suppressor homologue
    10(a)
    1 → many
    X(7576371-7603418)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FHL16
    Regulator of ribosomal protein transcription; has ...
    6(a)
    1 → many
    XVI(733623-736433)


    ENSEMBL Gene Tree for FOXN2 (if available)
    TreeFam Gene Tree for FOXN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FOXN2 gene
    FOXN32  FOXJ12  FOXK12  FOXN42  FOXK22  FOXP42  FOXN12  FOXG12  
    FOXJ32  FOXP22  FOXJ22  FOXP32  FOXP12  
    2 SIMAP similar genes for FOXN2 using alignment to 3 protein entries:     FOXN2_HUMAN (see all proteins):
    FOXN3    FOXC1

    FOXN2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1461 SNPs in FOXN2 are shown (see all 1461)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1918391851,2
    --48539839(+) GAAATA/CCTATC 1 -- us2k10--------
    rs1841945071,2
    --48539936(+) GAACCC/TGGGTG 1 -- us2k10--------
    rs1455420131,2
    --48539944(+) GTGGCA/GGAGGT 1 -- us2k10--------
    rs1899928481,2
    --48539971(+) TGCGCC/TACCGC 1 -- us2k10--------
    rs728876491,2
    C--48539974(+) GCCACT/CGCACT 1 -- us2k12Minor allele frequency- C:0.25NA CSA 4
    rs728184941,2
    C--48540314(+) TATGAG/CTGGGC 1 -- us2k13Minor allele frequency- C:0.29NA EA 242
    rs1510100471,2
    --48540485(+) GCAGCA/GTTCCA 1 -- us2k10--------
    rs1822593471,2
    C--48540567(+) ATCAGC/TCCCAC 1 -- us2k10--------
    rs779668621,2
    F--48540649(+) ACACAG/CTGAAC 1 -- us2k11Minor allele frequency- C:0.04NA 120
    rs1855038971,2
    --48540728(+) TATCAC/GTACTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FOXN2 (48541776 - 48606434 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FOXN2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv874002CNV Loss21882294
    nsv874003CNV Loss21882294
    nsv874001CNV Loss21882294
    nsv519831CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FOXN2
    DNA2.0 Custom Variant and Variant Library Synthesis for FOXN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 143089    OMIM disorders: --

    9 diseases for FOXN2:    About MalaCards
    t-cell leukemia    gastric cardia adenocarcinoma    leukemia    adult t-cell leukemia
    sjogren's syndrome    colon cancer    adenocarcinoma    colorectal cancer
    endotheliitis


    FOXN2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for FOXN2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 19.6 1 17031231 (1)

    Genetic Association Database (GAD): FOXN2
    Human Genome Epidemiology (HuGE) Navigator: FOXN2 (1 document)

    Export disorders for FOXN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FOXN2 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with FOXN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein HTLF. (PubMed id 1639393)1, 2, 3, 9 Li C.... Gaynor R.B. (1992)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. USP7 regulates the stability and function of HLTF thr ough deubiquitination. (PubMed id 21845734)1 Qing P....Ping W.X. (2011)
    4. Aberrant methylation of the CpG island of HLTF gene i n gastric cardia adenocarcinoma and dysplasia. (PubMed id 21531217)1 Guo W....Yang Z. (2011)
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3344 HGNC: 5281 AceView: HTLF Ensembl:ENSG00000170802 euGenes: HUgn3344
    ECgene: FOXN2 H-InvDB: FOXN2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FOXN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FOXN2 gene:
    Search GeneIP for patents involving FOXN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FOXN2  
     OriGene qPCR primer pairs and template standards for FOXN2   OriGene Protein Over-expression Lysate for FOXN2  
     OriGene MassSpec something-or-other for FOXN2   OriGene clones in human, mouse for FOXN2  
     OriGene qSTAR qPCR primer pairs in human, mouse for FOXN2   OriGene Purified Protein for FOXN2  
     OriGene ORF clones in mouse, rat for FOXN2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FOXN2   OriGene Custom Protein Services for FOXN2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FOXN2
     QIAGEN SeqTarget long-range PCR primers for resequencing FOXN2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXN2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXN2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXN2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXN2
     GenScript Custom Purified and Recombinant Proteins Services for FOXN2 GenScript cDNA clones with any tag delivered in your preferred vector for FOXN2
     GenScript Custom Assay Services for FOXN2 GenScript Custom Superior Antibodies Services for FOXN2
     GenScript Custom overexpressing Cell Line Services for FOXN2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FOXN2 promoter
     Search Chromatin IP Primers for FOXN2
     RT2 qPCR Primer Assay in human, mouse, rat FOXN2
     Search GNC Networks for FOXN2
     SABiosciences Custom PCR Arrays for FOXN2
     Search Tocris compounds for FOXN2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FOXN2 antibodies
     FOXN2 lysates
     Antibodies for FOXN2
     See all of Abcam's Antibodies, Kits and Proteins for FOXN2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for FOXN2
     Antibodies for FOXN2
     ELISAs for FOXN2
     CLIAs for FOXN2
     Search LifeMap BioReagents cell lines for FOXN2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXN2
     SwitchGear 3'UTR luciferase reporter plasmids for FOXN2
     SwitchGear Promoter luciferase reporter plasmids for FOXN2
     Search ThermoFisher Antibodies for FOXN2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXN2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for FOXN2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FOXN2
    Customized:
     lentivirus for stable overexpression of FOXN2
     lentivirus expression plasmids for stable overexpression of FOXN2
     adenovirus for overexpression of FOXN2
     LSBio Antibodies in human, mouse, rat for FOXN2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FOXN2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4