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Aliases for FOXN2 Gene

Aliases for FOXN2 Gene

  • Forkhead Box N2 2 3 5
  • Human T-Cell Leukemia Virus Enhancer Factor 2 3 4
  • HTLF 3 4
  • Forkhead Box Protein N2 3

External Ids for FOXN2 Gene

Previous HGNC Symbols for FOXN2 Gene

  • HTLF

Previous GeneCards Identifiers for FOXN2 Gene

  • GC02P048395
  • GC02P048541
  • GC02P048277

Summaries for FOXN2 Gene

Entrez Gene Summary for FOXN2 Gene

  • This gene encodes a forkhead domain binding protein and may function in the transcriptional regulation of the human T-cell leukemia virus long terminal repeat. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXN2 Gene

FOXN2 (Forkhead Box N2) is a Protein Coding gene. Diseases associated with FOXN2 include T-Cell Leukemia. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is FOXN3.

UniProtKB/Swiss-Prot for FOXN2 Gene

  • Binds to the purine-rich region in HTLV-I LTR.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXN2 Gene

Genomics for FOXN2 Gene

Regulatory Elements for FOXN2 Gene

Enhancers for FOXN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F048405 0.5 ENCODE 53.8 +92.1 92093 1.5 TAL1 ARID1B FOSL1 NCOR1 KLF16 KDM1A TRIM24 CREM FOXN2 PPP1R21 GTF2A1L GC02M048388 ENSG00000272663
GH02F048323 1.5 FANTOM5 Ensembl ENCODE 47.5 +13.7 13664 9.8 SOX13 PKNOX1 CBX3 ARID4B FEZF1 RFX5 CHAMP1 POLR2A SCRT2 PRDM10 FOXN2 PPP1R21 FBXO11 LOC100506235 GTF2A1L STON1 GC02M048341 GC02P048318 RNU4-49P
GH02F048342 1 ENCODE 47.4 +30.2 30238 4.4 PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 FOS SP5 FOXN2 PPP1R21 GTF2A1L RNU4-49P GC02M048341 GC02M048365
GH02F048478 0.6 ENCODE 34.6 +165.6 165558 2.6 CTCF FOXA3 ZNF644 FOXA1 ZFHX2 FOXK2 SMARCA4 SCRT2 GABPB1 ZBTB33 PPP1R21 FOXN2 RNU6-282P STON1 STON1-GTF2A1L GC02M048450 GC02M048502
GH02F048042 0.5 ENCODE 32.5 -270.9 -270865 2.1 ELF3 ATF1 ARID4B RAD21 ZSCAN9 ZNF48 RARA SLC30A9 GATA4 CREM FOXN2 GTF2A1L PPP1R21 GC02M048066 LOC105374591
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FOXN2 on UCSC Golden Path with GeneCards custom track

Promoters for FOXN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000301105 663 3801 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 CBX5

Genomic Location for FOXN2 Gene

Chromosome:
2
Start:
48,314,637 bp from pter
End:
48,379,295 bp from pter
Size:
64,659 bases
Orientation:
Plus strand

Genomic View for FOXN2 Gene

Genes around FOXN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXN2 Gene

Proteins for FOXN2 Gene

  • Protein details for FOXN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32314-FOXN2_HUMAN
    Recommended name:
    Forkhead box protein N2
    Protein Accession:
    P32314
    Secondary Accessions:
    • Q15769
    • Q6P4Q2

    Protein attributes for FOXN2 Gene

    Size:
    431 amino acids
    Molecular mass:
    47161 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FOXN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXN2 Gene

Post-translational modifications for FOXN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FOXN2 Gene

Domains & Families for FOXN2 Gene

Gene Families for FOXN2 Gene

Protein Domains for FOXN2 Gene

Suggested Antigen Peptide Sequences for FOXN2 Gene

Graphical View of Domain Structure for InterPro Entry

P32314

UniProtKB/Swiss-Prot:

FOXN2_HUMAN :
  • Contains 1 fork-head DNA-binding domain.
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXN2: view

Function for FOXN2 Gene

Molecular function for FOXN2 Gene

UniProtKB/Swiss-Prot Function:
Binds to the purine-rich region in HTLV-I LTR.

Gene Ontology (GO) - Molecular Function for FOXN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 25609649
GO:0043565 sequence-specific DNA binding IEA,IBA --
genes like me logo Genes that share ontologies with FOXN2: view
genes like me logo Genes that share phenotypes with FOXN2: view

Animal Model Products

miRNA for FOXN2 Gene

miRTarBase miRNAs that target FOXN2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FOXN2 Gene

Localization for FOXN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXN2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXN2 Gene COMPARTMENTS Subcellular localization image for FOXN2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for FOXN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with FOXN2: view

Pathways & Interactions for FOXN2 Gene

SuperPathways for FOXN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030154 cell differentiation IBA --
GO:0035914 skeletal muscle cell differentiation IEA --
GO:0045893 positive regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with FOXN2: view

No data available for Pathways by source and SIGNOR curated interactions for FOXN2 Gene

Transcripts for FOXN2 Gene

Unigene Clusters for FOXN2 Gene

Forkhead box N2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXN2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: -

Relevant External Links for FOXN2 Gene

GeneLoc Exon Structure for
FOXN2
ECgene alternative splicing isoforms for
FOXN2

Expression for FOXN2 Gene

mRNA expression in normal human tissues for FOXN2 Gene

Protein differential expression in normal tissues from HIPED for FOXN2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FOXN2 Gene



Protein tissue co-expression partners for FOXN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FOXN2 Gene:

FOXN2

SOURCE GeneReport for Unigene cluster for FOXN2 Gene:

Hs.468478
genes like me logo Genes that share expression patterns with FOXN2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FOXN2 Gene

Orthologs for FOXN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXN2 34 35
  • 99.77 (n)
dog
(Canis familiaris)
Mammalia FOXN2 34 35
  • 93.97 (n)
cow
(Bos Taurus)
Mammalia FOXN2 34 35
  • 93.12 (n)
oppossum
(Monodelphis domestica)
Mammalia FOXN2 35
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxn2 34
  • 84.58 (n)
mouse
(Mus musculus)
Mammalia Foxn2 34 16 35
  • 84.46 (n)
chicken
(Gallus gallus)
Aves FOXN2 34 35
  • 81.71 (n)
lizard
(Anolis carolinensis)
Reptilia FOXN2 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia foxn2 34
  • 74.97 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.34746 34
zebrafish
(Danio rerio)
Actinopterygii LOC100330010 34
  • 62.83 (n)
CABZ01056728.1 35
  • 53 (a)
OneToMany
foxn2b 35
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CHES-1-like 35
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5413 35
  • 20 (a)
OneToMany
Species where no ortholog for FOXN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXN2 Gene

ENSEMBL:
Gene Tree for FOXN2 (if available)
TreeFam:
Gene Tree for FOXN2 (if available)

Paralogs for FOXN2 Gene

Paralogs for FOXN2 Gene

(3) SIMAP similar genes for FOXN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FOXN2: view

Variants for FOXN2 Gene

Sequence variations from dbSNP and Humsavar for FOXN2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10153644 -- 48,336,429(+) TATAt(A/G)tgtat intron-variant
rs10153773 -- 48,338,892(+) tctta(C/T)taaaa intron-variant
rs10167097 -- 48,361,859(+) CATAC(C/G)TGTTT intron-variant
rs10174717 -- 48,323,631(+) tagtc(C/G)tttgt intron-variant
rs10176639 -- 48,329,365(+) TTTTT(C/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOXN2 Gene

Variant ID Type Subtype PubMed ID
esv2762252 CNV gain 21179565
nsv519831 CNV gain 19592680
nsv953781 CNV duplication 24416366

Variation tolerance for FOXN2 Gene

Residual Variation Intolerance Score: 12.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXN2 Gene

Disorders for FOXN2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FOXN2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
t-cell leukemia
  • leukemia t-cell
- elite association - COSMIC cancer census association via MalaCards
Search FOXN2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FOXN2

Genetic Association Database (GAD)
FOXN2
Human Genome Epidemiology (HuGE) Navigator
FOXN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXN2
genes like me logo Genes that share disorders with FOXN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOXN2 Gene

Publications for FOXN2 Gene

  1. Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein HTLF. (PMID: 1639393) Li C. … Gaynor R.B. (Genomics 1992) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3 64
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64
  5. Aberrant methylation of the CpG island of HLTF gene in gastric cardia adenocarcinoma and dysplasia. (PMID: 21531217) Guo W. … Yang Z. (Clin. Biochem. 2011) 3 64

Products for FOXN2 Gene

Sources for FOXN2 Gene

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