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Aliases for FOXN2 Gene

Aliases for FOXN2 Gene

  • Forkhead Box N2 2 3
  • Human T-Cell Leukemia Virus Enhancer Factor 2 3 4
  • HTLF 3 4 6
  • Forkhead Box Protein N2 3

External Ids for FOXN2 Gene

Previous HGNC Symbols for FOXN2 Gene

  • HTLF

Previous GeneCards Identifiers for FOXN2 Gene

  • GC02P048395
  • GC02P048541
  • GC02P048277

Summaries for FOXN2 Gene

Entrez Gene Summary for FOXN2 Gene

  • This gene encodes a forkhead domain binding protein and may function in the transcriptional regulation of the human T-cell leukemia virus long terminal repeat. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXN2 Gene

FOXN2 (Forkhead Box N2) is a Protein Coding gene. Diseases associated with FOXN2 include t-cell leukemia and leukemia. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is FOXK2.

UniProtKB/Swiss-Prot for FOXN2 Gene

  • Binds to the purine-rich region in HTLV-I LTR

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXN2 Gene

Genomics for FOXN2 Gene

Regulatory Elements for FOXN2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FOXN2 Gene

Start:
48,314,637 bp from pter
End:
48,379,295 bp from pter
Size:
64,659 bases
Orientation:
Plus strand

Genomic View for FOXN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXN2 Gene

Proteins for FOXN2 Gene

  • Protein details for FOXN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32314-FOXN2_HUMAN
    Recommended name:
    Forkhead box protein N2
    Protein Accession:
    P32314
    Secondary Accessions:
    • Q15769
    • Q6P4Q2

    Protein attributes for FOXN2 Gene

    Size:
    431 amino acids
    Molecular mass:
    47161 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FOXN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXN2 Gene

Proteomics data for FOXN2 Gene at MOPED

Post-translational modifications for FOXN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXN2 Gene

Domains for FOXN2 Gene

Gene Families for FOXN2 Gene

HGNC:
  • FOX :Forkhead boxes

Protein Domains for FOXN2 Gene

Suggested Antigen Peptide Sequences for FOXN2 Gene

Graphical View of Domain Structure for InterPro Entry

P32314

UniProtKB/Swiss-Prot:

FOXN2_HUMAN :
  • P32314
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXN2: view

Function for FOXN2 Gene

Molecular function for FOXN2 Gene

UniProtKB/Swiss-Prot Function: Binds to the purine-rich region in HTLV-I LTR

Gene Ontology (GO) - Molecular Function for FOXN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXN2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOXN2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FOXN2 Gene

Localization for FOXN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXN2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXN2 Gene COMPARTMENTS Subcellular localization image for FOXN2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for FOXN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with FOXN2: view

Pathways for FOXN2 Gene

SuperPathways for FOXN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0035914 skeletal muscle cell differentiation IEA --
genes like me logo Genes that share ontologies with FOXN2: view

No data available for Pathways by source for FOXN2 Gene

Transcripts for FOXN2 Gene

Unigene Clusters for FOXN2 Gene

Forkhead box N2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOXN2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXN2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: -

Relevant External Links for FOXN2 Gene

GeneLoc Exon Structure for
FOXN2
ECgene alternative splicing isoforms for
FOXN2

Expression for FOXN2 Gene

mRNA expression in normal human tissues for FOXN2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FOXN2 Gene

SOURCE GeneReport for Unigene cluster for FOXN2 Gene Hs.468478

genes like me logo Genes that share expressions with FOXN2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FOXN2 Gene

Orthologs for FOXN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXN2 35
  • 99.77 (n)
  • 100 (a)
FOXN2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FOXN2 35
  • 93.12 (n)
  • 93.04 (a)
FOXN2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXN2 35
  • 93.97 (n)
  • 94.2 (a)
FOXN2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxn2 35
  • 84.46 (n)
  • 84.85 (a)
Foxn2 16
Foxn2 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FOXN2 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxn2 35
  • 84.58 (n)
  • 84.35 (a)
chicken
(Gallus gallus)
Aves FOXN2 35
  • 81.71 (n)
  • 88 (a)
FOXN2 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXN2 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.34746 35
tropical clawed frog
(Silurana tropicalis)
Amphibia foxn2 35
  • 74.97 (n)
  • 80.26 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01056728.1 36
  • 53 (a)
OneToMany
foxn2b 36
  • 51 (a)
OneToMany
LOC100330010 35
  • 62.83 (n)
  • 64.2 (a)
fruit fly
(Drosophila melanogaster)
Insecta CHES-1-like 36
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5413 36
  • 20 (a)
OneToMany
Species with no ortholog for FOXN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXN2 Gene

ENSEMBL:
Gene Tree for FOXN2 (if available)
TreeFam:
Gene Tree for FOXN2 (if available)

Paralogs for FOXN2 Gene

Selected SIMAP similar genes for FOXN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FOXN2: view

Variants for FOXN2 Gene

Sequence variations from dbSNP and Humsavar for FOXN2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1132623 -- 48,378,633(+) ATTTA(C/T)CTAAG utr-variant-3-prime
rs3207914 -- 48,317,888(-) ggttc(A/C)cgcct intron-variant
rs4132143 -- 48,378,638(+) TCTAA(A/G)AAACT utr-variant-3-prime
rs4290706 -- 48,313,905(+) TGAGC(A/T)CTCCT upstream-variant-2KB
rs4328683 -- 48,363,131(+) agctc(C/T)ctgtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOXN2 Gene

Variant ID Type Subtype PubMed ID
nsv519831 CNV Gain 19592680
nsv874001 CNV Loss 21882294
nsv874002 CNV Loss 21882294
nsv874003 CNV Loss 21882294

Relevant External Links for FOXN2 Gene

HapMap Linkage Disequilibrium report
FOXN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXN2 Gene

Disorders for FOXN2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for FOXN2 Gene including...

Search for FOXN2 Gene in MalaCards »

(1) Novoseek inferred disease relationships for FOXN2 Gene

Disease -log(P) Hits PubMed IDs
colon cancer 19.6 1

Relevant External Links for FOXN2

Genetic Association Database (GAD)
FOXN2
Human Genome Epidemiology (HuGE) Navigator
FOXN2
genes like me logo Genes that share disorders with FOXN2: view

No data available for UniProtKB/Swiss-Prot for FOXN2 Gene

Publications for FOXN2 Gene

  1. Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein HTLF. (PMID: 1639393) Li C. … Gaynor R.B. (Genomics 1992) 2 3 4 23
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Aberrant methylation of the CpG island of HLTF gene in gastric cardia adenocarcinoma and dysplasia. (PMID: 21531217) Guo W. … Yang Z. (Clin. Biochem. 2011) 3
  4. USP7 regulates the stability and function of HLTF through deubiquitination. (PMID: 21845734) Qing P. … Ping W.X. (J. Cell. Biochem. 2011) 3
  5. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3

Products for FOXN2 Gene

Sources for FOXN2 Gene

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