Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FOXN1 Gene

protein-coding   GIFtS: 53
GCID: GC17P026850

Forkhead Box N1

(Previous names: winged-helix nude, Rowett nude)
(Previous symbols: WHN, RONU)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Forkhead Box N11 2     Winged-Helix Transcription Factor Nude2 3
WHN1 2 3 5     FKHL202
RONU1 2 3     Forkhead Box Protein N12
Rowett Nude1 2     Winged Helix Nude2
Winged-Helix Nude1 2     

External Ids:    HGNC: 127651   Entrez Gene: 84562   Ensembl: ENSG000001091017   OMIM: 6008385   UniProtKB: O153533   

Export aliases for FOXN1 gene to outside databases

Previous GC identifers: GC17P026702 GC17P026996 GC17P023875 GC17P023059


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FOXN1 Gene:
Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic
phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is
orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to
regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the
skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been
observed. (provided by RefSeq, Jul 2008)

GeneCards Summary for FOXN1 Gene: 
FOXN1 (forkhead box N1) is a protein-coding gene. Diseases associated with FOXN1 include thymic epithelial neoplasm, and t-cell immunodeficiency, congenital alopecia and nail dystrophy. GO annotations related to this gene include double-stranded DNA binding and sequence-specific DNA binding. An important paralog of this gene is FOXN3.

UniProtKB/Swiss-Prot: FOXN1_HUMAN, O15353
Function: Transcriptional regulator involved in development

Gene Wiki entry for FOXN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010799.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FOXN1 gene promoter:
         Max1   SRF   SRF (504 AA)   Olf-1   Nkx2-5   NF-kappaB   AREB6   NF-kappaB1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOXN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FOXN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11-q12   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11-q12

FOXN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXN1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P026850:  view genomic region     (about GC identifiers)

Start:
26,833,261 bp from pter      End:
26,865,914 bp from pter
Size:
32,654 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FOXN1_HUMAN, O15353 (See protein sequence)
Recommended Name: Forkhead box protein N1  
Size: 648 amino acids; 68925 Da
Subcellular location: Nucleus
Secondary accessions: B2R9Q7 O15352

Explore the universe of human proteins at neXtProt for FOXN1: NX_O15353

Explore proteomics data for FOXN1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15353

  • FOXN1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FOXN1 Protein Expression
    REFSEQ proteins: NP_003584.2  
    ENSEMBL proteins: 
     ENSP00000462159   ENSP00000464645   ENSP00000226247  

    Human Recombinant Protein Products for FOXN1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FOXN1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for FOXN1
    GenScript Custom Purified and Recombinant Proteins Services for FOXN1
    Novus Biologicals FOXN1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FOXN1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex IBA--

    FOXN1 for ontologies           About GeneDecksing



    FOXN1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for FOXN1
    OriGene Antibodies for FOXN1
    OriGene Custom Antibody Services for FOXN1
    GenScript Custom Superior Antibodies Services for FOXN1
    Novus Biologicals FOXN1 Antibodies
    Abcam antibodies for FOXN1
    Cloud-Clone Corp. Antibodies for FOXN1 
    ThermoFisher Antibodies for FOXN1
    LSBio Antibodies in human, mouse, rat for FOXN1 

    Assay Products for FOXN1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FOXN1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FOXN1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FOXN1 
    Cloud-Clone Corp. CLIAs for FOXN1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FOX: Forkhead boxes

    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry O15353

    ProtoNet protein and cluster: O15353

    UniProtKB/Swiss-Prot: FOXN1_HUMAN, O15353
    Similarity: Contains 1 fork-head DNA-binding domain


    FOXN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOXN1_HUMAN, O15353
    Function: Transcriptional regulator involved in development

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003690double-stranded DNA binding IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IBA--
    GO:0008134transcription factor binding IBA--
    GO:0008301DNA binding, bending IBA--
         
    FOXN1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FOXN1:
     Decreased viability of wild-ty 

         15 MGI mutant phenotypes (inferred from 16 alleles(MGI details for Foxn1):
     cellular  endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     normal  pigmentation  reproductive system  skeleton  tumorigenesis 

    FOXN1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Foxn1tm1Nrm for FOXN1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FOXN1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FOXN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FOXN1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FOXN1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOXN1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXN1:
    hsa-miR-4314 hsa-miR-502-5p hsa-miR-3909 hsa-miR-215 hsa-miR-3153 hsa-miR-192 hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidFOXN1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FOXN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXN1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FOXN1
    Sirion Biotech Customized adenovirus for overexpression of FOXN1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for FOXN1 (see all 6)
    OriGene ORF clones in mouse, rat for FOXN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FOXN1 (NM_003593)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXN1
    Sirion Biotech Customized lentivirus for stable overexpression of FOXN1 
                         Customized lentivirus expression plasmids for stable overexpression of FOXN1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FOXN1
    Search LifeMap BioReagents cell lines for FOXN1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXN1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOXN1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FOXN1 (ENSP000002262474) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMPR2ENSP000003637084STRING: ENSP00000363708
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IBA--
    GO:0001942hair follicle development IEA--
    GO:0002260lymphocyte homeostasis IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS10767081

    FOXN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FOXN1

    Search CenterWatch for drugs/clinical trials and news about FOXN1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FOXN1 gene: 
    NM_003593.2  

    Unigene Cluster for FOXN1:

    Forkhead box N1
    Hs.663679  [show with all ESTs]
    Unigene Representative Sequence: NM_003593
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000577936 ENST00000579795 ENST00000226247(uc010crm.3 uc002hbj.3)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOXN1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXN1:
    hsa-miR-4314 hsa-miR-502-5p hsa-miR-3909 hsa-miR-215 hsa-miR-3153 hsa-miR-192 hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidFOXN1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FOXN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXN1
    Clone
    Products:
         
    OriGene clones in human, mouse for FOXN1 (see all 6)
    OriGene ORF clones in mouse, rat for FOXN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FOXN1 (NM_003593)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXN1
    Sirion Biotech Customized lentivirus for stable overexpression of FOXN1 
                         Customized lentivirus expression plasmids for stable overexpression of FOXN1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FOXN1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FOXN1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXN1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXN1

    Additional mRNA sequence: 

    AK313878.1 Y11739.1 

    1 DOTS entry:

    DT.92042910 

    3 AceView cDNA sequences:

    NM_003593 Y11739 BF836852 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FOXN1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
    SP1:                                                            
    SP2:                                                            


    ECgene alternative splicing isoforms for FOXN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FOXN1 expression in normal human tissues (normalized intensities)      FOXN1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTGTCCAG
    FOXN1 Expression
    About this image


    FOXN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Hair (Integumentary System)    fully expand to see all 4 entries
             Fetal Medulla Cells Hair Shaft

    See FOXN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FOXN1

    SOURCE GeneReport for Unigene cluster: Hs.663679

    UniProtKB/Swiss-Prot: FOXN1_HUMAN, O15353
    Tissue specificity: Expressed in thymus

        SABiosciences Expression via Pathway-Focused PCR Arrays including FOXN1: 
              Stem Cell Transcription Factors in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FOXN1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FOXN1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXN1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXN1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FOXN1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Foxn11 , 5 forkhead box N11, 5 85.13(n)1
    86.11(a)1
      11 (46.74 cM)5
    152181  NM_008238.11  NP_032264.11 
     783575775 
    chicken
    (Gallus gallus)
    Aves FOXN11 forkhead box N1 64.27(n)
    57.91(a)
      417570  XM_415816.3  XP_415816.3 
    lizard
    (Anolis carolinensis)
    Reptilia FOXN16
    Uncharacterized protein
    63(a)
    1 ↔ 1
    GL343470.1(488412-497837)
    zebrafish
    (Danio rerio)
    Actinopterygii foxn11 forkhead box N1 57.81(n)
    53.66(a)
      266748  NM_212573.1  NP_997738.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta jumu6
    jumeau
    19(a)
    1 → many
    3R(6175906-6187343)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FHL16
    Regulator of ribosomal protein transcription; has ...
    8(a)
    1 → many
    XVI(733623-736433)


    ENSEMBL Gene Tree for FOXN1 (if available)
    TreeFam Gene Tree for FOXN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FOXN1 gene
    FOXN32  FOXJ12  FOXK12  FOXN42  FOXK22  FOXP42  FOXG12  FOXJ32  
    FOXP22  FOXJ22  FOXN22  FOXP32  FOXP12  

    FOXN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/410 SNPs in FOXN1 are shown (see all 410)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048945621,2
    Cpathogenic126914631(+) ACCAGC/TGAATG 2 R * stg10--------
    VAR_0103764
    ----see VAR_0103762 A V mis40--------
    rs1112457811,2
    C--26849727(+) GGTACC/AAGCCT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs577927631,2
    C--26850445(+) TGAGG-/GCTGGC 1 -- us2k10--------
    rs106919951,2
    C--26851370(+) CGGGGCTT/-CCAAG 1 -- cds13Minor allele frequency- -:0.00CSA 8
    rs113905471,2
    C--26855494(+) ACCGAG/-GGTGA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1892922611,2
    --26907510(+) ACCCAA/GTGAAG 1 -- us2k10--------
    rs1813330771,2
    --26907512(+) CCAATA/GAAGAA 1 -- us2k10--------
    rs1491049461,2
    --26907546(+) GCAGTC/TGGACA 1 -- us2k10--------
    rs1461158741,2
    --26907797(+) CAGGTA/GGTAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FOXN1 (26833261 - 26865914 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FOXN1: --

    Human Gene Mutation Database (HGMD): FOXN1

    Locus Specific Mutation Databases (LSDB): FOXN1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FOXN1
    DNA2.0 Custom Variant and Variant Library Synthesis for FOXN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600838   
    OMIM disorders: 601705  
    UniProtKB/Swiss-Prot: FOXN1_HUMAN, O15353
  • T-cell immunodeficiency, congenital alopecia, and nail dystrophy (TIDAND) [MIM:601705]: A disorder
    characterized by the association of congenital alopecia, severe T-cell immunodeficiency, and ridging and pitting
    of all nails. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 12 diseases for FOXN1:    About MalaCards
    thymic epithelial neoplasm    t-cell immunodeficiency, congenital alopecia and nail dystrophy    alopecia and t-cell immunodeficiency    alopecia
    mediastinitis    anencephaly    neural tube defects    severe combined immunodeficiency
    hypogonadism    keratosis    vitiligo    squamous cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for FOXN1:
    Alopecia

    FOXN1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for FOXN1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    athymia 95.8 1 10483588 (1)

    Genetic Association Database (GAD): FOXN1
    Human Genome Epidemiology (HuGE) Navigator: FOXN1 (2 documents)

    Export disorders for FOXN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FOXN1 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with FOXN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of mouse and human nude genes. (PubMed id 9321431)1, 2, 3, 9 Schorpp M.... Boehm T. (1997)
    2. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    3. Exposing the human nude phenotype. (PubMed id 10206641)1, 2 Frank J.... Christiano A.M. (1999)
    4. Human clinical phenotype associated with FOXN1 mutati ons. (PubMed id 20429426)1, 9 Pignata C....Amorosi S. (2009)
    5. Transcription of the nude gene (WHN) in human normal organs and mediastinal and pulmonary tumors. (PubMed id 10483588)1, 9 Gattenlohner S....Marx A. (1999)
    6. Forkhead/winged-helix transcription factor Whn regulates hair keratin gene expression: molecular analysis of the nude skin phenotype. (PubMed id 10767081)1, 9 Schlake T....Boehm T. (2000)
    7. [Post-thymus transplant vitiligo in a child with Foxn1 deficiency]. (PubMed id 22721479)1 Levy E....Lipsker D. (2012)
    8. A variant of the LRP4 gene affects the risk of chronic lymphocytic leukaemia transformation to Richter syndrome. (PubMed id 21121903)4 Rasi S....Rossi D. (2011)
    9. FOXN1 mutation abrogates prenatal T-cell development in humans. (PubMed id 21507891)1 Vigliano I....Pignata C. (2011)
    10. A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans. (PubMed id 19729838)1 Mandinova A....Dotto G.P. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8456 HGNC: 12765 AceView: FOXN1 Ensembl:ENSG00000109101 euGenes: HUgn8456
    ECgene: FOXN1 H-InvDB: FOXN1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FOXN1 Pharmacogenomics, SNPs, Pathways
    FOXN1basehttp://bioinf.uta.fi/FOXN1base/
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/FOXN1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FOXN1 gene:
    Search GeneIP for patents involving FOXN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for FOXN1 (FoxN1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for FOXN1   OriGene RNAi products in human, mouse, rat for FOXN1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for FOXN1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FOXN1  
     OriGene qSTAR qPCR primer pairs in human, mouse for FOXN1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FOXN1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FOXN1   OriGene Custom Protein Services for FOXN1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FOXN1
     QIAGEN SeqTarget long-range PCR primers for resequencing FOXN1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXN1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXN1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXN1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXN1
     GenScript Custom Purified and Recombinant Proteins Services for FOXN1 GenScript cDNA clones with any tag delivered in your preferred vector for FOXN1
     GenScript Custom Assay Services for FOXN1 GenScript Custom Superior Antibodies Services for FOXN1
     GenScript Custom overexpressing Cell Line Services for FOXN1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FOXN1 promoter
     Search Chromatin IP Primers for FOXN1
     RT2 qPCR Primer Assay in human, mouse, rat FOXN1
     Search GNC Networks for FOXN1
     SABiosciences PCR Arrays including human, mouse, rat FOXN1
     Search Tocris compounds for FOXN1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FOXN1 antibodies
     FOXN1 proteins
     Antibodies for FOXN1
     See all of Abcam's Antibodies, Kits and Proteins for FOXN1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for FOXN1
     Antibodies for FOXN1
     ELISAs for FOXN1
     CLIAs for FOXN1
     Search LifeMap BioReagents cell lines for FOXN1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXN1
     SwitchGear 3'UTR luciferase reporter plasmids for FOXN1
     SwitchGear Promoter luciferase reporter plasmids for FOXN1
     ThermoFisher Antibodies for FOXN1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXN1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for FOXN1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FOXN1
    Customized:
     lentivirus for stable overexpression of FOXN1
     lentivirus expression plasmids for stable overexpression of FOXN1
     adenovirus for overexpression of FOXN1
     LSBio Antibodies in human, mouse, rat for FOXN1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FOXN1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4