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FOXN1 Gene

protein-coding   GIFtS: 52
GCID: GC17P026850

Forkhead Box N1

(Previous names: winged-helix nude, Rowett nude)
(Previous symbols: WHN, RONU)
  See FOXN1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Forkhead Box N11 2     Winged-Helix Transcription Factor Nude2 3
WHN1 2 3 5     FKHL202
RONU1 2 3     Forkhead Box Protein N12
Rowett Nude1 2     Winged Helix Nude2
Winged-Helix Nude1 2     

External Ids:    HGNC: 127651   Entrez Gene: 84562   Ensembl: ENSG000001091017   OMIM: 6008385   UniProtKB: O153533   

Export aliases for FOXN1 gene to outside databases

Previous GC identifers: GC17P026702 GC17P026996 GC17P023875 GC17P023059


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FOXN1 Gene:
Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic
phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is
orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to
regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the
skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been
observed. (provided by RefSeq, Jul 2008)

GeneCards Summary for FOXN1 Gene:
FOXN1 (forkhead box N1) is a protein-coding gene. Diseases associated with FOXN1 include alopecia and t-cell immunodeficiency, and thymic epithelial neoplasm. GO annotations related to this gene include double-stranded DNA binding and sequence-specific DNA binding. An important paralog of this gene is FOXF1.

UniProtKB/Swiss-Prot: FOXN1_HUMAN, O15353
Function: Transcriptional regulator involved in development

Gene Wiki entry for FOXN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FOXN1 gene promoter:
         Max1   SRF   SRF (504 AA)   Olf-1   Nkx2-5   NF-kappaB   AREB6   NF-kappaB1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOXN1 promoter sequence
   Search Chromatin IP Primers for FOXN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FOXN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11-q12   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11-q12

FOXN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXN1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P026850:  view genomic region     (about GC identifiers)

Start:
26,833,261 bp from pter      End:
26,865,914 bp from pter
Size:
32,654 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FOXN1_HUMAN, O15353 (See protein sequence)
Recommended Name: Forkhead box protein N1  
Size: 648 amino acids; 68925 Da
Secondary accessions: B2R9Q7 O15352

Explore the universe of human proteins at neXtProt for FOXN1: NX_O15353

Explore proteomics data for FOXN1 at MOPED


See FOXN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_003584.2  
ENSEMBL proteins: 
 ENSP00000462159   ENSP00000464645   ENSP00000226247  

FOXN1 Human Recombinant Protein Products:

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Search eBioscience for Proteins for FOXN1 

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
FOX: Forkhead boxes

3 InterPro protein domains:
 IPR011991 WHTH_DNA-bd_dom
 IPR018122 TF_fork_head_CS
 IPR001766 TF_fork_head

Graphical View of Domain Structure for InterPro Entry O15353

ProtoNet protein and cluster: O15353

UniProtKB/Swiss-Prot: FOXN1_HUMAN, O15353
Similarity: Contains 1 fork-head DNA-binding domain


Find genes that share domains with FOXN1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: FOXN1_HUMAN, O15353
Function: Transcriptional regulator involved in development

     Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003690double-stranded DNA binding IBA--
GO:0003700sequence-specific DNA binding transcription factor activity ----
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IBA--
GO:0008134transcription factor binding IBA--
GO:0008301DNA binding, bending IBA--
     
Find genes that share ontologies with FOXN1           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for FOXN1:
 Decreased viability of wild-ty 

     Selected MGI mutant phenotypes (inferred from 16 alleles(MGI details for Foxn1) (see all 20):
 behavior/neurological  cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland 
 growth/size/body  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system 
 integument  liver/biliary system  mortality/aging  muscle  normal 

Find genes that share phenotypes with FOXN1           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Foxn1tm1Nrm for FOXN1

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FOXN1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FOXN1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FOXN1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FOXN1

miRNA
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7 qRT-PCR Assays for microRNAs that regulate FOXN1:
hsa-miR-4314 hsa-miR-502-5p hsa-miR-3909 hsa-miR-215 hsa-miR-3153 hsa-miR-192 hsa-miR-3667-3p
SwitchGear 3'UTR luciferase reporter plasmidFOXN1 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat FOXN1

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GenScript: all cDNA clones in your preferred vector: FOXN1 (NM_003593)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXN1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXN1

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
FOXN1_HUMAN, O15353: Nucleus
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol2
cytoskeleton1
plasma membrane1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--
GO:0005667transcription factor complex IBA--

Find genes that share ontologies with FOXN1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathway & Disease-focused RT2 Profiler PCR Arrays including FOXN1: 
          Stem Cell Transcription Factors in human mouse rat
          WNT Signaling Pathway in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for FOXN1

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for FOXN1 (ENSP000002262474) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
UBE2IENSP000003248974STRING: ENSP00000324897
BMPR2ENSP000003637084STRING: ENSP00000363708
ASCL1ENSP000002667444STRING: ENSP00000266744
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Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000122negative regulation of transcription from RNA polymerase II promoter IBA--
GO:0001942hair follicle development IEA--
GO:0002260lymphocyte homeostasis IEA--
GO:0006355regulation of transcription, DNA-templated ----
GO:0006357regulation of transcription from RNA polymerase II promoter TAS10767081

Find genes that share ontologies with FOXN1           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for FOXN1



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for FOXN1 gene: 
NM_003593.2  

Unigene Cluster for FOXN1:

Forkhead box N1
Hs.663679  [show with all ESTs]
Unigene Representative Sequence: NM_003593
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000577936 ENST00000579795 ENST00000226247(uc010crm.3 uc002hbj.3)

miRNA
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Block miRNA regulation of human, mouse, rat FOXN1 using miScript Target Protectors
7 qRT-PCR Assays for microRNAs that regulate FOXN1:
hsa-miR-4314 hsa-miR-502-5p hsa-miR-3909 hsa-miR-215 hsa-miR-3153 hsa-miR-192 hsa-miR-3667-3p
SwitchGear 3'UTR luciferase reporter plasmidFOXN1 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for FOXN1
Predesigned siRNA for gene silencing in human, mouse, rat FOXN1
Clone
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: FOXN1 (NM_003593)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXN1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXN1
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for FOXN1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FOXN1
  QuantiTect SYBR Green Assays in human, mouse, rat FOXN1
  QuantiFast Probe-based Assays in human, mouse, rat FOXN1

Additional mRNA sequence: 

AK313878.1 Y11739.1 

1 DOTS entry:

DT.92042910 

3 AceView cDNA sequences:

NM_003593 Y11739 BF836852 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for FOXN1    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:                                                            
SP2:                                                            


ECgene alternative splicing isoforms for FOXN1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FOXN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTCTGTCCAG
FOXN1 Expression
About this image


FOXN1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Epithelial Cells
         Fetal Medulla Cells Hair Shaft
 
 Hair (Integumentary System)    fully expand to see all 4 entries
         Fetal Medulla Cells Hair Shaft
FOXN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

FOXN1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.663679

UniProtKB/Swiss-Prot: FOXN1_HUMAN, O15353
Tissue specificity: Expressed in thymus

    Pathway & Disease-focused RT2 Profiler PCR Arrays including FOXN1: 
          Stem Cell Transcription Factors in human mouse rat
          WNT Signaling Pathway in human mouse rat

Primer
Products:
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FOXN1
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXN1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for FOXN1 gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Foxn11 , 5 forkhead box N11, 5 85.13(n)1
86.11(a)1
  11 (46.74 cM)5
152181  NM_008238.21  NP_032264.11 
 783575775 
chicken
(Gallus gallus)
Aves FOXN11 forkhead box N1 63.57(n)
56.48(a)
  417570  XM_415816.4  XP_415816.4 
lizard
(Anolis carolinensis)
Reptilia FOXN16
forkhead box N1
64(a)
1 ↔ 1
GL343470.1(488412-497837)
tropical clawed frog
(Xenopus tropicalis)
Amphibia foxn11 forkhead box N1 59.5(n)
55.09(a)
  100485276  XM_002937144.1  XP_002937190.1 
zebrafish
(Danio rerio)
Actinopterygii foxn11 forkhead box N1 58.73(n)
54.02(a)
  266748  NM_212573.1  NP_997738.1 
fruit fly
(Drosophila melanogaster)
Insecta jumu6
jumeau
21(a)
1 → many
3R(6175906-6187343)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FHL16
Regulator of ribosomal protein transcription; has ...
9(a)
1 → many
XVI(733623-736433) YPR104C


ENSEMBL Gene Tree for FOXN1 (if available)
TreeFam Gene Tree for FOXN1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for FOXN1 gene
FOXF12  FOXQ12  FOXN32  FOXJ12  FOXF22  FOXK12  FOXN42  FOXR12  
FOXH12  FOXK22  FOXJ32  FOXG12  FOXJ22  FOXN22  FOXR22  

Find genes that share paralogs with FOXN1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FOXN1 (see all 410)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1048945621,2
Cpathogenic126914631(+) ACCAGC/TGAATG 2 R * stg10--------
rs1112457811,2
C--26849727(+) GGTACC/AAGCCT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
rs577927631,2
C--26850445(+) TGAGG-/GCTGGC 1 -- us2k10--------
rs106919951,2
C--26851370(+) CGGGGCTT/-CCAAG 1 -- cds13Minor allele frequency- -:0.00CSA 8
rs113905471,2
C--26855494(+) ACCGAG/-GGTGA 1 -- int11Minor allele frequency- -:0.00NA 2
rs1892922611,2
--26907510(+) ACCCAA/GTGAAG 1 -- us2k10--------
rs1813330771,2
--26907512(+) CCAATA/GAAGAA 1 -- us2k10--------
rs1491049461,2
--26907546(+) GCAGTC/TGGACA 1 -- us2k10--------
rs1461158741,2
--26907797(+) CAGGTA/GGTAAA 1 -- us2k10--------
rs1856235691,2
--26907841(+) AGGCCA/GGGCAC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for FOXN1 (26833261 - 26865914 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for FOXN1: --
Human Gene Mutation Database (HGMD): FOXN1
Locus Specific Mutation Databases (LSDB): FOXN1

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing FOXN1
DNA2.0 Custom Variant and Variant Library Synthesis for FOXN1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 600838   
OMIM disorders: 601705  
UniProtKB/Swiss-Prot: FOXN1_HUMAN, O15353
  • T-cell immunodeficiency, congenital alopecia, and nail dystrophy (TIDAND) [MIM:601705]: A disorder
    characterized by the association of congenital alopecia, severe T-cell immunodeficiency, and ridging and pitting
    of all nails. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 6 diseases for FOXN1:    
    About MalaCards
    alopecia and t-cell immunodeficiency    thymic epithelial neoplasm    t-cell immunodeficiency, congenital alopecia and nail dystrophy    richter's syndrome
    alopecia    anencephaly

    1 disease from the University of Copenhagen DISEASES database for FOXN1:
    Alopecia

    Find genes that share disorders with FOXN1           About GenesLikeMe

    1 Novoseek inferred disease relationship for FOXN1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    athymia 95.8 1 10483588 (1)

    Genetic Association Database (GAD): FOXN1
    Human Genome Epidemiology (HuGE) Navigator: FOXN1 (2 documents)

    Export disorders for FOXN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FOXN1 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with FOXN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of mouse and human nude genes. (PubMed id 9321431)1, 2, 3, 9 Schorpp M.... Boehm T. (Immunogenetics 1997)
    2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    3. Exposing the human nude phenotype. (PubMed id 10206641)1, 2 Frank J.... Christiano A.M. (Nature 1999)
    4. Human clinical phenotype associated with FOXN1 mutations. (PubMed id 20429426)1, 9 Pignata C....Amorosi S. (Adv. Exp. Med. Biol. 2009)
    5. Transcription of the nude gene (WHN) in human normal organs and mediastinal and pulmonary tumors. (PubMed id 10483588)1, 9 GattenlAPhner S....Marx A. (Pathol. Res. Pract. 1999)
    6. Forkhead/winged-helix transcription factor Whn regulates hair keratin gene expression: molecular analysis of the nude skin phenotype. (PubMed id 10767081)1, 9 Schlake T....Boehm T. (Dev. Dyn. 2000)
    7. [Post-thymus transplant vitiligo in a child with Foxn1 deficiency]. (PubMed id 22721479)1 Levy E....Lipsker D. (Ann Dermatol Venereol 2012)
    8. A variant of the LRP4 gene affects the risk of chronic lymphocytic leukaemia transformation to Richter syndrome. (PubMed id 21121903)4 Rasi S....Rossi D. (Br. J. Haematol. 2011)
    9. FOXN1 mutation abrogates prenatal T-cell development in humans. (PubMed id 21507891)1 Vigliano I....Pignata C. (J. Med. Genet. 2011)
    10. A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans. (PubMed id 19729838)1 Mandinova A....Dotto G.P. (J. Clin. Invest. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8456 HGNC: 12765 AceView: FOXN1 Ensembl:ENSG00000109101 euGenes: HUgn8456
    ECgene: FOXN1 H-InvDB: FOXN1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FOXN1 Pharmacogenomics, SNPs, Pathways
    FOXN1basehttp://bioinf.uta.fi/FOXN1base/
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=FOXN1[genesymbol]

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    Patent Information for FOXN1 gene:
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