FOXN1 Gene
protein-coding GIFtS: 53
GCID: GC17P026850
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forkhead box N1(Previous names: winged-helix nude, Rowett nude )
(Previous symbols: WHN, RONU)
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Aliases
for FOXN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Forkhead Box N11 2 | | Winged-Helix Nude1 2 | | WHN1 2 3 5 | | Winged-Helix Transcription Factor Nude2 3 | | RONU1 2 3 | | Forkhead Box Protein N12 | | FKHL201 2 | | Winged Helix Nude2 | | Rowett Nude1 2 | | |
Export aliases for FOXN1 gene to outside databasesPrevious GC identifers: GC17P026702 GC17P026996 GC17P023875 GC17P023059 |
Summaries
for FOXN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FOXN1:
Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropicphenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous tothe mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratingene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disordercongenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. (providedby RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: FOXN1_HUMAN, O15353Function: Transcriptional regulator involved in development
Gene Wiki entry for FOXN1
|
Genomic Views
for FOXN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010799.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FOXN1 gene promoter:
Max1 SRF SRF (504 AA) Olf-1 Nkx2-5 NF-kappaB AREB6 NF-kappaB1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for FOXN1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXN1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q11-q12 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11-q12FOXN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P026850: view genomic region
(about GC identifiers)
Start:
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26,833,261 bp from pter |
End:
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26,865,914 bp from pter |
Size:
|
32,654 bases |
Orientation:
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plus strand |
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Proteins
for FOXN1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FOXN1_HUMAN, O15353 (See
protein sequence)Recommended Name: Forkhead box protein N1 Size: 648 amino acids; 68925 Da
Subcellular location: Nucleus
Secondary accessions: B2R9Q7 O15352Explore the universe of human proteins at neXtProt for FOXN1: NX_O15353
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O15353
FOXN1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003584.2
ENSEMBL proteins: ENSP00000462159 ENSP00000464645 ENSP00000226247
Human Recombinant Protein Products for FOXN1:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
FOXN1 for ontologies About GeneDecksing
FOXN1 Antibody Products:
Assay Products for FOXN1: |
Protein
Domains /
Families
for FOXN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FOXN1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O15353ProtoNet protein and cluster: O15353 UniProtKB/Swiss-Prot: FOXN1_HUMAN, O15353Similarity: Contains 1 fork-head DNA-binding domain |
Function
for FOXN1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: FOXN1_HUMAN, O15353Function: Transcriptional regulator involved in development Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003690 | double-stranded DNA binding |
IBA | -- | | GO:0003705 | RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity |
IBA | -- | | GO:0008134 | transcription factor binding |
IBA | -- | | GO:0008301 | DNA binding, bending |
IBA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
FOXN1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for FOXN1:
15 MGI mutant phenotypes (inferred from 16 alleles ) (MGI details for Foxn1):
FOXN1 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Foxn1tm1Nrm for FOXN1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXN1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXN1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXN1 |
|
Pathways & Interactions
for FOXN1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOXN1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for FOXN1 (ENSP000002262474) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table
FOXN1 for ontologies About GeneDecksing
|
Drugs & Compounds
for FOXN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FOXN1
Search CenterWatch for drugs/clinical trials and news about FOXN1
|
Transcripts
for FOXN1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FOXN1 gene: NM_003593.2 Unigene Cluster for FOXN1: Forkhead box N1 Hs.663679 [show with all ESTs]Unigene Representative Sequence: NM_0035933 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000577936 ENST00000579795 ENST00000226247(uc010crm.3 uc002hbj.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXN1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXN1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FOXN1 (NM_003593) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOXN1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXN1 |
Additional cDNA sequence: AK313878.1 Y11739.1 1 DOTS entry: DT.92042910 3 AceView cDNA sequences: NM_003593 Y11739 BF836852
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for FOXN1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FOXN1
|
Expression
for FOXN1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FOXN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCTGTCCAG
About this image
See FOXN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FOXN1
SOURCE GeneReport for Unigene cluster: Hs.663679
UniProtKB/Swiss-Prot: FOXN1_HUMAN, O15353Tissue specificity: Expressed in thymus
SABiosciences Expression via Pathway-Focused PCR Arrays including FOXN1: | Stem Cell Transcription Factors in human mouse rat | | WNT Signaling Pathway in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOXN1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXN1 |
Orthologs
for FOXN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FOXN1 gene from 4/17 species (see all 17) About this table
ENSEMBL Gene Tree for FOXN1 (if available)
TreeFam Gene Tree for FOXN1 (if available) |
Paralogs
for FOXN1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FOXN1 gene
- FOXJ12 FOXN32 FOXK12 FOXN42 FOXK22 FOXP42 FOXG12 FOXJ32
- FOXJ22 FOXP22 FOXN22 FOXP32 FOXP12
1 SIMAP similar gene for FOXN1 using alignment to 2 protein entries: FOXN1_HUMAN (see all proteins):FOXN4
FOXN1 for paralogs About GeneDecksing
|
Genomic Variants
for FOXN1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FOXN1 (26833261 - 26865914 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FOXN1: --
Human Gene Mutation Database (HGMD): FOXN1
Locus Specific Mutation Databases (LSDB): FOXN1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOXN1 |
|
Disorders
/ Diseases
for FOXN1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FOXN1 for disorders About GeneDecksing
OMIM gene information: 600838
OMIM disorders: 601705
UniProtKB/Swiss-Prot: FOXN1_HUMAN, O15353
Defects in FOXN1 are the cause of T-cell immunodeficiency congenital alopecia and nail dystrophy (TIDAND)[MIM:601705]. A disorder characterized by the association of congenital alopecia, severe T-cell immunodeficiency, andridging and pitting of all nails
14  diseases for FOXN1: About MalaCardsalopecia t-cell immunodeficiency, congenital alopecia and nail dystrophy immunodeficiency neural tube defect
severe combined immunodeficiency combined immunodeficiency anencephaly nevus
squamous cell carcinoma mediastinitis keratosis hypogonadism
hermaphroditism carcinoma
1 disease from the University of Copenhagen DISEASES database for FOXN1:Alopecia 1 Novoseek disease relationship for FOXN1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| athymia |
95.8 |
1 |
10483588 (1) |
Human Genome Epidemiology (HuGE) Navigator: FOXN1 (2 documents)
Export disorders for FOXN1 gene to outside databases
|
Publications
for FOXN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FOXN1 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with FOXN1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of mouse and human nude genes. (PubMed id 9321431)1, 2, 3, 9 Schorpp M.... Boehm T. (1997)
- Exposing the human nude phenotype. (PubMed id 10206641)1, 2 Frank J.... Christiano A.M. (1999)
- Human clinical phenotype associated with FOXN1 mutati ons. (PubMed id 20429426)1, 9 Pignata C....Amorosi S. (2009)
- Transcription of the nude gene (WHN) in human normal organs and mediastinal and pulmonary tumors. (PubMed id 10483588)1, 9 Gattenlohner S....Marx A. (1999)
- Forkhead/winged-helix transcription factor Whn regulates hair keratin gene expression: molecular analysis of the nude skin phenotype. (PubMed id 10767081)1, 9 Schlake T....Boehm T. (2000)
- [Post-thymus transplant vitiligo in a child with Foxn1 deficiency]. (PubMed id 22721479)1 Levy E....Lipsker D. (2012)
- FOXN1 mutation abrogates prenatal T-cell development in humans. (PubMed id 21507891)1 Vigliano I....Pignata C. (2011)
- Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1 Jugessur A....Murray J.C. (2010)
- A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans. (PubMed id 19729838)1 Mandinova A....Dotto G.P. (2009)
- Dedicated epithelial recipient cells determine pigmentation patterns. (PubMed id 17803914)1 Weiner L....Brissette J.L. (2007)
|
External Searches for FOXN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FOXN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FOXN1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FOXN1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FOXN1 | Pharmacogenomics, SNPs, Pathways | | FOXN1base | http://bioinf.uta.fi/FOXN1base/ | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/FOXN1 |
|
| | |
About This Section
| Patent Information for FOXN1 gene:
Search GeneIP for patents involving FOXN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FOXN1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for FOXN1 | | OriGene Custom Protein Services for FOXN1 | | | OriGene Custom Immunoassay Development | | |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXN1 |
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