Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FOXM1 Gene

protein-coding   GIFtS: 63
GCID: GC12M002966

forkhead box M1


(Previous symbol: FKHL16)
 Explore 46 diseases affiliated with
FOXM1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FOXM1    

Aliases
for FOXM1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Forkhead Box M11 2     Winged-Helix Factor From INS-1 Cells2 3
FKHL161 2 3 5     HNF-3/Fork-Head Homolog 112 3
HFH-111 2 3     M-Phase Phosphoprotein 22 3
MPP21 2 3     MPM-2 Reactive Phosphoprotein 22 3
HFH112 3 5     Trident1
HNF-31 2     FOXM1B2
INS-11 2     MPP-22
MPHOSPH21 2     PIG292
TGT31 2     TRIDENT2
Forkhead-Related Protein FKHL162 3     Forkhead Box Protein M12
Hepatocyte Nuclear Factor 3 Forkhead Homolog 112 3     Forkhead, Drosophila, Homolog-Like 162
Transcription Factor Trident2 3     WIN3

External Ids:    HGNC: 38181   Entrez Gene: 23052   Ensembl: ENSG000001112067   OMIM: 6023415   UniProtKB: Q080503   

Export aliases for FOXM1 gene to outside databases

Previous GC identifers: GC12M002839 GC12M002837


Summaries
for FOXM1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FOXM1:
The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is
phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1.
Several transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2011)

UniProtKB/Swiss-Prot: FOXM1_HUMAN, Q08050
Function: Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and
mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in
the DNA damage checkpoint response

Gene Wiki entry for FOXM1


Genomic Views
for FOXM1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009759.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FOXM1 gene promoter:
         CREB   deltaCREB   C/EBPalpha   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FOXM1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FOXM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.33   HGNC cytogenetic band: 12p13

FOXM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXM1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M002966:  view genomic region     (about GC identifiers)

Start:
 2,966,847 bp from pter      End:
 2,986,303 bp from pter
Size:
 19,457 bases      Orientation:
 minus strand

Proteins
for FOXM1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FOXM1_HUMAN, Q08050 (See protein sequence)
Recommended Name: Forkhead box protein M1  
Size: 763 amino acids; 84283 Da
Subcellular location: Nucleus
Developmental stage: Embryonic expression pattern: liver, lung, intestine, kidney, urinary tract; adult expression
pattern: intestine, colon, testis and thymus
1 PDB 3D structure from and Proteopedia for FOXM1:
3G73 (3D)    
Secondary accessions: O43258 O43259 O43260 Q4ZGG7 Q9BRL2
Alternative splicing: 3 isoforms:  Q08050-1   Q08050-2   Q08050-3   

Explore the universe of human proteins at neXtProt for FOXM1: NX_Q08050

Post-translational modifications:

  • Phosphorylated in M (mitotic) phase. Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases
    • the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair. Phosphorylated by
    CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and
    phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key
    mitotic regulators1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q08050

    • FOXM1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001230017.1  NP_001230018.1  NP_068772.2  NP_973731.1  NP_973732.1  

    ENSEMBL proteins: 
     ENSP00000342307   ENSP00000354492   ENSP00000352901   ENSP00000442309   ENSP00000444541  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 4): FOXM1
    OriGene Custom Protein Services for FOXM1 
    GenScript Custom Purified and Recombinant Proteins Services for FOXM1
    Novus Biologicals FOXM1 Proteins
    Novus Biologicals FOXM1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FOXM1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005667transcription factor complex IBA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0043231intracellular membrane-bounded organelle ----


    FOXM1 for ontologies           About GeneDecksing



    FOXM1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of FOXM1
    R&D Systems Antibodies for FOXM1
    Cell Signaling Technology (CST) Antibodies for FOXM1 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FOXM1 
    GenScript Custom Superior Antibodies Services for FOXM1
    Novus Biologicals FOXM1 Antibodies
    Abcam antibodies for FOXM1 
    Uscn Antibodies for FOXM1
    ThermoFisher Antibodies for FOXM1

    Assay Products for FOXM1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FOXM1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for FOXM1

    Protein Domains /
    Families
    for FOXM1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FOXM1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry Q08050

    ProtoNet protein and cluster: Q08050

    UniProtKB/Swiss-Prot: FOXM1_HUMAN, Q08050
    Domain: Within the protein there is a domain which acts as a transcriptional activator. Insertion of a splicing
    sequence within it inactivates this transcriptional activity, as it is the case for isoform 4
    Similarity: Contains 1 fork-head DNA-binding domain


    Function
    for FOXM1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FOXM1_HUMAN, Q08050
    Function: Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and
    mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in
    the DNA damage checkpoint response
    Induction: Induced during liver regeneration and oxidative stress

         Genatlas biochemistry entry for FOXM1:
    transcription factor-like 16,with a Drosophila homeo forkhead DNA binding domain,mouse Trident homolog,expressed in
    cycling cells,involved in cell proliferation

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 3): FOXM1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOXM1
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXM1 (see all 24):
    hsa-miR-320a hsa-miR-361-5p hsa-miR-509-5p hsa-miR-1260b hsa-miR-1205 hsa-miR-3167 hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmid: FOXM1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOXM1 (see all 7)
    OriGene shRNA RFP: FOXM1
    OriGene siRNA: FOXM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXM1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for FOXM1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXM1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXM1 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): FOXM1 (NM_202003)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXM1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for FOXM1
    Search LifeMap BioReagents cell lines for FOXM1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXM1

    Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS9242644
    GO:0003690double-stranded DNA binding IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9441747
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IBA--
    GO:0005515protein binding IPI--


    FOXM1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for FOXM1:
     Decreased number of cells in m  Decreased viability 

    Animal Models:
         Mouse knock-outs for FOXM1: Foxm1tm1.1Rhc Foxm1tm1Cle
         10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Foxm1):
     cardiovascular system  cellular  endocrine/exocrine gland  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  muscle  respiratory system  tumorigenesis 

    FOXM1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FOXM1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell Cycle / Checkpoint Control
    		Cell Cycle / Checkpoint Control1.00
    2Selected targets of C/EBPalpha
    		Selected targets of C/EBPalpha1.00
    3SIDS Susceptibility Pathways
    		SIDS Susceptibility Pathways1.00
    4FOXM1 transcription factor network
    		FOXM1 transcription factor network1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for FOXM1
        Selected targets of C/EBPalpha


    1 Cell Signaling Technology (CST) Pathway for FOXM1
        Cell Cycle / Checkpoint Control

    2 BioSystems Pathways for FOXM1 
        SIDS Susceptibility Pathways
    FOXM1 transcription factor network



    FOXM1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FOXM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/46 Interacting proteins for FOXM1 (Q080501, 2, 3 ENSP000003423074) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FOXO3O435241, 3, ENSP000003395274EBI-866480,EBI-1644164 I2D: score=1 STRING: ENSP00000339527
    CCNE1P248642, 3, ENSP000002626434MINT-1788668 MINT-1788648 I2D: score=2 STRING: ENSP00000262643
    CDK2P249413, ENSP000002669704I2D: score=4 STRING: ENSP00000266970
    CREBBPQ927933, ENSP000002623674I2D: score=4 STRING: ENSP00000262367
    CDH1P128303, ENSP000002617694I2D: score=1 STRING: ENSP00000261769
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle IDA19160488
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP--
    GO:0001558regulation of cell growth TAS10523841
    GO:0001570vasculogenesis IBA--
    GO:0001889liver development IBA--


    FOXM1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FOXM1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FOXM1 for compounds           About GeneDecksing

    EMD Millipore small molecules for FOXM1:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for FOXM1

    Compounds for FOXM1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Thiostrepton Antibiotic, inhibits protein synthesis [1393-48-2]
    10/13 Novoseek chemical compound relationships for FOXM1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphoenolpyruvate 48.1 2 10913147 (1), 7565696 (1)
    diethylnitrosamine 37.8 4 18393292 (1), 17173139 (1), 15082532 (1)
    phenobarbital 26.4 2 17173139 (1), 15082532 (1)
    chloramphenicol 19.7 1 10915785 (1)
    12-o-tetradecanoylphorbol 13-acetate 8.87 3 9252399 (2)
    sterol 4.72 1 1312351 (1)
    oligonucleotide 0 2 8216221 (1)
    pyruvate 0 1 7565696 (1)
    glucose 0 3 10799560 (1), 10899756 (1), 11915024 (1)
    steroid 0 1 12505310 (1)

    Search CenterWatch for drugs/clinical trials and news about FOXM1 

    Transcripts
    for FOXM1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FOXM1 gene (5 alternative transcripts): 
    NM_001243088.1  NM_001243089.1  NM_021953.3  NM_202002.2  NM_202003.2  

    Unigene Cluster for FOXM1:

    Forkhead box M1
    Hs.239  [show with all ESTs]
    Unigene Representative Sequence: NM_202002
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000536066 ENST00000342628(uc001qle.3) ENST00000361953(uc001qlf.3 uc009zea.3 uc009zeb.3 uc001qlg.3)
    ENST00000359843 ENST00000535350 ENST00000366362 ENST00000538564 ENST00000537018
    ENST00000545049

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): FOXM1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOXM1
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXM1 (see all 24):
    hsa-miR-320a hsa-miR-361-5p hsa-miR-509-5p hsa-miR-1260b hsa-miR-1205 hsa-miR-3167 hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmid: FOXM1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOXM1 (see all 7)
    OriGene shRNA RFP: FOXM1
    OriGene siRNA: FOXM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXM1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXM1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXM1 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): FOXM1 (NM_202003)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXM1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOXM1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FOXM1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXM1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXM1

    Additional cDNA sequence: 

    AK291206.1 AK313845.1 AY542306.1 BC006192.2 BC006529.2 BC012863.1 BC035437.1 BC141948.1 
    BT006986.1 L16783.1 U74612.1 U74613.1 U83113.1 

    19 DOTS entries:

    DT.99935171  DT.91780290  DT.95150162  DT.95150163  DT.100793732  DT.100793735  DT.101983665  DT.97784909 
    DT.91780242  DT.95150173  DT.121115043  DT.87078457  DT.102843547  DT.75189455  DT.100029741  DT.87078460 
    DT.95150169  DT.121115163  DT.91780292 

    24/283 AceView cDNA sequences (see all 283):

    BM454817 AA832447 AA864486 BP432178 BM806302 BQ955204 AL525853 BQ229497 
    BU507075 BF439808 BU556682 BT006986 CB105341 BQ689987 AA873051 NM_202003 
    BC012863 BX281557 BG576093 BU956485 BQ671727 NM_021953 BF109425 U74612 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for FOXM1 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b
    SP1:                                                                    -                                                               
    SP2:                                                                    -           -                             -     -               
    SP3:                                                                    -                                         -     -               
    SP4:                                                                    -                                         -     -               
    SP5:                                                                    -           -                                                   


    ECgene alternative splicing isoforms for FOXM1

    Expression
    for FOXM1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FOXM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGTGTGAGCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FOXM1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverIntrahepatic Biliary TreeImmature Biliary Epithelial CellsLiver
    LiverLiver BudHepatoblastsLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)

    See FOXM1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FOXM1

    SOURCE GeneReport for Unigene cluster: Hs.239

    UniProtKB/Swiss-Prot: FOXM1_HUMAN, Q08050
    Tissue specificity: Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only
    in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial
    cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in testis

        SABiosciences Expression via Pathway-Focused PCR Arrays including FOXM1: 
              Angiogenic Growth Factors in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOXM1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FOXM1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXM1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXM1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXM1

    Orthologs
    for FOXM1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FOXM1 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FOXM11 forkhead box M1 60.47(n)
    54.51(a)    		   430534  NM_001012955.1  NP_001012973.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FOXM16
    		 --
    		 47(a)
    		 1 ↔ 1
    		 5(80645120-80664228)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc638542 similar to forkhead box M1 75.33(n)   394072  BC054560.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG320066
    		 --
    		 12(a)
    		 1 ↔ 1
    		 4(171390-174164)


    ENSEMBL Gene Tree for FOXM1 (if available)
    TreeFam Gene Tree for FOXM1 (if available) 

    Paralogs
    for FOXM1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for FOXM1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/489 NCBI SNPs in FOXM1 are shown (see all 489)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs289198781,2
    		C,--2823894(-) GCTATC/ACCCTG 1 -- us2k16Minor allele frequency- A:0.02NS WA 304
    rs289198771,2
    		C,--2823947(-) TGCCCG/AGCAGC 1 -- us2k16Minor allele frequency- A:0.01NS EA 308
    rs289198761,2
    		C,F,--2824039(-) CATTAG/CGGCAG 1 -- us2k16Minor allele frequency- C:0.02NS NA 308
    rs289198751,2
    		C,F,--2824051(-) GGGCCC/TCCTGA 1 -- us2k15Minor allele frequency- T:0.02NS 188
    rs289198741,2
    		C,F,--2824107(-) TGCTGG/ATTAAC 1 -- us2k16Minor allele frequency- A:0.07NS WA 308
    rs289198731,2
    		C,--2824420(-) TGACCG/ACATGG 1 -- us2k1 ese38Minor allele frequency- A:0.01NS NA WA 310
    rs118311221,2
    		C,F,H,--2825040(+) ATGGAA/GACAGG 1 -- us2k19Minor allele frequency- G:0.09NS CSA WA 304
    rs289198711,2
    		C,F,H,--2825053(-) AGGAAC/TCCCCC 1 -- us2k110Minor allele frequency- T:0.01NS NA 962
    rs57960321,2
    		C,--2845367(+) ATGAG-/TTTTTT 1 -- int1 trp32Minor allele frequency- T:0.00NA CSA 4
    rs1455684221,2
    		--2966630(+) AGAGAC/TGCCAG 7 -- ds5001 int1 us2k10--------

    HapMap Linkage Disequilibrium report for FOXM1 (2966847 - 2986303 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for FOXM1
         1 CNV: 4766

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOXM1
    DNA2.0 Custom Variant and Variant Library Synthesis for FOXM1

    Disorders / Diseases
    for FOXM1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FOXM1 for disorders           About GeneDecksing

    OMIM gene information: 602341    OMIM disorders: --

    20/46 diseases for FOXM1 (see all 46):    About MalaCards
    central pontine myelinolysis    asphyxiating thoracic dystrophy    maturity-onset diabetes of the young    protein c deficiency
    non-small cell lung carcinoma    sclerosing hemangioma    pulmonary sclerosing hemangioma    anaplastic astrocytoma
    laryngeal squamous cell carcinoma    metabolic disorders    hemangioma    squamous cell carcinoma
    achondroplasia    basal cell carcinoma    acute myeloid leukemia    insulinoma
    myeloid leukemia    hepatitis b    astrocytoma    hepatocellular carcinoma

    4 diseases from the University of Copenhagen DISEASES database for FOXM1:
    Diabetes mellitus     Central pontine myelinolysis     maturity-onset diabetes of the young     Hepatocellular carcinoma

    10/18 Novoseek disease relationships for FOXM1 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    protein c deficiency 48.3 1 7592627 (1)
    anaplastic astrocytoma 43.9 7 18974115 (1), 17404569 (1), 16489016 (1)
    adenocarcinoma lung 42.3 2 18345025 (1), 16489016 (1)
    hepatocellular carcinoma 31.8 4 17173139 (2), 19136513 (1), 16489016 (1)
    tumor liver 27.6 1 16452231 (1)
    glioblastoma 22.9 15 16585184 (3), 18974115 (2), 17404569 (1), 16489016 (1)
    insulinoma 16.9 2 9242644 (2)
    response acute phase 14.1 2 7862129 (1)
    glioma 8.66 31 17404569 (7), 18974115 (6), 16585184 (3), 12183437 (1)
    carcinoma basal cell 7.27 2 12183437 (1), 16489016 (1)

    Human Genome Epidemiology (HuGE) Navigator: FOXM1 (2 documents)

    Export disorders for FOXM1 gene to outside databases

    Publications
    for FOXM1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FOXM1 gene, integrated from 9 sources (see all 250):
    (articles sorted by number of sources associating them with FOXM1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues. (PubMed id 9032290)1, 2, 3, 9 Ye H.... Costa R.H. (1997)
    2. Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain. (PubMed id 9242644)1, 2, 9 Yao K.-M.... Wong G.G. (1997)
    3. The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization. (PubMed id 9441747)1, 3, 9 Korver W....Clevers H. (1997)
    4. Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression. (PubMed id 19160488)1, 2 Fu Z....Chen J. (2008)
    5. Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes. (PubMed id 17101782)1, 2 Tan Y....Costa R.H. (2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope. (PubMed id 8290587)1, 2 Westendorf J.M.... Gerace L. (1994)
    8. FoxM1B transcriptionally regulates vascular endothelial growth factor expression and promotes the angiogenesis and growth of glioma cells. (PubMed id 18974115)1, 9 Zhang Y....Huang S. (2008)
    9. Critical role and regulation of transcription factor FoxM1 in human gastric cancer angiogenesis and progression. (PubMed id 19351851)1, 9 Li Q....Xie K. (2009)
    10. FOXM1 is a downstream target of Gli1 in basal cell carcinomas. (PubMed id 12183437)1, 9 Teh M.T....Quinn A.G. (2002)

    External Searches for FOXM1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FOXM1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2305 HGNC: 3818 AceView: FOXM1 Ensembl:ENSG00000111206 euGenes: HUgn2305
    ECgene: FOXM1 H-InvDB: FOXM1

    Other Databases showing FOXM1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FOXM1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FOXM1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FOXM1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/foxm1/

    Intellectual Property
    for FOXM1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FOXM1 gene:
    Search GeneIP for patents involving FOXM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for FOXM1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of FOXM1
     EMD Millipore small molecules (inhibitor) for FOXM1
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for FOXM1 (FoxM1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for FOXM1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOXM1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOXM1  
     OriGene Protein Over-expression Lysate for FOXM1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for FOXM1   OriGene 3'-UTR Clone for FOXM1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXM1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXM1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FOXM1   OriGene Custom Protein Services for FOXM1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FOXM1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOXM1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXM1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXM1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXM1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXM1
     GenScript Custom Purified and Recombinant Proteins Services for FOXM1 GenScript cDNA clones with any tag delivered in your preferred vector for FOXM1
     GenScript Custom Assay Services for FOXM1 GenScript Custom Superior Antibodies Services for FOXM1
     GenScript Custom overexpressing Cell Line Services for FOXM1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for FOXM1 

     Regulatory tfbs in FOXM1 promoter
     Search Chromatin IP Primers for FOXM1
     RT2 qPCR Primer Assay in human, mouse, rat FOXM1
     GNC Network for FOXM1
     SABiosciences PCR Arrays including human, mouse, rat FOXM1
     Tocris compounds for FOXM1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Drugs for FOXM1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FOXM1 antibodies
     FOXM1 proteins
     FOXM1 lysates
     Antibodies for FOXM1
     See all of Abcam's Antibodies, Kits and Proteins for FOXM1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     FOXM1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for FOXM1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXM1
     SwitchGear 3'UTR luciferase reporter plasmids for FOXM1
     SwitchGear Promoter luciferase reporter plasmids for FOXM1
     ThermoFisher Antibodies for FOXM1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXM1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      FOXM1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4