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FOXM1 Gene

protein-coding   GIFtS: 65
GCID: GC12M002966

Forkhead Box M1


(Previous symbol: FKHL16)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Forkhead Box M11 2     FOXM1B2
FKHL161 2 3 5     HNF-32
M-Phase Phosphoprotein 21 2 3     INS-12
HFH112 3 5     MPHOSPH22
Forkhead-Related Protein FKHL162 3     MPP-22
Hepatocyte Nuclear Factor 3 Forkhead Homolog 112 3     PIG292
Transcription Factor Trident2 3     TGT32
Winged-Helix Factor From INS-1 Cells2 3     TRIDENT2
HFH-112 3     Forkhead Box Protein M12
MPP22 3     Forkhead, Drosophila, Homolog-Like 162
HNF-3/Fork-Head Homolog 112 3     WIN3
MPM-2 Reactive Phosphoprotein 22 3     

External Ids:    HGNC: 38181   Entrez Gene: 23052   Ensembl: ENSG000001112067   OMIM: 6023415   UniProtKB: Q080503   

Export aliases for FOXM1 gene to outside databases

Previous GC identifers: GC12M002839 GC12M002837


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FOXM1 Gene:
The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded
protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1
and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. (provided
by RefSeq, Jul 2011)

GeneCards Summary for FOXM1 Gene:
FOXM1 (forkhead box M1) is a protein-coding gene. Diseases associated with FOXM1 include central pontine myelinolysis, and cancer progression/metastasis. GO annotations related to this gene include protein kinase binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOXO6.

UniProtKB/Swiss-Prot: FOXM1_HUMAN, Q08050
Function: Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and
mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating
in the DNA damage checkpoint response

Gene Wiki entry for FOXM1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_009759.17  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FOXM1 gene promoter:
         CREB   deltaCREB   C/EBPalpha   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOXM1 promoter sequence
   Search Chromatin IP Primers for FOXM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FOXM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.33   HGNC cytogenetic band: 12p13

FOXM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXM1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M002966:  view genomic region     (about GC identifiers)

Start:
2,966,847 bp from pter      End:
2,986,303 bp from pter
Size:
19,457 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FOXM1_HUMAN, Q08050 (See protein sequence)
Recommended Name: Forkhead box protein M1  
Size: 763 amino acids; 84283 Da
Developmental stage: Embryonic expression pattern: liver, lung, intestine, kidney, urinary tract; adult expression
pattern: intestine, colon, testis and thymus
1 PDB 3D structure from and Proteopedia for FOXM1:
3G73 (3D)    
Secondary accessions: O43258 O43259 O43260 Q4ZGG7 Q9BRL2
Alternative splicing: 3 isoforms:  Q08050-1   Q08050-2   Q08050-3   

Explore the universe of human proteins at neXtProt for FOXM1: NX_Q08050

Explore proteomics data for FOXM1 at MOPED

Post-translational modifications: 

  • Phosphorylated in M (mitotic) phase. Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage
    increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair.
    Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1.
    Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and
    subsequent enhanced expression of key mitotic regulators1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FOXM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001230017.1  NP_001230018.1  NP_068772.2  NP_973731.1  NP_973732.1  

    ENSEMBL proteins: 
     ENSP00000342307   ENSP00000354492   ENSP00000352901   ENSP00000442309   ENSP00000444541  
    Reactome Protein details: Q08050

    FOXM1 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for FOXM1

    FOXM1 Antibody Products:

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    Cloud-Clone Corp. CLIAs for FOXM1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FOX: Forkhead boxes

    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry Q08050

    ProtoNet protein and cluster: Q08050

    UniProtKB/Swiss-Prot: FOXM1_HUMAN, Q08050
    Domain: Within the protein there is a domain which acts as a transcriptional activator. Insertion of a splicing
    sequence within it inactivates this transcriptional activity, as it is the case for isoform 4
    Similarity: Contains 1 fork-head DNA-binding domain


    FOXM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOXM1_HUMAN, Q08050
    Function: Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and
    mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating
    in the DNA damage checkpoint response
    Induction: Induced during liver regeneration and oxidative stress

         Genatlas biochemistry entry for FOXM1:
    transcription factor-like 16,with a Drosophila homeo forkhead DNA binding domain,mouse Trident homolog,expressed
    in cycling cells,involved in cell proliferation

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS9242644
    GO:0003690double-stranded DNA binding IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9441747
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IBA--
    GO:0005515protein binding IPI10523841
         
    FOXM1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FOXM1:
     Decreased number of cells in m  Decreased viability 

         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Foxm1):
     cardiovascular system  cellular  endocrine/exocrine gland  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  muscle  respiratory system  tumorigenesis 

    FOXM1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FOXM1: Foxm1tm1.1Rhc Foxm1tm1Cle

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FOXM1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FOXM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FOXM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FOXM1

    miRNA
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    miRTarBase miRNAs that target FOXM1:
    hsa-mir-186-5p (MIRT045084), hsa-mir-26b-5p (MIRT030070), hsa-mir-149-5p (MIRT052645), hsa-mir-134-5p (MIRT006979)

    Block miRNA regulation of human, mouse, rat FOXM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FOXM1 (see all 24):
    hsa-miR-320a hsa-miR-361-5p hsa-miR-509-5p hsa-miR-1260b hsa-miR-1205 hsa-miR-3167 hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidFOXM1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FOXM1
    Predesigned siRNA for gene silencing in human, mouse, rat FOXM1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): FOXM1 (NM_202003)
    Sino Biological Human cDNA Clone for FOXM1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXM1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FOXM1_HUMAN, Q08050: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    endoplasmic reticulum2
    extracellular2
    mitochondrion2
    plasma membrane2
    cytoskeleton1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IBA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    FOXM1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FOXM1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Regulation of PLK1 Activity at G2/M Transition
    G2/M Transition0.70
    Polo-like kinase mediated events0.00
    Mitotic G2-G2/M phases0.69
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    3Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    4SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways
    5Selected targets of C EBPalpha
    Selected targets of C EBPalpha

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for FOXM1
        Cell Cycle / Checkpoint Control

    2 BioSystems Pathways for FOXM1
        SIDS Susceptibility Pathways
    FOXM1 transcription factor network


    2 Reactome Pathways for FOXM1
        Polo-like kinase mediated events
    Cyclin A/B1 associated events during G2/M transition



    FOXM1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FOXM1: 
              Angiogenic Growth Factors in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FOXM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FOXM1 (Q080501, 2, 3 ENSP000003423074) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FOXO3O435241, 3, ENSP000003395274EBI-866480,EBI-1644164 I2D: score=1 STRING: ENSP00000339527
    CCNE1P248641, 2, 3, ENSP000002626434EBI-866480,EBI-519526 MINT-1788668 MINT-1788648 I2D: score=2 STRING: ENSP00000262643
    CDK2P249413, ENSP000002669704I2D: score=4 STRING: ENSP00000266970
    CREBBPQ927933, ENSP000002623674I2D: score=4 STRING: ENSP00000262367
    CDH1P128303, ENSP000002617694I2D: score=1 STRING: ENSP00000261769
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP--
    GO:0000278mitotic cell cycle TAS--
    GO:0001558regulation of cell growth TAS10523841
    GO:0001570vasculogenesis IBA--

    FOXM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for FOXM1
      Browse compounds at ApexBio 

    Compounds for FOXM1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    StauprimideInhibits NME2 nuclear translocation; primes ESCs for differentiation[154589-96-5]
    UNC 926 hydrochlorideL3MBTL1 domain inhibitor[1184136-10-4]
    GANT 61GLI antagonist; inhibits Hedgehog (Hh) signaling[500579-04-4]
    KL 001Cryptochrome protein stabilizer; lengthens circadian period[309928-48-1]
    BI 6015Hepatocyte nuclear factor 4alpha (HNF4alpha) antagonist[93987-29-2]

    Selected Novoseek inferred chemical compound relationships for FOXM1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphoenolpyruvate 48.1 2 10913147 (1), 7565696 (1)
    diethylnitrosamine 37.8 4 18393292 (1), 17173139 (1), 15082532 (1)
    phenobarbital 26.4 2 17173139 (1), 15082532 (1)
    chloramphenicol 19.7 1 10915785 (1)
    12-o-tetradecanoylphorbol 13-acetate 8.87 3 9252399 (2)
    sterol 4.72 1 1312351 (1)
    oligonucleotide 0 2 8216221 (1)
    pyruvate 0 1 7565696 (1)
    glucose 0 3 10799560 (1), 10899756 (1), 11915024 (1)
    steroid 0 1 12505310 (1)



    FOXM1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FOXM1 gene (5 alternative transcripts): 
    NM_001243088.1  NM_001243089.1  NM_021953.3  NM_202002.2  NM_202003.2  

    Unigene Cluster for FOXM1:

    Forkhead box M1
    Hs.239  [show with all ESTs]
    Unigene Representative Sequence: NM_202002
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000536066 ENST00000342628(uc001qle.3) ENST00000361953(uc001qlf.3 uc009zea.3 uc009zeb.3 uc001qlg.3)
    ENST00000359843 ENST00000535350 ENST00000366362 ENST00000538564 ENST00000537018
    ENST00000545049
    miRNA
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    hsa-miR-320a hsa-miR-361-5p hsa-miR-509-5p hsa-miR-1260b hsa-miR-1205 hsa-miR-3167 hsa-miR-3916 hsa-miR-3125
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      QuantiFast Probe-based Assays in human, mouse, rat FOXM1

    Additional mRNA sequence: 

    AK291206.1 AK313845.1 AY542306.1 BC006192.2 BC006529.2 BC012863.1 BC035437.1 BC141948.1 
    BT006986.1 L16783.1 U74612.1 U74613.1 U83113.1 

    19 DOTS entries:

    DT.99935171  DT.91780290  DT.95150162  DT.95150163  DT.100793732  DT.100793735  DT.101983665  DT.97784909 
    DT.91780242  DT.95150173  DT.121115043  DT.87078457  DT.102843547  DT.75189455  DT.100029741  DT.87078460 
    DT.95150169  DT.121115163  DT.91780292 

    Selected AceView cDNA sequences (see all 283):

    BP335305 BU507075 AL525853 BU509641 BQ073368 BU556892 BQ278162 BC006192 
    BQ771703 U74613 BF109425 BU556682 BQ689987 BE267998 BM915796 BG106083 
    BE295496 BM558740 BQ002863 BF439808 CB105341 L16783 BX281557 BU902999 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FOXM1 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b
    SP1:                                                                    -                                                               
    SP2:                                                                    -           -                             -     -               
    SP3:                                                                    -                                         -     -               
    SP4:                                                                    -                                         -     -               
    SP5:                                                                    -           -                                                   


    ECgene alternative splicing isoforms for FOXM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    FOXM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGTGAGCC
    FOXM1 Expression
    About this image


    FOXM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Liver (Hepatobiliary System)    fully expand to see all 3 entries
             Immature Biliary Epithelial Cells Intrahepatic Biliary Tree
     
     Epithelial Cells
             Immature Biliary Epithelial Cells Intrahepatic Biliary Tree
     
     NULL (Uncategorized)
             Mesenchymal Progenitor Cells - Passage 2
    FOXM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FOXM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.239

    UniProtKB/Swiss-Prot: FOXM1_HUMAN, Q08050
    Tissue specificity: Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed
    only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in
    epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in
    testis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FOXM1: 
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              Nitric Oxide Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FOXM1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Foxm11 , 5 forkhead box M11, 5 82.5(n)1
    80.69(a)1
      6 (62.98 cM)5
    142351  NM_008021.41  NP_032047.41 
     1283629675 
    chicken
    (Gallus gallus)
    Aves FOXM11 forkhead box M1 60.66(n)
    55.01(a)
      430534  NM_001012955.1  NP_001012973.1 
    lizard
    (Anolis carolinensis)
    Reptilia FOXM16
    forkhead box M1
    47(a)
    1 ↔ 1
    5(80645120-80672739)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia foxm11 forkhead box M1 56.02(n)
    51.01(a)
      100492241  XM_002941382.2  XP_002941428.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc638542 similar to forkhead box M1 75.33(n)   394072  BC054560.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fd102C6
    forkhead domain 102C
    11(a)
    many ↔ many
    4(857610-865132)
    worm
    (Caenorhabditis elegans)
    Secernentea fkh-96
    Protein FKH-9, isoform a
    24(a)
    1 ↔ 1
    X(3816925-3826963) WBGene00001441
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HCM16
    Forkhead transcription factor that drives S-phase ...
    14(a)
    1 → many
    III(229310-231004) YCR065W


    ENSEMBL Gene Tree for FOXM1 (if available)
    TreeFam Gene Tree for FOXM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FOXM1 gene
    FOXO62  FOXO42  FOXO32  FOXO12  

    FOXM1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FOXM1 (see all 571)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1996326591,2
    C--2899397(+) GCAGCA/GTTTCC 10 T M mis10--------
    rs1441593701,2
    C,F--2899461(+) GGCAGG/TGTCAG 10 T P mis11Minor allele frequency- T:0.00NA 4370
    rs2011490761,2
    --2899517(+) TGGGCC/TCCTCT 10 E G mis10--------
    rs2006355861,2
    --2899536(+) CAGCTC/TCGGCT 10 K E mis10--------
    rs1146081931,2
    C,F--2899546(+) TCATCC/TACACA 10 V syn11Minor allele frequency- T:0.00NA 4552
    rs1997705991,2
    --2899630(+) TCCGAA/GACACA 10 V syn10--------
    rs1815256521,2
    C--2899670(+) ACTTCC/TTGGGT 10 K R mis10--------
    rs1412247511,2
    C--2899696(+) TGGGAC/TGAATC 10 S syn11Minor allele frequency- T:0.00NA 4552
    rs1492157401,2
    C,F--2899697(+) GGGACG/AAATCC 10 /S /L mis11Minor allele frequency- A:0.00NA 4552
    rs1388091421,2
    C,F--2899742(+) GGGCCG/AGGGAG 10 /P /L mis11Minor allele frequency- A:0.00NA 4550

    HapMap Linkage Disequilibrium report for FOXM1 (2966847 - 2986303 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FOXM1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832311CNV Loss17160897
    dgv19n68CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602341    OMIM disorders: --

    Selected diseases for FOXM1 (see all 57):    
    About MalaCards
    central pontine myelinolysis    cancer progression/metastasis    protein c deficiency    pulmonary sclerosing hemangioma
    sclerosing hemangioma    anaplastic astrocytoma    asphyxiating thoracic dystrophy    hemangioma
    achondroplasia    insulinoma    maturity-onset diabetes of the young    malignant peripheral nerve sheath tumor
    laryngeal squamous cell carcinoma    astrocytoma    pancreatic ductal adenocarcinoma    hepatitis b
    papillary thyroid carcinoma    papilloma    laryngitis    clear cell renal cell carcinoma

    4 diseases from the University of Copenhagen DISEASES database for FOXM1:
    Diabetes mellitus     Central pontine myelinolysis     maturity-onset diabetes of the young     Hepatocellular carcinoma

    FOXM1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for FOXM1 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    protein c deficiency 48.3 1 7592627 (1)
    anaplastic astrocytoma 43.9 7 18974115 (1), 17404569 (1), 16489016 (1)
    adenocarcinoma lung 42.3 2 18345025 (1), 16489016 (1)
    hepatocellular carcinoma 31.8 4 17173139 (2), 19136513 (1), 16489016 (1)
    tumor liver 27.6 1 16452231 (1)
    glioblastoma 22.9 15 16585184 (3), 18974115 (2), 17404569 (1), 16489016 (1)
    insulinoma 16.9 2 9242644 (2)
    response acute phase 14.1 2 7862129 (1)
    glioma 8.66 31 17404569 (7), 18974115 (6), 16585184 (3), 12183437 (1)
    carcinoma basal cell 7.27 2 12183437 (1), 16489016 (1)

    Genetic Association Database (GAD): FOXM1
    Human Genome Epidemiology (HuGE) Navigator: FOXM1 (2 documents)

    Export disorders for FOXM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FOXM1 gene, integrated from 10 sources (see all 290):
    (articles sorted by number of sources associating them with FOXM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues. (PubMed id 9032290)1, 2, 3, 9 Ye H.... Costa R.H. (Mol. Cell. Biol. 1997)
    2. Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain. (PubMed id 9242644)1, 2, 9 Yao K.-M.... Wong G.G. (J. Biol. Chem. 1997)
    3. The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization. (PubMed id 9441747)1, 3, 9 Korver W....Clevers H. (Genomics 1997)
    4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    5. Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression. (PubMed id 19160488)1, 2 Fu Z.... Chen J. (Nat. Cell Biol. 2008)
    6. Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes. (PubMed id 17101782)1, 2 Tan Y.... Costa R.H. (Mol. Cell. Biol. 2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope. (PubMed id 8290587)1, 2 Westendorf J.M.... Gerace L. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    9. FoxM1B transcriptionally regulates vascular endothelial growth factor expression and promotes the angiogenesis and growth of glioma cells. (PubMed id 18974115)1, 9 Zhang Y....Huang S. (Cancer Res. 2008)
    10. Critical role and regulation of transcription factor FoxM1 in human gastric cancer angiogenesis and progression. (PubMed id 19351851)1, 9 Li Q....Xie K. (Cancer Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2305 HGNC: 3818 AceView: FOXM1 Ensembl:ENSG00000111206 euGenes: HUgn2305
    ECgene: FOXM1 H-InvDB: FOXM1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FOXM1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FOXM1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/foxm1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FOXM1 gene:
    Search GeneIP for patents involving FOXM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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