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Aliases for FOXM1 Gene

Aliases for FOXM1 Gene

  • Forkhead Box M1 2 3
  • M-Phase Phosphoprotein 2 2 3 4
  • FKHL16 3 4 6
  • HFH11 3 4 6
  • Hepatocyte Nuclear Factor 3 Forkhead Homolog 11 3 4
  • Winged-Helix Factor From INS-1 Cells 3 4
  • Forkhead-Related Protein FKHL16 3 4
  • MPM-2 Reactive Phosphoprotein 2 3 4
  • Transcription Factor Trident 3 4
  • HNF-3/Fork-Head Homolog 11 3 4
  • HFH-11 3 4
  • MPP2 3 4
  • Forkhead, Drosophila, Homolog-Like 16 3
  • Forkhead Box Protein M1 3
  • MPHOSPH2 3
  • TRIDENT 3
  • FOXM1B 3
  • HNF-3 3
  • INS-1 3
  • MPP-2 3
  • PIG29 3
  • TGT3 3
  • WIN 4

External Ids for FOXM1 Gene

Previous HGNC Symbols for FOXM1 Gene

  • FKHL16

Previous GeneCards Identifiers for FOXM1 Gene

  • GC12M002839
  • GC12M002837
  • GC12M002966

Summaries for FOXM1 Gene

Entrez Gene Summary for FOXM1 Gene

  • The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

GeneCards Summary for FOXM1 Gene

FOXM1 (Forkhead Box M1) is a Protein Coding gene. Diseases associated with FOXM1 include central pontine myelinolysis and hepatocellular carcinoma. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein kinase binding. An important paralog of this gene is FOXO4.

UniProtKB/Swiss-Prot for FOXM1 Gene

  • Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response.

Tocris Summary for FOXM1 Gene

Gene Wiki entry for FOXM1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXM1 Gene

Genomics for FOXM1 Gene

Regulatory Elements for FOXM1 Gene

Genomic Location for FOXM1 Gene

Start:
2,857,681 bp from pter
End:
2,877,155 bp from pter
Size:
19,475 bases
Orientation:
Minus strand

Genomic View for FOXM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXM1 Gene

Proteins for FOXM1 Gene

  • Protein details for FOXM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08050-FOXM1_HUMAN
    Recommended name:
    Forkhead box protein M1
    Protein Accession:
    Q08050
    Secondary Accessions:
    • O43258
    • O43259
    • O43260
    • Q4ZGG7
    • Q9BRL2

    Protein attributes for FOXM1 Gene

    Size:
    763 amino acids
    Molecular mass:
    84283 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FOXM1 Gene

    Alternative splice isoforms for FOXM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXM1 Gene

Proteomics data for FOXM1 Gene at MOPED

Post-translational modifications for FOXM1 Gene

  • Phosphorylated in M (mitotic) phase. Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair. Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXM1 Gene

No data available for DME Specific Peptides for FOXM1 Gene

Domains for FOXM1 Gene

Gene Families for FOXM1 Gene

HGNC:
  • FOX :Forkhead boxes

Protein Domains for FOXM1 Gene

Suggested Antigen Peptide Sequences for FOXM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q08050

UniProtKB/Swiss-Prot:

FOXM1_HUMAN :
  • Q08050
Domain:
  • Within the protein there is a domain which acts as a transcriptional activator. Insertion of a splicing sequence within it inactivates this transcriptional activity, as it is the case for isoform 4
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXM1: view

Function for FOXM1 Gene

Molecular function for FOXM1 Gene

GENATLAS Biochemistry: transcription factor-like 16,with a Drosophila homeo forkhead DNA binding domain,mouse Trident homolog,expressed in cycling cells,involved in cell proliferation
UniProtKB/Swiss-Prot Function: Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response.
UniProtKB/Swiss-Prot Induction: Induced during liver regeneration and oxidative stress

Gene Ontology (GO) - Molecular Function for FOXM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003677 DNA binding TAS 9242644
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 9441747
GO:0005515 protein binding IPI 10523841
GO:0019901 protein kinase binding IPI 19160488
genes like me logo Genes that share ontologies with FOXM1: view
genes like me logo Genes that share phenotypes with FOXM1: view

Animal Models for FOXM1 Gene

MGI Knock Outs for FOXM1:

miRNA for FOXM1 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FOXM1 Gene

Localization for FOXM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXM1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXM1 Gene COMPARTMENTS Subcellular localization image for FOXM1 gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 2
extracellular 2
mitochondrion 2
plasma membrane 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for FOXM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with FOXM1: view

Pathways for FOXM1 Gene

genes like me logo Genes that share pathways with FOXM1: view

Pathways by source for FOXM1 Gene

Gene Ontology (GO) - Biological Process for FOXM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 20531406
GO:0000278 mitotic cell cycle TAS --
GO:0001558 regulation of cell growth TAS 10523841
GO:0001570 vasculogenesis IEA --
genes like me logo Genes that share ontologies with FOXM1: view

Compounds for FOXM1 Gene

(5) Tocris Compounds for FOXM1 Gene

Compound Action Cas Number
BI 6015 Hepatocyte nuclear factor 4alpha (HNF4alpha) antagonist [93987-29-2]
BRD 7552 PDX1 transcription factor inducer; increases insulin expression [1137359-47-7]
GANT 61 GLI antagonist; inhibits Hedgehog (Hh) signaling [500579-04-4]
KL 001 Cryptochrome protein stabilizer; lengthens circadian period [309928-48-1]
UNC 926 hydrochloride L3MBTL1 domain inhibitor [1184136-10-4]

(13) Novoseek inferred chemical compound relationships for FOXM1 Gene

Compound -log(P) Hits PubMed IDs
phosphoenolpyruvate 48.1 2
diethylnitrosamine 37.8 3
phenobarbital 26.4 2
chloramphenicol 19.7 1
12-o-tetradecanoylphorbol 13-acetate 8.87 2
genes like me logo Genes that share compounds with FOXM1: view

Transcripts for FOXM1 Gene

Unigene Clusters for FOXM1 Gene

Forkhead box M1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXM1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b
SP1: -
SP2: - - - -
SP3: - - -
SP4: - - -
SP5: - -
SP6: -
SP7: - -
SP8: - - -
SP9:
SP10:

Relevant External Links for FOXM1 Gene

GeneLoc Exon Structure for
FOXM1
ECgene alternative splicing isoforms for
FOXM1

Expression for FOXM1 Gene

mRNA expression in normal human tissues for FOXM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXM1 Gene

This gene is overexpressed in Testis (6.6) and Esophagus - Mucosa (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FOXM1 Gene

SOURCE GeneReport for Unigene cluster for FOXM1 Gene Hs.239

mRNA Expression by UniProt/SwissProt for FOXM1 Gene

Q08050-FOXM1_HUMAN
Tissue specificity: Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in testis
genes like me logo Genes that share expressions with FOXM1: view

Orthologs for FOXM1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FOXM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXM1 35
  • 98.75 (n)
  • 98.13 (a)
cow
(Bos Taurus)
Mammalia FOXM1 35
  • 82.34 (n)
  • 78.81 (a)
FOXM1 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXM1 35
  • 87.24 (n)
  • 84.01 (a)
FOXM1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxm1 35
  • 82.5 (n)
  • 80.69 (a)
Foxm1 16
Foxm1 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FOXM1 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOXM1 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxm1 35
  • 82.87 (n)
  • 81.95 (a)
chicken
(Gallus gallus)
Aves FOXM1 35
  • 60.66 (n)
  • 55.01 (a)
FOXM1 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXM1 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia foxm1 35
  • 56.02 (n)
  • 51.01 (a)
zebrafish
(Danio rerio)
Actinopterygii foxm1 35
  • 57.62 (n)
  • 53.55 (a)
foxm1 36
  • 48 (a)
OneToOne
zgc63854 35
fruit fly
(Drosophila melanogaster)
Insecta fd102C 36
  • 11 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea fkh-9 36
  • 24 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HCM1 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
OneToOne
Species with no ortholog for FOXM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FOXM1 Gene

ENSEMBL:
Gene Tree for FOXM1 (if available)
TreeFam:
Gene Tree for FOXM1 (if available)

Paralogs for FOXM1 Gene

Paralogs for FOXM1 Gene

genes like me logo Genes that share paralogs with FOXM1: view

Variants for FOXM1 Gene

Sequence variations from dbSNP and Humsavar for FOXM1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2072360 -- 2,864,449(-) CTGGT(A/G)CCTAT reference, synonymous-codon
rs2074985 -- 2,869,088(-) AAAAA(C/T)GGGCG intron-variant
rs2907506 -- 2,862,047(-) CGCAC(A/G)TCACC intron-variant
rs7294943 -- 2,872,736(+) CAGGA(A/C)AAATT intron-variant
rs7979111 -- 2,873,586(+) ttttt(A/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOXM1 Gene

Variant ID Type Subtype PubMed ID
dgv19n68 CNV Loss 17160897
nsv832311 CNV Loss 17160897

Relevant External Links for FOXM1 Gene

HapMap Linkage Disequilibrium report
FOXM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXM1 Gene

Disorders for FOXM1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for FOXM1 Gene including...

Search for FOXM1 Gene in MalaCards »

(18) Novoseek inferred disease relationships for FOXM1 Gene

Disease -log(P) Hits PubMed IDs
protein c deficiency 48.3 1
anaplastic astrocytoma 43.9 3
adenocarcinoma lung 42.3 2
hepatocellular carcinoma 31.8 4
tumor liver 27.6 1

Relevant External Links for FOXM1

Genetic Association Database (GAD)
FOXM1
Human Genome Epidemiology (HuGE) Navigator
FOXM1
genes like me logo Genes that share disorders with FOXM1: view

No data available for UniProtKB/Swiss-Prot for FOXM1 Gene

Publications for FOXM1 Gene

  1. Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues. (PMID: 9032290) Ye H. … Costa R.H. (Mol. Cell. Biol. 1997) 2 3 4 23
  2. The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization. (PMID: 9441747) Korver W. … Clevers H. (Genomics 1997) 2 3 23
  3. Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain. (PMID: 9242644) Yao K.-M. … Wong G.G. (J. Biol. Chem. 1997) 3 4 23
  4. FoxM1 is required for execution of the mitotic programme and chromosome stability. (PMID: 15654331) Laoukili J. … Medema R.H. (Nat. Cell Biol. 2005) 3 23
  5. FOXM1 is a downstream target of Gli1 in basal cell carcinomas. (PMID: 12183437) Teh M.T. … Quinn A.G. (Cancer Res. 2002) 3 23

Products for FOXM1 Gene

Sources for FOXM1 Gene

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