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Aliases for FOXL2NB Gene

Aliases for FOXL2NB Gene

  • FOXL2 Neighbor 2 3 5
  • C3orf72 3 4
  • Chromosome 3 Open Reading Frame 72 2
  • FOXL2 Neighbor Protein 3
  • FLJ43329 Protein 3

External Ids for FOXL2NB Gene

Previous HGNC Symbols for FOXL2NB Gene

  • C3orf72

Summaries for FOXL2NB Gene

GeneCards Summary for FOXL2NB Gene

FOXL2NB (FOXL2 Neighbor) is a Protein Coding gene.

Additional gene information for FOXL2NB Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXL2NB Gene

Genomics for FOXL2NB Gene

Regulatory Elements for FOXL2NB Gene

Enhancers for FOXL2NB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H138914 1.7 FANTOM5 Ensembl ENCODE 11.2 -31.4 -31379 2.5 HDGF FOXA2 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF766 CEP70 PIK3CB FAIM LINC01391 FOXL2 FOXL2NB ATP5G1P3
GH03H138923 1.1 Ensembl ENCODE 11.6 -23.6 -23564 0.3 GTF2F1 CTCF PKNOX1 RB1 ARID4B CEBPG ZNF2 RAD21 RFX5 CC2D1A LINC01391 FOXL2 FOXL2NB CEP70 FAIM ATP5G1P3
GH03H139297 1.9 FANTOM5 Ensembl ENCODE dbSUPER 1.9 +353.8 353785 7.6 HDGF FOXA2 MLX ARNT ARID4B ZNF766 ZNF143 FOS SP5 REST FOXL2NB FOXL2 PIR46128 ENSG00000272656
GH03H138948 0.8 ENCODE dbSUPER 0.7 +2.0 1952 0.9 POLR2A MAX POU5F1 CTBP2 EZH2 ETS1 FOXL2NB MRPS22
GH03H138950 0.7 ENCODE dbSUPER 0.7 +3.1 3060 0.2 SUZ12 ZBTB33 EZH2 FOXL2NB MRPS22
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FOXL2NB on UCSC Golden Path with GeneCards custom track

Genomic Locations for FOXL2NB Gene

Genomic Locations for FOXL2NB Gene
6,757 bases
Plus strand

Genomic View for FOXL2NB Gene

Genes around FOXL2NB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXL2NB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXL2NB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXL2NB Gene

Proteins for FOXL2NB Gene

  • Protein details for FOXL2NB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FOXL2 neighbor protein
    Protein Accession:
    Secondary Accessions:
    • A6NGX0

    Protein attributes for FOXL2NB Gene

    175 amino acids
    Molecular mass:
    18625 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXL2NB Gene

Post-translational modifications for FOXL2NB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXL2NB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXL2NB Gene

Domains & Families for FOXL2NB Gene

Gene Families for FOXL2NB Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FOXL2NB Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FOXL2NB: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for FOXL2NB Gene

Function for FOXL2NB Gene

Phenotypes From GWAS Catalog for FOXL2NB Gene

genes like me logo Genes that share phenotypes with FOXL2NB: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FOXL2NB Gene

Localization for FOXL2NB Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXL2NB gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FOXL2NB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
genes like me logo Genes that share ontologies with FOXL2NB: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FOXL2NB Gene

Pathways & Interactions for FOXL2NB Gene

SuperPathways for FOXL2NB Gene

No Data Available

Interacting Proteins for FOXL2NB Gene

Gene Ontology (GO) - Biological Process for FOXL2NB Gene


No data available for Pathways by source and SIGNOR curated interactions for FOXL2NB Gene

Drugs & Compounds for FOXL2NB Gene

No Compound Related Data Available

Transcripts for FOXL2NB Gene

mRNA/cDNA for FOXL2NB Gene

(2) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXL2NB Gene

No ASD Table

Relevant External Links for FOXL2NB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FOXL2NB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOXL2NB Gene

Protein differential expression in normal tissues from HIPED for FOXL2NB Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FOXL2NB Gene

Protein tissue co-expression partners for FOXL2NB Gene

NURSA nuclear receptor signaling pathways regulating expression of FOXL2NB Gene:

genes like me logo Genes that share expression patterns with FOXL2NB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXL2NB Gene

Orthologs for FOXL2NB Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for FOXL2NB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C3H3orf72 33
  • 98.86 (n)
C3orf72 34
  • 98 (a)
Species where no ortholog for FOXL2NB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FOXL2NB Gene

Gene Tree for FOXL2NB (if available)
Gene Tree for FOXL2NB (if available)

Paralogs for FOXL2NB Gene

No data available for Paralogs for FOXL2NB Gene

Variants for FOXL2NB Gene

Sequence variations from dbSNP and Humsavar for FOXL2NB Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs104893737 Pathogenic 138,946,566(-) CGGCG(C/T)AGAAG upstream-variant-2KB, reference, stop-gained
rs104893738 Pathogenic 138,945,901(-) TCGTA(C/G)AATGG upstream-variant-2KB, reference, stop-gained
rs104893739 Pathogenic 138,946,137(-) ACCTG(C/T)AGTCT upstream-variant-2KB, reference, stop-gained
rs104893741 Pathogenic 138,946,068(-) CCTGC(C/T)AGATG upstream-variant-2KB, reference, stop-gained
rs1057516139 Pathogenic 138,946,708(-) AGCTA(A/C)CCCGA upstream-variant-2KB, reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for FOXL2NB Gene

Variant ID Type Subtype PubMed ID
nsv591854 CNV gain 21841781
dgv4908n100 CNV gain 25217958

Variation tolerance for FOXL2NB Gene

Residual Variation Intolerance Score: 66.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.55; 55.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXL2NB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXL2NB Gene

Disorders for FOXL2NB Gene

Relevant External Links for FOXL2NB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FOXL2NB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXL2NB Gene

Publications for FOXL2NB Gene

  1. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 60

Products for FOXL2NB Gene

Sources for FOXL2NB Gene

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