FOXL2 Gene

Aliases
for FOXL2 gene

Previous GC identifers: GC03M135601 GC03M139464 GC03M139944 GC03M139983 GC03M140145 GC03M136038

Summaries
for FOXL2 gene

Genomic Views
for FOXL2 gene

RefSeq DNA sequence:

NC_000003.11  NC_018914.1  NT_005612.16  

SwitchGear Promoter luciferase reporter plasmid: FOXL2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXL2

FOXL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M138663:  view genomic region     (about GC identifiers)

Proteins
for FOXL2 gene

Explore the universe of human proteins at neXtProt for FOXL2: NX_P58012

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: FOXL2 OriGene Protein Over-expression Lysate: FOXL2 OriGene Custom Protein Services for FOXL2
	GenScript Custom Purified and Recombinant Proteins Services for FOXL2
	Novus Biologicals FOXL2 Protein Novus Biologicals FOXL2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for FOXL2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of FOXL2
	Browse R&D Systems for Antibodies
	OriGene Antibodies: FOXL2 OriGene Custom Antibody Services for FOXL2
	GenScript Custom Superior Antibodies Services for FOXL2
	Novus Biologicals FOXL2 Antibodies
	Search for Antibodies for FOXL2 at Abcam
	Uscn Antibodies for FOXL2
	ThermoFisher Antibodies for FOXL2

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FOXL2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FOXL2

Protein Domains /
Families
for FOXL2 gene

ProtoNet protein and cluster: P58012

Function
for FOXL2 gene

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOXL2
		8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXL2 (see all 35):
		hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-372 hsa-miR-93 hsa-miR-133a hsa-miR-23a hsa-miR-302b
		SwitchGear 3'UTR luciferase reporter plasmid: FOXL2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOXL2 (see all 4) OriGene shRNA RFP: FOXL2 OriGene siRNA: FOXL2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXL2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for FOXL2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXL2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXL2 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FOXL2 (NM_023067)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXL2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXL2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FOXL2
		Search LifeMap BioReagents cell lines for FOXL2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXL2

Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

(inferred from 6 alleles) (MGI details for Foxl2)

Pathways & Interactions
for FOXL2 gene

Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

Drugs & Compounds
for FOXL2 gene

Transcripts
for FOXL2 gene

Expression
for FOXL2 gene

FOXL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTAGACGCG

5 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	OvaryOvigerous CordOvarian Somatic Cells			Ovary
	OvaryPrimary FollicleGranulosa Cells			Ovary
	OvaryPrimordial FolliclePre-Granulosa Cells			Ovary
	OvaryAntral FollicleMature Granulosa Cells			Ovary
	BoneMaxillary Process			Bone
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOXL2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FOXL2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXL2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXL2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXL2

Orthologs
for FOXL2 gene

Paralogs
for FOXL2 gene

Paralogs for FOXL2 gene

FOXF1²  FOXA2²  FOXD4L1²  FOXF2²  FOXC2²  FOXB1²  FOXI2²  FOXE3²  

FOXC1²  FOXD4L2²  FOXQ1²  FOXD4L3²  FOXA3²  FOXD1²  FOXD3²  FOXD4L5²  

FOXD4L4²  FOXE1²  FOXL1²  FOXA1²  FOXI1²  FOXB2²  FOXD4L6²  FOXS1²  

FOXD2²  FOXD4²  

17 SIMAP similar genes for FOXL2 using alignment to 6 protein entries:     FOXL2_HUMAN (see all proteins):

FOXJ3    FOXC2    FOXK2    FOXI1    FOXA1    FOXE1

FOXA2    FOXL1    FOXC1    FOXD4    FOXI3    FOXD1

FOXG1    FOXI2    KIAA0415    FOXF1    FOXS1

FOXL2 for paralogs           About GeneDecksing

Genomic Variants
for FOXL2 gene

10/75 NCBI SNPs in FOXL2 are shown (see all 75)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs289378841,2	C	pathogenic	246817252(-)	GTACAT/GCATCG	1	--	us2k1 ese3		1		NA	2
rs1048937391,2	C	pathogenic	246817587(-)	ACCTGC/TAGTCT	1	--	us2k1		0	--	--	--	--
rs1048937411,2	C	pathogenic	246817656(-)	CCTGCC/TAGATG	1	--	us2k1		0	--	--	--	--
rs289378851,2	C	pathogenic	246817773(-)	GGCCGA/TACACA	1	--	us2k1 ese3		0	--	--	--	--
rs1048937381,2	C	pathogenic	246817823(-)	TCGTAC/GAATGG	1	--	us2k1		0	--	--	--	--
rs1142044401,2	C,F,	--	136039683(+)	TCAGGC/TCAGGG	1	--	us2k1		1		WA	118
rs794875891,2	F,	--	136041888(+)	ACGGCG/AAGGGG	1	--	int1		1		WA	118
rs732316421,2	C,F,	--	136042820(+)	TATGAG/CAGAGA	1	--	int1		1		NA	120
rs9312501,2	C,F,H,	--	136043163(-)	AGATGC/ATGAAT	1	--	int1		27		MN NS EA NA WA CSA	4397
rs133257881,2	C	--	138662610(+)	CAGAGA/GTTAGC	1	--	ds5001		0	--	--	--	--

HapMap Linkage Disequilibrium report for FOXL2 (138663066 - 138665982 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for FOXL2: --
Human Gene Mutation Database (HGMD): FOXL2

Locus Specific Mutation Databases (LSDB): FOXL2

1 SABiosciences Cancer Mutation PCR Assay for FOXL2: Cosmic Id AA Change 33661 p.C134W

2 SABiosciences Cancer Mutation PCR Arrays containing FOXL2: Ovarian Cancer   Cancer Comprehensive Panel 384HT

1 SABiosciences qBiomarker Copy Number PCR Array containing FOXL2: Birth Defects

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOXL2

DNA2.0 Custom Variant and Variant Library Synthesis for FOXL2

Disorders / Diseases
for FOXL2 gene

20/23 diseases for FOXL2

9 Novoseek disease relationships for FOXL2 gene    About this table

Publications
for FOXL2 gene

PubMed articles for FOXL2 gene, integrated from 9 sources (see all 154): (articles sorted by number of sources associating them with FOXL2)

Utopia: connect your pdf to the dynamic world of online information

1. Comparative analysis of the FOXL2 gene and characterization of mutations in BPES patients. (PubMed id 12938087)^{1, 2, 4, 9} Udar N....Small K. (2003)
2. Identification of novel mutations in FOXL2 associated with premature ovarian failure. (PubMed id 12149404)^{1, 2, 4, 9} Harris S.E....Shelling A.N. (2002)
3. The human FOXL2 mutation database. (PubMed id 15300845)^{1, 2, 9} Beysen D.... De Baere E. (2004)
4. Positive and negative feedback regulates the transcription factor FOXL2 in response to cell stress: evidence for a regulatory imbalance induced by disease-causing mutations. (PubMed id 19010791)^{1, 2, 9} Benayoun B.A.... Veitia R.A. (2009)
5. Sumoylation of forkhead L2 by Ubc9 is required for its activity as a transcriptional repressor of the Steroidogenic Acute Regulatory gene. (PubMed id 19744555)^{1, 2, 9} Kuo F.T.... Pisarska M.D. (2009)
6. Spectrum of FOXL2 gene mutations in blepharophimosis-ptosis- epicanthus inversus (BPES) families demonstrates a genotype -- phenotype correlation. (PubMed id 11468277)^{1, 2, 9} De Baere E.... Messiaen L. (2001)
7. Missense mutations in the forkhead domain of FOXL2 lead to subcellular mislocalization, protein aggregation and impaired transactivation. (PubMed id 18372316)^{1, 2, 9} Beysen D....De Baere E. (2008)
8. Mutations in the coding region of the FOXL2 gene are not a major cause of idiopathic premature ovarian failure. (PubMed id 15181179)^{1, 4, 9} Bodega B....Marozzi A. (2004)
9. Mutation of FOXL2 in granulosa-cell tumors of the ova ry. (PubMed id 19516027)^{1, 2, 9} Shah S.P....Huntsman D.G. (2009)
10. Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis. (PubMed id 16153597)^{1, 2, 9} Lee K....Bae J. (2005)

External Searches for FOXL2 gene

Genome Databases showing FOXL2 gene

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Specialized Databases showing FOXL2 gene

Products
for FOXL2 gene