Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FOXL1 Gene

Aliases for FOXL1 Gene

  • Forkhead Box L1 2 3
  • FKHL11 3 4 6
  • FREAC7 3 4 6
  • Forkhead-Related Transcription Factor 7 3 4
  • Forkhead-Related Protein FKHL11 3 4
  • FKH6 3 6
  • Forkhead Box Protein L1 3
  • Forkhead-Like 11 3
  • FREAC-7 4

External Ids for FOXL1 Gene

Previous HGNC Symbols for FOXL1 Gene

  • FKHL11

Previous GeneCards Identifiers for FOXL1 Gene

  • GC16U990020
  • GC16P087645
  • GC16P086353
  • GC16P086393
  • GC16P085169
  • GC16P086612
  • GC16P072351

Summaries for FOXL1 Gene

Entrez Gene Summary for FOXL1 Gene

  • This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors are characterized by a distinct DNA-binding forkhead domain and play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. [provided by RefSeq, Nov 2012]

GeneCards Summary for FOXL1 Gene

FOXL1 (Forkhead Box L1) is a Protein Coding gene. Diseases associated with FOXL1 include lymphedema-distichiasis syndrome and hypoplastic left heart syndrome. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and DNA binding, bending. An important paralog of this gene is FOXE3.

UniProtKB/Swiss-Prot for FOXL1 Gene

  • Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXL1 Gene

Genomics for FOXL1 Gene

Regulatory Elements for FOXL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FOXL1 Gene

Start:
86,576,368 bp from pter
End:
86,582,160 bp from pter
Size:
5,793 bases
Orientation:
Plus strand

Genomic View for FOXL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXL1 Gene

Proteins for FOXL1 Gene

  • Protein details for FOXL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12952-FOXL1_HUMAN
    Recommended name:
    Forkhead box protein L1
    Protein Accession:
    Q12952
    Secondary Accessions:
    • Q17RR1
    • Q9H242

    Protein attributes for FOXL1 Gene

    Size:
    345 amino acids
    Molecular mass:
    36490 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXL1 Gene

Proteomics data for FOXL1 Gene at MOPED

Post-translational modifications for FOXL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXL1 Gene

Domains for FOXL1 Gene

Gene Families for FOXL1 Gene

HGNC:
  • FOX :Forkhead boxes

Protein Domains for FOXL1 Gene

Suggested Antigen Peptide Sequences for FOXL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q12952

UniProtKB/Swiss-Prot:

FOXL1_HUMAN :
  • Q12952
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXL1: view

Function for FOXL1 Gene

Molecular function for FOXL1 Gene

UniProtKB/Swiss-Prot Function: Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors (By similarity).

Gene Ontology (GO) - Molecular Function for FOXL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003677 DNA binding IDA 7957066
GO:0003700 sequence-specific DNA binding transcription factor activity ISS --
GO:0008301 DNA binding, bending NAS 7957066
GO:0043565 sequence-specific DNA binding IDA 7957066
genes like me logo Genes that share ontologies with FOXL1: view
genes like me logo Genes that share phenotypes with FOXL1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FOXL1 Gene

Localization for FOXL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXL1 Gene COMPARTMENTS Subcellular localization image for FOXL1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for FOXL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IC 7957066
genes like me logo Genes that share ontologies with FOXL1: view

Pathways for FOXL1 Gene

SuperPathways for FOXL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0007275 multicellular organismal development NAS 11078474
genes like me logo Genes that share ontologies with FOXL1: view

No data available for Pathways by source for FOXL1 Gene

Transcripts for FOXL1 Gene

mRNA/cDNA for FOXL1 Gene

(3) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXL1 Gene

Forkhead box L1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOXL1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FOXL1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXL1 Gene

No ASD Table

Relevant External Links for FOXL1 Gene

GeneLoc Exon Structure for
FOXL1
ECgene alternative splicing isoforms for
FOXL1

Expression for FOXL1 Gene

mRNA expression in normal human tissues for FOXL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXL1 Gene

This gene is overexpressed in Artery - Aorta (8.3), Artery - Tibial (8.1), and Artery - Coronary (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FOXL1 Gene

SOURCE GeneReport for Unigene cluster for FOXL1 Gene Hs.533830

genes like me logo Genes that share expressions with FOXL1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FOXL1 Gene

Orthologs for FOXL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXL1 35
  • 98.74 (n)
  • 97.68 (a)
FOXL1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FOXL1 35
  • 87.15 (n)
  • 83.77 (a)
FOXL1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXL1 35
  • 88.41 (n)
  • 86.67 (a)
FOXL1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxl1 35
  • 75.9 (n)
  • 71.39 (a)
Foxl1 16
Foxl1 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FOXL1 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC687553 35
  • 75.68 (n)
  • 71.17 (a)
chicken
(Gallus gallus)
Aves FOXL1 35
  • 64.58 (n)
  • 57.76 (a)
lizard
(Anolis carolinensis)
Reptilia FOXL1 36
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii foxl1 36
  • 40 (a)
OneToOne
zgc63595 35
fruit fly
(Drosophila melanogaster)
Insecta croc 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
ManyToMany
Species with no ortholog for FOXL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXL1 Gene

ENSEMBL:
Gene Tree for FOXL1 (if available)
TreeFam:
Gene Tree for FOXL1 (if available)

Paralogs for FOXL1 Gene

Selected SIMAP similar genes for FOXL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FOXL1: view

Variants for FOXL1 Gene

Sequence variations from dbSNP and Humsavar for FOXL1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2288016 -- 86,580,977(-) AGGGG(A/G)TGCGG utr-variant-3-prime
rs3812978 -- 86,581,939(+) TTTTC(C/T)TTTTT downstream-variant-500B
rs3812979 -- 86,581,977(+) TGTTA(A/G)TTTGT downstream-variant-500B
rs4843170 -- 86,576,660(+) TGAAA(G/T)GGGTA upstream-variant-2KB
rs4843171 -- 86,576,879(+) CCTGC(C/G)ACTTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FOXL1 Gene

Variant ID Type Subtype PubMed ID
esv4262 CNV Complex 18987735
nsv525024 CNV Loss 19592680
dgv498n67 CNV Gain 20364138
dgv2947n71 CNV Loss 21882294
nsv907138 CNV Loss 21882294

Relevant External Links for FOXL1 Gene

HapMap Linkage Disequilibrium report
FOXL1
Human Gene Mutation Database (HGMD)
FOXL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXL1 Gene

Disorders for FOXL1 Gene

(1) University of Copenhagen DISEASES for FOXL1 Gene

Relevant External Links for FOXL1

Genetic Association Database (GAD)
FOXL1
Human Genome Epidemiology (HuGE) Navigator
FOXL1
genes like me logo Genes that share disorders with FOXL1: view

No data available for UniProtKB/Swiss-Prot for FOXL1 Gene

Publications for FOXL1 Gene

  1. Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. (PMID: 7957066) Pierrou S. … Carlsson P. (EMBO J. 1994) 2 3 4
  2. Mutations in FOXC2 (MFH-1), a forkhead family transcription factor, are responsible for the hereditary lymphedema-distichiasis syndrome. (PMID: 11078474) Fang J. … Glover T.W. (Am. J. Hum. Genet. 2000) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Candidate gene analysis in primary lymphedema. (PMID: 18564921) Ferrell R.E. … Finegold D.N. (Lymphat Res Biol 2008) 3 48
  5. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. (PMID: 19801982) Rivadeneira F. … Uitterlinden A.G. (Nat. Genet. 2009) 3 48

Products for FOXL1 Gene

Sources for FOXL1 Gene

Back to Top

Content