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Aliases for FOXL1 Gene

Aliases for FOXL1 Gene

  • Forkhead Box L1 2 3 5
  • Forkhead-Related Transcription Factor 7 3 4
  • Forkhead-Related Protein FKHL11 3 4
  • FKHL11 3 4
  • FREAC7 3 4
  • Forkhead-Like 11 3
  • FREAC-7 4
  • FKH6 3

External Ids for FOXL1 Gene

Previous HGNC Symbols for FOXL1 Gene

  • FKHL11

Previous GeneCards Identifiers for FOXL1 Gene

  • GC16U990020
  • GC16P087645
  • GC16P086353
  • GC16P086393
  • GC16P085169
  • GC16P086612
  • GC16P072351

Summaries for FOXL1 Gene

Entrez Gene Summary for FOXL1 Gene

  • This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors are characterized by a distinct DNA-binding forkhead domain and play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. [provided by RefSeq, Nov 2012]

GeneCards Summary for FOXL1 Gene

FOXL1 (Forkhead Box L1) is a Protein Coding gene. Diseases associated with FOXL1 include lymphedema-distichiasis syndrome and hypoplastic left heart syndrome. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXE3.

UniProtKB/Swiss-Prot for FOXL1 Gene

  • Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXL1 Gene

Genomics for FOXL1 Gene

Regulatory Elements for FOXL1 Gene

Enhancers for FOXL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FOXL1 on UCSC Golden Path with GeneCards custom track

Promoters for FOXL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FOXL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FOXL1 Gene

Chromosome:
16
Start:
86,576,368 bp from pter
End:
86,582,160 bp from pter
Size:
5,793 bases
Orientation:
Plus strand

Genomic View for FOXL1 Gene

Genes around FOXL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXL1 Gene

Proteins for FOXL1 Gene

  • Protein details for FOXL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12952-FOXL1_HUMAN
    Recommended name:
    Forkhead box protein L1
    Protein Accession:
    Q12952
    Secondary Accessions:
    • Q17RR1
    • Q9H242

    Protein attributes for FOXL1 Gene

    Size:
    345 amino acids
    Molecular mass:
    36490 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXL1 Gene

Proteomics data for FOXL1 Gene at MOPED

Post-translational modifications for FOXL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FOXL1 Gene

Domains & Families for FOXL1 Gene

Gene Families for FOXL1 Gene

Protein Domains for FOXL1 Gene

Suggested Antigen Peptide Sequences for FOXL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q12952

UniProtKB/Swiss-Prot:

FOXL1_HUMAN :
  • Contains 1 fork-head DNA-binding domain.
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXL1: view

Function for FOXL1 Gene

Molecular function for FOXL1 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors (By similarity).
genes like me logo Genes that share phenotypes with FOXL1: view

Animal Models for FOXL1 Gene

MGI Knock Outs for FOXL1:

Animal Model Products

Transcription Factor Targets for FOXL1 Gene

Selected GeneGlobe predicted Target genes for FOXL1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology and HOMER Transcription for FOXL1 Gene

Localization for FOXL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXL1 Gene COMPARTMENTS Subcellular localization image for FOXL1 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for FOXL1 Gene

Pathways & Interactions for FOXL1 Gene

SuperPathways for FOXL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development NAS 11078474
GO:0007495 visceral mesoderm-endoderm interaction involved in midgut development IEA,ISS --
GO:0009653 anatomical structure morphogenesis IBA --
GO:0009887 organ morphogenesis ISS --
genes like me logo Genes that share ontologies with FOXL1: view

No data available for Pathways by source and SIGNOR curated interactions for FOXL1 Gene

Drugs & Compounds for FOXL1 Gene

No Compound Related Data Available

Transcripts for FOXL1 Gene

mRNA/cDNA for FOXL1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXL1 Gene

Forkhead box L1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXL1 Gene

No ASD Table

Relevant External Links for FOXL1 Gene

GeneLoc Exon Structure for
FOXL1
ECgene alternative splicing isoforms for
FOXL1

Expression for FOXL1 Gene

mRNA expression in normal human tissues for FOXL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXL1 Gene

This gene is overexpressed in Artery - Aorta (x8.3), Artery - Tibial (x8.1), and Artery - Coronary (x7.4).

Protein differential expression in normal tissues from HIPED for FOXL1 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FOXL1 Gene



SOURCE GeneReport for Unigene cluster for FOXL1 Gene Hs.533830

genes like me logo Genes that share expression patterns with FOXL1: view

Protein tissue co-expression partners for FOXL1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FOXL1 Gene

Orthologs for FOXL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOXL1 35
  • 87.15 (n)
  • 83.77 (a)
FOXL1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXL1 35
  • 88.41 (n)
  • 86.67 (a)
FOXL1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxl1 35
  • 75.9 (n)
  • 71.39 (a)
Foxl1 16
Foxl1 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FOXL1 35
  • 98.74 (n)
  • 97.68 (a)
FOXL1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC687553 35
  • 75.68 (n)
  • 71.17 (a)
oppossum
(Monodelphis domestica)
Mammalia FOXL1 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOXL1 35
  • 64.58 (n)
  • 57.76 (a)
lizard
(Anolis carolinensis)
Reptilia FOXL1 36
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc63595 35
foxl1 36
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta croc 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
ManyToMany
Species with no ortholog for FOXL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXL1 Gene

ENSEMBL:
Gene Tree for FOXL1 (if available)
TreeFam:
Gene Tree for FOXL1 (if available)

Paralogs for FOXL1 Gene

(19) SIMAP similar genes for FOXL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FOXL1: view

Variants for FOXL1 Gene

Sequence variations from dbSNP and Humsavar for FOXL1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs8064031 -- 86,576,974(+) TATTT(C/G)TGATT upstream-variant-2KB
rs4843170 -- 86,576,660(+) TGAAA(G/T)GGGTA upstream-variant-2KB
rs4843171 -- 86,576,879(+) CCTGC(C/G)ACTTC upstream-variant-2KB
rs4843173 -- 86,581,663(+) TCAGC(C/T)TCTGT utr-variant-3-prime
rs4843399 -- 86,577,893(+) TCCTA(C/G)TGGGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FOXL1 Gene

Variant ID Type Subtype PubMed ID
esv4262 CNV Complex 18987735
nsv525024 CNV Loss 19592680
dgv498n67 CNV Gain 20364138
dgv2947n71 CNV Loss 21882294
nsv907138 CNV Loss 21882294

Variation tolerance for FOXL1 Gene

Residual Variation Intolerance Score: 75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.75; 33.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXL1 Gene

HapMap Linkage Disequilibrium report
FOXL1
Human Gene Mutation Database (HGMD)
FOXL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXL1 Gene

Disorders for FOXL1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for FOXL1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lymphedema-distichiasis syndrome
  • lymphedema-distichiasis syndrome with renal disease and diabetes mellitus
hypoplastic left heart syndrome
  • hlhs
hereditary lymphedema
  • milroy's disease
congenital hydrocephalus
- elite association - COSMIC cancer census association via MalaCards
Search FOXL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FOXL1

Genetic Association Database (GAD)
FOXL1
Human Genome Epidemiology (HuGE) Navigator
FOXL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXL1
genes like me logo Genes that share disorders with FOXL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOXL1 Gene

Publications for FOXL1 Gene

  1. Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. (PMID: 7957066) Pierrou S. … Carlsson P. (EMBO J. 1994) 2 3 4 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. Inhibitory effects of forkhead box L1 gene on osteosarcoma growth through the induction of cell cycle arrest and apoptosis. (PMID: 26062977) Chen X. … Wu M. (Oncol. Rep. 2015) 3
  4. Multistage genome-wide association meta-analyses identified two new loci for bone mineral density. (PMID: 24249740) Zhang L. … Deng H.W. (Hum. Mol. Genet. 2014) 3
  5. Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium. (PMID: 24430505) Moayyeri A. … Kaptoge S.K. (Hum. Mol. Genet. 2014) 3

Products for FOXL1 Gene

Sources for FOXL1 Gene

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