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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FOXL1 Gene

protein-coding   GIFtS: 51
GCID: GC16P086612

Forkhead Box L1


(Previous symbol: FKHL11)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Forkhead Box L11 2     FKH62 5
FKHL111 2 3 5     Forkhead Box Protein L12
FREAC72 3 5     Forkhead-Like 112
Forkhead-Related Protein FKHL112 3     FREAC-73
Forkhead-Related Transcription Factor 72 3     

External Ids:    HGNC: 38171   Entrez Gene: 23002   Ensembl: ENSG000001766787   OMIM: 6032525   UniProtKB: Q129523   

Export aliases for FOXL1 gene to outside databases

Previous GC identifers: GC16U990020 GC16P087645 GC16P086353 GC16P086393 GC16P085169 GC16P072351


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FOXL1 Gene:
This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX
transcription factors are characterized by a distinct DNA-binding forkhead domain and play critical roles in the
regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis.
(provided by RefSeq, Nov 2012)

GeneCards Summary for FOXL1 Gene: 
FOXL1 (forkhead box L1) is a protein-coding gene. Diseases associated with FOXL1 include lymphedema-distichiasis syndrome, and hereditary lymphedema. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOXF1.

UniProtKB/Swiss-Prot: FOXL1_HUMAN, Q12952
Function: Transcription factor required for proper proliferation and differentiation in the gastrointestinal
epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FOXL1 gene promoter:
         MyoD   PPAR-gamma2   ZID   Pax-4a   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOXL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FOXL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24   Ensembl cytogenetic band:  16q24.1   HGNC cytogenetic band: 16q24

FOXL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXL1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P086612:  view genomic region     (about GC identifiers)

Start:
86,609,974 bp from pter      End:
86,615,304 bp from pter
Size:
5,331 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FOXL1_HUMAN, Q12952 (See protein sequence)
Recommended Name: Forkhead box protein L1  
Size: 345 amino acids; 36490 Da
Subcellular location: Nucleus
Secondary accessions: Q17RR1 Q9H242

Explore the universe of human proteins at neXtProt for FOXL1: NX_Q12952

Explore proteomics data for FOXL1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q12952

  • FOXL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FOXL1 Protein Expression
    REFSEQ proteins: NP_005241.1  
    ENSEMBL proteins: 
     ENSP00000472376   ENSP00000326272  

    Human Recombinant Protein Products for FOXL1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene MassSpec for FOXL1 
    OriGene Custom Protein Services for FOXL1
    GenScript Custom Purified and Recombinant Proteins Services for FOXL1
    Novus Biologicals FOXL1 Protein
    Novus Biologicals FOXL1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FOXL1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IC7957066
    GO:0005667transcription factor complex ----

    FOXL1 for ontologies           About GeneDecksing



    FOXL1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of FOXL1
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    Abcam antibodies for FOXL1
    Cloud-Clone Corp. Antibodies for FOXL1 
    ThermoFisher Antibodies for FOXL1
    LSBio Antibodies in human, mouse, rat for FOXL1 

    Assay Products for FOXL1: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for FOXL1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FOXL1 
    Cloud-Clone Corp. CLIAs for FOXL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FOX: Forkhead boxes

    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry Q12952

    ProtoNet protein and cluster: Q12952

    UniProtKB/Swiss-Prot: FOXL1_HUMAN, Q12952
    Similarity: Contains 1 fork-head DNA-binding domain


    FOXL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOXL1_HUMAN, Q12952
    Function: Transcription factor required for proper proliferation and differentiation in the gastrointestinal
    epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors (By
    similarity)

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA7957066
    GO:0003690double-stranded DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity ISS--
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity ----
    GO:0008134transcription factor binding ----
         
    FOXL1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FOXL1:
     Increased circadian rhythm amp 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Foxl1):
     cellular  digestive/alimentary  endocrine/exocrine gland  growth/size  mortality/aging 
     tumorigenesis 

    FOXL1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FOXL1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FOXL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FOXL1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FOXL1 

    10/649 SABiosciences Target genes for FOXL1 (see all 649):
    ABCA5 ABCA8 ABCC2 ABCC5 ABHD2 ACAT1 ACOT13 ACTC1 ACVR1 ACVR2A

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOXL1
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXL1:
    hsa-miR-569 hsa-miR-485-5p hsa-miR-3163 hsa-miR-875-3p hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidFOXL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FOXL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FOXL1
    Sirion Biotech Customized adenovirus for overexpression of FOXL1

    Clone
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    OriGene clones in human, mouse for FOXL1 (see all 6)
    OriGene ORF clones in mouse, rat for FOXL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FOXL1 (NM_005250)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXL1
    Sirion Biotech Customized lentivirus for stable overexpression of FOXL1 
                         Customized lentivirus expression plasmids for stable overexpression of FOXL1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for FOXL1
    Search LifeMap BioReagents cell lines for FOXL1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXL1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOXL1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FOXL1 (Q129523 ENSP000003262724) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMPR2Q138733, ENSP000003637084I2D: score=2 STRING: ENSP00000363708
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--
    GO:0007275multicellular organismal development NAS11078474
    GO:0007389pattern specification process IBA--
    GO:0007420brain development IBA--

    FOXL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FOXL1

    Search CenterWatch for drugs/clinical trials and news about FOXL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FOXL1 gene: 
    NM_005250.2  

    Unigene Cluster for FOXL1:

    Forkhead box L1
    Hs.533830  [show with all ESTs]
    Unigene Representative Sequence: NM_005250
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000593625 ENST00000320241(uc002fjr.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOXL1
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXL1:
    hsa-miR-569 hsa-miR-485-5p hsa-miR-3163 hsa-miR-875-3p hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidFOXL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FOXL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXL1
    Clone
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    OriGene clones in human, mouse for FOXL1 (see all 6)
    OriGene ORF clones in mouse, rat for FOXL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FOXL1 (NM_005250)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXL1
    Sirion Biotech Customized lentivirus for stable overexpression of FOXL1 
                         Customized lentivirus expression plasmids for stable overexpression of FOXL1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FOXL1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FOXL1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXL1

    Additional mRNA sequence: 

    BC100027.1 BC117226.1 

    1 DOTS entry:

    DT.99946339 

    3 AceView cDNA sequences:

    CN481416 NM_005250 CO245475 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FOXL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAACCAGG
    FOXL1 Expression
    About this image


    See FOXL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FOXL1

    SOURCE GeneReport for Unigene cluster: Hs.533830
        SABiosciences Custom PCR Arrays for FOXL1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FOXL1
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FOXL1 gene from 6/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Foxl11 , 5 forkhead box L11, 5 77.64(n)1
    72.46(a)1
      8 (70.34 cM)5
    142411  NM_008024.21  NP_032050.21 
     1211279405 
    chicken
    (Gallus gallus)
    Aves FOXL11 forkhead box L1 66.11(n)
    59.14(a)
      768576  XM_001231598.2  XP_001231599.2 
    lizard
    (Anolis carolinensis)
    Reptilia FOXL16
    Uncharacterized protein
    41(a)
    1 ↔ 1
    AAWZ02040100(2561-4951)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc635952 similar to forkhead box L1 82.92(n)   393959  BC055156.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bin6
    biniou
    11(a)
    1 → many
    3L(6983722-6987544)
    worm
    (Caenorhabditis elegans)
    Secernentea let-3816
    Protein LET-381
    17(a)
    1 → many
    I(6320359-6323993)


    ENSEMBL Gene Tree for FOXL1 (if available)
    TreeFam Gene Tree for FOXL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FOXL1 gene
    FOXF12  FOXA22  FOXF22  FOXD4L12  FOXC22  FOXI22  FOXB12  FOXE32  
    FOXC12  FOXD4L22  FOXD4L32  FOXA32  FOXD4L52  FOXD12  FOXD32  FOXD4L42  
    FOXA12  FOXE12  FOXB22  FOXI12  FOXD4L62  FOXS12  FOXD22  FOXL22  
    FOXD42  
    18 SIMAP similar genes for FOXL1 using alignment to 3 protein entries:     FOXL1_HUMAN (see all proteins):
    FOXJ3    FOXN3    FOXC1    FOXP2    FOXK2    FOXC2
    FOXB1    FOXL2    FOXD1    FOXD4L2    FOXD4L3    FOXD4L4
    FOXD4L5    FOXD4L6    FOXI2    FOXE1    FOXF1    FOXA1

    FOXL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/149 SNPs in FOXL1 are shown (see all 149)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs48431701,2
    C,F--87614332(+) TGAAAG/TGGGTA 1 -- us2k17Minor allele frequency- T:0.30WA CSA NA EA 366
    rs1485054531,2
    --87614359(+) TGGTAA/GCGAAA 1 -- us2k10--------
    rs1162719351,2
    C,F--87614511(+) CGCAGG/TCAGTG 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs48431711,2
    C,A,H--87614551(+) CCTGCC/GACTTC 1 -- us2k15Minor allele frequency- G:0.21NS EA NA 536
    rs1872117051,2
    --87614590(+) CCCTGA/CGGTCT 1 -- us2k10--------
    rs1916347021,2
    --87614591(+) CCTGCA/GGTCTA 1 -- us2k10--------
    rs1428947731,2
    --87614614(+) GCTGGA/TTACCC 1 -- us2k10--------
    rs1836263271,2
    --87614636(+) ACACAC/TGGGTT 1 -- us2k10--------
    rs80640311,2
    C,F--87614646(+) TATTTC/GTGATT 1 -- us2k11Minor allele frequency- G:0.08NA 120
    rs728025431,2
    C,F--87614792(+) CCTGGC/TCCACT 1 -- us2k13Minor allele frequency- T:0.10WA NA EA 358

    HapMap Linkage Disequilibrium report for FOXL1 (86609974 - 86615304 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FOXL1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv525024CNV Loss19592680
    nsv907138CNV Loss21882294
    dgv2947n71CNV Loss21882294
    dgv498n67CNV Gain20364138
    esv4262CNV Complex18987735


    Human Gene Mutation Database (HGMD): FOXL1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FOXL1
    DNA2.0 Custom Variant and Variant Library Synthesis for FOXL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603252    OMIM disorders: --

    8 diseases for FOXL1:    About MalaCards
    lymphedema-distichiasis syndrome    hereditary lymphedema    hypoplastic left heart syndrome    vacterl association
    lymphedema    hydrocephalus    glaucoma    sarcoma

    1 disease from the University of Copenhagen DISEASES database for FOXL1:
    Hypoplastic left heart syndrome

    FOXL1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FOXL1
    Human Genome Epidemiology (HuGE) Navigator: FOXL1 (5 documents)

    Export disorders for FOXL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FOXL1 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with FOXL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. (PubMed id 7957066)1, 2, 3 Pierrou S....Carlsson P. (1994)
    2. Mutational analysis of FOXL2 codon 134 in granulosa c ell tumour of ovary and other human cancers. (PubMed id 20198651)1, 4 Kim M.S....Lee S.H. (2010)
    3. Twenty bone-mineral-density loci identified by large- scale meta-analysis of genome-wide association studies. (PubMed id 19801982)1, 4 Rivadeneira F....Uitterlinden A.G. (2009)
    4. Candidate gene analysis in primary lymphedema. (PubMed id 18564921)1, 4 Ferrell R.E....Finegold D.N. (2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Mutations in FOXC2 (MFH-1), a forkhead family transcription factor, are responsible for the hereditary lymphedema-distichiasis syndrome. (PubMed id 11078474)1, 2 Fang J.... Glover T.W. (2000)
    7. Genome-wide meta-analysis identifies 56 bone mineral d ensity loci and reveals 14 loci associated with risk of fracture. (PubMed id 22504420)1 Estrada K....Rivadeneira F. (2012)
    8. Genome-wide association analysis of age-at-onset in Al zheimer's disease. (PubMed id 22005931)4 Kamboh M.I....Lopez O.L. (2012)
    9. Identification of de novo mutations and rare variants in hypoplastic left heart syndrome. (PubMed id 21457232)1 Iascone M....Zuffardi O. (2012)
    10. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2300 HGNC: 3817 AceView: FOXL1 Ensembl:ENSG00000176678 euGenes: HUgn2300
    ECgene: FOXL1 H-InvDB: FOXL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FOXL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FOXL1 gene:
    Search GeneIP for patents involving FOXL1

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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