Aliases for FOXK2 Gene
External Ids for FOXK2 Gene
Previous HGNC Symbols for FOXK2 Gene
Previous GeneCards Identifiers for FOXK2 Gene
The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements. [provided by RefSeq, Jul 2008]
GeneCards Summary for FOXK2 Gene
FOXK2 (Forkhead Box K2) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Wnt / Hedgehog / Notch. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is FOXK1.
UniProtKB/Swiss-Prot for FOXK2 Gene
Transcriptional regulator that recognizes the core sequence 5-TAAACA-3. Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027).