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FOXK2 Gene

protein-coding   GIFtS: 52
GCID: GC17P080477

Forkhead Box K2

(Previous name: interleukin enhancer binding factor 1)
(Previous symbols: ILF, ILF1)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Forkhead Box K21 2     Interleukin Enhancer-Binding Factor 12 3
ILF11 2 3 5     FOXK12 3
ILF1 2 3     ILF-12
Interleukin Enhancer Binding Factor 11 2     Forkhead Box Protein K22
Cellular Transcription Factor ILF-12 3     

External Ids:    HGNC: 60361   Entrez Gene: 36072   Ensembl: ENSG000001415687   OMIM: 1476855   UniProtKB: Q011673   

Export aliases for FOXK2 gene to outside databases

Previous GC identifers: GC17P081157 GC17P078070 GC17P075853


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FOXK2 Gene:
The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich
motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2)
promoter. It may be involved in the regulation of viral and cellular promoter elements. (provided by RefSeq, Jul
2008)

GeneCards Summary for FOXK2 Gene:
FOXK2 (forkhead box K2) is a protein-coding gene. Diseases associated with FOXK2 include epidermodysplasia verruciformis, and brain cancer. GO annotations related to this gene include magnesium ion binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOXF1.

UniProtKB/Swiss-Prot: FOXK2_HUMAN, Q01167
Function: Recognizes the core sequence 5'-TAAACA-3'. Binds to NFAT-like motifs (purine-rich) in the IL2 promoter.
Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important
viral and cellular promoter elements

Gene Wiki entry for FOXK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010663.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FOXK2 gene promoter:
         Pax-5   AML1a   CUTL1   STAT5A   c-Ets-1   CREB   PPAR-alpha   E2F-1   E2F   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOXK2 promoter sequence
   Search Chromatin IP Primers for FOXK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FOXK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25

FOXK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXK2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P080477:  view genomic region     (about GC identifiers)

Start:
80,477,589 bp from pter      End:
80,602,538 bp from pter
Size:
124,950 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FOXK2_HUMAN, Q01167 (See protein sequence)
Recommended Name: Forkhead box protein K2  
Size: 660 amino acids; 69062 Da
Cofactor: Binds 1 magnesium ion per subunit
Sequence caution: Sequence=AAB02820.1; Type=Miscellaneous discrepancy; Note=The N-terminal sequence differs due to
frameshifts and sequencing errors; Sequence=AAB02821.1; Type=Miscellaneous discrepancy; Note=The N-terminal
sequence differs due to frameshifts and sequencing errors; Sequence=AAB02822.1; Type=Miscellaneous discrepancy;
Note=The N-terminal sequence differs due to frameshifts and sequencing errors;
2 PDB 3D structures from and Proteopedia for FOXK2:
1JXS (3D)        2C6Y (3D)    
Secondary accessions: A6NEP5 Q13622 Q13623 Q13624
Alternative splicing: 3 isoforms:  Q01167-1   Q01167-2   Q01167-3   

Explore the universe of human proteins at neXtProt for FOXK2: NX_Q01167

Explore proteomics data for FOXK2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FOXK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004505.2  
    ENSEMBL proteins: 
     ENSP00000436108   ENSP00000335677   ENSP00000433167   ENSP00000432663   ENSP00000461540  

    FOXK2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FOX: Forkhead boxes

    5 InterPro protein domains:
     IPR008984 SMAD_FHA_domain
     IPR011991 WHTH_DNA-bd_dom
     IPR000253 FHA_dom
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry Q01167

    ProtoNet protein and cluster: Q01167

    UniProtKB/Swiss-Prot: FOXK2_HUMAN, Q01167
    Domain: The C-terminal part of the DNA-binding domain may contribute to DNA recognition specificity
    Similarity: Contains 1 FHA domain
    Similarity: Contains 1 fork-head DNA-binding domain


    FOXK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOXK2_HUMAN, Q01167
    Function: Recognizes the core sequence 5'-TAAACA-3'. Binds to NFAT-like motifs (purine-rich) in the IL2 promoter.
    Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important
    viral and cellular promoter elements

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA16624804
    GO:0003700sequence-specific DNA binding transcription factor activity NAS12402362
    GO:0005515protein binding IPI--
    GO:0008301DNA binding, bending IBA--
    GO:0043565sequence-specific DNA binding IDA12402362
         
    FOXK2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FOXK2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FOXK2

    miRNA
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    miRTarBase miRNAs that target FOXK2:
    hsa-mir-425-5p (MIRT039330), hsa-mir-122-5p (MIRT023397), hsa-mir-769-5p (MIRT039207), hsa-mir-183-5p (MIRT047114), hsa-mir-18a-3p (MIRT040827)

    Block miRNA regulation of human, mouse, rat FOXK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FOXK2 (see all 87):
    hsa-miR-3607-3p hsa-miR-520e hsa-miR-106a hsa-miR-219-5p hsa-miR-519a hsa-miR-4267 hsa-miR-93 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidFOXK2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FOXK2

    Gene Editing
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FOXK2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXK2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FOXK2_HUMAN, Q01167: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    FOXK2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FOXK2 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    2Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for FOXK2
        Wnt / Hedgehog / Notch
    Cell Cycle / Checkpoint Control



    FOXK2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FOXK2
    Interactions:

        GeneGlobe Interaction Network for FOXK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FOXK2 (Q011671, 3 ENSP000003356774) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IRF2P143161, 3, ENSP000003772184EBI-2509991,EBI-2866589 I2D: score=1 STRING: ENSP00000377218
    BAP1Q925603, ENSP000004171324I2D: score=2 STRING: ENSP00000417132
    IL2P605683, ENSP000002267304I2D: score=1 STRING: ENSP00000226730
    AMOTQ4VCS53, ENSP000003610274I2D: score=2 STRING: ENSP00000361027
    DVL2O146413I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated NAS12402362
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS1909027
    GO:0007389pattern specification process IBA--
    GO:0009790embryo development IBA--

    FOXK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FOXK2

    1 HMDB Compound for FOXK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FOXK2 gene (3 alternative transcripts): 
    NM_004514.3  NM_181430.1  NM_181431.1  

    Unigene Cluster for FOXK2:

    Forkhead box K2
    Hs.591140  [show with all ESTs]
    Unigene Representative Sequence: NM_004514
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000473637(uc002kfm.1) ENST00000335255(uc002kfn.3 uc010diu.3 uc002kfo.3 uc002kfp.3)
    ENST00000527313 ENST00000570585 ENST00000531030 ENST00000526383 ENST00000571160
    ENST00000575578 ENST00000571989 ENST00000529652 ENST00000574694
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat FOXK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FOXK2 (see all 87):
    hsa-miR-3607-3p hsa-miR-520e hsa-miR-106a hsa-miR-219-5p hsa-miR-519a hsa-miR-4267 hsa-miR-93 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidFOXK2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FOXK2
    Clone
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    GenScript: all cDNA clones in your preferred vector: FOXK2 (NM_004514)
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      QuantiFast Probe-based Assays in human, mouse, rat FOXK2

    Additional mRNA sequence: 

    AK096800.1 AK123615.1 AL832570.1 BC041569.1 U58196.1 U58198.1 

    24 DOTS entries:

    DT.100030956  DT.100834914  DT.453237  DT.100834912  DT.100834910  DT.87078921  DT.429753  DT.97855775 
    DT.100834900  DT.92438886  DT.121642875  DT.92000945  DT.92438897  DT.121012666  DT.92024960  DT.100834904 
    DT.121012697  DT.121012736  DT.417838  DT.91944169  DT.92428539  DT.95143028  DT.100642716  DT.95142978 

    Selected AceView cDNA sequences (see all 138):

    BM791223 BQ950047 BF765809 NM_181430 BQ055029 CA945143 H96280 CR620815 
    CF128609 AI783667 BQ057808 BQ221208 BX115616 AA378572 BG682076 BQ053739 
    NM_181431 BX472666 BQ232345 BM744062 AL555260 NM_004514 AW500319 H19815 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FOXK2    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b · 13c
    SP1:        -     -     -                                               -     -     -     -     -                     
    SP2:                    -                                                                                             
    SP3:                                                                                                                  
    SP4:                                                                                                                  
    SP5:                                                                                -     -     -                     


    ECgene alternative splicing isoforms for FOXK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FOXK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAACCTTGAG
    FOXK2 Expression
    About this image


    FOXK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    FOXK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FOXK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591140

    UniProtKB/Swiss-Prot: FOXK2_HUMAN, Q01167
    Tissue specificity: Expressed in both lymphoid and non-lymphoid cells

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FOXK2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Foxk21 , 5 forkhead box K21, 5 86.89(n)1
    93.9(a)1
      11 (85.15 cM)5
    688371  NM_001080932.21  NP_001074401.21 
     1212599905 
    chicken
    (Gallus gallus)
    Aves FOXK21 forkhead box K2 79.81(n)
    87.85(a)
      427798  XM_425369.4  XP_425369.4 
    lizard
    (Anolis carolinensis)
    Reptilia FOXK26
    forkhead box K2
    85(a)
    1 ↔ 1
    2(103611235-103656927)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.232532 Xenopus laevis, Similar to forkhead box K1, clone IMAGE488965 more 80.05(n)    BC046369.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CA476725.12   -- 79.43(n)   324141  CA476725.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fd68A6
    forkhead domain 68A
    27(a)
    1 → many
    3L(11107269-11113875)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FKH16
    FKH26
    Forkhead family transcription factor with a minor ...
    Forkhead family transcription factor with a major ...
    15(a)
    12(a)
    many ↔ many
    many ↔ many
    IX(100781-102235) YIL131C
    XIV(495701-498289) YNL068C


    ENSEMBL Gene Tree for FOXK2 (if available)
    TreeFam Gene Tree for FOXK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FOXK2 gene
    FOXF12  FOXQ12  FOXN32  FOXJ12  FOXF22  FOXK12  FOXN42  FOXR12  
    FOXH12  FOXN12  FOXJ32  FOXG12  FOXJ22  FOXN22  FOXR22  
    9 SIMAP similar genes for FOXK2 using alignment to 4 protein entries:     FOXK2_HUMAN (see all proteins):
    FOXJ3    FOXK1    FOXC2    FOXN4    KIAA0415    FOXL1
    FOXL2    FOXN3    FOXC1

    FOXK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FOXK2 (see all 2372)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2004511371,2
    Cuntested180521349(+) CATCTC/TGCCCC 2 S L mis10--------
    rs794386931,2
    C,F--80475598(+) CGTGCC/GAGGCC 1 -- us2k11Minor allele frequency- G:0.03NA 120
    rs557679531,2
    C--80475746(+) AGGAA-/CCACCA 1 -- us2k10--------
    rs358498091,2
    C--80475796(+) CCAGC-/AGAGACT 1 -- us2k10--------
    rs105349201,2
    C--80475797(+) GCAGA-/GACTAAA 1 -- us2k10--------
    rs1932339711,2
    --80475846(+) ATGCGC/TGCTTG 1 -- us2k10--------
    rs728591951,2
    C,F--80475999(+) TTTCTT/CTCTTT 1 -- us2k11Minor allele frequency- C:0.15NA 120
    rs1176078731,2
    C,F--80476066(+) CTGGAG/AGGCAG 1 -- us2k11Minor allele frequency- A:0.12NA 120
    rs1128914741,2
    C,F--80476078(+) GGCGTG/CATGTC 1 -- us2k11Minor allele frequency- C:0.50NA 2
    rs1157330561,2
    C--80476470(+) CTATTC/TGTTCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FOXK2 (80477589 - 80602538 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FOXK2 (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716509CNV Deletion23290073
    esv2716510CNV Deletion23290073
    esv2716506CNV Deletion23290073
    esv1003878CNV Deletion20482838
    esv2716508CNV Deletion23290073
    esv2716505CNV Deletion23290073
    nsv166CNV Insertion15895083
    nsv2167CNV Insertion18451855
    esv991816CNV Insertion20482838
    nsv509678CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FOXK2
    DNA2.0 Custom Variant and Variant Library Synthesis for FOXK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147685    OMIM disorders: --

    6 diseases for FOXK2:    
    About MalaCards
    epidermodysplasia verruciformis    brain cancer    tonsillitis    hiv-1
    thyroiditis    cerebritis

    1 disease from the University of Copenhagen DISEASES database for FOXK2:
    Epidermodysplasia verruciformis

    FOXK2 for disorders           About GeneDecksing


    Export disorders for FOXK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FOXK2 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with FOXK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Solution structure of the DNA-binding domain of interleukin enhancer binding factor 1 (FOXK1a). (PubMed id 12402362)1, 2, 9 Liu P.-P.... Chuang W.-J. (Proteins 2002)
    2. Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein ILF. (PubMed id 1339390)1, 2, 9 Li C.... Gaynor R.B. (Genomics 1992)
    3. Crystal structure of the human FOXK1a-DNA complex and its implications on the diverse binding specificity of winged helix/forkhead proteins. (PubMed id 16624804)1, 2, 9 Tsai K.-L....Hsiao C.-D. (J. Biol. Chem. 2006)
    4. Cloning of a cellular factor, interleukin binding factor, that binds to NFAT-like motifs in the human immunodeficiency virus long terminal repeat. (PubMed id 1909027)1, 2, 9 Li C.... Gaynor R.B. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)1, 2 Zody M.C.... Nusbaum C. (Nature 2006)
    6. Characterization of antigen receptor response elements within the interleukin-2 enhancer. (PubMed id 3260003)1, 3 Durand D.B....Crabtree G.R. (Mol. Cell. Biol. 1988)
    7. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    8. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    9. The forkhead transcription factor FOXK2 promotes AP-1-mediated transcriptional regulation. (PubMed id 22083952)1 Ji Z....Sharrocks A.D. (Mol. Cell. Biol. 2012)
    10. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3607 HGNC: 6036 AceView: FOXK2 Ensembl:ENSG00000141568 euGenes: HUgn3607
    ECgene: FOXK2 H-InvDB: FOXK2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FOXK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FOXK2 gene:
    Search GeneIP for patents involving FOXK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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