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Aliases for FOXK2 Gene

Aliases for FOXK2 Gene

  • Forkhead Box K2 2 3 5
  • Interleukin Enhancer Binding Factor 1 2 3
  • Interleukin Enhancer-Binding Factor 1 3 4
  • Cellular Transcription Factor ILF-1 3 4
  • FOXK1 3 4
  • ILF1 3 4
  • ILF 3 4
  • ILF-1 3

External Ids for FOXK2 Gene

Previous HGNC Symbols for FOXK2 Gene

  • ILF
  • ILF1

Previous GeneCards Identifiers for FOXK2 Gene

  • GC17P081157
  • GC17P078070
  • GC17P080477
  • GC17P075853

Summaries for FOXK2 Gene

Entrez Gene Summary for FOXK2 Gene

  • The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXK2 Gene

FOXK2 (Forkhead Box K2) is a Protein Coding gene. Among its related pathways are DNA Damage and Wnt / Hedgehog / Notch. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is FOXP3.

UniProtKB/Swiss-Prot for FOXK2 Gene

  • Recognizes the core sequence 5-TAAACA-3. Binds to NFAT-like motifs (purine-rich) in the IL2 promoter. Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements.

Gene Wiki entry for FOXK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXK2 Gene

Genomics for FOXK2 Gene

Regulatory Elements for FOXK2 Gene

Enhancers for FOXK2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FOXK2 on UCSC Golden Path with GeneCards custom track

Promoters for FOXK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FOXK2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FOXK2 Gene

Chromosome:
17
Start:
82,519,713 bp from pter
End:
82,644,662 bp from pter
Size:
124,950 bases
Orientation:
Plus strand

Genomic View for FOXK2 Gene

Genes around FOXK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXK2 Gene

Proteins for FOXK2 Gene

  • Protein details for FOXK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01167-FOXK2_HUMAN
    Recommended name:
    Forkhead box protein K2
    Protein Accession:
    Q01167
    Secondary Accessions:
    • A6NEP5
    • Q13622
    • Q13623
    • Q13624

    Protein attributes for FOXK2 Gene

    Size:
    660 amino acids
    Molecular mass:
    69062 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB02820.1; Type=Miscellaneous discrepancy; Note=The N-terminal sequence differs due to frameshifts and sequencing errors.; Evidence={ECO:0000305}; Sequence=AAB02821.1; Type=Miscellaneous discrepancy; Note=The N-terminal sequence differs due to frameshifts and sequencing errors.; Evidence={ECO:0000305}; Sequence=AAB02822.1; Type=Miscellaneous discrepancy; Note=The N-terminal sequence differs due to frameshifts and sequencing errors.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FOXK2 Gene

    Alternative splice isoforms for FOXK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXK2 Gene

Proteomics data for FOXK2 Gene at MOPED

Post-translational modifications for FOXK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXK2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FOXK2 (FOXK2)

No data available for DME Specific Peptides for FOXK2 Gene

Domains & Families for FOXK2 Gene

Gene Families for FOXK2 Gene

Suggested Antigen Peptide Sequences for FOXK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q01167

UniProtKB/Swiss-Prot:

FOXK2_HUMAN :
  • The C-terminal part of the DNA-binding domain may contribute to DNA recognition specificity.
Domain:
  • The C-terminal part of the DNA-binding domain may contribute to DNA recognition specificity.
  • Contains 1 FHA domain.
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXK2: view

Function for FOXK2 Gene

Molecular function for FOXK2 Gene

UniProtKB/Swiss-Prot Function:
Recognizes the core sequence 5-TAAACA-3. Binds to NFAT-like motifs (purine-rich) in the IL2 promoter. Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements.

Gene Ontology (GO) - Molecular Function for FOXK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 16624804
GO:0005515 protein binding IEA,IPI 21903422
genes like me logo Genes that share ontologies with FOXK2: view
genes like me logo Genes that share phenotypes with FOXK2: view

Animal Model Products

miRNA for FOXK2 Gene

miRTarBase miRNAs that target FOXK2
Targeted motifs for FOXK2 Gene
HOMER Transcription Factor Regulatory Elements motif FOXK2
  • Consensus sequence: SCHTGTTTACAT Submotif: canonical Cell Type: U2OS

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for FOXK2 Gene

Localization for FOXK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXK2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXK2 Gene COMPARTMENTS Subcellular localization image for FOXK2 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for FOXK2 Gene

Pathways & Interactions for FOXK2 Gene

SuperPathways for FOXK2 Gene

genes like me logo Genes that share pathways with FOXK2: view

Pathways by source for FOXK2 Gene

2 Cell Signaling Technology pathways for FOXK2 Gene

SIGNOR curated interactions for FOXK2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for FOXK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,NAS 12402362
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with FOXK2: view

Drugs & Compounds for FOXK2 Gene

(1) Drugs for FOXK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Nutra 0
genes like me logo Genes that share compounds with FOXK2: view

Transcripts for FOXK2 Gene

Unigene Clusters for FOXK2 Gene

Forkhead box K2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXK2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - - - - - - - -
SP2: -
SP3:
SP4:
SP5: - - -

Relevant External Links for FOXK2 Gene

GeneLoc Exon Structure for
FOXK2
ECgene alternative splicing isoforms for
FOXK2

Expression for FOXK2 Gene

mRNA expression in normal human tissues for FOXK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FOXK2 Gene

This gene is overexpressed in Heart (27.5) and Pancreatic juice (17.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FOXK2 Gene



SOURCE GeneReport for Unigene cluster for FOXK2 Gene Hs.591140

mRNA Expression by UniProt/SwissProt for FOXK2 Gene

Q01167-FOXK2_HUMAN
Tissue specificity: Expressed in both lymphoid and non-lymphoid cells.
genes like me logo Genes that share expression patterns with FOXK2: view

Protein tissue co-expression partners for FOXK2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for FOXK2 Gene

Orthologs for FOXK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FOXK2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOXK2 35
  • 88.56 (n)
  • 93.01 (a)
FOXK2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXK2 35
  • 88.32 (n)
  • 93.42 (a)
FOXK2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxk2 35
  • 86.89 (n)
  • 93.9 (a)
Foxk2 16
Foxk2 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FOXK2 35
  • 99.54 (n)
  • 99.85 (a)
FOXK2 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FOXK2 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOXK2 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOXK2 35
  • 79.81 (n)
  • 87.85 (a)
FOXK2 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXK2 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia foxk2 35
  • 77.28 (n)
  • 84.25 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23253 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
si:ch211-262e15.1 35
  • 74.73 (n)
  • 80.6 (a)
foxk2 36
  • 76 (a)
OneToMany
FOXK2 (1 of 2) 36
  • 76 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta fd68A 36
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FKH1 36
  • 15 (a)
ManyToMany
FKH2 36
  • 12 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2618 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9506 36
  • 38 (a)
OneToMany
Species with no ortholog for FOXK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXK2 Gene

ENSEMBL:
Gene Tree for FOXK2 (if available)
TreeFam:
Gene Tree for FOXK2 (if available)

Paralogs for FOXK2 Gene

(9) SIMAP similar genes for FOXK2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FOXK2: view

Variants for FOXK2 Gene

Sequence variations from dbSNP and Humsavar for FOXK2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs4822 -- 82,602,618(+) GGCAC(A/G)TCTGG utr-variant-3-prime
rs8795 -- 82,602,545(+) TGACC(C/T)GCTGT utr-variant-3-prime
rs13382 -- 82,603,877(+) ATATC(A/G)AAGCG utr-variant-3-prime
rs15153 -- 82,604,511(+) TTCTA(A/G)AAAGT utr-variant-3-prime
rs923199 -- 82,537,310(+) AATAA(A/C/T)ACTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOXK2 Gene

Variant ID Type Subtype PubMed ID
nsv428351 CNV Gain 18775914
dgv3332n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
dgv3354n71 CNV Loss 21882294
nsv909229 CNV Loss 21882294
dgv3360n71 CNV Loss 21882294
nsv833574 CNV Gain 17160897
dgv3361n71 CNV Loss 21882294
nsv909237 CNV Loss 21882294
nsv909238 CNV Loss 21882294
esv1003878 CNV Deletion 20482838
esv2716505 CNV Deletion 23290073
esv2716506 CNV Deletion 23290073
nsv909239 CNV Gain 21882294
nsv509678 CNV Insertion 20534489
nsv2167 CNV Insertion 18451855
nsv166 CNV Insertion 15895083
nsv909240 CNV Loss 21882294
dgv3363n71 CNV Loss 21882294
esv2716508 CNV Deletion 23290073
esv2716509 CNV Deletion 23290073
esv991816 CNV Insertion 20482838
esv2716510 CNV Deletion 23290073
nsv828145 CNV Gain 20364138

Variation tolerance for FOXK2 Gene

Residual Variation Intolerance Score: 36.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.01; 60.26% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FOXK2 Gene

Disorders for FOXK2 Gene

Relevant External Links for FOXK2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXK2

No disorders were found for FOXK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXK2 Gene

Publications for FOXK2 Gene

  1. Solution structure of the DNA-binding domain of interleukin enhancer binding factor 1 (FOXK1a). (PMID: 12402362) Liu P.-P. … Chuang W.-J. (Proteins 2002) 3 4 23 67
  2. Crystal structure of the human FOXK1a-DNA complex and its implications on the diverse binding specificity of winged helix/forkhead proteins. (PMID: 16624804) Tsai K.-L. … Hsiao C.-D. (J. Biol. Chem. 2006) 3 23
  3. Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein ILF. (PMID: 1339390) Li C. … Gaynor R.B. (Genomics 1992) 3 23
  4. Cloning of a cellular factor, interleukin binding factor, that binds to NFAT-like motifs in the human immunodeficiency virus long terminal repeat. (PMID: 1909027) Li C. … Gaynor R.B. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 23
  5. Characterization of antigen receptor response elements within the interleukin-2 enhancer. (PMID: 3260003) Durand D.B. … Crabtree G.R. (Mol. Cell. Biol. 1988) 2 3

Products for FOXK2 Gene

Sources for FOXK2 Gene

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