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Aliases for FOXK2 Gene

Aliases for FOXK2 Gene

  • Forkhead Box K2 2 3 5
  • Interleukin Enhancer-Binding Factor 1 3 4
  • Cellular Transcription Factor ILF-1 3 4
  • FOXK1 3 4
  • ILF1 3 4
  • ILF 3 4
  • Interleukin Enhancer Binding Factor 1 2
  • Forkhead Box Protein K2 3
  • ILF-1 3

External Ids for FOXK2 Gene

Previous HGNC Symbols for FOXK2 Gene

  • ILF
  • ILF1

Previous GeneCards Identifiers for FOXK2 Gene

  • GC17P081157
  • GC17P078070
  • GC17P080477
  • GC17P075853

Summaries for FOXK2 Gene

Entrez Gene Summary for FOXK2 Gene

  • The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXK2 Gene

FOXK2 (Forkhead Box K2) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Wnt / Hedgehog / Notch. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is FOXK1.

UniProtKB/Swiss-Prot for FOXK2 Gene

  • Transcriptional regulator that recognizes the core sequence 5-TAAACA-3. Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027).

Gene Wiki entry for FOXK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXK2 Gene

Genomics for FOXK2 Gene

Regulatory Elements for FOXK2 Gene

Enhancers for FOXK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F082518 1.1 ENCODE 8.6 +1.2 1244 4.7 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 HGS ENSG00000262049 ENSG00000262652 ARL2BPP9 ALYREF NARF-IT1 OGFOD3 ENSG00000265678 SIRT7 CCDC137
GH17F082533 1.6 FANTOM5 Ensembl ENCODE 5.3 +17.6 17588 7.8 HDGF PKNOX1 ARID4B SIN3A GLIS2 KLF7 FOS ZNF263 TBX21 NFIL3 NARF C17orf62 TEX19 SECTM1 FOXK2 ENSG00000264812 GC17M082549
GH17F083079 1.8 FANTOM5 Ensembl ENCODE 4.6 +566.1 566131 13.4 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 SLC30A9 ZNF766 FOS DEK ENSG00000261888 ENSG00000265678 METRNL B3GNTL1 ENSG00000262663 NARF LOC101929552 FOXK2 PIR48502
GH17F082492 1.9 FANTOM5 Ensembl ENCODE 3.7 -23.7 -23709 7.0 CREB3L1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 SP3 NARF ARL2BPP9 ALYREF ENSG00000262049 OGFOD3 ENSG00000262652 HGS LOC105371942 NARF-IT1 SECTM1
GH17F082551 1.3 Ensembl ENCODE 5 +33.7 33741 4.1 PKNOX1 ZFP64 SIN3A ARID4B YBX1 ZNF2 ZNF121 GLIS2 ZNF143 ZNF207 ENSG00000262049 ENSG00000262663 OGFOD3 TEX19 FOXK2 ENSG00000264812 GC17M082549 ARL2BPP9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FOXK2 on UCSC Golden Path with GeneCards custom track

Promoters for FOXK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001355734 787 3401 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for FOXK2 Gene

Chromosome:
17
Start:
82,519,713 bp from pter
End:
82,644,662 bp from pter
Size:
124,950 bases
Orientation:
Plus strand

Genomic View for FOXK2 Gene

Genes around FOXK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXK2 Gene

Proteins for FOXK2 Gene

  • Protein details for FOXK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01167-FOXK2_HUMAN
    Recommended name:
    Forkhead box protein K2
    Protein Accession:
    Q01167
    Secondary Accessions:
    • A6NEP5
    • Q13622
    • Q13623
    • Q13624

    Protein attributes for FOXK2 Gene

    Size:
    660 amino acids
    Molecular mass:
    69062 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with DVL1, DVL2 (when phosphorylated) and DVL3; the interaction induces DVL2 nuclear translocation (PubMed:25805136). Interacts with SUDS3 (PubMed:25805136).
    SequenceCaution:
    • Sequence=AAB02820.1; Type=Miscellaneous discrepancy; Note=The N-terminal sequence differs due to frameshifts and sequencing errors.; Evidence={ECO:0000305}; Sequence=AAB02821.1; Type=Miscellaneous discrepancy; Note=The N-terminal sequence differs due to frameshifts and sequencing errors.; Evidence={ECO:0000305}; Sequence=AAB02822.1; Type=Miscellaneous discrepancy; Note=The N-terminal sequence differs due to frameshifts and sequencing errors.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FOXK2 Gene

    Alternative splice isoforms for FOXK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXK2 Gene

Post-translational modifications for FOXK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXK2 Gene

No data available for DME Specific Peptides for FOXK2 Gene

Domains & Families for FOXK2 Gene

Gene Families for FOXK2 Gene

Suggested Antigen Peptide Sequences for FOXK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q01167

UniProtKB/Swiss-Prot:

FOXK2_HUMAN :
  • The C-terminal part of the DNA-binding domain may contribute to DNA recognition specificity.
Domain:
  • The C-terminal part of the DNA-binding domain may contribute to DNA recognition specificity.
  • Contains 1 FHA domain.
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXK2: view

Function for FOXK2 Gene

Molecular function for FOXK2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator that recognizes the core sequence 5-TAAACA-3. Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027).

Gene Ontology (GO) - Molecular Function for FOXK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 16624804
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 9065434
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 9065434
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 12402362
genes like me logo Genes that share ontologies with FOXK2: view
genes like me logo Genes that share phenotypes with FOXK2: view

Animal Model Products

miRNA for FOXK2 Gene

miRTarBase miRNAs that target FOXK2
Targeted motifs for FOXK2 Gene
HOMER Transcription Factor Regulatory Elements motif FOXK2
  • Consensus sequence: SCHTGTTTACAT Submotif: canonical Cell Type: U2OS

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for FOXK2 Gene

Localization for FOXK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXK2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXK2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for FOXK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IC 1909027
GO:0005654 nucleoplasm IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with FOXK2: view

Pathways & Interactions for FOXK2 Gene

genes like me logo Genes that share pathways with FOXK2: view

Pathways by source for FOXK2 Gene

2 Cell Signaling Technology pathways for FOXK2 Gene

SIGNOR curated interactions for FOXK2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for FOXK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 12402362
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 1909027
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 9065434
genes like me logo Genes that share ontologies with FOXK2: view

Drugs & Compounds for FOXK2 Gene

(1) Drugs for FOXK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Nutra 0
genes like me logo Genes that share compounds with FOXK2: view

Transcripts for FOXK2 Gene

Unigene Clusters for FOXK2 Gene

Forkhead box K2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXK2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - - - - - - - -
SP2: -
SP3:
SP4:
SP5: - - -

Relevant External Links for FOXK2 Gene

GeneLoc Exon Structure for
FOXK2
ECgene alternative splicing isoforms for
FOXK2

Expression for FOXK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FOXK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FOXK2 Gene

This gene is overexpressed in Heart (27.5) and Pancreatic juice (17.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FOXK2 Gene



Protein tissue co-expression partners for FOXK2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FOXK2 Gene:

FOXK2

SOURCE GeneReport for Unigene cluster for FOXK2 Gene:

Hs.591140

mRNA Expression by UniProt/SwissProt for FOXK2 Gene:

Q01167-FOXK2_HUMAN
Tissue specificity: Expressed in both lymphoid and non-lymphoid cells.
genes like me logo Genes that share expression patterns with FOXK2: view

Primer Products

No data available for mRNA differential expression in normal tissues for FOXK2 Gene

Orthologs for FOXK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FOXK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXK2 34 35
  • 99.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FOXK2 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FOXK2 34 35
  • 88.56 (n)
dog
(Canis familiaris)
Mammalia FOXK2 34 35
  • 88.32 (n)
mouse
(Mus musculus)
Mammalia Foxk2 34 16 35
  • 86.89 (n)
oppossum
(Monodelphis domestica)
Mammalia FOXK2 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOXK2 34 35
  • 79.81 (n)
lizard
(Anolis carolinensis)
Reptilia FOXK2 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia foxk2 34
  • 77.28 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23253 34
zebrafish
(Danio rerio)
Actinopterygii foxk2 35
  • 76 (a)
OneToMany
FOXK2 (1 of 2) 35
  • 76 (a)
OneToMany
si:ch211-262e15.1 34
  • 74.73 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta fd68A 35
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FKH1 35
  • 15 (a)
ManyToMany
FKH2 35
  • 12 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9506 35
  • 38 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2618 34
Species where no ortholog for FOXK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXK2 Gene

ENSEMBL:
Gene Tree for FOXK2 (if available)
TreeFam:
Gene Tree for FOXK2 (if available)

Paralogs for FOXK2 Gene

(9) SIMAP similar genes for FOXK2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FOXK2: view

Variants for FOXK2 Gene

Sequence variations from dbSNP and Humsavar for FOXK2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1051848 -- 82,603,887(-) TTACT(A/G)CTCTC nc-transcript-variant, utr-variant-3-prime
rs1051855 -- 82,603,448(-) AGCTC(A/G)AGAGC nc-transcript-variant, utr-variant-3-prime
rs10534920 -- 82,517,923(+) GCAGA(-/GA)CTAAA upstream-variant-2KB
rs10545272 -- 82,573,526(+) TACAT(-/AC)ACACA intron-variant
rs10558425 -- 82,561,917(+) GGGGG(-/G)TGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOXK2 Gene

Variant ID Type Subtype PubMed ID
nsv833574 CNV gain 17160897
nsv828145 CNV gain 20364138
nsv509678 CNV insertion 20534489
nsv428351 CNV gain 18775914
nsv2167 CNV insertion 18451855
nsv166 CNV insertion 15895083
nsv1160502 CNV deletion 26073780
nsv1149543 CNV insertion 26484159
nsv1135833 CNV deletion 24896259
nsv1132879 CNV insertion 24896259
nsv1123151 CNV deletion 24896259
nsv1072762 CNV deletion 25765185
nsv1067553 CNV loss 25217958
nsv1067362 CNV gain 25217958
nsv1067194 CNV gain 25217958
nsv1062980 CNV gain 25217958
nsv1056818 CNV gain 25217958
esv991816 CNV insertion 20482838
esv3641431 CNV loss 21293372
esv3641430 CNV loss 21293372
esv3641429 CNV loss 21293372
esv3554907 CNV deletion 23714750
esv3554906 CNV deletion 23714750
esv3431063 CNV duplication 20981092
esv3380953 CNV duplication 20981092
esv3324955 CNV insertion 20981092
esv2762577 CNV gain+loss 21179565
esv2716510 CNV deletion 23290073
esv2716509 CNV deletion 23290073
esv2716508 CNV deletion 23290073
esv2716506 CNV deletion 23290073
esv2716505 CNV deletion 23290073
esv21913 CNV gain+loss 19812545
esv1003878 CNV deletion 20482838
dgv1527n106 CNV tandem duplication 24896259
dgv1526n106 CNV deletion 24896259

Variation tolerance for FOXK2 Gene

Residual Variation Intolerance Score: 36.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.01; 60.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXK2 Gene

Disorders for FOXK2 Gene

Relevant External Links for FOXK2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXK2

No disorders were found for FOXK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXK2 Gene

Publications for FOXK2 Gene

  1. Crystal structure of the human FOXK1a-DNA complex and its implications on the diverse binding specificity of winged helix/forkhead proteins. (PMID: 16624804) Tsai K.-L. … Hsiao C.-D. (J. Biol. Chem. 2006) 3 4 22 64
  2. Solution structure of the DNA-binding domain of interleukin enhancer binding factor 1 (FOXK1a). (PMID: 12402362) Liu P.-P. … Chuang W.-J. (Proteins 2002) 3 4 22 64
  3. Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein ILF. (PMID: 1339390) Li C. … Gaynor R.B. (Genomics 1992) 3 4 22 64
  4. Cloning of a cellular factor, interleukin binding factor, that binds to NFAT-like motifs in the human immunodeficiency virus long terminal repeat. (PMID: 1909027) Li C. … Gaynor R.B. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 4 22 64
  5. FOXKs promote Wnt/I^-catenin signaling by translocating DVL into the nucleus. (PMID: 25805136) Wang W. … Chen J. (Dev. Cell 2015) 3 4 64

Products for FOXK2 Gene

Sources for FOXK2 Gene

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