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Aliases for FOXK2 Gene

Aliases for FOXK2 Gene

  • Forkhead Box K2 2 3
  • ILF1 3 4 6
  • Interleukin Enhancer Binding Factor 1 2 3
  • Interleukin Enhancer-Binding Factor 1 3 4
  • Cellular Transcription Factor ILF-1 3 4
  • FOXK1 3 4
  • ILF 3 4
  • Forkhead Box Protein K2 3
  • ILF-1 3

External Ids for FOXK2 Gene

Previous Symbols for FOXK2 Gene

  • ILF
  • ILF1

Summaries for FOXK2 Gene

Entrez Gene Summary for FOXK2 Gene

  • The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXK2 Gene

FOXK2 (Forkhead Box K2) is a Protein Coding gene. Among its related pathways are Cell Cycle / Checkpoint Control and Wnt / Hedgehog / Notch. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and magnesium ion binding. An important paralog of this gene is FOXJ2.

UniProtKB/Swiss-Prot for FOXK2 Gene

  • Recognizes the core sequence 5-TAAACA-3. Binds to NFAT-like motifs (purine-rich) in the IL2 promoter. Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements.

Gene Wiki entry for FOXK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXK2 Gene

Genomics for FOXK2 Gene

Genomic Location for FOXK2 Gene

Start:
82,519,713 bp from pter
End:
82,644,662 bp from pter
Size:
124,950 bases
Orientation:
Plus strand

Genomic View for FOXK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXK2 Gene

Regulatory Elements for FOXK2 Gene

Proteins for FOXK2 Gene

  • Protein details for FOXK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01167-FOXK2_HUMAN
    Recommended name:
    Forkhead box protein K2
    Protein Accession:
    Q01167
    Secondary Accessions:
    • A6NEP5
    • Q13622
    • Q13623
    • Q13624

    Protein attributes for FOXK2 Gene

    Size:
    660 amino acids
    Molecular mass:
    69062 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB02820.1; Type=Miscellaneous discrepancy; Note=The N-terminal sequence differs due to frameshifts and sequencing errors.; Evidence={ECO:0000305}; Sequence=AAB02821.1; Type=Miscellaneous discrepancy; Note=The N-terminal sequence differs due to frameshifts and sequencing errors.; Evidence={ECO:0000305}; Sequence=AAB02822.1; Type=Miscellaneous discrepancy; Note=The N-terminal sequence differs due to frameshifts and sequencing errors.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FOXK2 Gene

    Alternative splice isoforms for FOXK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXK2 Gene

Proteomics data for FOXK2 Gene at MOPED

Post-translational modifications for FOXK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXK2 Gene

No data available for DME Specific Peptides for FOXK2 Gene

Domains for FOXK2 Gene

Gene Families for FOXK2 Gene

HGNC:
  • FOX :Forkhead boxes

Protein Domains for FOXK2 Gene

Suggested Antigen Peptide Sequences for FOXK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q01167

UniProtKB/Swiss-Prot:

FOXK2_HUMAN
Domain:
  • The C-terminal part of the DNA-binding domain may contribute to DNA recognition specificity.:
    • Q01167
  • Contains 1 FHA domain.:
    • Q01167
  • Contains 1 fork-head DNA-binding domain.:
    • Q01167
genes like me logo Genes that share domains with FOXK2: view

Function for FOXK2 Gene

Molecular function for FOXK2 Gene

UniProtKB/Swiss-Prot Function: Recognizes the core sequence 5-TAAACA-3. Binds to NFAT-like motifs (purine-rich) in the IL2 promoter. Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements.

Gene Ontology (GO) - Molecular Function for FOXK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 16624804
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 9065434
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 9065434
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 12402362
GO:0005515 protein binding IPI 21903422
genes like me logo Genes that share ontologies with FOXK2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FOXK2 Gene

Localization for FOXK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXK2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXK2 Gene COMPARTMENTS Subcellular localization image for FOXK2 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for FOXK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IC 1909027
GO:0005654 nucleoplasm IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with FOXK2: view

Pathways for FOXK2 Gene

genes like me logo Genes that share pathways with FOXK2: view

Pathways by source for FOXK2 Gene

2 Cell Signaling Technology pathways for FOXK2 Gene

Gene Ontology (GO) - Biological Process for FOXK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 12402362
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 1909027
GO:0009653 anatomical structure morphogenesis IBA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with FOXK2: view

Compounds for FOXK2 Gene

(1) HMDB Compounds for FOXK2 Gene

Compound Synonyms Cas Number PubMed IDs
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with FOXK2: view

Transcripts for FOXK2 Gene

Unigene Clusters for FOXK2 Gene

Forkhead box K2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXK2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - - - - - - - -
SP2: -
SP3:
SP4:
SP5: - - -

Relevant External Links for FOXK2 Gene

GeneLoc Exon Structure for
FOXK2
ECgene alternative splicing isoforms for
FOXK2

Expression for FOXK2 Gene

mRNA expression in normal human tissues for FOXK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FOXK2 Gene

SOURCE GeneReport for Unigene cluster for FOXK2 Gene Hs.591140

mRNA Expression by UniProt/SwissProt for FOXK2 Gene

Q01167-FOXK2_HUMAN
Tissue specificity: Expressed in both lymphoid and non-lymphoid cells.
genes like me logo Genes that share expressions with FOXK2: view

No data available for mRNA differential expression in normal tissues for FOXK2 Gene

Orthologs for FOXK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FOXK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXK2 35
  • 99.54 (n)
  • 99.85 (a)
FOXK2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FOXK2 35
  • 88.56 (n)
  • 93.01 (a)
FOXK2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXK2 35
  • 88.32 (n)
  • 93.42 (a)
FOXK2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxk2 35
  • 86.89 (n)
  • 93.9 (a)
Foxk2 16
Foxk2 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FOXK2 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOXK2 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOXK2 35
  • 79.81 (n)
  • 87.85 (a)
FOXK2 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXK2 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23253 35
tropical clawed frog
(Silurana tropicalis)
Amphibia foxk2 35
  • 77.28 (n)
  • 84.25 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
foxk2 36
  • 76 (a)
OneToMany
FOXK2 (1 of 2) 36
  • 76 (a)
OneToMany
si:ch211-262e15.1 35
  • 74.73 (n)
  • 80.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta fd68A 36
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FKH1 36
  • 15 (a)
ManyToMany
FKH2 36
  • 12 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2618 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9506 36
  • 38 (a)
OneToMany
Species with no ortholog for FOXK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXK2 Gene

ENSEMBL:
Gene Tree for FOXK2 (if available)
TreeFam:
Gene Tree for FOXK2 (if available)

Paralogs for FOXK2 Gene

Selected SIMAP similar genes for FOXK2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FOXK2: view

Variants for FOXK2 Gene

Sequence variations from dbSNP and Humsavar for FOXK2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs4822 -- 82,602,618(+) GGCAC(A/G)TCTGG utr-variant-3-prime
rs8795 -- 82,602,545(+) TGACC(C/T)GCTGT utr-variant-3-prime
rs13382 -- 82,603,877(+) ATATC(A/G)AAGCG utr-variant-3-prime
rs15153 -- 82,604,511(+) TTCTA(A/G)AAAGT utr-variant-3-prime
rs878820 -- 82,568,776(-) CGCCT(C/T)GGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOXK2 Gene

Variant ID Type Subtype PubMed ID
nsv428351 CNV Gain 18775914
dgv3332n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
dgv3354n71 CNV Loss 21882294
nsv909229 CNV Loss 21882294
dgv3360n71 CNV Loss 21882294
nsv833574 CNV Gain 17160897
dgv3361n71 CNV Loss 21882294
nsv909237 CNV Loss 21882294
nsv909238 CNV Loss 21882294
esv1003878 CNV Deletion 20482838
esv2716505 CNV Deletion 23290073
esv2716506 CNV Deletion 23290073
nsv909239 CNV Gain 21882294
nsv509678 CNV Insertion 20534489
nsv2167 CNV Insertion 18451855
nsv166 CNV Insertion 15895083
nsv909240 CNV Loss 21882294
dgv3363n71 CNV Loss 21882294
esv2716508 CNV Deletion 23290073
esv2716509 CNV Deletion 23290073
esv991816 CNV Insertion 20482838
esv2716510 CNV Deletion 23290073
nsv828145 CNV Gain 20364138

Relevant External Links for FOXK2 Gene

HapMap Linkage Disequilibrium report
FOXK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXK2 Gene

Disorders for FOXK2 Gene

(1) University of Copenhagen DISEASES for FOXK2 Gene

genes like me logo Genes that share disorders with FOXK2: view

No data available for UniProtKB/Swiss-Prot for FOXK2 Gene

Publications for FOXK2 Gene

  1. Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein ILF. (PMID: 1339390) Li C. … Gaynor R.B. (Genomics 1992) 3 4 23
  2. Cloning of a cellular factor, interleukin binding factor, that binds to NFAT-like motifs in the human immunodeficiency virus long terminal repeat. (PMID: 1909027) Li C. … Gaynor R.B. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 4 23
  3. Solution structure of the DNA-binding domain of interleukin enhancer binding factor 1 (FOXK1a). (PMID: 12402362) Liu P.-P. … Chuang W.-J. (Proteins 2002) 3 4 23
  4. Crystal structure of the human FOXK1a-DNA complex and its implications on the diverse binding specificity of winged helix/forkhead proteins. (PMID: 16624804) Tsai K.-L. … Hsiao C.-D. (J. Biol. Chem. 2006) 3 4 23
  5. Characterization of antigen receptor response elements within the interleukin-2 enhancer. (PMID: 3260003) Durand D.B. … Crabtree G.R. (Mol. Cell. Biol. 1988) 2 3

Products for FOXK2 Gene

Sources for FOXK2 Gene

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