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FOXK1 Gene

protein-coding   GIFtS: 48
GCID: GC07P004683

Forkhead Box K1

  Search for FOXK1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Forkhead Box K11 2
Myocyte Nuclear Factor2 3
MNF2 3
FOXK1L2
Forkhead Box Protein K12

External Ids:    HGNC: 234801   Entrez Gene: 2219372   Ensembl: ENSG000001649167   UniProtKB: P850373   

Export aliases for FOXK1 gene to outside databases

Previous GC identifers: GC07U901483 GC07P004588 GC07P004496


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FOXK1 Gene:
FOXK1 (forkhead box K1) is a protein-coding gene. GO annotations related to this gene include magnesium ion binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOXF1.

UniProtKB/Swiss-Prot: FOXK1_HUMAN, P85037
Function: Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a
role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to
physiological stimuli (By similarity)

Gene Wiki entry for FOXK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the FOXK1 gene promoter:
         RelA   NF-kappaB   NF-E2 p45   Ik-3   C/EBPalpha   FOXO1a   NF-E2   NF-kappaB1   ATF   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): FOXK1 promoter sequence
   Search Chromatin IP Primers for FOXK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FOXK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.1   Ensembl cytogenetic band:  7p22.1   HGNC cytogenetic band: 7p22

FOXK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXK1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P004683:  view genomic region     (about GC identifiers)

Start:
4,683,388 bp from pter      End:
4,811,074 bp from pter
Size:
127,687 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 4,768,285-4,857,429     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FOXK1_HUMAN, P85037 (See protein sequence)
Recommended Name: Forkhead box protein K1  
Size: 733 amino acids; 75457 Da
Subunit: Interacts with SIN3B to form a complex which represses transcription (By similarity)
Alternative splicing: 2 isoforms:  P85037-1   P85037-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FOXK1: NX_P85037

Explore proteomics data for FOXK1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FOXK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001032242.1  
    ENSEMBL proteins: 
     ENSP00000328720   ENSP00000475486   ENSP00000394442  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FOX: Forkhead boxes

    5 InterPro protein domains:
     IPR008984 SMAD_FHA_domain
     IPR011991 WHTH_DNA-bd_dom
     IPR000253 FHA_dom
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry P85037

    ProtoNet protein and cluster: P85037

    UniProtKB/Swiss-Prot: FOXK1_HUMAN, P85037
    Similarity: Contains 1 FHA domain
    Similarity: Contains 1 fork-head DNA-binding domain


    Find genes that share domains with FOXK1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOXK1_HUMAN, P85037
    Function: Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a
    role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to
    physiological stimuli (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IBA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI--
    GO:0008301DNA binding, bending IBA--
         
    Find genes that share ontologies with FOXK1           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Foxk1):
     behavior/neurological  cellular  growth/size/body  mortality/aging  muscle 

    Find genes that share phenotypes with FOXK1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Foxk1tm1Djg for FOXK1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FOXK1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FOXK1_HUMAN, P85037: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with FOXK1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FOXK1
    Interactions:

        Search GeneGlobe Interaction Network for FOXK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FOXK1 (P850371, 3 ENSP000003287204) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IRF2P143161, 3, ENSP000003772184EBI-2509974,EBI-2866589 I2D: score=1 STRING: ENSP00000377218
    BAP1Q925603, ENSP000004171324I2D: score=3 STRING: ENSP00000417132
    FYCO1Q9BQS83, ENSP000002961374I2D: score=3 STRING: ENSP00000296137
    MAP1LC3AQ9H4923, ENSP000003639704I2D: score=1 STRING: ENSP00000363970
    AMOTQ4VCS53, ENSP000003610274I2D: score=2 STRING: ENSP00000361027
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    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IEA--
    GO:0007389pattern specification process IBA--
    GO:0007517muscle organ development IEA--

    Find genes that share ontologies with FOXK1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FOXK1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FOXK1 gene: 
    NM_001037165.1  

    Unigene Cluster for FOXK1:

    Forkhead box K1
    Hs.487393  [show with all ESTs]
    Unigene Representative Sequence: NM_001037165
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328914(uc003sna.1 uc003snb.1 uc003snc.1) ENST00000460979
    ENST00000496023 ENST00000446823
    miRNA
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    Block miRNA regulation of human, mouse, rat FOXK1 using miScript Target Protectors
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    hsa-miR-3607-3p hsa-miR-15a hsa-miR-485-3p hsa-miR-632 hsa-miR-371-5p hsa-miR-3150b-3p hsa-miR-200b hsa-miR-4324
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      QuantiFast Probe-based Assays in human, mouse, rat FOXK1

    Additional mRNA sequence: 

    AK022628.1 AK122663.1 AK302243.1 BC038434.1 BX538089.1 

    11 DOTS entries:

    DT.91666561  DT.443423  DT.309308  DT.95262466  DT.121048047  DT.95190633  DT.91808076  DT.100737927 
    DT.121048088  DT.87015898  DT.97825583 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FOXK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FOXK1 Expression
    About this image


    FOXK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Muscle Satellite Cells Lumbar Muscle Satellite Pool
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    FOXK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FOXK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.487393

    UniProtKB/Swiss-Prot: FOXK1_HUMAN, P85037
    Tissue specificity: Expressed both developing and adult tissues. In adults, significant expression is seen in
    tumors of the brain, colon and lymph node

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FOXK1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Foxk11 , 5 forkhead box K11, 5 85.77(n)1
    92.28(a)1
      5 (81.53 cM)5
    174251  NM_199068.21  NP_951031.21 
     1424014975 
    chicken
    (Gallus gallus)
    Aves FOXK11 forkhead box K1 76.24(n)
    86.5(a)
      395463  XM_414784.3  XP_414784.3 
    lizard
    (Anolis carolinensis)
    Reptilia FOXK16
    forkhead box K1
    82(a)
    1 ↔ 1
    GL343591.1(112646-149235)
    zebrafish
    (Danio rerio)
    Actinopterygii wufi75f052 wufi75f05 77.42(n)   334470  BC054664.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fd68A6
    forkhead domain 68A
    29(a)
    1 → many
    3L(11107269-11113875)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FHL1(YPR104C)4 Regulator of ribosomal protein transcription; has forkhead more   --   16(736433-733623) 856219  NP_015429.1 


    ENSEMBL Gene Tree for FOXK1 (if available)
    TreeFam Gene Tree for FOXK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FOXK1 gene
    FOXF12  FOXQ12  FOXN32  FOXJ12  FOXF22  FOXN42  FOXR12  FOXH12  
    FOXK22  FOXN12  FOXJ32  FOXG12  FOXJ22  FOXN22  FOXR22  
    2 SIMAP similar genes for FOXK1 using alignment to 2 protein entries:     FOXK1_HUMAN (see all proteins):
    FOXK2    KIAA0415

    Find genes that share paralogs with FOXK1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FOXK1 (see all 2566)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1847132411,2
    C--4719966(+) GAATCA/GGTTGC 1 -- us2k10--------
    rs1880564701,2
    --4720247(+) AGGGAA/GAGAAA 1 -- us2k10--------
    rs1922406671,2
    --4720250(+) GAAAGA/GAAGGA 1 -- us2k10--------
    rs1500116531,2
    --4720254(+) GAAAGA/GAAGGA 1 -- us2k10--------
    rs1857442151,2
    C--4720258(+) GGAAGA/GAAGGA 1 -- us2k10--------
    rs1449749641,2
    --4720303(+) GAAGGA/CAGGCA 1 -- us2k10--------
    rs69684451,2
    C,F--4720307(+) gaaggC/Aaggca 1 -- us2k12Minor allele frequency- A:0.50NA 4
    rs624531941,2
    C--4720311(+) GCAGGA/CAGGCG 1 -- us2k10--------
    rs1467507581,2
    C--4720392(+) CGGGTG/TTTCAG 1 -- us2k10--------
    rs1404303511,2
    C--4720442(+) AAAAAA/GTACAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FOXK1 (4683388 - 4811074 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FOXK1 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664593CNV Deletion23128226
    esv2157596CNV Deletion18987734
    esv2380266CNV Deletion18987734
    esv2678462CNV Deletion23128226
    nsv887379CNV Loss21882294
    nsv508442CNV Loss20534489
    nsv887377CNV Loss21882294
    dgv7134n71CNV Loss21882294
    nsv471293CNV Loss18288195
    dgv7135n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FOXK1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease from the University of Copenhagen DISEASES database for FOXK1:
    Epidermodysplasia verruciformis

    Find genes that share disorders with FOXK1           About GenesLikeMe


    Export disorders for FOXK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FOXK1 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with FOXK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human FOXK1 gene in silico. (PubMed id 15202027)1, 2, 3 Katoh M. and Katoh M. (Int. J. Mol. Med. 2004)
    2. Identification and characterization of a novel human FOXK1 gene in silico. (PubMed id 15289879)1, 2, 9 Huang J.T. and Lee V. (Int. J. Oncol. 2004)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    7. Gene network analysis in a pediatric cohort identifies novel lung function genes. (PubMed id 24023788)1 Ong B.A....Hakonarson H. (PLoS ONE 2013)
    8. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    9. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 221937 HGNC: 23480 Ensembl:ENSG00000164916 euGenes: HUgn221937 ECgene: FOXK1
    H-InvDB: FOXK1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FOXK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FOXK1 gene:
    Search GeneIP for patents involving FOXK1

    GeneCards and IP:
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