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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FOXK1 Gene

protein-coding   GIFtS: 47
GCID: GC07P004683

forkhead box K1
 Explore 1 disease affiliated with
FOXK1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FOXK1    

Aliases
for FOXK1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Forkhead Box K11 2
Myocyte Nuclear Factor2 3
MNF2 3
IMAGE:51644971
FOXK1L2
Forkhead Box Protein K12

External Ids:    HGNC: 234801   Entrez Gene: 2219372   Ensembl: ENSG000001649167   UniProtKB: P850373   

Export aliases for FOXK1 gene to outside databases

Previous GC identifers: GC07U901483 GC07P004588 GC07P004496


Summaries
for FOXK1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: FOXK1_HUMAN, P85037
Function: Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role
in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological
stimuli (By similarity)

Gene Wiki entry for FOXK1


Genomic Views
for FOXK1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FOXK1 gene promoter:
         RelA   NF-kappaB   NF-E2 p45   Ik-3   C/EBPalpha   FOXO1a   NF-E2   NF-kappaB1   ATF   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): FOXK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FOXK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.1   Ensembl cytogenetic band:  7p22.1   HGNC cytogenetic band: 7p22

FOXK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXK1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P004683:  view genomic region     (about GC identifiers)

Start:
 4,683,388 bp from pter      End:
 4,811,074 bp from pter
Size:
 127,687 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 4,768,285-4,857,429     

Proteins
for FOXK1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FOXK1_HUMAN, P85037 (See protein sequence)
Recommended Name: Forkhead box protein K1  
Size: 733 amino acids; 75457 Da
Subunit: Interacts with SIN3B to form a complex which represses transcription (By similarity)
Subcellular location: Nucleus (Probable)
Alternative splicing: 2 isoforms:  P85037-1   P85037-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FOXK1: NX_P85037

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P85037

    • FOXK1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001032242.1  
    ENSEMBL proteins: 
     ENSP00000328720   ENSP00000394442  

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    Uscn Proteins for FOXK1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005667transcription factor complex IBA--
    GO:0005730NOT nucleolus IDA--


    FOXK1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for FOXK1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FOXK1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR008984 SMAD_FHA_domain
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR000253 FHA_dom
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry P85037

    ProtoNet protein and cluster: P85037

    UniProtKB/Swiss-Prot: FOXK1_HUMAN, P85037
    Similarity: Contains 1 FHA domain
    Similarity: Contains 1 fork-head DNA-binding domain


    Function
    for FOXK1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FOXK1_HUMAN, P85037
    Function: Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role
    in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological
    stimuli (By similarity)

    miRNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IBA--
    GO:0003677DNA binding ----
    GO:0003690double-stranded DNA binding IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IBA--


    FOXK1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Foxk1tm1Djg for FOXK1
         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Foxk1):
     behavior/neurological  cellular  growth/size  mortality/aging  muscle 

    FOXK1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FOXK1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOXK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/11 Interacting proteins for FOXK1 (P850371, 3 ENSP000003287204) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IRF2P143161, 3, ENSP000003772184EBI-2509974,EBI-3918980 I2D: score=1 STRING: ENSP00000377218
    BAP1Q925603, ENSP000004171324I2D: score=3 STRING: ENSP00000417132
    FYCO1Q9BQS83, ENSP000002961374I2D: score=3 STRING: ENSP00000296137
    MAP1LC3AQ9H4923, ENSP000003639704I2D: score=1 STRING: ENSP00000363970
    AMOTQ4VCS53, ENSP000003610274I2D: score=2 STRING: ENSP00000361027
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0007389pattern specification process IBA--
    GO:0007517muscle organ development IEA--
    GO:0009790embryo development IBA--
    GO:0009888tissue development IBA--


    FOXK1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FOXK1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FOXK1
    Search CenterWatch for drugs/clinical trials and news about FOXK1 

    Transcripts
    for FOXK1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FOXK1 gene: 
    NM_001037165.1  

    Unigene Cluster for FOXK1:

    Forkhead box K1
    Hs.487393  [show with all ESTs]
    Unigene Representative Sequence: NM_001037165
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328914(uc003sna.1 uc003snb.1 uc003snc.1) ENST00000460979
    ENST00000496023 ENST00000446823

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    hsa-miR-3607-3p hsa-miR-15a hsa-miR-485-3p hsa-miR-632 hsa-miR-371-5p hsa-miR-3150b-3p hsa-miR-200b hsa-miR-4324
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    Inhib. RNA
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    OriGene shRNA RFP: FOXK1
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXK1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXK1

    Additional cDNA sequence: 

    AK022628.1 AK122663.1 AK302243.1 BC038434.1 BX538089.1 

    11 DOTS entries:

    DT.91666561  DT.443423  DT.309308  DT.95262466  DT.121048047  DT.95190633  DT.91808076  DT.100737927 
    DT.121048088  DT.87015898  DT.97825583 

    GeneLoc Exon Structure


    Expression
    for FOXK1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FOXK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FOXK1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbForelimb Muscle Satellite PoolForelimb Muscle Satellite CellsSkeletal Muscle
    LimbHindlimb Muscle Satellite PoolHindlimb Muscle Satellite CellsSkeletal Muscle
    Skeletal MuscleCervical Muscle Satellite PoolMuscle Satellite CellsSkeletal Muscle
    Skeletal MuscleLumbar Muscle Satellite PoolMuscle Satellite CellsSkeletal Muscle
    Skeletal MuscleSacral Muscle Satellite PoolMuscle Satellite CellsSkeletal Muscle
    Skeletal MuscleThoracic Muscle Satellite PoolMuscle Satellite CellsSkeletal Muscle
    Skeletal MuscleHyoid Arch MusclesMyoblastsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMyoblastsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FOXK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FOXK1

    SOURCE GeneReport for Unigene cluster: Hs.487393

    UniProtKB/Swiss-Prot: FOXK1_HUMAN, P85037
    Tissue specificity: Expressed both developing and adult tissues. In adults, significant expression is seen in tumors of
    the brain, colon and lymph node

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    In Situ
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    Orthologs
    for FOXK1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FOXK1 gene from 4/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FOXK11 forkhead box K1 76.72(n)
    86.91(a)    		   395463  XM_414784.2  XP_414784.2 
    lizard
    (Anolis carolinensis)    		 Reptilia FOXK16
    		 --
    		 82(a)
    		 1 ↔ 1
    		 GL343591.1(134570-149235)
    zebrafish
    (Danio rerio)    		 Actinopterygii wufi75f052 wufi75f05 77.42(n)   334470  BC054664.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta fd68A6
    		 forkhead domain 68A
    		 19(a)
    		 1 → many
    		 3L(11107269-11113875)


    ENSEMBL Gene Tree for FOXK1 (if available)
    TreeFam Gene Tree for FOXK1 (if available) 

    Paralogs
    for FOXK1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FOXK1 gene
    FOXJ12  FOXN32  FOXN42  FOXN12  FOXK22  FOXP42  FOXG12  FOXJ32  
    FOXJ22  FOXP22  FOXN22  FOXP32  FOXP12  
    2 SIMAP similar genes for FOXK1 using alignment to 1 protein entry:     FOXK1_HUMAN:
    FOXK2    KIAA0415

    FOXK1 for paralogs           About GeneDecksing



    Genomic Variants
    for FOXK1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2073 NCBI SNPs in FOXK1 are shown (see all 2073)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1847132411,2
    		--4719966(+) GAATCA/GGTTGC 1 -- us2k10--------
    rs1880564701,2
    		--4720247(+) AGGGAA/GAGAAA 1 -- us2k10--------
    rs1922406671,2
    		--4720250(+) GAAAGA/GAAGGA 1 -- us2k10--------
    rs1500116531,2
    		--4720254(+) GAAAGA/GAAGGA 1 -- us2k10--------
    rs1857442151,2
    		--4720258(+) GGAAGA/GAAGGA 1 -- us2k10--------
    rs1449749641,2
    		--4720303(+) GAAGGA/CAGGCA 1 -- us2k10--------
    rs69684451,2
    		C,F,--4720307(+) GAAGGC/AAGGCA 1 -- us2k12Minor allele frequency- A:0.50NA 4
    rs624531941,2
    		--4720311(+) GCAGGA/CAGGCG 1 -- us2k10--------
    rs1467507581,2
    		--4720392(+) CGGGTG/TTTCAG 1 -- us2k10--------
    rs1404303511,2
    		--4720442(+) AAAAAA/GTACAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FOXK1 (4683388 - 4811074 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for FOXK1
         1 CNV: 3662
         2 Indels: 12904 47362

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for FOXK1

    Disorders / Diseases
    for FOXK1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FOXK1 for disorders           About GeneDecksing

    1 disease for FOXK1:    About MalaCards
    epidermodysplasia verruciformis

    1 disease from the University of Copenhagen DISEASES database for FOXK1:
    Epidermodysplasia verruciformis

    Export disorders for FOXK1 gene to outside databases

    Publications
    for FOXK1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FOXK1 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with FOXK1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human FOXK1 gene in silico. (PubMed id 15202027)1, 2, 3 Katoh M. and Katoh M. (2004)
    2. Identification and characterization of a novel human FOXK1 gene in silico. (PubMed id 15289879)1, 2, 9 Huang J.T. and Lee V. (2004)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    7. Live-cell monitoring of periodic gene expression in sy nchronous human cells identifies Forkhead genes involved in cell cycle control. (PubMed id 22740631)1 Grant G.D....Whitfield M.L. (2012)
    8. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    9. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for FOXK1 gene

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    Genome Databases showing FOXK1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 221937 HGNC: 23480 Ensembl:ENSG00000164916 euGenes: HUgn221937 ECgene: FOXK1
    H-InvDB: FOXK1

    Other Databases showing FOXK1 gene

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    Specialized Databases showing FOXK1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    NameDescription
    PharmGKB entry for FOXK1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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