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Aliases for FOXK1 Gene

Aliases for FOXK1 Gene

  • Forkhead Box K1 2 3 5
  • Myocyte Nuclear Factor 3 4
  • MNF 3 4
  • Forkhead Box Protein K1 3
  • FOXK1L 3

External Ids for FOXK1 Gene

Previous GeneCards Identifiers for FOXK1 Gene

  • GC07U901483
  • GC07P004588
  • GC07P004496

Summaries for FOXK1 Gene

GeneCards Summary for FOXK1 Gene

FOXK1 (Forkhead Box K1) is a Protein Coding gene. Diseases associated with FOXK1 include Contagious Pustular Dermatitis and Thyroid Angiosarcoma. Among its related pathways are Metabolism of proteins and Deubiquitination. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXK2.

UniProtKB/Swiss-Prot for FOXK1 Gene

  • Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Important regulatory factor of the myogenic progenitor cell population. Involved in the cell cycle process, promotes proliferation by repressing Foxo4 transcriptional activity and the cyclin-dependent kinase inhibitor, p21CIP, in the myogenic progenitor cells. Represses myogenic differentiation by inhibiting MEFC acitivity. Has a role in remodeling processes of adult muscles that occur in response to physiological stimuli. Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136).

Gene Wiki entry for FOXK1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXK1 Gene

Genomics for FOXK1 Gene

Regulatory Elements for FOXK1 Gene

Enhancers for FOXK1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F004765 0.2 ENCODE 31.5 +123.3 123281 4.4 ZNF263 CTCF TFAP4 MAZ PKNOX1 KLF17 FEZF1 NFXL1 POLR2A PBX2 FOXK1 AP5Z1 RBAKDN RADIL GC07P004766 PIR39599 PIR61632
GH07F004681 0.9 ENCODE 11.2 +38.9 38882 4.4 HDGF CREB3L1 WRNIP1 ARID4B SIN3A YBX1 YY1 ZNF416 ZNF143 ZNF207 RPL22P16 AP5Z1 ENSG00000188365 FOXK1 RNF216P1 TNRC18 SNORD13P2
GH07F004741 1 Ensembl ENCODE 5.4 +101.2 101203 8.5 HDGF MLX ARID4B SIN3A FEZF1 YY1 FOS KLF13 SP3 SP5 AP5Z1 ZNF890P RBAKDN FOXK1 RADIL PIR62911 PIR42800
GH07F003997 0.6 ENCODE 5.4 -646.6 -646608 1.2 MAFK FOXK1 SDK1 GC07P003989 LOC105375131
GH07F004006 0.9 Ensembl ENCODE 4.8 -637.9 -637931 1.5 PKNOX1 ARID4B DMAP1 ZNF48 RAD21 RARA CREM MIXL1 HMG20B SP5 FOXK1 GC07P003989 LOC105375131
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FOXK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FOXK1 Gene

Chromosome:
7
Start:
4,644,691 bp from pter
End:
4,771,443 bp from pter
Size:
126,753 bases
Orientation:
Plus strand

Genomic View for FOXK1 Gene

Genes around FOXK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXK1 Gene

Proteins for FOXK1 Gene

  • Protein details for FOXK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P85037-FOXK1_HUMAN
    Recommended name:
    Forkhead box protein K1
    Protein Accession:
    P85037

    Protein attributes for FOXK1 Gene

    Size:
    733 amino acids
    Molecular mass:
    75457 Da
    Quaternary structure:
    • Interacts with SIN3A and SIN3B (via PAH2) to form a complex which represses transcription (By similarity). Interacts with FOXO4 and MEF2C; both interactions inhibit FOXO4 and MEF2C transactivation activity (By similarity). Interacts with DVL2 and DVL3; the interaction induces DVL2 nuclear translocation (PubMed:25805136).

    Alternative splice isoforms for FOXK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXK1 Gene

Post-translational modifications for FOXK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FOXK1 (FOXK1)
  • Abcam antibodies for FOXK1

No data available for DME Specific Peptides for FOXK1 Gene

Domains & Families for FOXK1 Gene

Gene Families for FOXK1 Gene

Suggested Antigen Peptide Sequences for FOXK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P85037

UniProtKB/Swiss-Prot:

FOXK1_HUMAN :
  • Contains 1 FHA domain.
Domain:
  • Contains 1 FHA domain.
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXK1: view

Function for FOXK1 Gene

Molecular function for FOXK1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Important regulatory factor of the myogenic progenitor cell population. Involved in the cell cycle process, promotes proliferation by repressing Foxo4 transcriptional activity and the cyclin-dependent kinase inhibitor, p21CIP, in the myogenic progenitor cells. Represses myogenic differentiation by inhibiting MEFC acitivity. Has a role in remodeling processes of adult muscles that occur in response to physiological stimuli. Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136).

Gene Ontology (GO) - Molecular Function for FOXK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA,IBA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 21903422
genes like me logo Genes that share ontologies with FOXK1: view
genes like me logo Genes that share phenotypes with FOXK1: view

Animal Models for FOXK1 Gene

MGI Knock Outs for FOXK1:

Animal Model Products

miRNA for FOXK1 Gene

miRTarBase miRNAs that target FOXK1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOXK1 Gene

Localization for FOXK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXK1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXK1 Gene COMPARTMENTS Subcellular localization image for FOXK1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for FOXK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with FOXK1: view

Pathways & Interactions for FOXK1 Gene

genes like me logo Genes that share pathways with FOXK1: view

Pathways by source for FOXK1 Gene

Gene Ontology (GO) - Biological Process for FOXK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0007275 multicellular organism development IEA --
GO:0007517 muscle organ development IEA --
genes like me logo Genes that share ontologies with FOXK1: view

No data available for SIGNOR curated interactions for FOXK1 Gene

Transcripts for FOXK1 Gene

mRNA/cDNA for FOXK1 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXK1 Gene

Forkhead box K1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXK1 Gene

No ASD Table

Relevant External Links for FOXK1 Gene

GeneLoc Exon Structure for
FOXK1
ECgene alternative splicing isoforms for
FOXK1

Expression for FOXK1 Gene

mRNA expression in normal human tissues for FOXK1 Gene

Protein differential expression in normal tissues from HIPED for FOXK1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FOXK1 Gene



Protein tissue co-expression partners for FOXK1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FOXK1 Gene:

FOXK1

SOURCE GeneReport for Unigene cluster for FOXK1 Gene:

Hs.487393

mRNA Expression by UniProt/SwissProt for FOXK1 Gene:

P85037-FOXK1_HUMAN
Tissue specificity: Expressed both developing and adult tissues. In adults, significant expression is seen in tumors of the brain, colon and lymph node.
genes like me logo Genes that share expression patterns with FOXK1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FOXK1 Gene

Orthologs for FOXK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FOXK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXK1 34 35
  • 99.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FOXK1 35
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXK1 34 35
  • 88.11 (n)
cow
(Bos Taurus)
Mammalia FOXK1 34 35
  • 87.45 (n)
mouse
(Mus musculus)
Mammalia Foxk1 34 16 35
  • 85.77 (n)
rat
(Rattus norvegicus)
Mammalia Foxk1 34
  • 85.62 (n)
oppossum
(Monodelphis domestica)
Mammalia FOXK1 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOXK1 34 35
  • 76.24 (n)
lizard
(Anolis carolinensis)
Reptilia FOXK1 35
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii foxk1 34 35
  • 71.29 (n)
wufi75f05 34
fruit fly
(Drosophila melanogaster)
Insecta fd68A 35
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FKH1 35
  • 14 (a)
ManyToMany
FKH2 35
  • 11 (a)
ManyToMany
FHL1 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9506 35
  • 37 (a)
OneToMany
Species where no ortholog for FOXK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXK1 Gene

ENSEMBL:
Gene Tree for FOXK1 (if available)
TreeFam:
Gene Tree for FOXK1 (if available)

Paralogs for FOXK1 Gene

(2) SIMAP similar genes for FOXK1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FOXK1: view

Variants for FOXK1 Gene

Sequence variations from dbSNP and Humsavar for FOXK1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1001396 -- 4,679,000(+) TTCTG(C/T)ATCAC intron-variant
rs10215880 -- 4,768,936(+) CGGGA(G/T)GCCTG utr-variant-3-prime
rs10227837 -- 4,688,465(+) gcact(A/G)tcttg intron-variant
rs10228886 -- 4,743,593(+) ATTGC(A/G)TCTGA intron-variant
rs10229288 -- 4,740,169(+) ctcac(G/T)cctgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOXK1 Gene

Variant ID Type Subtype PubMed ID
esv2157596 CNV deletion 18987734
esv2380266 CNV deletion 18987734
esv2664593 CNV deletion 23128226
esv2678462 CNV deletion 23128226
esv2759503 CNV gain 17122850
esv3541087 CNV deletion 23714750
esv3571581 CNV loss 25503493
esv3611947 CNV loss 21293372
esv3611948 CNV loss 21293372
nsv1019692 CNV loss 25217958
nsv1074064 CNV deletion 25765185
nsv1124164 CNV deletion 24896259
nsv1133647 CNV deletion 24896259
nsv1145124 CNV deletion 24896259
nsv366495 CNV deletion 16902084
nsv471293 CNV loss 18288195
nsv508442 CNV deletion 20534489
nsv8033 CNV loss 18304495
nsv823994 CNV gain 20364138
nsv950797 CNV deletion 24416366

Variation tolerance for FOXK1 Gene

Residual Variation Intolerance Score: 6.33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.80; 73.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXK1 Gene

Human Gene Mutation Database (HGMD)
FOXK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXK1 Gene

Disorders for FOXK1 Gene

MalaCards: The human disease database

(13) MalaCards diseases for FOXK1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
contagious pustular dermatitis
  • ecthyma contagiosum
thyroid angiosarcoma
  • hemangiosarcoma of the thyroid
thyroid sarcoma
  • sarcoma of the thyroid gland
pericardium cancer
  • malignant neoplasm of pericardium
benign breast phyllodes tumor
  • benign cystosarcoma phyllodes
- elite association - COSMIC cancer census association via MalaCards
Search FOXK1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FOXK1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXK1
genes like me logo Genes that share disorders with FOXK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOXK1 Gene

Publications for FOXK1 Gene

  1. Identification and characterization of human FOXK1 gene in silico. (PMID: 15202027) Katoh M. … Katoh M. (Int. J. Mol. Med. 2004) 2 3 4 64
  2. Identification and characterization of a novel human FOXK1 gene in silico. (PMID: 15289879) Huang J.T. … Lee V. (Int. J. Oncol. 2004) 3 4 22 64
  3. FOXKs promote Wnt/I^-catenin signaling by translocating DVL into the nucleus. (PMID: 25805136) Wang W. … Chen J. (Dev. Cell 2015) 3 4 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for FOXK1 Gene

Sources for FOXK1 Gene

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