FOXJ3 Gene
protein-coding GIFtS: 49
GCID: GC01M042642
|
|
forkhead box J3
| |
Aliases
for FOXJ3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Forkhead Box J31 2 | | KIAA10411 3 | | Forkhead Box Protein J32 |
Export aliases for FOXJ3 gene to outside databasesPrevious GC identifers: GC01M042056 GC01M042311 GC01M042414 GC01M040761 |
Summaries
for FOXJ3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FOXJ3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FOXJ3 gene promoter:
COUP-TF1 COUP-TF FOXO4 COUP FOXO1a HNF-4alpha1 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FOXJ3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXJ3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p34.2 Ensembl cytogenetic band: 1p34.2 HGNC cytogenetic band: 1p34.2FOXJ3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M042642: view genomic region
(about GC identifiers)
Start:
|
42,642,210 bp from pter |
End:
|
42,801,548 bp from pter |
Size:
|
159,339 bases |
Orientation:
|
minus strand |
|
Proteins
for FOXJ3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FOXJ3_HUMAN, Q9UPW0 (See
protein sequence)Recommended Name: Forkhead box protein J3 Size: 622 amino acids; 68960 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAA82993.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A7MBL7 A7MD18 D3DPW2 Q9NSS7Alternative splicing: 2 isoforms: Q9UPW0-1 Q9UPW0-2 Explore the universe of human proteins at neXtProt for FOXJ3: NX_Q9UPW0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UPW0
FOXJ3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001185779.1 NP_001185780.1 NP_001185781.1 NP_055762.3
ENSEMBL proteins: ENSP00000361654 ENSP00000361653 ENSP00000361652 ENSP00000393408 ENSP00000388099 ENSP00000403060 ENSP00000354620 ENSP00000354449 ENSP00000439044
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
-- | -- | | GO:0005667 | transcription factor complex |
IBA | -- |
FOXJ3 for ontologies About GeneDecksing
FOXJ3 Antibody Products:
Assay Products for FOXJ3: |
Protein
Domains /
Families
for FOXJ3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FOXJ3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UPW0ProtoNet protein and cluster: Q9UPW0 UniProtKB/Swiss-Prot: FOXJ3_HUMAN, Q9UPW0Similarity: Contains 1 fork-head DNA-binding domain |
Function
for FOXJ3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXJ3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXJ3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): FOXJ3 (NM_014947) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOXJ3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXJ3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXJ3 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003690 | double-stranded DNA binding |
IBA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
-- | -- | | GO:0003705 | RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity |
IBA | -- | | GO:0008134 | transcription factor binding |
IBA | -- | | GO:0008301 | DNA binding, bending |
IBA | -- |
FOXJ3 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for FOXJ3:
Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Foxj3):
FOXJ3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for FOXJ3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOXJ3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/8 Interacting proteins for FOXJ3 (Q9UPW03 ENSP000003546204) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
-- | -- | | GO:0007389 | pattern specification process |
IBA | -- | | GO:0009790 | embryo development |
IBA | -- | | GO:0009888 | tissue development |
IBA | -- | | GO:0045893 | positive regulation of transcription, DNA-dependent |
IBA | -- |
FOXJ3 for ontologies About GeneDecksing
|
Drugs & Compounds
for FOXJ3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FOXJ3
Search CenterWatch for drugs/clinical trials and news about FOXJ3
|
Transcripts
for FOXJ3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FOXJ3 gene (4 alternative transcripts): NM_001198850.1 NM_001198851.1 NM_001198852.1 NM_014947.4 Unigene Cluster for FOXJ3: Forkhead box J3 Hs.26023 [show with all ESTs]Unigene Representative Sequence: BC1524419 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372573(uc001chg.3) ENST00000372572(uc001che.3) ENST00000372571
ENST00000445886 ENST00000422278 ENST00000454417 ENST00000361346(uc001chf.3)
ENST00000361776(uc001chh.2) ENST00000545068
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXJ3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXJ3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): FOXJ3 (NM_014947) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOXJ3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXJ3 |
Additional cDNA sequence: AB028964.1 AK027075.1 BC014182.2 BC063298.1 BC151828.1 BC152441.1 17 DOTS entries: DT.316177 DT.99950044 DT.91803316 DT.101973733 DT.100750141 DT.75182088 DT.456174 DT.121458429 DT.40300287 DT.100777956 DT.95249819 DT.102842735 DT.92436584 DT.92436585 DT.97809375 DT.40258934 DT.95070551 24/233 AceView cDNA sequences (see all 233): CF541154 AA626006 BM471382 BU734067 CB240719 CK820129 AA370195 AW672860 BU616496 CD366264 CK820128 AA262135 BM142372 N23802 BQ183747 CA428440 NM_014947 AW675450 AW600272 BC063298 BU621907 AI492204 AA902556 AL556276
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for FOXJ3 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b |
|---|
|
| SP1: | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FOXJ3
|
Expression
for FOXJ3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FOXJ3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGGCACTT
About this image
See FOXJ3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FOXJ3
SOURCE GeneReport for Unigene cluster: Hs.26023
SABiosciences Custom PCR Arrays for FOXJ3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOXJ3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FOXJ3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXJ3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXJ3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXJ3 |
Orthologs
for FOXJ3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FOXJ3 gene from 1/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
CD590856.12 |
-- |
76.24(n) |
|
CD590856.1 |
ENSEMBL Gene Tree for FOXJ3 (if available)
TreeFam Gene Tree for FOXJ3 (if available) |
Paralogs
for FOXJ3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FOXJ3 gene
- FOXJ12 FOXN32 FOXK12 FOXN42 FOXN12 FOXK22 FOXP42 FOXG12
- FOXJ22 FOXP22 FOXN22 FOXP32 FOXP12
9 SIMAP similar genes for FOXJ3 using alignment to 5 protein entries: FOXJ3_HUMAN (see all proteins):FOXC2 FOXI1 FOXK2 FOXD1 FOXN3 FOXC1
FOXL2 FOXP1 FOXJ2
FOXJ3 for paralogs About GeneDecksing
|
Genomic Variants
for FOXJ3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FOXJ3 (42642210 - 42801548 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for FOXJ3
4 CNVs: 68477 63602 97342 84197 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOXJ3 |
|
Disorders
/ Diseases
for FOXJ3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 FOXJ3 for disorders About MalaCards
FOXJ3 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: FOXJ3 (1 document)
Export disorders for FOXJ3 gene to outside databases
|
Publications
for FOXJ3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FOXJ3 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with FOXJ3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R....Ohara O. (1999)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Live-cell monitoring of periodic gene expression in sy nchronous human cells identifies Forkhead genes involved in cell cycle control. (PubMed id 22740631)1 Grant G.D....Whitfield M.L. (2012)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- The protein network surrounding the human telomere re peat binding factors TRF1, TRF2, and POT1. (PubMed id 20811636)1 Giannone R.J....Liu Y. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
|
External Searches for FOXJ3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FOXJ3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FOXJ3 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing FOXJ3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FOXJ3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FOXJ3 gene:
Search GeneIP for patents involving FOXJ3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FOXJ3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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