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Aliases for FOXJ3 Gene

Aliases for FOXJ3 Gene

  • Forkhead Box J3 2 3 5
  • KIAA1041 4

External Ids for FOXJ3 Gene

Previous GeneCards Identifiers for FOXJ3 Gene

  • GC01M042056
  • GC01M042311
  • GC01M042414
  • GC01M042642
  • GC01M040761

Summaries for FOXJ3 Gene

GeneCards Summary for FOXJ3 Gene

FOXJ3 (Forkhead Box J3) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXJ2.

UniProtKB/Swiss-Prot for FOXJ3 Gene

  • Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration.

Additional gene information for FOXJ3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXJ3 Gene

Genomics for FOXJ3 Gene

Regulatory Elements for FOXJ3 Gene

Enhancers for FOXJ3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H042923 1.6 Ensembl ENCODE dbSUPER 41.5 -588.9 -588876 3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 FOXJ3 SZT2 HYI MKRN8P HNRNPFP1 PPIH P3H1 RNU6-880P CCDC30 ENSG00000228192
GH01H041492 2 FANTOM5 Ensembl ENCODE dbSUPER 28.3 +837.2 837156 12 ARNT ZNF2 ZNF143 ZNF548 FOS SP3 REST SMARCB1 ZNF592 SMARCA4 EXO5 FOXJ3 EDN2 ENSG00000230881 LOC100418723 SCMH1 RIMS3 LOC101929901 GC01M041492 GC01M041516
GH01H041514 1.8 FANTOM5 Ensembl ENCODE dbSUPER 23.7 +819.9 819932 3 HDGF PKNOX1 BRCA1 ZNF2 GLIS2 ELK1 ZNF143 ATF7 MIER2 REST FOXJ3 SLFNL1 GC01M041516 GC01M041531
GH01H042177 1.2 Ensembl ENCODE 29.5 +158.3 158263 0 FEZF1 ZNF2 FOS YY2 TSHZ1 ZNF488 ZNF662 ZNF518A GLIS1 MYNN FOXJ3 P3H1 ZNF691 HNRNPFP1 MKRN8P ENSG00000213987 PPIH GC01P042164 GC01M042279 PIR49391
GH01H042333 1.2 ENCODE 28.2 +0.4 412 4 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ZFP41 CCDC30 P3H1 FOXJ3 PPIH HNRNPFP1 MKRN8P CLDN19 GUCA2B RNU6-536P ENSG00000236180
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FOXJ3 on UCSC Golden Path with GeneCards custom track

Promoters for FOXJ3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000005475 977 2601 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ZFP41

Genomic Location for FOXJ3 Gene

Chromosome:
1
Start:
42,176,539 bp from pter
End:
42,335,877 bp from pter
Size:
159,339 bases
Orientation:
Minus strand

Genomic View for FOXJ3 Gene

Genes around FOXJ3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXJ3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXJ3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXJ3 Gene

Proteins for FOXJ3 Gene

  • Protein details for FOXJ3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPW0-FOXJ3_HUMAN
    Recommended name:
    Forkhead box protein J3
    Protein Accession:
    Q9UPW0
    Secondary Accessions:
    • A7MBL7
    • A7MD18
    • D3DPW2
    • Q9NSS7

    Protein attributes for FOXJ3 Gene

    Size:
    622 amino acids
    Molecular mass:
    68960 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA82993.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FOXJ3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXJ3 Gene

Post-translational modifications for FOXJ3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FOXJ3 Gene

Domains & Families for FOXJ3 Gene

Gene Families for FOXJ3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FOXJ3 Gene

Suggested Antigen Peptide Sequences for FOXJ3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FOXJ3: view

No data available for UniProtKB/Swiss-Prot for FOXJ3 Gene

Function for FOXJ3 Gene

Molecular function for FOXJ3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration.

Gene Ontology (GO) - Molecular Function for FOXJ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IC --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0043565 sequence-specific DNA binding IDA 23332764
genes like me logo Genes that share ontologies with FOXJ3: view
genes like me logo Genes that share phenotypes with FOXJ3: view

Animal Models for FOXJ3 Gene

MGI Knock Outs for FOXJ3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FOXJ3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOXJ3 Gene

Localization for FOXJ3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXJ3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXJ3 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FOXJ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with FOXJ3: view

Pathways & Interactions for FOXJ3 Gene

SuperPathways for FOXJ3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXJ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0009653 anatomical structure morphogenesis IBA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with FOXJ3: view

No data available for Pathways by source and SIGNOR curated interactions for FOXJ3 Gene

Drugs & Compounds for FOXJ3 Gene

No Compound Related Data Available

Transcripts for FOXJ3 Gene

Unigene Clusters for FOXJ3 Gene

Forkhead box J3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FOXJ3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FOXJ3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1: - - -
SP2: - -
SP3:
SP4:

Relevant External Links for FOXJ3 Gene

GeneLoc Exon Structure for
FOXJ3
ECgene alternative splicing isoforms for
FOXJ3

Expression for FOXJ3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOXJ3 Gene

Protein differential expression in normal tissues from HIPED for FOXJ3 Gene

This gene is overexpressed in Ovary (21.1), Blymphocyte (18.7), Placenta (9.6), Testis (8.1), and NK cells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FOXJ3 Gene



Protein tissue co-expression partners for FOXJ3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FOXJ3 Gene:

FOXJ3

SOURCE GeneReport for Unigene cluster for FOXJ3 Gene:

Hs.26023

Evidence on tissue expression from TISSUES for FOXJ3 Gene

  • Nervous system(4.6)
  • Lung(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with FOXJ3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXJ3 Gene

Orthologs for FOXJ3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FOXJ3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXJ3 33 34
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia FOXJ3 33 34
  • 95.23 (n)
cow
(Bos Taurus)
Mammalia FOXJ3 33 34
  • 95.18 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 94 (a)
OneToMany
-- 34
  • 91 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia FOXJ3 34
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxj3 33 16 34
  • 92.27 (n)
rat
(Rattus norvegicus)
Mammalia Foxj3 33
  • 91.84 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia foxj3 33
  • 75.32 (n)
zebrafish
(Danio rerio)
Actinopterygii FOXJ3 34
  • 77 (a)
OneToOne
foxj3 33
  • 71.35 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
OneToOne
Species where no ortholog for FOXJ3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXJ3 Gene

ENSEMBL:
Gene Tree for FOXJ3 (if available)
TreeFam:
Gene Tree for FOXJ3 (if available)

Paralogs for FOXJ3 Gene

(12) SIMAP similar genes for FOXJ3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FOXJ3: view

Variants for FOXJ3 Gene

Sequence variations from dbSNP and Humsavar for FOXJ3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000000261 -- 42,265,511(+) AATTG(C/G)CATAT intron-variant
rs1000005230 -- 42,263,492(+) TATCT(C/T)TTTGT intron-variant
rs1000006415 -- 42,290,127(+) GTCTA(C/T)GTTAA intron-variant
rs1000071445 -- 42,218,778(+) CTGCA(A/C)AATTT intron-variant
rs1000072289 -- 42,313,369(+) AGAAT(C/T)GTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOXJ3 Gene

Variant ID Type Subtype PubMed ID
esv22111 CNV loss 19812545
esv24371 CNV loss 19812545
esv2539470 CNV deletion 19546169
esv2663676 CNV deletion 23128226
esv2747530 CNV deletion 23290073
esv3306125 CNV mobile element insertion 20981092
esv3375211 CNV insertion 20981092
esv3414902 CNV insertion 20981092
esv3561304 CNV deletion 23714750
esv3585840 CNV loss 21293372
esv3585842 CNV loss 21293372
nsv1133845 CNV deletion 24896259
nsv1143447 CNV deletion 24896259
nsv688 CNV insertion 18451855
nsv958710 CNV deletion 24416366

Variation tolerance for FOXJ3 Gene

Residual Variation Intolerance Score: 23.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.48; 64.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXJ3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXJ3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXJ3 Gene

Disorders for FOXJ3 Gene

Relevant External Links for FOXJ3

Genetic Association Database (GAD)
FOXJ3
Human Genome Epidemiology (HuGE) Navigator
FOXJ3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXJ3

No disorders were found for FOXJ3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXJ3 Gene

Publications for FOXJ3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 60
  4. Genome-wide binding studies reveal DNA binding specificity mechanisms and functional interplay amongst Forkhead transcription factors. (PMID: 26578569) Chen X … Sharrocks AD (Nucleic acids research 2016) 3 60
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X … Chen J (Molecular systems biology 2015) 3 60

Products for FOXJ3 Gene

Sources for FOXJ3 Gene

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