Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FOXJ3 Gene

Aliases for FOXJ3 Gene

  • Forkhead Box J3 2 3 5
  • KIAA1041 4

External Ids for FOXJ3 Gene

Previous GeneCards Identifiers for FOXJ3 Gene

  • GC01M042056
  • GC01M042311
  • GC01M042414
  • GC01M042642
  • GC01M040761

Summaries for FOXJ3 Gene

GeneCards Summary for FOXJ3 Gene

FOXJ3 (Forkhead Box J3) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXP3.

UniProtKB/Swiss-Prot for FOXJ3 Gene

  • Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXJ3 Gene

Genomics for FOXJ3 Gene

Regulatory Elements for FOXJ3 Gene

Enhancers for FOXJ3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FOXJ3 on UCSC Golden Path with GeneCards custom track

Genomic Location for FOXJ3 Gene

Chromosome:
1
Start:
42,176,539 bp from pter
End:
42,335,877 bp from pter
Size:
159,339 bases
Orientation:
Minus strand

Genomic View for FOXJ3 Gene

Genes around FOXJ3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXJ3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXJ3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXJ3 Gene

Proteins for FOXJ3 Gene

  • Protein details for FOXJ3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPW0-FOXJ3_HUMAN
    Recommended name:
    Forkhead box protein J3
    Protein Accession:
    Q9UPW0
    Secondary Accessions:
    • A7MBL7
    • A7MD18
    • D3DPW2
    • Q9NSS7

    Protein attributes for FOXJ3 Gene

    Size:
    622 amino acids
    Molecular mass:
    68960 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA82993.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FOXJ3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXJ3 Gene

Proteomics data for FOXJ3 Gene at MOPED

Post-translational modifications for FOXJ3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for FOXJ3

No data available for DME Specific Peptides for FOXJ3 Gene

Domains & Families for FOXJ3 Gene

Gene Families for FOXJ3 Gene

Protein Domains for FOXJ3 Gene

Suggested Antigen Peptide Sequences for FOXJ3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UPW0

UniProtKB/Swiss-Prot:

FOXJ3_HUMAN :
  • Contains 1 fork-head DNA-binding domain.
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXJ3: view

Function for FOXJ3 Gene

Molecular function for FOXJ3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration.

Gene Ontology (GO) - Molecular Function for FOXJ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with FOXJ3: view
genes like me logo Genes that share phenotypes with FOXJ3: view

Animal Models for FOXJ3 Gene

MGI Knock Outs for FOXJ3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOXJ3 Gene

Localization for FOXJ3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXJ3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXJ3 Gene COMPARTMENTS Subcellular localization image for FOXJ3 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for FOXJ3 Gene

Pathways & Interactions for FOXJ3 Gene

SuperPathways for FOXJ3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXJ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with FOXJ3: view

No data available for Pathways by source and SIGNOR curated interactions for FOXJ3 Gene

Drugs & Compounds for FOXJ3 Gene

No Compound Related Data Available

Transcripts for FOXJ3 Gene

Unigene Clusters for FOXJ3 Gene

Forkhead box J3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXJ3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1: - - -
SP2: - -
SP3:
SP4:

Relevant External Links for FOXJ3 Gene

GeneLoc Exon Structure for
FOXJ3
ECgene alternative splicing isoforms for
FOXJ3

Expression for FOXJ3 Gene

mRNA expression in normal human tissues for FOXJ3 Gene

Protein differential expression in normal tissues from HIPED for FOXJ3 Gene

This gene is overexpressed in Ovary (21.1), Blymphocyte (18.7), Placenta (9.6), Testis (8.1), and NK cells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FOXJ3 Gene



SOURCE GeneReport for Unigene cluster for FOXJ3 Gene Hs.26023

genes like me logo Genes that share expression patterns with FOXJ3: view

Protein tissue co-expression partners for FOXJ3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FOXJ3 Gene

Orthologs for FOXJ3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FOXJ3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOXJ3 35
  • 95.18 (n)
  • 97.43 (a)
FOXJ3 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXJ3 35
  • 95.23 (n)
  • 96.95 (a)
FOXJ3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxj3 35
  • 92.27 (n)
  • 94.69 (a)
Foxj3 16
Foxj3 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FOXJ3 35
  • 99.68 (n)
  • 99.84 (a)
FOXJ3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxj3 35
  • 91.84 (n)
  • 95.33 (a)
oppossum
(Monodelphis domestica)
Mammalia FOXJ3 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 94 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia foxj3 35
  • 75.32 (n)
  • 77.22 (a)
zebrafish
(Danio rerio)
Actinopterygii foxj3 35
  • 71.35 (n)
  • 77.58 (a)
FOXJ3 36
  • 77 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToOne
Species with no ortholog for FOXJ3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXJ3 Gene

ENSEMBL:
Gene Tree for FOXJ3 (if available)
TreeFam:
Gene Tree for FOXJ3 (if available)

Paralogs for FOXJ3 Gene

(12) SIMAP similar genes for FOXJ3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FOXJ3: view

Variants for FOXJ3 Gene

Sequence variations from dbSNP and Humsavar for FOXJ3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs343376 - 42,227,926(-) AGATG(C/T)GCTGC reference, missense
rs1139978 - 42,191,525(-) TGCAC(A/C)CACAG reference, missense
rs163850 -- 42,231,010(-) taagg(C/T)tgagt intron-variant
rs163851 -- 42,230,954(-) cttca(A/G)tgcac intron-variant
rs163852 -- 42,230,409(-) atctg(A/G)tatcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOXJ3 Gene

Variant ID Type Subtype PubMed ID
nsv688 CNV Insertion 18451855
esv2663676 CNV Deletion 23128226
esv24371 CNV Loss 19812545
nsv871007 CNV Loss 21882294
esv22111 CNV Loss 19812545
esv2539470 CNV Deletion 19546169
esv2747530 CNV Deletion 23290073
esv270402 CNV Insertion 20981092
nsv870704 CNV Gain 21882294

Variation tolerance for FOXJ3 Gene

Residual Variation Intolerance Score: 23.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.48; 64.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXJ3 Gene

HapMap Linkage Disequilibrium report
FOXJ3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXJ3 Gene

Disorders for FOXJ3 Gene

Relevant External Links for FOXJ3

Genetic Association Database (GAD)
FOXJ3
Human Genome Epidemiology (HuGE) Navigator
FOXJ3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXJ3

No disorders were found for FOXJ3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXJ3 Gene

Publications for FOXJ3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. MiR-517a-3p accelerates lung cancer cell proliferation and invasion through inhibiting FOXJ3 expression. (PMID: 24846831) Jin J. … Zhang B. (Life Sci. 2014) 3
  4. Association of forkhead box J3 (FOXJ3) polymorphisms with rheumatoid arthritis. (PMID: 23933633) Ban J.Y. … Hong S.J. (Mol Med Rep 2013) 3
  5. Live-cell monitoring of periodic gene expression in synchronous human cells identifies Forkhead genes involved in cell cycle control. (PMID: 22740631) Grant G.D. … Whitfield M.L. (Mol. Biol. Cell 2012) 3

Products for FOXJ3 Gene

Sources for FOXJ3 Gene

Content