FOXJ2 Gene
protein-coding GIFtS: 48
GCID: GC12P008185
|
|
forkhead box J2
| |
Aliases
for FOXJ2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Forkhead Box J21 2 | | FHX1 2 3 | | Fork Head Homologous X2 3 | | Forkhead Box Protein J22 | | FOXJ2 Forkhead Factor2 |
Export aliases for FOXJ2 gene to outside databasesPrevious GC identifers: GC12P008078 GC12P008079 GC12P007996 |
Summaries
for FOXJ2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FOXJ2_HUMAN, Q9P0K8Function: Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behavesas a more potent transactivator than FOXJ2.S
Gene Wiki entry for FOXJ2
|
Genomic Views
for FOXJ2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009714.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FOXJ2 gene promoter:
HOXA9B HOXA9 Elk-1 NF-kappaB Meis-1b YY1 Nkx6-1 FOXO4 NF-kappaB1 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FOXJ2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXJ2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13.31 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.31FOXJ2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P008185: view genomic region
(about GC identifiers)
Start:
|
8,185,299 bp from pter |
End:
|
8,208,118 bp from pter |
Size:
|
22,820 bases |
Orientation:
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plus strand |
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Proteins
for FOXJ2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FOXJ2_HUMAN, Q9P0K8 (See
protein sequence)Recommended Name: Forkhead box protein J2 Size: 574 amino acids; 62395 Da
Subcellular location: Nucleus
Secondary accessions: A0AVK4 B2RMP3 Q96PS9 Q9NSN5Alternative splicing: 2 isoforms: Q9P0K8-1 Q9P0K8-2 Explore the universe of human proteins at neXtProt for FOXJ2: NX_Q9P0K8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P0K8
FOXJ2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060886.1
ENSEMBL proteins: ENSP00000162391 ENSP00000403411
Human Recombinant Protein Products for FOXJ2:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
FOXJ2 for ontologies About GeneDecksing
FOXJ2 Antibody Products:
Assay Products for FOXJ2: |
Protein
Domains /
Families
for FOXJ2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FOXJ2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9P0K8ProtoNet protein and cluster: Q9P0K8 UniProtKB/Swiss-Prot: FOXJ2_HUMAN, Q9P0K8Similarity: Contains 1 fork-head DNA-binding domain |
Function
for FOXJ2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: FOXJ2_HUMAN, Q9P0K8Function: Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behavesas a more potent transactivator than FOXJ2.S Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003690 | double-stranded DNA binding |
IBA | -- | | GO:0003705 | RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity |
IBA | -- | | GO:0008134 | transcription factor binding |
IBA | -- | | GO:0008301 | DNA binding, bending |
IBA | -- | | GO:0019904 | protein domain specific binding |
IBA | -- |
FOXJ2 for ontologies About GeneDecksing
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXJ2
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXJ2 |
|
Pathways & Interactions
for FOXJ2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOXJ2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for FOXJ2 (Q9P0K83 ENSP000001623914) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
FOXJ2 for ontologies About GeneDecksing
|
Drugs & Compounds
for FOXJ2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FOXJ2
Search CenterWatch for drugs/clinical trials and news about FOXJ2
|
Transcripts
for FOXJ2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FOXJ2 gene: NM_018416.2 Unigene Cluster for FOXJ2: Forkhead box J2 Hs.120844 [show with all ESTs]Unigene Representative Sequence: NM_0184163 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000162391(uc001qtu.3) ENST00000428177(uc001qtt.1) ENST00000539192
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXJ2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXJ2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FOXJ2 (NM_018416) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOXJ2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXJ2 |
Additional cDNA sequence: AF038177.1 AF155132.1 AK092529.1 AL161978.1 BC126396.1 BC136305.1 4 DOTS entries: DT.442345 DT.97764578 DT.95078982 DT.100661595 24/138 AceView cDNA sequences (see all 138): F04482 CB160852 BM672524 AF038177 H40753 BE327999 AI251855 BU077931 AK092529 AW614659 BQ421579 CD629260 BE673701 AI092926 AI076279 AL703544 T23034 NM_018416 BF438556 BM473835 AA806883 AA565197 U25903 BM905652
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for FOXJ2 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FOXJ2
|
Expression
for FOXJ2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FOXJ2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTCTTAAT
About this image
See FOXJ2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FOXJ2
SOURCE GeneReport for Unigene cluster: Hs.120844
UniProtKB/Swiss-Prot: FOXJ2_HUMAN, Q9P0K8Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for FOXJ2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOXJ2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FOXJ2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXJ2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXJ2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXJ2 |
Orthologs
for FOXJ2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FOXJ2 gene from 3/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FOXJ21 |
forkhead box J2 |
78.09(n)
84.26(a) |
|
418259 XM_416484.3 XP_416484.2 |
lizard
(Anolis carolinensis) |
Reptilia |
FOXJ26 |
-- |
81(a) |
1 ↔ 1 |
GL343236.1(1228527-1248314) |
zebrafish
(Danio rerio) |
Actinopterygii |
si:dkey-38o19.86 |
si:dkey-38o19.8 |
18(a) |
possible ortholog |
16(14509915-14538450) |
ENSEMBL Gene Tree for FOXJ2 (if available)
TreeFam Gene Tree for FOXJ2 (if available) |
Paralogs
for FOXJ2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FOXJ2 gene
- FOXJ12 FOXN32 FOXK12 FOXN42 FOXN12 FOXK22 FOXP42 FOXG12
- FOXJ32 FOXP22 FOXN22 FOXP32 FOXP12
1 SIMAP similar gene for FOXJ2 using alignment to 1 protein entry: FOXJ2_HUMAN:FOXJ3
FOXJ2 for paralogs About GeneDecksing
|
Genomic Variants
for FOXJ2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FOXJ2 (8185299 - 8208118 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for FOXJ2
3 CNVs: 3873 34469 8710 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOXJ2 |
|
Disorders
/ Diseases
for FOXJ2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FOXJ2 for disorders About GeneDecksing
5  diseases for FOXJ2: About MalaCardslymphedema hepatitis b meningioma hepatitis
leukemia
Human Genome Epidemiology (HuGE) Navigator: FOXJ2 (6 documents)
Export disorders for FOXJ2 gene to outside databases
|
Publications
for FOXJ2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FOXJ2 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with FOXJ2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- FHX.L and FHX.S, two isoforms of the human fork-head factor FHX (FOXJ2) with differential activity. (PubMed id 10966786)1, 2, 3, 9 Perez-Sanchez C.... Rey-Campos J. (2000)
- FHX, a novel fork head factor with a dual DNA binding specificity. (PubMed id 10777590)1, 2, 3 Perez-Sanchez C.... Rey-Campos J. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Overexpression of forkhead box J2 can decrease the mig ration of breast cancer cells. (PubMed id 22441887)1 Wang Y....Cheng C. (2012)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1 Han S....Kang D. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1 Rajaraman P....Inskip P.D. (2010)
- Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)
|
External Searches for FOXJ2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FOXJ2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FOXJ2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FOXJ2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FOXJ2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FOXJ2 gene:
Search GeneIP for patents involving FOXJ2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FOXJ2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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