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Aliases for FOXJ2 Gene

Aliases for FOXJ2 Gene

  • Forkhead Box J2 2 3 5
  • Fork Head Homologous X 3 4
  • FHX 3 4
  • FOXJ2 Forkhead Factor 3

External Ids for FOXJ2 Gene

Previous GeneCards Identifiers for FOXJ2 Gene

  • GC12P008078
  • GC12P008079
  • GC12P008185
  • GC12P007996

Summaries for FOXJ2 Gene

GeneCards Summary for FOXJ2 Gene

FOXJ2 (Forkhead Box J2) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is FOXP3.

UniProtKB/Swiss-Prot for FOXJ2 Gene

  • Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S.

Gene Wiki entry for FOXJ2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXJ2 Gene

Genomics for FOXJ2 Gene

Regulatory Elements for FOXJ2 Gene

Promoters for FOXJ2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FOXJ2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FOXJ2 Gene

Chromosome:
12
Start:
8,032,703 bp from pter
End:
8,055,522 bp from pter
Size:
22,820 bases
Orientation:
Plus strand

Genomic View for FOXJ2 Gene

Genes around FOXJ2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXJ2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXJ2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXJ2 Gene

Proteins for FOXJ2 Gene

  • Protein details for FOXJ2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0K8-FOXJ2_HUMAN
    Recommended name:
    Forkhead box protein J2
    Protein Accession:
    Q9P0K8
    Secondary Accessions:
    • A0AVK4
    • B2RMP3
    • Q96PS9
    • Q9NSN5

    Protein attributes for FOXJ2 Gene

    Size:
    574 amino acids
    Molecular mass:
    62395 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FOXJ2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXJ2 Gene

Proteomics data for FOXJ2 Gene at MOPED

Post-translational modifications for FOXJ2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXJ2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FOXJ2 Gene

Domains & Families for FOXJ2 Gene

Gene Families for FOXJ2 Gene

Protein Domains for FOXJ2 Gene

Suggested Antigen Peptide Sequences for FOXJ2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P0K8

UniProtKB/Swiss-Prot:

FOXJ2_HUMAN :
  • Contains 1 fork-head DNA-binding domain.
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXJ2: view

Function for FOXJ2 Gene

Molecular function for FOXJ2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S.

Gene Ontology (GO) - Molecular Function for FOXJ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IEA,IDA 10777590
genes like me logo Genes that share ontologies with FOXJ2: view

Phenotypes for FOXJ2 Gene

genes like me logo Genes that share phenotypes with FOXJ2: view

Animal Model Products

Transcription Factor Targets for FOXJ2 Gene

Selected GeneGlobe predicted Target genes for FOXJ2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and HOMER Transcription for FOXJ2 Gene

Localization for FOXJ2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXJ2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXJ2 Gene COMPARTMENTS Subcellular localization image for FOXJ2 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for FOXJ2 Gene

Pathways & Interactions for FOXJ2 Gene

SuperPathways for FOXJ2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXJ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with FOXJ2: view

No data available for Pathways by source and SIGNOR curated interactions for FOXJ2 Gene

Drugs & Compounds for FOXJ2 Gene

No Compound Related Data Available

Transcripts for FOXJ2 Gene

Unigene Clusters for FOXJ2 Gene

Forkhead box J2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXJ2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1:
SP2:
SP3: - - -
SP4: - - -
SP5:

Relevant External Links for FOXJ2 Gene

GeneLoc Exon Structure for
FOXJ2
ECgene alternative splicing isoforms for
FOXJ2

Expression for FOXJ2 Gene

mRNA expression in normal human tissues for FOXJ2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FOXJ2 Gene

This gene is overexpressed in Fetal gut (16.3), Blymphocyte (12.6), Pancreas (10.8), and CD8 Tcells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FOXJ2 Gene



SOURCE GeneReport for Unigene cluster for FOXJ2 Gene Hs.120844

mRNA Expression by UniProt/SwissProt for FOXJ2 Gene

Q9P0K8-FOXJ2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with FOXJ2: view

Protein tissue co-expression partners for FOXJ2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FOXJ2 Gene

Orthologs for FOXJ2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FOXJ2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOXJ2 35
  • 87.2 (n)
  • 90.36 (a)
FOXJ2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXJ2 35
  • 91.83 (n)
  • 92.82 (a)
FOXJ2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxj2 35
  • 87.08 (n)
  • 89.56 (a)
Foxj2 16
Foxj2 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FOXJ2 35
  • 99.3 (n)
  • 99.13 (a)
FOXJ2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxj2 35
  • 86.51 (n)
  • 88.97 (a)
oppossum
(Monodelphis domestica)
Mammalia FOXJ2 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOXJ2 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOXJ2 35
  • 77.78 (n)
  • 83.7 (a)
FOXJ2 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXJ2 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia foxj2 35
  • 63.81 (n)
  • 59.9 (a)
zebrafish
(Danio rerio)
Actinopterygii foxj2 36
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
ManyToMany
Species with no ortholog for FOXJ2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXJ2 Gene

ENSEMBL:
Gene Tree for FOXJ2 (if available)
TreeFam:
Gene Tree for FOXJ2 (if available)

Paralogs for FOXJ2 Gene

(1) SIMAP similar genes for FOXJ2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXJ2: view

Variants for FOXJ2 Gene

Sequence variations from dbSNP and Humsavar for FOXJ2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2277415 - 8,047,992(+) CACAG(C/T)CACCT reference, missense
rs35642012 - 8,044,828(-) GGAGG(C/G)GGACC reference, synonymous-codon
rs14586 -- 8,055,319(-) TCTAT(A/G)CCAAA utr-variant-3-prime
rs734322 -- 8,040,801(-) agtga(C/G)tggaa intron-variant
rs722457 -- 8,051,893(+) GTCTT(G/T)TTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOXJ2 Gene

Variant ID Type Subtype PubMed ID
dgv455e1 CNV Complex 17122850
nsv428270 CNV Gain 18775914
esv2751118 CNV Gain 17911159
nsv898729 CNV Gain 21882294
nsv898732 CNV Loss 21882294

Variation tolerance for FOXJ2 Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXJ2 Gene

HapMap Linkage Disequilibrium report
FOXJ2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXJ2 Gene

Disorders for FOXJ2 Gene

Relevant External Links for FOXJ2

Genetic Association Database (GAD)
FOXJ2
Human Genome Epidemiology (HuGE) Navigator
FOXJ2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXJ2

No disorders were found for FOXJ2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXJ2 Gene

Publications for FOXJ2 Gene

  1. FHX.L and FHX.S, two isoforms of the human fork-head factor FHX (FOXJ2) with differential activity. (PMID: 10966786) Perez-Sanchez C. … Rey-Campos J. (J. Mol. Biol. 2000) 2 3 4 23 67
  2. FHX, a novel fork head factor with a dual DNA binding specificity. (PMID: 10777590) Perez-Sanchez C. … Rey-Campos J. (J. Biol. Chem. 2000) 2 3
  3. STAT6 silencing up-regulates cholesterol synthesis via miR-197/FOXJ2 axis and induces ER stress-mediated apoptosis in lung cancer cells. (PMID: 25451482) Dubey R. … Saini N. (Biochim. Biophys. Acta 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. MicroRNA-34a targets Forkhead box j2 to modulate differentiation of endothelial progenitor cells in response to shear stress. (PMID: 24792364) Cheng B.B. … Jiang Z.L. (J. Mol. Cell. Cardiol. 2014) 3

Products for FOXJ2 Gene

Sources for FOXJ2 Gene

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