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Aliases for FOXJ1 Gene

Aliases for FOXJ1 Gene

  • Forkhead Box J1 2 3 5
  • Hepatocyte Nuclear Factor 3 Forkhead Homolog 4 3 4
  • Forkhead-Related Protein FKHL13 3 4
  • FKHL13 3 4
  • HFH-4 3 4
  • HFH4 3 4
  • Forkhead Transcription Factor HFH-4 3
  • Fork Head Homologue 4 3
  • Forkhead-Like 13 3

External Ids for FOXJ1 Gene

Previous HGNC Symbols for FOXJ1 Gene

  • FKHL13

Previous GeneCards Identifiers for FOXJ1 Gene

  • GC17M073990
  • GC17M077124
  • GC17M074596
  • GC17M074729
  • GC17M071644
  • GC17M074132
  • GC17M069561

Summaries for FOXJ1 Gene

Entrez Gene Summary for FOXJ1 Gene

  • This gene encodes a member of the forkhead family of transcription factors. Similar genes in zebrafish and mouse have been shown to regulate the transcription of genes that control the production of motile cilia. The mouse ortholog also functions in the determination of left-right asymmetry. Polymorphisms in this gene are associated with systemic lupus erythematosus and allergic rhinitis.[provided by RefSeq, Sep 2009]

GeneCards Summary for FOXJ1 Gene

FOXJ1 (Forkhead Box J1) is a Protein Coding gene. Diseases associated with FOXJ1 include allergic rhinitis and rhinitis. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXP3.

UniProtKB/Swiss-Prot for FOXJ1 Gene

  • Transcription factor required for motile ciliogenesis.

Gene Wiki entry for FOXJ1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXJ1 Gene

Genomics for FOXJ1 Gene

Regulatory Elements for FOXJ1 Gene

Promoters for FOXJ1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FOXJ1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FOXJ1 Gene

Chromosome:
17
Start:
76,136,333 bp from pter
End:
76,141,299 bp from pter
Size:
4,967 bases
Orientation:
Minus strand

Genomic View for FOXJ1 Gene

Genes around FOXJ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXJ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXJ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXJ1 Gene

Proteins for FOXJ1 Gene

  • Protein details for FOXJ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92949-FOXJ1_HUMAN
    Recommended name:
    Forkhead box protein J1
    Protein Accession:
    Q92949
    Secondary Accessions:
    • O00630

    Protein attributes for FOXJ1 Gene

    Size:
    421 amino acids
    Molecular mass:
    45247 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXJ1 Gene

Proteomics data for FOXJ1 Gene at MOPED

Post-translational modifications for FOXJ1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXJ1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FOXJ1 Gene

Domains & Families for FOXJ1 Gene

Gene Families for FOXJ1 Gene

Protein Domains for FOXJ1 Gene

Suggested Antigen Peptide Sequences for FOXJ1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92949

UniProtKB/Swiss-Prot:

FOXJ1_HUMAN :
  • Contains 1 fork-head DNA-binding domain.
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXJ1: view

Function for FOXJ1 Gene

Molecular function for FOXJ1 Gene

GENATLAS Biochemistry:
transcription factor-like 13,with a Drosophila homeo forkhead DNA binding domain,mouse hepatocyte nuclear factor 3 homolog,expression confined to cilia/flagella producing cells
UniProtKB/Swiss-Prot Function:
Transcription factor required for motile ciliogenesis.
genes like me logo Genes that share phenotypes with FOXJ1: view

Animal Models for FOXJ1 Gene

MGI Knock Outs for FOXJ1:

Animal Model Products

miRNA for FOXJ1 Gene

miRTarBase miRNAs that target FOXJ1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOXJ1 Gene

Localization for FOXJ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXJ1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXJ1 Gene COMPARTMENTS Subcellular localization image for FOXJ1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2

No data available for Gene Ontology (GO) - Cellular Components for FOXJ1 Gene

Pathways & Interactions for FOXJ1 Gene

genes like me logo Genes that share pathways with FOXJ1: view

Pathways by source for FOXJ1 Gene

Gene Ontology (GO) - Biological Process for FOXJ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0002635 negative regulation of germinal center formation IEA,ISS --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0007283 spermatogenesis NAS 9073514
GO:0007368 determination of left/right symmetry IEA --
genes like me logo Genes that share ontologies with FOXJ1: view

No data available for SIGNOR curated interactions for FOXJ1 Gene

Drugs & Compounds for FOXJ1 Gene

No Compound Related Data Available

Transcripts for FOXJ1 Gene

mRNA/cDNA for FOXJ1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(68) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXJ1 Gene

Forkhead box J1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXJ1 Gene

No ASD Table

Relevant External Links for FOXJ1 Gene

GeneLoc Exon Structure for
FOXJ1
ECgene alternative splicing isoforms for
FOXJ1

Expression for FOXJ1 Gene

mRNA expression in normal human tissues for FOXJ1 Gene

mRNA differential expression in normal tissues according to GTEx for FOXJ1 Gene

This gene is overexpressed in Fallopian Tube (x9.2), Testis (x7.5), Cervix - Endocervix (x6.7), Brain - Caudate (basal ganglia) (x4.1), and Brain - Hypothalamus (x4.0).

SOURCE GeneReport for Unigene cluster for FOXJ1 Gene Hs.651204

mRNA Expression by UniProt/SwissProt for FOXJ1 Gene

Q92949-FOXJ1_HUMAN
Tissue specificity: Testis, oviduct, lung and brain cortex.
genes like me logo Genes that share expression patterns with FOXJ1: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for FOXJ1 Gene

Orthologs for FOXJ1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FOXJ1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOXJ1 35
  • 93.27 (n)
  • 95.72 (a)
FOXJ1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXJ1 35
  • 91.69 (n)
  • 93.59 (a)
FOXJ1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxj1 35
  • 88.04 (n)
  • 92.64 (a)
Foxj1 16
Foxj1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FOXJ1 35
  • 99.52 (n)
  • 99.76 (a)
FOXJ1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxj1 35
  • 87.97 (n)
  • 92.16 (a)
oppossum
(Monodelphis domestica)
Mammalia FOXJ1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOXJ1 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOXJ1 35
  • 71.06 (n)
  • 68.05 (a)
lizard
(Anolis carolinensis)
Reptilia FOXJ1 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia foxj1 35
  • 66.26 (n)
  • 65.37 (a)
Str.533 35
African clawed frog
(Xenopus laevis)
Amphibia foxJ1 35
zebrafish
(Danio rerio)
Actinopterygii foxj1a 35
  • 63.07 (n)
  • 62.78 (a)
foxj1a 36
  • 50 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FKH1 36
  • 13 (a)
ManyToMany
FKH2 36
  • 11 (a)
ManyToMany
FKH2 38
Species with no ortholog for FOXJ1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXJ1 Gene

ENSEMBL:
Gene Tree for FOXJ1 (if available)
TreeFam:
Gene Tree for FOXJ1 (if available)

Paralogs for FOXJ1 Gene

genes like me logo Genes that share paralogs with FOXJ1: view

Variants for FOXJ1 Gene

Sequence variations from dbSNP and Humsavar for FOXJ1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs894542 -- 76,137,893(-) CTGAC(A/G)GTGAA reference, synonymous-codon
rs1868824 -- 76,138,547(-) GCCCA(C/G)CCCCC intron-variant
rs1052044 -- 76,137,262(-) ACCTA(G/T)GCAGG utr-variant-3-prime
rs1052045 -- 76,137,226(-) CCCCA(A/G)AGGCC utr-variant-3-prime
rs1052046 -- 76,137,137(-) CTCCT(C/T)TCCCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FOXJ1 Gene

Variant ID Type Subtype PubMed ID
nsv908824 CNV Loss 21882294
nsv833546 CNV Loss 17160897
dgv3270n71 CNV Loss 21882294

Variation tolerance for FOXJ1 Gene

Residual Variation Intolerance Score: 85.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.09; 38.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXJ1 Gene

HapMap Linkage Disequilibrium report
FOXJ1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXJ1 Gene

Disorders for FOXJ1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for FOXJ1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
allergic rhinitis
  • atopic rhinitis
rhinitis
  • runny nose
primary ciliary dyskinesia
  • kartagener syndrome
visceral heterotaxy
  • heterotaxia
kartagener syndrome
  • kartagener's syndrome
- elite association - COSMIC cancer census association via MalaCards
Search FOXJ1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FOXJ1_HUMAN
  • Allergic rhinitis (ALRH) [MIM:607154]: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Relevant External Links for FOXJ1

Genetic Association Database (GAD)
FOXJ1
Human Genome Epidemiology (HuGE) Navigator
FOXJ1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXJ1
genes like me logo Genes that share disorders with FOXJ1: view

No data available for Genatlas for FOXJ1 Gene

Publications for FOXJ1 Gene

  1. Identification of single nucleotide polymorphisms in FOXJ1 and their association with allergic rhinitis. (PMID: 16518568) Li C.-S. … Chung H.-T. (J. Hum. Genet. 2006) 2 3 4 48 67
  2. The human hepatocyte nuclear factor 3/fork head gene FKHL13: genomic structure and pattern of expression. (PMID: 9073514) Murphy D.B. … Thies U. (Genomics 1997) 2 3 23
  3. No deleterious mutations in the FOXJ1 (alias HFH-4) gene in patients with primary ciliary dyskinesia (PCD). (PMID: 11060460) Maiti A.K. … Antonarakis S.E. (Cytogenet. Cell Genet. 2000) 3 23
  4. A human forkhead/winged-helix transcription factor expressed in developing pulmonary and renal epithelium. (PMID: 9530170) Pelletier G.J. … Hackett B.P. (Am. J. Physiol. 1998) 3 23
  5. The winged helix transcription factor HFH-4 is expressed during choroid plexus epithelial development in the mouse embryo. (PMID: 9096351) Lim L. … Costa R.H. (Proc. Natl. Acad. Sci. U.S.A. 1997) 3 23

Products for FOXJ1 Gene

Sources for FOXJ1 Gene

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