FOXI3 Gene
protein-coding GIFtS: 34
GCID: GC02M088747
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forkhead box I3
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Aliases
for FOXI3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Forkhead Box I31 2 | | Forkhead Box Protein I32 |
Export aliases for FOXI3 gene to outside databasesPrevious GC identifers: GC02M088520 GC02M087669 |
Summaries
for FOXI3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FOXI3_HUMAN, A8MTJ6Function: Possible transcriptional factor (By similarity)
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Genomic Views
for FOXI3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FOXI3 gene promoter:
HOXA9B COUP-TF1 Elk-1 COUP HNF-4alpha2 HNF-4alpha1 Evi-1 PPAR-gamma1 COUP-TF PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for FOXI3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXI3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p11.2 Ensembl cytogenetic band: 2p11.2 HGNC cytogenetic band: 2p11.2FOXI3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M088747: view genomic region
(about GC identifiers)
Start:
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88,747,726 bp from pter |
End:
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88,752,131 bp from pter |
Size:
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4,406 bases |
Orientation:
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minus strand |
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Proteins
for FOXI3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FOXI3_HUMAN, A8MTJ6 (See
protein sequence)Recommended Name: Forkhead box protein I3 Size: 420 amino acids; 43326 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B5RI09Explore the universe of human proteins at neXtProt for FOXI3: NX_A8MTJ6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A8MTJ6
FOXI3 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001129121.1
Human Recombinant Protein Products for FOXI3:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005667 | transcription factor complex |
IBA | -- |
FOXI3 for ontologies About GeneDecksing
FOXI3 Antibody Products:
Assay Products for FOXI3: |
Protein
Domains /
Families
for FOXI3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FOXI3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A8MTJ6ProtoNet protein and cluster: A8MTJ6 UniProtKB/Swiss-Prot: FOXI3_HUMAN, A8MTJ6Similarity: Contains 1 fork-head DNA-binding domain |
Function
for FOXI3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: FOXI3_HUMAN, A8MTJ6Function: Possible transcriptional factor (By similarity) Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003690 | double-stranded DNA binding |
IBA | -- | | GO:0003705 | RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity |
IBA | -- | | GO:0008134 | transcription factor binding |
IBA | -- | | GO:0008301 | DNA binding, bending |
IBA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
FOXI3 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for FOXI3:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXI3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXI3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FOXI3 (NM_001135649) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOXI3 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FOXI3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXI3 |
|
Pathways & Interactions
for FOXI3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOXI3
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007389 | pattern specification process |
IBA | -- | | GO:0009957 | epidermal cell fate specification |
IBA | -- | | GO:0043049 | otic placode formation |
IBA | -- | | GO:0051090 | regulation of sequence-specific DNA binding transcription factor activity |
IBA | -- |
FOXI3 for ontologies About GeneDecksing
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Drugs & Compounds
for FOXI3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FOXI3
Search CenterWatch for drugs/clinical trials and news about FOXI3
|
Transcripts
for FOXI3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FOXI3 gene: NM_001135649.1 Unigene Cluster for FOXI3: Forkhead box I3 Hs.716722 [show with all ESTs]Unigene Representative Sequence: NM_0011356492 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000398142 ENST00000428390(uc010ytq.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXI3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXI3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FOXI3 (NM_001135649) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOXI3 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FOXI3 |
1 DOTS entry: DT.91670557 1 AceView cDNA sequence: AA349674
GeneLoc Exon Structure
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Expression
for FOXI3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FOXI3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGAACAGCC
About this image
SOURCE GeneReport for Unigene cluster: Hs.716722
SABiosciences Custom PCR Arrays for FOXI3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOXI3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FOXI3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXI3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXI3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXI3 |
Orthologs
for FOXI3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FOXI3 gene from 3/8 species (see all 8) About this table
ENSEMBL Gene Tree for FOXI3 (if available)
TreeFam Gene Tree for FOXI3 (if available) |
Paralogs
for FOXI3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FOXI3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FOXI3 (88747726 - 88752131 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FOXI3: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for FOXI3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 FOXI3 for disorders About MalaCards
FOXI3 for disorders About GeneDecksing
OMIM gene information: 612351
OMIM disorders: --
Export disorders for FOXI3 gene to outside databases
|
Publications
for FOXI3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FOXI3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FOXI3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A mutation in hairless dogs implicates FOXI3 in ectodermal development. (PubMed id 18787161)1, 2, 3 Droegemueller C.... Leeb T. (2008)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
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External Searches for FOXI3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing FOXI3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FOXI3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FOXI3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FOXI3 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for FOXI3 gene:
Search GeneIP for patents involving FOXI3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FOXI3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FOXI3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOXI3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOXI3 | | | OriGene Protein Over-expression Lysate for FOXI3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FOXI3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXI3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXI3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FOXI3 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOXI3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXI3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXI3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXI3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXI3 |
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 | | | FOXI3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXI3 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for FOXI3 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FOXI3 |
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