Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FOXI3 Gene

Aliases for FOXI3 Gene

  • Forkhead Box I3 2 3 5

External Ids for FOXI3 Gene

Previous GeneCards Identifiers for FOXI3 Gene

  • GC02M088520
  • GC02M088747
  • GC02M087669

Summaries for FOXI3 Gene

GeneCards Summary for FOXI3 Gene

FOXI3 (Forkhead Box I3) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is FOXI1.

UniProtKB/Swiss-Prot for FOXI3 Gene

  • Possible transcriptional factor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXI3 Gene

Genomics for FOXI3 Gene

Regulatory Elements for FOXI3 Gene

Enhancers for FOXI3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F088503 0.6 FANTOM5 3.2 -51.1 -51101 0.4 POLR2H PKNOX1 NFYB GTF2A2 TEX37 EIF2AK3 FOXI3 PIR49195 GC02M088487
GH02F088442 0.6 ENCODE 0.4 +9.1 9104 2.3 ZNF316 MAFG POU5F1 NFE2 EMSY MAFK TEX37 RNU6-1007P LOC101928403 FOXI3 ENSG00000224291
GH02F088443 0.2 ENCODE 0.4 +10.4 10380 0.2 RNU6-1007P ENSG00000224291 FOXI3
GH02F088471 0.2 ENCODE 0.3 -19.1 -19105 0.6 RPIA FOXI3 GC02M088487
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FOXI3 on UCSC Golden Path with GeneCards custom track

Promoters for FOXI3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001824877 156 1001 PKNOX1 SUZ12 RNF2 ZBTB8A E2F1 CBX8 GLIS2 HDAC2 SCRT2 KLF9

Genomic Location for FOXI3 Gene

Chromosome:
2
Start:
88,446,787 bp from pter
End:
88,452,656 bp from pter
Size:
5,870 bases
Orientation:
Minus strand

Genomic View for FOXI3 Gene

Genes around FOXI3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXI3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXI3 Gene

Proteins for FOXI3 Gene

  • Protein details for FOXI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MTJ6-FOXI3_HUMAN
    Recommended name:
    Forkhead box protein I3
    Protein Accession:
    A8MTJ6
    Secondary Accessions:
    • B5RI09

    Protein attributes for FOXI3 Gene

    Size:
    420 amino acids
    Molecular mass:
    43326 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXI3 Gene

Post-translational modifications for FOXI3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXI3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXI3 Gene

Domains & Families for FOXI3 Gene

Protein Domains for FOXI3 Gene

Suggested Antigen Peptide Sequences for FOXI3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MTJ6

UniProtKB/Swiss-Prot:

FOXI3_HUMAN :
  • Contains 1 fork-head DNA-binding domain.
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXI3: view

No data available for Gene Families for FOXI3 Gene

Function for FOXI3 Gene

Molecular function for FOXI3 Gene

UniProtKB/Swiss-Prot Function:
Possible transcriptional factor.

Gene Ontology (GO) - Molecular Function for FOXI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXI3: view
genes like me logo Genes that share phenotypes with FOXI3: view

Animal Models for FOXI3 Gene

MGI Knock Outs for FOXI3:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FOXI3 Gene

Localization for FOXI3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXI3 Gene

Gene Ontology (GO) - Cellular Components for FOXI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with FOXI3: view

No data available for Subcellular locations from COMPARTMENTS for FOXI3 Gene

Pathways & Interactions for FOXI3 Gene

SuperPathways for FOXI3 Gene

No Data Available

Interacting Proteins for FOXI3 Gene

Selected Interacting proteins: A8MTJ6-FOXI3_HUMAN for FOXI3 Gene via IID

Gene Ontology (GO) - Biological Process for FOXI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with FOXI3: view

No data available for Pathways by source and SIGNOR curated interactions for FOXI3 Gene

Transcripts for FOXI3 Gene

mRNA/cDNA for FOXI3 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXI3 Gene

Forkhead box I3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXI3 Gene

No ASD Table

Relevant External Links for FOXI3 Gene

GeneLoc Exon Structure for
FOXI3
ECgene alternative splicing isoforms for
FOXI3

Expression for FOXI3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FOXI3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXI3 Gene

This gene is overexpressed in Testis (x21.8), Skin - Not Sun Exposed (Suprapubic) (x9.2), Pituitary (x6.2), and Skin - Sun Exposed (Lower leg) (x5.7).

NURSA nuclear receptor signaling pathways regulating expression of FOXI3 Gene:

FOXI3

SOURCE GeneReport for Unigene cluster for FOXI3 Gene:

Hs.716722
genes like me logo Genes that share expression patterns with FOXI3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FOXI3 Gene

Orthologs for FOXI3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FOXI3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXI3 34
  • 98.56 (n)
cow
(Bos Taurus)
Mammalia FOXI3 34
  • 85.71 (n)
dog
(Canis familiaris)
Mammalia FOXI3 34
  • 83.97 (n)
mouse
(Mus musculus)
Mammalia Foxi3 34 16
  • 79.55 (n)
rat
(Rattus norvegicus)
Mammalia Foxi3 34
  • 78.39 (n)
chicken
(Gallus gallus)
Aves FOXI3 34
  • 65.84 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia foxi4.1 34
  • 61.17 (n)
zebrafish
(Danio rerio)
Actinopterygii foxi2 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11012 34
Species where no ortholog for FOXI3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXI3 Gene

ENSEMBL:
Gene Tree for FOXI3 (if available)
TreeFam:
Gene Tree for FOXI3 (if available)

Paralogs for FOXI3 Gene

(6) SIMAP similar genes for FOXI3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXI3: view

Variants for FOXI3 Gene

Sequence variations from dbSNP and Humsavar for FOXI3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1016858 -- 88,450,513(-) TTTTT(C/T)CCTAT intron-variant
rs1016859 -- 88,450,440(-) GAGGt(G/T)ttttt intron-variant
rs112079928 -- 88,450,513(+) ATAGG(-/G)AAAAA intron-variant
rs113132152 -- 88,447,846(+) TTGTG(-/T)TTTTT downstream-variant-500B
rs113453500 -- 88,454,074(+) TTAAT(G/T)GTCTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FOXI3 Gene

Variant ID Type Subtype PubMed ID
nsv582387 CNV gain 21841781
nsv582386 CNV loss 21841781
nsv582384 CNV loss 21841781
nsv582383 CNV gain 21841781
nsv470476 CNV gain 18288195
nsv458596 CNV gain 19166990
nsv1148611 CNV deletion 26484159
nsv1130752 CNV deletion 24896259
nsv1072005 CNV deletion 25765185
dgv6947n54 CNV gain 21841781
dgv61n16 CNV deletion 17901297
dgv1950n106 CNV deletion 24896259

Relevant External Links for FOXI3 Gene

Human Gene Mutation Database (HGMD)
FOXI3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXI3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for FOXI3 Gene

Disorders for FOXI3 Gene

Relevant External Links for FOXI3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXI3

No disorders were found for FOXI3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXI3 Gene

Publications for FOXI3 Gene

  1. A mutation in hairless dogs implicates FOXI3 in ectodermal development. (PMID: 18787161) Droegemueller C. … Leeb T. (Science 2008) 2 3 4 64
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64

Products for FOXI3 Gene

Sources for FOXI3 Gene

Content
Loading form....