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Aliases for FOXI3 Gene

Aliases for FOXI3 Gene

  • Forkhead Box I3 2 3

External Ids for FOXI3 Gene

Summaries for FOXI3 Gene

GeneCards Summary for FOXI3 Gene

FOXI3 (Forkhead Box I3) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for FOXI3 Gene

  • Possible transcriptional factor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXI3 Gene

Genomics for FOXI3 Gene

Genomic Location for FOXI3 Gene

Start:
88,446,787 bp from pter
End:
88,452,656 bp from pter
Size:
5,870 bases
Orientation:
Minus strand

Genomic View for FOXI3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXI3 Gene

Proteins for FOXI3 Gene

  • Protein details for FOXI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MTJ6-FOXI3_HUMAN
    Recommended name:
    Forkhead box protein I3
    Protein Accession:
    A8MTJ6
    Secondary Accessions:
    • B5RI09

    Protein attributes for FOXI3 Gene

    Size:
    420 amino acids
    Molecular mass:
    43326 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXI3 Gene

Proteomics data for FOXI3 Gene at MOPED

Post-translational modifications for FOXI3 Gene

No Post-translational modifications

Other Protein References for FOXI3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXI3 Gene

Domains for FOXI3 Gene

Protein Domains for FOXI3 Gene

UniProtKB/Swiss-Prot:

FOXI3_HUMAN
Domain:
  • Contains 1 fork-head DNA-binding domain.:
    • A8MTJ6
genes like me logo Genes that share domains with FOXI3: view

No data available for Gene Families for FOXI3 Gene

Function for FOXI3 Gene

Molecular function for FOXI3 Gene

UniProtKB/Swiss-Prot Function: Possible transcriptional factor.

Gene Ontology (GO) - Molecular Function for FOXI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXI3: view

Phenotypes for FOXI3 Gene

GenomeRNAi human phenotypes for FOXI3:
genes like me logo Genes that share phenotypes with FOXI3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FOXI3 Gene

Localization for FOXI3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXI3 Gene

Gene Ontology (GO) - Cellular Components for FOXI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with FOXI3: view

Pathways for FOXI3 Gene

SuperPathways for FOXI3 Gene

No Data Available

Interacting Proteins for FOXI3 Gene

Gene Ontology (GO) - Biological Process for FOXI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with FOXI3: view

No data available for Pathways by source for FOXI3 Gene

Transcripts for FOXI3 Gene

mRNA/cDNA for FOXI3 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXI3 Gene

Forkhead box I3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXI3 Gene

No ASD Table

Relevant External Links for FOXI3 Gene

GeneLoc Exon Structure for
FOXI3
ECgene alternative splicing isoforms for
FOXI3

Expression for FOXI3 Gene

mRNA expression in normal human tissues for FOXI3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXI3 Gene

This gene is overexpressed in Testis (21.8), Skin - Not Sun Exposed (Suprapubic) (9.2), Pituitary (6.2), and Skin - Sun Exposed (Lower leg) (5.7).

SOURCE GeneReport for Unigene cluster for FOXI3 Gene Hs.716722

genes like me logo Genes that share expressions with FOXI3: view

Orthologs for FOXI3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FOXI3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXI3 36
  • 98.56 (n)
  • 98.98 (a)
cow
(Bos Taurus)
Mammalia FOXI3 36
  • 85.71 (n)
  • 84.52 (a)
dog
(Canis familiaris)
Mammalia FOXI3 36
  • 83.97 (n)
  • 81.67 (a)
mouse
(Mus musculus)
Mammalia Foxi3 36
  • 79.55 (n)
  • 75.76 (a)
Foxi3 16
rat
(Rattus norvegicus)
Mammalia Foxi3 36
  • 78.39 (n)
  • 75.88 (a)
chicken
(Gallus gallus)
Aves FOXI3 36
  • 65.84 (n)
  • 59.57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia foxi4.1 36
  • 61.17 (n)
  • 62.17 (a)
zebrafish
(Danio rerio)
Actinopterygii foxi2 36
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11012 36
Species with no ortholog for FOXI3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXI3 Gene

ENSEMBL:
Gene Tree for FOXI3 (if available)
TreeFam:
Gene Tree for FOXI3 (if available)

Paralogs for FOXI3 Gene

Selected SIMAP similar genes for FOXI3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXI3: view

No data available for Paralogs for FOXI3 Gene

Variants for FOXI3 Gene

Sequence variations from dbSNP and Humsavar for FOXI3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs714148 -- 88,449,341(+) GCACA(C/G)AGTAA intron-variant
rs1016858 -- 88,450,513(-) TTTTT(C/T)CCTAT intron-variant
rs1016859 -- 88,450,440(-) GAGGt(G/T)ttttt intron-variant
rs3079282 -- 88,450,160(-) AGCCA(-/CC)GCGCC intron-variant
rs4972212 -- 88,448,871(+) TATTC(A/T)ATGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOXI3 Gene

Variant ID Type Subtype PubMed ID
dgv61n16 CNV Deletion 17901297
nsv458596 CNV Gain 19166990
nsv470476 CNV Gain 18288195

Relevant External Links for FOXI3 Gene

HapMap Linkage Disequilibrium report
FOXI3

Disorders for FOXI3 Gene

No disorders were found for FOXI3 Gene.

No data available for UniProtKB/Swiss-Prot for FOXI3 Gene

Publications for FOXI3 Gene

  1. A mutation in hairless dogs implicates FOXI3 in ectodermal development. (PMID: 18787161) Droegemueller C. … Leeb T. (Science 2008) 2 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for FOXI3 Gene

Sources for FOXI3 Gene

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