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Aliases for FOXI3 Gene

Aliases for FOXI3 Gene

  • Forkhead Box I3 2 3 5

External Ids for FOXI3 Gene

Previous GeneCards Identifiers for FOXI3 Gene

  • GC02M088520
  • GC02M088747
  • GC02M087669

Summaries for FOXI3 Gene

GeneCards Summary for FOXI3 Gene

FOXI3 (Forkhead Box I3) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is FOXE3.

UniProtKB/Swiss-Prot for FOXI3 Gene

  • Possible transcriptional factor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXI3 Gene

Genomics for FOXI3 Gene

Regulatory Elements for FOXI3 Gene

Enhancers for FOXI3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FOXI3 on UCSC Golden Path with GeneCards custom track

Genomic Location for FOXI3 Gene

88,446,787 bp from pter
88,452,656 bp from pter
5,870 bases
Minus strand

Genomic View for FOXI3 Gene

Genes around FOXI3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXI3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXI3 Gene

Proteins for FOXI3 Gene

  • Protein details for FOXI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Forkhead box protein I3
    Protein Accession:
    Secondary Accessions:
    • B5RI09

    Protein attributes for FOXI3 Gene

    420 amino acids
    Molecular mass:
    43326 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXI3 Gene

Proteomics data for FOXI3 Gene at MOPED

Post-translational modifications for FOXI3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXI3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXI3 Gene

Domains & Families for FOXI3 Gene

Protein Domains for FOXI3 Gene

Suggested Antigen Peptide Sequences for FOXI3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 fork-head DNA-binding domain.
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXI3: view

No data available for Gene Families for FOXI3 Gene

Function for FOXI3 Gene

Molecular function for FOXI3 Gene

UniProtKB/Swiss-Prot Function:
Possible transcriptional factor.

Gene Ontology (GO) - Molecular Function for FOXI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with FOXI3: view
genes like me logo Genes that share phenotypes with FOXI3: view

Animal Models for FOXI3 Gene

MGI Knock Outs for FOXI3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FOXI3 Gene

Localization for FOXI3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXI3 Gene

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for FOXI3 Gene

Pathways & Interactions for FOXI3 Gene

SuperPathways for FOXI3 Gene

No Data Available

Interacting Proteins for FOXI3 Gene

Gene Ontology (GO) - Biological Process for FOXI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with FOXI3: view

No data available for Pathways by source and SIGNOR curated interactions for FOXI3 Gene

Drugs & Compounds for FOXI3 Gene

No Compound Related Data Available

Transcripts for FOXI3 Gene

mRNA/cDNA for FOXI3 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXI3 Gene

Forkhead box I3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXI3 Gene

No ASD Table

Relevant External Links for FOXI3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FOXI3 Gene

mRNA expression in normal human tissues for FOXI3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXI3 Gene

This gene is overexpressed in Testis (x21.8), Skin - Not Sun Exposed (Suprapubic) (x9.2), Pituitary (x6.2), and Skin - Sun Exposed (Lower leg) (x5.7).

SOURCE GeneReport for Unigene cluster for FOXI3 Gene Hs.716722

genes like me logo Genes that share expression patterns with FOXI3: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FOXI3 Gene

Orthologs for FOXI3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FOXI3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FOXI3 35
  • 85.71 (n)
  • 84.52 (a)
(Canis familiaris)
Mammalia FOXI3 35
  • 83.97 (n)
  • 81.67 (a)
(Mus musculus)
Mammalia Foxi3 35
  • 79.55 (n)
  • 75.76 (a)
Foxi3 16
(Pan troglodytes)
Mammalia FOXI3 35
  • 98.56 (n)
  • 98.98 (a)
(Rattus norvegicus)
Mammalia Foxi3 35
  • 78.39 (n)
  • 75.88 (a)
(Gallus gallus)
Aves FOXI3 35
  • 65.84 (n)
  • 59.57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia foxi4.1 35
  • 61.17 (n)
  • 62.17 (a)
(Danio rerio)
Actinopterygii foxi2 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11012 35
Species with no ortholog for FOXI3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXI3 Gene

Gene Tree for FOXI3 (if available)
Gene Tree for FOXI3 (if available)

Paralogs for FOXI3 Gene

(6) SIMAP similar genes for FOXI3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXI3: view

Variants for FOXI3 Gene

Sequence variations from dbSNP and Humsavar for FOXI3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs714148 -- 88,449,341(+) GCACA(C/G)AGTAA intron-variant
rs1016858 -- 88,450,513(-) TTTTT(C/T)CCTAT intron-variant
rs1016859 -- 88,450,440(-) GAGGt(G/T)ttttt intron-variant
rs3079282 -- 88,450,160(-) AGCCA(-/CC/CCC)GCGCC intron-variant
rs4972212 -- 88,448,871(+) TATTC(A/T)ATGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOXI3 Gene

Variant ID Type Subtype PubMed ID
dgv61n16 CNV Deletion 17901297
nsv458596 CNV Gain 19166990
nsv470476 CNV Gain 18288195

Relevant External Links for FOXI3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for FOXI3 Gene

Disorders for FOXI3 Gene

Relevant External Links for FOXI3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FOXI3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXI3 Gene

Publications for FOXI3 Gene

  1. A mutation in hairless dogs implicates FOXI3 in ectodermal development. (PMID: 18787161) Droegemueller C. … Leeb T. (Science 2008) 2 3 4 67
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3

Products for FOXI3 Gene

Sources for FOXI3 Gene