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Aliases for FOXI2 Gene

Aliases for FOXI2 Gene

  • Forkhead Box I2 2 3 5

External Ids for FOXI2 Gene

Previous GeneCards Identifiers for FOXI2 Gene

  • GC10P129427
  • GC10P129535
  • GC10P123109

Summaries for FOXI2 Gene

GeneCards Summary for FOXI2 Gene

FOXI2 (Forkhead Box I2) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXA2.

UniProtKB/Swiss-Prot for FOXI2 Gene

  • Possible transcriptional activator.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXI2 Gene

Genomics for FOXI2 Gene

Regulatory Elements for FOXI2 Gene

Promoters for FOXI2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FOXI2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FOXI2 Gene

Chromosome:
10
Start:
127,737,235 bp from pter
End:
127,741,186 bp from pter
Size:
3,952 bases
Orientation:
Plus strand

Genomic View for FOXI2 Gene

Genes around FOXI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXI2 Gene

Proteins for FOXI2 Gene

  • Protein details for FOXI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZQN5-FOXI2_HUMAN
    Recommended name:
    Forkhead box protein I2
    Protein Accession:
    Q6ZQN5

    Protein attributes for FOXI2 Gene

    Size:
    318 amino acids
    Molecular mass:
    32979 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXI2 Gene

Proteomics data for FOXI2 Gene at MOPED

Post-translational modifications for FOXI2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXI2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXI2 Gene

Domains & Families for FOXI2 Gene

Gene Families for FOXI2 Gene

Protein Domains for FOXI2 Gene

Suggested Antigen Peptide Sequences for FOXI2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZQN5

UniProtKB/Swiss-Prot:

FOXI2_HUMAN :
  • Contains 1 fork-head DNA-binding domain.
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXI2: view

Function for FOXI2 Gene

Molecular function for FOXI2 Gene

UniProtKB/Swiss-Prot Function:
Possible transcriptional activator.

Gene Ontology (GO) - Molecular Function for FOXI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with FOXI2: view
genes like me logo Genes that share phenotypes with FOXI2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FOXI2 Gene

Localization for FOXI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXI2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXI2 Gene COMPARTMENTS Subcellular localization image for FOXI2 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for FOXI2 Gene

Pathways & Interactions for FOXI2 Gene

SuperPathways for FOXI2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with FOXI2: view

No data available for Pathways by source and SIGNOR curated interactions for FOXI2 Gene

Drugs & Compounds for FOXI2 Gene

No Compound Related Data Available

Transcripts for FOXI2 Gene

mRNA/cDNA for FOXI2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXI2 Gene

Forkhead box I2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXI2 Gene

No ASD Table

Relevant External Links for FOXI2 Gene

GeneLoc Exon Structure for
FOXI2
ECgene alternative splicing isoforms for
FOXI2

Expression for FOXI2 Gene

mRNA expression in normal human tissues for FOXI2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXI2 Gene

This gene is overexpressed in Esophagus - Mucosa (x8.9), Kidney - Cortex (x8.6), and Cervix - Endocervix (x6.6).

Protein differential expression in normal tissues from HIPED for FOXI2 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FOXI2 Gene



SOURCE GeneReport for Unigene cluster for FOXI2 Gene Hs.449674

genes like me logo Genes that share expression patterns with FOXI2: view

Protein tissue co-expression partners for FOXI2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FOXI2 Gene

Orthologs for FOXI2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXI2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXI2 36
  • 98 (a)
OneToOne
FOXI2 35
  • 98.22 (n)
  • 97.8 (a)
cow
(Bos Taurus)
Mammalia FOXI2 35
  • 84.08 (n)
  • 78.53 (a)
FOXI2 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXI2 36
  • 70 (a)
OneToOne
FOXI2 35
  • 80.48 (n)
  • 73.03 (a)
mouse
(Mus musculus)
Mammalia Foxi2 16
Foxi2 36
  • 70 (a)
OneToOne
Foxi2 35
  • 77.49 (n)
  • 73.63 (a)
oppossum
(Monodelphis domestica)
Mammalia FOXI2 36
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxi2 35
  • 76.53 (n)
  • 72.35 (a)
chicken
(Gallus gallus)
Aves FOXI2 36
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXI2 36
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii foxi1 36
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta croc 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
-- 36
  • 28 (a)
OneToMany
Species with no ortholog for FOXI2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXI2 Gene

ENSEMBL:
Gene Tree for FOXI2 (if available)
TreeFam:
Gene Tree for FOXI2 (if available)

Paralogs for FOXI2 Gene

(10) SIMAP similar genes for FOXI2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FOXI2: view

Variants for FOXI2 Gene

Sequence variations from dbSNP and Humsavar for FOXI2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs3890093 -- 127,739,803(+) CACAC(C/T)CACAC utr-variant-3-prime
rs4440944 -- 127,739,875(+) CACAC(C/T)CACAC utr-variant-3-prime
rs11018291 -- 127,739,983(+) cacac(C/T)cacac utr-variant-3-prime
rs11018296 -- 127,740,030(+) CACAC(A/C/T)CACAC utr-variant-3-prime
rs11018297 -- 127,740,037(+) acact(C/G)acacT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FOXI2 Gene

Variant ID Type Subtype PubMed ID
esv24992 CNV Gain 19812545
esv2743284 CNV Deletion 23290073

Variation tolerance for FOXI2 Gene

Residual Variation Intolerance Score: 78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.63; 45.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXI2 Gene

HapMap Linkage Disequilibrium report
FOXI2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXI2 Gene

Disorders for FOXI2 Gene

Relevant External Links for FOXI2

Genetic Association Database (GAD)
FOXI2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXI2

No disorders were found for FOXI2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXI2 Gene

Publications for FOXI2 Gene

  1. Cloning and analysis of the murine Foxi2 transcription factor. (PMID: 16289364) Wijchers P.J. … Smidt M.P. (Biochim. Biophys. Acta 2005) 3
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FOXI2 Gene

Sources for FOXI2 Gene

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