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Aliases for FOXI2 Gene

Aliases for FOXI2 Gene

  • Forkhead Box I2 2 3

External Ids for FOXI2 Gene

Previous GeneCards Identifiers for FOXI2 Gene

  • GC10P129427
  • GC10P129535
  • GC10P123109

Summaries for FOXI2 Gene

GeneCards Summary for FOXI2 Gene

FOXI2 (Forkhead Box I2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding and double-stranded DNA binding. An important paralog of this gene is FOXE3.

UniProtKB/Swiss-Prot for FOXI2 Gene

  • Possible transcriptional activator.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXI2 Gene

Genomics for FOXI2 Gene

Regulatory Elements for FOXI2 Gene

Genomic Location for FOXI2 Gene

Start:
127,737,235 bp from pter
End:
127,741,186 bp from pter
Size:
3,952 bases
Orientation:
Plus strand

Genomic View for FOXI2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXI2 Gene

Proteins for FOXI2 Gene

  • Protein details for FOXI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZQN5-FOXI2_HUMAN
    Recommended name:
    Forkhead box protein I2
    Protein Accession:
    Q6ZQN5
    Secondary Accessions:

    Protein attributes for FOXI2 Gene

    Size:
    318 amino acids
    Molecular mass:
    32979 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXI2 Gene

Proteomics data for FOXI2 Gene at MOPED

Post-translational modifications for FOXI2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXI2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXI2 Gene

Domains for FOXI2 Gene

Gene Families for FOXI2 Gene

HGNC:
  • FOX :Forkhead boxes

Protein Domains for FOXI2 Gene

Suggested Antigen Peptide Sequences for FOXI2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZQN5

UniProtKB/Swiss-Prot:

FOXI2_HUMAN :
  • Q6ZQN5
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXI2: view

Function for FOXI2 Gene

Molecular function for FOXI2 Gene

UniProtKB/Swiss-Prot Function: Possible transcriptional activator.

Gene Ontology (GO) - Molecular Function for FOXI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXI2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FOXI2 Gene

Localization for FOXI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXI2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXI2 Gene COMPARTMENTS Subcellular localization image for FOXI2 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for FOXI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with FOXI2: view

Pathways for FOXI2 Gene

SuperPathways for FOXI2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0009653 anatomical structure morphogenesis IBA --
genes like me logo Genes that share ontologies with FOXI2: view

No data available for Pathways by source for FOXI2 Gene

Transcripts for FOXI2 Gene

mRNA/cDNA for FOXI2 Gene

(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXI2 Gene

Forkhead box I2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXI2 Gene

No ASD Table

Relevant External Links for FOXI2 Gene

GeneLoc Exon Structure for
FOXI2
ECgene alternative splicing isoforms for
FOXI2

Expression for FOXI2 Gene

mRNA expression in normal human tissues for FOXI2 Gene

mRNA differential expression in normal tissues according to GTEx for FOXI2 Gene

This gene is overexpressed in Esophagus - Mucosa (8.9), Kidney - Cortex (8.6), and Cervix - Endocervix (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FOXI2 Gene

SOURCE GeneReport for Unigene cluster for FOXI2 Gene Hs.449674

genes like me logo Genes that share expressions with FOXI2: view

No data available for mRNA Expression by UniProt/SwissProt for FOXI2 Gene

Orthologs for FOXI2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXI2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXI2 35
  • 98.22 (n)
  • 97.8 (a)
FOXI2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FOXI2 35
  • 84.08 (n)
  • 78.53 (a)
FOXI2 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXI2 35
  • 80.48 (n)
  • 73.03 (a)
FOXI2 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxi2 35
  • 77.49 (n)
  • 73.63 (a)
Foxi2 16
Foxi2 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FOXI2 36
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxi2 35
  • 76.53 (n)
  • 72.35 (a)
chicken
(Gallus gallus)
Aves FOXI2 36
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXI2 36
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii foxi1 36
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta croc 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
-- 36
  • 28 (a)
OneToMany
Species with no ortholog for FOXI2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXI2 Gene

ENSEMBL:
Gene Tree for FOXI2 (if available)
TreeFam:
Gene Tree for FOXI2 (if available)

Paralogs for FOXI2 Gene

Selected SIMAP similar genes for FOXI2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FOXI2: view

Variants for FOXI2 Gene

Sequence variations from dbSNP and Humsavar for FOXI2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1887005 -- 127,739,827(-) GTGTG(A/G)GTGTG utr-variant-3-prime
rs3890093 -- 127,739,803(+) CACAC(C/T)CACAC utr-variant-3-prime
rs4440944 -- 127,739,875(+) CACAC(C/T)CACAC utr-variant-3-prime
rs4992328 -- 127,740,209(+) CACAC(C/T)CACAC utr-variant-3-prime
rs5788867 -- 127,739,920(+) CCACA(-/C)CCACA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FOXI2 Gene

Variant ID Type Subtype PubMed ID
esv24992 CNV Gain 19812545
esv2743284 CNV Deletion 23290073

Relevant External Links for FOXI2 Gene

HapMap Linkage Disequilibrium report
FOXI2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXI2 Gene

Disorders for FOXI2 Gene

Relevant External Links for FOXI2

Genetic Association Database (GAD)
FOXI2
genes like me logo Genes that share disorders with FOXI2: view

No data available for UniProtKB/Swiss-Prot for FOXI2 Gene

Publications for FOXI2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Cloning and analysis of the murine Foxi2 transcription factor. (PMID: 16289364) Wijchers P.J. … Smidt M.P. (Biochim. Biophys. Acta 2005) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 4

Products for FOXI2 Gene

Sources for FOXI2 Gene

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