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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FOXI2 Gene

protein-coding GIFtS: 36
GCID: GC10P129535

forkhead box I2

Search for FOXI2
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Forkhead Box I2¹ ²
FLJ46831¹
Forkhead Box Protein I2²
Homolog Of Mouse Foxi2²

External Ids:	HGNC: 32448¹	Entrez Gene: 399823²	Ensembl: ENSG00000186766⁷	UniProtKB: Q6ZQN5³

Export aliases for FOXI2 gene to outside databases

Previous GC identifers: GC10P129427 GC10P123109

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: FOXI2_HUMAN, Q6ZQN5

Function: Possible transcriptional activator (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_008818.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FOXI2 gene promoter:
STAT5B STAT1 STAT4 STAT1beta STAT5A NF-kappaB STAT1alpha STAT2 STAT3 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FOXI2 promoter sequence

Search SABiosciences Chromatin IP Primers for FOXI2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXI2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.2 Ensembl cytogenetic band: 10q26.2 HGNC cytogenetic band: 10q26.2

FOXI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXI2 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P129535: view genomic region (about GC identifiers)

Start:	129,535,499 bp from pter	End:	129,539,450 bp from pter
Size:	3,952 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FOXI2_HUMAN, Q6ZQN5 (See protein sequence)

Recommended Name: Forkhead box protein I2

Size: 318 amino acids; 32979 Da

Subcellular location: Nucleus (Probable)

Explore the universe of human proteins at neXtProt for FOXI2: NX_Q6ZQN5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6ZQN5

FOXI2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_997309.2

ENSEMBL proteins:

ENSP00000373572

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005667	transcription factor complex	IBA	--

FOXI2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FOXI2 for domains About GeneDecksing

3 InterPro domains/families:

IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

IPR018122 TF_fork_head_CS

IPR001766 TF_fork_head

Graphical View of Domain Structure for InterPro Entry Q6ZQN5

ProtoNet protein and cluster: Q6ZQN5

UniProtKB/Swiss-Prot: FOXI2_HUMAN, Q6ZQN5

Similarity: Contains 1 fork-head DNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FOXI2_HUMAN, Q6ZQN5

Function: Possible transcriptional activator (By similarity)

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Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003690	double-stranded DNA binding	IBA	--
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	IBA	--
GO:0008134	transcription factor binding	IBA	--
GO:0008301	DNA binding, bending	IBA	--
GO:0043565	sequence-specific DNA binding	IEA	--

FOXI2 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FOXI2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for FOXI2 (ENSP00000373572⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NF2	ENSP00000344666⁴	STRING: ENSP00000344666

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007389	pattern specification process	IBA	--
GO:0009957	epidermal cell fate specification	IBA	--
GO:0043049	otic placode formation	IBA	--
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity	IBA	--

FOXI2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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Search CenterWatch for drugs/clinical trials and news about FOXI2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for FOXI2 gene:

NM_207426.2

Unigene Cluster for FOXI2:

Forkhead box I2

Hs.449674 [show with all ESTs]

Unigene Representative Sequence: NM_207426

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000388920(uc009yas.2)

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Additional cDNA sequence:

AK128865.1 BC137296.1 BC137297.1

1 DOTS entry:

DT.86848635

5 AceView cDNA sequences:

AW611868 AW299481 AK128865 NM_207426 AA302650

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FOXI2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

FOXI2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Interstitial Stroma

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FOXI2 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.449674

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FOXI2 gene from 2/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
zebrafish (Danio rerio)	Actinopterygii	foxi2⁶ foxi1⁶	forkhead box i1	39(a) 36(a)	possible ortholog 1 ↔ 1	13(13439565-13442146) 16(2302274-2304041)
worm (Caenorhabditis elegans)	Secernentea	fkh-6⁶	ForKHead transcription factor family member (fkh-6...	21(a)	1 → many	II(4379886-4383290)

ENSEMBL Gene Tree for FOXI2 (if available)
TreeFam Gene Tree for FOXI2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FOXI2 gene

FOXF1² FOXA2² FOXD4L1² FOXF2² FOXC2² FOXB1² FOXE3² FOXC1²

FOXD4L2² FOXQ1² FOXD4L3² FOXA3² FOXD1² FOXD3² FOXD4L5² FOXD4L4²

FOXE1² FOXL1² FOXA1² FOXI1² FOXB2² FOXD4L6² FOXS1² FOXD2²

FOXL2² FOXD4²

9 SIMAP similar genes for FOXI2 using alignment to 2 protein entries: FOXI2_HUMAN (see all proteins):

FOXS1 FOXI1 FOXC1 FOXB1 FOXD1 FOXL1

FOXI3 FOXA1 FOXL2

FOXI2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs144354907^1,2		--	129537443(+)	`CCAGGA/CGACCT`	1	--	ut3¹		0	--	--	--	--
rs1887006^1,2	C,A,H,	--	129537454(-)	`GGAGGC/TTCCGA`	1	--	ut3¹		12		NA WA CSA EA	374
rs7897930^1,2	C,	--	129537474(+)	`CTCTAA/TGTCCA`	1	--	ut3¹		0	--	--	--	--
rs112190337^1,2		--	129537483(+)	`CAGCCG/ACCCTG`	1	--	ut3¹		1		CSA	2
rs142266253^1,2		--	129537533(+)	`GGGGCA/GGCGGG`	1	--	ut3¹		0	--	--	--	--
rs146383820^1,2		--	129537699(+)	`TGCTTC/TAGGGA`	1	--	ut3¹		0	--	--	--	--
rs114288088^1,2	C,F,	--	129537756(+)	`GGCTCC/AAGGTG`	1	--	ut3¹		1		WA	118
rs72843154^1,2	C,	--	129537821(+)	`AGGAAG/AGNNNN`	1	--	ut3¹		4		CSA WA NA	241
rs72843155^1,2	C,	--	129537930(+)	`TCCTTG/CATGAC`	1	--	ut3¹		3		CSA WA NA	240
rs183802124^1,2		--	129538022(+)	`AGGGTC/GCAGGT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FOXI2 (129535499 - 129539450 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FOXI2
1 CNV: 71138

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FOXI2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FOXI2)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and analysis of the murine Foxi2 transcription factor. (PubMed id 16289364)¹ Wijchers P.J....Smidt M.P. (2005)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)² Deloukas P.... Rogers J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 399823	HGNC: 32448	AceView: FLJ46831	Ensembl:ENSG00000186766	euGenes: HUgn399823
ECgene: FOXI2	H-InvDB: FOXI2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FOXI2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FOXI2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FOXI2 gene:
Search GeneIP for patents involving FOXI2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes FOXI2 gene at Home site.

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FOXI2 Gene

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Export list of displayed genes

FOXI2 Gene

forkhead box I2

Aliasesfor FOXI2 gene

Summariesfor FOXI2 gene

Genomic Viewsfor FOXI2 gene

Proteinsfor FOXI2 gene

Protein Domains /Familiesfor FOXI2 gene

Functionfor FOXI2 gene

Pathways & Interactionsfor FOXI2 gene

Drugs & Compoundsfor FOXI2 gene

Transcriptsfor FOXI2 gene

Expression for FOXI2 gene

Orthologsfor FOXI2 gene

Paralogsfor FOXI2 gene

Genomic Variantsfor FOXI2 gene

Disorders / Diseasesfor FOXI2 gene

Publicationsfor FOXI2 gene

External Searches for FOXI2 gene

Genome Databases showing FOXI2 gene

Other Databases showing FOXI2 gene

Specialized Databases showing FOXI2 gene

Intellectual Propertyfor FOXI2 gene

Productsfor FOXI2 gene

View Random Gene

Aliases
for FOXI2 gene

Summaries
for FOXI2 gene

Genomic Views
for FOXI2 gene

Proteins
for FOXI2 gene

Protein Domains /
Families
for FOXI2 gene

Function
for FOXI2 gene

Pathways & Interactions
for FOXI2 gene

Drugs & Compounds
for FOXI2 gene

Transcripts
for FOXI2 gene

Expression
for FOXI2 gene

Orthologs
for FOXI2 gene

Paralogs
for FOXI2 gene

Genomic Variants
for FOXI2 gene

Disorders / Diseases
for FOXI2 gene

Publications
for FOXI2 gene

Intellectual Property
for FOXI2 gene

Products
for FOXI2 gene