Aliases for FOXH1 Gene
External Ids for FOXH1 Gene
Previous GeneCards Identifiers for FOXH1 Gene
FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT. [provided by RefSeq, Jul 2008]
GeneCards Summary for FOXH1 Gene
FOXH1 (Forkhead Box H1) is a Protein Coding gene. Diseases associated with FOXH1 include Lobar Holoprosencephaly and Septopreoptic Holoprosencephaly. Among its related pathways are Regulation of nuclear SMAD2/3 signaling and DREAM Repression and Dynorphin Expression. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein domain specific binding. An important paralog of this gene is FOXK2.
UniProtKB/Swiss-Prot for FOXH1 Gene
Transcriptional activator. Recognizes and binds to the DNA sequence 5-TGT[GT][GT]ATT-3. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).