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FOXH1 Gene

protein-coding   GIFtS: 59
GCID: GC08M145698

Forkhead Box H1

  See FOXH1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Forkhead Box H11 2     Forkhead Box Protein H12
FAST12 3 5     TGF-Beta/Activin Signal Transducer2
Forkhead Activin Signal Transducer 22 3     FAST23
hFAST-12 3     Fast-13
FAST-12     Fast-23
fast-22     Forkhead Activin Signal Transducer 13
Forkhead Activin Signal Transducer-12     

External Ids:    HGNC: 38141   Entrez Gene: 89282   Ensembl: ENSG000001609737   OMIM: 6036215   UniProtKB: O755933   

Export aliases for FOXH1 gene to outside databases

Previous GC identifers: GC08M143400 GC08M145737 GC08M145305 GC08M145704 GC08M145670 GC08M145669 GC08M140814


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FOXH1 Gene:
FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and
activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT. (provided by RefSeq, Jul 2008)

GeneCards Summary for FOXH1 Gene:
FOXH1 (forkhead box H1) is a protein-coding gene. Diseases associated with FOXH1 include foxh1-related holoprosencephaly, and ventricular septal defect. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOXF1.

UniProtKB/Swiss-Prot: FOXH1_HUMAN, O75593
Function: Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for
induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active
complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response
element)

Gene Wiki entry for FOXH1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the FOXH1 gene promoter:
         Sp1   p53   Nkx2-5   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FOXH1 promoter sequence
   Search Chromatin IP Primers for FOXH1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FOXH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24

FOXH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXH1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M145698:  view genomic region     (about GC identifiers)

Start:
145,698,795 bp from pter      End:
145,701,718 bp from pter
Size:
2,924 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FOXH1_HUMAN, O75593 (See protein sequence)
Recommended Name: Forkhead box protein H1  
Size: 365 amino acids; 39257 Da
Subunit: Interacts with the MH2 domains of SMAD2 and SMAD3
Secondary accessions: D3DWM4

Explore the universe of human proteins at neXtProt for FOXH1: NX_O75593

Explore proteomics data for FOXH1 at MOPED


See FOXH1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_003914.1  
ENSEMBL proteins: 
 ENSP00000366534  
Reactome Protein details: O75593

FOXH1 Human Recombinant Protein Products:

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Search eBioscience for Proteins for FOXH1 

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
FOX: Forkhead boxes

3 InterPro protein domains:
 IPR011991 WHTH_DNA-bd_dom
 IPR018122 TF_fork_head_CS
 IPR001766 TF_fork_head

Graphical View of Domain Structure for InterPro Entry O75593

ProtoNet protein and cluster: O75593

UniProtKB/Swiss-Prot: FOXH1_HUMAN, O75593
Domain: The FM region is required for binding SMAD2/SMAD4 complexes. FM2 is more effective than FM1 and only
interacts with phosphorylated SMAD2 that is in an activated SMAD complex (By similarity)
Similarity: Contains 1 fork-head DNA-binding domain


Find genes that share domains with FOXH1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: FOXH1_HUMAN, O75593
Function: Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for
induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active
complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response
element)

     Genatlas biochemistry entry for FOXH1:
forkhead box H1,TGF-beta/activin signal transducer,Xenopus homolog,ubiquitously expressed,also expressed in
several cancer cell lines binding SMAD2 (MADH2) and activating response element (ARE),may be in injunction with
SMAD4 (MADH4)

     Gene Ontology (GO): Selected molecular function terms (see all 17):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001104RNA polymerase II transcription cofactor activity IEA--
GO:0001190RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription IEA--
GO:0001205RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
GO:0003677contributes to DNA binding IDA9389648
GO:0003690double-stranded DNA binding IBA--
     
Find genes that share ontologies with FOXH1           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for FOXH1:
 Elongated cells 

     13 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Foxh1):
 cardiovascular system  craniofacial  digestive/alimentary  embryogenesis  growth/size/body 
 hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  muscle 
 nervous system  renal/urinary system  respiratory system 

Find genes that share phenotypes with FOXH1           About GenesLikeMe

Animal Models:
     MGI mouse knock-outs for FOXH1: Foxh1tm1Jlw Foxh1tm1.1Hmd

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FOXH1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FOXH1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FOXH1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FOXH1

Transcription Factor Targeting: 
Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                      Consensus sequence:  NNTGTGGATTSS 

miRNA
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7 qRT-PCR Assays for microRNAs that regulate FOXH1:
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXH1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXH1
Addgene plasmids for FOXH1 

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXH1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
FOXH1_HUMAN, O75593: Nucleus
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol2

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA16120611
GO:0005654nucleoplasm TAS--
GO:0005667transcription factor complex IDA17438144
GO:0032444activin responsive factor complex IDA9389648

Find genes that share ontologies with FOXH1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for FOXH1 About   (see all 13)  
See pathways by source

SuperPathContained pathways About
1Signaling by NODAL
Signaling by NODAL0.39
Signaling by Activin0.39
2L1CAM interactions
Developmental Biology0.63
3TGF-Beta Pathway
TGF-Beta Pathway0.60
4Signaling by GPCR
Signal Transduction0.58
5DREAM Repression and Dynorphin Expression
BMP Pathway0.44


Find genes that share SuperPaths with FOXH1           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 R&D Systems Pathway for FOXH1
    TGF-beta Signaling Pathways

3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FOXH1
    SMAD Signaling Network
BMP Pathway
TGF-Beta Pathway

2 GeneGo (Thomson Reuters) Pathways for FOXH1
    Signal transduction Activin A signaling regulation
Development TGF-beta receptor signaling

4 BioSystems Pathways for FOXH1
    Heart Development
TGF Beta Signaling Pathway
TGF-beta Receptor Signaling Pathway
Regulation of nuclear SMAD2/3 signaling

2 Reactome Pathways for FOXH1
    Signaling by Activin
Signaling by NODAL


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FOXH1
Interactions:

    GeneGlobe Interaction Network for FOXH1

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

Selected Interacting proteins for FOXH1 (O755931, 2, 3 ENSP000003665344) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
InteractantInteraction Details
GeneCardExternal ID(s)
PIK3R1P279862, 3, ENSP000002743354MINT-8111991 I2D: score=3 STRING: ENSP00000274335
NCK1P163331, 3, ENSP000002889864EBI-1759806,EBI-389883 I2D: score=2 STRING: ENSP00000288986
SMAD2Q157963, ENSP000002621604I2D: score=5 STRING: ENSP00000262160
SMAD3P840223, ENSP000003329734I2D: score=5 STRING: ENSP00000332973
GSCP569153, ENSP000002385584I2D: score=1 STRING: ENSP00000238558
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Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000122negative regulation of transcription from RNA polymerase II promoter IBA--
GO:0001568blood vessel development IBA--
GO:0001947heart looping IBA--
GO:0003139secondary heart field specification IEA--
GO:0003146NOT heart jogging IBA--

Find genes that share ontologies with FOXH1           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for FOXH1



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for FOXH1 gene: 
NM_003923.2  

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000377317(uc003zdc.3) ENST00000525197
miRNA
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7 qRT-PCR Assays for microRNAs that regulate FOXH1:
hsa-miR-18a hsa-miR-361-3p hsa-miR-3134 hsa-miR-1193 hsa-miR-18b hsa-miR-452 hsa-miR-4287
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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  QuantiTect SYBR Green Assays in human, mouse, rat FOXH1
  QuantiFast Probe-based Assays in human, mouse, rat FOXH1

24 AceView cDNA sequences:

AI636647 BC051376 AA548116 BC065377 AI632666 AI699939 AW235176 NM_003923 
CD048780 AF076292 AW451014 BE550635 AI631625 AI651640 AI916797 BE504812 
BE829294 BU855499 H14209 BF057145 BU859593 AI917314 AA218611 BF987037 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for FOXH1    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1:                                    
SP2:              -                     


ECgene alternative splicing isoforms for FOXH1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FOXH1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTCCTGGTGG
FOXH1 Expression
About this image


FOXH1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 5) fully expand
 
 Heart (Cardiovascular System)    fully expand to see all 6 entries
         Cardiomyocytes Outflow Tract
 
 Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
         Inner Cell Mass Cells Inner Cell Mass
         C2a
 
 Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
         Epiblast Cells Epiblast
         Epiblast Stem Cell line 5
 
 Hypoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
         Early Distal Visceral Endoderm Cells Visceral Endoderm
 
 Yolk Sac (Extraembryonic Tissues)
         Early Distal Visceral Endoderm Cells Visceral Endoderm
FOXH1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

FOXH1 Protein Expression

UniProtKB/Swiss-Prot: FOXH1_HUMAN, O75593
Tissue specificity: Ubiquitous

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXH1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for FOXH1 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Foxh11 , 5 forkhead box H11, 5 80.37(n)1
77.53(a)1
  15 (36.24 cM)5
141061  NM_007989.41  NP_032015.11 
 766683075 
lizard
(Anolis carolinensis)
Reptilia FOXH16
forkhead box H1
36(a)
1 ↔ 1
GL343750.1(234845-237885)
African clawed frog
(Xenopus laevis)
Amphibia LOC3980702 forkhead activin signal transducer 1 73.05(n)    U70980.1 
zebrafish
(Danio rerio)
Actinopterygii foxh12 forkhead box H1 71.62(n)   57930  AF263000.1 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FHL16
Regulator of ribosomal protein transcription; has ...
8(a)
1 → many
XVI(733623-736433) YPR104C


ENSEMBL Gene Tree for FOXH1 (if available)
TreeFam Gene Tree for FOXH1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for FOXH1 gene
FOXF12  FOXQ12  FOXN32  FOXJ12  FOXF22  FOXK12  FOXN42  FOXR12  
FOXK22  FOXN12  FOXJ32  FOXG12  FOXJ22  FOXN22  FOXR22  

Find genes that share paralogs with FOXH1           About GenesLikeMe


2 Pseudogenes.org Pseudogenes for FOXH1
PGOHUM00000243244 PGOHUM00000236348


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FOXH1 (see all 169)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1120282421,2,,4
C,FColorectal cancer4 --145973193(+) GGCGGT/AGTTCT 2 /T /S mis13Minor allele frequency- A:0.03CSA WA NA 3290
rs1448307401,2,,4
C,FColorectal cancer4 --145973228(+) TCAGGC/GTCACG 2 T S mis11Minor allele frequency- G:0.00NA 3712
rs26206681,2
C--145702694(-) cagagC/Tcagac 1 -- us2k10--------
rs1455011711,2
F--145971491(+) CTTCCC/TTCAGC 1 -- ds50011Minor allele frequency- T:0.00NA 3280
rs1429682781,2
C,F--145971514(+) CTCACC/TGGGAC 1 -- ds50011Minor allele frequency- T:0.00NA 3276
rs2010747861,2
C--145971605(+) CAGAGA/GGCCTG 1 -- ds50010--------
rs2018574331,2
C--145971612(+) CCTGCC/TCCTCT 1 -- ds50010--------
rs2001233861,2
--145971640(+) CTGCCC/TATGGG 1 -- ds50010--------
rs1839464981,2
--145971756(+) CCAGAC/GTCACC 1 -- ds50010--------
rs1888878951,2
--145971768(+) CTCCAC/TCTCCG 1 -- ds50010--------

HapMap Linkage Disequilibrium report for FOXH1 (145698795 - 145701718 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for FOXH1 (see all 25):    About this table    
Variant IDTypeSubtypePubMed ID
dgv907n27CNV Loss19166990
dgv7966n71CNV Loss21882294
dgv7977n71CNV Loss21882294
dgv7976n71CNV Loss21882294
nsv891841CNV Loss21882294
dgv7978n71CNV Loss21882294
dgv7980n71CNV Loss21882294
nsv891846CNV Loss21882294
nsv891817CNV Loss21882294
nsv891807CNV Loss21882294

Human Gene Mutation Database (HGMD): FOXH1
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing FOXH1
DNA2.0 Custom Variant and Variant Library Synthesis for FOXH1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 603621    OMIM disorders: --

8 diseases for FOXH1:    
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foxh1-related holoprosencephaly    ventricular septal defect    septopreoptic holoprosencephaly    midline interhemispheric variant of holoprosencephaly
alobar holoprosencephaly    single median maxillary central incisor    semilobar holoprosencephaly    lobar holoprosencephaly

1 disease from the University of Copenhagen DISEASES database for FOXH1:
Angioedema

Find genes that share disorders with FOXH1           About GenesLikeMe

Genetic Association Database (GAD): FOXH1
Human Genome Epidemiology (HuGE) Navigator: FOXH1 (2 documents)

Export disorders for FOXH1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FOXH1 gene, integrated from 10 sources (see all 48):
(articles sorted by number of sources associating them with FOXH1)
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  1. Characterization of human FAST-1, a TGF beta and activin signal transducer. (PubMed id 9702198)1, 2, 3, 9 Zhou S.... Vogelstein B. (Mol. Cell 1998)
  2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
  3. Forkhead box H1 (FOXH1) sequence variants in ventricular septal defect. (PubMed id 19525021)1, 4 Wang B....Ma X. (Int. J. Cardiol. 2010)
  4. Expression of the FAST-1 transcription factor in coronary artery transplant vasculopathy and activated vascular smooth muscle cells. (PubMed id 15737749)1, 9 Kelemen S.F....Autieri M.V. (J. Heart Lung Transplant. 2005)
  5. BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners. (PubMed id 10938097)1, 9 Dou C....Lai E. (Mol. Cell. Biol. 2000)
  6. Selective inhibition of TGF-beta responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP. (PubMed id 15750622)1, 9 Cui Q....Hoffmann F.M. (Oncogene 2005)
  7. ELAC2, a putative prostate cancer susceptibility gene product, potentiates TGF-beta/Smad-induced growth arrest of prostate cells. (PubMed id 16636667)1, 9 Noda D....Kato M. (Oncogene 2006)
  8. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
  9. HEB and E2A function as SMAD/FOXH1 cofactors. (PubMed id 21828274)1 Yoon S.J....Baker J.C. (amp 2011)
  10. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8928 HGNC: 3814 AceView: FOXH1 Ensembl:ENSG00000160973 euGenes: HUgn8928
ECgene: FOXH1 H-InvDB: FOXH1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FOXH1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for FOXH1 gene:
Search GeneIP for patents involving FOXH1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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