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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FOXH1 Gene

protein-coding GIFtS: 61
GCID: GC08M145669

forkhead box H1

Explore 7 diseases affiliated with
FOXH1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Forkhead Box H1¹ ²		Forkhead Box Protein H1²
FAST1¹ ² ³ ⁵		TGF-Beta/Activin Signal Transducer²
Forkhead Activin Signal Transducer 2² ³		FAST2³
HFAST-1¹		Fast-1³
FAST-1²		Fast-2³
Fast-2³		Forkhead Activin Signal Transducer 1³
Forkhead Activin Signal Transducer-1²

External Ids:	HGNC: 3814¹	Entrez Gene: 8928²	Ensembl: ENSG00000160973⁷	OMIM: 603621⁵	UniProtKB: O75593³

Export aliases for FOXH1 gene to outside databases

Previous GC identifers: GC08M143400 GC08M145737 GC08M145305 GC08M145704 GC08M145670 GC08M140814

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FOXH1:

FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates

an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FOXH1_HUMAN, O75593

Function: Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for

induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex

containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element)

Gene Wiki entry for FOXH1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_037704.5

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FOXH1 gene promoter:
Sp1 p53 Nkx2-5 AP-2alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FOXH1 promoter sequence

Search SABiosciences Chromatin IP Primers for FOXH1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXH1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24

FOXH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXH1 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M145669: view genomic region (about GC identifiers)

Start:	145,698,795 bp from pter	End:	145,701,718 bp from pter
Size:	2,924 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FOXH1_HUMAN, O75593 (See protein sequence)

Recommended Name: Forkhead box protein H1

Size: 365 amino acids; 39257 Da

Subunit: Interacts with the MH2 domains of SMAD2 and SMAD3

Subcellular location: Nucleus

Secondary accessions: D3DWM4

Explore the universe of human proteins at neXtProt for FOXH1: NX_O75593

FOXH1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003914.1

ENSEMBL proteins:

ENSP00000366534

Reactome Protein details: O75593
Human Recombinant Protein Products:

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	Uscn Proteins for FOXH1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	16120611
GO:0005654	nucleoplasm	TAS	--
GO:0005667	transcription factor complex	IDA	17438144
GO:0032444	activin responsive factor complex	IDA	9389648

FOXH1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for FOXH1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FOXH1 for domains About GeneDecksing

3 InterPro domains/families:

IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

IPR018122 TF_fork_head_CS

IPR001766 TF_fork_head

Graphical View of Domain Structure for InterPro Entry O75593

ProtoNet protein and cluster: O75593

UniProtKB/Swiss-Prot: FOXH1_HUMAN, O75593

Domain: The FM region is required for binding SMAD2/SMAD4 complexes. FM2 is more effective than FM1 and only interacts

with phosphorylated SMAD2 that is in an activated SMAD complex (By similarity)

Similarity: Contains 1 fork-head DNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FOXH1_HUMAN, O75593

Function: Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for

induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex

containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element)

Genatlas biochemistry entry for FOXH1:

forkhead box H1,TGF-beta/activin signal transducer,Xenopus homolog,ubiquitously expressed,also expressed in several

cancer cell lines binding SMAD2 (MADH2) and activating response element (ARE),may be in injunction with SMAD4 (MADH4)

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		7 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXH1:
		hsa-miR-18a hsa-miR-361-3p hsa-miR-3134 hsa-miR-1193 hsa-miR-18b hsa-miR-452 hsa-miR-4287
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXH1

Gene Ontology (GO): 5/16 molecular function terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001104	RNA polymerase II transcription cofactor activity	IEA	--
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription	IEA	--
GO:0003677	contributes to DNA binding	IDA	9389648
GO:0003690	double-stranded DNA binding	IBA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	NAS	17507406

FOXH1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for FOXH1:

Elongated cells

Animal Models:
Mouse knock-outs for FOXH1: Foxh1^tm1Jlw Foxh1^tm1.1Hmd
13 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Foxh1):

cardiovascular system	craniofacial	digestive/alimentary	embryogenesis	growth/size
hematopoietic system	homeostasis/metabolism	immune system	mortality/aging	muscle
nervous system	renal/urinary system	respiratory system

FOXH1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development_TGF-beta receptor signaling

Development_TGF-beta receptor signaling

1.00

Development TGF-beta receptor signaling

0.96

Signaling by NODAL

Signaling by NODAL

1.00

Signaling by Activin

0.36

Signal transduction Activin A signaling regulation

Signal transduction Activin A signaling regulation

1.00

Signal transduction_Activin A signaling regulation

0.96

SMAD Signaling Network

SMAD Signaling Network

1.00

TGF Beta Signaling Pathway

TGF Beta Signaling Pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for FOXH1

	Signal transduction Activin A signaling regulation
	Development TGF-beta receptor signaling

1 R&D Systems Pathway for FOXH1

TGF-beta Signaling Pathways

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FOXH1

	SMAD Signaling Network
	BMP Pathway
	TGF-Beta Pathway

2 GeneGo (Thomson Reuters) Pathways for FOXH1

	Signal transduction Activin A signaling regulation
	Development TGF-beta receptor signaling

4 BioSystems Pathways for FOXH1

	TGF Beta Signaling Pathway
	Heart Development
	TGF-beta Receptor Signaling Pathway
	Regulation of nuclear SMAD2/3 signaling

4 Reactome Pathways for FOXH1

	Signaling by Activin
	Developmental Biology
	Signal Transduction
	Signaling by NODAL

FOXH1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FOXH1

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

5/23 Interacting proteins for FOXH1 (O75593^{1, 2, 3} ENSP00000366534⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 23)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PIK3R1	P27986²^,³, ENSP00000274335⁴	MINT-8111991 I2D: score=3 STRING: ENSP00000274335
NCK1	P16333¹^,³, ENSP00000288986⁴	EBI-1759806,EBI-3448658 I2D: score=2 STRING: ENSP00000288986
SMAD2	Q15796³, ENSP00000262160⁴	I2D: score=5 STRING: ENSP00000262160
SMAD3	P84022³, ENSP00000332973⁴	I2D: score=5 STRING: ENSP00000332973
GSC	P56915³, ENSP00000238558⁴	I2D: score=1 STRING: ENSP00000238558

About this table

Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	--	--
GO:0001568	blood vessel development	IBA	--
GO:0001947	heart looping	IBA	--
GO:0003139	secondary heart field specification	IEA	--
GO:0003146	NOT heart jogging	IRD	--

FOXH1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FOXH1
Search CenterWatch for drugs/clinical trials and news about FOXH1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FOXH1 gene:

NM_003923.2

Unigene Cluster for FOXH1:

Forkhead box H1

Hs.708365 [show with all ESTs]

Unigene Representative Sequence: NM_003923

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000377317(uc003zdc.3) ENST00000525197

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOXH1
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXH1:
		hsa-miR-18a hsa-miR-361-3p hsa-miR-3134 hsa-miR-1193 hsa-miR-18b hsa-miR-452 hsa-miR-4287
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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXH1

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		GenScript: all cDNA clones in your preferred vector: FOXH1 (NM_003923)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXH1

Additional cDNA sequence:

AF076292.1 BC051376.1 BC065377.1

2 DOTS entries:

DT.97785833 DT.40118402

24 AceView cDNA sequences:

AI632666 BC065377 AA548116 AI636647 BC051376 AI699939 AW235176 NM_003923

BE550635 AW451014 AI651640 CD048780 AF076292 AI631625 BE829294 AI916797

BE504812 BU855499 BF057145 H14209 BU859593 AI917314 AA218611 BF987037

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for FOXH1 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b
SP1:
SP2:					-

ECgene alternative splicing isoforms for FOXH1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FOXH1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCCTGGTGG

About this image

FOXH1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/11 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 11)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Myocardium

Myocardium

Myocardium

Cardiac Crescent Cells

Myocardium

Myocardium

Primitive Heart Tube Cells

Myocardium

Early Embryo

Extraembryonic Tissues

Hypoblast

Visceral Endoderm

Early Distal Visceral Endoderm Cells

Extraembryonic Tissues, Yolk Sac

Inner Cell Mass

Inner Cell Mass Cells

Early Embryo

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

See FOXH1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FOXH1

SOURCE GeneReport for Unigene cluster: Hs.708365

UniProtKB/Swiss-Prot: FOXH1_HUMAN, O75593

Tissue specificity: Ubiquitous

SABiosciences Custom PCR Arrays for FOXH1

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXH1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FOXH1 gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	FOXH1⁶	--	34(a)	1 ↔ 1	GL343750.1(234845-237885)
African clawed frog (Xenopus laevis)	Amphibia	LOC398070²	forkhead activin signal transducer 1	73.05(n)		U70980.1
zebrafish (Danio rerio)	Actinopterygii	foxh1²	forkhead box H1	71.62(n)		57930 AF263000.1
worm (Caenorhabditis elegans)	Secernentea	fkh-6⁶	ForKHead transcription factor family member (fkh-6...	16(a)	1 → many	II(4379886-4383290)

ENSEMBL Gene Tree for FOXH1 (if available)
TreeFam Gene Tree for FOXH1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FOXH1 gene

1 SIMAP similar gene for FOXH1 using alignment to 2 protein entries: FOXH1_HUMAN (see all proteins):

FOXA1

FOXH1 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for FOXH1
PGOHUM00000243244 PGOHUM00000236348

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183946498^1,2		--	145698909(+)	`CCAGAC/GTCACC`	2	--	ds500¹ ut3¹		0	--	--	--	--
rs188887895^1,2		--	145698921(+)	`CTCCAC/TCTCCG`	2	--	ds500¹ ut3¹		0	--	--	--	--
rs74360910^1,2	F,	--	145699310(+)	`GTGACG/AGCTGG`	2	--	ut3¹		1		EA	120
rs11781640^1,2	C,F,H,	--	145699388(+)	`TCCTGC/TAGCTT`	2	--	ut3¹		4		NS NA	280
rs148389554^1,2		--	145699449(+)	`GCCCAC/GCTGGG`	2	--	ut3¹		0	--	--	--	--
rs192907579^1,2		--	145699566(+)	`TCCCTA/GTCAAC`	2	--	int¹ ut3¹		0	--	--	--	--
rs2721176^1,2	C,H,	--	145699601(+)	`AGGAGC/TGGCCC`	2	--	int¹ ut3¹		12		WA NA CSA EA	375
rs201981529^1,2		--	145699620(+)	`AGAGCC/TTCACA`	2	--	ut3¹ int¹		0	--	--	--	--
rs7833404^1,2	C,F,H,	--	145699642(+)	`GAGAGC/TAGCCA`	3	L	int¹ syn¹ ese³		6		NS NA WA	4374
rs142762918^1,2	F	--	145699663(+)	`GGGGCC/TGCCAG`	3	A	syn¹ int¹		1		NA	4178

HapMap Linkage Disequilibrium report for FOXH1 (145698795 - 145701718 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for FOXH1
4 CNVs: 4613 23292 53129 30306
Human Gene Mutation Database (HGMD): FOXH1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOXH1

DNA2.0 Custom Variant and Variant Library Synthesis for FOXH1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FOXH1 for disorders           About GeneDecksing

OMIM gene information: 603621    OMIM disorders: --

7 diseases for FOXH1:    About MalaCards

friedreich ataxia angioedema holoprosencephaly prostate cancer

ataxia prostatitis glioblastoma

1 disease from the University of Copenhagen DISEASES database for FOXH1:

Angioedema

Human Genome Epidemiology (HuGE) Navigator: FOXH1 (2 documents)

Export disorders for FOXH1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FOXH1 gene, integrated from 9 sources (see all 46):
(articles sorted by number of sources associating them with FOXH1)

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Characterization of human FAST-1, a TGF beta and activin signal transducer. (PubMed id 9702198)^{1, 2, 3, 9} Zhou S.... Vogelstein B. (1998)
Expression of the FAST-1 transcription factor in coronary artery transplant vasculopathy and activated vascular smooth muscle cells. (PubMed id 15737749)^{1, 9} Kelemen S.F....Autieri M.V. (2005)
BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners. (PubMed id 10938097)^{1, 9} Dou C....Lai E. (2000)
Selective inhibition of TGF-beta responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP. (PubMed id 15750622)^{1, 9} Cui Q....Hoffmann F.M. (2005)
HEB and E2A function as SMAD/FOXH1 cofactors. (PubMed id 21828274)¹ Yoon S.J....Baker J.C. (2011)
An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)¹ Ravasi T....Hayashizaki Y. (2010)
Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)¹ Jugessur A....Murray J.C. (2010)
PKA-mediated stabilization of FoxH1 negatively regula tes ERalpha activity. (PubMed id 19711044)¹ Yum J....Yeo C.Y. (2009)
Forkhead box H1 (FOXH1) sequence variants in ventricu lar septal defect. (PubMed id 19525021)¹ Wang B....Ma X. (2009)
SMAD proteins of oligodendroglial cells regulate trans cription of JC virus early and late genes coordinately with the Tat protein of h uman immunodeficiency virus type 1. (PubMed id 19420158)¹ Stettner M.R....Johnson E.M. (2009)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8928	HGNC: 3814	AceView: FOXH1	Ensembl:ENSG00000160973	euGenes: HUgn8928
ECgene: FOXH1	H-InvDB: FOXH1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for FOXH1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FOXH1 gene
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