Aliases for FOXH1 Gene
External Ids for FOXH1 Gene
Previous GeneCards Identifiers for FOXH1 Gene
FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT. [provided by RefSeq, Jul 2008]
GeneCards Summary for FOXH1 Gene
FOXH1 (Forkhead Box H1) is a Protein Coding gene. Diseases associated with FOXH1 include Alobar Holoprosencephaly and Septopreoptic Holoprosencephaly. Among its related pathways are Packaging Of Telomere Ends and Signaling by GPCR. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein domain specific binding. An important paralog of this gene is FOXG1.
UniProtKB/Swiss-Prot for FOXH1 Gene
Transcriptional activator. Recognizes and binds to the DNA sequence 5-TGT[GT][GT]ATT-3. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).