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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FOXG1 Gene

protein-coding   GIFtS: 56
GCID: GC14P029235

forkhead box G1

(Previous names: forkhead box G1B, forkhead box G1C, forkhead box G1A )
(Previous symbols: FKHL2, FOXG1B, FKHL4, FKH2, FKHL1, FOXG1C, FKHL3, FOXG1A)
 Explore 20 diseases affiliated with
FOXG1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FOXG1    

Aliases
for FOXG1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Forkhead Box G11 2     FHKL32
BF11 2 3 5     HBF-12
FKH21 2 3 5     HBF-22
FKHL11 2 3 5     HBF-G22
FOXG1B1 2 3 5     HBF22
FKHL21 2 3     KHL22
FKHL31 2 3     Forkhead Box Protein G12
FKHL41 2 3     Forkhead-Like 12
FOXG1A1 2 3     Forkhead-Like 22
FOXG1C1 2 3     Forkhead-Like 32
HFK11 2 3     Forkhead-Like 42
HFK21 2 3     Oncogene QIN2
HFK31 2 3     BF-13
QIN1 2 5     BF-23
HBF-31 2     Forkhead Box Protein G1A3
Brain Factor 12 3     Forkhead Box Protein G1B3
Brain Factor 22 3     Forkhead Box Protein G1C3
BF22 3     Forkhead-Related Protein FKHL13
Forkhead Box G1A1     Forkhead-Related Protein FKHL23
Forkhead Box G1B1     Forkhead-Related Protein FKHL33
Forkhead Box G1C1     HBF-22

External Ids:    HGNC: 38111   Entrez Gene: 22902   Ensembl: ENSG000001761657   OMIM: 1648745   UniProtKB: P553163   

Export aliases for FOXG1 gene to outside databases

Previous GC identifers: GC14P028306 GC14P009354


Summaries
for FOXG1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FOXG1:
This locus encodes a member of the forked-head transcription factor family. The encoded protein, which functions as a
repressor, may play a role in brain development. Mutations at this locus have been associated with Rett syndrome.
(provided by RefSeq, Feb 2012)

UniProtKB/Swiss-Prot: FOXG1_HUMAN, P55316
Function: Transcription repression factor which plays an important role in the establishment of the regional
subdivision of the developing brain and in the development of the telencephalon

Gene Wiki entry for FOXG1


Genomic Views
for FOXG1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FOXG1 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   POU2F2   POU2F1   FOXO4   HFH-1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FOXG1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FOXG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q11-q13

FOXG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXG1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P029235:  view genomic region     (about GC identifiers)

Start:
 29,235,050 bp from pter      End:
 29,238,871 bp from pter
Size:
 3,822 bases      Orientation:
 plus strand

Proteins
for FOXG1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FOXG1_HUMAN, P55316 (See protein sequence)
Recommended Name: Forkhead box protein G1  
Size: 489 amino acids; 52352 Da
Subunit: Interacts with KDM5B
Subcellular location: Nucleus
Caution: PubMed:7959731 claims that there are 3 different FOXG1 proteins, FOXG1A, FOXG1B, and FOXG1C. It was latter
found that there is only one gene and the differences between these three may be sequencing errors since the protein
is coded in a unique exon
Secondary accessions: A6NFY2 P55315 Q14488 Q86XT7

Explore the universe of human proteins at neXtProt for FOXG1: NX_P55316

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P55316

    • FOXG1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005240.3  
    ENSEMBL proteins: 
     ENSP00000371975   ENSP00000339004  

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    Novus Biologicals FOXG1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FOXG1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--
    GO:0005667transcription factor complex IBA--


    FOXG1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for FOXG1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FOXG1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry P55316

    ProtoNet protein and cluster: P55316

    UniProtKB/Swiss-Prot: FOXG1_HUMAN, P55316
    Similarity: Contains 1 fork-head DNA-binding domain


    Function
    for FOXG1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FOXG1_HUMAN, P55316
    Function: Transcription repression factor which plays an important role in the establishment of the regional
    subdivision of the developing brain and in the development of the telencephalon

    miRNA
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    hsa-miR-124* hsa-miR-548j hsa-miR-376b hsa-miR-30d hsa-miR-374a hsa-miR-30a hsa-miR-4274 hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: FOXG1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOXG1 (see all 7)
    OriGene shRNA RFP: FOXG1
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for FOXG1

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXG1

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS7959731
    GO:0003690double-stranded DNA binding IBA--
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IBA--
    GO:0005515protein binding IPI12657635
    GO:0008134transcription factor binding IBA--


    FOXG1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for FOXG1:
     Decreased Hepatitis C virus re 

    Animal Models:
         15/21 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Foxg1) (see all 21):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  muscle 

    FOXG1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FOXG1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signal transduction Activin A signaling regulation
    		Signal transduction Activin A signaling regulation1.00
    		Signal transduction_Activin A signaling regulation0.96
    2Transcription factors in neurogenesis
    		Transcription factors in neurogenesis1.00
    3TGF-beta Receptor Signaling Pathway
    		TGF-beta Receptor Signaling Pathway1.00
    4Regulation of nuclear SMAD2/3 signaling
    		Regulation of nuclear SMAD2/3 signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for FOXG1
        Transcription factors in neurogenesis
    Signal transduction Activin A signaling regulation


    1 GeneGo (Thomson Reuters) Pathway for FOXG1
        Signal transduction Activin A signaling regulation

    2 BioSystems Pathways for FOXG1 
        TGF-beta Receptor Signaling Pathway
    Regulation of nuclear SMAD2/3 signaling



    FOXG1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FOXG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/20 Interacting proteins for FOXG1 (P553163 ENSP000003390044) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FOXO1Q127783, ENSP000003688804I2D: score=2 STRING: ENSP00000368880
    FOXO3O435243, ENSP000003395274I2D: score=2 STRING: ENSP00000339527
    FOXO4P981773, ENSP000003633774I2D: score=2 STRING: ENSP00000363377
    SMAD2Q157963, ENSP000002621604I2D: score=1 STRING: ENSP00000262160
    SMAD3P840223, ENSP000003329734I2D: score=1 STRING: ENSP00000332973
    About this table

    Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002052positive regulation of neuroblast proliferation IBA--
    GO:0006355regulation of transcription, DNA-dependent NAS--
    GO:0007346regulation of mitotic cell cycle IBA--
    GO:0007420brain development TAS7599184
    GO:0007568aging IEA--


    FOXG1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FOXG1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FOXG1
    Search CenterWatch for drugs/clinical trials and news about FOXG1 

    Transcripts
    for FOXG1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FOXG1 gene: 
    NM_005249.4  

    Unigene Clusters for FOXG1:

    Forkhead box G1
    Hs.632336  [show with all ESTs], Hs.741222  [show with all ESTs]
    Unigene Representative Sequences: NM_005249, BC050072
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382535 ENST00000313071(uc001wqe.3)

    miRNA
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    8/70 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXG1 (see all 70):
    hsa-miR-124* hsa-miR-548j hsa-miR-376b hsa-miR-30d hsa-miR-374a hsa-miR-30a hsa-miR-4274 hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: FOXG1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOXG1 (see all 7)
    OriGene shRNA RFP: FOXG1
    OriGene siRNA: FOXG1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXG1
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXG1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXG1

    Additional cDNA sequence: 

    BC050072.1 X74144.1 

    6 DOTS entries:

    DT.453370  DT.91952337  DT.100748690  DT.95361559  DT.95269931  DT.207724 

    9 AceView cDNA sequences:

    BI915241 BX410672 BX440747 BX408766 BG910224 BX404748 BI913371 BG912675 
    BX410673 

    GeneLoc Exon Structure


    Expression
    for FOXG1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FOXG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAACTATATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FOXG1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural EctodermNeural PlateAnterior Neural Ridge CellsNeural Ectoderm
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    LimbForelimb MyotomeLimb Muscle Progenitor CellsSkeletal Muscle
    OvaryAntral FollicleCumulus CellsOvary
    BoneMaxillary ProcessBone
    BrainHypothalamusBrain
    Head MesenchymeFrontonasal ProcessHead Mesenchyme
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
    Floating neuronal aggregates (Generation of choroi...)
    Anterior foregut progenitor cells (Directed differentia...)
    Motor neurons progenitors (Motor neuron differe...)
    Beating cell clusters (Spontaneous differen...)

    See FOXG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FOXG1

    SOURCE GeneReport for Unigene clusters: Hs.632336 Hs.741222

    UniProtKB/Swiss-Prot: FOXG1_HUMAN, P55316
    Tissue specificity: Expression is restricted to the neurons of the developing telencephalon

        SABiosciences Expression via Pathway-Focused PCR Arrays including FOXG1: 
              Cell Lineage Identification in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Transcription Factors in human mouse rat
              Diabetes in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXG1

    Orthologs
    for FOXG1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FOXG1 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FOXG11 forkhead box G1 88.62(n)
    92.02(a)    		   396110  NM_205193.1  NP_990524.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FOXG16
    		 --
    		 76(a)
    		 1 ↔ 1
    		 1(27434011-27435459)
    African clawed frog
    (Xenopus laevis)    		 Amphibia foxg1b-A-prov2 winged-helix transcription factor 79.03(n)    AF101387.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii foxg12 forkhead box G1 78.25(n)   30274  AF067204.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta slp26
    fd19B6
    (see all 3)    		 forkhead domain 19B
    (see all 3)    		 29(a)
    25(a)
    (see all 3)    		 1 ↔ 1
    possible ortholog
    (see all 3)    		 2L(3836842-3839201)
    X(19985636-19986418)
    worm
    (Caenorhabditis elegans)    		 Secernentea fkh-26
    pes-16
    		 Patterned Expression Site family member (pes-1)
    		 35(a)
    19(a)
    		 1 ↔ 1
    possible ortholog
    		 X(3740194-3742309)
    IV(5002744-5005339)


    ENSEMBL Gene Tree for FOXG1 (if available)
    TreeFam Gene Tree for FOXG1 (if available) 

    Paralogs
    for FOXG1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FOXG1 gene
    FOXJ12  FOXN32  FOXK12  FOXN42  FOXN12  FOXK22  FOXP42  FOXJ32  
    FOXJ22  FOXP22  FOXN22  FOXP32  FOXP12  
    2 SIMAP similar genes for FOXG1 using alignment to 1 protein entry:     FOXG1_HUMAN:
    FOXL2    FOXB1

    FOXG1 for paralogs           About GeneDecksing



    Genomic Variants
    for FOXG1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/61 NCBI SNPs in FOXG1 are shown (see all 61)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1387470731,2
    		Cpathogenic29237685(+) ACCTAC/G/TTCCCT 3 Y * stg1 syn11NA 4442
    rs1820655861,2
    		--29234385(+) AAAAGG/TTGCCT 1 -- us2k10--------
    rs1164292251,2
    		C,F,--29234441(+) CCGTAA/GAATGT 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs125890131,2
    		C,F,H,--29234608(+) CAACCG/AAACCT 1 -- us2k111Minor allele frequency- A:0.09NS EA NA 1056
    rs1848729171,2
    		--29234718(+) CAGTAC/TACTGT 1 -- us2k10--------
    rs2011755021,2
    		--29234775(+) AAAGG-/AAAAAA 1 -- us2k10--------
    rs1475431071,2
    		--29234995(+) GCAGGA/GGAGAA 1 -- us2k10--------
    rs777339561,2
    		C--29235179(+) GGTGCA/CGGAGC 1 -- us2k10--------
    rs1402648121,2
    		--29235282(+) TCGCTC/TCCAAA 1 -- us2k10--------
    rs1884138561,2
    		--29235377(+) GCTGCG/TCTAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FOXG1 (29235050 - 29238871 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FOXG1: --
    Human Gene Mutation Database (HGMD): FOXG1

    SABiosciences Cancer Mutation PCR Assays
    2 SABiosciences qBiomarker Copy Number PCR Arrays containing FOXG1:
    Birth Defects
    Intellectual Disability
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOXG1
    DNA2.0 Custom Variant and Variant Library Synthesis for FOXG1

    Disorders / Diseases
    for FOXG1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FOXG1 for disorders           About GeneDecksing

    OMIM gene information: 164874   
    OMIM disorders: 613454  
    UniProtKB/Swiss-Prot: FOXG1_HUMAN, P55316
  • Defects in FOXG1 are the cause of congenital variant of Rett syndrome (RTTCV) [MIM:613454]. RTTCV is a severe
    • neurodevelopmental disorder with features of classic Rett syndrome but earlier onset in the first months of life.
    Clinical features include progressive microcephaly, hypotonia, irresponsiveness and irritability in the neonatal
    period, mental retardation, psychomotor regression and stereotypical movements

    20 diseases for FOXG1:    About MalaCards
    maternal uniparental disomy, chromosome 14    rett syndrome    autoimmune thrombocytopenic purpura    classic rett syndrome
    intellectual disability    brain malformations    west syndrome    purpura
    holoprosencephaly    lupus erythematosus    multiple sclerosis    microcephaly
    hypotonia    medulloblastoma    breast cancer    glioblastoma
    cerebritis    retinitis    melanoma    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for FOXG1:
    Rett syndrome     Microcephaly
    Human Genome Epidemiology (HuGE) Navigator: FOXG1 (2 documents)

    Export disorders for FOXG1 gene to outside databases

    Publications
    for FOXG1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FOXG1 gene, integrated from 9 sources (see all 59):
    (articles sorted by number of sources associating them with FOXG1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human brain factor 1, a new member of the fork head gene family. (PubMed id 7959731)1, 2, 3, 9 Murphy D.B.... Thies U. (1994)
    2. Comparative evolutionary analysis of the FoxG1 transcription factor from diverse vertebrates identifies conserved recognition sites for microRNA regulation. (PubMed id 17260156)1, 2, 3 Bredenkamp N....Illing N. (2007)
    3. Human PLU-1 has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9. (PubMed id 12657635)1, 2, 9 Tan K....Freemont P.S. (2003)
    4. The genes for human brain factor 1 and 2, members of the fork head gene family, are clustered on chromosome 14q. (PubMed id 7599184)1, 2, 9 Wiese S.... Thies U. (1995)
    5. A missense mutation within the fork-head domain of th e forkhead box G1 Gene (FOXG1) affects its nuclear localization. (PubMed id 21280142)1, 2 Le Guen T....Bienvenu T. (2011)
    6. Novel FOXG1 mutations associated with the congenital variant of Rett syndrome. (PubMed id 19578037)1, 2 Mencarelli M.A....Renieri A. (2010)
    7. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    8. The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription. (PubMed id 11238932)1, 9 Yao J....Stifani S. (2001)
    9. BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners. (PubMed id 10938097)1, 9 Dou C....Lai E. (2000)
    10. Haploinsufficiency of novel FOXG1B variants in a patient with severe mental retardation, brain malformations and microcephaly. (PubMed id 16133170)1, 9 Shoichet S.A....Kalscheuer V.M. (2005)

    External Searches for FOXG1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
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    Genome Databases showing FOXG1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2290 HGNC: 3811 AceView: FOXG1B Ensembl:ENSG00000176165 euGenes: HUgn2290
    ECgene: FOXG1 H-InvDB: FOXG1

    Other Databases showing FOXG1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FOXG1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FOXG1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/FOXG1

    Intellectual Property
    for FOXG1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FOXG1 gene:
    Search GeneIP for patents involving FOXG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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