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Aliases for FOXG1 Gene

Aliases for FOXG1 Gene

  • Forkhead Box G1 2 3
  • Brain Factor 1 3 4
  • Brain Factor 2 3 4
  • FOXG1A 3 4
  • FOXG1B 3 4
  • FOXG1C 3 4
  • HBF-2 3 4
  • FKHL1 3 4
  • FKHL2 3 4
  • FKHL3 3 4
  • FKHL4 3 4
  • FKH2 3 4
  • HFK1 3 4
  • HFK2 3 4
  • HFK3 3 4
  • BF1 3 4
  • BF2 3 4
  • Forkhead-Related Protein FKHL1 4
  • Forkhead-Related Protein FKHL2 4
  • Forkhead-Related Protein FKHL3 4
  • Forkhead Box Protein G1A 4
  • Forkhead Box Protein G1B 4
  • Forkhead Box Protein G1C 4
  • Forkhead Box G1B 2
  • Forkhead Box G1C 2
  • Forkhead Box G1A 2
  • Forkhead-Like 1 3
  • Forkhead-Like 2 3
  • Forkhead-Like 3 3
  • Forkhead-Like 4 3
  • Oncogene QIN 3
  • HBF-G2 3
  • FHKL3 3
  • HBF-1 3
  • HBF-3 3
  • HBF2 3
  • KHL2 3
  • BF-1 4
  • BF-2 4
  • QIN 3

External Ids for FOXG1 Gene

Previous HGNC Symbols for FOXG1 Gene

  • FKHL2
  • FOXG1B
  • FKHL4
  • FKH2
  • FKHL1
  • FOXG1C
  • FKHL3
  • FOXG1A

Previous GeneCards Identifiers for FOXG1 Gene

  • GC14P028306
  • GC14P029235
  • GC14P009354

Summaries for FOXG1 Gene

Entrez Gene Summary for FOXG1 Gene

  • This locus encodes a member of the forked-head transcription factor family. The encoded protein, which functions as a repressor, may play a role in brain development. Mutations at this locus have been associated with Rett syndrome. [provided by RefSeq, Feb 2012]

GeneCards Summary for FOXG1 Gene

FOXG1 (Forkhead Box G1) is a Protein Coding gene. Diseases associated with FOXG1 include 14q12 microdeletion syndrome and 14q11.2 microduplication syndrome. Among its related pathways are Regulation of nuclear SMAD2/3 signaling and TGF-beta Receptor Signaling Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is FOXK2.

UniProtKB/Swiss-Prot for FOXG1 Gene

  • Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.

Gene Wiki entry for FOXG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXG1 Gene

Genomics for FOXG1 Gene

Regulatory Elements for FOXG1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FOXG1 Gene

Chromosome:
14
Start:
28,765,388 bp from pter
End:
28,770,277 bp from pter
Size:
4,890 bases
Orientation:
Plus strand

Genomic View for FOXG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for FOXG1 Gene

Proteins for FOXG1 Gene

  • Protein details for FOXG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55316-FOXG1_HUMAN
    Recommended name:
    Forkhead box protein G1
    Protein Accession:
    P55316
    Secondary Accessions:
    • A6NFY2
    • P55315
    • Q14488
    • Q86XT7

    Protein attributes for FOXG1 Gene

    Size:
    489 amino acids
    Molecular mass:
    52352 Da
    Quaternary structure:
    • Interacts with KDM5B.

neXtProt entry for FOXG1 Gene

Proteomics data for FOXG1 Gene at MOPED

Post-translational modifications for FOXG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FOXG1 Gene

Domains & Families for FOXG1 Gene

Gene Families for FOXG1 Gene

Protein Domains for FOXG1 Gene

Suggested Antigen Peptide Sequences for FOXG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55316

UniProtKB/Swiss-Prot:

FOXG1_HUMAN :
  • Contains 1 fork-head DNA-binding domain.
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXG1: view

Function for FOXG1 Gene

Molecular function for FOXG1 Gene

UniProtKB/Swiss-Prot Function:
Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.

LifeMap Function Summary for FOXG1 Gene

FOXG1 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for FOXG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 7957066
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 12657635
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXG1: view
genes like me logo Genes that share phenotypes with FOXG1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOXG1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FOXG1 Gene

Localization for FOXG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXG1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXG1 Gene COMPARTMENTS Subcellular localization image for FOXG1 gene
Compartment Confidence
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for FOXG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with FOXG1: view

Pathways & Interactions for FOXG1 Gene

genes like me logo Genes that share pathways with FOXG1: view

Pathways by source for FOXG1 Gene

1 KEGG pathway for FOXG1 Gene
1 GeneGo (Thomson Reuters) pathway for FOXG1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for FOXG1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for FOXG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0007420 brain development IEA --
GO:0007568 aging IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 12657635
genes like me logo Genes that share ontologies with FOXG1: view

Drugs & Compounds for FOXG1 Gene

No Compound Related Data Available

Transcripts for FOXG1 Gene

mRNA/cDNA for FOXG1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXG1 Gene

Forkhead box G1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOXG1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXG1 Gene

No ASD Table

Relevant External Links for FOXG1 Gene

GeneLoc Exon Structure for
FOXG1
ECgene alternative splicing isoforms for
FOXG1

Expression for FOXG1 Gene

mRNA expression in normal human tissues for FOXG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXG1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.5), Brain - Cortex (x6.5), Brain - Anterior cingulate cortex (BA24) (x6.4), Brain - Nucleus accumbens (basal ganglia) (x6.1), Brain - Putamen (basal ganglia) (x5.8), Brain - Caudate (basal ganglia) (x5.7), Brain - Hippocampus (x5.6), and Brain - Amygdala (x5.2).

Protein differential expression in normal tissues from HIPED for FOXG1 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FOXG1 Gene



SOURCE GeneReport for Unigene cluster for FOXG1 Gene Hs.632336

mRNA Expression by UniProt/SwissProt for FOXG1 Gene

P55316-FOXG1_HUMAN
Tissue specificity: Expression is restricted to the neurons of the developing telencephalon.
genes like me logo Genes that share expression patterns with FOXG1: view

Protein tissue co-expression partners for FOXG1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for FOXG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXG1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOXG1 35
  • 95.57 (n)
  • 97.54 (a)
mouse
(Mus musculus)
Mammalia Foxg1 35
  • 93.9 (n)
  • 95.43 (a)
Foxg1 16
Foxg1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FOXG1 35
  • 99.29 (n)
  • 99.76 (a)
FOXG1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxg1 35
  • 93.89 (n)
  • 95.83 (a)
dog
(Canis familiaris)
Mammalia FOXG1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FOXG1 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOXG1 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOXG1 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXG1 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia foxg1 35
  • 82.64 (n)
  • 97.11 (a)
African clawed frog
(Xenopus laevis)
Amphibia foxg1b-A-prov 35
zebrafish
(Danio rerio)
Actinopterygii foxg1 35
foxg1a 35
  • 75 (n)
  • 89.94 (a)
foxg1a 36
  • 84 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta fd19B 36
  • 31 (a)
OneToMany
slp1 36
  • 34 (a)
OneToMany
slp2 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea fkh-2 36
  • 43 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToOne
Species with no ortholog for FOXG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FOXG1 Gene

ENSEMBL:
Gene Tree for FOXG1 (if available)
TreeFam:
Gene Tree for FOXG1 (if available)

Paralogs for FOXG1 Gene

(1) SIMAP similar genes for FOXG1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXG1: view

Variants for FOXG1 Gene

Sequence variations from dbSNP and Humsavar for FOXG1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1042761 -- 28,769,293(+) AATGC(A/G)CTTGG utr-variant-3-prime
rs1042762 -- 28,769,349(+) GCAAC(A/G)CTGCC utr-variant-3-prime
rs1042766 -- 28,769,642(+) ACACA(G/T)AAATA utr-variant-3-prime
rs1126890 -- 28,768,627(+) CCTCG(A/C)CCCCT reference, missense
rs34654108 Benign 28,768,512(-) TGGCC(C/T)GCGAG synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for FOXG1 Gene

Variant ID Type Subtype PubMed ID
nsv526536 CNV Gain 19592680
dgv1868n71 CNV Loss 21882294
nsv520282 CNV Loss 19592680
nsv1227 CNV Insertion 18451855
nsv826911 CNV Gain 20364138

Variation tolerance for FOXG1 Gene

Residual Variation Intolerance Score: 31.74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXG1 Gene

HapMap Linkage Disequilibrium report
FOXG1
Human Gene Mutation Database (HGMD)
FOXG1

PCR Panel Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXG1 Gene

Disorders for FOXG1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for FOXG1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
14q12 microdeletion syndrome
  • del(14)(q12)
14q11.2 microduplication syndrome
  • dup(14)(q11.2)
rett syndrome, congenital variant
  • rett syndrome congenital variant
foxg1 syndrome
  • foxg1-related disorder
rett syndrome
  • rett syndrome, preserved speech variant
- elite association
Search FOXG1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FOXG1_HUMAN
  • Rett syndrome congenital variant (RTTCV) [MIM:613454]: A severe neurodevelopmental disorder with features of classic Rett syndrome but earlier onset in the first months of life. Clinical features include progressive microcephaly, hypotonia, irresponsiveness and irritability in the neonatal period, mental retardation, psychomotor regression and stereotypical movements. {ECO:0000269 PubMed:19578037, ECO:0000269 PubMed:21280142}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for FOXG1

Genetic Association Database (GAD)
FOXG1
Human Genome Epidemiology (HuGE) Navigator
FOXG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXG1
genes like me logo Genes that share disorders with FOXG1: view

No data available for Genatlas for FOXG1 Gene

Publications for FOXG1 Gene

  1. Human brain factor 1, a new member of the fork head gene family. (PMID: 7959731) Murphy D.B. … Thies U. (Genomics 1994) 2 23 67
  2. Comparative evolutionary analysis of the FoxG1 transcription factor from diverse vertebrates identifies conserved recognition sites for microRNA regulation. (PMID: 17260156) Bredenkamp N. … Illing N. (Dev. Genes Evol. 2007) 2 67
  3. Haploinsufficiency of novel FOXG1B variants in a patient with severe mental retardation, brain malformations and microcephaly. (PMID: 16133170) Shoichet S.A. … Kalscheuer V.M. (Hum. Genet. 2005) 23 67
  4. Antagonistic effects of Grg6 and Groucho/TLE on the transcription repression activity of brain factor 1/FoxG1 and cortical neuron differentiation. (PMID: 16314515) MarAsal N. … Stifani S. (Mol. Cell. Biol. 2005) 23 67
  5. Foxd1 is required for proper formation of the optic chiasm. (PMID: 15509772) Herrera E. … Mason C. (Development 2004) 23 67

Products for FOXG1 Gene

Sources for FOXG1 Gene

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