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Aliases for FOXF2 Gene

Aliases for FOXF2 Gene

  • Forkhead Box F2 2 3
  • FREAC2 3 4 6
  • FKHL6 3 4 6
  • Forkhead-Related Transcription Factor 2 3 4
  • Forkhead-Related Protein FKHL6 3 4
  • Forkhead-Related Activator 2 3 4
  • FREAC-2 3 4
  • Forkhead Box Protein F2 3
  • Forkhead-Like 6 3

External Ids for FOXF2 Gene

Previous Symbols for FOXF2 Gene

  • FKHL6

Summaries for FOXF2 Gene

Entrez Gene Summary for FOXF2 Gene

  • FOXF2 encodes forkhead box F2, one of many human homologues of the Drosophila melanogaster transcription factor forkhead. FOXF2 is expressed in lung and placenta, and has been shown to transcriptionally activate several lung-specific genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXF2 Gene

FOXF2 (Forkhead Box F2) is a Protein Coding gene. Diseases associated with FOXF2 include duane retraction syndrome and blepharophimosis. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is FOXK2.

UniProtKB/Swiss-Prot for FOXF2 Gene

  • Probable transcription activator for a number of lung-specific genes

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXF2 Gene

Genomics for FOXF2 Gene

Genomic Location for FOXF2 Gene

Start:
1,389,834 bp from pter
End:
1,395,597 bp from pter
Size:
5,764 bases
Orientation:
Plus strand

Genomic View for FOXF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXF2 Gene

Regulatory Elements for FOXF2 Gene

Proteins for FOXF2 Gene

  • Protein details for FOXF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12947-FOXF2_HUMAN
    Recommended name:
    Forkhead box protein F2
    Protein Accession:
    Q12947
    Secondary Accessions:
    • Q5TGJ1
    • Q9UQ85

    Protein attributes for FOXF2 Gene

    Size:
    444 amino acids
    Molecular mass:
    45993 Da
    Quaternary structure:
    • Interacts with the transcription factors TBP and TFIIB.

neXtProt entry for FOXF2 Gene

Proteomics data for FOXF2 Gene at MOPED

Post-translational modifications for FOXF2 Gene

No Post-translational modifications

Other Protein References for FOXF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXF2 Gene

Domains for FOXF2 Gene

Gene Families for FOXF2 Gene

HGNC:
  • FOX :Forkhead boxes

Protein Domains for FOXF2 Gene

UniProtKB/Swiss-Prot:

FOXF2_HUMAN
Domain:
  • Two activation domains, AD1 and AD2, C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation.:
    • Q12947
  • Contains 1 fork-head DNA-binding domain.:
    • Q12947
genes like me logo Genes that share domains with FOXF2: view

Function for FOXF2 Gene

Molecular function for FOXF2 Gene

GENATLAS Biochemistry: transcription factor-like 6,with a Drosophila homeo forkhead DNA binding domain homolog,expressed in lung and placenta
UniProtKB/Swiss-Prot Function: Probable transcription activator for a number of lung-specific genes

Gene Ontology (GO) - Molecular Function for FOXF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 8626802
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IMP 8626802
GO:0003677 DNA binding IDA 7957066
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 9722567
GO:0008134 transcription factor binding IPI 9722567
genes like me logo Genes that share ontologies with FOXF2: view
genes like me logo Genes that share phenotypes with FOXF2: view

Animal Models for FOXF2 Gene

MGI Knock Outs for FOXF2:

miRNA for FOXF2 Gene

miRTarBase miRNAs that target FOXF2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FOXF2 Gene

Localization for FOXF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXF2 Gene COMPARTMENTS Subcellular localization image for FOXF2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for FOXF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9722567
GO:0005667 transcription factor complex IDA 9722567
genes like me logo Genes that share ontologies with FOXF2: view

Pathways for FOXF2 Gene

SuperPathways for FOXF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001837 epithelial to mesenchymal transition NAS 19220249
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0030198 extracellular matrix organization IEA --
GO:0042249 establishment of planar polarity of embryonic epithelium IEA --
genes like me logo Genes that share ontologies with FOXF2: view

No data available for Pathways by source for FOXF2 Gene

Transcripts for FOXF2 Gene

mRNA/cDNA for FOXF2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXF2 Gene

Forkhead box F2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXF2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c
SP1:
SP2: -

Relevant External Links for FOXF2 Gene

GeneLoc Exon Structure for
FOXF2
ECgene alternative splicing isoforms for
FOXF2

Expression for FOXF2 Gene

mRNA expression in normal human tissues for FOXF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXF2 Gene

This gene is overexpressed in Esophagus - Muscularis (12.4), Esophagus - Gastroesophageal Junction (11.3), and Colon - Sigmoid (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FOXF2 Gene

SOURCE GeneReport for Unigene cluster for FOXF2 Gene Hs.484423

mRNA Expression by UniProt/SwissProt for FOXF2 Gene

Q12947-FOXF2_HUMAN
Tissue specificity: Lung and placenta
genes like me logo Genes that share expressions with FOXF2: view

Orthologs for FOXF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FOXF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXF2 36
  • 97.96 (n)
  • 97.73 (a)
FOXF2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FOXF2 36
  • 90.31 (n)
  • 93.9 (a)
FOXF2 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXF2 36
  • 86.42 (n)
  • 83.99 (a)
FOXF2 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxf2 36
  • 84.44 (n)
  • 88.56 (a)
Foxf2 16
Foxf2 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FOXF2 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOXF2 37
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857760 36
  • 84.36 (n)
  • 84.23 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 87 (a)
OneToMany
-- 37
  • 75 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia foxf2 36
  • 76.77 (n)
  • 87.19 (a)
zebrafish
(Danio rerio)
Actinopterygii foxf2a 36
  • 72.2 (n)
  • 76.8 (a)
foxf2a 37
  • 70 (a)
OneToMany
foxf2b 37
  • 58 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1195 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 29 (a)
OneToMany
Species with no ortholog for FOXF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXF2 Gene

ENSEMBL:
Gene Tree for FOXF2 (if available)
TreeFam:
Gene Tree for FOXF2 (if available)

Paralogs for FOXF2 Gene

Selected SIMAP similar genes for FOXF2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXF2: view

Variants for FOXF2 Gene

Sequence variations from dbSNP and Humsavar for FOXF2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs729591 -- 1,395,542(-) AACTG(G/T)AAAAG utr-variant-3-prime
rs732835 -- 1,392,765(+) TGGAG(C/G)GGGTG intron-variant
rs910022 -- 1,393,655(+) CGTGG(G/T)TACGG intron-variant
rs910023 -- 1,393,950(+) GGTCC(A/G)GGCCT intron-variant
rs938723 -- 1,392,856(-) TCGGG(G/T)GTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOXF2 Gene

Variant ID Type Subtype PubMed ID
nsv883369 CNV Gain 21882294
nsv883370 CNV Gain 21882294
dgv6424n71 CNV Loss 21882294

Relevant External Links for FOXF2 Gene

HapMap Linkage Disequilibrium report
FOXF2
Human Gene Mutation Database (HGMD)
FOXF2

Disorders for FOXF2 Gene

(1) University of Copenhagen DISEASES for FOXF2 Gene

Relevant External Links for FOXF2

Genetic Association Database (GAD)
FOXF2
Human Genome Epidemiology (HuGE) Navigator
FOXF2
genes like me logo Genes that share disorders with FOXF2: view

No data available for UniProtKB/Swiss-Prot for FOXF2 Gene

Publications for FOXF2 Gene

  1. The two-exon gene of the human forkhead transcription factor FREAC-2 (FKHL6) is located at 6p25.3. (PMID: 9799607) Blixt A. … Carlsson P. (Genomics 1998) 2 3 4 23
  2. Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. (PMID: 7957066) Pierrou S. … Carlsson P. (EMBO J. 1994) 2 3 4
  3. Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2. (PMID: 8626802) Hellqvist M. … Carlsson P. (J. Biol. Chem. 1996) 3 4 23
  4. The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB. (PMID: 9722567) Hellqvist M. … Carlsson P. (J. Biol. Chem. 1998) 3 4 23
  5. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 49

Products for FOXF2 Gene

Sources for FOXF2 Gene

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