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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FOXF2 Gene

protein-coding   GIFtS: 54
GCID: GC06P001390

Forkhead Box F2


(Previous symbol: FKHL6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Forkhead Box F21 2     Forkhead-Related Transcription Factor 22 3
FKHL61 2 3 5     FREAC-22 3
FREAC22 3 5     Forkhead Box Protein F22
Forkhead-Related Activator 22 3     Forkhead-Like 62
Forkhead-Related Protein FKHL62 3     

External Ids:    HGNC: 38101   Entrez Gene: 22952   Ensembl: ENSG000001372737   OMIM: 6032505   UniProtKB: Q129473   

Export aliases for FOXF2 gene to outside databases

Previous GC identifers: GC06P001375 GC06P001335


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FOXF2 Gene:
FOXF2 encodes forkhead box F2, one of many human homologues of the Drosophila melanogaster transcription factor
forkhead. FOXF2 is expressed in lung and placenta, and has been shown to transcriptionally activate several
lung-specific genes. (provided by RefSeq, Jul 2008)

GeneCards Summary for FOXF2 Gene: 
FOXF2 (forkhead box F2) is a protein-coding gene. Diseases associated with FOXF2 include blepharophimosis, ptosis, and epicanthus inversus syndrome, and blepharophimosis. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOXF1.

UniProtKB/Swiss-Prot: FOXF2_HUMAN, Q12947
Function: Probable transcription activator for a number of lung-specific genes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FOXF2 gene promoter:
         GATA-1   C/EBPalpha   E47   CHOP-10   Pax-3   FOXO1a   Hand1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOXF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FOXF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25.3   Ensembl cytogenetic band:  6p25.3   HGNC cytogenetic band: 6p25.3

FOXF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXF2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P001390:  view genomic region     (about GC identifiers)

Start:
1,390,069 bp from pter      End:
1,395,832 bp from pter
Size:
5,764 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FOXF2_HUMAN, Q12947 (See protein sequence)
Recommended Name: Forkhead box protein F2  
Size: 444 amino acids; 45993 Da
Subunit: Interacts with the transcription factors TBP and TFIIB
Subcellular location: Nucleus
Secondary accessions: Q5TGJ1 Q9UQ85

Explore the universe of human proteins at neXtProt for FOXF2: NX_Q12947

Explore proteomics data for FOXF2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q12947

  • FOXF2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FOXF2 Protein Expression
    REFSEQ proteins: NP_001443.1  
    ENSEMBL proteins: 
     ENSP00000259806  

    Human Recombinant Protein Products for FOXF2: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FOXF2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9722567
    GO:0005667transcription factor complex IDA9722567

    FOXF2 for ontologies           About GeneDecksing



    FOXF2 Antibody Products: 
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    Assay Products for FOXF2: 
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    Cloud-Clone Corp. ELISAs for FOXF2 
    Cloud-Clone Corp. CLIAs for FOXF2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FOX: Forkhead boxes

    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry Q12947

    ProtoNet protein and cluster: Q12947

    UniProtKB/Swiss-Prot: FOXF2_HUMAN, Q12947
    Domain: Two activation domains, AD1 and AD2, C-terminal of (and distinct from) the forkhead domains are necessary
    for transcriptional activation
    Similarity: Contains 1 fork-head DNA-binding domain


    FOXF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOXF2_HUMAN, Q12947
    Function: Probable transcription activator for a number of lung-specific genes

         Genatlas biochemistry entry for FOXF2:
    transcription factor-like 6,with a Drosophila homeo forkhead DNA binding domain homolog,expressed in lung and
    placenta

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA7957066
    GO:0003690double-stranded DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IDA9722567
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity ----
    GO:0008134transcription factor binding IPI9722567
         
    FOXF2 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Foxf2):
     behavior/neurological  craniofacial  digestive/alimentary  growth/size  homeostasis/metabolism 
     mortality/aging  nervous system  respiratory system  skeleton  vision/eye 

    FOXF2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Foxf2tm1Miu for FOXF2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FOXF2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FOXF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FOXF2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FOXF2 

    10/482 SABiosciences Target genes for FOXF2 (see all 482):
    AACS ABCD3 ABHD3 ABI3BP ACOT6 ACTBL2 ACYP2 ADAMTS14 ADAMTS3 ADCY1

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOXF2
    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXF2 (see all 44):
    hsa-miR-3607-3p hsa-miR-302d hsa-miR-520e hsa-miR-300 hsa-miR-429 hsa-miR-4305 hsa-miR-301a hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidFOXF2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FOXF2
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of FOXF2

    Clone
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXF2
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                         Customized lentivirus expression plasmids for stable overexpression of FOXF2 

    Cell Line
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    LifeMap BioReagents: cell line associated with FOXF2: PureStem 7SMOO32, NCr-fac & Meso Progenitor
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXF2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FOXF2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for FOXF2 (Q129473 ENSP000002598064) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBPP202263, ENSP000002303544I2D: score=2 STRING: ENSP00000230354
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    GTF2BQ004033, ENSP000003595314I2D: score=2 STRING: ENSP00000359531
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001837epithelial to mesenchymal transition NAS19220249
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007389pattern specification process ----
    GO:0009790embryo development ----

    FOXF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FOXF2

    Search CenterWatch for drugs/clinical trials and news about FOXF2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FOXF2 gene: 
    NM_001452.1  

    Unigene Cluster for FOXF2:

    Forkhead box F2
    Hs.484423  [show with all ESTs]
    Unigene Representative Sequence: NM_001452
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000259806(uc003mtm.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOXF2
    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXF2 (see all 44):
    hsa-miR-3607-3p hsa-miR-302d hsa-miR-520e hsa-miR-300 hsa-miR-429 hsa-miR-4305 hsa-miR-301a hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidFOXF2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FOXF2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXF2
    Clone
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    GenScript: all cDNA clones in your preferred vector: FOXF2 (NM_001452)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXF2
    Sirion Biotech Customized lentivirus for stable overexpression of FOXF2 
                         Customized lentivirus expression plasmids for stable overexpression of FOXF2 
    Primer
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    OriGene qPCR primer pairs and template standards for FOXF2
    OriGene qSTAR qPCR primer pairs in human, mouse for FOXF2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FOXF2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXF2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXF2

    Additional mRNA sequence: U13220.1 

    2 DOTS entries:

    DT.100681796  DT.409187 

    24/29 AceView cDNA sequences (see all 29):

    BQ021409 W24258 BX363207 CD676558 NM_001452 CR607456 CA388621 BX384426 
    U13220 AI016883 AW337925 CB857371 BM989973 AW057861 BI257383 BM988565 
    CA448136 BG120697 BX108823 BM970095 AA340513 AI377768 BI335173 N33380 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FOXF2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for FOXF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FOXF2 expression in normal human tissues (normalized intensities)      FOXF2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FOXF2 Expression
    About this image


    FOXF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/29 selected tissues (see all 29) fully expand
     
     Fibroblast
             Detroit 551
             X-gene Foreskin Fibroblasts   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 5 entries
             Human Urothelial Cells (HUC)   
             visceral organ   
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 5 entries
             Mesencephalic Neural Crest Cells Prechordal Mesenchyme
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             Intervertebral Disc Annulus Fibrosus Cells Thoracic Intervertebral Disc
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             Human Tracheal Smooth Muscle Cells (HTSMC)   

    See FOXF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FOXF2

    SOURCE GeneReport for Unigene cluster: Hs.484423

    UniProtKB/Swiss-Prot: FOXF2_HUMAN, Q12947
    Tissue specificity: Lung and placenta

        SABiosciences Custom PCR Arrays for FOXF2
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FOXF2 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Foxf21 , 5 forkhead box F21, 5 88.91(n)1
    95.87(a)1
      13 (13.48 cM)5
    142381  NM_010225.21  NP_034355.21 
     316258165 
    chicken
    (Gallus gallus)
    Aves LOC1008577601 forkhead box protein F2-like 82.5(n)
    80.4(a)
      100857760  XM_003643493.1  XP_003643541.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    87(a)
    73(a)
    1 ↔ many
    1 ↔ many
    AAWZ02041218(3797-4099)
    GL343247.1(182954-203661)
    zebrafish
    (Danio rerio)
    Actinopterygii foxf2a1 forkhead box F2a 69.68(n)
    72.6(a)
      407681  NM_001083815.1  NP_001077284.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bin1 biniou 48.75(n)
    40.67(a)
      38766  NM_079226.2  NP_523950.2 
    worm
    (Caenorhabditis elegans)
    Secernentea let-3816
    Protein LET-381
    25(a)
    1 → many
    I(6320359-6323993)


    ENSEMBL Gene Tree for FOXF2 (if available)
    TreeFam Gene Tree for FOXF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FOXF2 gene
    FOXF12  FOXA22  FOXD4L12  FOXC22  FOXI22  FOXB12  FOXE32  FOXC12  
    FOXD4L22  FOXD4L32  FOXA32  FOXD4L52  FOXD12  FOXD32  FOXD4L42  FOXL12  
    FOXA12  FOXE12  FOXB22  FOXI12  FOXD4L62  FOXS12  FOXD22  FOXL22  
    FOXD42  
    1 SIMAP similar gene for FOXF2 using alignment to 1 protein entry:     FOXF2_HUMAN:
    FOXF1

    FOXF2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/174 SNPs in FOXF2 are shown (see all 174)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1122029101,2
    C,F--1388229(+) TCACTG/CTCTGG 1 -- us2k12Minor allele frequency- C:0.18NA 122
    rs1510779751,2
    --1388334(+) AGTCCC/TCCGGC 1 -- us2k10--------
    rs17119711,2
    C,F,H--1388422(+) TGTCTC/TCCTCC 1 -- us2k1 trp320Minor allele frequency- T:0.02NS EA NA WA CSA 1728
    rs1871478291,2
    --1388617(+) CGCCAA/GCTCCG 1 -- us2k10--------
    rs1140078681,2
    F--1388742(+) GGGCAC/TATCTC 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1410493371,2
    --1388808(+) TCTCGA/GACAGG 1 -- us2k10--------
    rs1502686671,2
    --1388898(+) TTCAGG/TACTGA 1 -- us2k10--------
    rs1995644431,2
    --1388979(+) CTTCC-/TTTT  
            
    TCTTT
    1 -- us2k10--------
    rs1919577591,2
    --1388997(+) CTTTTG/TTCTTA 1 -- us2k10--------
    rs1157068771,2
    C,F--1389091(+) AGTCTT/CTGAAA 1 -- us2k11Minor allele frequency- C:0.04WA 118

    HapMap Linkage Disequilibrium report for FOXF2 (1390069 - 1395832 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FOXF2:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv6424n71CNV Loss21882294
    nsv883369CNV Gain21882294
    nsv883370CNV Gain21882294


    Human Gene Mutation Database (HGMD): FOXF2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FOXF2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603250    OMIM disorders: --

    6 diseases for FOXF2:    About MalaCards
    blepharophimosis, ptosis, and epicanthus inversus syndrome    blepharophimosis    duane retraction syndrome    disorders of sex development
    cleft palate    prostatitis

    1 disease from the University of Copenhagen DISEASES database for FOXF2:
    Duane retraction syndrome

    FOXF2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FOXF2
    Human Genome Epidemiology (HuGE) Navigator: FOXF2 (1 document)

    Export disorders for FOXF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FOXF2 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with FOXF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The two-exon gene of the human forkhead transcription factor FREAC-2 (FKHL6) is located at 6p25.3. (PubMed id 9799607)1, 2, 3, 9 Blixt A.... Carlsson P. (1998)
    2. Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. (PubMed id 7957066)1, 2, 3 Pierrou S....Carlsson P. (1994)
    3. The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB. (PubMed id 9722567)1, 2, 9 Hellqvist M.... Carlsson P. (1998)
    4. Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2. (PubMed id 8626802)1, 2, 9 Hellqvist M.... Carlsson P. (1996)
    5. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    6. MicroRNA-182-5p promotes cell invasion and proliferati on by down regulating FOXF2, RECK and MTSS1 genes in human prostate cancer. (PubMed id 23383207)1 Hirata H....Dahiya R. (2013)
    7. The FOXF2 pathway in the human prostate stroma. (PubMed id 19562724)1 van der Heul-Nieuwenhuijsen L....Jenster G. (2009)
    8. Gene expression of forkhead transcription factors in the normal and diseased human prostate. (PubMed id 19220249)1 van der Heul-Nieuwenhuijsen L....Jenster G. (2009)
    9. Genome-wide association identifies the ABO blood grou p as a major locus associated with serum levels of soluble E-selectin. (PubMed id 19729612)4 Paterson A.D....Bull S.B. (2009)
    10. Mutation analysis of FOXF2 in patients with disorders of sex development (DSD) in combination with cleft palate. (PubMed id 19276632)1 Jochumsen U....Holterhus P.M. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2295 HGNC: 3810 AceView: FOXF2 Ensembl:ENSG00000137273 euGenes: HUgn2295
    ECgene: FOXF2 H-InvDB: FOXF2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FOXF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FOXF2 gene:
    Search GeneIP for patents involving FOXF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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