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Aliases for FOXF2 Gene

Aliases for FOXF2 Gene

  • Forkhead Box F2 2 3 5
  • Forkhead-Related Transcription Factor 2 3 4
  • Forkhead-Related Protein FKHL6 3 4
  • Forkhead-Related Activator 2 3 4
  • FREAC-2 3 4
  • FREAC2 3 4
  • FKHL6 3 4
  • Forkhead Box Protein F2 3
  • Forkhead-Like 6 3

External Ids for FOXF2 Gene

Previous HGNC Symbols for FOXF2 Gene

  • FKHL6

Previous GeneCards Identifiers for FOXF2 Gene

  • GC06P001375
  • GC06P001335

Summaries for FOXF2 Gene

Entrez Gene Summary for FOXF2 Gene

  • FOXF2 encodes forkhead box F2, one of many human homologues of the Drosophila melanogaster transcription factor forkhead. FOXF2 is expressed in lung and placenta, and has been shown to transcriptionally activate several lung-specific genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXF2 Gene

FOXF2 (Forkhead Box F2) is a Protein Coding gene. Diseases associated with FOXF2 include Duane Retraction Syndrome 1. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is FOXF1.

UniProtKB/Swiss-Prot for FOXF2 Gene

  • Probable transcription activator for a number of lung-specific genes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXF2 Gene

Genomics for FOXF2 Gene

Regulatory Elements for FOXF2 Gene

Enhancers for FOXF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F001381 1.4 FANTOM5 ENCODE 2.7 -0.4 -384 15.6 PKNOX1 SIN3A FEZF1 ZNF2 ZNF302 CBX5 ZNF143 FOS DEK ZNF263 FOXF2 GC06M001386 LOC105374880
GH06F001414 0.3 FANTOM5 12.2 +25.0 25025 0.3 FOXF2 GC06M001405 GC06M001423
GH06F001198 0.6 ENCODE 4.9 -189.1 -189058 3.7 HMG20B TAF1 CEBPB EP300 DNMT3B TCF7L2 TEAD3 FOXQ1 FOXF2 GC06P001197 GC06P001205
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FOXF2 on UCSC Golden Path with GeneCards custom track

Promoters for FOXF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001877377 66 2201 KLF17 BRCA1 ZNF2 ZNF335 GLIS2 ZNF366 KLF7 ZNF263 SP3 CEBPB

Genomic Location for FOXF2 Gene

Chromosome:
6
Start:
1,389,834 bp from pter
End:
1,395,597 bp from pter
Size:
5,764 bases
Orientation:
Plus strand

Genomic View for FOXF2 Gene

Genes around FOXF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXF2 Gene

Proteins for FOXF2 Gene

  • Protein details for FOXF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12947-FOXF2_HUMAN
    Recommended name:
    Forkhead box protein F2
    Protein Accession:
    Q12947
    Secondary Accessions:
    • Q5TGJ1
    • Q9UQ85

    Protein attributes for FOXF2 Gene

    Size:
    444 amino acids
    Molecular mass:
    45993 Da
    Quaternary structure:
    • Interacts with the transcription factors TBP and TFIIB.

neXtProt entry for FOXF2 Gene

Post-translational modifications for FOXF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for FOXF2
  • Santa Cruz Biotechnology (SCBT) Antibodies for FOXF2

No data available for DME Specific Peptides for FOXF2 Gene

Domains & Families for FOXF2 Gene

Gene Families for FOXF2 Gene

Protein Domains for FOXF2 Gene

Suggested Antigen Peptide Sequences for FOXF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12947

UniProtKB/Swiss-Prot:

FOXF2_HUMAN :
  • Two activation domains, AD1 and AD2, C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation.
Domain:
  • Two activation domains, AD1 and AD2, C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation.
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXF2: view

Function for FOXF2 Gene

Molecular function for FOXF2 Gene

GENATLAS Biochemistry:
transcription factor-like 6,with a Drosophila homeo forkhead DNA binding domain homolog,expressed in lung and placenta
UniProtKB/Swiss-Prot Function:
Probable transcription activator for a number of lung-specific genes.

Gene Ontology (GO) - Molecular Function for FOXF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 8626802
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IMP 8626802
GO:0003677 DNA binding IDA 7957066
GO:0003700 transcription factor activity, sequence-specific DNA binding IDA 9722567
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IBA --
genes like me logo Genes that share ontologies with FOXF2: view
genes like me logo Genes that share phenotypes with FOXF2: view

Animal Models for FOXF2 Gene

MGI Knock Outs for FOXF2:

Animal Model Products

Transcription Factor Targets for FOXF2 Gene

Selected GeneGlobe predicted Target genes for FOXF2

Inhibitory RNA Products

Clone Products

Cell Line Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for FOXF2 Gene

Localization for FOXF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXF2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXF2 gene
Compartment Confidence
nucleus 5
extracellular 1

Gene Ontology (GO) - Cellular Components for FOXF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 9722567
GO:0005667 transcription factor complex IDA 9722567
genes like me logo Genes that share ontologies with FOXF2: view

Pathways & Interactions for FOXF2 Gene

SuperPathways for FOXF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001837 epithelial to mesenchymal transition NAS 19220249
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0030198 extracellular matrix organization IEA --
genes like me logo Genes that share ontologies with FOXF2: view

No data available for Pathways by source and SIGNOR curated interactions for FOXF2 Gene

Transcripts for FOXF2 Gene

mRNA/cDNA for FOXF2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXF2 Gene

Forkhead box F2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXF2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c
SP1:
SP2: -

Relevant External Links for FOXF2 Gene

GeneLoc Exon Structure for
FOXF2
ECgene alternative splicing isoforms for
FOXF2

Expression for FOXF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FOXF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXF2 Gene

This gene is overexpressed in Esophagus - Muscularis (x12.4), Esophagus - Gastroesophageal Junction (x11.3), and Colon - Sigmoid (x4.9).

Protein differential expression in normal tissues from HIPED for FOXF2 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FOXF2 Gene



Protein tissue co-expression partners for FOXF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FOXF2 Gene:

FOXF2

SOURCE GeneReport for Unigene cluster for FOXF2 Gene:

Hs.484423

mRNA Expression by UniProt/SwissProt for FOXF2 Gene:

Q12947-FOXF2_HUMAN
Tissue specificity: Lung and placenta.
genes like me logo Genes that share expression patterns with FOXF2: view

Primer Products

Orthologs for FOXF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FOXF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXF2 34 35
  • 97.96 (n)
cow
(Bos Taurus)
Mammalia FOXF2 34 35
  • 90.31 (n)
dog
(Canis familiaris)
Mammalia FOXF2 34 35
  • 86.42 (n)
mouse
(Mus musculus)
Mammalia Foxf2 34 16 35
  • 84.44 (n)
oppossum
(Monodelphis domestica)
Mammalia FOXF2 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOXF2 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857760 34
  • 84.36 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 87 (a)
OneToMany
-- 35
  • 75 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia foxf2 34
  • 76.77 (n)
zebrafish
(Danio rerio)
Actinopterygii foxf2a 34 35
  • 72.2 (n)
foxf2b 35
  • 58 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1195 34
Species where no ortholog for FOXF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXF2 Gene

ENSEMBL:
Gene Tree for FOXF2 (if available)
TreeFam:
Gene Tree for FOXF2 (if available)

Paralogs for FOXF2 Gene

(1) SIMAP similar genes for FOXF2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXF2: view

Variants for FOXF2 Gene

Sequence variations from dbSNP and Humsavar for FOXF2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs587777898 untested 1,390,846(+) TGCGG(C/G)CGGGG upstream-variant-2KB, reference, missense
rs111257067 -- 1,390,861(+) GGCGG(-/CGG)CGGCG upstream-variant-2KB, cds-indel
rs111582458 -- 1,391,303(+) CTGTC(C/T)TCCCA intron-variant, upstream-variant-2KB
rs111748399 -- 1,395,959(+) TGCCC(A/G)GGGAG downstream-variant-500B
rs111952129 -- 1,388,854(+) AGAGT(C/G)TTTGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FOXF2 Gene

Variant ID Type Subtype PubMed ID
nsv950756 CNV deletion 24416366
nsv1133624 CNV deletion 24896259
nsv1073528 CNV deletion 25765185
nsv1017614 CNV loss 25217958
esv3576090 CNV gain 25503493

Variation tolerance for FOXF2 Gene

Residual Variation Intolerance Score: 36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.06; 95.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXF2 Gene

Human Gene Mutation Database (HGMD)
FOXF2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXF2 Gene

Disorders for FOXF2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FOXF2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
duane retraction syndrome 1
  • duane retraction syndrome
- elite association - COSMIC cancer census association via MalaCards
Search FOXF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FOXF2

Genetic Association Database (GAD)
FOXF2
Human Genome Epidemiology (HuGE) Navigator
FOXF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXF2
genes like me logo Genes that share disorders with FOXF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOXF2 Gene

Publications for FOXF2 Gene

  1. The two-exon gene of the human forkhead transcription factor FREAC-2 (FKHL6) is located at 6p25.3. (PMID: 9799607) Blixt A. … Carlsson P. (Genomics 1998) 2 3 4 22 64
  2. The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB. (PMID: 9722567) Hellqvist M. … Carlsson P. (J. Biol. Chem. 1998) 3 4 22 64
  3. Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2. (PMID: 8626802) Hellqvist M. … Carlsson P. (J. Biol. Chem. 1996) 3 4 22 64
  4. Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. (PMID: 7957066) Pierrou S. … Carlsson P. (EMBO J. 1994) 2 3 4 64
  5. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 46 64

Products for FOXF2 Gene

Sources for FOXF2 Gene

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