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Aliases for FOXF2 Gene

Aliases for FOXF2 Gene

  • Forkhead Box F2 2 3
  • Forkhead-Related Transcription Factor 2 3 4
  • Forkhead-Related Protein FKHL6 3 4
  • Forkhead-Related Activator 2 3 4
  • FREAC-2 3 4
  • FREAC2 3 4
  • FKHL6 3 4
  • Forkhead-Like 6 3

External Ids for FOXF2 Gene

Previous HGNC Symbols for FOXF2 Gene

  • FKHL6

Previous GeneCards Identifiers for FOXF2 Gene

  • GC06P001375
  • GC06P001335

Summaries for FOXF2 Gene

Entrez Gene Summary for FOXF2 Gene

  • FOXF2 encodes forkhead box F2, one of many human homologues of the Drosophila melanogaster transcription factor forkhead. FOXF2 is expressed in lung and placenta, and has been shown to transcriptionally activate several lung-specific genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXF2 Gene

FOXF2 (Forkhead Box F2) is a Protein Coding gene. Diseases associated with FOXF2 include 3-m syndrome 1 and axenfeld-rieger syndrome, type 3. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is FOXK2.

UniProtKB/Swiss-Prot for FOXF2 Gene

  • Probable transcription activator for a number of lung-specific genes

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXF2 Gene

Genomics for FOXF2 Gene

Regulatory Elements for FOXF2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FOXF2 Gene

Chromosome:
6
Start:
1,389,834 bp from pter
End:
1,395,597 bp from pter
Size:
5,764 bases
Orientation:
Plus strand

Genomic View for FOXF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXF2 Gene

Proteins for FOXF2 Gene

  • Protein details for FOXF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12947-FOXF2_HUMAN
    Recommended name:
    Forkhead box protein F2
    Protein Accession:
    Q12947
    Secondary Accessions:
    • Q5TGJ1
    • Q9UQ85

    Protein attributes for FOXF2 Gene

    Size:
    444 amino acids
    Molecular mass:
    45993 Da
    Quaternary structure:
    • Interacts with the transcription factors TBP and TFIIB.

neXtProt entry for FOXF2 Gene

Proteomics data for FOXF2 Gene at MOPED

Post-translational modifications for FOXF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FOXF2 Gene

Domains & Families for FOXF2 Gene

Gene Families for FOXF2 Gene

Protein Domains for FOXF2 Gene

Suggested Antigen Peptide Sequences for FOXF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12947

UniProtKB/Swiss-Prot:

FOXF2_HUMAN :
  • Two activation domains, AD1 and AD2, C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation.
Domain:
  • Two activation domains, AD1 and AD2, C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation.
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXF2: view

Function for FOXF2 Gene

Molecular function for FOXF2 Gene

GENATLAS Biochemistry:
transcription factor-like 6,with a Drosophila homeo forkhead DNA binding domain homolog,expressed in lung and placenta
UniProtKB/Swiss-Prot Function:
Probable transcription activator for a number of lung-specific genes

Gene Ontology (GO) - Molecular Function for FOXF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 8626802
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IMP 8626802
GO:0003677 DNA binding IDA 7957066
GO:0003700 transcription factor activity, sequence-specific DNA binding IDA 9722567
GO:0008134 transcription factor binding IPI 9722567
genes like me logo Genes that share ontologies with FOXF2: view
genes like me logo Genes that share phenotypes with FOXF2: view

Animal Models for FOXF2 Gene

MGI Knock Outs for FOXF2:

Animal Model Products

Transcription Factor Targets for FOXF2 Gene

Selected GeneGlobe predicted Target genes for FOXF2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOXF2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for FOXF2 Gene

Localization for FOXF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXF2 Gene COMPARTMENTS Subcellular localization image for FOXF2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for FOXF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9722567
GO:0005667 transcription factor complex IDA 9722567
genes like me logo Genes that share ontologies with FOXF2: view

Pathways & Interactions for FOXF2 Gene

SuperPathways for FOXF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001837 epithelial to mesenchymal transition NAS 19220249
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IDA 8626802
GO:0030198 extracellular matrix organization IEA --
GO:0042249 establishment of planar polarity of embryonic epithelium IEA --
genes like me logo Genes that share ontologies with FOXF2: view

No data available for Pathways by source and SIGNOR curated interactions for FOXF2 Gene

Drugs & Compounds for FOXF2 Gene

No Compound Related Data Available

Transcripts for FOXF2 Gene

mRNA/cDNA for FOXF2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXF2 Gene

Forkhead box F2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOXF2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXF2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c
SP1:
SP2: -

Relevant External Links for FOXF2 Gene

GeneLoc Exon Structure for
FOXF2
ECgene alternative splicing isoforms for
FOXF2

Expression for FOXF2 Gene

mRNA expression in normal human tissues for FOXF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXF2 Gene

This gene is overexpressed in Esophagus - Muscularis (x12.4), Esophagus - Gastroesophageal Junction (x11.3), and Colon - Sigmoid (x4.9).

Protein differential expression in normal tissues from HIPED for FOXF2 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FOXF2 Gene



SOURCE GeneReport for Unigene cluster for FOXF2 Gene Hs.484423

mRNA Expression by UniProt/SwissProt for FOXF2 Gene

Q12947-FOXF2_HUMAN
Tissue specificity: Lung and placenta
genes like me logo Genes that share expression patterns with FOXF2: view

Protein tissue co-expression partners for FOXF2 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for FOXF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FOXF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOXF2 35
  • 90.31 (n)
  • 93.9 (a)
FOXF2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXF2 35
  • 86.42 (n)
  • 83.99 (a)
FOXF2 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxf2 35
  • 84.44 (n)
  • 88.56 (a)
Foxf2 16
Foxf2 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FOXF2 35
  • 97.96 (n)
  • 97.73 (a)
FOXF2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FOXF2 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOXF2 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857760 35
  • 84.36 (n)
  • 84.23 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 87 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia foxf2 35
  • 76.77 (n)
  • 87.19 (a)
zebrafish
(Danio rerio)
Actinopterygii foxf2a 35
  • 72.2 (n)
  • 76.8 (a)
foxf2a 36
  • 70 (a)
OneToMany
foxf2b 36
  • 58 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1195 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToMany
Species with no ortholog for FOXF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXF2 Gene

ENSEMBL:
Gene Tree for FOXF2 (if available)
TreeFam:
Gene Tree for FOXF2 (if available)

Paralogs for FOXF2 Gene

(1) SIMAP similar genes for FOXF2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXF2: view

Variants for FOXF2 Gene

Sequence variations from dbSNP and Humsavar for FOXF2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs732835 -- 1,392,765(+) TGGAG(C/G)GGGTG intron-variant
rs910022 -- 1,393,655(+) CGTGG(G/T)TACGG intron-variant
rs910023 -- 1,393,950(+) GGTCC(A/G)GGCCT intron-variant
rs938723 -- 1,392,856(-) TCGGG(G/T)GTTCT intron-variant
rs1737762 -- 1,395,878(+) TAGAA(A/G)GAAAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FOXF2 Gene

Variant ID Type Subtype PubMed ID
nsv883369 CNV Gain 21882294
nsv883370 CNV Gain 21882294
dgv6424n71 CNV Loss 21882294

Variation tolerance for FOXF2 Gene

Residual Variation Intolerance Score: 36.03% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.06; 95.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXF2 Gene

HapMap Linkage Disequilibrium report
FOXF2
Human Gene Mutation Database (HGMD)
FOXF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXF2 Gene

Disorders for FOXF2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FOXF2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
3-m syndrome 1
  • 3-m syndrome
axenfeld-rieger syndrome, type 3
  • rieger or axenfeld anomalies
persistent hyperplastic primary vitreous
  • phpv
- elite association
Search FOXF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FOXF2

Genetic Association Database (GAD)
FOXF2
Human Genome Epidemiology (HuGE) Navigator
FOXF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXF2
genes like me logo Genes that share disorders with FOXF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOXF2 Gene

Publications for FOXF2 Gene

  1. The two-exon gene of the human forkhead transcription factor FREAC-2 (FKHL6) is located at 6p25.3. (PMID: 9799607) Blixt A. … Carlsson P. (Genomics 1998) 2 23 67
  2. FOXL2 mutations in Taiwanese patients with blepharophimosis, ptosis, epicanthus inversus syndrome. (PMID: 20184535) Lin W.D. … Tsai F.J. (Clin. Chem. Lab. Med. 2010) 23 67
  3. FOXL2 gene mutations and blepharophimosis-ptosis-epicanthus inversus syndrome (BPES): a novel mutation detected in a Chinese family and a statistic model for summarizing previous reported records. (PMID: 19592504) Xu Y. … Yan X. (Mutagenesis 2009) 23 67
  4. [Mutation analysis of FOXL2 gene and its structure protein in patients of blepharophimosis-ptosis-epicanthus inversus syndrome]. (PMID: 17897532) Lin L.X. … Wang Y.L. (Zhonghua Yan Ke Za Zhi 2007) 23 67
  5. A novel insertion mutation in the FOXL2 gene is detected in a big Chinese family with blepharophimosis-ptosis-epicanthus inversus. (PMID: 15450400) Qian X. … He L. (Mutat. Res. 2004) 23 67

Products for FOXF2 Gene

Sources for FOXF2 Gene

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