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FOXF2 Gene

protein-coding   GIFtS: 53
GCID: GC06P001390

Forkhead Box F2


(Previous symbol: FKHL6)
  See FOXF2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Forkhead Box F21 2     Forkhead-Related Transcription Factor 22 3
FKHL61 2 3 5     FREAC-22 3
FREAC22 3 5     Forkhead Box Protein F22
Forkhead-Related Activator 22 3     Forkhead-Like 62
Forkhead-Related Protein FKHL62 3     

External Ids:    HGNC: 38101   Entrez Gene: 22952   Ensembl: ENSG000001372737   OMIM: 6032505   UniProtKB: Q129473   

Export aliases for FOXF2 gene to outside databases

Previous GC identifers: GC06P001375 GC06P001335


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FOXF2 Gene:
FOXF2 encodes forkhead box F2, one of many human homologues of the Drosophila melanogaster transcription factor
forkhead. FOXF2 is expressed in lung and placenta, and has been shown to transcriptionally activate several
lung-specific genes. (provided by RefSeq, Jul 2008)

GeneCards Summary for FOXF2 Gene:
FOXF2 (forkhead box F2) is a protein-coding gene. Diseases associated with FOXF2 include duane retraction syndrome, and blepharophimosis. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOXF1.

UniProtKB/Swiss-Prot: FOXF2_HUMAN, Q12947
Function: Probable transcription activator for a number of lung-specific genes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the FOXF2 gene promoter:
         GATA-1   C/EBPalpha   E47   CHOP-10   Pax-3   FOXO1a   Hand1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOXF2 promoter sequence
   Search Chromatin IP Primers for FOXF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FOXF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25.3   Ensembl cytogenetic band:  6p25.3   HGNC cytogenetic band: 6p25.3

FOXF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXF2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P001390:  view genomic region     (about GC identifiers)

Start:
1,390,069 bp from pter      End:
1,395,832 bp from pter
Size:
5,764 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FOXF2_HUMAN, Q12947 (See protein sequence)
Recommended Name: Forkhead box protein F2  
Size: 444 amino acids; 45993 Da
Subunit: Interacts with the transcription factors TBP and TFIIB
Secondary accessions: Q5TGJ1 Q9UQ85

Explore the universe of human proteins at neXtProt for FOXF2: NX_Q12947

Explore proteomics data for FOXF2 at MOPED


See FOXF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001443.1  
ENSEMBL proteins: 
 ENSP00000259806  

FOXF2 Human Recombinant Protein Products:

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LSBio Antibodies in human, mouse, rat for FOXF2

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
FOX: Forkhead boxes

3 InterPro protein domains:
 IPR011991 WHTH_DNA-bd_dom
 IPR018122 TF_fork_head_CS
 IPR001766 TF_fork_head

Graphical View of Domain Structure for InterPro Entry Q12947

ProtoNet protein and cluster: Q12947

UniProtKB/Swiss-Prot: FOXF2_HUMAN, Q12947
Domain: Two activation domains, AD1 and AD2, C-terminal of (and distinct from) the forkhead domains are necessary
for transcriptional activation
Similarity: Contains 1 fork-head DNA-binding domain


Find genes that share domains with FOXF2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: FOXF2_HUMAN, Q12947
Function: Probable transcription activator for a number of lung-specific genes

     Genatlas biochemistry entry for FOXF2:
transcription factor-like 6,with a Drosophila homeo forkhead DNA binding domain homolog,expressed in lung and
placenta

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IDA7957066
GO:0003700sequence-specific DNA binding transcription factor activity IDA9722567
GO:0008134transcription factor binding IPI9722567
GO:0043565sequence-specific DNA binding IDA7957066
     
Find genes that share ontologies with FOXF2           About GenesLikeMe


Phenotypes:
     11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Foxf2):
 behavior/neurological  craniofacial  digestive/alimentary  growth/size/body  homeostasis/metabolism 
 mortality/aging  nervous system  no phenotypic analysis  respiratory system  skeleton 
 vision/eye 

Find genes that share phenotypes with FOXF2           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Foxf2tm1Miu for FOXF2

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FOXF2
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FOXF2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FOXF2
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FOXF2

miRNA
Products:
    
miRTarBase miRNAs that target FOXF2:
hsa-mir-182-5p (MIRT007330), hsa-mir-124-3p (MIRT022115), hsa-mir-26b-5p (MIRT028797)

Block miRNA regulation of human, mouse, rat FOXF2 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate FOXF2 (see all 44):
hsa-miR-3607-3p hsa-miR-302d hsa-miR-520e hsa-miR-300 hsa-miR-429 hsa-miR-4305 hsa-miR-301a hsa-miR-519a
SwitchGear 3'UTR luciferase reporter plasmidFOXF2 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat FOXF2

Gene Editing
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXF2

Cell Line
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ESI BIO PureStem Progenitor for FOXF2: 
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXF2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
FOXF2_HUMAN, Q12947: Nucleus
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA9722567
GO:0005667transcription factor complex IDA9722567

Find genes that share ontologies with FOXF2           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FOXF2
Interactions:

    GeneGlobe Interaction Network for FOXF2

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

Selected Interacting proteins for FOXF2 (Q129473 ENSP000002598064) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
InteractantInteraction Details
GeneCardExternal ID(s)
TBPP202263, ENSP000002303544I2D: score=2 STRING: ENSP00000230354
ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
GTF2BQ004033, ENSP000003595314I2D: score=2 STRING: ENSP00000359531
NFIL3ENSP000002976894STRING: ENSP00000297689
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Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001837epithelial to mesenchymal transition NAS19220249
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated ----
GO:0030198extracellular matrix organization IEA--
GO:0042249establishment of planar polarity of embryonic epithelium IEA--

Find genes that share ontologies with FOXF2           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for FOXF2



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for FOXF2 gene: 
NM_001452.1  

Unigene Cluster for FOXF2:

Forkhead box F2
Hs.484423  [show with all ESTs]
Unigene Representative Sequence: NM_001452
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000259806(uc003mtm.3)
miRNA
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Block miRNA regulation of human, mouse, rat FOXF2 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate FOXF2 (see all 44):
hsa-miR-3607-3p hsa-miR-302d hsa-miR-520e hsa-miR-300 hsa-miR-429 hsa-miR-4305 hsa-miR-301a hsa-miR-519a
SwitchGear 3'UTR luciferase reporter plasmidFOXF2 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for FOXF2
Predesigned siRNA for gene silencing in human, mouse, rat FOXF2
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OriGene ORF clones in mouse, rat for FOXF2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: FOXF2 (NM_001452)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXF2
Primer
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OriGene qPCR primer pairs and template standards for FOXF2
OriGene qSTAR qPCR primer pairs in human, mouse for FOXF2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FOXF2
  QuantiTect SYBR Green Assays in human, mouse, rat FOXF2
  QuantiFast Probe-based Assays in human, mouse, rat FOXF2

Additional mRNA sequence: U13220.1 

2 DOTS entries:

DT.100681796  DT.409187 

Selected AceView cDNA sequences (see all 29):

W24258 BQ021409 CR607456 BX384426 BX363207 CA388621 NM_001452 U13220 
CD676558 AA340513 CA448136 BG120697 AW337925 BM988565 AW057861 BI257383 
CB857371 BX108823 AI016883 BM970095 AI377768 BM989973 N33380 BI335173 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for FOXF2    About this scheme

ExUns: 1a · 1b ^ 2a · 2b · 2c
SP1:                              
SP2:              -               


ECgene alternative splicing isoforms for FOXF2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FOXF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
FOXF2 Expression
About this image


FOXF2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 12) fully expand
 
 Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
         PureStem 7SMOO32, NCr-fac & Meso Progenitor
 
 Mesoderm (Gastrulation Derivatives)
         PureStem 7SMOO32, NCr-fac & Meso Progenitor
 
 Endothelium (Cardiovascular System)    fully expand to see all 3 entries
         Adult Endothelial Cells Blood Brain Barrier
 
 Brain (Nervous System)    fully expand to see all 3 entries
         Adult Endothelial Cells Blood Brain Barrier
 
 Gut Tube (Gastrointestinal Tract)
         Foregut
FOXF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

FOXF2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.484423

UniProtKB/Swiss-Prot: FOXF2_HUMAN, Q12947
Tissue specificity: Lung and placenta

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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for FOXF2 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Foxf21 , 5 forkhead box F21, 5 84.44(n)1
88.56(a)1
  13 (13.48 cM)5
142381  NM_010225.21  NP_034355.21 
 316258165 
chicken
(Gallus gallus)
Aves LOC1008577601 forkhead box protein F2-like 84.36(n)
84.23(a)
  100857760  XM_003643493.2  XP_003643541.2 
lizard
(Anolis carolinensis)
Reptilia --
--
--
87(a)
75(a)
1 ↔ many
1 ↔ many
AAWZ02041218(3797-4099)
GL343247.1(182954-203661)
tropical clawed frog
(Xenopus tropicalis)
Amphibia foxf21 forkhead box F2 76.77(n)
87.19(a)
  100101712  NM_001100232.1  NP_001093702.1 
zebrafish
(Danio rerio)
Actinopterygii foxf2a1 forkhead box F2a 72.2(n)
76.8(a)
  407681  NM_001083815.1  NP_001077284.1 


ENSEMBL Gene Tree for FOXF2 (if available)
TreeFam Gene Tree for FOXF2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for FOXF2 gene
FOXF12  FOXQ12  FOXN32  FOXJ12  FOXK12  FOXN42  FOXR12  FOXH12  
FOXK22  FOXN12  FOXJ32  FOXG12  FOXJ22  FOXN22  FOXR22  
1 SIMAP similar gene for FOXF2 using alignment to 1 protein entry:     FOXF2_HUMAN:
FOXF1

Find genes that share paralogs with FOXF2           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FOXF2 (see all 174)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1122029101,2
C,F--1388229(+) TCACTG/CTCTGG 1 -- us2k12Minor allele frequency- C:0.18NA 122
rs1510779751,2
--1388334(+) AGTCCC/TCCGGC 1 -- us2k10--------
rs17119711,2
C,F,H--1388422(+) TGTCTC/TCCTCC 1 -- us2k1 trp320Minor allele frequency- T:0.02NS EA NA WA CSA 1728
rs1871478291,2
--1388617(+) CGCCAA/GCTCCG 1 -- us2k10--------
rs1140078681,2
F--1388742(+) GGGCAC/TATCTC 1 -- us2k11Minor allele frequency- T:0.01NA 120
rs1410493371,2
--1388808(+) TCTCGA/GACAGG 1 -- us2k10--------
rs1502686671,2
--1388898(+) TTCAGG/TACTGA 1 -- us2k10--------
rs1995644431,2
--1388979(+) CTTCC-/TTTT  
        
TCTTT
1 -- us2k10--------
rs1919577591,2
--1388997(+) CTTTTG/TTCTTA 1 -- us2k10--------
rs1157068771,2
C,F--1389091(+) AGTCTT/CTGAAA 1 -- us2k11Minor allele frequency- C:0.04WA 118

HapMap Linkage Disequilibrium report for FOXF2 (1390069 - 1395832 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for FOXF2:    About this table    
Variant IDTypeSubtypePubMed ID
dgv6424n71CNV Loss21882294
nsv883369CNV Gain21882294
nsv883370CNV Gain21882294

Human Gene Mutation Database (HGMD): FOXF2
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing FOXF2
DNA2.0 Custom Variant and Variant Library Synthesis for FOXF2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 603250    OMIM disorders: --

2 diseases for FOXF2:    
About MalaCards
duane retraction syndrome    blepharophimosis

1 disease from the University of Copenhagen DISEASES database for FOXF2:
Duane retraction syndrome

Find genes that share disorders with FOXF2           About GenesLikeMe

Genetic Association Database (GAD): FOXF2
Human Genome Epidemiology (HuGE) Navigator: FOXF2 (1 document)

Export disorders for FOXF2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FOXF2 gene, integrated from 10 sources (see all 21):
(articles sorted by number of sources associating them with FOXF2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The two-exon gene of the human forkhead transcription factor FREAC-2 (FKHL6) is located at 6p25.3. (PubMed id 9799607)1, 2, 3, 9 Blixt A.... Carlsson P. (Genomics 1998)
  2. Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. (PubMed id 7957066)1, 2, 3 Pierrou S.... Carlsson P. (EMBO J. 1994)
  3. The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB. (PubMed id 9722567)1, 2, 9 Hellqvist M.... Carlsson P. (J. Biol. Chem. 1998)
  4. Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2. (PubMed id 8626802)1, 2, 9 Hellqvist M.... Carlsson P. (J. Biol. Chem. 1996)
  5. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
  6. Decreased FOXF2 mRNA expression indicates early-onset metastasis and poor prognosis for breast cancer patients with histological grade II tumor. (PubMed id 23620774)1 Kong P.Z....Feng Y.M. (PLoS ONE 2013)
  7. MicroRNA-182-5p promotes cell invasion and proliferation by down regulating FOXF2, RECK and MTSS1 genes in human prostate cancer. (PubMed id 23383207)1 Hirata H....Dahiya R. (PLoS ONE 2013)
  8. The FOXF2 pathway in the human prostate stroma. (PubMed id 19562724)1 van der Heul-Nieuwenhuijsen L....Jenster G. (Prostate 2009)
  9. Gene expression of forkhead transcription factors in the normal and diseased human prostate. (PubMed id 19220249)1 van der Heul-Nieuwenhuijsen L....Jenster G. (BJU Int. 2009)
  10. Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin. (PubMed id 19729612)4 Paterson A.D....Bull S.B. (Arterioscler. Thromb. Vasc. Biol. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2295 HGNC: 3810 AceView: FOXF2 Ensembl:ENSG00000137273 euGenes: HUgn2295
ECgene: FOXF2 H-InvDB: FOXF2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FOXF2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for FOXF2 gene:
Search GeneIP for patents involving FOXF2

GeneCards and IP:
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