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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FOXF1 Gene

protein-coding   GIFtS: 59
GCID: GC16P086544

Forkhead Box F1


(Previous symbol: FKHL5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Forkhead Box F11 2     FREAC-12 3
FKHL51 2 3 5     FREAC12 3
Forkhead-Related Activator 12 3     ACDMPV2 5
Forkhead-Related Protein FKHL52 3     Forkhead Box Protein F12
Forkhead-Related Transcription Factor 12 3     Forkhead, Drosophila, Homolog-Like 52

External Ids:    HGNC: 38091   Entrez Gene: 22942   Ensembl: ENSG000001032417   OMIM: 6010895   UniProtKB: Q129463   

Export aliases for FOXF1 gene to outside databases

Previous GC identifers: GC16P077898 GC16P087577 GC16P086284 GC16P086325 GC16P085101 GC16P072284


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FOXF1 Gene:
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead
domain. The specific function of this gene has not yet been determined; however, it may play a role in the
regulation of pulmonary genes as well as embryonic development. (provided by RefSeq, Jul 2008)

GeneCards Summary for FOXF1 Gene: 
FOXF1 (forkhead box F1) is a protein-coding gene. Diseases associated with FOXF1 include nonspecific interstitial pneumonia, and alveolar capillary dysplasia with misalignment of pulmonary veins. GO annotations related to this gene include sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is FOXA2.

UniProtKB/Swiss-Prot: FOXF1_HUMAN, Q12946
Function: Probable transcription activator for a number of lung-specific genes

Gene Wiki entry for FOXF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FOXF1 gene promoter:
         E2F   p53   FOXO4   STAT3   MyoD   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOXF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FOXF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24   Ensembl cytogenetic band:  16q24.1   HGNC cytogenetic band: 16q24

FOXF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXF1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P086544:  view genomic region     (about GC identifiers)

Start:
86,544,133 bp from pter      End:
86,548,076 bp from pter
Size:
3,944 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FOXF1_HUMAN, Q12946 (See protein sequence)
Recommended Name: Forkhead box protein F1  
Size: 379 amino acids; 40122 Da
Subcellular location: Nucleus (Probable)
Developmental stage: Expressed in fetal lung
Caution: It is uncertain whether Met-1 or Met-26 is the initiator
Sequence caution: Sequence=AAC50399.1; Type=Erroneous initiation; Sequence=AAC61576.1; Type=Erroneous initiation;
Sequence=AAH89442.1; Type=Erroneous initiation; Sequence=BAG36851.1; Type=Frameshift; Positions=Several;
Secondary accessions: B2RAF4 Q5FWE5

Explore the universe of human proteins at neXtProt for FOXF1: NX_Q12946

Explore proteomics data for FOXF1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q12946

  • FOXF1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FOXF1 Protein Expression
    REFSEQ proteins: NP_001442.2  
    ENSEMBL proteins: 
     ENSP00000262426  

    Human Recombinant Protein Products for FOXF1: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FOXF1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IC9769171
    GO:0005667transcription factor complex IBA--

    FOXF1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FOX: Forkhead boxes

    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry Q12946

    ProtoNet protein and cluster: Q12946

    UniProtKB/Swiss-Prot: FOXF1_HUMAN, Q12946
    Domain: Activation domains C-terminal of (and distinct from) the forkhead domains are necessary for
    transcriptional activation
    Similarity: Contains 1 fork-head DNA-binding domain


    FOXF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOXF1_HUMAN, Q12946
    Function: Probable transcription activator for a number of lung-specific genes

         Genatlas biochemistry entry for FOXF1:
    transcription factor-like 5,with a Drosophila homeo fork head DNA binding domain homolog,containing a CGG repeat
    in 5'utr

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA9769171
    GO:0003690double-stranded DNA binding IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IBA--
    GO:0008134transcription factor binding IBA--
         
    FOXF1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FOXF1:
     Decreased circadian period len 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Foxf1):
     cardiovascular system  digestive/alimentary  embryogenesis  mortality/aging  respiratory system 

    FOXF1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Foxf1tm1Pca for FOXF1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FOXF1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FOXF1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FOXF1 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidFOXF1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXF1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FOXF1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Selected targets of C/EBPbeta
    Selected targets of C/EBPbeta
    2FOXA2 and FOXA3 transcription factor networks
    FOXA2 and FOXA3 transcription factor networks

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for FOXF1
        Selected targets of C/EBPbeta


    1 BioSystems Pathway for FOXF1
        FOXA2 and FOXA3 transcription factor networks



    FOXF1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOXF1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FOXF1 (ENSP000002624264) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NKX2-1ENSP000003468794STRING: ENSP00000346879
    About this table

    Gene Ontology (GO): 5/57 biological process terms (GO ID links to tree view) (see all 57):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IBA--
    GO:0001568blood vessel development IMP19500772
    GO:0001570vasculogenesis IEA--
    GO:0001701in utero embryonic development IMP19500772
    GO:0001756somitogenesis IEA--

    FOXF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FOXF1

    Search CenterWatch for drugs/clinical trials and news about FOXF1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FOXF1 gene: 
    NM_001451.2  

    Unigene Cluster for FOXF1:

    Forkhead box F1
    Hs.155591  [show with all ESTs]
    Unigene Representative Sequence: NM_001451
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000262426(uc002fjl.3)
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidFOXF1 3' UTR sequence
    Inhib. RNA
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXF1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXF1

    Additional mRNA sequence: 

    AK314167.1 BC089442.1 U13219.1 

    1 DOTS entry:

    DT.455469 

    24/39 AceView cDNA sequences (see all 39):

    AY312577 AI659183 R21764 AA913594 CB053550 CF125661 AA907419 BF475688 
    CA438612 NM_001451 CA438971 AA179538 BQ021034 U13219 BQ072398 AW239043 
    AI991159 AI801183 BF002866 AW182105 AI049652 AA902202 BG402222 AA179507 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FOXF1 expression in normal human tissues (normalized intensities)      FOXF1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCCTCCTCT
    FOXF1 Expression
    About this image


    FOXF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/22 selected tissues (see all 22) fully expand
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 5 entries
             Airway Smooth Muscle Cells Trachea
             Human Bladder Smooth Muscle Cells (HBdSMC)   
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 5 entries
             Mesencephalic Neural Crest Cells Prechordal Mesenchyme
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Lung (Respiratory System)    fully expand to see all 4 entries
             Distal Mesodermal Progenitor Cells Lung Mesoderm
             Human Bronchial Smooth Muscle Cells (HBSM)   
     
     Lower Urinary Tract (Muscoskeletal System)    fully expand to see all 4 entries
             Human Bladder Smooth Muscle Cells (HBdSMC)   
             visceral organ   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             Intervertebral Disc Annulus Fibrosus Cells Thoracic Intervertebral Disc

    See FOXF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FOXF1

    SOURCE GeneReport for Unigene cluster: Hs.155591

    UniProtKB/Swiss-Prot: FOXF1_HUMAN, Q12946
    Tissue specificity: Expressed in lung and placenta

        SABiosciences Expression via Pathway-Focused PCR Arrays including FOXF1: 
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              Angiogenic Growth Factors in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FOXF1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Foxf11 , 5 forkhead box F1a5
    forkhead box F11
    89.27(n)1
    94.15(a)1
      8 (70.31 cM)5
    152271  NM_010426.21  NP_034556.21 
     1210843865 
    chicken
    (Gallus gallus)
    Aves FOXF11 forkhead box F1 84.32(n)
    91.22(a)
      395624  XM_414186.3  XP_414186.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.1822 Xenopus laevis mRNA for XFD-13 protein 78.27(n)    AJ242680.1 
    zebrafish
    (Danio rerio)
    Actinopterygii foxf11 forkhead box F1 72.93(n)
    82.08(a)
      566407  NM_001080186.1  NP_001073655.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bin6
    biniou
    14(a)
    1 → many
    3L(6983722-6987544)
    worm
    (Caenorhabditis elegans)
    Secernentea let-3816
    Protein LET-381
    24(a)
    1 → many
    I(6320359-6323993)


    ENSEMBL Gene Tree for FOXF1 (if available)
    TreeFam Gene Tree for FOXF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FOXF1 gene
    FOXA22  FOXF22  FOXD4L12  FOXC22  FOXI22  FOXB12  FOXE32  FOXC12  
    FOXD4L22  FOXD4L32  FOXA32  FOXD4L52  FOXD12  FOXD32  FOXD4L42  FOXL12  
    FOXA12  FOXE12  FOXB22  FOXI12  FOXD4L62  FOXS12  FOXD22  FOXL22  
    FOXD42  
    3 SIMAP similar genes for FOXF1 using alignment to 2 protein entries:     FOXF1_HUMAN (see all proteins):
    FOXF2    FOXL1    FOXB1

    FOXF1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/187 SNPs in FOXF1 are shown (see all 187)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs561300031,2
    C--86547153(+) TTTAT-/TTTTTT 1 -- ut310--------
    rs1925454151,2
    --87546264(+) GCCCCC/GCTCTT 1 -- us2k10--------
    rs769796881,2
    C--87546316(+) CAGTCG/TCTGCG 1 -- us2k10--------
    rs758270891,2
    C,F--87546399(+) CGGCAC/TCACCT 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1174023721,2
    C,F--87546626(+) TCCCCC/GCTCCC 1 -- us2k11Minor allele frequency- G:0.05EA 120
    rs1129021031,2
    C,F--87546748(+) GGAACG/CTGCGC 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1464291821,2
    --87546767(+) CGGGGA/CCGCGG 1 -- us2k10--------
    rs1825781351,2
    --87546812(+) GTGGGA/GGAGGG 1 -- us2k10--------
    rs750485051,2
    C,F--87546848(+) TCCGAG/TCGTGG 1 -- us2k12Minor allele frequency- T:0.04CSA NA 122
    rs1490203351,2
    --87546849(+) CCGAGC/GGTGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FOXF1 (86544133 - 86548076 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for FOXF1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv525024CNV Loss19592680
    nsv527579CNV Loss19592680
    nsv907132CNV Loss21882294
    esv29890CNV Loss19812545
    nsv907133CNV Loss21882294
    nsv9468CNV Gain18304495
    dgv498n67CNV Gain20364138
    esv4262CNV Complex18987735


    Human Gene Mutation Database (HGMD): FOXF1
    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing FOXF1:
    Birth Defects
    SeqTarget long-range PCR primers for resequencing FOXF1
    DNA2.0 Custom Variant and Variant Library Synthesis for FOXF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601089   
    OMIM disorders: 265380  
    UniProtKB/Swiss-Prot: FOXF1_HUMAN, Q12946
  • Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) [MIM:265380]: A rare
    developmental disorder characterized by abnormal development of the capillary vascular system in the lungs.
    Histological features include failure of formation and ingrowth of alveolar capillaries, medial muscular
    thickening of small pulmonary arterioles with muscularization of the intraacinar arterioles, thickened alveolar
    walls, and anomalously situated pulmonary veins running alongside pulmonary arterioles and sharing the same
    adventitial sheath. Less common features include a reduced number of alveoli and a patchy distribution of the
    histopathologic changes. Affected infants present with respiratory distress and the disease is fatal within the
    newborn period. Additional features include multiple congenital anomalies affecting the cardiovascular,
    gastrointestinal, genitourinary, and musculoskeletal systems, as well as disruption of the normal right-left
    asymmetry of intrathoracic or intraabdominal organs. ACDMPV is a rare cause of persistent pulmonary hypertension
    of the newborn, an abnormal physiologic state caused by failure of transition of the pulmonary circulation from
    the high pulmonary vascular resistance of the fetus to the low pulmonary vascular resistance of the newborn.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 12 diseases for FOXF1:    About MalaCards
    nonspecific interstitial pneumonia    alveolar capillary dysplasia with misalignment of pulmonary veins    alveolar capillary dysplasia    vacterl association
    esophageal atresia    lymphedema    pneumonia    rhabdomyosarcoma
    esophagitis    lung cancer    hypertension    neuronitis

    1 disease from the University of Copenhagen DISEASES database for FOXF1:
    VACTERL association

    FOXF1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FOXF1
    Human Genome Epidemiology (HuGE) Navigator: FOXF1 (4 documents)

    Export disorders for FOXF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FOXF1 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with FOXF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. (PubMed id 7957066)1, 2, 3 Pierrou S....Carlsson P. (1994)
    2. Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2. (PubMed id 8626802)1, 2, 9 Hellqvist M.... Carlsson P. (1996)
    3. Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (2010)
    4. Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (2010)
    5. Genomic and genic deletions of the FOX gene cluster o n 16q24.1 and inactivating mutations of FOXF1 cause alveolar capillary dysplasi a and other malformations. (PubMed id 19500772)1, 2 Stankiewicz P....Shaw-Smith C. (2009)
    6. Candidate gene analysis in primary lymphedema. (PubMed id 18564921)1, 4 Ferrell R.E....Finegold D.N. (2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. FREAC-1 contains a cell-type-specific transcriptional activation domain and is expressed in epithelial-mesenchymal interfaces. (PubMed id 9769171)1, 2 Mahlapuu M.... Carlsson P. (1998)
    9. Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12). (PubMed id 8825632)1, 3 Larsson C....Carlsson P. (1995)
    10. The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB. (PubMed id 9722567)1, 9 Hellqvist M.... Carlsson P. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2294 HGNC: 3809 AceView: FOXF1 Ensembl:ENSG00000103241 euGenes: HUgn2294
    ECgene: FOXF1 H-InvDB: FOXF1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FOXF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FOXF1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FOXF1 gene:
    Search GeneIP for patents involving FOXF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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