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FOXF1 Gene

protein-coding   GIFtS: 58
GCID: GC16P086544

Forkhead Box F1


(Previous symbol: FKHL5)
  See FOXF1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Forkhead Box F11 2     FREAC-12 3
FKHL51 2 3 5     FREAC12 3
Forkhead-Related Activator 12 3     ACDMPV2 5
Forkhead-Related Protein FKHL52 3     Forkhead Box Protein F12
Forkhead-Related Transcription Factor 12 3     Forkhead, Drosophila, Homolog-Like 52

External Ids:    HGNC: 38091   Entrez Gene: 22942   Ensembl: ENSG000001032417   OMIM: 6010895   UniProtKB: Q129463   

Export aliases for FOXF1 gene to outside databases

Previous GC identifers: GC16P077898 GC16P087577 GC16P086284 GC16P086325 GC16P085101 GC16P072284


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FOXF1 Gene:
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead
domain. The specific function of this gene has not yet been determined; however, it may play a role in the
regulation of pulmonary genes as well as embryonic development. (provided by RefSeq, Jul 2008)

GeneCards Summary for FOXF1 Gene:
FOXF1 (forkhead box F1) is a protein-coding gene. Diseases associated with FOXF1 include alveolar capillary dysplasia, and fibrillary astrocytoma. GO annotations related to this gene include sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is FOXQ1.

UniProtKB/Swiss-Prot: FOXF1_HUMAN, Q12946
Function: Probable transcription activator for a number of lung-specific genes

Gene Wiki entry for FOXF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the FOXF1 gene promoter:
         E2F   p53   FOXO4   STAT3   MyoD   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOXF1 promoter sequence
   Search Chromatin IP Primers for FOXF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FOXF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24   Ensembl cytogenetic band:  16q24.1   HGNC cytogenetic band: 16q24

FOXF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXF1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P086544:  view genomic region     (about GC identifiers)

Start:
86,544,133 bp from pter      End:
86,548,076 bp from pter
Size:
3,944 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FOXF1_HUMAN, Q12946 (See protein sequence)
Recommended Name: Forkhead box protein F1  
Size: 379 amino acids; 40122 Da
Developmental stage: Expressed in fetal lung
Caution: It is uncertain whether Met-1 or Met-26 is the initiator
Sequence caution: Sequence=AAC50399.1; Type=Erroneous initiation; Sequence=AAC61576.1; Type=Erroneous initiation;
Sequence=AAH89442.1; Type=Erroneous initiation; Sequence=BAG36851.1; Type=Frameshift; Positions=Several;
Secondary accessions: B2RAF4 Q5FWE5

Explore the universe of human proteins at neXtProt for FOXF1: NX_Q12946

Explore proteomics data for FOXF1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FOXF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001442.2  
    ENSEMBL proteins: 
     ENSP00000262426  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FOX: Forkhead boxes

    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry Q12946

    ProtoNet protein and cluster: Q12946

    UniProtKB/Swiss-Prot: FOXF1_HUMAN, Q12946
    Domain: Activation domains C-terminal of (and distinct from) the forkhead domains are necessary for
    transcriptional activation
    Similarity: Contains 1 fork-head DNA-binding domain


    Find genes that share domains with FOXF1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOXF1_HUMAN, Q12946
    Function: Probable transcription activator for a number of lung-specific genes

         Genatlas biochemistry entry for FOXF1:
    transcription factor-like 5,with a Drosophila homeo fork head DNA binding domain homolog,containing a CGG repeat
    in 5'utr

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA9769171
    GO:0003690double-stranded DNA binding IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IBA--
    GO:0008134transcription factor binding IBA--
         
    Find genes that share ontologies with FOXF1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FOXF1:
     Decreased circadian period len 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Foxf1):
     cardiovascular system  digestive/alimentary  embryogenesis  mortality/aging  muscle 
     respiratory system 

    Find genes that share phenotypes with FOXF1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Foxf1tm1Pca for FOXF1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FOXF1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FOXF1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FOXF1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FOXF1

    miRNA
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    Block miRNA regulation of human, mouse, rat FOXF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FOXF1 (see all 53):
    hsa-miR-2052 hsa-miR-4291 hsa-miR-607 hsa-miR-429 hsa-miR-106a hsa-miR-875-5p hsa-miR-374c hsa-miR-3161
    SwitchGear 3'UTR luciferase reporter plasmidFOXF1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FOXF1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: FOXF1 (NM_001451)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXF1

    Cell Line
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    ESI BIO PureStem Progenitors for FOXF1: 
    PureStem 7PEND24, NCr-fac & Meso-prx Progenitor, PureStem SM30, NCr-fac & Meso-latp Progenitor
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXF1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FOXF1_HUMAN, Q12946: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IC9769171
    GO:0005667transcription factor complex IBA--

    Find genes that share ontologies with FOXF1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FOXF1 About    
    See pathways by source

    SuperPathContained pathways About
    1Selected targets of C EBPbeta
    Selected targets of C EBPbeta
    2FOXA2 and FOXA3 transcription factor networks
    FOXA2 and FOXA3 transcription factor networks


    1 BioSystems Pathway for FOXF1
        FOXA2 and FOXA3 transcription factor networks


        Pathway & Disease-focused RT2 Profiler PCR Arrays including FOXF1: 
              Notch Signaling Targets in human mouse rat
              Angiogenic Growth Factors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FOXF1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for FOXF1 (ENSP000002624264) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NKX2-1ENSP000003468794STRING: ENSP00000346879
    NFIL3ENSP000002976894STRING: ENSP00000297689
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 56):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IBA--
    GO:0001568blood vessel development IMP19500772
    GO:0001570vasculogenesis IEA--
    GO:0001701in utero embryonic development IMP19500772
    GO:0001756somitogenesis IEA--

    Find genes that share ontologies with FOXF1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FOXF1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FOXF1 gene: 
    NM_001451.2  

    Unigene Cluster for FOXF1:

    Forkhead box F1
    Hs.155591  [show with all ESTs]
    Unigene Representative Sequence: NM_001451
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000262426(uc002fjl.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat FOXF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FOXF1 (see all 53):
    hsa-miR-2052 hsa-miR-4291 hsa-miR-607 hsa-miR-429 hsa-miR-106a hsa-miR-875-5p hsa-miR-374c hsa-miR-3161
    SwitchGear 3'UTR luciferase reporter plasmidFOXF1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FOXF1
    Predesigned siRNA for gene silencing in human, mouse, rat FOXF1
    Clone
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    GenScript: all cDNA clones in your preferred vector: FOXF1 (NM_001451)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXF1
    Primer
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    OriGene qPCR primer pairs and template standards for FOXF1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FOXF1
      QuantiTect SYBR Green Assays in human, mouse, rat FOXF1
      QuantiFast Probe-based Assays in human, mouse, rat FOXF1

    Additional mRNA sequence: 

    AK314167.1 BC089442.1 U13219.1 

    1 DOTS entry:

    DT.455469 

    Selected AceView cDNA sequences (see all 39):

    R21764 AY312577 AI659183 AA913594 CB053550 CA438612 CF125661 AI049652 
    NM_001451 AA179538 BF475688 AI801183 BF002866 BQ021034 AW239043 BQ072398 
    AW182105 AI991159 U13219 AA907419 CA438971 N71125 BQ005215 BM992766 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FOXF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCCTCCTCT
    FOXF1 Expression
    About this image


    FOXF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Mesoderm (Gastrulation Derivatives)    fully expand to see all 3 entries
             Mesoderm Cells Mesoderm
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Primitive Streak (Early Embryonic Tissues)
             Mesendoderm-like cells
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
    FOXF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FOXF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.155591

    UniProtKB/Swiss-Prot: FOXF1_HUMAN, Q12946
    Tissue specificity: Expressed in lung and placenta

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FOXF1: 
              Notch Signaling Targets in human mouse rat
              Angiogenic Growth Factors in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FOXF1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Foxf11 , 5 forkhead box F1a5
    forkhead box F11
    88.92(n)1
    93.88(a)1
      8 (70.31 cM)5
    152271  NM_010426.21  NP_034556.21 
     1210843865 
    chicken
    (Gallus gallus)
    Aves FOXF11 forkhead box F1 84.91(n)
    91.98(a)
      395624  XM_414186.4  XP_414186.4 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.1822 Xenopus laevis mRNA for XFD-13 protein 78.27(n)    AJ242680.1 
    zebrafish
    (Danio rerio)
    Actinopterygii foxf11 forkhead box F1 70.9(n)
    78.38(a)
      566407  NM_001080186.1  NP_001073655.1 


    ENSEMBL Gene Tree for FOXF1 (if available)
    TreeFam Gene Tree for FOXF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FOXF1 gene
    FOXQ12  FOXN32  FOXJ12  FOXF22  FOXK12  FOXN42  FOXR12  FOXH12  
    FOXK22  FOXN12  FOXJ32  FOXG12  FOXJ22  FOXN22  FOXR22  
    3 SIMAP similar genes for FOXF1 using alignment to 2 protein entries:     FOXF1_HUMAN (see all proteins):
    FOXF2    FOXL1    FOXB1

    Find genes that share paralogs with FOXF1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FOXF1 (see all 187)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs561300031,2
    C--86547153(+) TTTAT-/TTTTTT 1 -- ut310--------
    rs1925454151,2
    --87546264(+) GCCCCC/GCTCTT 1 -- us2k10--------
    rs769796881,2
    C--87546316(+) CAGTCG/TCTGCG 1 -- us2k10--------
    rs758270891,2
    C,F--87546399(+) CGGCAC/TCACCT 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1174023721,2
    C,F--87546626(+) TCCCCC/GCTCCC 1 -- us2k11Minor allele frequency- G:0.05EA 120
    rs1129021031,2
    C,F--87546748(+) GGAACG/CTGCGC 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1464291821,2
    --87546767(+) CGGGGA/CCGCGG 1 -- us2k10--------
    rs1825781351,2
    --87546812(+) GTGGGA/GGAGGG 1 -- us2k10--------
    rs750485051,2
    C,F--87546848(+) TCCGAG/TCGTGG 1 -- us2k12Minor allele frequency- T:0.04CSA NA 122
    rs1490203351,2
    --87546849(+) CCGAGC/GGTGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FOXF1 (86544133 - 86548076 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for FOXF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv525024CNV Loss19592680
    nsv527579CNV Loss19592680
    nsv907132CNV Loss21882294
    esv29890CNV Loss19812545
    nsv907133CNV Loss21882294
    nsv9468CNV Gain18304495
    dgv498n67CNV Gain20364138
    esv4262CNV Complex18987735

    Human Gene Mutation Database (HGMD): FOXF1
    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing FOXF1:
    Birth Defects
    SeqTarget long-range PCR primers for resequencing FOXF1
    DNA2.0 Custom Variant and Variant Library Synthesis for FOXF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601089   
    OMIM disorders: 265380  
    UniProtKB/Swiss-Prot: FOXF1_HUMAN, Q12946
  • Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) [MIM:265380]: A rare
    developmental disorder characterized by abnormal development of the capillary vascular system in the lungs.
    Histological features include failure of formation and ingrowth of alveolar capillaries, medial muscular
    thickening of small pulmonary arterioles with muscularization of the intraacinar arterioles, thickened alveolar
    walls, and anomalously situated pulmonary veins running alongside pulmonary arterioles and sharing the same
    adventitial sheath. Less common features include a reduced number of alveoli and a patchy distribution of the
    histopathologic changes. Affected infants present with respiratory distress and the disease is fatal within the
    newborn period. Additional features include multiple congenital anomalies affecting the cardiovascular,
    gastrointestinal, genitourinary, and musculoskeletal systems, as well as disruption of the normal right-left
    asymmetry of intrathoracic or intraabdominal organs. ACDMPV is a rare cause of persistent pulmonary hypertension
    of the newborn, an abnormal physiologic state caused by failure of transition of the pulmonary circulation from
    the high pulmonary vascular resistance of the fetus to the low pulmonary vascular resistance of the newborn.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 5 diseases for FOXF1:    
    About MalaCards
    alveolar capillary dysplasia    fibrillary astrocytoma    nonspecific interstitial pneumonia    vacterl association
    annular pancreas

    1 disease from the University of Copenhagen DISEASES database for FOXF1:
    VACTERL association

    Find genes that share disorders with FOXF1           About GenesLikeMe

    Genetic Association Database (GAD): FOXF1
    Human Genome Epidemiology (HuGE) Navigator: FOXF1 (4 documents)

    Export disorders for FOXF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FOXF1 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with FOXF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. (PubMed id 7957066)1, 2, 3 Pierrou S.... Carlsson P. (EMBO J. 1994)
    2. Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2. (PubMed id 8626802)1, 2, 9 Hellqvist M.... Carlsson P. (J. Biol. Chem. 1996)
    3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    5. Genomic and genic deletions of the FOX gene cluster on 16q24.1 and inactivating mutations of FOXF1 cause alveolar capillary dysplasia and other malformations. (PubMed id 19500772)1, 2 Stankiewicz P.... Shaw-Smith C. (Am. J. Hum. Genet. 2009)
    6. Candidate gene analysis in primary lymphedema. (PubMed id 18564921)1, 4 Ferrell R.E....Finegold D.N. (Lymphat Res Biol 2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. FREAC-1 contains a cell-type-specific transcriptional activation domain and is expressed in epithelial-mesenchymal interfaces. (PubMed id 9769171)1, 2 Mahlapuu M.... Carlsson P. (Dev. Biol. 1998)
    9. Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12). (PubMed id 8825632)1, 3 Larsson C....Carlsson P. (Genomics 1995)
    10. The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB. (PubMed id 9722567)1, 9 Hellqvist M.... Carlsson P. (J. Biol. Chem. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2294 HGNC: 3809 AceView: FOXF1 Ensembl:ENSG00000103241 euGenes: HUgn2294
    ECgene: FOXF1 H-InvDB: FOXF1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FOXF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FOXF1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FOXF1 gene:
    Search GeneIP for patents involving FOXF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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