Aliases for FOXE3 Gene
External Ids for FOXE3 Gene
Previous HGNC Symbols for FOXE3 Gene
Previous GeneCards Identifiers for FOXE3 Gene
This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. The protein encoded functions as a lens-specific transcription factor and plays an important role in vertebrate lens formation. Mutations in this gene are associated with anterior segment mesenchymal dysgenesis and congenital primary aphakia. [provided by RefSeq, Dec 2009]
GeneCards Summary for FOXE3 Gene
FOXE3 (Forkhead Box E3) is a Protein Coding gene. Diseases associated with FOXE3 include Anterior Segment Dysgenesis 2, Multiple Subtypes and Cataract 34, Multiple Types. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXE1.
UniProtKB/Swiss-Prot for FOXE3 Gene
Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (PubMed:22527307, PubMed:25504734). During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (By similarity). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (By similarity). Controls the expression of DNAJB1 in a pathway that is crucial for the development of the anterior segment of the eye (PubMed:27218149).