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FOXE3 Gene

protein-coding   GIFtS: 49
GCID: GC01P047881

Forkhead Box E3


(Previous symbol: FKHL12)
  See FOXE3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Forkhead Box E31 2     FREAC82 3
FKHL121 2 3 5     Forkhead Box Protein E32
Forkhead-Related Protein FKHL122 3     Forkhead, Drosophila, Homolog-Like 122
Forkhead-Related Transcription Factor 82 3     ASMD5
FREAC-82 3     

External Ids:    HGNC: 38081   Entrez Gene: 23012   Ensembl: ENSG000001867907   OMIM: 6010945   UniProtKB: Q134613   

Export aliases for FOXE3 gene to outside databases

Previous GC identifers: GC01P047507 GC01P046770 GC01P047240 GC01P047251 GC01P047593 GC01P047654 GC01P045998


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FOXE3 Gene:
This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct
forkhead domain. The protein encoded functions as a lens-specific transcription factor and plays an important
role in vertebrate lens formation. Mutations in this gene are associated with anterior segment mesenchymal
dysgenesis and congenital primary aphakia. (provided by RefSeq, Dec 2009)

GeneCards Summary for FOXE3 Gene:
FOXE3 (forkhead box E3) is a protein-coding gene. Diseases associated with FOXE3 include congenital aphakia, and foxe3-related cataracts, autosomal dominant. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOXA2.

Gene Wiki entry for FOXE3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the FOXE3 gene promoter:
         GR   RP58   HOXA3   Nkx2-5   c-Ets-1   CREB   CP2   FOXO4   deltaCREB   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOXE3 promoter sequence
   Search Chromatin IP Primers for FOXE3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FOXE3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32   Ensembl cytogenetic band:  1p33   HGNC cytogenetic band: 1p32

FOXE3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXE3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P047881:  view genomic region     (about GC identifiers)

Start:
47,881,744 bp from pter      End:
47,883,724 bp from pter
Size:
1,981 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FOXE3_HUMAN, Q13461 (See protein sequence)
Recommended Name: Forkhead box protein E3  
Size: 319 amino acids; 33234 Da
Developmental stage: Expressed in the lens during embryonic development. Predominantly expressed in the anterior
lens epithelium but with some expression posteriorly. Not expressed in brain in embryos
Secondary accessions: Q5SVY9 Q9NQV9

Explore the universe of human proteins at neXtProt for FOXE3: NX_Q13461

REFSEQ proteins: NP_036318.1  
ENSEMBL proteins: 
 ENSP00000334472  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
FOX: Forkhead boxes

3 InterPro protein domains:
 IPR011991 WHTH_DNA-bd_dom
 IPR018122 TF_fork_head_CS
 IPR001766 TF_fork_head

Graphical View of Domain Structure for InterPro Entry Q13461

ProtoNet protein and cluster: Q13461

UniProtKB/Swiss-Prot: FOXE3_HUMAN, Q13461
Similarity: Contains 1 fork-head DNA-binding domain


Find genes that share domains with FOXE3           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:
     Genatlas biochemistry entry for FOXE3:
transcription factor-like 12,with a Drosophila homeo forkhead DNA binding domain homolog

     Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003690double-stranded DNA binding IBA--
GO:0003700sequence-specific DNA binding transcription factor activity TAS8825632
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IBA--
GO:0008134transcription factor binding IBA--
GO:0008301DNA binding, bending IBA--
     
Find genes that share ontologies with FOXE3           About GenesLikeMe


Phenotypes:
     4 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Foxe3):
 behavior/neurological  cardiovascular system  nervous system  vision/eye 

Find genes that share phenotypes with FOXE3           About GenesLikeMe

Animal Models:
     MGI mouse knock-outs for FOXE3: Foxe3tm1Mjam Foxe3tm1Pca

   genOway: Develop your customized and physiologically relevant rodent model for FOXE3

miRNA
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Inhib. RNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
FOXE3_HUMAN, Q13461: Nucleus
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol2

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--
GO:0005667transcription factor complex IDA10652278

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FOXE3
Interactions:

    Search GeneGlobe Interaction Network for FOXE3

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for FOXE3 (ENSP000003344724) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
RNPS1ENSP000003158594STRING: ENSP00000315859
SALL4ENSP000002170864STRING: ENSP00000217086
SALL1ENSP000002510204STRING: ENSP00000251020
--ENSP000002994664STRING: ENSP00000299466
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Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000122negative regulation of transcription from RNA polymerase II promoter IBA--
GO:0001654eye development ----
GO:0002089lens morphogenesis in camera-type eye IBA--
GO:0006355regulation of transcription, DNA-templated ----
GO:0006366transcription from RNA polymerase II promoter IDA10652278

Find genes that share ontologies with FOXE3           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for FOXE3



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for FOXE3 gene: 
NM_012186.2  

Unigene Cluster for FOXE3:

Forkhead box E3
Hs.112968  [show with all ESTs]
Unigene Representative Sequence: AF275722
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000335071(uc001crk.3)
miRNA
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hsa-miR-486-3p
SwitchGear 3'UTR luciferase reporter plasmidFOXE3 3' UTR sequence
Inhib. RNA
Products:
     
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  QuantiFast Probe-based Assays in human, mouse, rat FOXE3

Additional mRNA sequence: AF275722.1 

2 DOTS entries:

DT.103174  DT.99997576 

9 AceView cDNA sequences:

BM670228 AA641009 NM_012186 CD675500 AF275722 CD674161 BM712165 AA621310 
BX090569 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FOXE3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACTTACTTGC
FOXE3 Expression
About this image


FOXE3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 8) fully expand
 
 Eye (Sensory Organs)    fully expand to see all 6 entries
         Lens Placode Cells Lens Placode
 
 Epithelial Cells
         Anterior Lens Epithelial Cells Lens
 
 Brain (Nervous System)    fully expand to see all 4 entries
         Cerebral Cortex
 
 Neural Tube (Nervous System)    fully expand to see all 3 entries
         Metencephalon
         Floor plate-like cells
 
 Thymus (Hematopoietic System)
         Thymus
FOXE3 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.112968
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXE3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for FOXE3 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Foxe35 forkhead box E3   --   4 (52.73 cM) 114925147 
chicken
(Gallus gallus)
Aves FOXE36
forkhead box E3
40(a)
1 ↔ 1
8(20873411-20875481)
lizard
(Anolis carolinensis)
Reptilia FOXE36
forkhead box E3
58(a)
1 ↔ 1
GL343249.1(1609961-1610970)
zebrafish
(Danio rerio)
Actinopterygii foxe36
forkhead box E3
33(a)
1 ↔ 1
8(20206672-20208323) ENSDARG00000062892


ENSEMBL Gene Tree for FOXE3 (if available)
TreeFam Gene Tree for FOXE3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for FOXE3 gene
FOXA22  FOXD4L12  FOXC22  FOXI22  FOXB12  FOXC12  FOXD4L22  FOXD4L32  
FOXA32  FOXD4L52  FOXD12  FOXD32  FOXD4L42  FOXA12  FOXE12  FOXL12  
FOXB22  FOXI12  FOXD4L62  FOXS12  FOXD22  FOXL22  FOXD42  
12 SIMAP similar genes for FOXE3 using alignment to 1 protein entry:     FOXE3_HUMAN:
FOXC1    FOXD4L5    FOXD4L3    FOXE1    FOXD2    FOXD4
FOXD4L1    FOXD4L2    FOXD4L4    FOXD4L6    FOXA1    FOXA2

Find genes that share paralogs with FOXE3           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FOXE3 (see all 87)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0625844
Anterior segment mesenchymal dysgenesis (ASMD)4--see VAR_0625842 R L mis40--------
rs803581941,2
Cpathogenic147882707(+) TGCTGA/CGCCGC 2 * C stg10--------
rs340823591,2
C,Funtested147882497(+) CGCGCC/TGAGCT 2 A syn14Minor allele frequency- T:0.39NA EU 497
rs1167697261,2
F--47879747(+) TCTATC/TATAAC 1 -- us2k11Minor allele frequency- T:0.02WA 118
rs66737891,2
C,F,A--47879762(+) AGTTGT/CCTGTC 1 -- us2k1 tfbs36Minor allele frequency- C:0.24WA CSA NA EA 363
rs66738821,2
C,F,H--47879793(+) TTCATC/TTCTGT 1 -- us2k117Minor allele frequency- T:0.37NS EA NA WA CSA 794
rs1883644891,2
--47879841(+) TACTCA/GGTGAG 1 -- us2k10--------
rs1385888831,2
--47879910(+) TGGAAC/TTGACG 1 -- us2k10--------
rs768956111,2
C--47879949(+) GTGAGT/GGGGGA 1 -- us2k12Minor allele frequency- G:0.12CSA WA 120
rs120263791,2
C,A--47880002(+) GTGGTG/AGGAAG 1 -- us2k1 trp34Minor allele frequency- A:0.07NA EA 244

HapMap Linkage Disequilibrium report for FOXE3 (47881744 - 47883724 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for FOXE3:    About this table    
Variant IDTypeSubtypePubMed ID
nsv871961CNV Loss21882294

Human Gene Mutation Database (HGMD): FOXE3
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing FOXE3
DNA2.0 Custom Variant and Variant Library Synthesis for FOXE3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 601094   
OMIM disorders: 107250  610256  
UniProtKB/Swiss-Prot: FOXE3_HUMAN, Q13461
  • Anterior segment mesenchymal dysgenesis (ASMD) [MIM:107250]: A range of developmental defects in
    structures at the front of the eye, resulting from abnormal migration or differentiation of the neural crest
    derived mesenchymal cells that give rise to the cornea, iris, and other components of the anterior chamber during
    eye development. Different mature anterior segment anomalies may exist alone or in combination, and are
    associated with an increased risk of glaucoma and corneal opacity. Conditions falling within the phenotypic
    spectrum of anterior segment anomalies include aniridia, posterior embryotoxon, Axenfeld anomaly, Reiger
    anomaly/syndrome, Peters anomaly, and iridogoniodysgenesis. Note=The disease is caused by mutations affecting the
    gene represented in this entry
  • Congenital primary aphakia (CPA) [MIM:610256]: Aphakia is a rare congenital eye disorder in which the
    lens is missing. It has been histologically subdivided into primary and secondary forms, in accordance with the
    severity of defects of the ocular tissues, whose development requires the initial presence of a lens. CPA results
    from an early developmental arrest, around the 4th-5th week of gestation in humans, that prevents the formation
    of any lens structure and leads to severe secondary ocular defects, including a complete aplasia of the anterior
    segment of the eye. In contrast, in secondary aphakic eyes, lens induction has occurred, and the lens vesicle has
    developed to some degree but finally has progressively resorbed perinatally, leading, therefore, to less-severe
    ocular defects. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 5 diseases for FOXE3:    
    About MalaCards
    congenital aphakia    foxe3-related cataracts, autosomal dominant    foxe3-related anterior segment mesenchymal dysgenesis    anterior segment mesenchymal dysgenesis
    aniridia

    3 diseases from the University of Copenhagen DISEASES database for FOXE3:
    Congenital aphakia     Microphthalmia     Aniridia

    Find genes that share disorders with FOXE3           About GenesLikeMe

    Genetic Association Database (GAD): FOXE3
    Human Genome Epidemiology (HuGE) Navigator: FOXE3 (1 document)

    Export disorders for FOXE3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FOXE3 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with FOXE3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12). (PubMed id 8825632)1, 2, 3 Larsson C....Carlsson P. (Genomics 1995)
    2. FOXE3 plays a significant role in autosomal recessive microphthalmia. (PubMed id 20140963)1, 4 Reis L.M....Semina E.V. (Am. J. Med. Genet. A 2010)
    3. Seeing clearly: the dominant and recessive nature of FOXE3 in eye developmental anomalies. (PubMed id 19708017)1, 2 Iseri S.U.... Ragge N.K. (Hum. Mutat. 2009)
    4. Homozygous nonsense mutation in the FOXE3 gene as a cause of congenital primary aphakia in humans. (PubMed id 16826526)1, 2 Valleix S.... Kantelip B. (Am. J. Hum. Genet. 2006)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. Mutations in the human forkhead transcription factor FOXE3 associated with anterior segment ocular dysgenesis and cataracts. (PubMed id 11159941)1, 2 Semina E.V.... Jamrich M. (Hum. Mol. Genet. 2001)
    7. An epidemiological investigation of a Forkhead box protein E3 founder mutation underlying the high frequency of sclerocornea, aphakia, and microphthalmia in a Mexican village. (PubMed id 24019743)1 Pantoja-Melendez C....Zenteno J.C. (Mol. Vis. 2013)
    8. Growth inhibition of human lens epithelial cells by short hairpin RNA in transcription factor forkhead box E3 (FOXE3). (PubMed id 22527307)1 Wang Y....Huang Y. (Graefes Arch. Clin. Exp. Ophthalmol. 2012)
    9. A novel, non-stop mutation in FOXE3 causes an autosomal dominant form of variable anterior segment dysgenesis including Peters anomaly. (PubMed id 21150893)1 Doucette L....Young T.L. (Eur. J. Hum. Genet. 2011)
    10. Targeted 'next-generation' sequencing in anophthalmia and microphthalmia patients confirms SOX2, OTX2 and FOXE3 mutations. (PubMed id 22204637)1 Jimenez N.L....Slavotinek A.M. (BMC Med. Genet. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2301 HGNC: 3808 AceView: FOXE3 Ensembl:ENSG00000186790 euGenes: HUgn2301
    ECgene: FOXE3 H-InvDB: FOXE3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FOXE3 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=FOXE3[genesymbol]

    (Patent information from GeneIP,
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    Patent Information for FOXE3 gene:
    Search GeneIP for patents involving FOXE3

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