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FOXE1 Gene

protein-coding   GIFtS: 55
GCID: GC09P100615

Forkhead Box E1 (Thyroid Transcription Factor 2)

(Previous name: forkhead box E2)
(Previous symbols: FKHL15, TITF2, FOXE2)
  See FOXE1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Forkhead Box E1 (Thyroid Transcription Factor 2)1 2     Thyroid Transcription Factor 22 3
FKHL151 2 3 5     HFKH42 3
TITF21 2 3 5     HFKL52 3
FOXE21 2 3     TTF-22 3
TTF22 3 5     HNF-3/Fork Head-Like Protein 52 3
Forkhead Box E21 2     Forkhead Box Protein E12
Forkhead Box Protein E22 3     Forkhead, Drosophila, Homolog-Like 152
Forkhead-Related Protein FKHL152 3     

External Ids:    HGNC: 38061   Entrez Gene: 23042   Ensembl: ENSG000001789197   OMIM: 6026175   UniProtKB: O003583   

Export aliases for FOXE1 gene to outside databases

Previous GC identifers: GC09P091440 GC09P092359 GC09P094072 GC09P095995 GC09P097695 GC09P099655 GC09P070216


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FOXE1 Gene:
This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct
forkhead domain. This gene functions as a thyroid transcription factor which likely plays a crucial role in
thyroid morphogenesis. Mutations in this gene are associated with congenital hypothyroidism and cleft palate with
thyroid dysgenesis. The map localization of this gene suggests it may also be a candidate gene for squamous cell
epithelioma and hereditary sensory neuropathy type I. (provided by RefSeq, Jul 2008)

GeneCards Summary for FOXE1 Gene:
FOXE1 (forkhead box E1 (thyroid transcription factor 2)) is a protein-coding gene. Diseases associated with FOXE1 include bamforth-lazarus syndrome, and thyroid agenesis. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOXA2.

UniProtKB/Swiss-Prot: FOXE1_HUMAN, O00358
Function: Probable transcription factor. Could be involved in thyroid gland organogenesis

Gene Wiki entry for FOXE1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the FOXE1 gene promoter:
         GR   p53   NRSF form 1   NRSF form 2   Nkx6-1   FOXO4   FOXO1a   GR-alpha   Pax-4a   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FOXE1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FOXE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22   Ensembl cytogenetic band:  9q22.33   HGNC cytogenetic band: 9q22

FOXE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXE1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P100615:  view genomic region     (about GC identifiers)

Start:
100,615,536 bp from pter      End:
100,618,997 bp from pter
Size:
3,462 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FOXE1_HUMAN, O00358 (See protein sequence)
Recommended Name: Forkhead box protein E1  
Size: 373 amino acids; 38076 Da
Sequence caution: Sequence=CAA64246.1; Type=Miscellaneous discrepancy; Note=Several conflicts;
Secondary accessions: O75765 Q5T109 Q99526

Explore the universe of human proteins at neXtProt for FOXE1: NX_O00358

Explore proteomics data for FOXE1 at MOPED

Post-translational modifications: 

  • Phosphorylated (By similarity)1
  • Modification sites at neXtProt

  • See FOXE1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004464.2  
    ENSEMBL proteins: 
     ENSP00000364265  

    FOXE1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for FOXE1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FOX: Forkhead boxes

    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry O00358

    ProtoNet protein and cluster: O00358

    UniProtKB/Swiss-Prot: FOXE1_HUMAN, O00358
    Similarity: Contains 1 fork-head DNA-binding domain


    Find genes that share domains with FOXE1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOXE1_HUMAN, O00358
    Function: Probable transcription factor. Could be involved in thyroid gland organogenesis

         Genatlas biochemistry entry for FOXE1:
    transcription factor-like 15,with a Drosophila homeo forkhead DNA binding domain homolog,expressed in the
    developing thyroid,in most of the foregut endoderm,including Rathke pouch

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity ----
    GO:0003677DNA binding IDA9697705
    GO:0003690double-stranded DNA binding IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity IDA9697705
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IBA--
         
    Find genes that share ontologies with FOXE1           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Foxe1):
     craniofacial  digestive/alimentary  endocrine/exocrine gland  homeostasis/metabolism  integument 
     mortality/aging 

    Find genes that share phenotypes with FOXE1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Foxe1tm1Rdl for FOXE1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FOXE1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FOXE1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FOXE1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FOXE1

    miRNA
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    miRTarBase miRNAs that target FOXE1:
    hsa-mir-26b-5p (MIRT028762)

    Block miRNA regulation of human, mouse, rat FOXE1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FOXE1 (see all 13):
    hsa-miR-28-3p hsa-miR-485-3p hsa-miR-513c hsa-miR-548aa hsa-miR-373* hsa-miR-583 hsa-miR-3680 hsa-miR-146a*
    SwitchGear 3'UTR luciferase reporter plasmidFOXE1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FOXE1
    Predesigned siRNA for gene silencing in human, mouse, rat FOXE1

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXE1
    Addgene plasmids for FOXE1 

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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-13132 VA6-13131) for FOXE1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FOXE1_HUMAN, O00358: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9697705
    GO:0005667transcription factor complex IBA--

    Find genes that share ontologies with FOXE1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including FOXE1: 
              Hedgehog Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FOXE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FOXE1 (O003583 ENSP000003642654) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLCB3Q019703, ENSP000002792304I2D: score=1 STRING: ENSP00000279230
    VPS72ENSP000003578874STRING: ENSP00000357887
    MAD2L1ENSP000002965094STRING: ENSP00000296509
    CFDP1ENSP000002838824STRING: ENSP00000283882
    MAD1L1ENSP000003825624STRING: ENSP00000382562
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    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter NAS9169137
    GO:0002089lens morphogenesis in camera-type eye IBA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter ----
    GO:0006590thyroid hormone generation ISS--

    Find genes that share ontologies with FOXE1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FOXE1

    3 Novoseek inferred chemical compound relationships for FOXE1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iodide 62.4 4 16042141 (1), 18211961 (1), 17077129 (1)
    alanine 20.8 9 11580993 (3), 17318017 (3), 15320969 (1)
    sodium 14.5 4 16042141 (1), 18211961 (1), 17077129 (1)



    Find genes that share compounds with FOXE1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FOXE1 gene: 
    NM_004473.3  

    Unigene Cluster for FOXE1:

    Forkhead box E1 (thyroid transcription factor 2)
    Hs.159234  [show with all ESTs]
    Unigene Representative Sequence: U89995
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000375123(uc004axu.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat FOXE1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FOXE1 (see all 13):
    hsa-miR-28-3p hsa-miR-485-3p hsa-miR-513c hsa-miR-548aa hsa-miR-373* hsa-miR-583 hsa-miR-3680 hsa-miR-146a*
    SwitchGear 3'UTR luciferase reporter plasmidFOXE1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FOXE1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FOXE1
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-13132 VA6-13131) for FOXE1 

    Additional mRNA sequence: U89995.1 

    1 DOTS entry:

    DT.204068 

    2 AceView cDNA sequences:

    NM_004473 U89995 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FOXE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAACTTGGT
    FOXE1 Expression
    About this image


    FOXE1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
     
     Thymus (Hematopoietic System)
             Thymus
     
     Thyroid (Endocrine System)
     
     Ovary (Reproductive System)
    FOXE1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FOXE1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.159234

    UniProtKB/Swiss-Prot: FOXE1_HUMAN, O00358
    Tissue specificity: Detected in adult brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, heart,
    colon, small intestine testis and thymus. Expression was strongest in heart and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Array including FOXE1: 
              Hedgehog Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FOXE1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Foxe11 , 5 forkhead box E11, 5 86.65(n)1
    90.19(a)1
      4 (24.68 cM)5
    1108051  NM_183298.11  NP_899121.11 
     463436095 
    chicken
    (Gallus gallus)
    Aves FOXE11 forkhead box E1 (thyroid transcription factor 2) 70.14(n)
    63.89(a)
      768789  XM_003643088.2  XP_003643136.2 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia foxe11 forkhead box E1 (thyroid transcription factor 2) 59.05(n)
    59.52(a)
      100038190  XM_002936683.2  XP_002936729.1 
    zebrafish
    (Danio rerio)
    Actinopterygii foxe11 forkhead box E1 (thyroid transcription factor 2) 61.97(n)
    60.56(a)
      567676  XM_005159910.1  XP_005159967.1 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-1303 fork head domain protein 49(a)   II(11281899-11283574)   --


    ENSEMBL Gene Tree for FOXE1 (if available)
    TreeFam Gene Tree for FOXE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FOXE1 gene
    FOXA22  FOXD4L12  FOXC22  FOXI22  FOXB12  FOXE32  FOXC12  FOXD4L22  
    FOXD4L32  FOXA32  FOXD4L52  FOXD12  FOXD32  FOXD4L42  FOXA12  FOXL12  
    FOXB22  FOXI12  FOXD4L62  FOXS12  FOXD22  FOXL22  FOXD42  
    14 SIMAP similar genes for FOXE1 using alignment to 1 protein entry:     FOXE1_HUMAN:
    FOXC1    FOXD4L2    FOXD4L3    FOXD4L4    FOXD4L6    FOXD4
    FOXA2    FOXD4L5    FOXL2    FOXD3    FOXE3    FOXA3
    FOXL1    FOXD2

    Find genes that share paralogs with FOXE1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    FOXE1_HUMAN, O00358: An alanine stretch that varies from 12 to 19 residues is present. This polymorphisms can be used as
    a marker to study the role of FOXE1 in other cases of thyroid dysgenesis, especially in familial cases


    Selected SNPs for FOXE1 (see all 160)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289375751,2,,4
    CBamforth-Lazarus syndrome (BLS)4 pathogenic1108542108(+) CTACAA/GCTACA 2 N S mis1 ese30--------
    VAR_0088574
    Bamforth-Lazarus syndrome (BLS)4--see VAR_0088572 A V mis40--------
    rs1048941111,2
    Cpathogenic1108541974(+) GCATCC/TGCCAC 2 R C mis10--------
    rs1048941101,2
    Cpathogenic1108542084(+) CATGGC/TCATCG 2 A V mis10--------
    rs1152408131,2
    F--70214661(+) AGGATC/TGCAGG 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs727535061,2
    C,F--70214695(+) ATCACG/ATTAGG 1 -- us2k12Minor allele frequency- A:0.12WA NA 238
    rs37582511,2
    C,F,A,H--70214706(-) ACGACC/GGTTGT 1 -- us2k198Minor allele frequency- G:0.39EA NS PA EU CA WA NA CSA 5642
    rs1444421671,2
    --70214729(+) ATCTAC/GATATC 1 -- us2k10--------
    rs1166947081,2
    F--70214787(+) TAAAAG/AGTGCC 1 -- us2k11Minor allele frequency- A:0.06WA 118
    rs1143895871,2
    F--70214789(+) AAAGGT/CGCCTA 1 -- us2k11Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for FOXE1 (100615536 - 100618997 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FOXE1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6627CNV Loss18451855
    nsv825000CNV Gain20364138
    nsv893611CNV Gain21882294

    Human Gene Mutation Database (HGMD): FOXE1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FOXE1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602617   
    OMIM disorders: 241850  
    UniProtKB/Swiss-Prot: FOXE1_HUMAN, O00358
  • Bamforth-Lazarus syndrome (BLS) [MIM:241850]: A disease characterized by thyroid agenesis, cleft palate
    and choanal atresia. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 14 diseases for FOXE1:    
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    bamforth-lazarus syndrome    thyroid agenesis    cleft palate    mucoepidermoid carcinoma
    choanal atresia    congenital hypothyroidism    charge syndrome    papillary carcinoma
    hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia    hypothyroidism    hereditary sensory neuropathy    papillary thyroid carcinoma
    cleft lip    follicular thyroid carcinoma

    4 diseases from the University of Copenhagen DISEASES database for FOXE1:
    Choanal atresia     Cleft palate     Hypothyroidism     Cleft lip

    Find genes that share disorders with FOXE1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for FOXE1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroid ectopic 93.4 20 11580993 (3), 10403172 (2), 9697705 (2), 16882747 (2) (see all 10)
    congenital hypothyroidism 87.7 14 15320969 (2), 10403172 (1), 11502839 (1), 16042141 (1) (see all 9)
    choanal atresia 78.5 9 9697705 (2), 12203737 (1), 16882747 (1), 12165566 (1)
    cleft palate 68.8 19 12165566 (3), 15320969 (3), 9697705 (2), 10403172 (1) (see all 7)
    hypoplasia 65.3 2 11580993 (1), 12786749 (1)
    carcinoma anaplastic 61.7 3 18084247 (1)
    carcinoma basal cell 46.9 3 15140221 (2), 15367491 (1)
    thyroid diseases 39.9 2 16042141 (1)
    somatic mutations 39.4 1 17684388 (1)
    thyroid papillary carcinoma 36.7 1 11325833 (1)

    Genetic Association Database (GAD): FOXE1
    Human Genome Epidemiology (HuGE) Navigator: FOXE1 (25 documents)

    Export disorders for FOXE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FOXE1 gene, integrated from 10 sources (see all 94):
    (articles sorted by number of sources associating them with FOXE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutation of the gene encoding human TTF-2 associated with thyroid agenesis, cleft palate and choanal atresia. (PubMed id 9697705)1, 2, 3, 9 Clifton-Bligh R.J.... Chatterjee V.K. (Nat. Genet. 1998)
    2. FKHL15, a new human member of the forkhead gene family located on chromosome 9q22. (PubMed id 9169137)1, 2, 3 Chadwick B.P.... Frischauf A.-M. (Genomics 1997)
    3. Polymorphism of the polyalanine tract of thyroid transcription factor-2 gene in patients with thyroid dysgenesis. (PubMed id 11580993)1, 4, 9 Hishinuma A....Ieiri T. (Eur. J. Endocrinol. 2001)
    4. Cloning, chromosomal localization and identification of polymorphisms in the human thyroid transcription factor 2 gene (TITF2). (PubMed id 10403172)1, 2, 9 Macchia P.E.... Di Lauro R. (Biochimie 1999)
    5. A novel missense mutation in human TTF-2 (FKHL15) gene associated with congenital hypothyroidism but not athyreosis. (PubMed id 16882747)1, 2, 9 Baris I.... Battaloglu E. (J. Clin. Endocrinol. Metab. 2006)
    6. A novel loss-of-function mutation in TTF-2 is associated with congenital hypothyroidism, thyroid agenesis and cleft palate. (PubMed id 12165566)1, 2, 9 Castanet M.... Polak M. (Hum. Mol. Genet. 2002)
    7. TTF-2/FOXE1 gene polymorphisms in Sicilian patients with permanent primary congenital hypothyroidism. (PubMed id 17318017)1, 4, 9 Santarpia L....Benvenga S. (J. Endocrinol. Invest. 2007)
    8. Transcription factor mutations and congenital hypothyroidism: systematic genetic screening of a population-based cohort of Japanese patients. (PubMed id 20157192)1, 4, 9 Narumi S....Hasegawa T. (J. Clin. Endocrinol. Metab. 2010)
    9. The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl. (PubMed id 20350937)1, 4 Takahashi M....Yamashita S. (Hum. Mol. Genet. 2010)
    10. MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate. (PubMed id 20572854)1, 4 JagomAogi T....Metspalu A. (Eur. J. Oral Sci. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2304 HGNC: 3806 AceView: FOXE1 Ensembl:ENSG00000178919 euGenes: HUgn2304
    ECgene: FOXE1 H-InvDB: FOXE1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FOXE1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FOXE1 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=FOXE1[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FOXE1 gene:
    Search GeneIP for patents involving FOXE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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