Aliases for FOXE1 Gene
External Ids for FOXE1 Gene
Previous HGNC Symbols for FOXE1 Gene
Previous GeneCards Identifiers for FOXE1 Gene
This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene functions as a thyroid transcription factor which likely plays a crucial role in thyroid morphogenesis. Mutations in this gene are associated with congenital hypothyroidism and cleft palate with thyroid dysgenesis. The map localization of this gene suggests it may also be a candidate gene for squamous cell epithelioma and hereditary sensory neuropathy type I. [provided by RefSeq, Jul 2008]
GeneCards Summary for FOXE1 Gene
FOXE1 (Forkhead Box E1) is a Protein Coding gene. Diseases associated with FOXE1 include Bamforth-Lazarus Syndrome and Thyroid Cancer, Nonmedullary, 4. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXE3.
UniProtKB/Swiss-Prot for FOXE1 Gene
Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression.