Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FOXD4L6 Gene

Aliases for FOXD4L6 Gene

  • Forkhead Box D4-Like 6 2 3
  • FOXD4-Like 6 4

External Ids for FOXD4L6 Gene

Previous GeneCards Identifiers for FOXD4L6 Gene

  • GC09M068489
  • GC09M069199

Summaries for FOXD4L6 Gene

GeneCards Summary for FOXD4L6 Gene

FOXD4L6 (Forkhead Box D4-Like 6) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding and double-stranded DNA binding. An important paralog of this gene is FOXD4L3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXD4L6 Gene

Genomics for FOXD4L6 Gene

Regulatory Elements for FOXD4L6 Gene

Genomic Location for FOXD4L6 Gene

Start:
41,126,251 bp from pter
End:
41,128,975 bp from pter
Size:
2,725 bases
Orientation:
Minus strand

Genomic View for FOXD4L6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXD4L6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXD4L6 Gene

Proteins for FOXD4L6 Gene

  • Protein details for FOXD4L6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3SYB3-FX4L6_HUMAN
    Recommended name:
    Forkhead box protein D4-like 6
    Protein Accession:
    Q3SYB3
    Secondary Accessions:
    • B2RPC4
    • Q4V336

    Protein attributes for FOXD4L6 Gene

    Size:
    417 amino acids
    Molecular mass:
    45787 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • 5 FOXD4-like proteins (FOXD4L2, FOXD4L3, FOXD4L4, FOXD4L5 and FOXD4L6) are encoded by a strongly repeated region of the 9q12 chromosome region. They are very similar and it is therefore difficult to provide a clear and unambiguous protein sequence. Our sequences are in agreement with HGNC nomenclature

neXtProt entry for FOXD4L6 Gene

Proteomics data for FOXD4L6 Gene at MOPED

Post-translational modifications for FOXD4L6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXD4L6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXD4L6 Gene

Domains for FOXD4L6 Gene

Protein Domains for FOXD4L6 Gene

Suggested Antigen Peptide Sequences for FOXD4L6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3SYB3

UniProtKB/Swiss-Prot:

FX4L6_HUMAN :
  • Q3SYB3
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXD4L6: view

No data available for Gene Families for FOXD4L6 Gene

Function for FOXD4L6 Gene

Gene Ontology (GO) - Molecular Function for FOXD4L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXD4L6: view

Animal Model Products

CRISPR Products

miRNA for FOXD4L6 Gene

miRTarBase miRNAs that target FOXD4L6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOXD4L6

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FOXD4L6 Gene

Localization for FOXD4L6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXD4L6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXD4L6 Gene COMPARTMENTS Subcellular localization image for FOXD4L6 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for FOXD4L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with FOXD4L6: view

Pathways for FOXD4L6 Gene

SuperPathways for FOXD4L6 Gene

No Data Available

Interacting Proteins for FOXD4L6 Gene

Selected Interacting proteins: Q3SYB3-FX4L6_HUMAN for FOXD4L6 Gene via UniProtKB

Symbol External ID(s) Details
MDFI

Gene Ontology (GO) - Biological Process for FOXD4L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0009653 anatomical structure morphogenesis IBA --
genes like me logo Genes that share ontologies with FOXD4L6: view

No data available for Pathways by source for FOXD4L6 Gene

Transcripts for FOXD4L6 Gene

mRNA/cDNA for FOXD4L6 Gene

(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXD4L6 Gene

Forkhead box D4-like 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOXD4L6

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXD4L6 Gene

No ASD Table

Relevant External Links for FOXD4L6 Gene

GeneLoc Exon Structure for
FOXD4L6
ECgene alternative splicing isoforms for
FOXD4L6

Expression for FOXD4L6 Gene

mRNA expression in normal human tissues for FOXD4L6 Gene

mRNA differential expression in normal tissues according to GTEx for FOXD4L6 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (6.3), Brain - Cortex (5.9), Brain - Hippocampus (5.7), Brain - Cerebellar Hemisphere (5.5), and Brain - Cerebellum (4.3).

SOURCE GeneReport for Unigene cluster for FOXD4L6 Gene Hs.652377

genes like me logo Genes that share expressions with FOXD4L6: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for FOXD4L6 Gene

Orthologs for FOXD4L6 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for FOXD4L6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXD4L3 35
  • 99.04 (n)
  • 98.32 (a)
Species with no ortholog for FOXD4L6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FOXD4L6 Gene

ENSEMBL:
Gene Tree for FOXD4L6 (if available)
TreeFam:
Gene Tree for FOXD4L6 (if available)

Paralogs for FOXD4L6 Gene

Paralogs for FOXD4L6 Gene

Selected SIMAP similar genes for FOXD4L6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXD4L6: view

Variants for FOXD4L6 Gene

Sequence variations from dbSNP and Humsavar for FOXD4L6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs2482270 -- 41,127,518(+) CCAGG(G/T)CCGCG missense, reference
rs2989709 -- 41,127,137(+) AGCAG(C/G)GCCGA reference, missense
rs62553364 -- 41,127,287(+) GCGGT(C/T)TGGGG missense, reference
rs62553368 -- 41,128,811(+) AAGGC(A/G)CATTT utr-variant-5-prime
rs62553369 -- 41,129,127(+) CCTCC(C/T)CAAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FOXD4L6 Gene

Variant ID Type Subtype PubMed ID
dgv2381e1 CNV Complex 17122850
dgv135n16 CNV Deletion 17901297
esv33449 CNV Loss 17666407
essv17250 CNV CNV 17122850

Relevant External Links for FOXD4L6 Gene

HapMap Linkage Disequilibrium report
FOXD4L6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXD4L6 Gene

Disorders for FOXD4L6 Gene

No disorders were found for FOXD4L6 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FOXD4L6 Gene

Publications for FOXD4L6 Gene

  1. FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines. (PMID: 12234674) Freyaldenhoven B.S. … Wielckens K. (Gene 2002) 3
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3
  5. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3

Products for FOXD4L6 Gene

Sources for FOXD4L6 Gene

Back to Top

Content