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Aliases for FOXD4L5 Gene

Aliases for FOXD4L5 Gene

  • Forkhead Box D4-Like 5 2 3 5
  • FOXD4-Like 5 3 4
  • BA15J10.2 3

External Ids for FOXD4L5 Gene

Previous GeneCards Identifiers for FOXD4L5 Gene

  • GC09M069466
  • GC09M069467
  • GC09M070175

Summaries for FOXD4L5 Gene

GeneCards Summary for FOXD4L5 Gene

FOXD4L5 (Forkhead Box D4-Like 5) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXE3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXD4L5 Gene

Genomics for FOXD4L5 Gene

Regulatory Elements for FOXD4L5 Gene


Genomic Location for FOXD4L5 Gene

Chromosome:
9
Start:
65,282,101 bp from pter
End:
65,285,209 bp from pter
Size:
3,109 bases
Orientation:
Minus strand

Genomic View for FOXD4L5 Gene

Genes around FOXD4L5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXD4L5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXD4L5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXD4L5 Gene

Proteins for FOXD4L5 Gene

  • Protein details for FOXD4L5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VV16-FX4L5_HUMAN
    Recommended name:
    Forkhead box protein D4-like 5
    Protein Accession:
    Q5VV16

    Protein attributes for FOXD4L5 Gene

    Size:
    416 amino acids
    Molecular mass:
    45780 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXD4L5 Gene

Proteomics data for FOXD4L5 Gene at MOPED

Post-translational modifications for FOXD4L5 Gene

No Post-translational modifications

Other Protein References for FOXD4L5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXD4L5 Gene

Domains & Families for FOXD4L5 Gene

Protein Domains for FOXD4L5 Gene

Suggested Antigen Peptide Sequences for FOXD4L5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VV16

UniProtKB/Swiss-Prot:

FX4L5_HUMAN :
  • Contains 1 fork-head DNA-binding domain.
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXD4L5: view

No data available for Gene Families for FOXD4L5 Gene

Function for FOXD4L5 Gene

Gene Ontology (GO) - Molecular Function for FOXD4L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with FOXD4L5: view
genes like me logo Genes that share phenotypes with FOXD4L5: view

Animal Model Products

miRNA for FOXD4L5 Gene

miRTarBase miRNAs that target FOXD4L5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FOXD4L5 Gene

Localization for FOXD4L5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXD4L5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXD4L5 Gene COMPARTMENTS Subcellular localization image for FOXD4L5 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for FOXD4L5 Gene

Pathways & Interactions for FOXD4L5 Gene

SuperPathways for FOXD4L5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXD4L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with FOXD4L5: view

No data available for Pathways by source and SIGNOR curated interactions for FOXD4L5 Gene

Drugs & Compounds for FOXD4L5 Gene

No Compound Related Data Available

Transcripts for FOXD4L5 Gene

mRNA/cDNA for FOXD4L5 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for FOXD4L5 Gene

No ASD Table

Relevant External Links for FOXD4L5 Gene

GeneLoc Exon Structure for
FOXD4L5
ECgene alternative splicing isoforms for
FOXD4L5

Expression for FOXD4L5 Gene

mRNA expression in normal human tissues for FOXD4L5 Gene

SOURCE GeneReport for Unigene cluster for FOXD4L5 Gene Hs.714683

genes like me logo Genes that share expression patterns with FOXD4L5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FOXD4L5 Gene

Orthologs for FOXD4L5 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXD4L5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXD4L4 35
  • 98.38 (n)
  • 97.33 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 50 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii foxd5 36
  • 38 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta fd59A 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-130 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
ManyToMany
CSA.2032 36
  • 22 (a)
ManyToMany
Species with no ortholog for FOXD4L5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FOXD4L5 Gene

ENSEMBL:
Gene Tree for FOXD4L5 (if available)
TreeFam:
Gene Tree for FOXD4L5 (if available)

Paralogs for FOXD4L5 Gene

(13) SIMAP similar genes for FOXD4L5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXD4L5: view

Variants for FOXD4L5 Gene

Sequence variations from dbSNP and Humsavar for FOXD4L5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs112992735 -- 65,285,854(-) TTAGC(C/T)GGGCG upstream-variant-2KB
rs113259255 -- 65,282,170(+) AAATT(A/C)TCTTT utr-variant-3-prime
rs113261639 -- 65,282,116(+) TCCCC(C/T)CTTCT utr-variant-3-prime
rs113702709 -- 65,282,106(+) TTCAA(G/T)ATCCT utr-variant-3-prime
rs113877246 -- 65,282,272(+) CATGA(A/G)AAAGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FOXD4L5 Gene

Variant ID Type Subtype PubMed ID
dgv2381e1 CNV Complex 17122850
dgv135n16 CNV Deletion 17901297
esv33449 CNV Loss 17666407
essv2899 CNV CNV 17122850
nsv508549 CNV Loss 20534489
nsv469665 CNV Complex 16826518
dgv2383e1 CNV Complex 17122850

Variation tolerance for FOXD4L5 Gene

Gene Damage Index Score: 1.89; 35.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXD4L5 Gene

HapMap Linkage Disequilibrium report
FOXD4L5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXD4L5 Gene

Disorders for FOXD4L5 Gene

Relevant External Links for FOXD4L5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXD4L5

No disorders were found for FOXD4L5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXD4L5 Gene

Publications for FOXD4L5 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 67
  2. FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines. (PMID: 12234674) Freyaldenhoven B.S. … Wielckens K. (Gene 2002) 2 3
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for FOXD4L5 Gene

Sources for FOXD4L5 Gene

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