FOXD4L4 Gene
protein-coding GIFtS: 36
GCID: GC09M070427
|
|
forkhead box D4-like 4
| |
Aliases
for FOXD4L4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Forkhead Box D4-Like 41 2 | | FOXD4b2 | | BA460E7.21 | | Forkhead Box Protein D4-Like 42 | | Forkhead Box Protein D4B2 3 | | Winged Helix Factor-12 | | Myeloid Factor-Gamma2 3 | | Winged Helix Transcription Factor Beta2 | | FOXD4-Like 42 3 | | FOXD4B3 | | OTTHUMG000000133371 | | |
Export aliases for FOXD4L4 gene to outside databasesPrevious GC identifers: GC00U921578 GC09U900683 GC09M067938 GC09M069666 |
Summaries
for FOXD4L4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FOXD4L4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NT_113816.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FOXD4L4 gene promoter:
TBP USF1 Tal-1 USF-1 STAT3 FOXD1 USF-1:USF-2 E47 GATA-1 GATA-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for FOXD4L4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXD4L4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q21.11 Ensembl cytogenetic band: 9q21.11 HGNC cytogenetic band: 9q13FOXD4L4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M070427: view genomic region
(about GC identifiers)
Start:
|
70,426,623 bp from pter |
End:
|
70,429,731 bp from pter |
Size:
|
3,109 bases |
Orientation:
|
minus strand |
|
Proteins
for FOXD4L4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FX4L4_HUMAN, Q8WXT5 (See
protein sequence)Recommended Name: Forkhead box protein D4-like 4 Size: 416 amino acids; 45892 Da
Subcellular location: Nucleus (By similarity)
Miscellaneous: 5 FOXD4-like proteins (FOXD4L2, FOXD4L3, FOXD4L4, FOXD4L5 and FOXD4L6) are encoded by a stronglyrepeated region of the 9q12 chromosome region. They are very similar and it is therefore difficult to provide a clearand unambiguous protein sequence. Our sequences are in agreement with HGNC nomenclature
Secondary accessions: Q5RIB4Explore the universe of human proteins at neXtProt for FOXD4L4: NX_Q8WXT5
FOXD4L4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_954714.2
ENSEMBL proteins: ENSP00000366630
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
FOXD4L4 for ontologies About GeneDecksing
FOXD4L4 Antibody Products:
Assay Products for FOXD4L4: |
Protein
Domains /
Families
for FOXD4L4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FOXD4L4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WXT5ProtoNet protein and cluster: Q8WXT5 UniProtKB/Swiss-Prot: FX4L4_HUMAN, Q8WXT5Similarity: Contains 1 fork-head DNA-binding domain |
Function
for FOXD4L4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXD4L4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXD4L4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FOXD4L4 (NM_199244) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOXD4L4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXD4L4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXD4L4 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003690 | double-stranded DNA binding |
IBA | -- | | GO:0003705 | RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity |
IBA | -- | | GO:0008134 | transcription factor binding |
IBA | -- | | GO:0008301 | DNA binding, bending |
IBA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
FOXD4L4 for ontologies About GeneDecksing
|
Pathways & Interactions
for FOXD4L4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOXD4L4
Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001755 | neural crest cell migration |
IBA | -- | | GO:0007389 | pattern specification process |
IBA | -- | | GO:0007422 | peripheral nervous system development |
IBA | -- | | GO:0009790 | embryo development |
IBA | -- | | GO:0030318 | melanocyte differentiation |
IBA | -- |
FOXD4L4 for ontologies About GeneDecksing
|
Drugs & Compounds
for FOXD4L4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FOXD4L4
Search CenterWatch for drugs/clinical trials and news about FOXD4L4 / FX4L4
|
Transcripts
for FOXD4L4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FOXD4L4 gene: NM_199244.2 Unigene Cluster for FOXD4L4: Forkhead box D4-like 4 Hs.534644 Unigene Representative Sequence: NM_1992441 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000377413(uc004afx.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXD4L4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXD4L4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FOXD4L4 (NM_199244) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOXD4L4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXD4L4 |
2 DOTS entries: DT.121145708 DT.121202188 1 AceView cDNA sequence: NM_199244
GeneLoc Exon Structure
|
Expression
for FOXD4L4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FOXD4L4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See FOXD4L4 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.534644
SABiosciences Custom PCR Arrays for FOXD4L4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOXD4L4
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FOXD4L4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXD4L4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXD4L4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXD4L4 |
Orthologs
for FOXD4L4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FOXD4L4 gene from 4/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
54(a) |
1 → many |
2(49994144-49994639) |
zebrafish
(Danio rerio) |
Actinopterygii |
foxd56 |
forkhead box D5 |
31(a) |
1 → many |
8(31300987-31302137) |
fruit fly
(Drosophila melanogaster) |
Insecta |
fd59A6 |
forkhead domain 59A |
19(a) |
1 → many |
2R(18754044-18758229) |
worm
(Caenorhabditis elegans) |
Secernentea |
unc-1306 |
UNCoordinated family member (unc-130) |
25(a) |
possible ortholog |
II(11281922-11283890) |
ENSEMBL Gene Tree for FOXD4L4 (if available)
TreeFam Gene Tree for FOXD4L4 (if available) |
Paralogs
for FOXD4L4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FOXD4L4 gene
- FOXD4L21 2 FOXD4L51 2 FOXF12 FOXA22 FOXD4L12 FOXF22 FOXC22 FOXB12
- FOXI22 FOXE32 FOXC12 FOXQ12 FOXD4L32 FOXA32 FOXD12 FOXD32
- FOXE12 FOXL12 FOXA12 FOXB22 FOXI12 FOXD4L62 FOXS12 FOXL22
- FOXD22 FOXD42
12 SIMAP similar genes for FOXD4L4 using alignment to 1 protein entry: FX4L4_HUMAN:FOXD4L2 FOXD4L5 FOXD4L3 FOXD4L6 FOXD4L1 FOXD4
FOXE1 FOXD3 FOXL1 FOXD2 FOXE3 FOXD1
FOXD4L4 for paralogs About GeneDecksing
|
Genomic Variants
for FOXD4L4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 18 variations for FOXD4L4
15/17 CNVs (see all 17): 0302 7748 8628 96013 82978 31515 3770 22958 2819 82979 23255 3769 96010 96011 70600
1 Inversion: 37337 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for FOXD4L4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FOXD4L4 for disorders About GeneDecksing
2  diseases for FOXD4L4: About MalaCardsleukemia neuronitis
Export disorders for FOXD4L4 gene to outside databases
|
Publications
for FOXD4L4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FOXD4L4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FOXD4L4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines. (PubMed id 12234674)1, 2 Freyaldenhoven B.S.... Wielckens K. (2002)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
- Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. (PubMed id 12421752)1 Fan Y.... Trask B.J. (2002)
- The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription. (PubMed id 11238932)9 Yao J....Stifani S. (2001)
|
External Searches for FOXD4L4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FOXD4L4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FOXD4L4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FOXD4L4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FOXD4L4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FOXD4L4 gene:
Search GeneIP for patents involving FOXD4L4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FOXD4L4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FOXD4L4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOXD4L4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOXD4L4 | | | OriGene Protein Over-expression Lysate for FOXD4L4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FOXD4L4 | | OriGene 3'-UTR Clone for FOXD4L4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXD4L4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXD4L4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FOXD4L4 | | OriGene Custom Protein Services for FOXD4L4 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FOXD4L4 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOXD4L4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXD4L4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXD4L4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXD4L4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXD4L4 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for FOXD4L4 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | FOXD4L4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXD4L4 |
|  |  |  | | | | Search ThermoFisher Antibodies for FOXD4L4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXD4L4 |
|
|
|
|
