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Aliases for FOXD4L4 Gene

Aliases for FOXD4L4 Gene

  • Forkhead Box D4-Like 4 2 3
  • Forkhead Box D4-Like 2 2 3
  • Myeloid Factor-Gamma 3 4
  • FOXD4-Like 4 3 4
  • FOXD4b 3 4
  • Winged Helix Transcription Factor Beta 3
  • Forkhead Box Protein D4b 3
  • Forkhead Box Protein D4B 4
  • Winged Helix Factor-1 3
  • BA460E7.2 3
  • FOXD4L2 3

External Ids for FOXD4L4 Gene

Previous HGNC Symbols for FOXD4L4 Gene

  • FOXD4L2

Previous GeneCards Identifiers for FOXD4L4 Gene

  • GC00U921578
  • GC09U900683
  • GC09M067938
  • GC09M069666
  • GC09M070427

Summaries for FOXD4L4 Gene

GeneCards Summary for FOXD4L4 Gene

FOXD4L4 (Forkhead Box D4-Like 4) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXE3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXD4L4 Gene

Genomics for FOXD4L4 Gene

Regulatory Elements for FOXD4L4 Gene

Genomic Location for FOXD4L4 Gene

Chromosome:
9
Start:
65,736,555 bp from pter
End:
65,738,784 bp from pter
Size:
2,230 bases
Orientation:
Plus strand

Genomic View for FOXD4L4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for FOXD4L4 Gene

Proteins for FOXD4L4 Gene

  • Protein details for FOXD4L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXT5-FX4L4_HUMAN
    Recommended name:
    Forkhead box protein D4-like 4
    Protein Accession:
    Q8WXT5
    Secondary Accessions:
    • Q5RIB4

    Protein attributes for FOXD4L4 Gene

    Size:
    416 amino acids
    Molecular mass:
    45892 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • 5 FOXD4-like proteins (FOXD4L2, FOXD4L3, FOXD4L4, FOXD4L5 and FOXD4L6) are encoded by a strongly repeated region of the 9q12 chromosome region. They are very similar and it is therefore difficult to provide a clear and unambiguous protein sequence. Our sequences are in agreement with HGNC nomenclature

neXtProt entry for FOXD4L4 Gene

Proteomics data for FOXD4L4 Gene at MOPED

Post-translational modifications for FOXD4L4 Gene

No Post-translational modifications

Other Protein References for FOXD4L4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXD4L4 Gene

Domains & Families for FOXD4L4 Gene

Protein Domains for FOXD4L4 Gene

Suggested Antigen Peptide Sequences for FOXD4L4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WXT5

UniProtKB/Swiss-Prot:

FX4L4_HUMAN :
  • Contains 1 fork-head DNA-binding domain.
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXD4L4: view

No data available for Gene Families for FOXD4L4 Gene

Function for FOXD4L4 Gene

Gene Ontology (GO) - Molecular Function for FOXD4L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003700 transcription factor activity, sequence-specific DNA binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXD4L4: view
genes like me logo Genes that share phenotypes with FOXD4L4: view

Animal Model Products

CRISPR Products

miRNA for FOXD4L4 Gene

miRTarBase miRNAs that target FOXD4L4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOXD4L4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FOXD4L4 Gene

Localization for FOXD4L4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXD4L4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXD4L4 Gene COMPARTMENTS Subcellular localization image for FOXD4L4 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for FOXD4L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with FOXD4L4: view

Pathways & Interactions for FOXD4L4 Gene

SuperPathways for FOXD4L4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXD4L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0009653 anatomical structure morphogenesis IBA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with FOXD4L4: view

No data available for Pathways by source and SIGNOR curated interactions for FOXD4L4 Gene

Drugs & Compounds for FOXD4L4 Gene

No Compound Related Data Available

Transcripts for FOXD4L4 Gene

mRNA/cDNA for FOXD4L4 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXD4L4 Gene

Forkhead box D4-like 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOXD4L4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXD4L4 Gene

No ASD Table

Relevant External Links for FOXD4L4 Gene

GeneLoc Exon Structure for
FOXD4L4
ECgene alternative splicing isoforms for
FOXD4L4

Expression for FOXD4L4 Gene

mRNA expression in normal human tissues for FOXD4L4 Gene

SOURCE GeneReport for Unigene cluster for FOXD4L4 Gene Hs.534644

genes like me logo Genes that share expression patterns with FOXD4L4: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FOXD4L4 Gene

Orthologs for FOXD4L4 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXD4L4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXD4L4 35
  • 98.22 (n)
  • 97.33 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 49 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii foxd5 36
  • 38 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta fd59A 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-130 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
ManyToMany
CSA.2032 36
  • 22 (a)
ManyToMany
Species with no ortholog for FOXD4L4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FOXD4L4 Gene

ENSEMBL:
Gene Tree for FOXD4L4 (if available)
TreeFam:
Gene Tree for FOXD4L4 (if available)

Paralogs for FOXD4L4 Gene

(12) SIMAP similar genes for FOXD4L4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXD4L4: view

Variants for FOXD4L4 Gene

Sequence variations from dbSNP and Humsavar for FOXD4L4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs3873970 -- 65,736,652(+) CATGT(C/T)GAGGT upstream-variant-2KB
rs4506290 -- 65,736,921(+) TAAAG(C/G)GGGGA upstream-variant-2KB
rs4537401 -- 65,736,635(-) TCCCT(C/T)CTGGA upstream-variant-2KB
rs4962023 -- 65,735,673(-) CACCA(A/C/T)GCCCA upstream-variant-2KB
rs4962024 -- 65,735,670(-) CACGC(C/G)CAGCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FOXD4L4 Gene

Variant ID Type Subtype PubMed ID
dgv8190n71 CNV Gain+Loss 21882294
esv2738445 CNV Deletion 23290073
dgv2362e1 CNV Complex 17122850
esv23416 CNV Gain 19812545
dgv2381e1 CNV Complex 17122850
dgv135n16 CNV Deletion 17901297
esv33449 CNV Loss 17666407
essv2899 CNV CNV 17122850
nsv469665 CNV Complex 16826518
dgv2383e1 CNV Complex 17122850
nsv471467 CNV Duplication 19718026
nsv8518 CNV Gain+Loss 18304495

Relevant External Links for FOXD4L4 Gene

HapMap Linkage Disequilibrium report
FOXD4L4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for FOXD4L4 Gene

Disorders for FOXD4L4 Gene

Relevant External Links for FOXD4L4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXD4L4
genes like me logo Genes that share disorders with FOXD4L4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXD4L4 Gene

Publications for FOXD4L4 Gene

  1. The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription. (PMID: 11238932) Yao J. … Stifani S. (Mol. Cell. Biol. 2001) 23 67
  2. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 67
  3. Diverse fates of paralogs following segmental duplication of telomeric genes. (PMID: 15233989) Wong A. … Ledbetter D.H. (Genomics 2004) 67
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 67
  5. FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines. (PMID: 12234674) Freyaldenhoven B.S. … Wielckens K. (Gene 2002) 67

Products for FOXD4L4 Gene

Sources for FOXD4L4 Gene

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