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Aliases for FOXD4L4 Gene

Aliases for FOXD4L4 Gene

  • Forkhead Box D4-Like 4 2 3 5
  • Forkhead Box Protein D4-Like 2 3 4
  • Forkhead Box D4-Like 2 2 3
  • Myeloid Factor-Gamma 3 4
  • FOXD4-Like 4 3 4
  • FOXD4L2 3 4
  • FOXD4b 3 4
  • Winged Helix Transcription Factor Beta 3
  • Forkhead Box Protein D4b 3
  • Forkhead Box Protein D4B 4
  • Winged Helix Factor-1 3
  • BA460E7.2 3

External Ids for FOXD4L4 Gene

Previous HGNC Symbols for FOXD4L4 Gene

  • FOXD4L2

Previous GeneCards Identifiers for FOXD4L4 Gene

  • GC00U921578
  • GC09U900683
  • GC09M067938
  • GC09M069666
  • GC09M070427

Summaries for FOXD4L4 Gene

GeneCards Summary for FOXD4L4 Gene

FOXD4L4 (Forkhead Box D4-Like 4) is a Protein Coding gene. Diseases associated with FOXD4L4 include Female Reproductive Organ Cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXE3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXD4L4 Gene

Genomics for FOXD4L4 Gene

Regulatory Elements for FOXD4L4 Gene

Enhancers for FOXD4L4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FOXD4L4 on UCSC Golden Path with GeneCards custom track

Genomic Location for FOXD4L4 Gene

65,736,555 bp from pter
65,738,784 bp from pter
2,230 bases
Plus strand

Genomic View for FOXD4L4 Gene

Genes around FOXD4L4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXD4L4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXD4L4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXD4L4 Gene

Proteins for FOXD4L4 Gene

  • Protein details for FOXD4L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Forkhead box protein D4-like 4
    Protein Accession:
    Secondary Accessions:
    • Q5RIB4
    • Q6VB85

    Protein attributes for FOXD4L4 Gene

    416 amino acids
    Molecular mass:
    45892 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXD4L4 Gene

Proteomics data for FOXD4L4 Gene at MOPED

Post-translational modifications for FOXD4L4 Gene

No Post-translational modifications

Other Protein References for FOXD4L4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXD4L4 Gene

Domains & Families for FOXD4L4 Gene

Protein Domains for FOXD4L4 Gene

Suggested Antigen Peptide Sequences for FOXD4L4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 fork-head DNA-binding domain.
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXD4L4: view

No data available for Gene Families for FOXD4L4 Gene

Function for FOXD4L4 Gene

Gene Ontology (GO) - Molecular Function for FOXD4L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with FOXD4L4: view
genes like me logo Genes that share phenotypes with FOXD4L4: view

Animal Model Products

CRISPR Products

miRNA for FOXD4L4 Gene

miRTarBase miRNAs that target FOXD4L4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FOXD4L4 Gene

Localization for FOXD4L4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXD4L4 Gene

Subcellular locations from

Jensen Localization Image for FOXD4L4 Gene COMPARTMENTS Subcellular localization image for FOXD4L4 gene
Compartment Confidence
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for FOXD4L4 Gene

Pathways & Interactions for FOXD4L4 Gene

SuperPathways for FOXD4L4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXD4L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with FOXD4L4: view

No data available for Pathways by source and SIGNOR curated interactions for FOXD4L4 Gene

Drugs & Compounds for FOXD4L4 Gene

No Compound Related Data Available

Transcripts for FOXD4L4 Gene

mRNA/cDNA for FOXD4L4 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXD4L4 Gene

Forkhead box D4-like 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXD4L4 Gene

No ASD Table

Relevant External Links for FOXD4L4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FOXD4L4 Gene

mRNA expression in normal human tissues for FOXD4L4 Gene

SOURCE GeneReport for Unigene cluster for FOXD4L4 Gene Hs.534644

genes like me logo Genes that share expression patterns with FOXD4L4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FOXD4L4 Gene

Orthologs for FOXD4L4 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXD4L4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FOXD4L4 35
  • 98.22 (n)
  • 97.33 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 49 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
(Danio rerio)
Actinopterygii foxd5 36
  • 38 (a)
fruit fly
(Drosophila melanogaster)
Insecta fd59A 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea unc-130 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
CSA.2032 36
  • 22 (a)
Species with no ortholog for FOXD4L4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FOXD4L4 Gene

Gene Tree for FOXD4L4 (if available)
Gene Tree for FOXD4L4 (if available)

Paralogs for FOXD4L4 Gene

(12) SIMAP similar genes for FOXD4L4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXD4L4: view

Variants for FOXD4L4 Gene

Sequence variations from dbSNP and Humsavar for FOXD4L4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs9330133 -- 65,735,376(-) gagcc(A/G)ccgtg upstream-variant-2KB
rs9695115 -- 65,735,246(-) TCACT(A/G)TCTGC upstream-variant-2KB
rs9695259 -- 65,735,372(-) cgccg(C/T)gcccg upstream-variant-2KB
rs9776748 -- 65,736,719(-) AAGGC(A/G)CATTT upstream-variant-2KB
rs10796795 -- 65,737,984(-) GTGCC(C/G)CGGCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FOXD4L4 Gene

Variant ID Type Subtype PubMed ID
dgv8190n71 CNV Gain+Loss 21882294
esv2738445 CNV Deletion 23290073
dgv2362e1 CNV Complex 17122850
esv23416 CNV Gain 19812545
dgv2381e1 CNV Complex 17122850
dgv135n16 CNV Deletion 17901297
esv33449 CNV Loss 17666407
essv2899 CNV CNV 17122850
nsv469665 CNV Complex 16826518
dgv2383e1 CNV Complex 17122850
nsv471467 CNV Duplication 19718026
nsv8518 CNV Gain+Loss 18304495

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for FOXD4L4 Gene

Disorders for FOXD4L4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FOXD4L4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
female reproductive organ cancer
  • female reproductive cancer
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FOXD4L4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FOXD4L4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOXD4L4 Gene

Publications for FOXD4L4 Gene

  1. Diverse fates of paralogs following segmental duplication of telomeric genes. (PMID: 15233989) Wong A. … Ledbetter D.H. (Genomics 2004) 3 4 67
  2. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  3. FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines. (PMID: 12234674) Freyaldenhoven B.S. … Wielckens K. (Gene 2002) 3
  4. Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. (PMID: 12421752) Fan Y. … Trask B.J. (Genome Res. 2002) 3
  5. The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription. (PMID: 11238932) Yao J. … Stifani S. (Mol. Cell. Biol. 2001) 23

Products for FOXD4L4 Gene

Sources for FOXD4L4 Gene