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Aliases for FOXD4L3 Gene

Aliases for FOXD4L3 Gene

  • Forkhead Box D4-Like 3 2 3
  • FOXD4-Like 3 3 4
  • Forkhead Box Protein D4-Like 3 3
  • Forkhead Box D4 Like 3 3
  • FOXD4-Like 2 3
  • FOXD4L2 3
  • FOXD6 3

External Ids for FOXD4L3 Gene

Previous GeneCards Identifiers for FOXD4L3 Gene

  • GC09U900383
  • GC09P066375
  • GC09M067936
  • GC09P068148
  • GC09P070107
  • GC09P070917

Summaries for FOXD4L3 Gene

GeneCards Summary for FOXD4L3 Gene

FOXD4L3 (Forkhead Box D4-Like 3) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXE3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXD4L3 Gene

Genomics for FOXD4L3 Gene

Regulatory Elements for FOXD4L3 Gene

Genomic Location for FOXD4L3 Gene

Chromosome:
9
Start:
68,302,867 bp from pter
End:
68,305,084 bp from pter
Size:
2,218 bases
Orientation:
Plus strand

Genomic View for FOXD4L3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXD4L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXD4L3 Gene

Proteins for FOXD4L3 Gene

  • Protein details for FOXD4L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6VB84-FX4L3_HUMAN
    Recommended name:
    Forkhead box protein D4-like 3
    Protein Accession:
    Q6VB84
    Secondary Accessions:
    • Q5JTX9

    Protein attributes for FOXD4L3 Gene

    Size:
    417 amino acids
    Molecular mass:
    45820 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • 5 FOXD4-like proteins (FOXD4L2, FOXD4L3, FOXD4L4, FOXD4L5 and FOXD4L6) are encoded by a strongly repeated region of the 9q12 chromosome region. They are very similar and it is therefore difficult to provide a clear and unambiguous protein sequence. Our sequences are in agreement with HGNC nomenclature

neXtProt entry for FOXD4L3 Gene

Proteomics data for FOXD4L3 Gene at MOPED

Post-translational modifications for FOXD4L3 Gene

No Post-translational modifications

Other Protein References for FOXD4L3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXD4L3 Gene

Domains & Families for FOXD4L3 Gene

Protein Domains for FOXD4L3 Gene

Suggested Antigen Peptide Sequences for FOXD4L3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6VB84

UniProtKB/Swiss-Prot:

FX4L3_HUMAN :
  • Contains 1 fork-head DNA-binding domain.
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXD4L3: view

No data available for Gene Families for FOXD4L3 Gene

Function for FOXD4L3 Gene

Gene Ontology (GO) - Molecular Function for FOXD4L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXD4L3: view

Phenotypes for FOXD4L3 Gene

GenomeRNAi human phenotypes for FOXD4L3:
genes like me logo Genes that share phenotypes with FOXD4L3: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOXD4L3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FOXD4L3 Gene

Localization for FOXD4L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXD4L3 Gene

Gene Ontology (GO) - Cellular Components for FOXD4L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with FOXD4L3: view

No data available for Subcellular locations from COMPARTMENTS for FOXD4L3 Gene

Pathways & Interactions for FOXD4L3 Gene

SuperPathways for FOXD4L3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXD4L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0009653 anatomical structure morphogenesis IBA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with FOXD4L3: view

No data available for Pathways by source and SIGNOR curated interactions for FOXD4L3 Gene

Drugs & Compounds for FOXD4L3 Gene

No Compound Related Data Available

Transcripts for FOXD4L3 Gene

mRNA/cDNA for FOXD4L3 Gene

(1) REFSEQ mRNAs :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOXD4L3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXD4L3 Gene

No ASD Table

Relevant External Links for FOXD4L3 Gene

GeneLoc Exon Structure for
FOXD4L3
ECgene alternative splicing isoforms for
FOXD4L3

Expression for FOXD4L3 Gene

mRNA expression in normal human tissues for FOXD4L3 Gene

mRNA differential expression in normal tissues according to GTEx for FOXD4L3 Gene

This gene is overexpressed in Brain - Hippocampus (x6.0), Brain - Cortex (x5.7), and Brain - Frontal Cortex (BA9) (x5.3).

Protein differential expression in normal tissues from HIPED for FOXD4L3 Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FOXD4L3 Gene



SOURCE GeneReport for Unigene cluster for FOXD4L3 Gene Hs.449471

genes like me logo Genes that share expression patterns with FOXD4L3: view

Protein tissue co-expression partners for FOXD4L3 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FOXD4L3 Gene

Orthologs for FOXD4L3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXD4L3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXD4L3 35
  • 99.04 (n)
  • 98.32 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 50 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii foxd5 36
  • 38 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta fd59A 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-130 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
ManyToMany
CSA.2032 36
  • 22 (a)
ManyToMany
Species with no ortholog for FOXD4L3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FOXD4L3 Gene

ENSEMBL:
Gene Tree for FOXD4L3 (if available)
TreeFam:
Gene Tree for FOXD4L3 (if available)

Paralogs for FOXD4L3 Gene

(13) SIMAP similar genes for FOXD4L3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXD4L3: view

Variants for FOXD4L3 Gene

Sequence variations from dbSNP and Humsavar for FOXD4L3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs2441589 -- 68,302,208(-) CCTCC(C/T)CAAGA upstream-variant-2KB
rs2482280 -- 68,301,149(-) TAGAA(A/G)TAACA upstream-variant-2KB
rs2921293 -- 68,303,646(+) CCCCC(A/G)CCCAG missense, reference
rs2989710 -- 68,303,981(-) ACAAA(C/T)TCTGC reference, missense
rs4745569 -- 68,305,206(+) GAGAT(A/C)AATTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FOXD4L3 Gene

Variant ID Type Subtype PubMed ID
essv2899 CNV CNV 17122850
dgv2383e1 CNV Complex 17122850
dgv8238n71 CNV Gain 21882294
dgv2384e1 CNV Complex 17122850
dgv2385e1 CNV Complex 17122850
nsv428218 CNV Loss 18775914
dgv8240n71 CNV Gain 21882294
nsv893404 CNV Gain 21882294
nsv831609 CNV Gain 17160897

Variation tolerance for FOXD4L3 Gene

Gene Damage Index Score: 3.89; 59.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXD4L3 Gene

HapMap Linkage Disequilibrium report
FOXD4L3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXD4L3 Gene

Disorders for FOXD4L3 Gene

Relevant External Links for FOXD4L3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXD4L3
genes like me logo Genes that share disorders with FOXD4L3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXD4L3 Gene

Publications for FOXD4L3 Gene

  1. Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. (PMID: 12421752) Fan Y. … Trask B.J. (Genome Res. 2002) 2 67
  2. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 67
  3. Diverse fates of paralogs following segmental duplication of telomeric genes. (PMID: 15233989) Wong A. … Ledbetter D.H. (Genomics 2004) 67
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 67
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for FOXD4L3 Gene

Sources for FOXD4L3 Gene

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