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Aliases for FOXD4L3 Gene

Aliases for FOXD4L3 Gene

  • Forkhead Box D4-Like 3 2 3
  • FOXD4-Like 3 3 4
  • Forkhead Box Protein D4-Like 3 3
  • Forkhead Box Protein D4-Like 2 3
  • Forkhead Box D4 Like 3 3
  • FOXD4-Like 2 3
  • FOXD4L2 3
  • FOXD6 3

External Ids for FOXD4L3 Gene

Previous GeneCards Identifiers for FOXD4L3 Gene

  • GC09U900383
  • GC09P066375
  • GC09M067936
  • GC09P068148
  • GC09P070107
  • GC09P070917

Summaries for FOXD4L3 Gene

GeneCards Summary for FOXD4L3 Gene

FOXD4L3 (Forkhead Box D4-Like 3) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding and double-stranded DNA binding. An important paralog of this gene is FOXE3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXD4L3 Gene

Genomics for FOXD4L3 Gene

Regulatory Elements for FOXD4L3 Gene

Genomic Location for FOXD4L3 Gene

Start:
68,302,867 bp from pter
End:
68,305,084 bp from pter
Size:
2,218 bases
Orientation:
Plus strand

Genomic View for FOXD4L3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXD4L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXD4L3 Gene

Proteins for FOXD4L3 Gene

  • Protein details for FOXD4L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6VB84-FX4L3_HUMAN
    Recommended name:
    Forkhead box protein D4-like 3
    Protein Accession:
    Q6VB84
    Secondary Accessions:
    • Q5JTX9

    Protein attributes for FOXD4L3 Gene

    Size:
    417 amino acids
    Molecular mass:
    45820 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • 5 FOXD4-like proteins (FOXD4L2, FOXD4L3, FOXD4L4, FOXD4L5 and FOXD4L6) are encoded by a strongly repeated region of the 9q12 chromosome region. They are very similar and it is therefore difficult to provide a clear and unambiguous protein sequence. Our sequences are in agreement with HGNC nomenclature

neXtProt entry for FOXD4L3 Gene

Proteomics data for FOXD4L3 Gene at MOPED

Post-translational modifications for FOXD4L3 Gene

No Post-translational modifications

Other Protein References for FOXD4L3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXD4L3 Gene

Domains for FOXD4L3 Gene

Protein Domains for FOXD4L3 Gene

Suggested Antigen Peptide Sequences for FOXD4L3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6VB84

UniProtKB/Swiss-Prot:

FX4L3_HUMAN :
  • Q6VB84
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXD4L3: view

No data available for Gene Families for FOXD4L3 Gene

Function for FOXD4L3 Gene

Gene Ontology (GO) - Molecular Function for FOXD4L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXD4L3: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FOXD4L3 Gene

Localization for FOXD4L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXD4L3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXD4L3 Gene COMPARTMENTS Subcellular localization image for FOXD4L3 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for FOXD4L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with FOXD4L3: view

Pathways for FOXD4L3 Gene

SuperPathways for FOXD4L3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXD4L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0009653 anatomical structure morphogenesis IBA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with FOXD4L3: view

No data available for Pathways by source for FOXD4L3 Gene

Transcripts for FOXD4L3 Gene

mRNA/cDNA for FOXD4L3 Gene

(8) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOXD4L3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FOXD4L3
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXD4L3 Gene

No ASD Table

Relevant External Links for FOXD4L3 Gene

GeneLoc Exon Structure for
FOXD4L3
ECgene alternative splicing isoforms for
FOXD4L3

Expression for FOXD4L3 Gene

mRNA expression in normal human tissues for FOXD4L3 Gene

mRNA differential expression in normal tissues according to GTEx for FOXD4L3 Gene

This gene is overexpressed in Brain - Hippocampus (6.0), Brain - Cortex (5.7), and Brain - Frontal Cortex (BA9) (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FOXD4L3 Gene

SOURCE GeneReport for Unigene cluster for FOXD4L3 Gene Hs.449471

genes like me logo Genes that share expressions with FOXD4L3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FOXD4L3 Gene

Orthologs for FOXD4L3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXD4L3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXD4L3 35
  • 99.04 (n)
  • 98.32 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 50 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii foxd5 36
  • 38 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta fd59A 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-130 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
ManyToMany
CSA.2032 36
  • 22 (a)
ManyToMany
Species with no ortholog for FOXD4L3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FOXD4L3 Gene

ENSEMBL:
Gene Tree for FOXD4L3 (if available)
TreeFam:
Gene Tree for FOXD4L3 (if available)

Paralogs for FOXD4L3 Gene

Selected SIMAP similar genes for FOXD4L3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXD4L3: view

Variants for FOXD4L3 Gene

Sequence variations from dbSNP and Humsavar for FOXD4L3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1133715 -- 68,305,303(-) GTTTT(A/G)AAAAT downstream-variant-500B
rs2255099 -- 68,305,239(-) TTTTC(C/T)CTGAG downstream-variant-500B
rs2482265 -- 68,305,316(-) TTTTA(A/G)GAAAT downstream-variant-500B
rs2482280 -- 68,301,149(-) TAGAA(A/G)TAACA upstream-variant-2KB
rs2777283 -- 68,305,346(-) GTTGC(A/C)AAGTC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FOXD4L3 Gene

Variant ID Type Subtype PubMed ID
essv2899 CNV CNV 17122850
dgv2383e1 CNV Complex 17122850
dgv8238n71 CNV Gain 21882294
dgv2384e1 CNV Complex 17122850
dgv2385e1 CNV Complex 17122850
nsv428218 CNV Loss 18775914
dgv8240n71 CNV Gain 21882294
nsv893404 CNV Gain 21882294
nsv831609 CNV Gain 17160897

Relevant External Links for FOXD4L3 Gene

HapMap Linkage Disequilibrium report
FOXD4L3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXD4L3 Gene

Disorders for FOXD4L3 Gene

No disorders were found for FOXD4L3 Gene.

No data available for UniProtKB/Swiss-Prot for FOXD4L3 Gene

Publications for FOXD4L3 Gene

  1. Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. (PMID: 12421752) Fan Y. … Trask B.J. (Genome Res. 2002) 2 3
  2. Diverse fates of paralogs following segmental duplication of telomeric genes. (PMID: 15233989) Wong A. … Ledbetter D.H. (Genomics 2004) 3 4
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FOXD4L3 Gene

Sources for FOXD4L3 Gene

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