FOXD4L2 Gene
protein-coding GIFtS: 34
GCID: GC09P042717
|
|
forkhead box D4-like 2
| |
Aliases
for FOXD4L2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Forkhead Box D4-Like 21 2 | | OTTHUMG000000667521 | | FOXD4-Like 23 |
Export aliases for FOXD4L2 gene to outside databasesPrevious GC identifers: GC09P066374 GC09U900605 GC09P068147 GC09M069667 GC09P042708 |
Summaries
for FOXD4L2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FOXD4L2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NT_078055.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FOXD4L2 gene promoter:
TBP Tal-1 p53 FOXD1 C/EBPalpha E47 GATA-1 GATA-2 CHOP-10 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for FOXD4L2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXD4L2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p12 Ensembl cytogenetic band: 9p12 HGNC cytogenetic band: 9p12FOXD4L2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P042717: view genomic region
(about GC identifiers)
Start:
|
42,717,234 bp from pter |
End:
|
42,720,342 bp from pter |
Size:
|
3,109 bases |
Orientation:
|
plus strand |
|
Proteins
for FOXD4L2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FX4L2_HUMAN, Q6VB85 (See
protein sequence)Recommended Name: Forkhead box protein D4-like 2 Size: 416 amino acids; 45892 Da
Subcellular location: Nucleus (By similarity)
Miscellaneous: 5 FOXD4-like proteins (FOXD4L2, FOXD4L3, FOXD4L4, FOXD4L5 and FOXD4L6) are encoded by a stronglyrepeated region of the 9q12 chromosome region. They are very similar and it is therefore difficult to provide a clearand unambiguous protein sequence. Our sequences are in agreement with HGNC nomenclatureExplore the universe of human proteins at neXtProt for FOXD4L2: NX_Q6VB85
FOXD4L2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001092749.1
ENSEMBL proteins: ENSP00000366814
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
-- | -- | | GO:0005667 | transcription factor complex |
-- | -- |
FOXD4L2 for ontologies About GeneDecksing
FOXD4L2 Antibody Products:
Assay Products for FOXD4L2: |
Protein
Domains /
Families
for FOXD4L2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FOXD4L2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6VB85ProtoNet protein and cluster: Q6VB85 UniProtKB/Swiss-Prot: FX4L2_HUMAN, Q6VB85Similarity: Contains 1 fork-head DNA-binding domain |
Function
for FOXD4L2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXD4L2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXD4L2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FOXD4L2 (NM_001099279) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOXD4L2 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FOXD4L2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXD4L2 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003690 | double-stranded DNA binding |
-- | -- | | GO:0003705 | RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity |
-- | -- | | GO:0008134 | transcription factor binding |
-- | -- | | GO:0008301 | DNA binding, bending |
-- | -- | | GO:0043565 | sequence-specific DNA binding |
-- | -- |
FOXD4L2 for ontologies About GeneDecksing
|
Pathways & Interactions
for FOXD4L2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOXD4L2
Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001755 | neural crest cell migration |
-- | -- | | GO:0007389 | pattern specification process |
-- | -- | | GO:0007422 | peripheral nervous system development |
-- | -- | | GO:0009790 | embryo development |
-- | -- | | GO:0030318 | melanocyte differentiation |
-- | -- |
FOXD4L2 for ontologies About GeneDecksing
|
Drugs & Compounds
for FOXD4L2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FOXD4L2
Search CenterWatch for drugs/clinical trials and news about FOXD4L2 / FX4L2
|
Transcripts
for FOXD4L2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FOXD4L2 gene: NM_001099279.1 Unigene Cluster for FOXD4L2: Forkhead box D4-like 2 Hs.712520 Unigene Representative Sequence: NM_0010992791 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000377590(uc004acn.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXD4L2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXD4L2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FOXD4L2 (NM_001099279) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOXD4L2 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FOXD4L2 |
GeneLoc Exon Structure
|
Expression
for FOXD4L2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FOXD4L2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACAGGATCA
About this image
See FOXD4L2 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.712520
SABiosciences Custom PCR Arrays for FOXD4L2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOXD4L2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FOXD4L2 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXD4L2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXD4L2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXD4L2 |
Orthologs
for FOXD4L2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FOXD4L2 gene from 4/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
54(a) |
1 → many |
2(49994144-49994639) |
zebrafish
(Danio rerio) |
Actinopterygii |
foxd56 |
forkhead box D5 |
31(a) |
1 → many |
8(31300987-31302137) |
fruit fly
(Drosophila melanogaster) |
Insecta |
fd59A6 |
forkhead domain 59A |
19(a) |
1 → many |
2R(18754044-18758229) |
worm
(Caenorhabditis elegans) |
Secernentea |
unc-1306 |
UNCoordinated family member (unc-130) |
25(a) |
possible ortholog |
II(11281922-11283890) |
ENSEMBL Gene Tree for FOXD4L2 (if available)
TreeFam Gene Tree for FOXD4L2 (if available) |
Paralogs
for FOXD4L2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FOXD4L2 gene
- FOXD4L41 2 FOXD4L51 2 FOXF12 FOXA22 FOXD4L12 FOXF22 FOXC22 FOXB12
- FOXI22 FOXE32 FOXC12 FOXQ12 FOXD4L32 FOXA32 FOXD12 FOXD32
- FOXE12 FOXL12 FOXA12 FOXB22 FOXI12 FOXD4L62 FOXS12 FOXD22
- FOXL22 FOXD42
12 SIMAP similar genes for FOXD4L2 using alignment to 1 protein entry: FX4L2_HUMAN:FOXD4L4 FOXD4L5 FOXD4L3 FOXD4L6 FOXD4L1 FOXD4
FOXE1 FOXD3 FOXL1 FOXD2 FOXE3 FOXD1
FOXD4L2 for paralogs About GeneDecksing
|
Genomic Variants
for FOXD4L2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FOXD4L2 (42717234 - 42720342 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 18 variations for FOXD4L2
15/17 CNVs (see all 17): 0302 7748 8628 96013 82978 31515 3770 22958 2819 82979 23255 3769 96010 96011 70600
1 Inversion: 37337 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for FOXD4L2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FOXD4L2 for disorders About GeneDecksing
OMIM gene information: 611085
OMIM disorders: --
3  diseases for FOXD4L2: About MalaCardsacne leukemia neuronitis
Export disorders for FOXD4L2 gene to outside databases
|
Publications
for FOXD4L2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FOXD4L2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FOXD4L2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. (PubMed id 12421752)1, 2, 3 Fan Y.... Trask B.J. (2002)
- Diverse fates of paralogs following segmental duplication of telomeric genes. (PubMed id 15233989)1, 2 Wong A....Ledbetter D.H. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
- FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines. (PubMed id 12234674)1 Freyaldenhoven B.S.... Wielckens K. (2002)
- Toward a complete human genome sequence. (PubMed id 9847074)1 Wilson R. (1998)
|
External Searches for FOXD4L2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FOXD4L2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FOXD4L2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FOXD4L2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FOXD4L2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FOXD4L2 gene:
Search GeneIP for patents involving FOXD4L2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FOXD4L2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FOXD4L2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOXD4L2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOXD4L2 | | | OriGene Protein Over-expression Lysate for FOXD4L2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FOXD4L2 | | OriGene 3'-UTR Clone for FOXD4L2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXD4L2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXD4L2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FOXD4L2 | | OriGene Custom Protein Services for FOXD4L2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FOXD4L2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOXD4L2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXD4L2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXD4L2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXD4L2 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXD4L2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for FOXD4L2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | FOXD4L2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXD4L2 |
|  |  |  | | | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FOXD4L2 |
|
|
|
|
