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Aliases for FOXD4L1 Gene

Aliases for FOXD4L1 Gene

  • Forkhead Box D4-Like 1 2 3
  • FOXD4-Like 1 3 4
  • Forkhead Box Protein D4-Like 1 3
  • Forkhead Box D4 Like 1 3
  • BA395L14.1 3
  • FOXD5 3

External Ids for FOXD4L1 Gene

Previous GeneCards Identifiers for FOXD4L1 Gene

  • GC02P112177
  • GC02P114163
  • GC02P114351
  • GC02P113972
  • GC02P114256

Summaries for FOXD4L1 Gene

Entrez Gene Summary for FOXD4L1 Gene

  • This gene is a member of the forkhead/winged-helix (FOX) family of transcription factors with highly conserved FOX DNA-binding domains. Members of the FOX family of transcription factors are regulators of embryogenesis and may play a role in human cancer. This gene lies in a region of chromosome 2 that surrounds the site where two ancestral chromosomes fused to form human chromosome 2. This region is duplicated elsewhere in the human genome, primarily in subtelomeric and pericentromeric locations, thus mutiple copies of this gene have been found. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXD4L1 Gene

FOXD4L1 (Forkhead Box D4-Like 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding and double-stranded DNA binding. An important paralog of this gene is FOXE3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXD4L1 Gene

Genomics for FOXD4L1 Gene

Regulatory Elements for FOXD4L1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FOXD4L1 Gene

113,498,665 bp from pter
113,501,155 bp from pter
2,491 bases
Plus strand

Genomic View for FOXD4L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXD4L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXD4L1 Gene

Proteins for FOXD4L1 Gene

  • Protein details for FOXD4L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Forkhead box protein D4-like 1
    Protein Accession:
    Secondary Accessions:
    • B3KWN1
    • B9EGF3

    Protein attributes for FOXD4L1 Gene

    408 amino acids
    Molecular mass:
    43610 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXD4L1 Gene

Proteomics data for FOXD4L1 Gene at MOPED

Post-translational modifications for FOXD4L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXD4L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXD4L1 Gene

Domains for FOXD4L1 Gene

Protein Domains for FOXD4L1 Gene

Suggested Antigen Peptide Sequences for FOXD4L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9NU39
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXD4L1: view

No data available for Gene Families for FOXD4L1 Gene

Function for FOXD4L1 Gene

Gene Ontology (GO) - Molecular Function for FOXD4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXD4L1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOXD4L1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FOXD4L1 Gene

Localization for FOXD4L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXD4L1 Gene

Subcellular locations from

Jensen Localization Image for FOXD4L1 Gene COMPARTMENTS Subcellular localization image for FOXD4L1 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for FOXD4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with FOXD4L1: view

Pathways for FOXD4L1 Gene

SuperPathways for FOXD4L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXD4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0009653 anatomical structure morphogenesis IBA --
genes like me logo Genes that share ontologies with FOXD4L1: view

No data available for Pathways by source for FOXD4L1 Gene

Transcripts for FOXD4L1 Gene

mRNA/cDNA for FOXD4L1 Gene

(5) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXD4L1 Gene

Forkhead box D4-like 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOXD4L1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXD4L1 Gene

No ASD Table

Relevant External Links for FOXD4L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FOXD4L1 Gene

mRNA expression in normal human tissues for FOXD4L1 Gene

mRNA differential expression in normal tissues according to GTEx for FOXD4L1 Gene

This gene is overexpressed in Testis (6.3), Brain - Cerebellar Hemisphere (5.6), and Brain - Cerebellum (4.1).

SOURCE GeneReport for Unigene cluster for FOXD4L1 Gene Hs.591554

genes like me logo Genes that share expressions with FOXD4L1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for FOXD4L1 Gene

Orthologs for FOXD4L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXD4L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FOXD4L1 35
  • 98.1 (n)
  • 95.79 (a)
(Bos Taurus)
Mammalia FOXD4L1 36
  • 62 (a)
(Mus musculus)
Mammalia Foxd4 36
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 48 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia foxd4l1.1 35
  • 57.56 (n)
  • 59.79 (a)
(Danio rerio)
Actinopterygii foxd5 36
  • 39 (a)
fruit fly
(Drosophila melanogaster)
Insecta fd59A 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea unc-130 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
CSA.2032 36
  • 23 (a)
Species with no ortholog for FOXD4L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FOXD4L1 Gene

Gene Tree for FOXD4L1 (if available)
Gene Tree for FOXD4L1 (if available)

Paralogs for FOXD4L1 Gene

Selected SIMAP similar genes for FOXD4L1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXD4L1: view

Variants for FOXD4L1 Gene

Sequence variations from dbSNP and Humsavar for FOXD4L1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1739559 -- 113,501,420(+) TTTTC(A/C/G)TCACC downstream-variant-500B
rs1739560 -- 113,501,422(+) TTCCT(C/T)ACCCC downstream-variant-500B
rs1739561 -- 113,501,446(+) AAACC(A/G)TTTGA downstream-variant-500B
rs2144270 -- 113,500,807(+) CTTCT(A/G)TGGCT utr-variant-3-prime
rs2357521 -- 113,497,939(-) ttttc(C/T)ttttt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FOXD4L1 Gene

Variant ID Type Subtype PubMed ID
esv380 CNV CNV 17122850
esv28287 CNV Gain 19812545
nsv834334 CNV Gain 17160897
nsv874902 CNV Gain 21882294
nsv874903 CNV Gain 21882294
essv901 CNV CNV 17122850
esv2675836 CNV Deletion 23128226

Relevant External Links for FOXD4L1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXD4L1 Gene

Disorders for FOXD4L1 Gene

No disorders were found for FOXD4L1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FOXD4L1 Gene

Publications for FOXD4L1 Gene

  1. Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. (PMID: 12421752) Fan Y. … Trask B.J. (Genome Res. 2002) 2 3 4
  2. Diverse fates of paralogs following segmental duplication of telomeric genes. (PMID: 15233989) Wong A. … Ledbetter D.H. (Genomics 2004) 2 3 4
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. (PMID: 7957066) Pierrou S. … Carlsson P. (EMBO J. 1994) 3

Products for FOXD4L1 Gene

Sources for FOXD4L1 Gene

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