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Aliases for FOXD4L1 Gene

Aliases for FOXD4L1 Gene

  • Forkhead Box D4-Like 1 2 3
  • FOXD4-Like 1 3 4
  • Forkhead Box Protein D4-Like 1 3
  • Forkhead Box D4 Like 1 3
  • BA395L14.1 3
  • FOXD5 3

External Ids for FOXD4L1 Gene

Summaries for FOXD4L1 Gene

Entrez Gene Summary for FOXD4L1 Gene

  • This gene is a member of the forkhead/winged-helix (FOX) family of transcription factors with highly conserved FOX DNA-binding domains. Members of the FOX family of transcription factors are regulators of embryogenesis and may play a role in human cancer. This gene lies in a region of chromosome 2 that surrounds the site where two ancestral chromosomes fused to form human chromosome 2. This region is duplicated elsewhere in the human genome, primarily in subtelomeric and pericentromeric locations, thus mutiple copies of this gene have been found. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXD4L1 Gene

FOXD4L1 (Forkhead Box D4-Like 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding and double-stranded DNA binding. An important paralog of this gene is FOXE3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXD4L1 Gene

Genomics for FOXD4L1 Gene

Genomic Location for FOXD4L1 Gene

Start:
113,498,665 bp from pter
End:
113,501,155 bp from pter
Size:
2,491 bases
Orientation:
Plus strand

Genomic View for FOXD4L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXD4L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXD4L1 Gene

Regulatory Elements for FOXD4L1 Gene

Proteins for FOXD4L1 Gene

  • Protein details for FOXD4L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NU39-FX4L1_HUMAN
    Recommended name:
    Forkhead box protein D4-like 1
    Protein Accession:
    Q9NU39
    Secondary Accessions:
    • B3KWN1
    • B9EGF3

    Protein attributes for FOXD4L1 Gene

    Size:
    408 amino acids
    Molecular mass:
    43610 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXD4L1 Gene

Proteomics data for FOXD4L1 Gene at MOPED

Post-translational modifications for FOXD4L1 Gene

No Post-translational modifications

Other Protein References for FOXD4L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXD4L1 Gene

Domains for FOXD4L1 Gene

Protein Domains for FOXD4L1 Gene

UniProtKB/Swiss-Prot:

FX4L1_HUMAN
Domain:
  • Contains 1 fork-head DNA-binding domain.:
    • Q9NU39
genes like me logo Genes that share domains with FOXD4L1: view

No data available for Gene Families for FOXD4L1 Gene

Function for FOXD4L1 Gene

Gene Ontology (GO) - Molecular Function for FOXD4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXD4L1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FOXD4L1 Gene

Localization for FOXD4L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXD4L1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXD4L1 Gene COMPARTMENTS Subcellular localization image for FOXD4L1 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for FOXD4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with FOXD4L1: view

Pathways for FOXD4L1 Gene

SuperPathways for FOXD4L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXD4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0009653 anatomical structure morphogenesis IBA --
genes like me logo Genes that share ontologies with FOXD4L1: view

No data available for Pathways by source for FOXD4L1 Gene

Transcripts for FOXD4L1 Gene

mRNA/cDNA for FOXD4L1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXD4L1 Gene

Forkhead box D4-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXD4L1 Gene

No ASD Table

Relevant External Links for FOXD4L1 Gene

GeneLoc Exon Structure for
FOXD4L1
ECgene alternative splicing isoforms for
FOXD4L1

Expression for FOXD4L1 Gene

mRNA expression in normal human tissues for FOXD4L1 Gene

mRNA differential expression in normal tissues according to GTEx for FOXD4L1 Gene

This gene is overexpressed in Testis (6.3), Brain - Cerebellar Hemisphere (5.6), and Brain - Cerebellum (4.1).

SOURCE GeneReport for Unigene cluster for FOXD4L1 Gene Hs.591554

genes like me logo Genes that share expressions with FOXD4L1: view

Orthologs for FOXD4L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXD4L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXD4L1 36
  • 98.1 (n)
  • 95.79 (a)
cow
(Bos Taurus)
Mammalia FOXD4L1 37
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxd4 37
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 48 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia foxd4l1.1 36
  • 57.56 (n)
  • 59.79 (a)
zebrafish
(Danio rerio)
Actinopterygii foxd5 37
  • 39 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta fd59A 37
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-130 37
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 22 (a)
ManyToMany
CSA.2032 37
  • 23 (a)
ManyToMany
Species with no ortholog for FOXD4L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FOXD4L1 Gene

ENSEMBL:
Gene Tree for FOXD4L1 (if available)
TreeFam:
Gene Tree for FOXD4L1 (if available)

Paralogs for FOXD4L1 Gene

Selected SIMAP similar genes for FOXD4L1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXD4L1: view

Variants for FOXD4L1 Gene

Sequence variations from dbSNP and Humsavar for FOXD4L1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1739559 -- 113,501,420(+) TTTTC(A/C/G)TCACC downstream-variant-500B
rs1739560 -- 113,501,422(+) TTCCT(C/T)ACCCC downstream-variant-500B
rs1739561 -- 113,501,446(+) AAACC(A/G)TTTGA downstream-variant-500B
rs2144270 -- 113,500,807(+) CTTCT(A/G)TGGCT utr-variant-3-prime
rs2357521 -- 113,497,939(-) ttttc(C/T)ttttt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FOXD4L1 Gene

Variant ID Type Subtype PubMed ID
esv380 CNV CNV 17122850
esv28287 CNV Gain 19812545
nsv834334 CNV Gain 17160897
nsv874902 CNV Gain 21882294
nsv874903 CNV Gain 21882294
essv901 CNV CNV 17122850
esv2675836 CNV Deletion 23128226

Relevant External Links for FOXD4L1 Gene

HapMap Linkage Disequilibrium report
FOXD4L1

Disorders for FOXD4L1 Gene

No disorders were found for FOXD4L1 Gene.

No data available for UniProtKB/Swiss-Prot for FOXD4L1 Gene

Publications for FOXD4L1 Gene

  1. Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. (PMID: 12421752) Fan Y. … Trask B.J. (Genome Res. 2002) 2 3 4
  2. Diverse fates of paralogs following segmental duplication of telomeric genes. (PMID: 15233989) Wong A. … Ledbetter D.H. (Genomics 2004) 2 3 4
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. (PMID: 7957066) Pierrou S. … Carlsson P. (EMBO J. 1994) 3

Products for FOXD4L1 Gene

Sources for FOXD4L1 Gene

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