FOXD4L1 Gene
protein-coding GIFtS: 40
GCID: GC02P114256
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|
forkhead box D4-like 1
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Aliases
for FOXD4L1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Forkhead Box D4-Like 11 2 | | FOXD51 2 | | FOXD4-Like 12 3 | | BA395L14.11 | | Forkhead Box D4 Like 12 | | Forkhead Box Protein D4-Like 12 |
Export aliases for FOXD4L1 gene to outside databasesPrevious GC identifers: GC02P112177 GC02P114163 GC02P114351 GC02P113972 |
Summaries
for FOXD4L1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FOXD4L1:
This gene is a member of the forkhead/winged-helix (FOX) family of transcription factors with highly conserved FOXDNA-binding domains. Members of the FOX family of transcription factors are regulators of embryogenesis and may play arole in human cancer. This gene lies in a region of chromosome 2 that surrounds the site where two ancestralchromosomes fused to form human chromosome 2. This region is duplicated elsewhere in the human genome, primarily insubtelomeric and pericentromeric locations, thus mutiple copies of this gene have been found. (provided by RefSeq, Jul2008)
|
Genomic Views
for FOXD4L1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022135.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FOXD4L1 gene promoter:
TBP C/EBPbeta p53 LCR-F1 GATA-1 GATA-2 Pax-3 CP2 FOXO4 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for FOXD4L1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXD4L1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q13 Ensembl cytogenetic band: 2q13 HGNC cytogenetic band: 2q14.1FOXD4L1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P114256: view genomic region
(about GC identifiers)
Start:
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114,256,661 bp from pter |
End:
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114,258,728 bp from pter |
Size:
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2,068 bases |
Orientation:
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plus strand |
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Proteins
for FOXD4L1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FX4L1_HUMAN, Q9NU39 (See
protein sequence)Recommended Name: Forkhead box protein D4-like 1 Size: 408 amino acids; 43610 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: B3KWN1 B9EGF3Explore the universe of human proteins at neXtProt for FOXD4L1: NX_Q9NU39
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NU39
FOXD4L1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036316.1
ENSEMBL proteins: ENSP00000302756
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
FOXD4L1 for ontologies About GeneDecksing
FOXD4L1 Antibody Products:
Assay Products for FOXD4L1: |
Protein
Domains /
Families
for FOXD4L1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FOXD4L1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NU39ProtoNet protein and cluster: Q9NU39 UniProtKB/Swiss-Prot: FX4L1_HUMAN, Q9NU39Similarity: Contains 1 fork-head DNA-binding domain |
Function
for FOXD4L1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXD4L1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXD4L1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXD4L1 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003690 | double-stranded DNA binding |
IBA | -- | | GO:0003705 | RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity |
IBA | -- | | GO:0008134 | transcription factor binding |
IBA | -- | | GO:0008301 | DNA binding, bending |
IBA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
FOXD4L1 for ontologies About GeneDecksing
|
Pathways & Interactions
for FOXD4L1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOXD4L1
Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001755 | neural crest cell migration |
IBA | -- | | GO:0007389 | pattern specification process |
IBA | -- | | GO:0007422 | peripheral nervous system development |
IBA | -- | | GO:0009790 | embryo development |
IBA | -- | | GO:0030318 | melanocyte differentiation |
IBA | -- |
FOXD4L1 for ontologies About GeneDecksing
|
Drugs & Compounds
for FOXD4L1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FOXD4L1
Search CenterWatch for drugs/clinical trials and news about FOXD4L1 / FX4L1
|
Transcripts
for FOXD4L1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FOXD4L1 gene: NM_012184.4 Unigene Cluster for FOXD4L1: Forkhead box D4-like 1 Hs.591554 [show with all ESTs]Unigene Representative Sequence: AK1253981 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000306507(uc002tjw.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXD4L1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXD4L1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FOXD4L1 (NM_012184) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOXD4L1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXD4L1 |
Additional cDNA sequence: AF452723.1 AK122950.1 AK125398.1 AY344639.1 BC136428.1 4 DOTS entries: DT.120985299 DT.101983633 DT.121174326 DT.436073 11 AceView cDNA sequences: AK125398 NM_012184 AF452723 BV190165 BV196387 BV196386 AY344639 AK122950 BV196388 CB856755 AI860024
GeneLoc Exon Structure
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Expression
for FOXD4L1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FOXD4L1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See FOXD4L1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FOXD4L1
SOURCE GeneReport for Unigene cluster: Hs.591554
SABiosciences Custom PCR Arrays for FOXD4L1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOXD4L1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FOXD4L1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXD4L1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXD4L1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXD4L1 |
Orthologs
for FOXD4L1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for FOXD4L1 gene from 4/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
54(a) |
1 → many |
2(49994144-49994639) |
zebrafish
(Danio rerio) |
Actinopterygii |
foxd56 |
forkhead box D5 |
32(a) |
1 → many |
8(31300987-31302137) |
fruit fly
(Drosophila melanogaster) |
Insecta |
fd59A6 |
forkhead domain 59A |
20(a) |
1 → many |
2R(18754044-18758229) |
worm
(Caenorhabditis elegans) |
Secernentea |
unc-1306 |
UNCoordinated family member (unc-130) |
25(a) |
possible ortholog |
II(11281922-11283890) |
ENSEMBL Gene Tree for FOXD4L1 (if available)
TreeFam Gene Tree for FOXD4L1 (if available) |
Paralogs
for FOXD4L1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FOXD4L1 gene
- FOXF12 FOXA22 FOXF22 FOXC22 FOXB12 FOXI22 FOXE32 FOXC12
- FOXD4L22 FOXQ12 FOXD4L32 FOXA32 FOXD12 FOXD32 FOXD4L52 FOXD4L42
- FOXE12 FOXL12 FOXA12 FOXB22 FOXI12 FOXD4L62 FOXS12 FOXL22
- FOXD22 FOXD42
10 SIMAP similar genes for FOXD4L1 using alignment to 1 protein entry: FX4L1_HUMAN:FOXD4L2 FOXD4L3 FOXD4L4 FOXD4L5 FOXD4L6 FOXD4
FOXD3 FOXE3 FOXC2 FOXD1
FOXD4L1 for paralogs About GeneDecksing
|
Genomic Variants
for FOXD4L1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FOXD4L1 (114256661 - 114258728 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for FOXD4L1
4 CNVs: 89901 78714 3386 68130 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOXD4L1 |
|
Disorders
/ Diseases
for FOXD4L1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FOXD4L1 for disorders About GeneDecksing
OMIM gene information: 611084
OMIM disorders: --
1  disease for FOXD4L1: About MalaCardsneuronitis
Export disorders for FOXD4L1 gene to outside databases
|
Publications
for FOXD4L1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FOXD4L1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FOXD4L1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Diverse fates of paralogs following segmental duplication of telomeric genes. (PubMed id 15233989)1, 2, 3 Wong A....Ledbetter D.H. (2004)
- Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. (PubMed id 12421752)1, 2, 3 Fan Y.... Trask B.J. (2002)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. (PubMed id 7957066)1 Pierrou S....Carlsson P. (1994)
|
External Searches for FOXD4L1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FOXD4L1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FOXD4L1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FOXD4L1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for FOXD4L1 gene:
Search GeneIP for patents involving FOXD4L1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FOXD4L1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | FOXD4L1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXD4L1 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXD4L1 |
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