Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FOXD4 Gene

Aliases for FOXD4 Gene

  • Forkhead Box D4 2 3 5
  • Forkhead-Related Transcription Factor 5 3 4
  • Forkhead-Related Protein FKHL9 3 4
  • Myeloid Factor-Alpha 3 4
  • FREAC-5 3 4
  • FOXD4A 3 4
  • FREAC5 3 4
  • FKHL9 3 4
  • Forkhead, Drosophila, Homolog-Like 9 3
  • Forkhead-Related Activator 5 3
  • Forkhead Box Protein D4 3

External Ids for FOXD4 Gene

Previous HGNC Symbols for FOXD4 Gene

  • FKHL9

Previous GeneCards Identifiers for FOXD4 Gene

  • GC09M000084
  • GC09M000106
  • GC09M000058

Summaries for FOXD4 Gene

Entrez Gene Summary for FOXD4 Gene

  • This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. Mutations in this gene are associated with a complex phenotype consisting of dilated cardiomyopathy, obsessive-compulsive disorders, and suicidality. [provided by RefSeq, Mar 2012]

GeneCards Summary for FOXD4 Gene

FOXD4 (Forkhead Box D4) is a Protein Coding gene. Diseases associated with FOXD4 include Cerebral Palsy and Dilated Cardiomyopathy. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXD4L4.

Gene Wiki entry for FOXD4 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXD4 Gene

Genomics for FOXD4 Gene

Regulatory Elements for FOXD4 Gene

Enhancers for FOXD4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F000468 0.4 ENCODE 10 -351.5 -351482 3.1 HDGF ARNT MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF48 YY1 SLC30A9 FOXD4 RPL12P25 KANK1 LOC105375945
GH09F000219 1 Ensembl ENCODE 9 -104.0 -103961 6.4 HDAC1 PKNOX1 TAL1 CEBPG FOSL1 GATA3 CTBP1 SCRT2 NR2F6 FOS CBWD1 LOC105375946 FOXD4 GC09M000225 C9orf66
GH09F000112 0.9 FANTOM5 Ensembl 7 +4.2 4167 2.8 SUZ12 BMI1 ZIC2 ZNF335 ZNF366 ZSCAN29 PRDM10 EZH2 RNF2 L3MBTL2 CBWD1 WASHC1 FOXD4 GC09P000118 LINC01388 PIR36916
GH09F000270 0.9 FANTOM5 ENCODE 5.8 -154.7 -154686 5.4 PKNOX1 ATF1 ARNT YY1 ELK1 CBX5 ZNF143 FOS JUNB TBX21 DOCK8 C9orf66 CBWD1 LOC105375946 WASHC1 FOXD4 GC09P000245
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FOXD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for FOXD4 Gene

Chromosome:
9
Start:
116,231 bp from pter
End:
118,417 bp from pter
Size:
2,187 bases
Orientation:
Minus strand

Genomic View for FOXD4 Gene

Genes around FOXD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXD4 Gene

Proteins for FOXD4 Gene

  • Protein details for FOXD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12950-FOXD4_HUMAN
    Recommended name:
    Forkhead box protein D4
    Protein Accession:
    Q12950
    Secondary Accessions:
    • B2RN05
    • B9EGL7
    • Q5VVK1
    • Q8WXT6

    Protein attributes for FOXD4 Gene

    Size:
    439 amino acids
    Molecular mass:
    47309 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXD4 Gene

Post-translational modifications for FOXD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXD4 Gene

Domains & Families for FOXD4 Gene

Gene Families for FOXD4 Gene

Protein Domains for FOXD4 Gene

Suggested Antigen Peptide Sequences for FOXD4 Gene

Graphical View of Domain Structure for InterPro Entry

Q12950

UniProtKB/Swiss-Prot:

FOXD4_HUMAN :
  • Contains 1 fork-head DNA-binding domain.
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXD4: view

Function for FOXD4 Gene

Molecular function for FOXD4 Gene

GENATLAS Biochemistry:
transcription factor-like 9,with a Drosophila homeo forkhead DNA binding domain homolog

Gene Ontology (GO) - Molecular Function for FOXD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 9325056
GO:0008301 DNA binding, bending ISS 7957066
GO:0043565 sequence-specific DNA binding ISS 7957066
genes like me logo Genes that share ontologies with FOXD4: view

Phenotypes for FOXD4 Gene

GenomeRNAi human phenotypes for FOXD4:
genes like me logo Genes that share phenotypes with FOXD4: view

Animal Model Products

miRNA for FOXD4 Gene

miRTarBase miRNAs that target FOXD4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FOXD4 Gene

Localization for FOXD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXD4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXD4 Gene COMPARTMENTS Subcellular localization image for FOXD4 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for FOXD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with FOXD4: view

Pathways & Interactions for FOXD4 Gene

SuperPathways for FOXD4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with FOXD4: view

No data available for Pathways by source and SIGNOR curated interactions for FOXD4 Gene

Transcripts for FOXD4 Gene

mRNA/cDNA for FOXD4 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXD4 Gene

Forkhead box D4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXD4 Gene

No ASD Table

Relevant External Links for FOXD4 Gene

GeneLoc Exon Structure for
FOXD4
ECgene alternative splicing isoforms for
FOXD4

Expression for FOXD4 Gene

mRNA expression in normal human tissues for FOXD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXD4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.1).

NURSA nuclear receptor signaling pathways regulating expression of FOXD4 Gene:

FOXD4

SOURCE GeneReport for Unigene cluster for FOXD4 Gene:

Hs.584759
genes like me logo Genes that share expression patterns with FOXD4: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FOXD4 Gene

Orthologs for FOXD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 96 (a)
OneToMany
-- 35
  • 95 (a)
OneToMany
FOXD4L6 34
  • 86.25 (n)
cow
(Bos Taurus)
Mammalia FOXD4L1 34
  • 80.6 (n)
rat
(Rattus norvegicus)
Mammalia Foxd4 34
  • 75.14 (n)
mouse
(Mus musculus)
Mammalia Foxd4 34 16
  • 68.27 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 49 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 65 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii foxd5 35
  • 37 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta fd59A 35
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-130 35
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
ManyToMany
CSA.2032 35
  • 23 (a)
ManyToMany
Species where no ortholog for FOXD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FOXD4 Gene

ENSEMBL:
Gene Tree for FOXD4 (if available)
TreeFam:
Gene Tree for FOXD4 (if available)

Paralogs for FOXD4 Gene

(11) SIMAP similar genes for FOXD4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FOXD4: view

Variants for FOXD4 Gene

Sequence variations from dbSNP and Humsavar for FOXD4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1055205 -- 115,968(-) TTCCT(C/T)ACCCC downstream-variant-500B, upstream-variant-2KB
rs1057585 -- 116,436(-) TTGGA(A/G)CTGGA utr-variant-3-prime
rs10959293 -- 117,720(+) ACTAA(A/T)GAAGG reference, missense
rs10959306 -- 117,934(+) GCAAC(C/G)CCGCC reference, synonymous-codon
rs10959405 -- 119,516(+) cctgc(A/G)agctc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FOXD4 Gene

Variant ID Type Subtype PubMed ID
dgv12447n54 CNV gain 21841781
dgv253e55 CNV gain 17911159
dgv254e55 CNV gain 17911159
dgv7343n100 CNV gain 25217958
dgv7344n100 CNV gain 25217958
dgv7345n100 CNV gain 25217958
dgv7346n100 CNV gain 25217958
dgv7347n100 CNV gain 25217958
dgv7348n100 CNV gain 25217958
esv2759654 CNV gain+loss 17122850
esv2764172 CNV gain+loss 21179565
esv27644 CNV gain 19812545
esv3891501 CNV gain 25118596
nsv1023234 CNV loss 25217958
nsv515505 CNV gain+loss 19592680
nsv612982 CNV gain 21841781
nsv612983 CNV gain 21841781
nsv8403 CNV gain+loss 18304495
nsv972637 CNV duplication 23825009

Variation tolerance for FOXD4 Gene

Residual Variation Intolerance Score: 92.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.90; 89.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXD4 Gene

Human Gene Mutation Database (HGMD)
FOXD4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXD4 Gene

Disorders for FOXD4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FOXD4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cerebral palsy
  • infantile cerebral palsy
dilated cardiomyopathy
  • congestive cardiomyopathy
obsessive-compulsive disorder
  • obsessive-compulsive disorder, protection against
- elite association - COSMIC cancer census association via MalaCards
Search FOXD4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FOXD4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXD4
genes like me logo Genes that share disorders with FOXD4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOXD4 Gene

Publications for FOXD4 Gene

  1. FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines. (PMID: 12234674) Freyaldenhoven B.S. … Wielckens K. (Gene 2002) 2 3 4 64
  2. Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. (PMID: 7957066) Pierrou S. … Carlsson P. (EMBO J. 1994) 2 3 4 64
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. (PMID: 12421752) Fan Y. … Trask B.J. (Genome Res. 2002) 3 4 64

Products for FOXD4 Gene

Sources for FOXD4 Gene

Content
Loading form....