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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FOXD4 Gene

protein-coding   GIFtS: 47
GCID: GC09M000116

Forkhead Box D4


(Previous symbol: FKHL9)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Forkhead Box D41 2     FREAC-52 3
FKHL91 2 3 5     FREAC52 3
Forkhead-Related Protein FKHL92 3     Forkhead Box Protein D42
Forkhead-Related Transcription Factor 52 3     Forkhead, Drosophila, Homolog-Like 92
Myeloid Factor-Alpha2 3     Forkhead-Related Activator 52
FOXD4A2 3     

External Ids:    HGNC: 38051   Entrez Gene: 22982   Ensembl: ENSG000001701227   OMIM: 6010925   UniProtKB: Q129503   

Export aliases for FOXD4 gene to outside databases

Previous GC identifers: GC09M000084 GC09M000106 GC09M000058


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FOXD4 Gene:
This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX
transcription factors play critical roles in the regulation of multiple processes including metabolism, cell
proliferation and gene expression during ontogenesis. Mutations in this gene are associated with a complex
phenotype consisting of dilated cardiomyopathy, obsessive-compulsive disorders, and suicidality. (provided by
RefSeq, Mar 2012)

GeneCards Summary for FOXD4 Gene: 
FOXD4 (forkhead box D4) is a protein-coding gene. Diseases associated with FOXD4 include obsessive-compulsive disorder, and dilated cardiomyopathy. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOXF1.

Gene Wiki entry for FOXD4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FOXD4 gene promoter:
         TBP   C/EBPbeta   LCR-F1   GATA-1   GATA-2   Pax-3   FOXO4   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOXD4 promoter sequence
   Search SABiosciences Chromatin IP Primers for FOXD4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.3   Ensembl cytogenetic band:  9p24.3   HGNC cytogenetic band: 9p24.3

FOXD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXD4 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M000116:  view genomic region     (about GC identifiers)

Start:
116,234 bp from pter      End:
118,417 bp from pter
Size:
2,184 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FOXD4_HUMAN, Q12950 (See protein sequence)
Recommended Name: Forkhead box protein D4  
Size: 439 amino acids; 47309 Da
Subcellular location: Nucleus
Secondary accessions: B2RN05 B9EGL7 Q5VVK1 Q8WXT6

Explore the universe of human proteins at neXtProt for FOXD4: NX_Q12950

Explore proteomics data for FOXD4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q12950

  • FOXD4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FOXD4 Protein Expression
    REFSEQ proteins: NP_997188.2  
    ENSEMBL proteins: 
     ENSP00000371940  

    Human Recombinant Protein Products for FOXD4: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for FOXD4 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--
    GO:0005667transcription factor complex IBA--
    GO:0005730NOT nucleolus IDA--

    FOXD4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FOX: Forkhead boxes

    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry Q12950

    ProtoNet protein and cluster: Q12950

    UniProtKB/Swiss-Prot: FOXD4_HUMAN, Q12950
    Similarity: Contains 1 fork-head DNA-binding domain


    FOXD4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for FOXD4:
    transcription factor-like 9,with a Drosophila homeo forkhead DNA binding domain homolog

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003690double-stranded DNA binding IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9325056
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IBA--
    GO:0008134transcription factor binding IBA--
    GO:0008301DNA binding, bending ISS7957066
         
    FOXD4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FOXD4 
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    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate FOXD4:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOXD4

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IBA--
    GO:0001658branching involved in ureteric bud morphogenesis IBA--
    GO:0001755neural crest cell migration IBA--
    GO:0001822kidney development IBA--
    GO:0006355regulation of transcription, DNA-dependent NAS--

    FOXD4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FOXD4

    Search CenterWatch for drugs/clinical trials and news about FOXD4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FOXD4 gene: 
    NM_207305.4  

    Unigene Cluster for FOXD4:

    Forkhead box D4
    Hs.584759  [show with all ESTs]
    Unigene Representative Sequence: BC089432
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000382500(uc003zfz.3)
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate FOXD4:
    hsa-miR-873
    SwitchGear 3'UTR luciferase reporter plasmidFOXD4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FOXD4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXD4
    Clone
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    OriGene ORF clones in mouse, rat for FOXD4
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                         Customized lentivirus expression plasmids for stable overexpression of FOXD4 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXD4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXD4

    Additional mRNA sequence: 

    AF452724.1 AY344640.1 BC089432.1 BC103886.2 BC136570.1 BC136571.1 U13223.1 

    1 DOTS entry:

    DT.436073 

    14 AceView cDNA sequences:

    U13223 AF452724 CF132229 AY344640 NM_207305 CA313252 BV206348 AI819034 
    AW451208 CB856755 CF139066 AI860024 AW151124 AA628485 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FOXD4 expression in normal human tissues (normalized intensities)      FOXD4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCCCCCTTC
    FOXD4 Expression
    About this image


    FOXD4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Lymph (Hematopoietic System)    fully expand to see all 2 entries
             lymph node ; non-germinal center cells   
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             kidney ; cells in tubules   

    See FOXD4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FOXD4

    SOURCE GeneReport for Unigene cluster: Hs.584759
        SABiosciences Custom PCR Arrays for FOXD4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXD4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FOXD4 gene from 4/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Foxd45 forkhead box D4   --   19 (19.86 cM) 24898965 
    zebrafish
    (Danio rerio)
    Actinopterygii foxd56
    forkhead box D5
    35(a)
    1 → many
    8(31300987-31302137)
    fruit fly
    (Drosophila melanogaster)
    Insecta fd59A6
    forkhead domain 59A
    22(a)
    1 → many
    2R(18754044-18758229)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-1301 Protein UNC-130 49.78(n)
    50.22(a)
      174721  NM_064010.2  NP_496411.1 


    ENSEMBL Gene Tree for FOXD4 (if available)
    TreeFam Gene Tree for FOXD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FOXD4 gene
    FOXF12  FOXA22  FOXF22  FOXD4L12  FOXC22  FOXI22  FOXB12  FOXE32  
    FOXC12  FOXD4L22  FOXD4L32  FOXA32  FOXD4L52  FOXD12  FOXD32  FOXD4L42  
    FOXL12  FOXA12  FOXE12  FOXB22  FOXI12  FOXD4L62  FOXS12  FOXD22  
    FOXL22  
    11 SIMAP similar genes for FOXD4 using alignment to 3 protein entries:     FOXD4_HUMAN (see all proteins):
    FOXD4L2    FOXD4L4    FOXD4L5    FOXD4L1    FOXD4L3    FOXD4L6
    FOXE1    FOXC1    FOXD3    FOXE3    FOXL2

    FOXD4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/205 SNPs in FOXD4 are shown (see all 205)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1499961151,2
    Cuntested1116962(+) TGCCCG/ACCCAG 2 /G syn11Minor allele frequency- A:0.00NA 3488
    rs94064391,2
    C--60902(+) ggaggA/Gttgta 1 -- us2k10--------
    rs1996738221,2
    C--60970(+) TTCATA/GGTAGC 1 -- us2k10--------
    rs22652991,2
    C--61082(+) ctaacA/Ggtcta 1 -- us2k10--------
    rs1894757251,2
    --61135(+) TTTATC/TTTTTG 1 -- us2k10--------
    rs2006146631,2
    --61151(+) TTTTT-/GTTGTT 1 -- us2k10--------
    rs1128469281,2
    C--61190(-) GAAAGA/GAGATC 1 -- us2k10--------
    rs1996469041,2
    C--61244(+) ACCGTA/GGATTG 1 -- us2k10--------
    rs1148195701,2
    C,F--61263(+) CTTTCC/TGACTT 1 -- us2k11Minor allele frequency- T:0.12WA 118
    rs1157533621,2
    F--61290(+) AGGGCC/TGTGAA 1 -- us2k11Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for FOXD4 (116234 - 118417 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for FOXD4 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv7989n71CNV Loss21882294
    nsv891939CNV Loss21882294
    nsv891943CNV Gain21882294
    esv27644CNV Gain19812545
    nsv891940CNV Gain21882294
    nsv891942CNV Gain21882294
    dgv254e55CNV Gain17911159
    dgv253e55CNV Gain17911159
    nsv515505CNV Gain+Loss19592680
    nsv8403CNV Gain+Loss18304495


    Human Gene Mutation Database (HGMD): FOXD4
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FOXD4
    DNA2.0 Custom Variant and Variant Library Synthesis for FOXD4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601092    OMIM disorders: --

    4 diseases for FOXD4:    About MalaCards
    obsessive-compulsive disorder    dilated cardiomyopathy    cerebritis    leukemia


    FOXD4 for disorders           About GeneDecksing


    Export disorders for FOXD4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FOXD4 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with FOXD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines. (PubMed id 12234674)1, 2, 3 Freyaldenhoven B.S.... Wielckens K. (2002)
    2. Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. (PubMed id 7957066)1, 2, 3 Pierrou S....Carlsson P. (1994)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. (PubMed id 12421752)1, 2 Fan Y.... Trask B.J. (2002)
    6. Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12). (PubMed id 8825632)1, 3 Larsson C....Carlsson P. (1995)
    7. Pure distal 9p deletion in a female infant with cerebr al palsy. (PubMed id 22876580)1 Chen C.P....Wang W. (2012)
    8. Inv dup del(9p): prenatal diagnosis and molecular cyto genetic characterization by fluorescence in situ hybridization and array compara tive genomic hybridization. (PubMed id 21482378)1 Chen C.P....Wang W. (2011)
    9. Maternally inherited partial monosomy 9p (pter -> p24. 1) and partial trisomy 20p (pter -> p12.1) characterized by microarray comparati ve genomic hybridization. (PubMed id 21948691)1 Freitas E.L....Gil-da-Silva-Lopes V.L. (2011)
    10. Update of human and mouse forkhead box (FOX) gene fami lies. (PubMed id 20650821)1 Jackson B.C....Vasiliou V. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2298 HGNC: 3805 AceView: FOXD4 Ensembl:ENSG00000170122 euGenes: HUgn2298
    ECgene: FOXD4 H-InvDB: FOXD4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FOXD4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FOXD4 gene:
    Search GeneIP for patents involving FOXD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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