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Aliases for FOXD3 Gene

Aliases for FOXD3 Gene

  • Forkhead Box D3 2 3 5
  • HNF3/FH Transcription Factor Genesis 3 4
  • HFH2 3 4
  • Genesis 3
  • VAMAS2 3
  • AIS1 3

External Ids for FOXD3 Gene

Previous GeneCards Identifiers for FOXD3 Gene

  • GC01P063723
  • GC01P062711
  • GC01P063146
  • GC01P063158
  • GC01P063500
  • GC01P063561
  • GC01P063788
  • GC01P061896

Summaries for FOXD3 Gene

Entrez Gene Summary for FOXD3 Gene

  • This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. [provided by RefSeq, Nov 2008]

GeneCards Summary for FOXD3 Gene

FOXD3 (Forkhead Box D3) is a Protein Coding gene. Diseases associated with FOXD3 include autoimmune disease 1 and vitiligo-associated autoimmune disease. Among its related pathways are Developmental Biology and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is FOXE3.

UniProtKB/Swiss-Prot for FOXD3 Gene

  • Binds to the consensus sequence 5-A[AT]T[AG]TTTGTTT-3 and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.

Gene Wiki entry for FOXD3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXD3 Gene

Genomics for FOXD3 Gene

Regulatory Elements for FOXD3 Gene

Promoters for FOXD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FOXD3 on UCSC Golden Path with GeneCards custom track

Genomic Location for FOXD3 Gene

Chromosome:
1
Start:
63,323,041 bp from pter
End:
63,325,126 bp from pter
Size:
2,086 bases
Orientation:
Plus strand

Genomic View for FOXD3 Gene

Genes around FOXD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXD3 Gene

Proteins for FOXD3 Gene

  • Protein details for FOXD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJU5-FOXD3_HUMAN
    Recommended name:
    Forkhead box protein D3
    Protein Accession:
    Q9UJU5
    Secondary Accessions:
    • Q9BYM2
    • Q9UDD1

    Protein attributes for FOXD3 Gene

    Size:
    478 amino acids
    Molecular mass:
    47630 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXD3 Gene

Proteomics data for FOXD3 Gene at MOPED

Post-translational modifications for FOXD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FOXD3 (FOXD3)

No data available for DME Specific Peptides for FOXD3 Gene

Domains & Families for FOXD3 Gene

Gene Families for FOXD3 Gene

Protein Domains for FOXD3 Gene

Suggested Antigen Peptide Sequences for FOXD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJU5

UniProtKB/Swiss-Prot:

FOXD3_HUMAN :
  • Contains 1 fork-head DNA-binding domain.
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXD3: view

Function for FOXD3 Gene

Molecular function for FOXD3 Gene

GENATLAS Biochemistry:
transcription factor-like,restrictively expressed in hematopoietic cells,with a Drosophila homeo fork head DNA binding domain,mouse hepatocyte nuclear factor 3 homolog
UniProtKB/Swiss-Prot Function:
Binds to the consensus sequence 5-A[AT]T[AG]TTTGTTT-3 and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.

Gene Ontology (GO) - Molecular Function for FOXD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 22306510
GO:0005515 protein binding IPI 11891324
genes like me logo Genes that share ontologies with FOXD3: view
genes like me logo Genes that share phenotypes with FOXD3: view

Human Phenotype Ontology for FOXD3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FOXD3 Gene

MGI Knock Outs for FOXD3:

Animal Model Products

  • Taconic Biosciences Mouse Models for FOXD3

miRNA for FOXD3 Gene

miRTarBase miRNAs that target FOXD3

Transcription Factor Targets for FOXD3 Gene

Selected GeneGlobe predicted Target genes for FOXD3

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for FOXD3 Gene

Localization for FOXD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXD3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXD3 Gene COMPARTMENTS Subcellular localization image for FOXD3 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for FOXD3 Gene

Pathways & Interactions for FOXD3 Gene

genes like me logo Genes that share pathways with FOXD3: view

Gene Ontology (GO) - Biological Process for FOXD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0001701 in utero embryonic development ISS --
GO:0030154 cell differentiation IBA --
GO:0035019 somatic stem cell population maintenance TAS --
genes like me logo Genes that share ontologies with FOXD3: view

No data available for SIGNOR curated interactions for FOXD3 Gene

Drugs & Compounds for FOXD3 Gene

No Compound Related Data Available

Transcripts for FOXD3 Gene

mRNA/cDNA for FOXD3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXD3 Gene

Forkhead box D3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXD3 Gene

No ASD Table

Relevant External Links for FOXD3 Gene

GeneLoc Exon Structure for
FOXD3
ECgene alternative splicing isoforms for
FOXD3

Expression for FOXD3 Gene

mRNA expression in normal human tissues for FOXD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXD3 Gene

This gene is overexpressed in Nerve - Tibial (x20.9) and Colon - Sigmoid (x4.1).

SOURCE GeneReport for Unigene cluster for FOXD3 Gene Hs.546573

mRNA Expression by UniProt/SwissProt for FOXD3 Gene

Q9UJU5-FOXD3_HUMAN
Tissue specificity: Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined.
genes like me logo Genes that share expression patterns with FOXD3: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for FOXD3 Gene

Orthologs for FOXD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXD3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOXD3 35
  • 89.26 (n)
  • 93.93 (a)
FOXD3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXD3 35
  • 91.01 (n)
  • 93.32 (a)
FOXD3 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxd3 35
  • 85.91 (n)
  • 86.91 (a)
Foxd3 16
Foxd3 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FOXD3 35
  • 99.37 (n)
  • 99.58 (a)
FOXD3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxd3 35
  • 87.41 (n)
  • 87.41 (a)
lizard
(Anolis carolinensis)
Reptilia FOXD3 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia foxd3 35
  • 76.85 (n)
  • 82.2 (a)
Str.11302 35
African clawed frog
(Xenopus laevis)
Amphibia foxd3b-A 35
zebrafish
(Danio rerio)
Actinopterygii foxd3 35
  • 74.98 (n)
  • 80.12 (a)
foxd3 36
  • 75 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3286 35
fruit fly
(Drosophila melanogaster)
Insecta fd59A 37
  • 88 (a)
fd96Cb 37
  • 45 (a)
fd59A 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-130 37
  • 77 (a)
unc-130 36
  • 35 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.311 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
ManyToMany
CSA.2032 36
  • 29 (a)
ManyToMany
Species with no ortholog for FOXD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FOXD3 Gene

ENSEMBL:
Gene Tree for FOXD3 (if available)
TreeFam:
Gene Tree for FOXD3 (if available)

Paralogs for FOXD3 Gene

(8) SIMAP similar genes for FOXD3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXD3: view

Variants for FOXD3 Gene

Structural Variations from Database of Genomic Variants (DGV) for FOXD3 Gene

Variant ID Type Subtype PubMed ID
nsv461672 CNV Gain 19166990
nsv470714 CNV Gain 18288195

Variation tolerance for FOXD3 Gene

Gene Damage Index Score: 4.26; 62.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXD3 Gene

HapMap Linkage Disequilibrium report
FOXD3
Human Gene Mutation Database (HGMD)
FOXD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for FOXD3 Gene

Disorders for FOXD3 Gene

MalaCards: The human disease database

(6) MalaCards diseases for FOXD3 Gene - From: OMIM, ClinVar, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
autoimmune disease 1
  • autoimmune disease, susceptibility to, 1
vitiligo-associated autoimmune disease
senile entropion
  • involutional entropion
vestibular nystagmus
  • nystagmus associated with disorder of the vestibular system
entropion
- elite association - COSMIC cancer census association via MalaCards
Search FOXD3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FOXD3_HUMAN
  • Autoimmune disease 1 (AIS1) [MIM:607836]: An autoimmune disorder characterized by the association of vitiligo with autoimmune thyroiditis (Hashimoto thyroiditis). {ECO:0000269 PubMed:16098053}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for FOXD3

Genetic Association Database (GAD)
FOXD3
Human Genome Epidemiology (HuGE) Navigator
FOXD3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXD3
genes like me logo Genes that share disorders with FOXD3: view

No data available for Genatlas for FOXD3 Gene

Publications for FOXD3 Gene

  1. Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells. (PMID: 8499623) Hromas R. … Klemsz M. (Blood 1993) 2 3 4 67
  2. Downregulation of the transcription factor, FoxD3, is associated with lymph node metastases in invasive ductal carcinomas of the breast. (PMID: 24551288) Zhao H. … Zhang Y. (Int J Clin Exp Pathol 2014) 3
  3. FoxD3 deficiency promotes breast cancer progression by induction of epithelial-mesenchymal transition. (PMID: 24632201) Chu T.L. … Ge J. (Biochem. Biophys. Res. Commun. 2014) 3
  4. FoxD3-regulated microRNA-137 suppresses tumour growth and metastasis in human hepatocellular carcinoma by targeting AKT2. (PMID: 24970808) Liu L.L. … Yun J.P. (Oncotarget 2014) 3
  5. FOXD3 modulates migration through direct transcriptional repression of TWIST1 in melanoma. (PMID: 25061102) Weiss M.B. … Aplin A.E. (Mol. Cancer Res. 2014) 3

Products for FOXD3 Gene

Sources for FOXD3 Gene

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