Aliases for FOXD3 Gene
External Ids for FOXD3 Gene
Previous GeneCards Identifiers for FOXD3 Gene
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. [provided by RefSeq, Nov 2008]
GeneCards Summary for FOXD3 Gene
FOXD3 (Forkhead Box D3) is a Protein Coding gene. Diseases associated with FOXD3 include autoimmune disease 1 and vitiligo-associated autoimmune disease. Among its related pathways are Wnt / Hedgehog / Notch and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is FOXE3.
UniProtKB/Swiss-Prot for FOXD3 Gene
Binds to the consensus sequence 5-A[AT]T[AG]TTTGTTT-3 and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.