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FOXD3 Gene

protein-coding   GIFtS: 56
GCID: GC01P063788

Forkhead Box D3

  See FOXD3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Forkhead Box D31 2     VAMAS22 5
HFH22 3     Genesis2
HNF3/FH Transcription Factor Genesis2 3     Forkhead Box Protein D32
AIS12 5     

External Ids:    HGNC: 38041   Entrez Gene: 270222   Ensembl: ENSG000001871407   OMIM: 6115395   UniProtKB: Q9UJU53   

Export aliases for FOXD3 gene to outside databases

Previous GC identifers: GC01P063723 GC01P062711 GC01P063146 GC01P063158 GC01P063500 GC01P063561 GC01P061896


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FOXD3 Gene:
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead
domain. Mutations in this gene cause autoimmune susceptibility 1. (provided by RefSeq, Nov 2008)

GeneCards Summary for FOXD3 Gene:
FOXD3 (forkhead box D3) is a protein-coding gene. Diseases associated with FOXD3 include entropion, and autoimmune disease 1. GO annotations related to this gene include double-stranded DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOXA2.

UniProtKB/Swiss-Prot: FOXD3_HUMAN, Q9UJU5
Function: Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also
acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors.
Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation.
Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of
embryogenesis

Gene Wiki entry for FOXD3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the FOXD3 gene promoter:
         E2F-4   E2F-3a   E2F-5   LHX3b/Lhx3b   CUTL1   E2F-2   LCR-F1   E2F   E2F-1   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOXD3 promoter sequence
   Search Chromatin IP Primers for FOXD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FOXD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31.3

FOXD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXD3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P063788:  view genomic region     (about GC identifiers)

Start:
63,788,730 bp from pter      End:
63,790,797 bp from pter
Size:
2,068 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FOXD3_HUMAN, Q9UJU5 (See protein sequence)
Recommended Name: Forkhead box protein D3  
Size: 478 amino acids; 47630 Da
Secondary accessions: Q9BYM2 Q9UDD1

Explore the universe of human proteins at neXtProt for FOXD3: NX_Q9UJU5

Explore proteomics data for FOXD3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FOXD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036315.1  
    ENSEMBL proteins: 
     ENSP00000360157  
    Reactome Protein details: Q9UJU5

    FOXD3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for FOXD3

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FOX: Forkhead boxes

    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry Q9UJU5

    ProtoNet protein and cluster: Q9UJU5

    UniProtKB/Swiss-Prot: FOXD3_HUMAN, Q9UJU5
    Similarity: Contains 1 fork-head DNA-binding domain


    Find genes that share domains with FOXD3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOXD3_HUMAN, Q9UJU5
    Function: Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also
    acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors.
    Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation.
    Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of
    embryogenesis

         Genatlas biochemistry entry for FOXD3:
    transcription factor-like,restrictively expressed in hematopoietic cells,with a Drosophila homeo fork head DNA
    binding domain,mouse hepatocyte nuclear factor 3 homolog

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding IDA--
    GO:0001227RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA--
    GO:0003677DNA binding ----
    GO:0003690double-stranded DNA binding IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity ISS--
         
    Find genes that share ontologies with FOXD3           About GenesLikeMe


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Foxd3):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     mortality/aging  nervous system  respiratory system  skeleton  vision/eye 

    Find genes that share phenotypes with FOXD3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Foxd3tm1Lby for FOXD3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FOXD3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FOXD3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FOXD3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FOXD3

    miRNA
    Products:
        
    miRTarBase miRNAs that target FOXD3:
    hsa-mir-335-5p (MIRT017622)

    Block miRNA regulation of human, mouse, rat FOXD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FOXD3 (see all 24):
    hsa-miR-520d-5p hsa-miR-374a hsa-miR-410 hsa-miR-548a-3p hsa-miR-548x hsa-miR-3613-3p hsa-miR-4330 hsa-miR-3143
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FOXD3

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for FOXD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FOXD3 (NM_012183)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXD3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXD3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FOXD3_HUMAN, Q9UJU5: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IDA--
    GO:0005667transcription factor complex IBA--

    Find genes that share ontologies with FOXD3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FOXD3 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    2Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway and Pluripotency0.55
    3Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    4Transcriptional Regulatory Network in Embryonic Stem Cell
    Transcriptional Regulatory Network in Embryonic Stem Cell
    5Oct4 in Mammalian ESC Pluripotency
    Oct4 in Mammalian ESC Pluripotency


    Find genes that share SuperPaths with FOXD3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FOXD3
        Transcriptional Regulatory Network in Embryonic Stem Cell
    Oct4 in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency

    1 Cell Signaling Technology (CST) Pathway for FOXD3
        Wnt / Hedgehog / Notch

    2 BioSystems Pathways for FOXD3
        Wnt Signaling Pathway and Pluripotency
    Neural Crest Differentiation

    1 Reactome Pathway for FOXD3
        POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation


        Pathway & Disease-focused RT2 Profiler PCR Arrays including FOXD3: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Notch Signaling Targets in human mouse rat
              Cell Lineage Identification in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FOXD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for FOXD3 (Q9UJU51, 3 ENSP000003601574) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206454Q018601, 3EBI-475674,EBI-475687 I2D: score=2 
    ENSG00000229094Q018601, 3EBI-475674,EBI-475687 I2D: score=2 
    ENSG00000230336Q018601, 3EBI-475674,EBI-475687 I2D: score=2 
    ENSG00000233911Q018601, 3EBI-475674,EBI-475687 I2D: score=2 
    ENSG00000235068Q018601, 3EBI-475674,EBI-475687 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0001658branching involved in ureteric bud morphogenesis IBA--
    GO:0001701in utero embryonic development ISS--
    GO:0001755neural crest cell migration IBA--
    GO:0001822kidney development IBA--

    Find genes that share ontologies with FOXD3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FOXD3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FOXD3 gene: 
    NM_012183.2  

    Unigene Cluster for FOXD3:

    Forkhead box D3
    Hs.546573  [show with all ESTs]
    Unigene Representative Sequence: NM_012183
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000371116(uc001dax.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat FOXD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FOXD3 (see all 24):
    hsa-miR-520d-5p hsa-miR-374a hsa-miR-410 hsa-miR-548a-3p hsa-miR-548x hsa-miR-3613-3p hsa-miR-4330 hsa-miR-3143
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      QuantiTect SYBR Green Assays in human, mouse, rat FOXD3
      QuantiFast Probe-based Assays in human, mouse, rat FOXD3

    Additional mRNA sequence: 

    AF086235.1 L12142.1 

    2 DOTS entries:

    DT.95176026  DT.65287892 

    1 AceView cDNA sequence:

    NM_012183 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FOXD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FOXD3 Expression
    About this image


    FOXD3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 8 entries
             Cranial Neural Crest Cells Cranial Neural Crest
             Neural crest-like cells
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 3 entries
             Mesencephalic Neural Crest Cells Prechordal Mesenchyme
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 6 entries
             Human embryonic stem cells (family)
     
     Neural Ectoderm (Nervous System)
             Neural Crest Cells Neural Plate Border
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
    FOXD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FOXD3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.546573

    UniProtKB/Swiss-Prot: FOXD3_HUMAN, Q9UJU5
    Tissue specificity: Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines,
    but not in any other cell lines or normal tissues examined

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FOXD3: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Notch Signaling Targets in human mouse rat
              Cell Lineage Identification in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat FOXD3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FOXD3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Foxd31 , 5 forkhead box D31, 5 85.91(n)1
    86.91(a)1
      4 (45.71 cM)5
    152211  NM_010425.31  NP_034555.31 
     996562995 
    lizard
    (Anolis carolinensis)
    Reptilia FOXD36
    forkhead box D3
    71(a)
    1 ↔ 1
    4(99388059-99389078)
    African clawed frog
    (Xenopus laevis)
    Amphibia foxd3b-A2 winged helix transcription factor 76.16(n)    AJ298866.1 
    zebrafish
    (Danio rerio)
    Actinopterygii foxd32 forkhead box D3 77.11(n)   30548  AF052249.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fd59A3 embryonic morphogenesis transcription
    factor
    88(a)
    (best of 2)
      59B4   --
    worm
    (Caenorhabditis elegans)
    Secernentea unc-1303 fork head domain protein 77(a)   II(11281899-11283574)   --


    ENSEMBL Gene Tree for FOXD3 (if available)
    TreeFam Gene Tree for FOXD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FOXD3 gene
    FOXA22  FOXD4L12  FOXC22  FOXI22  FOXB12  FOXE32  FOXC12  FOXD4L22  
    FOXD4L32  FOXA32  FOXD4L52  FOXD12  FOXD4L42  FOXA12  FOXE12  FOXL12  
    FOXB22  FOXI12  FOXD4L62  FOXS12  FOXD22  FOXL22  FOXD42  
    8 SIMAP similar genes for FOXD3 using alignment to 1 protein entry:     FOXD3_HUMAN:
    FOXD4L2    FOXD4L4    FOXD4L5    FOXE1    FOXD4    FOXD4L1
    FOXD4L3    FOXD4L6

    Find genes that share paralogs with FOXD3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    7 SNPs for FOXD3    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs615453601,2
    C--63790993(+) TTTTT-/TCTTTT 1 -- ds50010--------
    rs1808523461,2
    C--63863892(+) GAGACA/GTTGGG 1 -- ut310--------
    rs1384438961,2
    C--63863997(+) ATGTTA/GTTCCA 1 -- ut310--------
    rs120719191,2
    C--63864017(+) ACACAA/GCTTTG 1 -- ut31 ese30--------
    rs1861031741,2
    --63864388(+) TTTTTA/TAAAAA 1 -- ds50010--------
    rs357149331,2
    ----63864046(+) CCCAG-/TCCTAG 1 -- ds50010--------
    rs3772535141,2
    ----63864172(+) ATTCAC/TATTTG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for FOXD3 (63788730 - 63790797 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FOXD3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv461672CNV Gain19166990
    nsv470714CNV Gain18288195

    Human Gene Mutation Database (HGMD): FOXD3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FOXD3
    DNA2.0 Custom Variant and Variant Library Synthesis for FOXD3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611539   
    OMIM disorders: 607836  
    UniProtKB/Swiss-Prot: FOXD3_HUMAN, Q9UJU5
  • Autoimmune disease 1 (AIS1) [MIM:607836]: An autoimmune disorder characterized by the association of
    vitiligo with autoimmune thyroiditis (Hashimoto thyroiditis). Note=Disease susceptibility is associated with
    variations affecting the gene represented in this entry

  • 4 diseases for FOXD3:    
    About MalaCards
    entropion    autoimmune disease 1    vestibular nystagmus    chronic myeloid leukemia

    2 diseases from the University of Copenhagen DISEASES database for FOXD3:
    Entropion     Vestibular nystagmus

    Find genes that share disorders with FOXD3           About GenesLikeMe

    Genetic Association Database (GAD): FOXD3
    Human Genome Epidemiology (HuGE) Navigator: FOXD3 (2 documents)

    Export disorders for FOXD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FOXD3 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with FOXD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells. (PubMed id 8499623)1, 2, 3 Hromas R.... Klemsz M. (Blood 1993)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. Candidate functional promoter variant in the FOXD3 melanoblast developmental regulator gene in autosomal dominant vitiligo. (PubMed id 16098053)1, 2 Alkhateeb A.... Spritz R.A. (J. Invest. Dermatol. 2005)
    4. The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression. (PubMed id 11891324)1, 2 Guo Y.... Hromas R. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Neural crest and Schwann cell progenitor-derived melanocytes are two spatially segregated populations similarly regulated by Foxd3. (PubMed id 23858437)1 Nitzan E....Kalcheim C. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    6. Helicobacter pylori causes epigenetic dysregulation of FOXD3 to promote gastric carcinogenesis. (PubMed id 23058321)1 Cheng A.S....Chan F.K. (Gastroenterology 2013)
    7. Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3. (PubMed id 23543055)1 Abel E.V....Aplin A.E. (J. Clin. Invest. 2013)
    8. Modulation of FOXD3 activity in human embryonic stem cells directs pluripotency and paraxial mesoderm fates. (PubMed id 22887036)1 Arduini B.L. and Brivanlou A.H. (Stem Cells 2012)
    9. Analysis of FOXD3 sequence variation in human ocular disease. (PubMed id 22815627)1 Kloss B.A....Semina E.V. (Mol. Vis. 2012)
    10. FOXD3 regulates migration properties and Rnd3 expression in melanoma cells. (PubMed id 21478267)1 Katiyar P. and Aplin A.E. (Mol. Cancer Res. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27022 HGNC: 3804 AceView: FOXD3 Ensembl:ENSG00000187140 euGenes: HUgn27022
    ECgene: FOXD3 H-InvDB: FOXD3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FOXD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FOXD3 gene:
    Search GeneIP for patents involving FOXD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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