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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FOXD3 Gene

protein-coding   GIFtS: 55
GCID: GC01P063788

Forkhead Box D3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Forkhead Box D31 2     Genesis2
HFH22 3     VAMAS22
HNF3/FH Transcription Factor Genesis2 3     Forkhead Box Protein D32
AIS12 5     

External Ids:    HGNC: 38041   Entrez Gene: 270222   Ensembl: ENSG000001871407   OMIM: 6115395   UniProtKB: Q9UJU53   

Export aliases for FOXD3 gene to outside databases

Previous GC identifers: GC01P063723 GC01P062711 GC01P063146 GC01P063158 GC01P063500 GC01P063561 GC01P061896


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FOXD3 Gene:
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead
domain. Mutations in this gene cause autoimmune susceptibility 1. (provided by RefSeq, Nov 2008)

GeneCards Summary for FOXD3 Gene: 
FOXD3 (forkhead box D3) is a protein-coding gene. Diseases associated with FOXD3 include senile entropion, and autoimmune disease 1, and among its related super-pathways are GSK3 Signaling and Wnt Signaling Pathway. GO annotations related to this gene include double-stranded DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOXF1.

UniProtKB/Swiss-Prot: FOXD3_HUMAN, Q9UJU5
Function: Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also
acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors.
Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation.
Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of
embryogenesis

Gene Wiki entry for FOXD3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FOXD3 gene promoter:
         E2F-4   E2F-3a   E2F-5   LHX3b/Lhx3b   CUTL1   E2F-2   LCR-F1   E2F   E2F-1   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOXD3 promoter sequence
   Search SABiosciences Chromatin IP Primers for FOXD3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31.3

FOXD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXD3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P063788:  view genomic region     (about GC identifiers)

Start:
63,788,730 bp from pter      End:
63,790,797 bp from pter
Size:
2,068 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FOXD3_HUMAN, Q9UJU5 (See protein sequence)
Recommended Name: Forkhead box protein D3  
Size: 478 amino acids; 47630 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q9BYM2 Q9UDD1

Explore the universe of human proteins at neXtProt for FOXD3: NX_Q9UJU5

Explore proteomics data for FOXD3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UJU5

  • FOXD3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FOXD3 Protein Expression
    REFSEQ proteins: NP_036315.1  
    ENSEMBL proteins: 
     ENSP00000360157  

    Human Recombinant Protein Products for FOXD3: 
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    Novus Biologicals FOXD3 Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FOXD3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IDA--
    GO:0005667transcription factor complex IBA--

    FOXD3 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for FOXD3 
    Cloud-Clone Corp. CLIAs for FOXD3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FOX: Forkhead boxes

    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry Q9UJU5

    ProtoNet protein and cluster: Q9UJU5

    UniProtKB/Swiss-Prot: FOXD3_HUMAN, Q9UJU5
    Similarity: Contains 1 fork-head DNA-binding domain


    FOXD3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOXD3_HUMAN, Q9UJU5
    Function: Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also
    acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors.
    Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation.
    Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of
    embryogenesis

         Genatlas biochemistry entry for FOXD3:
    transcription factor-like,restrictively expressed in hematopoietic cells,with a Drosophila homeo fork head DNA
    binding domain,mouse hepatocyte nuclear factor 3 homolog

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding IDA--
    GO:0001227RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA--
    GO:0003677DNA binding ----
    GO:0003690double-stranded DNA binding IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity ISS--
         
    FOXD3 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Foxd3):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     mortality/aging  nervous system  respiratory system  skeleton  vision/eye 

    FOXD3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Foxd3tm1Lby for FOXD3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FOXD3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FOXD3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FOXD3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FOXD3 

    10/538 SABiosciences Target genes for FOXD3 (see all 538):
    ABCB7 ABCC2 ACAT2 ACOXL ACRBP ACSS3 ADAMTS20 ADAMTSL2 AFAP1L1 AGFG1

    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXD3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FOXD3 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    2Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency0.55
    3Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    4Oct4 in Mammalian ESC Pluripotency
    Oct4 in Mammalian ESC Pluripotency
    5Neural Crest Differentiation
    Neural Crest Differentiation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FOXD3
        Transcriptional Regulatory Network in Embryonic Stem Cell
    Oct4 in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency

    1 Cell Signaling Technology (CST) Pathway for FOXD3
        Wnt / Hedgehog / Notch

    2 BioSystems Pathways for FOXD3
        Wnt Signaling Pathway and Pluripotency
    Neural Crest Differentiation



    FOXD3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FOXD3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/7 Interacting proteins for FOXD3 (Q9UJU51, 3 ENSP000003601574) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206454Q018601, 3EBI-475674,EBI-475687 I2D: score=2 
    ENSG00000229094Q018601, 3EBI-475674,EBI-475687 I2D: score=2 
    ENSG00000230336Q018601, 3EBI-475674,EBI-475687 I2D: score=2 
    ENSG00000233911Q018601, 3EBI-475674,EBI-475687 I2D: score=2 
    ENSG00000235068Q018601, 3EBI-475674,EBI-475687 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0001658branching involved in ureteric bud morphogenesis IBA--
    GO:0001701in utero embryonic development ISS--
    GO:0001755neural crest cell migration IBA--
    GO:0001822kidney development IBA--

    FOXD3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FOXD3

    Search CenterWatch for drugs/clinical trials and news about FOXD3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FOXD3 gene: 
    NM_012183.2  

    Unigene Cluster for FOXD3:

    Forkhead box D3
    Hs.546573  [show with all ESTs]
    Unigene Representative Sequence: NM_012183
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000371116(uc001dax.2)
    miRNA
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    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXD3 (see all 24):
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    Additional mRNA sequence: 

    AF086235.1 L12142.1 

    2 DOTS entries:

    DT.95176026  DT.65287892 

    1 AceView cDNA sequence:

    NM_012183 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FOXD3 expression in normal human tissues (normalized intensities)      FOXD3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FOXD3 Expression
    About this image


    FOXD3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/19 selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
             ganglion/cranial   
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 6 entries
             Cranial Neural Crest Cells Cranial Neural Crest
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 5 entries
             HSF-1 (UC01)
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 3 entries
             Schwann Precursor Cells Peripheral Nerve Domain
             dorsal root ganglia   

    See FOXD3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FOXD3

    SOURCE GeneReport for Unigene cluster: Hs.546573

    UniProtKB/Swiss-Prot: FOXD3_HUMAN, Q9UJU5
    Tissue specificity: Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines,
    but not in any other cell lines or normal tissues examined

        SABiosciences Expression via Pathway-Focused PCR Arrays including FOXD3: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Notch Signaling Targets in human mouse rat
              Cell Lineage Identification in human mouse rat
              Embryonic Stem Cells in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FOXD3 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Foxd31 , 5 forkhead box D31, 5 89.34(n)1
    92.92(a)1
      4 (45.71 cM)5
    152211  NM_010425.31  NP_034555.31 
     996562995 
    lizard
    (Anolis carolinensis)
    Reptilia FOXD36
    Uncharacterized protein
    69(a)
    1 ↔ 1
    4(99388059-99389078)
    African clawed frog
    (Xenopus laevis)
    Amphibia foxd3b-A2 winged helix transcription factor 76.16(n)    AJ298866.1 
    zebrafish
    (Danio rerio)
    Actinopterygii foxd32 forkhead box D3 77.11(n)   30548  AF052249.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fd59A3 embryonic morphogenesis transcription
    factor
    88(a)
    (best of 2)
      59B4   --
    worm
    (Caenorhabditis elegans)
    Secernentea unc-1303 fork head domain protein 77(a)   II(11281899-11283574)   --


    ENSEMBL Gene Tree for FOXD3 (if available)
    TreeFam Gene Tree for FOXD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FOXD3 gene
    FOXF12  FOXA22  FOXF22  FOXD4L12  FOXC22  FOXI22  FOXB12  FOXE32  
    FOXC12  FOXD4L22  FOXD4L32  FOXA32  FOXD4L52  FOXD12  FOXD4L42  FOXL12  
    FOXA12  FOXE12  FOXB22  FOXI12  FOXD4L62  FOXS12  FOXD22  FOXL22  
    FOXD42  
    8 SIMAP similar genes for FOXD3 using alignment to 1 protein entry:     FOXD3_HUMAN:
    FOXD4L2    FOXD4L4    FOXD4L5    FOXE1    FOXD4    FOXD4L1
    FOXD4L3    FOXD4L6

    FOXD3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    7 SNPs in FOXD3 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs615453601,2
    C--63790993(+) TTTTT-/TCTTTT 1 -- ds50010--------
    rs1808523461,2
    C--63863892(+) GAGACA/GTTGGG 1 -- ut310--------
    rs1384438961,2
    C--63863997(+) ATGTTA/GTTCCA 1 -- ut310--------
    rs120719191,2
    C--63864017(+) ACACAA/GCTTTG 1 -- ut31 ese30--------
    rs1861031741,2
    --63864388(+) TTTTTA/TAAAAA 1 -- ds50010--------
    rs357149331,2
    ----63864046(+) CCCAG-/TCCTAG 1 -- ds50010--------
    rs3772535141,2
    ----63864172(+) ATTCAC/TATTTG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for FOXD3 (63788730 - 63790797 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FOXD3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv461672CNV Gain19166990
    nsv470714CNV Gain18288195


    Human Gene Mutation Database (HGMD): FOXD3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FOXD3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611539   
    OMIM disorders: 607836  
    UniProtKB/Swiss-Prot: FOXD3_HUMAN, Q9UJU5
  • Autoimmune disease 1 (AIS1) [MIM:607836]: An autoimmune disorder characterized by the association of
    vitiligo with autoimmune thyroiditis (Hashimoto thyroiditis). Note=Disease susceptibility is associated with
    variations affecting the gene represented in this entry

  • 14 diseases for FOXD3:    About MalaCards
    senile entropion    autoimmune disease 1    trichomoniasis    entropion
    vestibular nystagmus    chronic myeloid leukemia    vitiligo    teratocarcinoma
    autoimmune thyroiditis    myeloid leukemia    t-cell leukemia    leukemia
    melanoma    thyroiditis

    2 diseases from the University of Copenhagen DISEASES database for FOXD3:
    Entropion     Vestibular nystagmus

    FOXD3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FOXD3
    Human Genome Epidemiology (HuGE) Navigator: FOXD3 (2 documents)

    Export disorders for FOXD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FOXD3 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with FOXD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells. (PubMed id 8499623)1, 2, 3 Hromas R.... Klemsz M. (1993)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. Candidate functional promoter variant in the FOXD3 melanoblast developmental regulator gene in autosomal dominant vitiligo. (PubMed id 16098053)1, 2 Alkhateeb A.... Spritz R.A. (2005)
    4. The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression. (PubMed id 11891324)1, 2 Guo Y.... Hromas R. (2002)
    5. Helicobacter pylori causes epigenetic dysregulation of FOXD3 to promote gastric carcinogenesis. (PubMed id 23058321)1 Cheng A.S....Chan F.K. (2013)
    6. Melanoma adapts to RAF/MEK inhibitors through FOXD3-me diated upregulation of ERBB3. (PubMed id 23543055)1 Abel E.V....Aplin A.E. (2013)
    7. Modulation of FOXD3 activity in human embryonic stem c ells directs pluripotency and paraxial mesoderm fates. (PubMed id 22887036)1 Arduini B.L. and Brivanlou A.H. (2012)
    8. Analysis of FOXD3 sequence variation in human ocular d isease. (PubMed id 22815627)1 Kloss B.A....Semina E.V. (2012)
    9. FOXD3 regulates migration properties and Rnd3 express ion in melanoma cells. (PubMed id 21478267)1 Katiyar P. and Aplin A.E. (2011)
    10. FOXD3 is a mutant B-RAF-regulated inhibitor of G(1)-S progression in melanoma cells. (PubMed id 20332228)1 Abel E.V. and Aplin A.E. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27022 HGNC: 3804 AceView: FOXD3 Ensembl:ENSG00000187140 euGenes: HUgn27022
    ECgene: FOXD3 H-InvDB: FOXD3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FOXD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FOXD3 gene:
    Search GeneIP for patents involving FOXD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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