Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FOXD2 Gene

protein-coding   GIFtS: 46
GCID: GC01P047901

forkhead box D2


(Previous symbol: FKHL17)
 Explore 2 diseases affiliated with
FOXD2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FOXD2    

Aliases
for FOXD2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Forkhead Box D21 2     FREAC-92 3
FKHL171 2 3 5     Forkhead Box Protein D22
FREAC91 2 3 5     Forkhead, Drosophila, Homolog-Like 172
Forkhead-Related Protein FKHL172 3     Forkhead-Like 172
Forkhead-Related Transcription Factor 92 3     Forkhead-Related Activator 92

External Ids:    HGNC: 38031   Entrez Gene: 23062   Ensembl: ENSG000001865647   OMIM: 6022115   UniProtKB: O605483   

Export aliases for FOXD2 gene to outside databases

Previous GC identifers: GC01P047527 GC01P046790 GC01P047260 GC01P047271 GC01P047613 GC01P047674 GC01P046020


Summaries
for FOXD2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FOXD2:
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain.
The specific function of this gene has not yet been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FOXD2_HUMAN, O60548
Function: Probable transcription factor involved in embryogenesis and somatogenesis (By similarity)




Genomic Views
for FOXD2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FOXD2 gene promoter:
         RP58   RREB-1   Egr-1   AP-4   Nkx2-5   GATA-2   C/EBPalpha   Egr-4   CREB   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FOXD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FOXD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34-p32   Ensembl cytogenetic band:  1p33   HGNC cytogenetic band: 1p34-p32

FOXD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXD2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P047901:  view genomic region     (about GC identifiers)

Start:
 47,901,689 bp from pter      End:
 47,906,363 bp from pter
Size:
 4,675 bases      Orientation:
 plus strand

Proteins
for FOXD2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FOXD2_HUMAN, O60548 (See protein sequence)
Recommended Name: Forkhead box protein D2  
Size: 495 amino acids; 48748 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q5SVZ3

Explore the universe of human proteins at neXtProt for FOXD2: NX_O60548

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60548

    • FOXD2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004465.3  
    ENSEMBL proteins: 
     ENSP00000335493  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: FOXD2
    OriGene Custom Protein Services for FOXD2 
    GenScript Custom Purified and Recombinant Proteins Services for FOXD2
    Novus Biologicals FOXD2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FOXD2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005667transcription factor complex IBA--


    FOXD2 for ontologies           About GeneDecksing



    FOXD2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FOXD2 
    GenScript Custom Superior Antibodies Services for FOXD2
    Search for Antibodies for FOXD2 at Abcam  
    Uscn Antibodies for FOXD2
    Search ThermoFisher Antibodies for FOXD2

    Assay Products for FOXD2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FOXD2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for FOXD2

    Protein Domains /
    Families
    for FOXD2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FOXD2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry O60548

    ProtoNet protein and cluster: O60548

    UniProtKB/Swiss-Prot: FOXD2_HUMAN, O60548
    Similarity: Contains 1 fork-head DNA-binding domain


    Function
    for FOXD2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FOXD2_HUMAN, O60548
    Function: Probable transcription factor involved in embryogenesis and somatogenesis (By similarity)

         Genatlas biochemistry entry for FOXD2:
    transcription factor-like 17,with a Drosophila homeo forkhead DNA binding domain homolog,kidney expressed

    miRNA
    Products:            		 OriGene 3'-UTR Clone: FOXD2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOXD2
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXD2 (see all 29):
    hsa-miR-4317 hsa-miR-125a-5p hsa-miR-4272 hsa-miR-1224-3p hsa-let-7a-2* hsa-miR-3138 hsa-miR-374a hsa-miR-766
    SwitchGear 3'UTR luciferase reporter plasmid: FOXD2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOXD2 (see all 4)
    OriGene shRNA RFP: FOXD2
    OriGene siRNA: FOXD2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXD2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for FOXD2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXD2 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXD2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: FOXD2 (NM_004474)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXD2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FOXD2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for FOXD2
    Search LifeMap BioReagents cell lines for FOXD2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXD2

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003690double-stranded DNA binding IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9403061
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IBA--
    GO:0008134transcription factor binding IBA--
    GO:0008301DNA binding, bending IBA--


    FOXD2 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Foxd2):
     renal/urinary system 

    FOXD2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FOXD2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOXD2

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001755neural crest cell migration IBA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007389pattern specification process IBA--
    GO:0007422peripheral nervous system development IBA--
    GO:0009790embryo development IBA--


    FOXD2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FOXD2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FOXD2
    Search CenterWatch for drugs/clinical trials and news about FOXD2 

    Transcripts
    for FOXD2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FOXD2 gene: 
    NM_004474.3  

    Unigene Cluster for FOXD2:

    Forkhead box D2
    Hs.166188  [show with all ESTs]
    Unigene Representative Sequence: NM_004474
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000334793(uc001crm.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: FOXD2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOXD2
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXD2 (see all 29):
    hsa-miR-4317 hsa-miR-125a-5p hsa-miR-4272 hsa-miR-1224-3p hsa-let-7a-2* hsa-miR-3138 hsa-miR-374a hsa-miR-766
    SwitchGear 3'UTR luciferase reporter plasmid: FOXD2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOXD2 (see all 4)
    OriGene shRNA RFP: FOXD2
    OriGene siRNA: FOXD2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXD2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXD2 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXD2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: FOXD2 (NM_004474)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXD2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FOXD2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOXD2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FOXD2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXD2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXD2

    Additional cDNA sequence: AF042832.1 

    1 DOTS entry:

    DT.92071922 

    8 AceView cDNA sequences:

    AF042832 CA432827 NM_004474 BM695703 AW263639 AW009931 BM976063 BX391902 

    GeneLoc Exon Structure


    Expression
    for FOXD2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FOXD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGACTGCTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FOXD2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeBranchial Arch 1Cranial Neural Crest CellsNeural Crest
    Head MesenchymeBranchial Arch 2Cranial Neural Crest CellsNeural Crest
    Head MesenchymePrechordal MesenchymeDiencephalic Neural Crest CellsNeural Crest
    Head MesenchymePrechordal MesenchymeMesencephalic Neural Crest CellsNeural Crest
    KidneyMetanephric MesenchymeMetanephric Mesenchyme CellsKidney
    BoneMandibular ProcessBone
    KidneyMetanephrosKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Beating cell clusters (Spontaneous differen...)

    See FOXD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FOXD2

    SOURCE GeneReport for Unigene cluster: Hs.166188

    UniProtKB/Swiss-Prot: FOXD2_HUMAN, O60548
    Tissue specificity: Kidney specific

        SABiosciences Custom PCR Arrays for FOXD2
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOXD2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FOXD2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXD2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXD2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXD2

    Orthologs
    for FOXD2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FOXD2 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia FOXD26
    		 --
    		 55(a)
    		 1 ↔ 1
    		 GL343249.1(1552955-1554118)
    African clawed frog
    (Xenopus laevis)    		 Amphibia AJ344435.12   -- 83.89(n)    AJ344435.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii foxd11 forkhead box D1 58.08(n)
    58.36(a)    		   30525  NM_131271.2  NP_571346.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta fd59A3 embryonic morphogenesis transcription factor 84(a)   59B4   --
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-1303 fork head domain protein 77(a)   II(11281899-11283574)   --


    ENSEMBL Gene Tree for FOXD2 (if available)
    TreeFam Gene Tree for FOXD2 (if available) 

    Paralogs
    for FOXD2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FOXD2 gene
    FOXF12  FOXA22  FOXD4L12  FOXF22  FOXC22  FOXB12  FOXI22  FOXE32  
    FOXC12  FOXD4L22  FOXQ12  FOXD4L32  FOXA32  FOXD12  FOXD32  FOXD4L52  
    FOXD4L42  FOXE12  FOXL12  FOXA12  FOXI12  FOXB22  FOXD4L62  FOXS12  
    FOXL22  FOXD42  
    10 SIMAP similar genes for FOXD2 using alignment to 1 protein entry:     FOXD2_HUMAN:
    FOXD4L3    FOXD4L6    FOXA3    FOXD4L2    FOXD4L4    FOXD4L5
    FOXE3    FOXD1    FOXE1    FOXD4

    FOXD2 for paralogs           About GeneDecksing



    Genomic Variants
    for FOXD2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/95 NCBI SNPs in FOXD2 are shown (see all 95)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs28209781,2
    		H--47899725(+) ATCTGC/TGGGCG 2 -- nc-transcript-variantus2k14Minor allele frequency- T:0.00NS EA 418
    rs1158187361,2
    		F,--47899813(+) GCAATC/GGTTCC 2 -- nc-transcript-variantus2k11Minor allele frequency- G:0.03WA 118
    rs38140051,2
    		C,F,H,--47899897(+) CCGCAT/CAATCG 2 -- us2k1 nc-transcript-variant19Minor allele frequency- C:0.18EA NS NA WA 3822
    rs1923065331,2
    		--47900006(+) CTCTTC/TGCAAA 2 -- us2k1 nc-transcript-variant0--------
    rs1147270881,2
    		F,--47900058(+) CTCCGC/TCCGCC 2 -- nc-transcript-variantus2k11Minor allele frequency- T:0.03WA 118
    rs1421002041,2
    		--47900191(+) CCGCTC/TTTTGG 2 -- nc-transcript-variantus2k10--------
    rs1511999471,2
    		--47900320(+) TGAGCA/CGGTAG 2 -- us2k10--------
    rs1391214581,2
    		--47900380(+) CGAATA/CCCGCG 2 -- us2k10--------
    rs120359951,2
    		C,F,H,--47900459(+) TGGAAG/AGGAGG 2 -- us2k1 trp319Minor allele frequency- A:0.18NS EA NA WA CSA 2343
    rs65883901,2
    		C,H,--47900463(+) AGGGAT/GGAGAG 2 -- us2k1 trp312Minor allele frequency- G:0.01NA WA CSA 141

    HapMap Linkage Disequilibrium report for FOXD2 (47901689 - 47906363 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FOXD2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOXD2
    DNA2.0 Custom Variant and Variant Library Synthesis for FOXD2

    Disorders / Diseases
    for FOXD2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FOXD2 for disorders           About GeneDecksing

    OMIM gene information: 602211    OMIM disorders: --

    2 diseases for FOXD2:    About MalaCards
    croup    neuronitis

    1 disease from the University of Copenhagen DISEASES database for FOXD2:
    Croup

    Export disorders for FOXD2 gene to outside databases

    Publications
    for FOXD2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FOXD2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FOXD2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of freac-9 (FKHL17), a novel kidney- expressed human forkhead gene that maps to chromosome 1p32-p34. (PubMed id 9403061)1, 2, 3, 9 Ernstsson S.... Enerbaeck S. (1997)
    2. A winged helix forkhead (FOXD2) tunes sensitivity to cAMP in T lymphocytes through regulation of cAMP-dependent protein kinase RIalpha. (PubMed id 12621056)1, 3 Johansson C.C....Tasken K. (2003)
    3. Identification of Rhit as a novel transcriptional repressor of human Mpv17-like protein with a mitigating effect on mitochondrial dysf unction, and its transcriptional regulation by FOXD3 and GABP. (PubMed id 22306510)1 Iida R....Yasuda T. (2012)
    4. Pharmacogenomic study of side-effects for antidepressa nt treatment options in STAR*D. (PubMed id 22041458)1 Clark S.L....van den Oord E.J. (2012)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    6. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    External Searches for FOXD2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FOXD2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2306 HGNC: 3803 AceView: FOXD2 Ensembl:ENSG00000186564 euGenes: HUgn2306
    ECgene: FOXD2 H-InvDB: FOXD2

    Other Databases showing FOXD2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FOXD2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FOXD2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FOXD2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for FOXD2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FOXD2 gene:
    Search GeneIP for patents involving FOXD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for FOXD2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for FOXD2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOXD2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOXD2  
     OriGene Protein Over-expression Lysate for FOXD2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for FOXD2   OriGene 3'-UTR Clone for FOXD2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXD2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXD2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FOXD2   OriGene Custom Protein Services for FOXD2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FOXD2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOXD2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXD2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXD2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXD2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXD2
     GenScript Custom Purified and Recombinant Proteins Services for FOXD2 GenScript cDNA clones with any tag delivered in your preferred vector for FOXD2
     GenScript Custom Assay Services for FOXD2 GenScript Custom Superior Antibodies Services for FOXD2
     GenScript Custom overexpressing Cell Line Services for FOXD2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FOXD2 promoter
     Search Chromatin IP Primers for FOXD2
     RT2 qPCR Primer Assay in human, mouse, rat FOXD2
     Search GNC Networks for FOXD2
     SABiosciences Custom PCR Arrays for FOXD2
     Search Tocris compounds for FOXD2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FOXD2 proteins
     Search for Antibodies for FOXD2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for FOXD2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     FOXD2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for FOXD2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXD2
     SwitchGear 3'UTR luciferase reporter plasmids for FOXD2
     SwitchGear Promoter luciferase reporter plasmids for FOXD2
     Search ThermoFisher Antibodies for FOXD2
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FOXD2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      FOXD2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4