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Aliases for FOXD2 Gene

Aliases for FOXD2 Gene

  • Forkhead Box D2 2 3 5
  • Forkhead-Related Transcription Factor 9 3 4
  • Forkhead-Related Protein FKHL17 3 4
  • FREAC-9 3 4
  • FKHL17 3 4
  • FREAC9 3 4
  • Forkhead, Drosophila, Homolog-Like 17 3
  • Forkhead-Related Activator 9 3
  • Forkhead Box Protein D2 3
  • Forkhead-Like 17 3

External Ids for FOXD2 Gene

Previous HGNC Symbols for FOXD2 Gene

  • FKHL17

Previous GeneCards Identifiers for FOXD2 Gene

  • GC01P047527
  • GC01P046790
  • GC01P047260
  • GC01P047271
  • GC01P047613
  • GC01P047674
  • GC01P047901
  • GC01P046020

Summaries for FOXD2 Gene

Entrez Gene Summary for FOXD2 Gene

  • This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXD2 Gene

FOXD2 (Forkhead Box D2) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXD1.

UniProtKB/Swiss-Prot for FOXD2 Gene

  • Probable transcription factor involved in embryogenesis and somatogenesis.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXD2 Gene

Genomics for FOXD2 Gene

Regulatory Elements for FOXD2 Gene

Enhancers for FOXD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G047188 1.5 Ensembl ENCODE dbSUPER 10 -244.8 -244783 4.5 HDGF PKNOX1 ATF1 MLX ARID4B DMAP1 ZNF2 ZNF48 TCF12 GATA2 PDZK1IP1 ENSG00000226252 TAL1 FOXE3 LINC01389 FOXD2 FOXD2-AS1 GC01M047220
GH01G047758 1.4 FANTOM5 ENCODE dbSUPER 9.5 +323.2 323181 1.6 TBP RAD21 BRCA1 RFX5 RCOR1 EGR2 SMARCC1 NFYA USF2 CEBPB FOXD2 FOXD2-AS1 LOC105378702 ENSG00000223814 GC01M047709
GH01G047695 1.1 ENCODE dbSUPER 11.4 +262.2 262235 4.6 PKNOX1 THRB ZBTB40 RAD21 RARA YY1 CEBPB NR2F2 ZNF341 GLIS1 FOXD2 FOXD2-AS1 LINC01389 FOXE3 LINC01738 PIR52707 GC01P047709
GH01G047477 1 ENCODE 11.4 +41.9 41945 1.5 PKNOX1 FOXA2 MLX ARID4B ZNF48 YY1 SLC30A9 SP5 ZHX2 MXD4 FOXD2 FOXD2-AS1 LINC01389 FOXE3 CYP4A22-AS1 LINC00853 ENSG00000271355 GC01M047436
GH01G047332 1.7 FANTOM5 ENCODE dbSUPER 4.6 -101.7 -101729 4.2 HDGF FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 ENSG00000226252 FOXE3 CMPK1 TAL1 LINC01389 PDZK1IP1 FOXD2 GC01P047350
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FOXD2 on UCSC Golden Path with GeneCards custom track

Promoters for FOXD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000006055 1583 2001 HDGF ARNT ARID4B SIN3A ZNF2 CBX5 ZNF143 DEK ZNF263 SP3

Genomic Location for FOXD2 Gene

47,436,017 bp from pter
47,440,691 bp from pter
4,675 bases
Plus strand

Genomic View for FOXD2 Gene

Genes around FOXD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXD2 Gene

Proteins for FOXD2 Gene

  • Protein details for FOXD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Forkhead box protein D2
    Protein Accession:
    Secondary Accessions:
    • Q5SVZ3

    Protein attributes for FOXD2 Gene

    495 amino acids
    Molecular mass:
    48748 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXD2 Gene

Post-translational modifications for FOXD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXD2 Gene

Domains & Families for FOXD2 Gene

Gene Families for FOXD2 Gene

Protein Domains for FOXD2 Gene

Suggested Antigen Peptide Sequences for FOXD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FOXD2: view

No data available for UniProtKB/Swiss-Prot for FOXD2 Gene

Function for FOXD2 Gene

Molecular function for FOXD2 Gene

GENATLAS Biochemistry:
transcription factor-like 17,with a Drosophila homeo forkhead DNA binding domain homolog,kidney expressed
UniProtKB/Swiss-Prot Function:
Probable transcription factor involved in embryogenesis and somatogenesis.

Gene Ontology (GO) - Molecular Function for FOXD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 9403061
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXD2: view
genes like me logo Genes that share phenotypes with FOXD2: view

Animal Models for FOXD2 Gene

MGI Knock Outs for FOXD2:

Animal Model Products

CRISPR Products

miRNA for FOXD2 Gene

miRTarBase miRNAs that target FOXD2

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOXD2 Gene

Localization for FOXD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXD2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXD2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for FOXD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IEA --
genes like me logo Genes that share ontologies with FOXD2: view

Pathways & Interactions for FOXD2 Gene

SuperPathways for FOXD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with FOXD2: view

No data available for Pathways by source and SIGNOR curated interactions for FOXD2 Gene

Drugs & Compounds for FOXD2 Gene

No Compound Related Data Available

Transcripts for FOXD2 Gene

mRNA/cDNA for FOXD2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXD2 Gene

Forkhead box D2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXD2 Gene

No ASD Table

Relevant External Links for FOXD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FOXD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOXD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXD2 Gene

This gene is overexpressed in Colon - Transverse (x9.9), Nerve - Tibial (x8.8), and Artery - Aorta (x5.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FOXD2 Gene

Protein tissue co-expression partners for FOXD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FOXD2 Gene:


SOURCE GeneReport for Unigene cluster for FOXD2 Gene:


mRNA Expression by UniProt/SwissProt for FOXD2 Gene:

Tissue specificity: Kidney specific.
genes like me logo Genes that share expression patterns with FOXD2: view

Primer Products

No data available for Protein differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXD2 Gene

Orthologs for FOXD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FOXD2 34
  • 96.62 (n)
(Bos Taurus)
Mammalia FOXD2 34 35
  • 89.72 (n)
(Mus musculus)
Mammalia Foxd2 34 16 35
  • 82.99 (n)
(Rattus norvegicus)
Mammalia Foxd2 34
  • 82.24 (n)
(Monodelphis domestica)
Mammalia FOXD2 35
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia FOXD2 35
  • 64 (a)
(Gallus gallus)
Aves FOXD1 35
  • 83 (a)
(Anolis carolinensis)
Reptilia FOXD2 35
  • 57 (a)
(Danio rerio)
Actinopterygii foxd1 35
  • 51 (a)
fruit fly
(Drosophila melanogaster)
Insecta fd59A 36 35
  • 84 (a)
(Caenorhabditis elegans)
Secernentea unc-130 36 35
  • 77 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
CSA.2032 35
  • 28 (a)
Species where no ortholog for FOXD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FOXD2 Gene

Gene Tree for FOXD2 (if available)
Gene Tree for FOXD2 (if available)

Paralogs for FOXD2 Gene

(9) SIMAP similar genes for FOXD2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXD2: view

Variants for FOXD2 Gene

Sequence variations from dbSNP and Humsavar for FOXD2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000176777 -- 47,434,464(+) GAGGC(A/C)CGGCA intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000589236 -- 47,440,217(+) CAGGG(G/T)GTCTT utr-variant-3-prime
rs1001340469 -- 47,435,611(+) AAGGT(A/G)AAATG intron-variant, upstream-variant-2KB
rs1001482835 -- 47,439,989(+) CCAAC(A/G)GAGGG utr-variant-3-prime
rs1001538155 -- 47,435,373(+) AGAAA(-/CCT)CCTCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FOXD2 Gene

Variant ID Type Subtype PubMed ID
nsv1001779 CNV gain 25217958
nsv950710 CNV deletion 24416366

Variation tolerance for FOXD2 Gene

Gene Damage Index Score: 5.22; 69.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXD2 Gene

Disorders for FOXD2 Gene

Relevant External Links for FOXD2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FOXD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXD2 Gene

Publications for FOXD2 Gene

  1. Cloning and characterization of freac-9 (FKHL17), a novel kidney- expressed human forkhead gene that maps to chromosome 1p32-p34. (PMID: 9403061) Ernstsson S. … Enerbaeck S. (Genomics 1997) 2 3 4 22 64
  2. Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D. (PMID: 22041458) Clark S.L. … van den Oord E.J. (Psychol Med 2012) 3 46 64
  3. A winged helix forkhead (FOXD2) tunes sensitivity to cAMP in T lymphocytes through regulation of cAMP-dependent protein kinase RIalpha. (PMID: 12621056) Johansson C.C. … TaskAcn K. (J. Biol. Chem. 2003) 2 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for FOXD2 Gene

Sources for FOXD2 Gene

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