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Aliases for FOXD2 Gene

Aliases for FOXD2 Gene

  • Forkhead Box D2 2 3
  • FKHL17 3 4 6
  • FREAC9 3 4 6
  • Forkhead-Related Transcription Factor 9 3 4
  • Forkhead-Related Protein FKHL17 3 4
  • FREAC-9 3 4
  • Forkhead, Drosophila, Homolog-Like 17 3
  • Forkhead-Related Activator 9 3
  • Forkhead Box Protein D2 3
  • Forkhead-Like 17 3

External Ids for FOXD2 Gene

Previous Symbols for FOXD2 Gene

  • FKHL17

Summaries for FOXD2 Gene

Entrez Gene Summary for FOXD2 Gene

  • This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXD2 Gene

FOXD2 (Forkhead Box D2) is a Protein Coding gene. Diseases associated with FOXD2 include croup. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is FOXE3.

UniProtKB/Swiss-Prot for FOXD2 Gene

  • Probable transcription factor involved in embryogenesis and somatogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXD2 Gene

Genomics for FOXD2 Gene

Genomic Location for FOXD2 Gene

47,436,017 bp from pter
47,440,691 bp from pter
4,675 bases
Plus strand

Genomic View for FOXD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXD2 Gene

Regulatory Elements for FOXD2 Gene

Proteins for FOXD2 Gene

  • Protein details for FOXD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Forkhead box protein D2
    Protein Accession:
    Secondary Accessions:
    • Q5SVZ3

    Protein attributes for FOXD2 Gene

    495 amino acids
    Molecular mass:
    48748 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXD2 Gene

Proteomics data for FOXD2 Gene at MOPED

Post-translational modifications for FOXD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXD2 Gene

Domains for FOXD2 Gene

Gene Families for FOXD2 Gene

  • FOX :Forkhead boxes

Protein Domains for FOXD2 Gene


  • Contains 1 fork-head DNA-binding domain.:
    • O60548
genes like me logo Genes that share domains with FOXD2: view

Function for FOXD2 Gene

Molecular function for FOXD2 Gene

GENATLAS Biochemistry: transcription factor-like 17,with a Drosophila homeo forkhead DNA binding domain homolog,kidney expressed
UniProtKB/Swiss-Prot Function: Probable transcription factor involved in embryogenesis and somatogenesis.

Gene Ontology (GO) - Molecular Function for FOXD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 9403061
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXD2: view

Phenotypes for FOXD2 Gene

MGI mutant phenotypes for FOXD2:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with FOXD2: view

miRNA for FOXD2 Gene

miRTarBase miRNAs that target FOXD2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FOXD2 Gene

Localization for FOXD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXD2 Gene

Subcellular locations from

Jensen Localization Image for FOXD2 Gene COMPARTMENTS Subcellular localization image for FOXD2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for FOXD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with FOXD2: view

Pathways for FOXD2 Gene

SuperPathways for FOXD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0009653 anatomical structure morphogenesis IBA --
genes like me logo Genes that share ontologies with FOXD2: view

No data available for Pathways by source for FOXD2 Gene

Transcripts for FOXD2 Gene

mRNA/cDNA for FOXD2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXD2 Gene

Forkhead box D2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXD2 Gene

No ASD Table

Relevant External Links for FOXD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FOXD2 Gene

mRNA expression in normal human tissues for FOXD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXD2 Gene

This gene is overexpressed in Colon - Transverse (9.9), Nerve - Tibial (8.8), and Artery - Aorta (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FOXD2 Gene

SOURCE GeneReport for Unigene cluster for FOXD2 Gene Hs.166188

mRNA Expression by UniProt/SwissProt for FOXD2 Gene

Tissue specificity: Kidney specific.
genes like me logo Genes that share expressions with FOXD2: view

Orthologs for FOXD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FOXD2 36
  • 96.62 (n)
  • 95.33 (a)
(Bos Taurus)
Mammalia FOXD2 36
  • 89.72 (n)
  • 90.87 (a)
FOXD2 37
  • 90 (a)
(Mus musculus)
Mammalia Foxd2 36
  • 82.99 (n)
  • 85.31 (a)
Foxd2 16
Foxd2 37
  • 94 (a)
(Monodelphis domestica)
Mammalia FOXD2 37
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia FOXD2 37
  • 64 (a)
(Rattus norvegicus)
Mammalia Foxd2 36
  • 82.24 (n)
  • 83.67 (a)
(Gallus gallus)
Aves FOXD1 37
  • 83 (a)
(Anolis carolinensis)
Reptilia FOXD2 37
  • 57 (a)
(Danio rerio)
Actinopterygii foxd1 37
  • 51 (a)
fruit fly
(Drosophila melanogaster)
Insecta fd59A 37
  • 28 (a)
fd59A 38
  • 84 (a)
(Caenorhabditis elegans)
Secernentea unc-130 37
  • 34 (a)
unc-130 38
  • 77 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 28 (a)
CSA.2032 37
  • 28 (a)
Species with no ortholog for FOXD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FOXD2 Gene

Gene Tree for FOXD2 (if available)
Gene Tree for FOXD2 (if available)

Paralogs for FOXD2 Gene

Selected SIMAP similar genes for FOXD2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXD2: view

Variants for FOXD2 Gene

Sequence variations from dbSNP and Humsavar for FOXD2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2279277 -- 47,440,948(-) CTCCA(C/G)GCAAC downstream-variant-500B
rs2405913 - 47,439,237(-) CGCCG(C/G)GTAGA missense, reference
rs2622916 -- 47,440,753(-) AAGCT(C/T)TTCTG downstream-variant-500B
rs2820966 -- 47,440,666(+) GTGTC(A/G/T)ATTGA utr-variant-3-prime
rs3046924 -- 47,438,996(-) tgcgg(-/GTGCGG)atgcg cds-indel

Structural Variations from Database of Genomic Variants (DGV) for FOXD2 Gene

Variant ID Type Subtype PubMed ID
nsv871961 CNV Loss 21882294
nsv871299 CNV Gain 21882294

Relevant External Links for FOXD2 Gene

HapMap Linkage Disequilibrium report

Disorders for FOXD2 Gene

(1) MalaCards Diseases for FOXD2 Gene

Search for FOXD2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for FOXD2 Gene

Relevant External Links for FOXD2

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with FOXD2: view

No data available for UniProtKB/Swiss-Prot for FOXD2 Gene

Publications for FOXD2 Gene

  1. Cloning and characterization of freac-9 (FKHL17), a novel kidney- expressed human forkhead gene that maps to chromosome 1p32-p34. (PMID: 9403061) Ernstsson S. … Enerbaeck S. (Genomics 1997) 2 3 4 23
  2. A winged helix forkhead (FOXD2) tunes sensitivity to cAMP in T lymphocytes through regulation of cAMP-dependent protein kinase RIalpha. (PMID: 12621056) Johansson C.C. … TaskAcn K. (J. Biol. Chem. 2003) 2 3
  3. Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D. (PMID: 22041458) Clark S.L. … van den Oord E.J. (Psychol Med 2012) 3 49
  4. Identification of Rhit as a novel transcriptional repressor of human Mpv17-like protein with a mitigating effect on mitochondrial dysfunction, and its transcriptional regulation by FOXD3 and GABP. (PMID: 22306510) Iida R. … Yasuda T. (Free Radic. Biol. Med. 2012) 3
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3

Products for FOXD2 Gene

Sources for FOXD2 Gene

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