Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FOXC2 Gene

protein-coding   GIFtS: 60
GCID: GC16P086600

Forkhead Box C2 (MFH-1, Mesenchyme Forkhead 1)


(Previous symbol: FKHL14)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Forkhead Box C2 (MFH-1, Mesenchyme Forkhead 1)1 2     LD2
FKHL141 2 3 5     MFH-12
MFH12 3 5     Forkhead Box Protein C22
Forkhead-Related Protein FKHL142 3     Forkhead, Drosophila, Homolog-Like 142
Mesenchyme Fork Head Protein 12 3     MFH-1,Mesenchyme Forkhead 12
Transcription Factor FKH-142 3     MFH-1 Protein3

External Ids:    HGNC: 38011   Entrez Gene: 23032   Ensembl: ENSG000001766927   OMIM: 6024025   UniProtKB: Q999583   

Export aliases for FOXC2 gene to outside databases

Previous GC identifers: GC16P077956 GC16P087633 GC16P086341 GC16P086382 GC16P085158 GC16P072340


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FOXC2 Gene:
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding
forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in
the development of mesenchymal tissues. (provided by RefSeq, Jul 2008)

GeneCards Summary for FOXC2 Gene: 
FOXC2 (forkhead box C2 (MFH-1, mesenchyme forkhead 1)) is a protein-coding gene. Diseases associated with FOXC2 include lymphedema-distichiasis syndrome, and arachnoid cysts. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOXF1.

UniProtKB/Swiss-Prot: FOXC2_HUMAN, Q99958
Function: Transcriptional activator. Might be involved in the formation of special mesenchymal tissues

Gene Wiki entry for FOXC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FOXC2 gene promoter:
         MyoD   Pax-4a   C/EBPalpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FOXC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.1   Ensembl cytogenetic band:  16q24.1   HGNC cytogenetic band: 16q24.1

FOXC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXC2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P086600:  view genomic region     (about GC identifiers)

Start:
86,600,857 bp from pter      End:
86,602,539 bp from pter
Size:
1,683 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FOXC2_HUMAN, Q99958 (See protein sequence)
Recommended Name: Forkhead box protein C2  
Size: 501 amino acids; 53719 Da
Subcellular location: Nucleus (Probable)
1 PDB 3D structure from and Proteopedia for FOXC2:
1D5V (3D)    
Secondary accessions: C6KMR9 Q14DA6

Explore the universe of human proteins at neXtProt for FOXC2: NX_Q99958

Explore proteomics data for FOXC2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99958

  • FOXC2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FOXC2 Protein Expression
    REFSEQ proteins: NP_005242.1  
    ENSEMBL proteins: 
     ENSP00000326371  

    Human Recombinant Protein Products for FOXC2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for FOXC2
    OriGene Protein Over-expression Lysate for FOXC2
    OriGene MassSpec for FOXC2 
    OriGene Custom Protein Services for FOXC2
    GenScript Custom Purified and Recombinant Proteins Services for FOXC2
    Novus Biologicals FOXC2 Proteins
    Novus Biologicals FOXC2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FOXC2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11562355
    GO:0005667transcription factor complex IBA--

    FOXC2 for ontologies           About GeneDecksing



    FOXC2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for FOXC2
    OriGene Antibodies for FOXC2
    OriGene Custom Antibody Services for FOXC2
    GenScript Custom Superior Antibodies Services for FOXC2
    Novus Biologicals FOXC2 Antibodies
    Abcam antibodies for FOXC2
    Cloud-Clone Corp. Antibodies for FOXC2 
    ThermoFisher Antibody for FOXC2
    LSBio Antibodies in human, mouse, rat for FOXC2 

    Assay Products for FOXC2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FOXC2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FOXC2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FOXC2 
    Cloud-Clone Corp. CLIAs for FOXC2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FOX: Forkhead boxes

    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry Q99958

    ProtoNet protein and cluster: Q99958

    UniProtKB/Swiss-Prot: FOXC2_HUMAN, Q99958
    Similarity: Contains 1 fork-head DNA-binding domain


    FOXC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOXC2_HUMAN, Q99958
    Function: Transcriptional activator. Might be involved in the formation of special mesenchymal tissues

         Genatlas biochemistry entry for FOXC2:
    transcription factor-like 14,with a Drosophila homeo forkhead DNA binding domain homolog,homolog to mouse
    mesenchyme forkhead 1 (MFH-1)

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA--
    GO:0003677DNA binding ----
    GO:0003690double-stranded DNA binding IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity IDA9169153
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IBA--
         
    FOXC2 for ontologies           About GeneDecksing


    Phenotypes:
         15/20 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Foxc2) (see all 20):
     adipose tissue  cardiovascular system  craniofacial  digestive/alimentary  embryogenesis 
     growth/size  hearing/vestibular/ear  homeostasis/metabolism  immune system  liver/biliary system 
     mortality/aging  muscle  nervous system  no phenotypic analysis  normal 

    FOXC2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FOXC2: Foxc2tm1Miu Foxc2tm1.2Tsku Foxc2tm1Blh

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FOXC2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FOXC2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FOXC2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FOXC2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOXC2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXC2:
    hsa-miR-1184 hsa-miR-593
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FOXC2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXC2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FOXC2
    Sirion Biotech Customized adenovirus for overexpression of FOXC2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for FOXC2 (see all 7)
    OriGene ORF clones in mouse, rat for FOXC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FOXC2 (NM_005251)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXC2
    Sirion Biotech Customized lentivirus for stable overexpression of FOXC2 
                         Customized lentivirus expression plasmids for stable overexpression of FOXC2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FOXC2
    Search LifeMap BioReagents cell lines for FOXC2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXC2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FOXC2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Adipogenesis
    Adipogenesis
    2Heart Development
    Heart Development


    2 BioSystems Pathways for FOXC2
        Heart Development
    Adipogenesis


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FOXC2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for FOXC2 (Q999583 ENSP000003263714) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    KDM5BQ9UGL13, ENSP000003562344I2D: score=1 STRING: ENSP00000356234
    SUMO2ENSP000004059654STRING: ENSP00000405965
    About this table

    Gene Ontology (GO): 5/48 biological process terms (GO ID links to tree view) (see all 48):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0001501skeletal system development ----
    GO:0001503ossification IBA--
    GO:0001568blood vessel development ----
    GO:0001569patterning of blood vessels IBA--

    FOXC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FOXC2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FOXC2

    2 Novoseek inferred chemical compound relationships for FOXC2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 4.06 2 15298355 (1), 12716768 (1)
    lipid 0 1 16786163 (1)

    Search CenterWatch for drugs/clinical trials and news about FOXC2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FOXC2 gene: 
    NM_005251.2  

    Unigene Cluster for FOXC2:

    Forkhead box C2 (MFH-1, mesenchyme forkhead 1)
    Hs.436448  [show with all ESTs]
    Unigene Representative Sequence: NM_005251
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000320354(uc002fjq.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOXC2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXC2:
    hsa-miR-1184 hsa-miR-593
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FOXC2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXC2
    Clone
    Products:
         
    OriGene clones in human, mouse for FOXC2 (see all 7)
    OriGene ORF clones in mouse, rat for FOXC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FOXC2 (NM_005251)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXC2
    Sirion Biotech Customized lentivirus for stable overexpression of FOXC2 
                         Customized lentivirus expression plasmids for stable overexpression of FOXC2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FOXC2
    OriGene qSTAR qPCR primer pairs in human, mouse for FOXC2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FOXC2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXC2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXC2

    Additional mRNA sequence: 

    BC113437.1 BC113439.1 

    4 DOTS entries:

    DT.437963  DT.40299149  DT.100749672  DT.95326906 

    7 AceView cDNA sequences:

    BM728520 AU119542 AU118037 NM_005251 AA373083 CD172158 AA373084 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FOXC2 expression in normal human tissues (normalized intensities)      FOXC2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCGTCCCGC
    FOXC2 Expression
    About this image


    FOXC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/27 selected tissues (see all 27) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 31 entries
             Prechondrocytic Mesenchymal Cells Lumbar Intervertebral Disc
             skeleton/cranium   
     
     Bone (Muscoskeletal System)    fully expand to see all 29 entries
             Prechondrocytic Mesenchymal Cells Cervical Spinous Process Of Vertebrae
             Human Vertebral Mesenchymal Stem Cells (HVMSC)   
             sensory organ/ear/inner ear   
     
     Kidney (Urinary System)    fully expand to see all 8 entries
             Comma-shaped Body Cells Comma-shaped Body
             S-shaped Body
     
     Somite (Muscoskeletal System)    fully expand to see all 8 entries
             Muscle Progenitor Cells Sacral Ventrolateral Dermomyotome Lip
     
     Adipose (Muscoskeletal System)    fully expand to see all 8 entries
             Lumbar Committed Brown Preadipocytes Lumbar Brown Adipose Depot

    See FOXC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FOXC2

    SOURCE GeneReport for Unigene cluster: Hs.436448
        SABiosciences Expression via Pathway-Focused PCR Arrays including FOXC2: 
              Cancer PathwayFinder in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat
              Diabetes in human mouse rat
              Adipogenesis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FOXC2
    OriGene qSTAR qPCR primer pairs in human, mouse for FOXC2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FOXC2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXC2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXC2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FOXC2 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Foxc21 , 5 forkhead box C21, 5 88.53(n)1
    91.09(a)1
      8 (70.33 cM)5
    142341  NM_013519.21  NP_038547.21 
     1211161715 
    chicken
    (Gallus gallus)
    Aves FOXC21 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 77.53(n)
    75.67(a)
      396039  NM_205138.1  NP_990469.1 
    lizard
    (Anolis carolinensis)
    Reptilia FOXC26
    Uncharacterized protein
    56(a)
    1 ↔ 1
    AAWZ02037033(11383-12843)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.5082 Xenopus laevis mRNA for XFD-4' protein (fd-4' gene) 79.89(n)    AJ249225.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fd64A3 embryonic morphogenesis transcription
    factor
    65(a)
    (best of 3)
      64A4   --


    ENSEMBL Gene Tree for FOXC2 (if available)
    TreeFam Gene Tree for FOXC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FOXC2 gene
    FOXF12  FOXA22  FOXF22  FOXD4L12  FOXI22  FOXB12  FOXE32  FOXC12  
    FOXD4L22  FOXD4L32  FOXA32  FOXD4L52  FOXD12  FOXD32  FOXD4L42  FOXL12  
    FOXA12  FOXE12  FOXB22  FOXI12  FOXD4L62  FOXS12  FOXD22  FOXL22  
    FOXD42  
    10 SIMAP similar genes for FOXC2 using alignment to 7 protein entries:     FOXC2_HUMAN (see all proteins):
    FOXJ3    FOXN3    FOXC1    FOXK2    FOXL2    FOXP2
    FOXL1    FOXD4L1    FOXS1    FOXA3

    FOXC2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/124 SNPs in FOXC2 are shown (see all 124)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0184184
    Lymphedema-distichiasis (LYD)4--see VAR_0184182 S L mis40--------
    rs1048945161,2
    Cpathogenic187605310(+) ATCTAC/GCAGTT 2 Y * stg10--------
    rs788697791,2
    C,F--86599099(+) CAAATAAAC/-  
            
    AAACT
    1 -- us2k13Minor allele frequency- -:0.09NS 110
    rs740337241,2
    C,F--87602970(+) CCGATG/AAACAG 1 -- us2k12Minor allele frequency- A:0.03WA 120
    rs1818324761,2
    --87603119(+) GGGAAA/GAGGGG 1 -- us2k10--------
    rs1450320561,2
    --87603253(+) AATAAC/TATCAT 1 -- us2k10--------
    rs1176644381,2
    F--87603312(+) CCACGG/CAGCGC 1 -- us2k11Minor allele frequency- C:0.02NA 120
    rs774790101,2
    C,F--87603342(+) CCACCC/TAACAA 1 -- us2k13Minor allele frequency- T:0.00NS 110
    rs1476056561,2
    C--87603350(+) AAAAC-/AAAAAA 1 -- us2k10--------
    rs48431621,2
    C,F,A--87603476(+) GGGAAA/GCGTCC 1 -- us2k18Minor allele frequency- G:0.12NS WA CSA NA EA 474

    HapMap Linkage Disequilibrium report for FOXC2 (86600857 - 86602539 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for FOXC2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv525024CNV Loss19592680
    nsv907138CNV Loss21882294
    nsv907132CNV Loss21882294
    nsv907137CNV Loss21882294
    dgv2947n71CNV Loss21882294
    dgv498n67CNV Gain20364138
    esv4262CNV Complex18987735


    Human Gene Mutation Database (HGMD): FOXC2
    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing FOXC2:
    Birth Defects
    SeqTarget long-range PCR primers for resequencing FOXC2
    DNA2.0 Custom Variant and Variant Library Synthesis for FOXC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602402   
    OMIM disorders: 153400  
    UniProtKB/Swiss-Prot: FOXC2_HUMAN, Q99958
  • Lymphedema, hereditary, 2 (LMPH2) [MIM:153200]: A chronic disabling condition which results in swelling
    of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local
    infections, and physical impairment. Note=The disease is caused by mutations affecting the gene represented in
    this entry
  • Lymphedema-yellow nails (LYYN) [MIM:153300]: A disorder characterized by yellow, dystrophic, thick and
    slowly growing nails, associated with lymphedema and respiratory involvement. Lymphedema occurs more often in the
    lower limbs. It can appear at birth or later in life. Onset generally follows the onset of ungual abnormalities.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Lymphedema-distichiasis (LYD) [MIM:153400]: A disorder characterized by primary limb lymphedema usually
    starting at puberty (but in some cases later or at birth) and associated with distichiasis (double rows of
    eyelashes, with extra eyelashes growing from the Meibomian gland orifices). Drooping of the upper eyelid (ptosis)
    is a variable feature of the lymphedema-distichiasis syndrome, occurring in about 30% of patients. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 20/29 diseases for FOXC2 (see all 29):    About MalaCards
    lymphedema-distichiasis syndrome    arachnoid cysts    arachnoiditis    lymphedema - cleft palate
    yellow nail syndrome    lymphedema-distichiasis syndrome with renal disease and diabetes mellitus    exotropia    hereditary lymphedema
    varicose veins    intestinal lymphangiectasia    alveolar capillary dysplasia    gestational diabetes
    klippel-trenaunay syndrome    hypoplastic left heart syndrome    lymphedema    cleft palate
    hypertriglyceridemia    hypotrichosis    insulin resistance    hydrops fetalis

    3 diseases from the University of Copenhagen DISEASES database for FOXC2:
    Lymphedema     Meige syndrome     Klippel-Trenaunay syndrome

    FOXC2 for disorders           About GeneDecksing

    10/17 Novoseek inferred disease relationships for FOXC2 gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphedema-distichiasis syndrome 98.7 16 20218083 (2), 11371511 (2), 12719382 (1), 17366583 (1) (see all 13)
    distichiasis 97.2 15 14566319 (2), 16081467 (2), 17372167 (2), 18197197 (2) (see all 10)
    lymphedema primary 92.4 5 19760751 (2), 18986489 (1), 18564920 (1), 17372167 (1)
    congenital lymphedema 90.4 4 16081467 (2), 19093784 (1), 18519967 (1)
    lymphedema 87.6 22 11371511 (3), 17372167 (3), 18197197 (3), 12485195 (2) (see all 12)
    klippel-trenaunay syndrome 56.1 1 16379592 (1)
    cleft palate 45.2 1 12485195 (1)
    vascular anomaly 40.8 1 15905966 (1)
    congenital malformation 36 1 12543715 (1)
    hypertriglyceridemia 33.1 3 11551504 (2), 12716768 (1)

    GeneTests: FOXC2
    GeneReviews: FOXC2
    Genetic Association Database (GAD): FOXC2
    Human Genome Epidemiology (HuGE) Navigator: FOXC2 (23 documents)

    Export disorders for FOXC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FOXC2 gene, integrated from 9 sources (see all 122):
    (articles sorted by number of sources associating them with FOXC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of the mouse (MFH-1) and human (FKHL 14) mesenchyme fork head-1 genes reveals conservation of their gene and protein structures. (PubMed id 9169153)1, 2, 3, 9 Miura N.... Sugiyama T. (1997)
    2. FOXC2 mRNA Expression and a 5' untranslated region polymorphism of the gene are associated with insulin resistance. (PubMed id 12453913)1, 4, 9 Ridderstrale M....Groop L. (2002)
    3. Association of polymorphisms in forkhead box C2 and perilipin genes with bone mineral density in community-dwelling Japanese individuals. (PubMed id 16786163)1, 4, 9 Yamada Y....Shimokata H. (2006)
    4. Truncating mutations in FOXC2 cause multiple lymphedema syndromes. (PubMed id 11371511)1, 2, 9 Finegold D.N.... Ferrell R.E. (2001)
    5. Clustered arrangement of winged helix genes fkh-6 and MFH-1: possible implications for mesoderm development. (PubMed id 8674414)1, 3, 9 Kaestner K.H....Schutz G. (1996)
    6. Role of the FOXC2 -512C>T polymorphism in type 2 diabetes: possible association with the dysmetabolic syndrome. (PubMed id 15597109)1, 4, 9 Carlsson E....Ridderstrale M. (2005)
    7. Genetic variation in the human winged helix/forkhead transcription factor gene FOXC2 in Pima Indians. (PubMed id 12716768)1, 4, 9 Kovacs P....Baier L.J. (2003)
    8. The FOXC2 C-512T polymorphism is associated with obesity and dyslipidemia. (PubMed id 15601967)1, 4, 9 Carlsson E....Ridderstrale M. (2004)
    9. Analysis of lymphoedema-distichiasis families for FOXC2 mutations reveals small insertions and deletions throughout the gene. (PubMed id 11499682)1, 2, 9 Bell R....Jeffery S. (2001)
    10. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4, 9 Yerges L.M....Zmuda J.M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2303 HGNC: 3801 AceView: FOXC2 Ensembl:ENSG00000176692 euGenes: HUgn2303
    ECgene: FOXC2 H-InvDB: FOXC2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FOXC2 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/FOXC2
    NIEHS-SNPshttp://egp.gs.washington.edu/data/foxc2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FOXC2 gene:
    Search GeneIP for patents involving FOXC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for FOXC2 (FoxC2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for FOXC2   OriGene RNAi products in human, mouse, rat for FOXC2  
     OriGene qPCR primer pairs and template standards for FOXC2   OriGene Protein Over-expression Lysate for FOXC2  
     OriGene MassSpec something-or-other for FOXC2   OriGene clones in human, mouse for FOXC2  
     OriGene qSTAR qPCR primer pairs in human, mouse for FOXC2   OriGene Purified Protein for FOXC2  
     OriGene ORF clones in mouse, rat for FOXC2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FOXC2   OriGene Custom Protein Services for FOXC2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FOXC2
     QIAGEN SeqTarget long-range PCR primers for resequencing FOXC2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXC2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXC2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXC2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXC2
     GenScript Custom Purified and Recombinant Proteins Services for FOXC2 GenScript cDNA clones with any tag delivered in your preferred vector for FOXC2
     GenScript Custom Assay Services for FOXC2 GenScript Custom Superior Antibodies Services for FOXC2
     GenScript Custom overexpressing Cell Line Services for FOXC2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FOXC2 promoter
     Search Chromatin IP Primers for FOXC2
     RT2 qPCR Primer Assay in human, mouse, rat FOXC2
     GNC Network for FOXC2
     SABiosciences PCR Arrays including human, mouse, rat FOXC2
     Search Tocris compounds for FOXC2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FOXC2 antibodies
     FOXC2 proteins
     FOXC2 lysates
     Antibodies for FOXC2
     See all of Abcam's Antibodies, Kits and Proteins for FOXC2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for FOXC2
     Antibodies for FOXC2
     ELISAs for FOXC2
     CLIAs for FOXC2
     Search LifeMap BioReagents cell lines for FOXC2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXC2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for FOXC2
     Browse SwitchGear Promoter luciferase reporter plasmids for FOXC2
     ThermoFisher Antibody for FOXC2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXC2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for FOXC2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FOXC2
    Customized:
     lentivirus for stable overexpression of FOXC2
     lentivirus expression plasmids for stable overexpression of FOXC2
     adenovirus for overexpression of FOXC2
     LSBio Antibodies in human, mouse, rat for FOXC2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FOXC2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4