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Aliases for FOXC2 Gene

Aliases for FOXC2 Gene

  • Forkhead Box C2 2 3 5
  • Forkhead Box C2 (MFH-1, Mesenchyme Forkhead 1) 2 3
  • Forkhead-Related Protein FKHL14 3 4
  • Mesenchyme Fork Head Protein 1 3 4
  • Transcription Factor FKH-14 3 4
  • Mesenchyme Forkhead 1 2 3
  • FKHL14 3 4
  • MFH1 3 4
  • Forkhead, Drosophila, Homolog-Like 14 3
  • MFH-1,Mesenchyme Forkhead 1 3
  • MFH-1 Protein 4
  • MFH-1 3
  • LD 3

External Ids for FOXC2 Gene

Previous HGNC Symbols for FOXC2 Gene

  • FKHL14

Previous GeneCards Identifiers for FOXC2 Gene

  • GC16P077956
  • GC16P087633
  • GC16P086341
  • GC16P086382
  • GC16P085158
  • GC16P086600
  • GC16P072340

Summaries for FOXC2 Gene

Entrez Gene Summary for FOXC2 Gene

  • This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXC2 Gene

FOXC2 (Forkhead Box C2) is a Protein Coding gene. Diseases associated with FOXC2 include Lymphedema-Distichiasis Syndrome and Lymphedema. Among its related pathways are Glucose / Energy Metabolism and Heart Development. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is FOXE3.

UniProtKB/Swiss-Prot for FOXC2 Gene

  • Transcriptional activator. Might be involved in the formation of special mesenchymal tissues.

Gene Wiki entry for FOXC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXC2 Gene

Genomics for FOXC2 Gene

Regulatory Elements for FOXC2 Gene

Enhancers for FOXC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FOXC2 on UCSC Golden Path with GeneCards custom track

Promoters for FOXC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FOXC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FOXC2 Gene

86,567,251 bp from pter
86,569,728 bp from pter
2,478 bases
Plus strand

Genomic View for FOXC2 Gene

Genes around FOXC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXC2 Gene

Proteins for FOXC2 Gene

  • Protein details for FOXC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Forkhead box protein C2
    Protein Accession:
    Secondary Accessions:
    • C6KMR9
    • Q14DA6

    Protein attributes for FOXC2 Gene

    501 amino acids
    Molecular mass:
    53719 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FOXC2 Gene

neXtProt entry for FOXC2 Gene

Proteomics data for FOXC2 Gene at MOPED

Post-translational modifications for FOXC2 Gene

  • Phosphorylation regulates FOXC2 transcriptional activity by promoting its recruitment to chromatin.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FOXC2 (FOXC2)
  • Abcam antibodies for FOXC2

No data available for DME Specific Peptides for FOXC2 Gene

Domains & Families for FOXC2 Gene

Gene Families for FOXC2 Gene

Protein Domains for FOXC2 Gene

Suggested Antigen Peptide Sequences for FOXC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 fork-head DNA-binding domain.
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXC2: view

Function for FOXC2 Gene

Molecular function for FOXC2 Gene

GENATLAS Biochemistry:
transcription factor-like 14,with a Drosophila homeo forkhead DNA binding domain homolog,homolog to mouse mesenchyme forkhead 1 (MFH-1)
UniProtKB/Swiss-Prot Function:
Transcriptional activator. Might be involved in the formation of special mesenchymal tissues.

Gene Ontology (GO) - Molecular Function for FOXC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IEA,IDA 16081467
genes like me logo Genes that share ontologies with FOXC2: view
genes like me logo Genes that share phenotypes with FOXC2: view

Human Phenotype Ontology for FOXC2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FOXC2 Gene

MGI Knock Outs for FOXC2:

Animal Model Products

miRNA for FOXC2 Gene

miRTarBase miRNAs that target FOXC2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FOXC2 Gene

Localization for FOXC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXC2 Gene

Subcellular locations from

Jensen Localization Image for FOXC2 Gene COMPARTMENTS Subcellular localization image for FOXC2 gene
Compartment Confidence
nucleus 5
cytoskeleton 1
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for FOXC2 Gene

Pathways & Interactions for FOXC2 Gene

genes like me logo Genes that share pathways with FOXC2: view

Pathways by source for FOXC2 Gene

1 Cell Signaling Technology pathway for FOXC2 Gene
2 BioSystems pathways for FOXC2 Gene

Gene Ontology (GO) - Biological Process for FOXC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0001501 skeletal system development IEA --
GO:0001503 ossification IEA --
GO:0001568 blood vessel development IEA --
GO:0001656 metanephros development IEA --
genes like me logo Genes that share ontologies with FOXC2: view

No data available for SIGNOR curated interactions for FOXC2 Gene

Drugs & Compounds for FOXC2 Gene

(2) Additional Compounds for FOXC2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FOXC2: view

Transcripts for FOXC2 Gene

mRNA/cDNA for FOXC2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXC2 Gene

Forkhead box C2 (MFH-1, mesenchyme forkhead 1):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXC2 Gene

No ASD Table

Relevant External Links for FOXC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FOXC2 Gene

mRNA expression in normal human tissues for FOXC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXC2 Gene

This gene is overexpressed in Artery - Aorta (x11.5), Artery - Tibial (x10.8), and Artery - Coronary (x7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FOXC2 Gene

SOURCE GeneReport for Unigene cluster for FOXC2 Gene Hs.436448

genes like me logo Genes that share expression patterns with FOXC2: view

Primer Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FOXC2 Gene

Orthologs for FOXC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FOXC2 35
  • 94.01 (n)
  • 96.21 (a)
FOXC2 36
  • 96 (a)
(Canis familiaris)
Mammalia FOXC2 35
  • 93.41 (n)
  • 95.41 (a)
FOXC2 36
  • 96 (a)
(Mus musculus)
Mammalia Foxc2 35
  • 86.84 (n)
  • 88.26 (a)
Foxc2 16
Foxc2 36
  • 91 (a)
(Pan troglodytes)
Mammalia FOXC2 35
  • 99.42 (n)
  • 99.26 (a)
FOXC2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Foxc2 35
  • 86.77 (n)
  • 87.85 (a)
(Monodelphis domestica)
Mammalia FOXC2 36
  • 82 (a)
(Gallus gallus)
Aves FOXC2 35
  • 77.52 (n)
  • 76.83 (a)
FOXC2 36
  • 71 (a)
(Anolis carolinensis)
Reptilia FOXC2 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia foxc2 35
  • 73.29 (n)
  • 72.05 (a)
Str.2696 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.508 35
(Danio rerio)
Actinopterygii foxl2 36
  • 32 (a)
fruit fly
(Drosophila melanogaster)
Insecta croc 37
  • 53 (a)
fd64A 37
  • 65 (a)
fd96Cb 37
  • 62 (a)
croc 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
Species with no ortholog for FOXC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXC2 Gene

Gene Tree for FOXC2 (if available)
Gene Tree for FOXC2 (if available)

Paralogs for FOXC2 Gene

genes like me logo Genes that share paralogs with FOXC2: view

Variants for FOXC2 Gene

Sequence variations from dbSNP and Humsavar for FOXC2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_018418 Lymphedema-distichiasis (LYD)
VAR_060950 -

Structural Variations from Database of Genomic Variants (DGV) for FOXC2 Gene

Variant ID Type Subtype PubMed ID
esv4262 CNV Complex 18987735
nsv525024 CNV Loss 19592680
dgv498n67 CNV Gain 20364138
nsv907132 CNV Loss 21882294
dgv2947n71 CNV Loss 21882294
nsv907137 CNV Loss 21882294
nsv907138 CNV Loss 21882294

Variation tolerance for FOXC2 Gene

Residual Variation Intolerance Score: 45.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXC2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXC2 Gene

Disorders for FOXC2 Gene

MalaCards: The human disease database

(18) MalaCards diseases for FOXC2 Gene - From: OMIM, ClinVar, GeneTests, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lymphedema-distichiasis syndrome
  • lymphedema-distichiasis syndrome with renal disease and diabetes mellitus
  • lymphatic edema
hereditary lymphedema
  • milroy's disease
  • blepharoptosis
arachnoid cysts
  • arachnoid cysts, intracranial
- elite association - COSMIC cancer census association via MalaCards
Search FOXC2 in MalaCards View complete list of genes associated with diseases


  • Lymphedema-distichiasis (LYD) [MIM:153400]: A disorder characterized by primary limb lymphedema associated with distichiasis (double rows of eyelashes, with extra eyelashes growing from the Meibomian gland orifices). Swelling of the extremities, due to altered lymphatic flow, usually appears in late childhood or puberty. Most affected individuals have ocular findings including corneal irritation, recurrent conjunctivitis, and photophobia. Drooping of the upper eyelid (ptosis) is a variable feature of the lymphedema-distichiasis syndrome, occurring in about 30% of patients. {ECO:0000269 PubMed:11078474, ECO:0000269 PubMed:11371511, ECO:0000269 PubMed:11499682}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for FOXC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FOXC2: view

No data available for Genatlas for FOXC2 Gene

Publications for FOXC2 Gene

  1. Isolation of the mouse (MFH-1) and human (FKHL 14) mesenchyme fork head-1 genes reveals conservation of their gene and protein structures. (PMID: 9169153) Miura N. … Sugiyama T. (Genomics 1997) 2 3 4 23 67
  2. Clustered arrangement of winged helix genes fkh-6 and MFH-1: possible implications for mesoderm development. (PMID: 8674414) Kaestner K.H. … SchA1tz G. (Development 1996) 2 3 23
  3. A case of lymphedema-distichiasis syndrome carrying a new de novo frameshift FOXC2 mutation. (PMID: 20450314) Fabretto A. … Gasparini P. (Ophthalmic Genet. 2010) 3 23
  4. p120-catenin is transcriptionally downregulated by FOXC2 in non-small cell lung cancer cells. (PMID: 20460685) Mortazavi F. … Rettig M. (Mol. Cancer Res. 2010) 3 23
  5. Prox-1 and FOXC2 gene expression in adipose tissue: A potential contributory role of the lymphatic system to familial combined hyperlipidaemia. (PMID: 19339011) Horra A. … Ribalta J. (Atherosclerosis 2009) 3 23

Products for FOXC2 Gene

Sources for FOXC2 Gene